| Year |
Citation |
Score |
| 2025 |
de Oliveira RG, Cruz LR, Dessoy MA, Koovits PJ, Dos Santos DA, de Oliveira LFN, Ferreira RA, Mollo MC, Lee E, Duarte SM, Krogh R, Ferreira LLG, Chelucci RC, Dichiara M, Simpson QJ, ... ... Pollastri MP, et al. Discovery and Early Optimization of 1-Indole-2-carboxamides with Anti- Activity. Journal of Medicinal Chemistry. PMID 40163677 DOI: 10.1021/acs.jmedchem.4c02942 |
0.401 |
|
| 2025 |
Spaulding A, Sharma A, Giardini MA, Hoffman B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Millard CC, Devine WG, Singh B, Silva EM, Leed SE, ... ... Pollastri MP, et al. Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents. Acs Infectious Diseases. PMID 39936822 DOI: 10.1021/acsinfecdis.4c00666 |
0.771 |
|
| 2024 |
Ferrins L, Diaz R, Cordon-Obras C, Rojas-Barros D, Quotadamo A, Oehme DP, Ceballos-Pérez G, Swaminathan U, Pérez-Moreno G, Bosch-Navarrete C, García-Hernández R, Gomez-Liñan C, Saura A, Ruiz-Perez LM, Gamarro F, ... ... Pollastri MP, et al. Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of . Journal of Medicinal Chemistry. 67: 13985-14006. PMID 39136694 DOI: 10.1021/acs.jmedchem.4c00785 |
0.77 |
|
| 2023 |
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, ... ... Pollastri MP, et al. Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1304196. PMID 37954236 DOI: 10.3389/fmicb.2023.1304196 |
0.72 |
|
| 2023 |
Dichiara M, Simpson QJ, Quotadamo A, Jalani HB, Huang AX, Millard CC, Klug DM, Tse EG, Todd MH, Silva DG, da Silva Emery F, Carlson JE, Zheng SL, Vleminckx M, Matheeussen A, ... ... Pollastri MP, et al. Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis. Acs Infectious Diseases. PMID 37417544 DOI: 10.1021/acsinfecdis.3c00040 |
0.702 |
|
| 2023 |
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, ... ... Pollastri MP, et al. Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1149145. PMID 37234530 DOI: 10.3389/fmicb.2023.1149145 |
0.746 |
|
| 2023 |
Singh B, Sharma A, Gunaganti N, Rivers M, Gadekar PK, Greene B, Chichioco M, Sanz-Rodriguez CE, Fu C, LeBlanc C, Burchfield E, Sharif N, Hoffman B, Kumar G, Purmal A, ... ... Pollastri MP, et al. Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery. Journal of Medicinal Chemistry. PMID 36695630 DOI: 10.1021/acs.jmedchem.2c01767 |
0.585 |
|
| 2022 |
Sanz-Rodriguez CE, Hoffman B, Guyett PJ, Purmal A, Singh B, Pollastri M, Mensa-Wilmot K. . Molecular Pharmacology. PMID 35605992 DOI: 10.1124/molpharm.121.000430 |
0.455 |
|
| 2021 |
Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, ... ... Pollastri MP, et al. Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 34156862 DOI: 10.1021/acs.jmedchem.1c00674 |
0.826 |
|
| 2020 |
Klug DM, Diaz-Gonzalez R, DeLano TJ, Mavrogiannaki EM, Buskes MJ, Dalton RM, Fisher JK, Schneider KM, Hilborne V, Fritsche MG, Simpson QJ, Tear WF, Devine WG, Pérez-Moreno G, Ceballos-Pérez G, ... ... Pollastri MP, et al. Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity. Rsc Medicinal Chemistry. 11: 950-959. PMID 33479690 DOI: 10.1039/d0md00103a |
0.722 |
|
| 2020 |
Singh B, Diaz-Gonzalez R, Ceballos-Perez G, Rojas-Barros DI, Gunaganti N, Gillingwater K, Martinez-Martinez MS, Manzano P, Navarro M, Pollastri MP. Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Inhibitors. Journal of Medicinal Chemistry. PMID 32786222 DOI: 10.1021/Acs.Jmedchem.0C01017 |
0.644 |
|
| 2020 |
Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. Structure-Bioactivity Relationships of Lapatinib Derived Analogs against . Acs Medicinal Chemistry Letters. 11: 258-265. PMID 32184954 DOI: 10.1021/Acsmedchemlett.9B00455 |
0.774 |
|
| 2020 |
