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Harold Kohn - Publications

Affiliations: 
1973-1999 Chemistry University of Houston, Houston, TX, United States 
 1999- Medicinal Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
biological mechanisms of therapeutic agents
Website:
http://www.chem.unc.edu/research/index.html?display=organic&content=kohn

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Torregrosa R, Yang XF, Dustrude ET, Cummins TR, Khanna R, Kohn H. Chimeric derivatives of functionalized amino acids and α-aminoamides: Compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels. Bioorganic & Medicinal Chemistry. 23: 3655-66. PMID 25922183 DOI: 10.1016/j.bmc.2015.04.014  0.96
2015 Park KD, Yang XF, Dustrude ET, Wang Y, Ripsch MS, White FA, Khanna R, Kohn H. Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamide and safinamide. Acs Chemical Neuroscience. 6: 316-30. PMID 25418676 DOI: 10.1021/cn5002182  0.96
2014 Lee H, Park KD, Torregrosa R, Yang XF, Dustrude ET, Wang Y, Wilson SM, Barbosa C, Xiao Y, Cummins TR, Khanna R, Kohn H. Substituted N-(biphenyl-4'-yl)methyl (R)-2-acetamido-3-methoxypropionamides: potent anticonvulsants that affect frequency (use) dependence and slow inactivation of sodium channels. Journal of Medicinal Chemistry. 57: 6165-82. PMID 25004277 DOI: 10.1021/jm500707r  0.96
2014 Kohn H. A mentoring program to help junior faculty members achieve scholarship success. American Journal of Pharmaceutical Education. 78: 29. PMID 24672062 DOI: 10.5688/ajpe78229  0.96
2013 Lee H, Gold AS, Yang XF, Khanna R, Kohn H. Benzyloxybenzylammonium chlorides: Simple amine salts that display anticonvulsant activity. Bioorganic & Medicinal Chemistry. 21: 7655-62. PMID 24238903 DOI: 10.1016/j.bmc.2013.10.031  0.96
2013 Lee H, Park KD, Yang XF, Dustrude ET, Wilson SM, Khanna R, Kohn H. (Biphenyl-4-yl)methylammonium chlorides: potent anticonvulsants that modulate Na+ currents. Journal of Medicinal Chemistry. 56: 5931-9. PMID 23772678 DOI: 10.1021/jm4007092  0.96
2013 Park KD, Yang XF, Lee H, Dustrude ET, Wang Y, Khanna R, Kohn H. Discovery of lacosamide affinity bait agents that exhibit potent voltage-gated sodium channel blocking properties. Acs Chemical Neuroscience. 4: 463-74. PMID 23509982 DOI: 10.1021/cn300188h  0.96
2012 King AM, Yang XF, Wang Y, Dustrude ET, Barbosa C, Due MR, Piekarz AD, Wilson SM, White FA, Salomé C, Cummins TR, Khanna R, Kohn H. Identification of the benzyloxyphenyl pharmacophore: a structural unit that promotes sodium channel slow inactivation. Acs Chemical Neuroscience. 3: 1037-49. PMID 23259039 DOI: 10.1021/cn300129d  0.96
2012 Baruah PK, Dinsmore J, King AM, Salomé C, De Ryck M, Kaminski R, Provins L, Kohn H. Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides. Bioorganic & Medicinal Chemistry. 20: 3551-64. PMID 22546207 DOI: 10.1016/j.bmc.2012.04.002  0.96
2011 King AM, De Ryck M, Kaminski R, Valade A, Stables JP, Kohn H. Defining the structural parameters that confer anticonvulsant activity by the site-by-site modification of (R)-N'-benzyl 2-amino-3-methylbutanamide. Journal of Medicinal Chemistry. 54: 6432-42. PMID 21861466 DOI: 10.1021/jm200760a  0.96
2011 King AM, Salomé C, Salomé-Grosjean E, De Ryck M, Kaminski R, Valade A, Stables JP, Kohn H. Primary amino acid derivatives: substitution of the 4'-N'-benzylamide site in (R)-N'-benzyl 2-amino-3-methylbutanamide, (R)-N'-benzyl 2-amino-3,3-dimethylbutanamide, and (R)-N'-benzyl 2-amino-3-methoxypropionamide provides potent anticonvulsants with pain-attenuating properties. Journal of Medicinal Chemistry. 54: 6417-31. PMID 21861463 DOI: 10.1021/jm200759t  0.96
