Veli-Pekka Jaakola, Ph.D. - Publications

Affiliations: 
2006-2009 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2009- University of Oulu, Oulu, Finland 

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Harborne SPD, Strauss J, Boakes JC, Wright DL, Henderson JG, Boivineau J, Jaakola VP, Goldman A. IMPROvER: the Integral Membrane Protein Stability Selector. Scientific Reports. 10: 15165. PMID 32938971 DOI: 10.1038/s41598-020-71744-x  1
2020 Boivineau J, Haffke M, Jaakola VP. Membrane Protein Expression in Insect Cells Using the Baculovirus Expression Vector System. Methods in Molecular Biology (Clifton, N.J.). 2127: 63-80. PMID 32112315 DOI: 10.1007/978-1-0716-0373-4_5  0.48
2019 Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 574: 581-585. PMID 31645725 DOI: 10.1038/s41586-019-1663-8  0.48
2019 Rehan S, Shahid S, Salminen TA, Jaakola VP, Paavilainen VO. Current Progress on Equilibrative Nucleoside Transporter Function and Inhibitor Design. Slas Discovery : Advancing Life Sciences R & D. 2472555219870123. PMID 31503511 DOI: 10.1177/2472555219870123  0.48
2017 Rehan S, Paavilainen VO, Jaakola VP. Functional Reconstitution of Human Equilibrative Nucleoside Transporter-1 into Styrene Maleic Acid Co-polymer Lipid Particles. Biochimica Et Biophysica Acta. PMID 28254415 DOI: 10.1016/j.bbamem.2017.02.017  0.48
2017 Piirainen H, Taura J, Kursula P, Ciruela F, Jaakola VP. Calcium modulates calmodulin/α-actinin 1 interaction with and agonist-dependent internalization of the adenosine A2A receptor. Biochimica Et Biophysica Acta. PMID 28130124 DOI: 10.1016/j.bbamcr.2017.01.013  0.68
2016 Ashok Y, Jaakola VP. Nanodisc-Tm: Rapid functional assessment of nanodisc reconstituted membrane proteins by CPM assay. Methodsx. 3: 212-8. PMID 27054097 DOI: 10.1016/j.mex.2016.03.009  1
2015 Rehan S, Ashok Y, Nanekar R, Jaakola VP. Thermodynamics and kinetics of inhibitor binding to human equilibrative nucleoside transporter subtype-1. Biochemical Pharmacology. PMID 26428002 DOI: 10.1016/j.bcp.2015.09.019  1
2015 Ashok Y, Nanekar R, Jaakola VP. Defining thermostability of membrane proteins by western blotting. Protein Engineering, Design & Selection : Peds. 28: 539-42. PMID 26384510 DOI: 10.1093/protein/gzv049  1
2015 Rehan S, Jaakola VP. Expression, purification and functional characterization of human equilibrative nucleoside transporter subtype-1 (hENT1) protein from Sf9 insect cells. Protein Expression and Purification. 114: 99-107. PMID 26162242 DOI: 10.1016/j.pep.2015.07.003  1
2015 Tossavainen H, Hellman M, Piirainen H, Jaakola VP, Permi P. H(N), N, C(α), C (β) and C' assignments of the intrinsically disordered C-terminus of human adenosine A2A receptor. Biomolecular Nmr Assignments. PMID 25952762 DOI: 10.1007/s12104-015-9618-y  1
2015 Saarenpää T, Jaakola VP, Goldman A. Baculovirus-mediated expression of GPCRs in insect cells. Methods in Enzymology. 556: 185-218. PMID 25857783 DOI: 10.1016/bs.mie.2014.12.033  1
2015 Piirainen H, Hellman M, Tossavainen H, Permi P, Kursula P, Jaakola VP. Human adenosine A2A receptor binds calmodulin with high affinity in a calcium-dependent manner. Biophysical Journal. 108: 903-17. PMID 25692595 DOI: 10.1016/j.bpj.2014.12.036  1
2014 Hellman M, Piirainen H, Jaakola VP, Permi P. Bridge over troubled proline: assignment of intrinsically disordered proteins using (HCA)CON(CAN)H and (HCA)N(CA)CO(N)H experiments concomitantly with HNCO and i(HCA)CO(CA)NH. Journal of Biomolecular Nmr. 58: 49-60. PMID 24346685 DOI: 10.1007/s10858-013-9804-0  1
2013 Ashok Y, Nanekar RT, Jaakola VP. Crystallogenesis of adenosine A(2A) receptor-T4 lysozyme fusion protein: a practical route for the structure. Methods in Enzymology. 520: 175-98. PMID 23332700 DOI: 10.1016/B978-0-12-391861-1.00008-3  1
2011 Lane JR, Jaakola VP, Ijzerman AP. The structure of the adenosine receptors: implications for drug discovery. Advances in Pharmacology (San Diego, Calif.). 61: 1-40. PMID 21586354 DOI: 10.1016/B978-0-12-385526-8.00001-1  1
2011 Piirainen H, Ashok Y, Nanekar RT, Jaakola VP. Structural features of adenosine receptors: from crystal to function. Biochimica Et Biophysica Acta. 1808: 1233-44. PMID 20595055 DOI: 10.1016/j.bbamem.2010.05.021  1
2010 Jaakola VP, Ijzerman AP. The crystallographic structure of the human adenosine A2A receptor in a high-affinity antagonist-bound state: implications for GPCR drug screening and design. Current Opinion in Structural Biology. 20: 401-14. PMID 20538452 DOI: 10.1016/j.sbi.2010.05.002  1
