| Year |
Citation |
Score |
| 2023 |
Milly TA, Renshaw CP, Tal-Gan Y. Developing multispecies quorum-sensing modulators based on the Streptococcus mitis competence-stimulating peptide. The Journal of Biological Chemistry. 299: 105448. PMID 37951305 DOI: 10.1016/j.jbc.2023.105448 |
0.436 |
|
| 2023 |
Proutière A, du Merle L, Garcia-Lopez M, Léger C, Voegele A, Chenal A, Harrington A, Tal-Gan Y, Cokelaer T, Trieu-Cuot P, Dramsi S. Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity. Microbiology Spectrum. e0508522. PMID 36951576 DOI: 10.1128/spectrum.05085-22 |
0.504 |
|
| 2022 |
Milly TA, Tal-Gan Y. Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections. Peptide Science (Hoboken, N.J.). 115. PMID 37397504 DOI: 10.1002/pep2.24298 |
0.46 |
|
| 2022 |
McBrayer DN, Ghosh U, Lella M, Cameron CD, Tal-Gan Y. Peptoid-Peptide Hybrid Analogs of the Enterococcus faecalis Fsr Auto-Inducing Peptide (AIP) Reveal Crucial Structure-Activity Relationships. Chembiochem : a European Journal of Chemical Biology. PMID 36376247 DOI: 10.1002/cbic.202200527 |
0.529 |
|
| 2022 |
Brennan AA, Mehrani M, Tal-Gan Y. Modulating streptococcal phenotypes using signal peptide analogues. Open Biology. 12: 220143. PMID 35920042 DOI: 10.1098/rsob.220143 |
0.334 |
|
| 2022 |
Oh MW, Lella M, Kuo SH, Tal-Gan Y, Lau GW. Pharmacological Evaluation of Synthetic Dominant-Negative Peptides Derived from the Competence-Stimulating Peptide of . Acs Pharmacology & Translational Science. 5: 299-305. PMID 35592433 DOI: 10.1021/acsptsci.2c00037 |
0.538 |
|
| 2022 |
Lella M, Oh MW, Kuo SH, Lau GW, Tal-Gan Y. Attenuating the Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs. Journal of Medicinal Chemistry. 65: 6826-6839. PMID 35452241 DOI: 10.1021/acs.jmedchem.2c00148 |
0.471 |
|
| 2022 |
Milly TA, Buttner AR, Rieth N, Hutnick E, Engler ER, Campanella AR, Lella M, Bertucci MA, Tal-Gan Y. Optimizing CSP1 analogs for modulating quorum sensing in with bulky, hydrophobic nonproteogenic amino acid substitutions. Rsc Chemical Biology. 3: 301-311. PMID 35359494 DOI: 10.1039/d1cb00224d |
0.444 |
|
| 2021 |
Mull RW, Tal-Gan Y. Elucidating the Role and Structure-Activity Relationships of the Competence-Stimulating Peptide. Acs Chemical Biology. 16: 2834-2844. PMID 34860484 DOI: 10.1021/acschembio.1c00746 |
0.427 |
|
| 2021 |
Lella M, Tal-Gan Y. Strategies to Attenuate the Competence Regulon in . Peptide Science (Hoboken, N.J.). 113. PMID 34337308 DOI: 10.1002/pep2.24222 |
0.321 |
|
| 2021 |
Milly TA, Engler ER, Chichura KS, Buttner AR, Koirala B, Tal-Gan Y, Bertucci MA. Harnessing multiple, non-proteogenic substitutions to optimize CSP:ComD hydrophobic interactions in group1 Streptococcus pneumoniae. Chembiochem : a European Journal of Chemical Biology. PMID 33644965 DOI: 10.1002/cbic.202000876 |
0.386 |
|
| 2021 |
Harrington A, Proutière A, Mull RW, du Merle L, Dramsi S, Tal-Gan Y. Secretion, Maturation, and Activity of a Quorum Sensing Peptide (GSP) Inducing Bacteriocin Transcription in Streptococcus gallolyticus. Mbio. 12. PMID 33402540 DOI: 10.1128/mBio.03189-20 |
0.483 |
|
| 2020 |
Mull RW, Brennan AA, Russ BR, Tal-Gan Y. Attenuating the Selection of Vancomycin Resistance Among through the Development of Peptide-Based Vancomycin Antagonists. Acs Infectious Diseases. PMID 32946213 DOI: 10.1021/Acsinfecdis.0C00319 |
0.473 |
|
| 2020 |
Bikash CR, Tal-Gan Y. Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in Reveal Inhibitors of the Competence Regulon. Acs Chemical Biology. 15: 2833-2841. PMID 32946208 DOI: 10.1021/Acschembio.0C00650 |