2011 Wang Y, Wilson SM, Brittain JM, Ripsch MS, Salomé C, Park KD, White FA, Khanna R, Kohn H. Merging Structural Motifs of Functionalized Amino Acids and α-Aminoamides Results in Novel Anticonvulsant Compounds with Significant Effects on Slow and Fast Inactivation of Voltage-gated Sodium Channels and in the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. 2: 317-322. PMID 21765969 DOI: 10.1021/cn200024z  0.96
2011 Park KD, Kim D, Reamtong O, Eyers C, Gaskell SJ, Liu R, Kohn H. Identification of a lacosamide binding protein using an affinity bait and chemical reporter strategy: 14-3-3 ζ. Journal of the American Chemical Society. 133: 11320-30. PMID 21692503 DOI: 10.1021/ja2034156  0.96
2011 King AM, Salomé C, Dinsmore J, Salomé-Grosjean E, De Ryck M, Kaminski R, Valade A, Kohn H. Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities. Journal of Medicinal Chemistry. 54: 4815-30. PMID 21639114 DOI: 10.1021/jm2004305  0.96
2011 Wang Y, Park KD, Salome C, Wilson SM, Stables JP, Liu R, Khanna R, Kohn H. Development and characterization of novel derivatives of the antiepileptic drug lacosamide that exhibit far greater enhancement in slow inactivation of voltage-gated sodium channels. Acs Chemical Neuroscience. 2: 90-106. PMID 21532923 DOI: 10.1021/cn100089b  0.96
2010 Morieux P, Salomé C, Park KD, Stables JP, Kohn H. The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. Journal of Medicinal Chemistry. 53: 5716-26. PMID 20614888 DOI: 10.1021/jm100508m  0.96
2010 Park KD, Stables JP, Liu R, Kohn H. Proteomic searches comparing two (R)-lacosamide affinity baits: An electrophilic arylisothiocyanate and a photoactivated arylazide group. Organic & Biomolecular Chemistry. 8: 2803-13. PMID 20405068 DOI: 10.1039/c000987c  0.96
2010 Salomé C, Salomé-Grosjean E, Stables JP, Kohn H. Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities. Journal of Medicinal Chemistry. 53: 3756-71. PMID 20394379 DOI: 10.1021/jm100185c  0.96
2010 Salomé C, Salomé-Grosjean E, Park KD, Morieux P, Swendiman R, DeMarco E, Stables JP, Kohn H. Synthesis and anticonvulsant activities of (R)-N-(4'-substituted)benzyl 2-acetamido-3-methoxypropionamides. Journal of Medicinal Chemistry. 53: 1288-305. PMID 20041718 DOI: 10.1021/jm901563p  0.96
2009 Salomé C, Kohn H. Triphenylphosphine Dibromide: A Simple One-pot Esterification Reagent. Tetrahedron. 65: 456-460. PMID 20066025 DOI: 10.1016/j.tet.2008.10.062  0.96
2009 Park KD, Morieux P, Salomé C, Cotten SW, Reamtong O, Eyers C, Gaskell SJ, Stables JP, Liu R, Kohn H. Lacosamide isothiocyanate-based agents: novel agents to target and identify lacosamide receptors. Journal of Medicinal Chemistry. 52: 6897-911. PMID 19795888 DOI: 10.1021/jm9012054  0.96
2009 Park KD, Liu R, Kohn H. Useful tools for biomolecule isolation, detection, and identification: acylhydrazone-based cleavable linkers. Chemistry & Biology. 16: 763-72. PMID 19635413 DOI: 10.1016/j.chembiol.2009.06.005  0.96
2009 Lee SH, Kohn H. Nucleophilic activation of a tetra-substituted mitomycin cyclic bis-disulfide. Chemical & Pharmaceutical Bulletin. 57: 149-57. PMID 19182404 DOI: JST.JSTAGE/cpb/57.149  0.96
