| Year |
Citation |
Score |
| 2013 |
Yang D, Arifhodzic L, Ganellin CR, Jenkinson DH. Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels. European Journal of Medicinal Chemistry. 63: 907-23. PMID 23685886 DOI: 10.1016/J.Ejmech.2013.02.029 |
0.345 |
|
| 2011 |
Ganellin CR. Personal reflections on Sir James Black (1924-2010) and histamine. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 60: 103-10. PMID 20978923 DOI: 10.1007/S00011-010-0269-2 |
0.397 |
|
| 2008 |
Levoin N, Calmels T, Poupardin-Olivier O, Labeeuw O, Danvy D, Robert P, Berrebi-Bertrand I, Ganellin CR, Schunack W, Stark H, Capet M. Refined docking as a valuable tool for lead optimization: application to histamine H3 receptor antagonists. Archiv Der Pharmazie. 341: 610-23. PMID 18816585 DOI: 10.1002/Ardp.200800042 |
0.365 |
|
| 2008 |
Das BC, Madhukumar AV, Anguiano J, Kim S, Sinz M, Zvyaga TA, Power EC, Ganellin CR, Mani S. Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bioorganic & Medicinal Chemistry Letters. 18: 3974-7. PMID 18583127 DOI: 10.1016/J.Bmcl.2008.06.018 |
0.356 |
|
| 2007 |
Fletcher DI, Ganellin CR, Piergentili A, Dunn PM, Jenkinson DH. Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). Bioorganic & Medicinal Chemistry. 15: 5457-79. PMID 17560109 DOI: 10.1016/J.Bmc.2007.05.054 |
0.336 |
|
| 2006 |
Shah MM, Javadzadeh-Tabatabaie M, Benton DC, Ganellin CR, Haylett DG. Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Molecular Pharmacology. 70: 1494-502. PMID 16877678 DOI: 10.1124/Mol.106.026625 |
0.311 |
|
| 2006 |
Parsons ME, Ganellin CR. Histamine and its receptors. British Journal of Pharmacology. 147: S127-35. PMID 16402096 DOI: 10.1038/Sj.Bjp.0706440 |
0.389 |
|
| 2006 |
Power EC, Ganellin CR, Benton DC. Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)). Bioorganic & Medicinal Chemistry Letters. 16: 887-90. PMID 16359866 DOI: 10.1016/J.Bmcl.2005.11.001 |
0.301 |
|
| 2005 |
Apelt J, Grassmann S, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Search for histamine H3 receptor antagonists with combined inhibitory potency at Ntau-methyltransferase: ether derivatives. Die Pharmazie. 60: 97-106. PMID 15739896 |
0.364 |
|
| 2004 |
Grassmann S, Apelt J, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Search for histamine H(3) receptor ligands with combined inhibitory potency at histamine N-methyltransferase: omega-piperidinoalkanamine derivatives. Archiv Der Pharmazie. 337: 533-45. PMID 15476285 DOI: 10.1002/Ardp.200400897 |
0.326 |
|
| 2004 |
Pelloux-Léon N, Fkyerat A, Piripitsi A, Tertiuk W, Schunack W, Stark H, Garbarg M, Ligneau X, Arrang JM, Schwartz JC, Ganellin CR. Meta-substituted aryl(thio)ethers as potent partial agonists (or antagonists) for the histamine H3 receptor lacking a nitrogen atom in the side chain. Journal of Medicinal Chemistry. 47: 3264-74. PMID 15163206 DOI: 10.1021/Jm031141P |
0.321 |
|
| 2004 |
Meier G, Krause M, Hüls A, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. 4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists. Journal of Medicinal Chemistry. 47: 2678-87. PMID 15115409 DOI: 10.1021/Jm031065Q |
0.434 |
|
| 2004 |
Mikó T, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists. Bioorganic & Medicinal Chemistry. 12: 2727-36. PMID 15110854 DOI: 10.1016/J.Bmc.2004.03.009 |
0.443 |
|
| 2004 |
Dougalis A, Lees G, Ganellin CR. The sleep lipid oleamide may represent an endogenous anticonvulsant: an in vitro comparative study in the 4-aminopyridine rat brain-slice model. Neuropharmacology. 46: 541-54. PMID 14975678 DOI: 10.1016/J.Neuropharm.2003.10.011 |