0.56 |
|
| 2020 |
McBrayer DN, Cameron CD, Tal-Gan Y. Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria. Organic & Biomolecular Chemistry. PMID 32914160 DOI: 10.1039/D0Ob01421D |
0.578 |
|
| 2020 |
Milly TA, Tal-Gan Y. Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveal Potential Crosstalk Between and and a New Scaffold for the Development of Quorum Sensing Modulators. Rsc Chemical Biology. 1: 60-67. PMID 32905481 DOI: 10.1039/D0CB00012D |
0.406 |
|
| 2020 |
Yang Y, Lin J, Harrington A, Cornilescu G, Lau GW, Tal-Gan Y. Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31915298 DOI: 10.1073/Pnas.1915812117 |
0.547 |
|
| 2019 |
Harrington A, Tal-Gan Y. The importance of amide protons in peptide drug development. Future Medicinal Chemistry. PMID 31702388 DOI: 10.4155/Fmc-2019-0238 |
0.496 |
|
| 2019 |
Koirala B, Tal-Gan Y. Development of Streptococcus pneumoniae Pan Group Quorum Sensing Modulators. Chembiochem : a European Journal of Chemical Biology. PMID 31291510 DOI: 10.1002/cbic.201900365 |
0.415 |
|
| 2019 |
Koirala B, Phillips NR, Tal-Gan Y. Unveiling the Importance of Amide Protons in CSP:ComD Interactions in . Acs Medicinal Chemistry Letters. 10: 880-886. PMID 31223442 DOI: 10.1021/Acsmedchemlett.9B00038 |
0.525 |
|
| 2019 |
Yang Y, Tal-Gan Y. Exploring the competence stimulating peptide (CSP) N-terminal requirements for effective ComD receptor activation in group1 Streptococcus pneumoniae. Bioorganic Chemistry. 89: 102987. PMID 31132605 DOI: 10.1016/J.Bioorg.2019.102987 |
0.52 |
|
| 2019 |
McBrayer DN, Tal-Gan Y. Deciphering bacterial signalling. Nature Chemistry. 11: 398-399. PMID 31011174 DOI: 10.1038/S41557-019-0265-2 |
0.407 |
|
| 2019 |
McBrayer DN, Gantman BK, Tal-Gan Y. N-methylation of amino acids in Gelatinase Biosynthesis-Activating Pheromone (GBAP) Identifies Key Site for Stability Enhancement with Retention of the Enterococcus faecalis Fsr Quorum Sensing Circuit Response. Acs Infectious Diseases. PMID 30973007 DOI: 10.1021/Acsinfecdis.9B00097 |
0.503 |
|
| 2019 |
Bikash CR, Tal-Gan Y. Identification of highly potent competence stimulating peptide-based quorum sensing activators in Streptococcus mutans through the utilization of N-methyl and reverse alanine scanning. Bioorganic & Medicinal Chemistry Letters. PMID 30711392 DOI: 10.1016/J.Bmcl.2019.01.029 |
0.56 |
|
| 2018 |
Koirala B, Lin J, Lau GW, Tal-Gan Y. Development of a Dominant Negative Competence Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia. Chembiochem : a European Journal of Chemical Biology. PMID 30211457 DOI: 10.1002/Cbic.201800505 |
0.542 |
|
| 2018 |
McBrayer DN, Cameron CD, Gantman BK, Tal-Gan Y. Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit. Acs Chemical Biology. PMID 30141904 DOI: 10.1021/Acschembio.8B00610 |
0.607 |
|
| 2018 |
Yang Y, Cornilescu G, Tal-Gan Y. Structural Characterization of Competence Stimulating Peptides (CSPs) Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry. PMID 30125091 DOI: 10.1021/Acs.Biochem.8B00653 |
0.59 |
|
| 2018 |
Koirala B, Hillman RA, Tiwold EK, Bertucci MA, Tal-Gan Y. Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in . Beilstein Journal of Organic Chemistry. 14: 1769-1777. PMID 30112082 DOI: 10.3762/Bjoc.14.151 |
0.559 |
|
| 2018 |
Bikash CR, Hamry SR, Tal-Gan Y. Structure-Activity Relationships (SARs) of the Competence Stimulating Peptide (CSP) in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor Activation. Acs Infectious Diseases. PMID 29990430 DOI: 10.1021/Acsinfecdis.8B00115 |