2009 Park KD, Liu R, Kohn H. Useful Tools for Biomolecule Isolation, Detection, and Identification: Acylhydrazone-Based Cleavable Linkers (DOI:10.1016/j.chembiol.2009.06.005) Chemistry and Biology. 16: 907. DOI: 10.1016/j.chembiol.2009.08.007  0.96
2008 Morieux P, Stables JP, Kohn H. Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives. Bioorganic & Medicinal Chemistry. 16: 8968-75. PMID 18789868 DOI: 10.1016/j.bmc.2008.08.055  0.96
2007 Stöhr T, Kupferberg HJ, Stables JP, Choi D, Harris RH, Kohn H, Walton N, White HS. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Research. 74: 147-54. PMID 17433624 DOI: 10.1016/j.eplepsyres.2007.03.004  0.96
2006 Zhang S, Golbraikh A, Oloff S, Kohn H, Tropsha A. A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models. Journal of Chemical Information and Modeling. 46: 1984-95. PMID 16995729 DOI: 10.1021/ci060132x  0.96
2006 Park BS, Widger W, Kohn H. Fluorine-substituted dihydrobicyclomycins: synthesis and biochemical and biological properties. Bioorganic & Medicinal Chemistry. 14: 41-61. PMID 16185879 DOI: 10.1016/j.bmc.2005.07.075  0.96
2005 Duncan GE, Kohn H. The novel antiepileptic drug lacosamide blocks behavioral and brain metabolic manifestations of seizure activity in the 6 Hz psychomotor seizure model. Epilepsy Research. 67: 81-7. PMID 16214306 DOI: 10.1016/j.eplepsyres.2005.08.009  0.96
2005 Kohn H, Widger W. The molecular basis for the mode of action of bicyclomycin. Current Drug Targets. Infectious Disorders. 5: 273-95. PMID 16181146 DOI: 10.2174/1568005054880136  0.96
2005 Brogan AP, Widger WR, Bensadek D, Riba-Garcia I, Gaskell SJ, Kohn H. Development of a technique to determine bicyclomycin-rho binding and stoichiometry by isothermal titration calorimetry and mass spectrometry. Journal of the American Chemical Society. 127: 2741-51. PMID 15725032 DOI: 10.1021/ja046441q  0.96
2005 Brogan AP, Verghese J, Widger WR, Kohn H. Bismuth-dithiol inhibition of the Escherichia coli rho transcription termination factor. Journal of Inorganic Biochemistry. 99: 841-51. PMID 15708806 DOI: 10.1016/j.jinorgbio.2004.12.019  0.96
2005 LeMagueres P, Im H, Ebalunode J, Strych U, Benedik MJ, Briggs JM, Kohn H, Krause KL. The 1.9 A crystal structure of alanine racemase from Mycobacterium tuberculosis contains a conserved entryway into the active site. Biochemistry. 44: 1471-81. PMID 15683232 DOI: 10.1021/bi0486583  0.96
2005 Lee SH, Kohn H. 7-N,7'-N'-(1",2"-Dithianyl-3",6"-dimethylenyl)bismitomycin C: synthesis and nucleophilic activation of a dimeric mitomycin. Organic & Biomolecular Chemistry. 3: 471-82. PMID 15678185 DOI: 10.1039/b414806a  0.96
2005 Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (London, England : 1993). 13: 99-109. PMID 15642265 DOI: 10.1016/j.str.2004.10.013  0.96
2005 Jin AY, Kohn H, Béguin C, Andurkar SV, Stables JP, Weaver DF. A quantitative structure-activity relationship study for α-substituted acetamido-N-benzylacetamide derivatives - A novel anticonvulsant drug class Canadian Journal of Chemistry. 83: 37-45. DOI: 10.1139/v04-160  0.96
2005 Lee SH, Brodnick RL, Glish GL, Kohn H. 3,8,11,16-Tetrakis(aminomethyl)-1,2,9,10-tetrathia-cyclohexadecane tetra-trifluoroacetic acid: Synthetic precursor to a novel thio-substituted diamine Tetrahedron. 61: 1749-1754. DOI: 10.1016/j.tet.2004.12.030  0.96
2004 Béguin C, LeTiran A, Stables JP, Voyksner RD, Kohn H. N-Substituted amino acid N'-benzylamides: synthesis, anticonvulsant, and metabolic activities. Bioorganic & Medicinal Chemistry. 12: 3079-96. PMID 15142567 DOI: 10.1016/j.bmc.2004.02.043  0.96