2010 Jaakola VP, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC. Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues. The Journal of Biological Chemistry. 285: 13032-44. PMID 20147292 DOI: 10.1074/jbc.M109.096974  1
2010 Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists. Journal of Medicinal Chemistry. 53: 1799-809. PMID 20095623 DOI: 10.1021/jm901647p  1
2010 Jaakola VP, Stevens RC. G protein-coupled receptor structures Handbook of Cell Signaling, 2/E. 1: 129-138. DOI: 10.1016/B978-0-12-374145-5.00020-6  1
2008 Jaakola VP, Griffith MT, Hanson MA, Cherezov V, Chien EY, Lane JR, Ijzerman AP, Stevens RC. The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (New York, N.Y.). 322: 1211-7. PMID 18832607 DOI: 10.1126/science.1164772  1
2008 Hanson MA, Cherezov V, Griffith MT, Roth CB, Jaakola VP, Chien EY, Velasquez J, Kuhn P, Stevens RC. A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (London, England : 1993). 16: 897-905. PMID 18547522 DOI: 10.1016/j.str.2008.05.001  1
2007 Hanson MA, Brooun A, Baker KA, Jaakola VP, Roth C, Chien EY, Alexandrov A, Velasquez J, Davis L, Griffith M, Moy K, Ganser-Pornillos BK, Hua Y, Kuhn P, Ellis S, et al. Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expression and Purification. 56: 85-92. PMID 17723307 DOI: 10.1016/j.pep.2007.06.003  1
2007 Zhang Q, Ma X, Ward A, Hong WX, Jaakola VP, Stevens RC, Finn MG, Chang G. Designing facial amphiphiles for the stabilization of integral membrane proteins. Angewandte Chemie (International Ed. in English). 46: 7023-5. PMID 17691085 DOI: 10.1002/anie.200701556  1
2006 Oksanen E, Jaakola VP, Tolonen T, Valkonen K, Akerström B, Kalkkinen N, Virtanen V, Goldman A. Reindeer beta-lactoglobulin crystal structure with pseudo-body-centred noncrystallographic symmetry. Acta Crystallographica. Section D, Biological Crystallography. 62: 1369-74. PMID 17057340 DOI: 10.1107/S0907444906031519  1
2006 Jokiranta TS, Jaakola VP, Lehtinen MJ, Pärepalo M, Meri S, Goldman A. Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome. The Embo Journal. 25: 1784-94. PMID 16601698 DOI: 10.1038/sj.emboj.7601052  1
2005 Jaakola VP, Vainio M, Sen S, Rehn M, Heimo H, Scheinin M, Goldman A. Intracellularly truncated human alpha2B-adrenoceptors: stable and functional GPCRs for structural studies. Journal of Receptor and Signal Transduction Research. 25: 99-124. PMID 16149769 DOI: 10.1081/RRS-200068745  1
2005 Jaakola VP, Rehn M, Moeller M, Alexiev U, Goldman A, Turner GJ. G-protein-coupled receptor domain overexpression in Halobacterium salinarum: long-range transmembrane interactions in heptahelical membrane proteins. Proteins. 60: 412-23. PMID 15971205 DOI: 10.1002/prot.20498  1
2005 Sen S, Jaakola VP, Pirilä P, Finel M, Goldman A. Functional studies with membrane-bound and detergent-solubilized alpha2-adrenergic receptors expressed in Sf9 cells. Biochimica Et Biophysica Acta. 1712: 62-70. PMID 15893292 DOI: 10.1016/j.bbamem.2005.03.014  1
2005 Jaakola VP, Prilusky J, Sussman JL, Goldman A. G protein-coupled receptors show unusual patterns of intrinsic unfolding. Protein Engineering, Design & Selection : Peds. 18: 103-10. PMID 15790574 DOI: 10.1093/protein/gzi004  1
2003 Sen S, Jaakola VP, Heimo H, Engström M, Larjomaa P, Scheinin M, Lundstrom K, Goldman A. Functional expression and direct visualization of the human alpha 2B -adrenergic receptor and alpha 2B -AR-green fluorescent fusion protein in mammalian cell using Semliki Forest virus vectors. Protein Expression and Purification. 32: 265-75. PMID 14965773 DOI: 10.1016/j.pep.2003.08.006  1
2003 Bartus CL, Jaakola VP, Reusch R, Valentine HH, Heikinheimo P, Levay A, Potter LT, Heimo H, Goldman A, Turner GJ. Downstream coding region determinants of bacterio-opsin, muscarinic acetylcholine receptor and adrenergic receptor expression in Halobacterium salinarum. Biochimica Et Biophysica Acta. 1610: 109-23. PMID 12586385 DOI: 10.1016/S0005-2736(02)00710-1  1
2002 Sen S, Jaakola VP, Heimo H, Kivelä P, Scheinin M, Lundstrom K, Goldman A. Development of a scintiplate assay for recombinant human alpha(2B)-adrenergic receptor. Analytical Biochemistry. 307: 280-6. PMID 12202245 DOI: 10.1016/S0003-2697(02)00041-6  1
2000 Kapat A, Jaakola VP, Heimo H, Liitti S, Heikinheimo P, Glumoff T, Goldman A. Production and purification of recombinant human alpha 2C2 adrenergic receptor using Saccharomyces cerevisiae. Bioseparation. 9: 167-72. PMID 11105246 DOI: 10.1023/A:1008150412294  1
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