0.544 |
|
| 2018 |
Rubin SJS, Tal-Gan Y, Gilon C, Qvit N. Conversion of Protein Active Regions into Peptidomimetic Therapeutic Leads using Backbone Cyclization and Cycloscan - How to Do It Yourself. Current Topics in Medicinal Chemistry. PMID 29773063 DOI: 10.2174/1568026618666180518094322 |
0.699 |
|
| 2018 |
Mull RW, Harrington A, Sanchez LA, Tal-Gan Y. Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms. Current Topics in Medicinal Chemistry. PMID 29773060 DOI: 10.2174/1568026618666180518090705 |
0.556 |
|
| 2018 |
Harrington A, Tal-Gan Y. Identification ofsubsp.(biotype I) competence stimulating peptide pheromone. Journal of Bacteriology. PMID 29440256 DOI: 10.1128/Jb.00709-17 |
0.59 |
|
| 2017 |
McBrayer DN, Tal-Gan Y. Recent Advances in GLP-1 Receptor Agonists for Use in Diabetes Mellitus. Drug Development Research. PMID 28786125 DOI: 10.1002/Ddr.21404 |
0.453 |
|
| 2017 |
McBrayer DN, Gantman BK, Cameron CD, Tal-Gan Y. An Entirely Solid Phase Peptide Synthesis-Based Strategy for Synthesis of Gelatinase Biosynthesis-Activating Pheromone (GBAP) Analogue Libraries: Investigating the Structure-Activity Relationships of the Enterococcus faecalis Quorum Sensing Signal. Organic Letters. PMID 28590764 DOI: 10.1021/Acs.Orglett.7B01444 |
0.488 |
|
| 2017 |
Yang Y, Koirala B, Sanchez LA, Phillips NR, Hamry SR, Tal-Gan Y. Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus Pneumoniae Reveal Motifs Critical for intra-group and cross-group ComD Receptor Activation. Acs Chemical Biology. PMID 28221753 DOI: 10.1021/Acschembio.7B00007 |
0.592 |
|
| 2016 |
Vasquez JK, Tal-Gan Y, Cornilescu G, Tyler KA, Blackwell HE. Simplified AIP-II Peptidomimetics are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. Chembiochem : a European Journal of Chemical Biology. PMID 28006082 DOI: 10.1002/Cbic.201600516 |
0.751 |
|
| 2016 |
Tal-Gan Y, Ivancic M, Cornilescu G, Yang T, Blackwell HE. Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angewandte Chemie (International Ed. in English). PMID 27276693 DOI: 10.1002/Anie.201602974 |
0.713 |
|
| 2016 |
Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. Acs Chemical Biology. PMID 27159024 DOI: 10.1021/Acschembio.6B00120 |
0.732 |
|
| 2015 |
Kratochvil MJ, Tal-Gan Y, Yang T, Blackwell HE, Lynn DM. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. Acs Biomaterials Science & Engineering. 1: 1039-1049. PMID 26501126 DOI: 10.1021/Acsbiomaterials.5B00313 |
0.549 |
|
| 2015 |
Tal-Gan Y, Ivancic M, Cornilescu G, Blackwell HE. Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. Organic & Biomolecular Chemistry. PMID 26416476 DOI: 10.1039/C5Ob01735A |
0.709 |
|
| 2015 |
Levi I, Eskira Y, Eisenstein M, Gilon C, Hoffman A, Tal-Gan Y, Fanous J, Bersudsky Y, Belmaker RH, Agam G, Almog O. Corrigendum to Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioural aspects [Eur. Neuropsychopharmacol., 23, (2013), 1806-1815] Doi: 10.1016/j.euroneuro.2013.02.004 European Neuropsychopharmacology. 25: 2185. DOI: 10.1016/J.Euroneuro.2015.09.003 |
0.469 |
|
| 2014 |
Tal-Gan Y, Stacy DM, Blackwell HE. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. Chemical Communications (Cambridge, England). 50: 3000-3. PMID 24509706 DOI: 10.1039/C4Cc00117F |
0.776 |
|
| 2014 |
Broderick AH, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM. Surface coatings that promote rapid release of peptide-based AgrC inhibitors for attenuation of quorum sensing in Staphylococcus aureus. Advanced Healthcare Materials. 3: 97-105. PMID 23813683 DOI: 10.1002/Adhm.201300119 |