0.303 |
|
| 2004 |
Narenjkar J, Assem el-SK, Ganellin CR. Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues. European Journal of Pharmacology. 483: 107-16. PMID 14729097 DOI: 10.1016/J.Ejphar.2003.10.014 |
0.321 |
|
| 2003 |
Gbahou F, Rouleau A, Morisset S, Parmentier R, Crochet S, Lin JS, Ligneau X, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. Protean agonism at histamine H3 receptors in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 11086-91. PMID 12960366 DOI: 10.1073/Pnas.1932276100 |
0.374 |
|
| 2003 |
Grassmann S, Apelt J, Sippl W, Ligneau X, Pertz HH, Zhao YH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Imidazole derivatives as a novel class of hybrid compounds with inhibitory histamine N-methyltransferase potencies and histamine hH3 receptor affinities. Bioorganic & Medicinal Chemistry. 11: 2163-74. PMID 12713826 DOI: 10.1016/S0968-0896(03)00120-2 |
0.438 |
|
| 2003 |
Mikó T, Ligneau X, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Novel nonimidazole histamine H3 receptor antagonists: 1-(4-(phenoxymethyl)benzyl)piperidines and related compounds. Journal of Medicinal Chemistry. 46: 1523-30. PMID 12672253 DOI: 10.1021/Jm021084K |
0.449 |
|
| 2002 |
Sasse A, Ligneau X, Rouleau A, Elz S, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Influence of bulky substituents on histamine h(3) receptor agonist/antagonist properties. Journal of Medicinal Chemistry. 45: 4000-10. PMID 12190321 DOI: 10.1021/Jm020910M |
0.433 |
|
| 2002 |
Zunszain PA, Shah MM, Miscony Z, Javadzadeh-Tabatabaie M, Haylett DG, Ganellin CR. Tritylamino aromatic heterocycles and related carbinols as blockers of ca 2+-activated potassium ion channels underlying neuronal hyperpolarization. Archiv Der Pharmazie. 335: 159-66. PMID 12112036 DOI: 10.1002/1521-4184(200204)335:4<159::Aid-Ardp159>3.0.Co;2-K |
0.332 |
|
| 2002 |
Meier G, Ligneau X, Pertz HH, Ganellin CR, Schwartz JC, Schunack W, Stark H. Piperidino-hydrocarbon compounds as novel non-imidazole histamine H(3)-receptor antagonists. Bioorganic & Medicinal Chemistry. 10: 2535-42. PMID 12057642 DOI: 10.1016/S0968-0896(02)00115-3 |
0.397 |
|
| 2002 |
Grassmann S, Sadek B, Ligneau X, Elz S, Ganellin CR, Arrang JM, Schwartz JC, Stark H, Schunack W. Progress in the proxifan class: heterocyclic congeners as novel potent and selective histamine H(3)-receptor antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 15: 367-78. PMID 11988398 DOI: 10.1016/S0928-0987(02)00024-6 |
0.435 |
|
| 2002 |
Apelt J, Ligneau X, Pertz HH, Arrang JM, Ganellin CR, Schwartz JC, Schunack W, Stark H. Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. Journal of Medicinal Chemistry. 45: 1128-41. PMID 11855993 DOI: 10.1021/Jm0110845 |
0.446 |
|
| 2001 |
Stark H, Arrang JM, Ligneau X, Garbarg M, Ganellin CR, Schwartz JC, Schunack W. The histamine H3 receptor and its ligands. Progress in Medicinal Chemistry. 38: 279-308. PMID 11774797 DOI: 10.1016/S0079-6468(08)70096-1 |
0.396 |
|
| 2001 |
Meier G, Apelt J, Reichert U, Grassmann S, Ligneau X, Elz S, Leurquin F, Ganellin CR, Schwartz JC, Schunack W, Stark H. Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 13: 249-59. PMID 11384847 DOI: 10.1016/S0928-0987(01)00106-3 |
0.417 |
|
| 2001 |