Singh B, Bernatchez JA, McCall LI, Calvet CM, Ackermann J, Souza JM, Thomas D, Silva EM, Bachovchin KA, Klug DM, Jalani HB, Bag S, Buskes MJ, Leed SE, Roncal NE, ... ... Pollastri MP, et al. Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors. Acs Medicinal Chemistry Letters. 11: 249-257. PMID 32184953 DOI: 10.1021/Acsmedchemlett.9B00453 |
0.796 |
|
| 2019 |
Tear W, Bag S, Díaz González R, Ceballos-Perez G, Rojas-Barros DI, Cordon-Obras C, Pérez-Moreno G, García-Hernández R, Martínez-Martínez MS, Ruiz-Perez LM, Gamarro F, Gonzalez-Pacanowska D, Caffrey CR, Ferrins L, Manzano P, ... ... Pollastri MP, et al. Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. Journal of Medicinal Chemistry. PMID 31846577 DOI: 10.1021/Acs.Jmedchem.9B01741 |
0.747 |
|
| 2019 |
Klug DM, Tschiegg L, Díaz González R, Rojas-Barros DI, Perez-Moreno G, Ceballos-Perez G, García-Hernández R, Martínez-Martínez MS, Manzano P, Ruiz-Perez LM, Caffrey CR, Gamarro F, Gonzalez-Pacanowska D, Ferrins L, Navarro M, ... Pollastri MP, et al. Hit-to-lead optimization of benzoxazepinoindazoles as human African trypanosomiasis therapeutics. Journal of Medicinal Chemistry. PMID 31670951 DOI: 10.1021/Acs.Jmedchem.9B01506 |
0.798 |
|
| 2019 |
Klug DM, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, García-Hernández R, Gomez-Pérez V, Ruiz-Pérez LM, Rojas-Barros DI, Gamarro F, González-Pacanowska D, Martínez-Martínez MS, Manzano P, Ferrins L, Caffrey CR, Navarro M, ... Pollastri MP, et al. Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents. Plos Neglected Tropical Diseases. 13: e0007129. PMID 30735501 DOI: 10.1371/Journal.Pntd.0007129 |
0.761 |
|
| 2018 |
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes M, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, et al. Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development. Journal of Medicinal Chemistry. PMID 30565932 DOI: 10.1021/Acs.Jmedchem.8B01365 |
0.776 |
|
| 2018 |
Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Anilinoquinoline based inhibitors of trypanosomatid proliferation. Plos Neglected Tropical Diseases. 12: e0006834. PMID 30475800 DOI: 10.1371/Journal.Pntd.0006834 |
0.788 |
|
| 2018 |
Woodring JL, Behera R, Sharma A, Wiedeman J, Patel G, Singh B, Guyett P, Amata E, Erath J, Roncal N, Penn E, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, ... Pollastri MP, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. Acs Medicinal Chemistry Letters. 9: 996-1001. PMID 30344906 DOI: 10.1021/Acsmedchemlett.8B00245 |
0.823 |
|
| 2018 |
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459]. European Journal of Medicinal Chemistry. 152: 515. PMID 29754075 DOI: 10.1016/J.Ejmech.2018.05.002 |
0.779 |
|
| 2018 |
Absalon S, Blomqvist K, Rudlaff RM, DeLano TJ, Pollastri MP, Dvorin JD. Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in. Mbio. 9. PMID 29487234 DOI: 10.1128/Mbio.00130-18 |
0.388 |
|
| 2018 |
Mehta N, Ferrins L, Leed SE, Sciotti RJ, Pollastri MP. Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation. Acs Infectious Diseases. PMID 29301082 DOI: 10.1021/Acsinfecdis.7B00212 |
0.795 |
|
| 2017 |
Pollastri MP. Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon. Trends in Parasitology. PMID 29275007 DOI: 10.1016/J.Pt.2017.12.002 |
0.327 |
|
| 2017 |
Yuan G, Jankins TC, Patrick CG, Philbrook P, Sears O, Hatfield S, Sitkovsky M, Vasdev N, Liang SH, Ondrechen MJ, Pollastri MP, Jones GB. Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics. International Journal of Medicinal Chemistry. 2017: 4852537. PMID 29201461 DOI: 10.1155/2017/4852537 |
0.321 |
|
| 2017 |
