| Year |
Citation |
Score |
| 2020 |
Tran AP, Ali Al-Radhawi M, Kareva I, Wu J, Waxman DJ, Sontag ED. Delicate Balances in Cancer Chemotherapy: Modeling Immune Recruitment and Emergence of Systemic Drug Resistance. Frontiers in Immunology. 11: 1376. PMID 32695118 DOI: 10.3389/Fimmu.2020.01376 |
0.325 |
|
| 2020 |
Matthews BJ, Waxman DJ. Impact of 3D genome organization, guided by cohesin and CTCF looping, on sex-biased chromatin interactions and gene expression in mouse liver. Epigenetics & Chromatin. 13: 30. PMID 32680543 DOI: 10.1186/S13072-020-00350-Y |
0.326 |
|
| 2020 |
Lau-Corona D, Bae WK, Hennighausen L, Waxman DJ. Sex-biased genetic programs in liver metabolism and liver fibrosis are controlled by EZH1 and EZH2. Plos Genetics. 16: e1008796. PMID 32428001 DOI: 10.1371/Journal.Pgen.1008796 |
0.356 |
|
| 2020 |
Karri K, Waxman DJ. Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31926019 DOI: 10.1093/Toxsci/Kfaa001 |
0.359 |
|
| 2019 |
Du B, Waxman DJ. Medium Dose Intermittent Cyclophosphamide Induces Immunogenic Cell Death and Cancer Cell Autonomous Type I Interferon Production in Glioma Models. Cancer Letters. PMID 31765733 DOI: 10.1016/J.Canlet.2019.11.025 |
0.366 |
|
| 2019 |
Rampersaud A, Lodato NJ, Shin A, Waxman DJ. Widespread epigenetic changes to the enhancer landscape of mouse liver induced by a specific xenobiotic agonist ligand of the nuclear receptor CAR. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31236583 DOI: 10.1093/Toxsci/Kfz148 |
0.377 |
|
| 2019 |
Melia T, Waxman DJ. Sex-biased lncRNAs inversely correlate with sex-opposite gene co-expression networks in Diversity Outbred mouse liver. Endocrinology. PMID 30840070 DOI: 10.1210/En.2018-00949 |
0.369 |
|
| 2018 |
Matthews BJ, Waxman DJ. Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver. Elife. 7. PMID 29757144 DOI: 10.7554/Elife.34077 |
0.31 |
|
| 2018 |
Lodato NJ, Rampersaud A, Waxman DJ. Impact of CAR agonist ligand TCPOBOP on mouse liver chromatin accessibility. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29617930 DOI: 10.1093/Toxsci/Kfy070 |
0.343 |
|
| 2018 |
Wu J, Waxman DJ. Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy. Cancer Letters. 419: 210-221. PMID 29414305 DOI: 10.1016/J.Canlet.2018.01.050 |
0.367 |
|
| 2018 |
Hao P, Waxman DJ. Functional roles of sex-biased, growth hormone-regulated microRNAs miR-1948 and miR-802 in young adult mouse liver. Endocrinology. PMID 29346554 DOI: 10.1210/En.2017-03109 |
0.305 |
|
| 2018 |
Matthews BJ, Waxman DJ. Author response: Computational prediction of CTCF/cohesin-based intra-TAD loops that insulate chromatin contacts and gene expression in mouse liver Elife. DOI: 10.7554/Elife.34077.071 |
0.314 |
|
| 2017 |
Lodato NJ, Melia T, Rampersaud A, Waxman DJ. Sex-Differential Responses of Tumor Promotion-Associated Genes and Dysregulation of Novel Long Noncoding RNAs in Constitutive Androstane Receptor-Activated Mouse Liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 25-41. PMID 28903501 DOI: 10.1093/Toxsci/Kfx114 |
0.417 |
|
| 2017 |