Stark H, Sippl W, Ligneau X, Arrang JM, Ganellin CR, Schwartz JC, Schunack W. Different antagonist binding properties of human and rat histamine H3 receptors. Bioorganic & Medicinal Chemistry Letters. 11: 951-4. PMID 11294398 DOI: 10.1016/S0960-894X(01)00090-7 |
0.392 |
|
| 2001 |
Sasse A, Ligneau X, Sadek B, Elz S, Pertz HH, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. Benzophenone derivatives and related compounds as potent histamine H3-receptor antagonists and potential PET/SPECT ligands. Archiv Der Pharmazie. 334: 45-52. PMID 11268774 DOI: 10.1002/1521-4184(200102)334:2<45::AID-ARDP45>3.0.CO;2-2 |
0.352 |
|
| 2001 |
Nicholson RA, Zheng J, Ganellin CR, Verdon B, Lees G. Anesthetic-like interaction of the sleep-inducing lipid oleamide with voltage-gated sodium channels in mammalian brain. Anesthesiology. 94: 120-8. PMID 11135731 DOI: 10.1097/00000542-200101000-00022 |
0.309 |
|
| 2000 |
Kieć-Kononowicz K, Wiecek M, Sasse A, Ligneau X, Elz S, Ganellin CR, Schwartz JC, Stark H, Schunack W. Importance of the lipophilic group in carbamates having histamine H3-receptor antagonist activity. Die Pharmazie. 55: 349-55. PMID 11828613 |
0.329 |
|
| 2000 |
Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM. High constitutive activity of native H3 receptors regulates histamine neurons in brain. Nature. 408: 860-4. PMID 11130725 DOI: 10.1038/35048583 |
0.372 |
|
| 2000 |
Stark H, Ligneau X, Sadek B, Ganellin CR, Arrang JM, Schwartz JC, Schunack W. Analogues and derivatives of ciproxifan, a novel prototype for generating potent histamine H3-receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 10: 2379-82. PMID 11055360 DOI: 10.1016/S0960-894X(00)00473-X |
0.428 |
|
| 2000 |
Stark H, Sadek B, Krause M, Hüls A, Ligneau X, Ganellin CR, Arrang JM, Schwartz JC, Schunack W. Novel histamine H(3)-receptor antagonists with carbonyl-substituted 4-(3-(phenoxy)propyl)-1H-imidazole structures like ciproxifan and related compounds. Journal of Medicinal Chemistry. 43: 3987-94. PMID 11052804 DOI: 10.1021/jm000966l |
0.356 |
|
| 2000 |
Sasse A, Sadek B, Ligneau X, Elz S, Pertz HH, Luger P, Ganellin CR, Arrang JM, Schwartz JC, Schunack W, Stark H. New histamine H(3)-receptor ligands of the proxifan series: imoproxifan and other selective antagonists with high oral in vivo potency. Journal of Medicinal Chemistry. 43: 3335-43. PMID 10966752 DOI: 10.1021/Jm000971P |
0.348 |
|
| 2000 |
Sasse A, Stark H, Ligneau X, Elz S, Reidemeister S, Ganellin CR, Schwartz JC, Schunack W. (Partial) agonist/antagonist properties of novel diarylalkyl carbamates on histamine H3 receptors. Bioorganic & Medicinal Chemistry. 8: 1139-49. PMID 10882024 DOI: 10.1016/S0968-0896(00)00050-X |
0.435 |
|
| 2000 |
Reidemeister S, Stark H, Ligneau X, Ganellin CR, Schwartz JC, Schunack W. Substituted N-phenylcarbamates as histamine H3 receptor antagonists with improved in vivo potency. Die Pharmazie. 55: 83-6. PMID 10723763 |
0.333 |
|
| 1999 |
Sasse A, Stark H, Reidemeister S, Hüls A, Elz S, Ligneau X, Ganellin CR, Schwartz JC, Schunack W. Novel partial agonists for the histamine H(3) receptor with high in vitro and in vivo activity. Journal of Medicinal Chemistry. 42: 4269-74. PMID 10514298 DOI: 10.1021/Jm991068W |
0.343 |
|
| 1999 |
Sasse A, Kiec-Kononowicz K, Stark H, Motyl M, Reidemeister S, Ganellin CR, Ligneau X, Schwartz JC, Schunack W. Development of chiral N-alkylcarbamates as new leads for potent and selective H3-receptor antagonists: synthesis, capillary electrophoresis, and in vitro and oral in vivo activity. Journal of Medicinal Chemistry. 42: 593-600. PMID 10052966 DOI: 10.1021/jm9804376 |