2004 Shen M, Béguin C, Golbraikh A, Stables JP, Kohn H, Tropsha A. Application of predictive QSAR models to database mining: identification and experimental validation of novel anticonvulsant compounds. Journal of Medicinal Chemistry. 47: 2356-64. PMID 15084134 DOI: 10.1021/jm030584q  0.96
2004 Kim MG, Bodor ET, Harden TK, Kohn H. C(8)-substituted 1-azabicyclo[3.3.1]non-3-enes: a novel scaffold for muscarinic receptor ligands. Bioorganic & Medicinal Chemistry. 12: 2357-67. PMID 15080933 DOI: 10.1016/j.bmc.2004.02.016  0.96
2004 Lee SH, Kohn H. Cyclic disulfide C8 iminoporfiromycin: nucleophilic activation of a porfiromycin. Journal of the American Chemical Society. 126: 4281-92. PMID 15053618 DOI: 10.1021/ja030577r  0.96
2003 Vedejs E, Naidu BN, Klapars A, Warner DL, Li VS, Na Y, Kohn H. Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies. Journal of the American Chemical Society. 125: 15796-806. PMID 14677970 DOI: 10.1021/ja030452m  0.96
2003 Béguin C, Andurkar SV, Jin AY, Stables JP, Weaver DF, Kohn H. Functionalized amido ketones: new anticonvulsant agents. Bioorganic & Medicinal Chemistry. 11: 4275-85. PMID 12951158 DOI: 10.1016/S0968-0896(03)00434-6  0.96
2003 Weber TP, Widger WR, Kohn H. Metal-1,4-dithio-2,3-dihydroxybutane chelates: novel inhibitors of the Rho transcription termination factor. Biochemistry. 42: 9121-6. PMID 12885245 DOI: 10.1021/bi030089w  0.96
2003 Brogan AP, Widger WR, Kohn H. Bicyclomycin fluorescent probes: synthesis and biochemical, biophysical, and biological properties. The Journal of Organic Chemistry. 68: 5575-87. PMID 12839449 DOI: 10.1021/jo030020u  0.96
2003 Kim MG, Bodor ET, Wang C, Harden TK, Kohn H. C(8) substituted 1-azabicyclo[3.3.1]non-3-enes and C(8) substituted 1-azabicyclo[3.3.1]nonan-4-ones: novel muscarinic receptor antagonists. Journal of Medicinal Chemistry. 46: 2216-26. PMID 12747793 DOI: 10.1021/jm020572p  0.96
2003 Kim MG, Strych U, Krause K, Benedik M, Kohn H. N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. The Journal of Antibiotics. 56: 160-8. PMID 12715876  0.96
2003 Weber TP, Widger WR, Kohn H. Metal dependency for transcription factor rho activation. Biochemistry. 42: 1652-9. PMID 12578379 DOI: 10.1021/bi020601y  0.96
2003 Xu Y, Johnson J, Kohn H, Widger WR. ATP binding to Rho transcription termination factor. Mutant F355W ATP-induced fluorescence quenching reveals dynamic ATP binding. The Journal of Biological Chemistry. 278: 13719-27. PMID 12551938 DOI: 10.1074/jbc.M212979200  0.96
2003 Kim MG, Strych U, Krause K, Benedik M, Kohn H. Evaluation of amino-substituted heterocyclic derivatives as alanine racemase inhibitors Medicinal Chemistry Research. 12: 130-138.  0.96
2003 Lee SH, Kohn H. Phosphine-assisted rearrangement of 4,5-dihydroxy-1,2-dithianes to 4-hydroxy-3-mercaptotetrahydrothiophenes Heterocycles. 60: 47-56.  0.96
2002 Weber TP, Widger WR, Kohn H. The Mg2+ requirements for rho transcription termination factor: catalysis and bicyclomycin inhibition. Biochemistry. 41: 12377-83. PMID 12369827 DOI: 10.1021/bi020420w  0.96
2002 LeTiran A, Stables JP, Kohn H. Design and evaluation of affinity labels of functionalized amino acid anticonvulsants. Journal of Medicinal Chemistry. 45: 4762-73. PMID 12361404 DOI: 10.1021/jm020225f  0.96