Lau-Corona D, Suvorov A, Waxman DJ. Feminization of male mouse liver by persistent growth hormone stimulation: Activation of sex-biased transcriptional networks and dynamic changes in chromatin states. Molecular and Cellular Biology. PMID 28694329 DOI: 10.1128/Mcb.00301-17 |
0.36 |
|
| 2017 |
Connerney J, Lau-Corona D, Rampersaud A, Waxman DJ. Activation of Male Liver Chromatin Accessibility and STAT5-dependent Gene Transcription by Plasma Growth Hormone Pulses. Endocrinology. PMID 28323953 DOI: 10.1210/En.2017-00060 |
0.382 |
|
| 2016 |
Wu J, Jordan M, Waxman DJ. Metronomic cyclophosphamide activation of anti-tumor immunity: tumor model, mouse host, and drug schedule dependence of gene responses and their upstream regulators. Bmc Cancer. 16: 623. PMID 27515027 DOI: 10.1186/S12885-016-2597-2 |
0.378 |
|
| 2016 |
Haery L, Mussakhan S, Waxman DJ, Gilmore TD. Evidence for an oncogenic modifier role for mutant histone acetyltransferases in diffuse large B-cell lymphoma. Leukemia & Lymphoma. 1-11. PMID 27003102 DOI: 10.3109/10428194.2016.1160083 |
0.344 |
|
| 2016 |
Oshida K, Vasani N, Waxman DJ, Corton JC. Disruption of STAT5b-Regulated Sexual Dimorphism of the Liver Transcriptome by Diverse Factors Is a Common Event. Plos One. 11: e0148308. PMID 26959975 DOI: 10.1371/Journal.Pone.0148308 |
0.393 |
|
| 2016 |
Oshida K, Waxman DJ, Corton JC. Chemical and Hormonal Effects on STAT5b-Dependent Sexual Dimorphism of the Liver Transcriptome. Plos One. 11: e0150284. PMID 26959237 DOI: 10.1371/Journal.Pone.0150284 |
0.396 |
|
| 2016 |
Jordan M, Waxman DJ. Abstract B121: Low dose, metronomic cyclophosphamide therapy sensitizes tumors to CpG-1826 immunotherapy in a preclinical glioma model Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B121 |
0.382 |
|
| 2015 |
Jordan M, Waxman DJ. CpG-1826 immunotherapy potentiates anti-tumor and anti-tumor immune responses to metronomic cyclophosphamide in a preclinical glioma model. Cancer Letters. PMID 26655275 DOI: 10.1016/J.Canlet.2015.11.029 |
0.364 |
|
| 2015 |
Melia T, Hao P, Yilmaz F, Waxman DJ. Hepatic lincRNAs: high promoter conservation and dynamic, sex-dependent transcriptional regulation by growth hormone. Molecular and Cellular Biology. PMID 26459762 DOI: 10.1128/Mcb.00861-15 |
0.368 |
|
| 2015 |
Conforto TL, Steinhardt GF, Waxman DJ. Cross Talk Between GH-Regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver. Molecular Endocrinology (Baltimore, Md.). 29: 1286-302. PMID 26218442 DOI: 10.1210/Me.2015-1028 |
0.36 |
|
| 2015 |
Wu J, Waxman DJ. Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8(+) T-cell responses and immune memory. Oncoimmunology. 4: e1005521. PMID 26137402 DOI: 10.1080/2162402X.2015.1005521 |
0.35 |
|
| 2015 |
Doloff JC, Waxman DJ. Transcriptional profiling provides insights into metronomic cyclophosphamide-activated, innate immune-dependent regression of brain tumor xenografts. Bmc Cancer. 15: 375. PMID 25952672 DOI: 10.1186/S12885-015-1358-Y |
0.665 |
|
| 2015 |