0.35 |
|
| 1997 |
Campos Rosa J, Beckwith-Hall BM, Galanakis D, Ganellin CR, Dunn PM, Jenkinson DH. Bis-quinolinium cyclophanes: A novel class of potent blockers of the apamin-sensitive Ca2+-activated K+ channel Bioorganic and Medicinal Chemistry Letters. 7: 7-10. DOI: 10.1016/S0960-894X(96)00568-9 |
0.316 |
|
| 1996 |
Galanakis D, Ganellin CR, Malik S, Dunn PM. Synthesis and pharmacological testing of dequalinium analogues as blockers of the apamin-sensitive Ca(2+)-activated K+ channel: variation of the length of the alkylene chain. Journal of Medicinal Chemistry. 39: 3592-5. PMID 8784458 DOI: 10.1021/Jm950838A |
0.334 |
|
| 1995 |
Ganellin CR, Fkyerat A, Hosseini SK, Khalaf YS, Piripitsi A, Tertiuk W, Arrang JM, Garbarg M, Ligneau X, Schwartz JC. Structure-activity studies with histamine H3-receptor ligands. Journal De Pharmacie De Belgique. 50: 179-87. PMID 7674117 |
0.341 |
|
| 1995 |
Ganellin CR, Hosseini SK, Khalaf YS, Tertiuk W, Arrang JM, Garbarg M, Ligneau X, Schwartz JC. Design of potent non-thiourea H3-receptor histamine antagonists. Journal of Medicinal Chemistry. 38: 3342-50. PMID 7650687 |
0.315 |
|
| 1995 |
Sorba G, Tertiuk W, Ganellin CR. Synthesis and authentication of iodoazidophenpyramine, a photoaffinity reporter ligand previously used for histamine H1-receptor labelling Archiv Der Pharmazie. 328: 677-680. DOI: 10.1002/Ardp.19953280909 |
0.382 |
|
| 1991 |
Cooper DG, Durant GJ, Ganellin CR, Ife RJ, Meeson ML, Sach GS. Structure-activity studies of pyridinylalkyl-isocytosine H1-receptor antihistamines and identification of an active conformation. Farmaco (Società Chimica Italiana : 1989). 46: 3-19. PMID 1675853 |
0.331 |
|
| 1991 |
Ganellin CR, Jayes D, Khalaf YS, Tertiuk W, Arrang J, Defontaine N, Schwartz J. Synthesis of pyridyl isosteres of thioperamide as H3-receptor histamine antagonists Collection of Czechoslovak Chemical Communications. 56: 2448-2455. DOI: 10.1135/Cccc19912448 |
0.431 |
|
| 1989 |
Ife RJ, Catchpole KW, Durant GJ, Ganellin CR, Harvey CA, Meeson ML, Owen DAA, Parsons ME, Slingsby BP, Theobald CJ. Non-basic histamine H1-antagonists. I: Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds European Journal of Medicinal Chemistry. 24: 249-257. DOI: 10.1016/0223-5234(89)90006-8 |
0.444 |
|
| 1988 |
Brown TH, Blakemore RC, Durant GJ, Emmett JC, Ganellin CR, Parsons ME, Rawlings DA, Walker TF. Isocytosine H2-receptor histamine antagonists I. Oxmetidine and related compounds European Journal of Medicinal Chemistry. 23: 53-62. DOI: 10.1016/0223-5234(88)90167-5 |
0.395 |
|
| 1987 |
Young RC, Ganellin CR, Graham MJ, Mitchell RC, Roantree ML, Tashma Z. Zwitterionic analogues of cimetidine as H2 receptor antagonists. Journal of Medicinal Chemistry. 30: 1150-6. PMID 2885416 |
0.319 |
|
| 1987 |
Blakemore RC, Ganellin CR, Garbarg M, Gros C, Ife RJ, Körner M, Ruat M, Schwartz JC, Tertiuk W, Theobald CJ. Iodobolpyramine and other iodinated derivatives as ligands for detecting histamine H1 receptors European Journal of Medicinal Chemistry. 22: 91-100. DOI: 10.1016/0223-5234(87)90002-X |
0.419 |
|
| 1986 |
Korner M, Bouthenet ML, Ganellin CR, Garbarg M, Gros C, Ife RJ, Sales N, Schwartz JC. [125I]Iodobolpyramine, a highly sensitive probe for histamine H1-receptors in guinea-pig brain. European Journal of Pharmacology. 120: 151-60. PMID 3948916 DOI: 10.1016/0014-2999(86)90535-2 |
0.403 |
|