2002 Shen M, LeTiran A, Xiao Y, Golbraikh A, Kohn H, Tropsha A. Quantitative structure-activity relationship analysis of functionalized amino acid anticonvulsant agents using k nearest neighbor and simulated annealing PLS methods. Journal of Medicinal Chemistry. 45: 2811-23. PMID 12061883 DOI: 10.1021/jm010488u  0.96
2002 Xu Y, Kohn H, Widger WR. Mutations in the rho transcription termination factor that affect RNA tracking. The Journal of Biological Chemistry. 277: 30023-30. PMID 12034708 DOI: 10.1074/jbc.M111009200  0.96
2002 Na Y, Wang S, Kohn H. 7-N-(mercaptoalkyl)mitomycins: implications of cyclization for drug function. Journal of the American Chemical Society. 124: 4666-77. PMID 11971715 DOI: 10.1021/ja0124313  0.96
2002 Lee SH, Kohn H. Efficient synthesis of medium-sized cyclic ether diamines. The Journal of Organic Chemistry. 67: 1692-5. PMID 11871906 DOI: 10.1021/jo0108663  0.96
2001 Zewail-Foote M, Li VS, Kohn H, Bearss D, Guzman M, Hurley LH. The inefficiency of incisions of ecteinascidin 743-DNA adducts by the UvrABC nuclease and the unique structural feature of the DNA adducts can be used to explain the repair-dependent toxicities of this antitumor agent. Chemistry & Biology. 8: 1033-49. PMID 11731295 DOI: 10.1016/S1074-5521(01)00071-0  0.96
2001 Na Y, Li VS, Nakanishi Y, Bastow KF, Kohn H. Synthesis, DNA cross-linking activity, and cytotoxicity of dimeric mitomycins. Journal of Medicinal Chemistry. 44: 3453-62. PMID 11585450 DOI: 10.1021/jm010090y  0.96
2001 LeTiran A, Stables JP, Kohn H. Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues. Bioorganic & Medicinal Chemistry. 9: 2693-708. PMID 11557357 DOI: 10.1016/S0968-0896(01)00204-8  0.96
2001 Li VS, Tang MS, Kohn H. The effect of C(5) cytosine methylation at CpG sequences on mitomycin-DNA bonding profiles. Bioorganic & Medicinal Chemistry. 9: 863-73. PMID 11354669 DOI: 10.1016/S0968-0896(00)00301-1  0.96
2001 Andurkar SV, Béguin C, Stables JP, Kohn H. Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents. Journal of Medicinal Chemistry. 44: 1475-8. PMID 11311072 DOI: 10.1021/jm000517l  0.96
2001 Vincent F, Srinivasan J, Santillán A, Widger WR, Kohn H. C(5)-C(5a)-modified bicyclomycins: synthesis, structure, and biochemical and biological properties. The Journal of Organic Chemistry. 66: 2251-64. PMID 11281764 DOI: 10.1021/jo0013150  0.96
2001 Na Y, Kohn H. Quinone-cyclized porfiromycins Heterocycles. 55: 1347-1363.  0.96
2000 Vincent F, Openshaw M, Trautwein M, Gaskell SJ, Kohn H, Widger WR. Rho transcription factor: symmetry and binding of bicyclomycin. Biochemistry. 39: 9077-83. PMID 10924100 DOI: 10.1021/bi000504+  0.96
2000 Vincent F, Widger WR, Openshaw M, Gaskell SJ, Kohn H. 5a-formylbicyclomycin: studies on the bicyclomycin-Rho interaction. Biochemistry. 39: 9067-76. PMID 10924099 DOI: 10.1021/bi000503h  0.96
2000 Wang C, Kohn H. Formation of aromatic rings through enamine annulation Organic Letters. 2: 1773-5. PMID 10880223 DOI: 10.1021/ol000093p  0.96
2000 Li VS, Reed M, Zheng Y, Kohn H, Tang M. C5 cytosine methylation at CpG sites enhances sequence selectivity of mitomycin C-DNA bonding. Biochemistry. 39: 2612-8. PMID 10704210 DOI: 10.1021/bi991307h  0.96
1999 Andurkar SV, Stables JP, Kohn H. The anticonvulsant activities of N-benzyl 3-methoxypropionamides. Bioorganic & Medicinal Chemistry. 7: 2381-9. PMID 10632047 DOI: 10.1016/S0968-0896(99)00186-8  0.96
1999 Wang S, Kohn H. Studies on the mode of action of mitomycin C(7) aminoethylene disulfides (BMS-181174 and KW-2149): reactivity of 7-N-(mercaptoethyl)mitomycin C. Journal of Medicinal Chemistry. 42: 788-90. PMID 10072677 DOI: 10.1021/jm9806796  0.96