Kareva I, Waxman DJ, Lakka Klement G. Metronomic chemotherapy: an attractive alternative to maximum tolerated dose therapy that can activate anti-tumor immunity and minimize therapeutic resistance. Cancer Letters. 358: 100-6. PMID 25541061 DOI: 10.1016/J.Canlet.2014.12.039 |
0.365 |
|
| 2014 |
Wu J, Waxman DJ. Metronomic cyclophosphamide schedule-dependence of innate immune cell recruitment and tumor regression in an implanted glioma model. Cancer Letters. 353: 272-80. PMID 25069038 DOI: 10.1016/J.Canlet.2014.07.033 |
0.345 |
|
| 2014 |
Doloff JC, Chen CS, Waxman DJ. Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2. Molecular Cancer. 13: 158. PMID 24965046 DOI: 10.1186/1476-4598-13-158 |
0.672 |
|
| 2014 |
Chen CS, Doloff JC, Waxman DJ. Intermittent metronomic drug schedule is essential for activating antitumor innate immunity and tumor xenograft regression. Neoplasia (New York, N.Y.). 16: 84-96. PMID 24563621 DOI: 10.1593/Neo.131910 |
0.669 |
|
| 2014 |
Manley E, Waxman DJ. H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity. Cancer Letters. 346: 63-73. PMID 24334139 DOI: 10.1016/J.Canlet.2013.12.012 |
0.346 |
|
| 2014 |
Doloff JC, Waxman DJ. Adenoviral vectors for prodrug activation-based gene therapy for cancer. Anti-Cancer Agents in Medicinal Chemistry. 14: 115-26. PMID 23869779 DOI: 10.2174/18715206113139990309 |
0.682 |
|
| 2013 |
Sugathan A, Waxman DJ. Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver. Molecular and Cellular Biology. 33: 3594-610. PMID 23836885 DOI: 10.1128/Mcb.00280-13 |
0.331 |
|
| 2013 |
Yip KS, Suvorov A, Connerney J, Lodato NJ, Waxman DJ. Changes in mouse uterine transcriptome in estrus and proestrus. Biology of Reproduction. 89: 13. PMID 23740946 DOI: 10.1095/Biolreprod.112.107334 |
0.337 |
|
| 2013 |
Zhang K, Waxman DJ. Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model. Molecular Cancer Therapeutics. 12: 787-98. PMID 23635653 DOI: 10.1158/1535-7163.Mct-12-1240 |
0.339 |
|
| 2013 |
Jia L, Waxman DJ. Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis. Cancer Letters. 330: 241-9. PMID 23228633 DOI: 10.1016/J.Canlet.2012.11.055 |
0.355 |
|
| 2013 |
Manley E, Waxman DJ. Impact of tumor blood flow modulation on tumor sensitivity to the bioreductive drug banoxantrone. The Journal of Pharmacology and Experimental Therapeutics. 344: 368-77. PMID 23192656 DOI: 10.1124/Jpet.112.200089 |
0.379 |
|
| 2013 |
Waxman DJ, Chen C, Wu J, Doloff JC. Abstract A87: Metronomic chemotherapy activates innate immunity-induced tumor regression. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-A87 |
0.688 |
|
| 2012 |
Conforto TL, Zhang Y, Sherman J, Waxman DJ. Impact of CUX2 on the female mouse liver transcriptome: activation of female-biased genes and repression of male-biased genes. Molecular and Cellular Biology. 32: 4611-27. PMID 22966202 DOI: 10.1128/Mcb.00886-12 |
0.358 |
|
| 2012 |
Conforto TL, Waxman DJ. Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood. Biology of Sex Differences. 3: 9. PMID 22475005 DOI: 10.1186/2042-6410-3-9 |
0.338 |
|
| 2012 |
