| Year |
Citation |
Score |
| 2015 |
Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H. Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels. Bioorganic & Medicinal Chemistry. 23: 3655-66. PMID 25922183 DOI: 10.1016/j.bmc.2015.04.014 |
0.96 |
|
| 2015 |
Park KD, Yang XF, Dustrude ET, Wang Y, Ripsch MS, White FA, Khanna R, Kohn H. Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide. Acs Chemical Neuroscience. 6: 316-30. PMID 25418676 DOI: 10.1021/cn5002182 |
0.96 |
|
| 2014 |
Lee H, Park KD, Torregrosa R, Yang XF, Dustrude ET, Wang Y, Wilson SM, Barbosa C, Xiao Y, Cummins TR, Khanna R, Kohn H. Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels. Journal of Medicinal Chemistry. 57: 6165-82. PMID 25004277 DOI: 10.1021/jm500707r |
0.96 |
|
| 2014 |
Kohn H. A mentoring program to help junior faculty members achieve scholarship success. American Journal of Pharmaceutical Education. 78: 29. PMID 24672062 DOI: 10.5688/ajpe78229 |
0.96 |
|
| 2013 |
Lee H, Gold AS, Yang XF, Khanna R, Kohn H. Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity. Bioorganic & Medicinal Chemistry. 21: 7655-62. PMID 24238903 DOI: 10.1016/j.bmc.2013.10.031 |
0.96 |
|
| 2013 |
Lee H, Park KD, Yang XF, Dustrude ET, Wilson SM, Khanna R, Kohn H. (Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents. Journal of Medicinal Chemistry. 56: 5931-9. PMID 23772678 DOI: 10.1021/jm4007092 |
0.96 |
|
| 2013 |
Park KD, Yang XF, Lee H, Dustrude ET, Wang Y, Khanna R, Kohn H. Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. Acs Chemical Neuroscience. 4: 463-74. PMID 23509982 DOI: 10.1021/cn300188h |
0.96 |
|
| 2012 |
King AM, Yang XF, Wang Y, Dustrude ET, Barbosa C, Due MR, Piekarz AD, Wilson SM, White FA, Salomé C, Cummins TR, Khanna R, Kohn H. Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49. PMID 23259039 DOI: 10.1021/cn300129d |
0.96 |
|
| 2012 |
Baruah PK, Dinsmore J, King AM, Salomé C, De Ryck M, Kaminski R, Provins L, Kohn H. Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 20: 3551-64. PMID 22546207 DOI: 10.1016/j.bmc.2012.04.002 |
0.96 |
|
| 2011 |
King AM, De Ryck M, Kaminski R, Valade A, Stables JP, Kohn H. Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. Journal of Medicinal Chemistry. 54: 6432-42. PMID 21861466 DOI: 10.1021/jm200760a |
0.96 |
|
| 2011 |
King AM, Salomé C, Salomé-Grosjean E, De Ryck M, Kaminski R, Valade A, Stables JP, Kohn H. Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Journal of Medicinal Chemistry. 54: 6417-31. PMID 21861463 DOI: 10.1021/jm200759t |
0.96 |
|
| 2011 |
Wang Y, Wilson SM, Brittain JM, Ripsch MS, Salomé C, Park KD, White FA, Khanna R, Kohn H. Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. 2: 317-322. PMID 21765969 DOI: 10.1021/cn200024z |
0.96 |
|
| 2011 |
Park KD, Kim D, Reamtong O, Eyers C, Gaskell SJ, Liu R, Kohn H. Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ. Journal of the American Chemical Society. 133: 11320-30. PMID 21692503 DOI: 10.1021/ja2034156 |
0.96 |
|
| 2011 |
King AM, Salomé C, Dinsmore J, Salomé-Grosjean E, De Ryck M, Kaminski R, Valade A, Kohn H. Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities. Journal of Medicinal Chemistry. 54: 4815-30. PMID 21639114 DOI: 10.1021/jm2004305 |