1999 Magyar A, Zhang X, Abdi F, Kohn H, Widger WR. Identifying the bicyclomycin binding domain through biochemical analysis of antibiotic-resistant rho proteins. The Journal of Biological Chemistry. 274: 7316-24. PMID 10066795 DOI: 10.1074/jbc.274.11.7316  0.96
1998 Riba I, Gaskell SJ, Cho H, Widger WR, Kohn H. Evidence for the location of bicyclomycin binding to the Escherichia coli transcription termination factor Rho. The Journal of Biological Chemistry. 273: 34033-41. PMID 9852059 DOI: 10.1074/jbc.273.51.34033  0.96
1998 Santillán A, Zhang X, Hardesty J, Widger WR, Kohn H. Role of the C(6)-hydroxy group in bicyclomycin: synthesis, structure, and chemical, biochemical, and biological properties. Journal of Medicinal Chemistry. 41: 1185-94. PMID 9544218 DOI: 10.1021/jm9708386  0.96
1998 Santillán A, Zhang X, Widger WR, Kohn H. 5a-methyl-substituted bicyclomycins: Synthesis and chemical, biochemical, and biological properties Journal of Organic Chemistry. 63: 1290-1298. DOI: 10.1021/jo972055y  0.96
1998 Andurkar SV, Stables JP, Kohn H. Synthesis and anticonvulsant activities of (R)-(O)-methylserine derivatives Tetrahedron Asymmetry. 9: 3841-3854.  0.96
1997 Cho H, Park HG, Zhang X, Riba I, Gaskell SJ, Widger WR, Kohn H. Design, syntheses, and evaluations of bicyclomycin-based rho inactivators Journal of Organic Chemistry. 62: 5432-5440. DOI: 10.1021/jo970575n  0.96
1997 Wang S, Kohn H. C(7)-Substituted Diaminomitomycins: Synthesis, Structure, and Chemical Reactivity Journal of Organic Chemistry. 62: 5404-5412.  0.96
1997 Magyar A, Zhang X, Kohn H, Widger WR. Biochemical analysis of bicyclomycin resistant e. coli mutant r ho proteins Faseb Journal. 11: A1147.  0.96
1997 Huh N, Kogan TP, Kohn H. Synthesis of N-substituted 10-des(carbamoyloxy)-10-azidomitomycins Synthesis. 921-924.  0.96
1996 Park Hg, Zhang Z, Zhang X, Widger WR, Kohn H. Role of the C(5)-C(5a) Exomethylene Group in Bicyclomycin: Synthesis, Structure, and Biochemical and Biological Properties. The Journal of Organic Chemistry. 61: 7764-7776. PMID 11667732 DOI: 10.1021/jo961004i  0.96
1996 Santillán A, Park Hg, Zhang X, Lee OS, Widger WR, Kohn H. Role of the [4.2.2] Bicyclic Unit in Bicyclomycin: Synthesis, Structure, Chemical, Biochemical, and Biological Properties. The Journal of Organic Chemistry. 61: 7756-7763. PMID 11667731 DOI: 10.1021/jo961003q  0.96
1996 Park Hg, Zhang X, Widger WR, Kohn H. Role of the C(1) Triol Group in Bicyclomycin: Synthesis and Biochemical and Biological Properties. The Journal of Organic Chemistry. 61: 7750-7755. PMID 11667730 DOI: 10.1021/jo961002y  0.96
1996 Choi D, Stables JP, Kohn H. The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent Bioorganic and Medicinal Chemistry. 4: 2105-2114. PMID 9022975 DOI: 10.1016/S0968-0896(96)00225-8  0.96
1996 Huh N, Rege AA, Yoo B, Kogan TP, Kohn H. Design, synthesis, and evaluation of mitomycin-tethered phosphorothioate oligodeoxynucleotides Bioconjugate Chemistry. 7: 659-669. PMID 8950485 DOI: 10.1021/bc960060n  0.96
1996 Magyar A, Zhang X, Kohn H, Widger WR. The antibiotic bicyclomycin affects the secondary RNA binding site of Escherichia coli transcription termination factor Rho Journal of Biological Chemistry. 271: 25369-25374. PMID 8810302 DOI: 10.1074/jbc.271.41.25369  0.96
1996 Choi D, Stables JP, Kohn H. Synthesis and anticonvulsant activities of N-benzyl-2-acetamidopropionamide derivatives Journal of Medicinal Chemistry. 39: 1907-1916. PMID 8627614  0.96