0.78 |
|
| 2013 |
Tal-Gan Y, Ivancic M, Cornilescu G, Cornilescu CC, Blackwell HE. Structural characterization of native autoinducing peptides and abiotic analogues reveals key features essential for activation and inhibition of an AgrC quorum sensing receptor in Staphylococcus aureus. Journal of the American Chemical Society. 135: 18436-44. PMID 24219181 DOI: 10.1021/Ja407533E |
0.745 |
|
| 2013 |
Hurevich M, Ratner-Hurevich M, Tal-Gan Y, Shalev DE, Ben-Sasson SZ, Gilon C. Backbone cyclic helix mimetic of chemokine (C-C motif) receptor 2: a rational approach for inhibiting dimerization of G protein-coupled receptors. Bioorganic & Medicinal Chemistry. 21: 3958-66. PMID 23706536 DOI: 10.1016/J.Bmc.2013.03.019 |
0.596 |
|
| 2013 |
Tal-Gan Y, Stacy DM, Foegen MK, Koenig DW, Blackwell HE. Highly potent inhibitors of quorum sensing in Staphylococcus aureus revealed through a systematic synthetic study of the group-III autoinducing peptide. Journal of the American Chemical Society. 135: 7869-82. PMID 23647400 DOI: 10.1021/Ja3112115 |
0.773 |
|
| 2013 |
Tal-Gan Y, Ivancic M, Cornilescu G, Cornilescu C, Blackwell H. AIP-III_F5A cyclic peptide Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr21039 |
0.709 |
|
| 2012 |
Tal-Gan Y, Naveh S, Klein S, Moshel O, Levitzki A, Gilon C. Studying protein-peptide interactions using benzophenone units: a case study of protein kinase B/Akt and its inhibitor PTR6154. Analytical Biochemistry. 421: 750-4. PMID 22197420 DOI: 10.1016/J.Ab.2011.11.032 |
0.669 |
|
| 2012 |
Naveh S, Tal-Gan Y, Ling S, Hoffman A, Holoshitz J, Gilon C. Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads. Bioorganic & Medicinal Chemistry Letters. 22: 493-6. PMID 22113111 DOI: 10.1016/J.Bmcl.2011.10.098 |
0.641 |
|
| 2012 |
Horwitz E, Tal-Gan Y, Temper V, Shapiro M, Gilon C, Hoffman A. Chemical trapping of vancomycin: a potential strategy for preventing selection of vancomycin-resistant Enterococci. Microbial Drug Resistance (Larchmont, N.Y.). 18: 109-15. PMID 22088148 DOI: 10.1089/Mdr.2011.0057 |
0.566 |
|
| 2011 |
Tal-Gan Y, Freeman NS, Klein S, Levitzki A, Gilon C. Metabolic stability of peptidomimetics: N-methyl and aza heptapeptide analogs of a PKB/Akt inhibitor. Chemical Biology & Drug Design. 78: 887-92. PMID 21824328 DOI: 10.1111/J.1747-0285.2011.01207.X |
0.655 |
|
| 2011 |
Tal-Gan Y, Hurevich M, Klein S, Ben-Shimon A, Rosenthal D, Hazan C, Shalev DE, Niv MY, Levitzki A, Gilon C. Backbone cyclic peptide inhibitors of protein kinase B (PKB/Akt). Journal of Medicinal Chemistry. 54: 5154-64. PMID 21650457 DOI: 10.1021/Jm2003969 |
0.708 |
|
| 2011 |
Freeman NS, Tal-Gan Y, Klein S, Levitzki A, Gilon C. Microwave-assisted solid-phase aza-peptide synthesis: aza scan of a PKB/Akt inhibitor using aza-arginine and aza-proline precursors. The Journal of Organic Chemistry. 76: 3078-85. PMID 21410283 DOI: 10.1021/Jo102422X |
0.707 |
|
| 2010 |
Tal-Gan Y, Freeman NS, Klein S, Levitzki A, Gilon C. Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: the significance of backbone interactions. Bioorganic & Medicinal Chemistry. 18: 2976-85. PMID 20347317 DOI: 10.1016/J.Bmc.2010.02.031 |
0.654 |
|
| 2010 |
Hurevich M, Tal-Gan Y, Klein S, Barda Y, Levitzki A, Gilon C. Novel method for the synthesis of urea backbone cyclic peptides using new Alloc-protected glycine building units. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 178-85. PMID 20196085 DOI: 10.1002/Psc.1218 |
0.702 |
|
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