0.96 |
|
| 2011 |
Wang Y, Park KD, Salome C, Wilson SM, Stables JP, Liu R, Khanna R, Kohn H. Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels. Acs Chemical Neuroscience. 2: 90-106. PMID 21532923 DOI: 10.1021/cn100089b |
0.96 |
|
| 2010 |
Morieux P, Salomé C, Park KD, Stables JP, Kohn H. The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. Journal of Medicinal Chemistry. 53: 5716-26. PMID 20614888 DOI: 10.1021/jm100508m |
0.96 |
|
| 2010 |
Park KD, Stables JP, Liu R, Kohn H. Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group. Organic & Biomolecular Chemistry. 8: 2803-13. PMID 20405068 DOI: 10.1039/c000987c |
0.96 |
|
| 2010 |
Salomé C, Salomé-Grosjean E, Stables JP, Kohn H. Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities. Journal of Medicinal Chemistry. 53: 3756-71. PMID 20394379 DOI: 10.1021/jm100185c |
0.96 |
|
| 2010 |
Salomé C, Salomé-Grosjean E, Park KD, Morieux P, Swendiman R, DeMarco E, Stables JP, Kohn H. Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides. Journal of Medicinal Chemistry. 53: 1288-305. PMID 20041718 DOI: 10.1021/jm901563p |
0.96 |
|
| 2009 |
Salomé C, Kohn H. Triphenylphosphine Dibromide: A Simple One-pot Esterification Reagent. Tetrahedron. 65: 456-460. PMID 20066025 DOI: 10.1016/j.tet.2008.10.062 |
0.96 |
|
| 2009 |
Park KD, Morieux P, Salomé C, Cotten SW, Reamtong O, Eyers C, Gaskell SJ, Stables JP, Liu R, Kohn H. Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. Journal of Medicinal Chemistry. 52: 6897-911. PMID 19795888 DOI: 10.1021/jm9012054 |
0.96 |
|
| 2009 |
Park KD, Liu R, Kohn H. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers. Chemistry & Biology. 16: 763-72. PMID 19635413 DOI: 10.1016/j.chembiol.2009.06.005 |
0.96 |
|
| 2009 |
Lee SH, Kohn H. Nucleophilic activation of a tetra-substituted mitomycin cyclic bis-disulfide. Chemical & Pharmaceutical Bulletin. 57: 149-57. PMID 19182404 DOI: JST.JSTAGE/cpb/57.149 |
0.96 |
|
| 2009 |
Park KD, Liu R, Kohn H. Useful Tools for Biomolecule Isolation, Detection, and Identification: Acylhydrazone-Based Cleavable Linkers (DOI:10.1016/j.chembiol.2009.06.005) Chemistry and Biology. 16: 907. DOI: 10.1016/j.chembiol.2009.08.007 |
0.96 |
|
| 2008 |
Morieux P, Stables JP, Kohn H. Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives. Bioorganic & Medicinal Chemistry. 16: 8968-75. PMID 18789868 DOI: 10.1016/j.bmc.2008.08.055 |
0.96 |
|
| 2007 |
Stöhr T, Kupferberg HJ, Stables JP, Choi D, Harris RH, Kohn H, Walton N, White HS. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Research. 74: 147-54. PMID 17433624 DOI: 10.1016/j.eplepsyres.2007.03.004 |
0.96 |
|
| 2006 |
Zhang S, Golbraikh A, Oloff S, Kohn H, Tropsha A. A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models. Journal of Chemical Information and Modeling. 46: 1984-95. PMID 16995729 DOI: 10.1021/ci060132x |
0.96 |
|
| 2006 |
Park BS, Widger W, Kohn H. Fluorine-substituted dihydrobicyclomycins: synthesis and biochemical and biological properties. Bioorganic & Medicinal Chemistry. 14: 41-61. PMID 16185879 DOI: 10.1016/j.bmc.2005.07.075 |
0.96 |
|
| 2005 |