1996 Wang S, Kohn H. Mitomycin betaines: Synthesis, structure, and solvolytic reactivity Journal of Organic Chemistry. 61: 9202-9206. DOI: 10.1021/jo961378b  0.96
1996 Li VS, Choi D, Wang Z, Jimenez LS, Tang MS, Kohn H. Role of the C-10 substituent in mitomycin C-1-DNA bonding Journal of the American Chemical Society. 118: 2326-2331. DOI: 10.1021/ja953871v  0.96
1996 Li VS, Choi D, Tang MS, Kohn H. Concerning in vitro mitomycin-DNA alkylation Journal of the American Chemical Society. 118: 3765-3766. DOI: 10.1021/ja953367q  0.96
1996 Kohn H, Wang S. Studies on the mechanism of activation of C(7) ethylenediamine substituted mitomycins. Relevance to the proposed mode of action of BMY-25067 and KW-2149 Tetrahedron Letters. 37: 2337-2340. DOI: 10.1016/0040-4039(96)00279-1  0.96
1996 Santillán A, Kohn H. Novel ring transformations for 5,5a-dibromobicyclomycin and derivatives Tetrahedron. 52: 833-842. DOI: 10.1016/0040-4020(95)00942-6  0.96
1995 Li VS, Choi D, Tang MS, Kohn H. Structural requirements for mitomycin C DNA bonding Biochemistry. 34: 7120-7126. PMID 7766622  0.96
1995 Park Hg, Zhang X, Moon Hs, Zwiefka A, Cox K, Gaskell SJ, Widger WR, Kohn H. Bicyclomycin and Dihydrobicyclomycin Inhibition Kinetics ofEscherichia colirho-Dependent Transcription Termination Factor ATPase Activity Archives of Biochemistry and Biophysics. 323: 447-454. PMID 7487110 DOI: 10.1006/abbi.1995.0066  0.96
1995 Choi D, Kohn H. Trimethylsilyl halides: Effective reagents for the synthesis of β-halo amino acid derivatives Tetrahedron Letters. 36: 7011-7014. DOI: 10.1016/0040-4039(95)01451-M  0.96
1995 Choi D, Yoo B, Colson KL, Martin GE, Kohn H. C(10) halogen 10-des(carbamoyloxy)porfiromycins: Synthesis, chemistry, and biological activity Journal of Organic Chemistry. 60: 3391-3396.  0.96
1995 Zhang Z, Park HG, Kohn H. Bicyclomycin oxidative transformations. Synthesis and chemical properties of bicyclomycin-5-norketone The Journal of Organic Chemistry. 60: 5346-5351.  0.96
1994 Kohn H, Sawhney KN, Robertson DW, Leander JD. Anticonvulsant properties of N-substituted alpha,alpha-diamino acid derivatives. Journal of Pharmaceutical Sciences. 83: 689-91. PMID 8071822 DOI: 10.1002/jps.2600830519  0.96
1994 Zhang Z, Kohn H. Chemical, biochemical, and biological studies on select C(1) triol modified bicyclomycins Journal of the American Chemical Society. 116: 9815-9826. DOI: 10.1021/ja00101a001  0.96
1981 Kohn H, Bean MB, von Rohrscheidt C, Willcott MR, Warnhoff EW. Participation in the formation of iodo ureas from 3-buten-1-ol derivatives. A reinvestigation1 1 Alfred P. Sloan Fellow, 1977-1981. Camille and Henry Dreyfus Teacher-Scholar Grant Recipient, 1977-1982. Tetrahedron. 37: 3195-3201. DOI: 10.1016/S0040-4020(01)98853-2  0.96
1978 Watkins SF, Kohn H, Bernal I. Crystal and molecular structure of methyl 3-methyl-2-thioxoimidazol- idine-1 -carboxylate. A possible structural analogue for carboxybiotin Journal of the Chemical Society, Perkin Transactions 2. 26-29. DOI: 10.1039/P29780000026  0.96
1972 Kohn H, Benkovic SJ, Olofson RA. Dependence of mechanism on pH for deuterium-hydrogen exchange in 1-methyltetrazole-5-d. Transition metal ion catalysis of a deprotonation process. Journal of the American Chemical Society. 94: 5759-65. PMID 5053862 DOI: 10.1021/ja00771a037  0.96
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