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Benjamin Spiller, Ph.D. - Publications

Affiliations: 
1995-1999 University of California, Berkeley, Berkeley, CA, United States 
 1999- Vanderbilt University, Nashville, TN 
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kordus SL, Kroh HK, Rodríguez RC, Shrem RA, Peritore-Galve FC, Shupe JA, Wadzinski BE, Lacy DB, Spiller BW. Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo. Plos Pathogens. 19: e1011496. PMID 37871122 DOI: 10.1371/journal.ppat.1011496  0.566
2020 Farrow MA, Chumbler NM, Bloch SC, King M, Moton-Melancon K, Shupe J, Washington MK, Spiller BW, Lacy DB. A small molecule inhibitor screen reveals calcium channel signaling as a mechanistic mediator of Clostridium difficile TcdB-induced necrosis. Acs Chemical Biology. PMID 31909964 DOI: 10.1021/Acschembio.9B00906  0.461
2017 Kroh HK, Chandrasekaran R, Zhang Z, Rosenthal K, Woods R, Jin X, Nyborg AC, Rainey GJ, Warrener P, Melnyk RA, Spiller BW, Lacy DB. A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells. The Journal of Biological Chemistry. PMID 29180448 DOI: 10.1074/jbc.M117.813428  0.567
2017 Kroh HK, Chandrasekaran R, Rosenthal K, Woods R, Jin X, Ohi MD, Nyborg AC, Rainey GJ, Warrener P, Spiller BW, Lacy DB. Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface. The Journal of Biological Chemistry. PMID 28705932 DOI: 10.1074/Jbc.M117.781112  0.617
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1: 15002. PMID 27571750 DOI: 10.1038/Nmicrobiol.2015.2  0.592
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1. PMID 27512603 DOI: 10.1038/nmicrobiol.2015.2  0.592
2016 González-Rivera C, Campbell AM, Rutherford SA, Pyburn TM, Foegeding NJ, Barke TL, Spiller BW, McClain MS, Ohi MD, Lacy DB, Cover TL. A non-oligomerizing mutant form of Helicobacter pylori VacA allows structural analysis of the p33 domain. Infection and Immunity. PMID 27382020 DOI: 10.1128/Iai.00254-16  0.57
2014 Archuleta TL, Spiller BW. A gatekeeper chaperone complex directs translocator secretion during type three secretion. Plos Pathogens. 10: e1004498. PMID 25375170 DOI: 10.1371/journal.ppat.1004498  0.304
2012 McHaourab HS, Lin YL, Spiller BW. Crystal structure of an activated variant of small heat shock protein Hsp16.5. Biochemistry. 51: 5105-12. PMID 22670769 DOI: 10.1021/Bi300525X  0.319
2012 Pruitt RN, Chumbler NM, Rutherford SA, Farrow MA, Friedman DB, Spiller B, Lacy DB. Structural determinants of Clostridium difficile toxin A glucosyltransferase activity. The Journal of Biological Chemistry. 287: 8013-20. PMID 22267739 DOI: 10.1074/Jbc.M111.298414  0.6
2011 Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW. The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. The Journal of Biological Chemistry. 286: 33992-8. PMID 21841198 DOI: 10.1074/Jbc.M111.258426  0.311
2011 Coffa S, Breitman M, Spiller BW, Gurevich VV. A single mutation in arrestin-2 prevents ERK1/2 activation by reducing c-Raf1 binding. Biochemistry. 50: 6951-8. PMID 21732673 DOI: 10.1021/Bi200745K  0.564
2011 LeNoue-Newton M, Watkins GR, Zou P, Germane KL, McCorvey LR, Wadzinski BE, Spiller BW. The E3 ubiquitin ligase- and protein phosphatase 2A (PP2A)-binding domains of the Alpha4 protein are both required for Alpha4 to inhibit PP2A degradation. The Journal of Biological Chemistry. 286: 17665-71. PMID 21454489 DOI: 10.1074/Jbc.M111.222414  0.686
2011 Germane KL, Spiller BW. Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase. Biochemistry. 50: 917-9. PMID 21235237 DOI: 10.1021/Bi1020138  0.71
2011 Zhan X, Gimenez LE, Gurevich VV, Spiller BW. Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes. Journal of Molecular Biology. 406: 467-78. PMID 21215759 DOI: 10.1016/J.Jmb.2010.12.034  0.342
2010 Schmitt J, Karalewitz A, Benefield DA, Mushrush DJ, Pruitt RN, Spiller BW, Barbieri JT, Lacy DB. Structural analysis of botulinum neurotoxin type G receptor binding . Biochemistry. 49: 5200-5. PMID 20507178 DOI: 10.1021/Bi100412V  0.525
2009 Pruitt RN, Chagot B, Cover M, Chazin WJ, Spiller B, Lacy DB. Structure-function analysis of inositol hexakisphosphate-induced autoprocessing in Clostridium difficile toxin A. The Journal of Biological Chemistry. 284: 21934-40. PMID 19553670 DOI: 10.1074/Jbc.M109.018929  0.611
2008 Germane KL, Ohi R, Goldberg MB, Spiller BW. Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules. Biochemistry. 47: 10241-3. PMID 18763811 DOI: 10.1021/Bi801533K  0.686
2007 Gangwer KA, Mushrush DJ, Stauff DL, Spiller B, McClain MS, Cover TL, Lacy DB. Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 16293-8. PMID 17911250 DOI: 10.1073/Pnas.0707447104  0.573
1999 Spiller B, Gershenson A, Arnold FH, Stevens RC. A structural view of evolutionary divergence. Proceedings of the National Academy of Sciences of the United States of America. 96: 12305-10. PMID 10535917 DOI: 10.1073/Pnas.96.22.12305  0.473
1998 Romesberg FE, Santarsiero BD, Spiller B, Yin J, Barnes D, Schultz PG, Stevens RC. Structural and kinetic evidence for strain in biological catalysis. Biochemistry. 37: 14404-9. PMID 9772166 DOI: 10.1021/Bi981578C  0.559
1998 Romesberg FE, Spiller B, Schultz PG, Stevens RC. Immunological origins of binding and catalysis in a Diels-Alderase antibody. Science (New York, N.Y.). 279: 1929-33. PMID 9506942 DOI: 10.1126/Science.279.5358.1929  0.475
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