Duncan GE, Kohn H. The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model. Epilepsy Research. 67: 81-7. PMID 16214306 DOI: 10.1016/j.eplepsyres.2005.08.009 |
0.96 |
|
| 2005 |
Kohn H, Widger W. The molecular basis for the mode of action of bicyclomycin. Current Drug Targets. Infectious Disorders. 5: 273-95. PMID 16181146 DOI: 10.2174/1568005054880136 |
0.96 |
|
| 2005 |
Brogan AP, Widger WR, Bensadek D, Riba-Garcia I, Gaskell SJ, Kohn H. Development of a technique to determine bicyclomycin-rho binding and stoichiometry by isothermal titration calorimetry and mass spectrometry. Journal of the American Chemical Society. 127: 2741-51. PMID 15725032 DOI: 10.1021/ja046441q |
0.96 |
|
| 2005 |
Brogan AP, Verghese J, Widger WR, Kohn H. Bismuth-dithiol inhibition of the Escherichia coli rho transcription termination factor. Journal of Inorganic Biochemistry. 99: 841-51. PMID 15708806 DOI: 10.1016/j.jinorgbio.2004.12.019 |
0.96 |
|
| 2005 |
LeMagueres P, Im H, Ebalunode J, Strych U, Benedik MJ, Briggs JM, Kohn H, Krause KL. The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry. 44: 1471-81. PMID 15683232 DOI: 10.1021/bi0486583 |
0.96 |
|
| 2005 |
Lee SH, Kohn H. 7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin. Organic & Biomolecular Chemistry. 3: 471-82. PMID 15678185 DOI: 10.1039/b414806a |
0.96 |
|
| 2005 |
Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (London, England : 1993). 13: 99-109. PMID 15642265 DOI: 10.1016/j.str.2004.10.013 |
0.96 |
|
| 2005 |
Jin AY, Kohn H, Béguin C, Andurkar SV, Stables JP, Weaver DF. A quantitative structure-activity relationship study for α-substituted acetamido-N-benzylacetamide derivatives - A novel anticonvulsant drug class Canadian Journal of Chemistry. 83: 37-45. DOI: 10.1139/v04-160 |
0.96 |
|
| 2005 |
Lee SH, Brodnick RL, Glish GL, Kohn H. 3,8,11,16-Tetrakis(aminomethyl)-1,2,9,10-tetrathia-cyclohexadecane tetra-trifluoroacetic acid: Synthetic precursor to a novel thio-substituted diamine Tetrahedron. 61: 1749-1754. DOI: 10.1016/j.tet.2004.12.030 |
0.96 |
|
| 2004 |
Béguin C, LeTiran A, Stables JP, Voyksner RD, Kohn H. N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities. Bioorganic & Medicinal Chemistry. 12: 3079-96. PMID 15142567 DOI: 10.1016/j.bmc.2004.02.043 |
0.96 |
|
| 2004 |
Shen M, Béguin C, Golbraikh A, Stables JP, Kohn H, Tropsha A. Application of predictive QSAR models to database mining: identification and experimental validation of novel anticonvulsant compounds. Journal of Medicinal Chemistry. 47: 2356-64. PMID 15084134 DOI: 10.1021/jm030584q |
0.96 |
|
| 2004 |
Kim MG, Bodor ET, Harden TK, Kohn H. C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands. Bioorganic & Medicinal Chemistry. 12: 2357-67. PMID 15080933 DOI: 10.1016/j.bmc.2004.02.016 |
0.96 |
|
| 2004 |
Lee SH, Kohn H. Cyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin. Journal of the American Chemical Society. 126: 4281-92. PMID 15053618 DOI: 10.1021/ja030577r |
0.96 |
|
| 2003 |
Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/ja030452m |
0.96 |
|
| 2003 |
Béguin C, Andurkar SV, Jin AY, Stables JP, Weaver DF, Kohn H. Functionalized amido ketones: new anticonvulsant agents. Bioorganic & Medicinal Chemistry. 11: 4275-85. PMID 12951158 DOI: 10.1016/S0968-0896(03)00434-6 |