Ferrins L, Pollastri MP. The Importance of Collaboration between Industry, Academics, and Nonprofits in Tropical Disease Drug Discovery. Acs Infectious Diseases. PMID 29134797 DOI: 10.1021/Acsinfecdis.7B00208 |
0.68 |
|
| 2017 |
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation. European Journal of Medicinal Chemistry. 141: 446-459. PMID 29049963 DOI: 10.1016/J.Ejmech.2017.10.007 |
0.821 |
|
| 2017 |
Kunz S, Balmer V, Sterk GJ, Pollastri MP, Leurs R, Müller N, Hemphill A, Spycher C. The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target. Plos Neglected Tropical Diseases. 11: e0005891. PMID 28915270 DOI: 10.1371/Journal.Pntd.0005891 |
0.415 |
|
| 2017 |
Devine W, Thomas SM, Erath J, Bachovchin KA, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, Pollastri MP. Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites. Acs Medicinal Chemistry Letters. 8: 350-354. PMID 28337329 DOI: 10.1021/Acsmedchemlett.7B00011 |
0.565 |
|
| 2017 |
Devine WG, Díaz González R, Ceballos-Perez G, Rojas-Barros DI, Satoh T, Tear W, Ranade RM, Barros-Álvarez X, Hol WG, Buckner FS, Navarro M, Pollastri MP. From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. Acs Infectious Diseases. PMID 28110521 DOI: 10.1021/Acsinfecdis.6B00202 |
0.478 |
|
| 2017 |
Thomas SM, Purmal A, Pollastri M, Mensa-Wilmot K. Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. Scientific Reports. 7: 40565. PMID 28074881 DOI: 10.1038/Srep40565 |
0.538 |
|
| 2016 |
Guyett PJ, Behera R, Ogata Y, Pollastri M, Mensa-Wilmot K. Novel Effects of Lapatinib Revealed in the African Trypanosome using Hypothesis-Generating Proteomics and Chemical Biology Strategies. Antimicrobial Agents and Chemotherapy. PMID 27872081 DOI: 10.1128/Aac.01865-16 |
0.479 |
|
| 2016 |
Guyett PJ, Xia S, Swinney DC, Pollastri MP, Mensa-Wilmot K. Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome. Acs Infectious Diseases. 2: 518-528. PMID 27626104 DOI: 10.1021/Acsinfecdis.6B00077 |
0.403 |
|
| 2016 |
Thomas SM, Purmal A, Pollastri M, Mensa-Wilmot K. Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. Scientific Reports. 6: 32083. PMID 27561392 DOI: 10.1038/srep32083 |
0.446 |
|
| 2016 |
Klug DM, Gelb MH, Pollastri MP. Repurposing strategies for tropical disease drug discovery. Bioorganic & Medicinal Chemistry Letters. PMID 27080183 DOI: 10.1016/J.Bmcl.2016.03.103 |
0.449 |
|
| 2016 |
Amata E, Xi H, Colmenarejo G, Gonzalez-Diaz R, Cordon-Obras C, Berlanga M, Manzano P, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Navarro M, Pollastri MP. Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? Acs Infectious Diseases. 2: 180-186. PMID 26998514 DOI: 10.1021/Acsinfecdis.5B00136 |
0.69 |
|
| 2015 |
Devine W, Woodring JL, Swaminathan U, Amata E, Patel G, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery. Journal of Medicinal Chemistry. 58: 5522-37. PMID 26087257 DOI: 10.1021/Acs.Jmedchem.5B00515 |
0.824 |
|
| 2015 |
Shivanna S, Kolandaivelu K, Shashar M, Belghasim M, Al-Rabadi L, Balcells M, Zhang A, Weinberg J, Francis J, Pollastri MP, Edelman ER, Sherr DH, Chitalia VC. The Aryl Hydrocarbon Receptor is a Critical Regulator of Tissue Factor Stability and an Antithrombotic Target in Uremia. Journal of the American Society of Nephrology : Jasn. PMID 26019318 DOI: 10.1681/Asn.2014121241 |
0.31 |
|
| 2015 |
Amata E, Bland ND, Campbell RK, Pollastri MP. Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Tetrahedron Letters. 56: 2832-2835. PMID 25977593 DOI: 10.1016/J.Tetlet.2015.04.061 |
0.732 |
|
| 2015 |
Kozakov D, Hall DR, Jehle S, Luo L, Ochiana SO, Jones EV, Pollastri M, Allen KN, Whitty A, Vajda S. Ligand deconstruction: Why some fragment binding positions are conserved and others are not. Proceedings of the National Academy of Sciences of the United States of America. 112: E2585-94. PMID 25918377 DOI: 10.1073/Pnas.1501567112 |