Doloff JC, Waxman DJ. VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression. Cancer Research. 72: 1103-15. PMID 22237627 DOI: 10.1158/0008-5472.Can-11-3380 |
0.686 |
|
| 2012 |
Zhang Y, Laz EV, Waxman DJ. Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Molecular and Cellular Biology. 32: 880-96. PMID 22158971 DOI: 10.1128/Mcb.06312-11 |
0.372 |
|
| 2012 |
Hecht JE, Schreiber Schwartz P, Waxman DJ. 8 tumor models for evaluation of p450 gene therapy in vivo. Methods in Molecular Medicine. 35: 107-18. PMID 21390803 DOI: 10.1385/1-59259-086-1:107 |
0.397 |
|
| 2012 |
D Hecht JE, Waxman DJ. 7 in vitro methods for evaluation of p450-based anticancer gene therapy. Methods in Molecular Medicine. 35: 95-105. PMID 21390802 DOI: 10.1385/1-59259-086-1:95 |
0.406 |
|
| 2012 |
Hecht JE, Jounaidi Y, Waxman DJ. Construction of p450-expressing tumor cell lines using retroviruses. Methods in Molecular Medicine. 35: 85-94. PMID 21390801 DOI: 10.1385/1-59259-086-1:85 |
0.403 |
|
| 2012 |
Hecht JE, Waxman DJ. Selection of cytochrome p450 genes for use in prodrug activation-based cancer gene therapy. Methods in Molecular Medicine. 35: 77-83. PMID 21390800 DOI: 10.1385/1-59259-086-1:77 |
0.39 |
|
| 2011 |
Zhang Y, Klein K, Sugathan A, Nassery N, Dombkowski A, Zanger UM, Waxman DJ. Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. Plos One. 6: e23506. PMID 21858147 DOI: 10.1371/Journal.Pone.0023506 |
0.353 |
|
| 2011 |
Bagchi G, Zhang Y, Stanley KA, Waxman DJ. Complex modulation of androgen responsive gene expression by methoxyacetic acid. Reproductive Biology and Endocrinology : Rb&E. 9: 42. PMID 21453523 DOI: 10.1186/1477-7827-9-42 |
0.352 |
|
| 2011 |
Ma J, Chen CS, Blute T, Waxman DJ. Antiangiogenesis enhances intratumoral drug retention. Cancer Research. 71: 2675-85. PMID 21447737 DOI: 10.1158/0008-5472.Can-10-3242 |
0.376 |
|
| 2011 |
Doloff JC, Jounaidi Y, Waxman DJ. Dual E1A oncolytic adenovirus: targeting tumor heterogeneity with two independent cancer-specific promoter elements, DF3/MUC1 and hTERT. Cancer Gene Therapy. 18: 153-66. PMID 20865021 DOI: 10.1038/Cgt.2010.52 |
0.688 |
|
| 2010 |
Zhang K, Waxman DJ. PC3 prostate tumor-initiating cells with molecular profile FAM65Bhigh/MFI2low/LEF1low increase tumor angiogenesis. Molecular Cancer. 9: 319. PMID 21190562 DOI: 10.1186/1476-4598-9-319 |
0.343 |
|
| 2010 |
Ling G, Sugathan A, Mazor T, Fraenkel E, Waxman DJ. Unbiased, genome-wide in vivo mapping of transcriptional regulatory elements reveals sex differences in chromatin structure associated with sex-specific liver gene expression. Molecular and Cellular Biology. 30: 5531-44. PMID 20876297 DOI: 10.1128/Mcb.00601-10 |
0.347 |
|
| 2010 |
Doloff JC, Su T, Waxman DJ. Adenoviral delivery of pan-caspase inhibitor p35 enhances bystander killing by P450 gene-directed enzyme prodrug therapy using cyclophosphamide+. Bmc Cancer. 10: 487. PMID 20836875 DOI: 10.1186/1471-2407-10-487 |
0.703 |
|
| 2010 |
Bagchi G, Zhang Y, Waxman DJ. Impact of methoxyacetic acid on mouse Leydig cell gene expression. Reproductive Biology and Endocrinology : Rb&E. 8: 65. PMID 20565877 DOI: 10.1186/1477-7827-8-65 |