0.96 |
|
| 2003 |
Weber TP, Widger WR, Kohn H. Metal-1,4-dithio-2,3-dihydroxybutane chelates: novel inhibitors of the Rho transcription termination factor. Biochemistry. 42: 9121-6. PMID 12885245 DOI: 10.1021/bi030089w |
0.96 |
|
| 2003 |
Brogan AP, Widger WR, Kohn H. Bicyclomycin fluorescent probes: synthesis and biochemical, biophysical, and biological properties. The Journal of Organic Chemistry. 68: 5575-87. PMID 12839449 DOI: 10.1021/jo030020u |
0.96 |
|
| 2003 |
Kim MG, Bodor ET, Wang C, Harden TK, Kohn H. C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. Journal of Medicinal Chemistry. 46: 2216-26. PMID 12747793 DOI: 10.1021/jm020572p |
0.96 |
|
| 2003 |
Kim MG, Strych U, Krause K, Benedik M, Kohn H. N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. The Journal of Antibiotics. 56: 160-8. PMID 12715876 |
0.96 |
|
| 2003 |
Weber TP, Widger WR, Kohn H. Metal dependency for transcription factor rho activation. Biochemistry. 42: 1652-9. PMID 12578379 DOI: 10.1021/bi020601y |
0.96 |
|
| 2003 |
Xu Y, Johnson J, Kohn H, Widger WR. ATP binding to Rho transcription termination factor. Mutant F355W ATP-induced fluorescence quenching reveals dynamic ATP binding. The Journal of Biological Chemistry. 278: 13719-27. PMID 12551938 DOI: 10.1074/jbc.M212979200 |
0.96 |
|
| 2003 |
Kim MG, Strych U, Krause K, Benedik M, Kohn H. Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors Medicinal Chemistry Research. 12: 130-138. |
0.96 |
|
| 2003 |
Lee SH, Kohn H. Phosphine-assisted rearrangement of 4,5-dihydroxy-1,2-dithianes to 4-hydroxy-3-mercaptotetrahydrothiophenes Heterocycles. 60: 47-56. |
0.96 |
|
| 2002 |
Weber TP, Widger WR, Kohn H. The Mg2+ requirements for rho transcription termination factor: catalysis and bicyclomycin inhibition. Biochemistry. 41: 12377-83. PMID 12369827 DOI: 10.1021/bi020420w |
0.96 |
|
| 2002 |
LeTiran A, Stables JP, Kohn H. Design and evaluation of affinity labels of functionalized amino acid anticonvulsants. Journal of Medicinal Chemistry. 45: 4762-73. PMID 12361404 DOI: 10.1021/jm020225f |
0.96 |
|
| 2002 |
Shen M, LeTiran A, Xiao Y, Golbraikh A, Kohn H, Tropsha A. Quantitative structure-activity relationship analysis of functionalized amino acid anticonvulsant agents using k nearest neighbor and simulated annealing PLS methods. Journal of Medicinal Chemistry. 45: 2811-23. PMID 12061883 DOI: 10.1021/jm010488u |
0.96 |
|
| 2002 |
Xu Y, Kohn H, Widger WR. Mutations in the rho transcription termination factor that affect RNA tracking. The Journal of Biological Chemistry. 277: 30023-30. PMID 12034708 DOI: 10.1074/jbc.M111009200 |
0.96 |
|
| 2002 |
Na Y, Wang S, Kohn H. 7-N-(mercaptoalkyl)mitomycins: implications of cyclization for drug function. Journal of the American Chemical Society. 124: 4666-77. PMID 11971715 DOI: 10.1021/ja0124313 |
0.96 |
|
| 2002 |
Lee SH, Kohn H. Efficient synthesis of medium-sized cyclic ether diamines. The Journal of Organic Chemistry. 67: 1692-5. PMID 11871906 DOI: 10.1021/jo0108663 |
0.96 |
|
| 2001 |
