Mauro Mileni, Ph.D. - Publications

Affiliations: 
2006-2011 Scripps Research Institute 
 2011-2013 Receptos 
 2014- Abilita Bio 

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, et al. Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 161: 1633-43. PMID 26091040 DOI: 10.1016/j.cell.2015.06.002  0.52
2014 Skjevik AA, Mileni M, Baumann A, Halskau O, Teigen K, Stevens RC, Martinez A. The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. Journal of Molecular Biology. 426: 150-68. PMID 24055376 DOI: 10.1016/j.jmb.2013.09.012  0.52
2012 Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, et al. Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32. PMID 22437504 DOI: 10.1038/nature10939  0.52
2011 Miller MT, Mileni M, Comoletti D, Stevens RC, Harel M, Taylor P. The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure (London, England : 1993). 19: 767-78. PMID 21620717 DOI: 10.1016/j.str.2011.03.011  0.52
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. Journal of Medicinal Chemistry. 54: 2805-22. PMID 21428410 DOI: 10.1021/jm101597x  0.52
2011 Baksh MM, Kussrow AK, Mileni M, Finn MG, Bornhop DJ. Label-free quantification of membrane-ligand interactions using backscattering interferometry. Nature Biotechnology. 29: 357-60. PMID 21399645 DOI: 10.1038/nbt.1790  0.52
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/ja110877y  0.52
2011 Lodola A, Capoferri L, Rivara S, Chudyk E, Sirirak J, Dyguda-Kazimierowicz E, Andrzej Sokalski W, Mileni M, Tarzia G, Piomelli D, Mor M, Mulholland AJ. Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling. Chemical Communications (Cambridge, England). 47: 2517-9. PMID 21240393 DOI: 10.1039/c0cc04937a  0.52
2010 Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. Journal of Molecular Biology. 400: 743-54. PMID 20493882 DOI: 10.1016/j.jmb.2010.05.034  0.52
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/jm9012196  0.52
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/ja902694n  0.52
2009 Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & Biology. 16: 411-20. PMID 19389627 DOI: 10.1016/j.chembiol.2009.02.013  0.52
2008 Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proceedings of the National Academy of Sciences of the United States of America. 105: 12820-4. PMID 18753625 DOI: 10.1073/pnas.0806121105  0.52
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/j.bmcl.2008.06.086  0.52
2008 Alexandrov AI, Mileni M, Chien EY, Hanson MA, Stevens RC. Microscale fluorescent thermal stability assay for membrane proteins. Structure (London, England : 1993). 16: 351-9. PMID 18334210 DOI: 10.1016/j.str.2008.02.004  0.52
2006 Lancaster CR, Haas AH, Madej MG, Mileni M. Recent progress on obtaining theoretical and experimental support for the "E-pathway hypothesis" of coupled transmembrane electron and proton transfer in dihaem-containing quinol:fumarate reductase. Biochimica Et Biophysica Acta. 1757: 988-95. PMID 16790236 DOI: 10.1016/j.bbabio.2006.05.012  0.52
2006 Mileni M, MacMillan F, Tziatzios C, Zwicker K, Haas AH, Mäntele W, Simon J, Lancaster CR. Heterologous production in Wolinella succinogenes and characterization of the quinol:fumarate reductase enzymes from Helicobacter pylori and Campylobacter jejuni. The Biochemical Journal. 395: 191-201. PMID 16367742 DOI: 10.1042/BJ20051675  0.52
2005 Mileni M, Haas AH, Mäntele W, Simon J, Lancaster CR. Probing heme propionate involvement in transmembrane proton transfer coupled to electron transfer in dihemic quinol:fumarate reductase by 13C-labeling and FTIR difference spectroscopy. Biochemistry. 44: 16718-28. PMID 16342962 DOI: 10.1021/bi051034s  0.52
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