0.71 |
|
| 2015 |
Woodring JL, Patel G, Erath J, Behera R, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, Pollastri MP. EVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA. Medchemcomm. 6: 339-346. PMID 25685309 DOI: 10.1039/C4Md00441H |
0.843 |
|
| 2015 |
Ochiana SO, Bland ND, Settimo L, Campbell RK, Pollastri MP. Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei. Chemical Biology & Drug Design. 85: 549-64. PMID 25283372 DOI: 10.1111/Cbdd.12443 |
0.823 |
|
| 2015 |
Kozakov D, Hall DR, Jehle S, Luo L, Ochiana SO, Jones EV, Pollastri M, Allen KN, Whitty A, Vajda S. Correction for "Ligand deconstruction: Why some fragment binding positions are conserved and others are not," Proceedings of the National Academy of Sciences of the United States of America. 112: E3749. DOI: 10.1073/pnas.1511466112 |
0.678 |
|
| 2015 |
Pollastri M. Data sharing for neglected tropical disease drug discovery: Creating a
framework for reducing redundancy and improving global collaboration Annals of Global Health. 81: 196. DOI: 10.1016/J.Aogh.2015.02.951 |
0.367 |
|
| 2014 |
Merritt C, Silva LE, Tanner AL, Stuart K, Pollastri MP. Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites. Chemical Reviews. 114: 11280-304. PMID 26443079 DOI: 10.1021/Cr500197D |
0.507 |
|
| 2014 |
Diaz R, Luengo-Arratta SA, Seixas JD, Amata E, Devine W, Cordon-Obras C, Rojas-Barros DI, Jimenez E, Ortega F, Crouch S, Colmenarejo G, Fiandor JM, Martin JJ, Berlanga M, Gonzalez S, ... ... Pollastri MP, et al. Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign. Plos Neglected Tropical Diseases. 8: e3253. PMID 25340575 DOI: 10.1371/Journal.Pntd.0003253 |
0.743 |
|
| 2014 |
Galvin BD, Li Z, Villemaine E, Poole CB, Chapman MS, Pollastri MP, Wyatt PG, Carlow CK. A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes. Plos Neglected Tropical Diseases. 8: e3145. PMID 25188325 DOI: 10.1371/Journal.Pntd.0003145 |
0.436 |
|
| 2014 |
Parks AJ, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Molecular Pharmacology. 86: 593-608. PMID 25159092 DOI: 10.1124/Mol.114.093369 |
0.414 |
|
| 2014 |
Amata E, Bland ND, Hoyt CT, Settimo L, Campbell RK, Pollastri MP. Repurposing human PDE4 inhibitors for neglected tropical diseases: design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 4084-9. PMID 25127163 DOI: 10.1016/J.Bmcl.2014.07.063 |
0.829 |
|
| 2014 |
Gaun V, Patchen B, Volovetz J, Zhen AW, Andreev A, Pollastri MP, Fraenkel PG. A chemical screen identifies small molecules that regulate hepcidin expression. Blood Cells, Molecules & Diseases. 53: 231-40. PMID 24998898 DOI: 10.1016/J.Bcmd.2014.06.002 |
0.325 |
|
| 2014 |
Pollastri MP. Finding new collaboration models for enabling neglected tropical disease drug discovery. Plos Neglected Tropical Diseases. 8: e2866. PMID 24992488 DOI: 10.1371/Journal.Pntd.0002866 |
0.445 |
|
| 2014 |
Patel G, Roncal NE, Lee PJ, Leed SE, Erath J, Rodriguez A, Sciotti RJ, Pollastri MP. Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery. Medchemcomm. 5: 655-658. PMID 24910766 DOI: 10.1039/C4Md00045E |
0.752 |
|
| 2014 |
Seixas JD, Luengo-Arratta SA, Diaz R, Saldivia M, Rojas-Barros DI, Manzano P, Gonzalez S, Berlanga M, Smith TK, Navarro M, Pollastri MP. Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness. Journal of Medicinal Chemistry. 57: 4834-48. PMID 24805946 DOI: 10.1021/Jm500361R |
0.546 |
|
| 2014 |
Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger J, Sherr DH, Silverstone AE, Hahn ME, McCune JM. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. Plos One. 9: e87877. PMID 24498387 DOI: 10.1371/Journal.Pone.0087877 |