Zewail-Foote M, Li VS, Kohn H, Bearss D, Guzman M, Hurley LH. The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent. Chemistry & Biology. 8: 1033-49. PMID 11731295 DOI: 10.1016/S1074-5521(01)00071-0 |
0.96 |
|
| 2001 |
Na Y, Li VS, Nakanishi Y, Bastow KF, Kohn H. Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins. Journal of Medicinal Chemistry. 44: 3453-62. PMID 11585450 DOI: 10.1021/jm010090y |
0.96 |
|
| 2001 |
LeTiran A, Stables JP, Kohn H. Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues. Bioorganic & Medicinal Chemistry. 9: 2693-708. PMID 11557357 DOI: 10.1016/S0968-0896(01)00204-8 |
0.96 |
|
| 2001 |
Li VS, Tang MS, Kohn H. The effect of C(5) cytosine methylation at CpG sequences on mitomycin-DNA bonding profiles. Bioorganic & Medicinal Chemistry. 9: 863-73. PMID 11354669 DOI: 10.1016/S0968-0896(00)00301-1 |
0.96 |
|
| 2001 |
Andurkar SV, Béguin C, Stables JP, Kohn H. Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents. Journal of Medicinal Chemistry. 44: 1475-8. PMID 11311072 DOI: 10.1021/jm000517l |
0.96 |
|
| 2001 |
Vincent F, Srinivasan J, Santillán A, Widger WR, Kohn H. C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties. The Journal of Organic Chemistry. 66: 2251-64. PMID 11281764 DOI: 10.1021/jo0013150 |
0.96 |
|
| 2001 |
Na Y, Kohn H. Quinone-cyclized porfiromycins Heterocycles. 55: 1347-1363. |
0.96 |
|
| 2000 |
Vincent F, Openshaw M, Trautwein M, Gaskell SJ, Kohn H, Widger WR. Rho transcription factor: symmetry and binding of bicyclomycin. Biochemistry. 39: 9077-83. PMID 10924100 DOI: 10.1021/bi000504+ |
0.96 |
|
| 2000 |
Vincent F, Widger WR, Openshaw M, Gaskell SJ, Kohn H. 5a-formylbicyclomycin: studies on the bicyclomycin-Rho interaction. Biochemistry. 39: 9067-76. PMID 10924099 DOI: 10.1021/bi000503h |
0.96 |
|
| 2000 |
Wang C, Kohn H. Formation of aromatic rings through enamine annulation Organic Letters. 2: 1773-5. PMID 10880223 DOI: 10.1021/ol000093p |
0.96 |
|
| 2000 |
Li VS, Reed M, Zheng Y, Kohn H, Tang M. C5 cytosine methylation at CpG sites enhances sequence selectivity of mitomycin C-DNA bonding. Biochemistry. 39: 2612-8. PMID 10704210 DOI: 10.1021/bi991307h |
0.96 |
|
| 1999 |
Andurkar SV, Stables JP, Kohn H. The anticonvulsant activities of N-benzyl 3-methoxypropionamides. Bioorganic & Medicinal Chemistry. 7: 2381-9. PMID 10632047 DOI: 10.1016/S0968-0896(99)00186-8 |
0.96 |
|
| 1999 |
Wang S, Kohn H. Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C. Journal of Medicinal Chemistry. 42: 788-90. PMID 10072677 DOI: 10.1021/jm9806796 |
0.96 |
|
| 1999 |
Magyar A, Zhang X, Abdi F, Kohn H, Widger WR. Identifying the bicyclomycin binding domain through biochemical analysis of antibiotic-resistant rho proteins. The Journal of Biological Chemistry. 274: 7316-24. PMID 10066795 DOI: 10.1074/jbc.274.11.7316 |
0.96 |
|
| 1998 |
Riba I, Gaskell SJ, Cho H, Widger WR, Kohn H. Evidence for the location of bicyclomycin binding to the Escherichia coli transcription termination factor Rho. The Journal of Biological Chemistry. 273: 34033-41. PMID 9852059 DOI: 10.1074/jbc.273.51.34033 |
0.96 |
|
| 1998 |
Santillán A, Zhang X, Hardesty J, Widger WR, Kohn H. Role of the C(6)-hydroxy group in bicyclomycin: synthesis, structure, and chemical, biochemical, and biological properties. Journal of Medicinal Chemistry. 41: 1185-94. PMID 9544218 DOI: 10.1021/jm9708386 |