0.335 |
|
| 2010 |
Tian N, Arany I, Waxman DJ, Baliga R. Cytochrome-P450 2B1 gene silencing attenuates puromycin aminonucleoside-induced cytotoxicity in glomerular epithelial cells. Kidney International. 78: 182-90. PMID 20407477 DOI: 10.1038/Ki.2010.100 |
0.336 |
|
| 2010 |
Swanson HI, Njar VC, Yu Z, Castro DJ, Gonzalez FJ, Williams DE, Huang Y, Kong AN, Doloff JC, Ma J, Waxman DJ, Scott EE. Targeting drug-metabolizing enzymes for effective chemoprevention and chemotherapy. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 539-44. PMID 20233842 DOI: 10.1124/Dmd.109.031351 |
0.693 |
|
| 2010 |
Wauthier V, Sugathan A, Meyer RD, Dombkowski AA, Waxman DJ. Intrinsic sex differences in the early growth hormone responsiveness of sex-specific genes in mouse liver. Molecular Endocrinology (Baltimore, Md.). 24: 667-78. PMID 20150183 DOI: 10.1210/Jcem.95.2.9993 |
0.387 |
|
| 2010 |
Doloff JC, Waxman DJ. Abstract 3813: Recruitment of macrophages, NK cells, and dendritic cells with metronomic cyclophosphamide-induced regression of gliosarcoma xenografts Cancer Research. 70: 3813-3813. DOI: 10.1158/1538-7445.Am10-3813 |
0.695 |
|
| 2010 |
Manley E, Waxman DJ. Abstract 1379: Impact of tumor blood flow modulation on sensitivity of 9L gliosarcoma xenografts to the bioreductive drug, AQ4N Cancer Research. 70: 1379-1379. DOI: 10.1158/1538-7445.Am10-1379 |
0.373 |
|
| 2009 |
Meyer RD, Laz EV, Su T, Waxman DJ. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Molecular Endocrinology (Baltimore, Md.). 23: 1914-26. PMID 19797429 DOI: 10.1210/Me.2009-0242 |
0.359 |
|
| 2009 |
Waxman DJ, Holloway MG. Sex differences in the expression of hepatic drug metabolizing enzymes. Molecular Pharmacology. 76: 215-28. PMID 19483103 DOI: 10.1124/Mol.109.056705 |
0.41 |
|
| 2009 |
Laz EV, Sugathan A, Waxman DJ. Dynamic in vivo binding of STAT5 to growth hormone-regulated genes in intact rat liver. Sex-specific binding at low- but not high-affinity STAT5 sites. Molecular Endocrinology (Baltimore, Md.). 23: 1242-54. PMID 19423653 DOI: 10.1210/Me.2008-0449 |
0.327 |
|
| 2009 |
Chin M, Herscovitch M, Zhang N, Waxman DJ, Gilmore TD. Overexpression of an activated REL mutant enhances the transformed state of the human B-lymphoma BJAB cell line and alters its gene expression profile. Oncogene. 28: 2100-11. PMID 19377508 DOI: 10.1038/Onc.2009.74 |
0.342 |
|
| 2009 |
Löfgren S, Baldwin RM, Carlerös M, Terelius Y, Fransson-Steen R, Mwinyi J, Waxman DJ, Ingelman-Sundberg M. Regulation of human CYP2C18 and CYP2C19 in transgenic mice: influence of castration, testosterone, and growth hormone. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1505-12. PMID 19339376 DOI: 10.1124/Dmd.109.026963 |
0.363 |
|
| 2009 |
Ma J, Waxman DJ. Dominant effect of antiangiogenesis in combination therapy involving cyclophosphamide and axitinib. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 578-88. PMID 19147763 DOI: 10.1158/1078-0432.Ccr-08-1174 |
0.323 |
|
| 2009 |