0.717 |
|
| 2014 |
Woodring JL, Pollastri MP. Inhibitors of Protozoan Phosphodiesterases as Potential Therapeutic Approaches for Tropical Diseases Phosphodiesterases and Their Inhibitors. 61: 191-210. DOI: 10.1002/9783527682348.ch12 |
0.781 |
|
| 2013 |
Woodring JL, Bland ND, Ochiana SO, Campbell RK, Pollastri MP. Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1). Bioorganic & Medicinal Chemistry Letters. 23: 5971-4. PMID 24042005 DOI: 10.1016/J.Bmcl.2013.08.057 |
0.829 |
|
| 2013 |
Patel G, Karver CE, Behera R, Guyett PJ, Sullenberger C, Edwards P, Roncal NE, Mensa-Wilmot K, Pollastri MP. Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis. Journal of Medicinal Chemistry. 56: 3820-32. PMID 23597080 DOI: 10.1021/Jm400349K |
0.83 |
|
| 2013 |
Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, Courtemanche G, Devine W, Erath J, Juda CE, Wawrzak Z, Wood JT, Lepesheva GI, Rodriguez A, Pollastri MP. Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth. Journal of Medicinal Chemistry. 56: 2556-67. PMID 23448316 DOI: 10.1021/Jm400012E |
0.726 |
|
| 2013 |
Katiyar S, Kufareva I, Behera R, Thomas SM, Ogata Y, Pollastri M, Abagyan R, Mensa-Wilmot K. Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. Plos One. 8: e56150. PMID 23437089 DOI: 10.1371/Journal.Pone.0056150 |
0.482 |
|
| 2013 |
Ochiana SO, Pandarinath V, Wang Z, Kapoor R, Ondrechen MJ, Ruben L, Pollastri MP. The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing. European Journal of Medicinal Chemistry. 62: 777-84. PMID 22889561 DOI: 10.1016/J.Ejmech.2012.07.038 |
0.842 |
|
| 2012 |
Ochiana SO, Gustafson A, Bland ND, Wang C, Russo MJ, Campbell RK, Pollastri MP. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs. Bioorganic & Medicinal Chemistry Letters. 22: 2582-4. PMID 22377518 DOI: 10.1016/j.bmcl.2012.01.118 |
0.826 |
|
| 2012 |
Wang C, Ashton TD, Gustafson A, Bland ND, Ochiana SO, Campbell RK, Pollastri MP. Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 1. Sildenafil analogs. Bioorganic & Medicinal Chemistry Letters. 22: 2579-81. PMID 22370268 DOI: 10.1016/J.Bmcl.2012.01.119 |
0.84 |
|
| 2011 |
Pollastri MP. Drug discovery in the 21st century. Future Medicinal Chemistry. 3: 1979-81. PMID 22098347 DOI: 10.4155/Fmc.11.151 |
0.396 |
|
| 2011 |
Bland ND, Wang C, Tallman C, Gustafson AE, Wang Z, Ashton TD, Ochiana SO, McAllister G, Cotter K, Fang AP, Gechijian L, Garceau N, Gangurde R, Ortenberg R, Ondrechen MJ, ... ... Pollastri MP, et al. Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. Journal of Medicinal Chemistry. 54: 8188-94. PMID 22023548 DOI: 10.1021/Jm201148S |
0.829 |
|
| 2011 |
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, Madeira da Silva L, Saldivia M, Karver CE, Rodriguez A, Beverley SM, Navarro M, Pollastri MP. The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing. Plos Neglected Tropical Diseases. 5: e1297. PMID 21886855 DOI: 10.1371/Journal.Pntd.0001297 |
0.825 |
|
| 2011 |
Pollastri MP, Campbell RK. Target repurposing for neglected diseases. Future Medicinal Chemistry. 3: 1307-15. PMID 21859304 DOI: 10.4155/Fmc.11.92 |
0.442 |
|
| 2011 |
Anderson AC, Pollastri MP, Schiffer CA, Peet NP. The challenge of developing robust drugs to overcome resistance. Drug Discovery Today. 16: 755-61. PMID 21784168 DOI: 10.1016/J.Drudis.2011.07.001 |
0.361 |
|
| 2011 |
Doan TL, Pollastri M, Walters MA, Georg GI. The Future of Drug Repositioning. Old Drugs, New Opportunities Annual Reports in Medicinal Chemistry. 46: 385-401. DOI: 10.1016/B978-0-12-386009-5.00004-7 |
0.328 |
|
| 2010 |
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