0.96 |
|
| 1998 |
Santillán A, Zhang X, Widger WR, Kohn H. 5a-methyl-substituted bicyclomycins: Synthesis and chemical, biochemical, and biological properties Journal of Organic Chemistry. 63: 1290-1298. DOI: 10.1021/jo972055y |
0.96 |
|
| 1998 |
Andurkar SV, Stables JP, Kohn H. Synthesis and anticonvulsant activities of (R)-(O)-methylserine derivatives Tetrahedron Asymmetry. 9: 3841-3854. |
0.96 |
|
| 1997 |
Cho H, Park HG, Zhang X, Riba I, Gaskell SJ, Widger WR, Kohn H. Design, syntheses, and evaluations of bicyclomycin-based rho inactivators Journal of Organic Chemistry. 62: 5432-5440. DOI: 10.1021/jo970575n |
0.96 |
|
| 1997 |
Wang S, Kohn H. C(7)-Substituted Diaminomitomycins: Synthesis, Structure, and Chemical Reactivity Journal of Organic Chemistry. 62: 5404-5412. |
0.96 |
|
| 1997 |
Magyar A, Zhang X, Kohn H, Widger WR. Biochemical analysis of bicyclomycin resistant e. coli mutant r ho proteins Faseb Journal. 11: A1147. |
0.96 |
|
| 1997 |
Huh N, Kogan TP, Kohn H. Synthesis of N-substituted 10-des(carbamoyloxy)-10-azidomitomycins Synthesis. 921-924. |
0.96 |
|
| 1996 |
Park Hg, Zhang Z, Zhang X, Widger WR, Kohn H. Role of the C(5)-C(5a) Exomethylene Group in Bicyclomycin: Synthesis, Structure, and Biochemical and Biological Properties. The Journal of Organic Chemistry. 61: 7764-7776. PMID 11667732 DOI: 10.1021/jo961004i |
0.96 |
|
| 1996 |
Santillán A, Park Hg, Zhang X, Lee OS, Widger WR, Kohn H. Role of the [4.2.2] Bicyclic Unit in Bicyclomycin: Synthesis, Structure, Chemical, Biochemical, and Biological Properties. The Journal of Organic Chemistry. 61: 7756-7763. PMID 11667731 DOI: 10.1021/jo961003q |
0.96 |
|
| 1996 |
Park Hg, Zhang X, Widger WR, Kohn H. Role of the C(1) Triol Group in Bicyclomycin: Synthesis and Biochemical and Biological Properties. The Journal of Organic Chemistry. 61: 7750-7755. PMID 11667730 DOI: 10.1021/jo961002y |
0.96 |
|
| 1996 |
Choi D, Stables JP, Kohn H. The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent Bioorganic and Medicinal Chemistry. 4: 2105-2114. PMID 9022975 DOI: 10.1016/S0968-0896(96)00225-8 |
0.96 |
|
| 1996 |
Huh N, Rege AA, Yoo B, Kogan TP, Kohn H. Design, synthesis, and evaluation of mitomycin-tethered phosphorothioate oligodeoxynucleotides Bioconjugate Chemistry. 7: 659-669. PMID 8950485 DOI: 10.1021/bc960060n |
0.96 |
|
| 1996 |
Magyar A, Zhang X, Kohn H, Widger WR. The antibiotic bicyclomycin affects the secondary RNA binding site of Escherichia coli transcription termination factor Rho Journal of Biological Chemistry. 271: 25369-25374. PMID 8810302 DOI: 10.1074/jbc.271.41.25369 |
0.96 |
|
| 1996 |
Choi D, Stables JP, Kohn H. Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives Journal of Medicinal Chemistry. 39: 1907-1916. PMID 8627614 |
0.96 |
|
| 1996 |
Wang S, Kohn H. Mitomycin betaines: Synthesis, structure, and solvolytic reactivity Journal of Organic Chemistry. 61: 9202-9206. DOI: 10.1021/jo961378b |
0.96 |
|
| 1996 |
Li VS, Choi D, Wang Z, Jimenez LS, Tang MS, Kohn H. Role of the C-10 substituent in mitomycin C-1-DNA bonding Journal of the American Chemical Society. 118: 2326-2331. DOI: 10.1021/ja953871v |