| 1986 |
Young RC, Durant GJ, Emmett JC, Ganellin CR, Graham MJ, Mitchell RC, Prain HD, Roantree ML. Dipole moment in relation to H2 receptor histamine antagonist activity for cimetidine analogues Journal of Medicinal Chemistry. 29: 44-49. PMID 3941412 DOI: 10.1021/jm00151a007 |
0.322 |
|
| 1985 |
Durant GJ, Ganellin CR, Hills DW, Miles PD, Parsons ME, Pepper ES, White GR. The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations. Journal of Medicinal Chemistry. 28: 1414-22. PMID 2931524 |
0.302 |
|
| 1982 |
Durant G, Ganellin C, R Owen G, Young R. 4333946 Blocking histamine H2-receptors with imidazolylalkyl guanidine derivatives General Pharmacology: the Vascular System. 13: vi. DOI: 10.1016/0306-3623(82)90136-7 |
0.3 |
|
| 1982 |
Young RC, Ganellin CR, Graham MJ, Grant EH. The dipole moments of 1,3-dimethylthiourea, 1,3-dimethyl-2-cyanoguanidine and 1,1-bis-methylamino-2-nitroethene in a aqueous solution Tetrahedron. 38: 1493-1497. DOI: 10.1016/0040-4020(82)80236-6 |
0.335 |
|
| 1980 |
Smith IR, Cleverley MT, Ganellin CR, Metters KM. Binding of [3H]cimetidine to rat brain tissue. Agents and Actions. 10: 422-6. PMID 6111196 DOI: 10.1007/Bf01968040 |
0.353 |
|
| 1979 |
Ganellin CR. Chapter 10 Histamine Receptors Annual Reports in Medicinal Chemistry. 14: 91-102. DOI: 10.1016/S0065-7743(08)61355-X |
0.409 |
|
| 1976 |
Durant GJ, Emmett JC, Ganellin CR, Roe AM, Slater RA. Potential histamine H2-receptor antagonists. 3. Methylhistamines Journal of Medicinal Chemistry. 19: 923-928. PMID 7675 |
0.322 |
|
| 1976 |
Ganellin CR, Durant GJ, Emmett JC. Some chemical aspects of histamine H2 receptor antagonists Federation Proceedings. 35: 1924-1930. PMID 5312 |
0.324 |
|
| 1975 |
Levi R, Ganellin CR, Allan G, Willens HJ. Selective impairment of atrioventricular conduction by 2-(2-pyridyl)-ethylamine and 2-(2-thiazolyl)-ethylamine, two histamine H1-receptor agonists European Journal of Pharmacology. 34: 237-240. PMID 1234767 DOI: 10.1016/0014-2999(75)90246-0 |
0.388 |
|
| 1975 |
Durant GJ, Ganellin CR, Parsons ME. Chemical differentiation of histamine H1- and H2-receptor agonists Journal of Medicinal Chemistry. 18: 905-909. PMID 240025 DOI: 10.1021/Jm00243A009 |
0.403 |
|
| 1963 |
Cope AC, Ganellin CR, Johnson HW, Van Auken TV, Winkler HJS. Molecular asymmetry of olefins. I. Resolution of trans-cyclooctene Journal of the American Chemical Society. 85: 3276-3279. DOI: 10.1021/Ja00903A049 |
0.398 |
|
| 1962 |
Cope AC, Ganellin CR, Johnson HW. Resolution of trans-cycloöctene; confirmation of the asymmetry of cis-trans-1,5-cycloöctadiene [7] Journal of the American Chemical Society. 84: 3191-3192. DOI: 10.1021/Ja00875A036 |
0.387 |
|
| 1958 |
Ganellin CR, Pettit R. 112. Rearrangements of some cyclooctatetraene derivatives Journal of the Chemical Society (Resumed). 576-581. DOI: 10.1039/JR9580000576 |
0.484 |
|
| 1958 |
Dewar MJS, Ganellin CR, Pettit R. 12. The tropylium ion. Part III. Oxidation of cyclohepta-2:4:6- trienecarboxylic acid Journal of the Chemical Society (Resumed). 55-58. DOI: 10.1039/JR9580000055 |
0.458 |
|
| 1957 |
Ganellin CR, Pettit R. OXIDATION OF CYCLOÖCTATETRAENE TO THE TROPYLIUM CATION Journal of the American Chemical Society. 79: 1767-1768. DOI: 10.1021/ja01564a070 |
0.454 |
|
| 1957 |
Ganellin CR, Pettit R. Notiz zur Oxydation des Cyclooctatetraens Chemische Berichte. 90: 2951-2951. DOI: 10.1002/cber.19570901236 |
0.434 |
|
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