0.96 |
|
| 1996 |
Li VS, Choi D, Tang MS, Kohn H. Concerning in vitro mitomycin-DNA alkylation Journal of the American Chemical Society. 118: 3765-3766. DOI: 10.1021/ja953367q |
0.96 |
|
| 1996 |
Kohn H, Wang S. Studies on the mechanism of activation of C(7) ethylenediamine substituted mitomycins. Relevance to the proposed mode of action of BMY-25067 and KW-2149 Tetrahedron Letters. 37: 2337-2340. DOI: 10.1016/0040-4039(96)00279-1 |
0.96 |
|
| 1996 |
Santillán A, Kohn H. Novel ring transformations for 5,5a-dibromobicyclomycin and derivatives Tetrahedron. 52: 833-842. DOI: 10.1016/0040-4020(95)00942-6 |
0.96 |
|
| 1995 |
Li VS, Choi D, Tang MS, Kohn H. Structural requirements for mitomycin C DNA bonding Biochemistry. 34: 7120-7126. PMID 7766622 |
0.96 |
|
| 1995 |
Park Hg, Zhang X, Moon Hs, Zwiefka A, Cox K, Gaskell SJ, Widger WR, Kohn H. Bicyclomycin and Dihydrobicyclomycin Inhibition Kinetics ofEscherichia colirho-Dependent Transcription Termination Factor ATPase Activity Archives of Biochemistry and Biophysics. 323: 447-454. PMID 7487110 DOI: 10.1006/abbi.1995.0066 |
0.96 |
|
| 1995 |
Choi D, Kohn H. Trimethylsilyl halides: Effective reagents for the synthesis of β-halo amino acid derivatives Tetrahedron Letters. 36: 7011-7014. DOI: 10.1016/0040-4039(95)01451-M |
0.96 |
|
| 1995 |
Choi D, Yoo B, Colson KL, Martin GE, Kohn H. C(10) halogen 10-des(carbamoyloxy)porfiromycins: Synthesis, chemistry, and biological activity Journal of Organic Chemistry. 60: 3391-3396. |
0.96 |
|
| 1995 |
Zhang Z, Park HG, Kohn H. Bicyclomycin oxidative transformations. Synthesis and chemical properties of bicyclomycin-5-norketone The Journal of Organic Chemistry. 60: 5346-5351. |
0.96 |
|
| 1994 |
Kohn H, Sawhney KN, Robertson DW, Leander JD. Anticonvulsant properties of N-substituted alpha,alpha-diamino acid derivatives. Journal of Pharmaceutical Sciences. 83: 689-91. PMID 8071822 DOI: 10.1002/jps.2600830519 |
0.96 |
|
| 1994 |
Zhang Z, Kohn H. Chemical, biochemical, and biological studies on select C(1) triol modified bicyclomycins Journal of the American Chemical Society. 116: 9815-9826. DOI: 10.1021/ja00101a001 |
0.96 |
|
| 1981 |
Kohn H, Bean MB, von Rohrscheidt C, Willcott MR, Warnhoff EW. Participation in the formation of iodo ureas from 3-buten-1-ol derivatives. A reinvestigation1 1 Alfred P. Sloan Fellow, 1977-1981. Camille and Henry Dreyfus Teacher-Scholar Grant Recipient, 1977-1982. Tetrahedron. 37: 3195-3201. DOI: 10.1016/S0040-4020(01)98853-2 |
0.96 |
|
| 1978 |
Watkins SF, Kohn H, Bernal I. Crystal and molecular structure of methyl 3-methyl-2-thioxoimidazol- idine-1 -carboxylate. A possible structural analogue for carboxybiotin Journal of the Chemical Society, Perkin Transactions 2. 26-29. DOI: 10.1039/P29780000026 |
0.96 |
|
| 1972 |
Kohn H, Benkovic SJ, Olofson RA. Dependence of mechanism on pH for deuterium-hydrogen exchange in 1-methyltetrazole-5-d. Transition metal ion catalysis of a deprotonation process. Journal of the American Chemical Society. 94: 5759-65. PMID 5053862 DOI: 10.1021/ja00771a037 |
0.96 |
|
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