Lu H, Chen CS, Waxman DJ. Potentiation of methoxymorpholinyl doxorubicin antitumor activity by P450 3A4 gene transfer. Cancer Gene Therapy. 16: 393-404. PMID 19011599 DOI: 10.1038/Cgt.2008.93 |
0.451 |
|
| 2009 |
Bagchi G, Hurst CH, Waxman DJ. Interactions of methoxyacetic acid with androgen receptor. Toxicology and Applied Pharmacology. 238: 101-10. PMID 18486176 DOI: 10.1016/J.Taap.2008.03.015 |
0.334 |
|
| 2009 |
Doloff JC, Waxman DJ. Abstract A80: Metronomic cyclophosphamide induces macrophage recruitment in regressing human and rat gliosarcoma xenografts Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-A80 |
0.689 |
|
| 2008 |
Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Molecular Cancer Therapeutics. 7: 3670-84. PMID 19074844 DOI: 10.1158/1535-7163.Mct-08-0715 |
0.349 |
|
| 2008 |
Doloff JC, Waxman DJ, Jounaidi Y. Human telomerase reverse transcriptase promoter-driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions. Human Gene Therapy. 19: 1383-400. PMID 18771358 DOI: 10.1089/Hum.2008.056 |
0.682 |
|
| 2008 |
Johnston TP, Waxman DJ. The induction of atherogenic dyslipidaemia in poloxamer 407-treated mice is not mediated through PPARalpha. The Journal of Pharmacy and Pharmacology. 60: 753-9. PMID 18498712 DOI: 10.1211/Jpp.60.6.0011 |
0.356 |
|
| 2008 |
Wauthier V, Waxman DJ. Sex-specific early growth hormone response genes in rat liver. Molecular Endocrinology (Baltimore, Md.). 22: 1962-74. PMID 18483176 DOI: 10.1210/Me.2007-0549 |
0.372 |
|
| 2008 |
Holloway MG, Miles GD, Dombkowski AA, Waxman DJ. Liver-specific hepatocyte nuclear factor-4alpha deficiency: greater impact on gene expression in male than in female mouse liver. Molecular Endocrinology (Baltimore, Md.). 22: 1274-86. PMID 18276827 DOI: 10.1210/Me.2007-0564 |
0.382 |
|
| 2008 |
Ma J, Waxman DJ. Modulation of the antitumor activity of metronomic cyclophosphamide by the angiogenesis inhibitor axitinib. Molecular Cancer Therapeutics. 7: 79-89. PMID 18202011 DOI: 10.1158/1535-7163.Mct-07-0584 |
0.386 |
|
| 2008 |
Bagchi G, Waxman DJ. Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression. International Journal of Andrology. 31: 269-74. PMID 18179559 DOI: 10.1111/J.1365-2605.2007.00846.X |
0.329 |
|
| 2008 |
Doloff JC, Waxman DJ, Jounaidi Y. hTERT-promoter driven oncolytic adenovirus with E1B-19 kDa and E1B-55 kDa gene deletions Human Gene Therapy. 81015093227032. DOI: 10.1089/Hgt.2008.056 |
0.648 |
|
| 2007 |
Ma J, Waxman DJ. Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment. Molecular Cancer Therapeutics. 6: 2879-90. PMID 17989319 DOI: 10.1158/1535-7163.Mct-07-0297 |
0.441 |
|
| 2007 |
Chen CS, Jounaidi Y, Su T, Waxman DJ. Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model. Cancer Gene Therapy. 14: 935-44. PMID 17853921 DOI: 10.1038/Sj.Cgt.7701092 |
0.439 |
|
| 2007 |
Clodfelter KH, Miles GD, Wauthier V, Holloway MG, Zhang X, Hodor P, Ray WJ, Waxman DJ. Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis. Physiological Genomics. 31: 63-74. PMID 17536022 DOI: 10.1152/Physiolgenomics.00055.2007 |
0.373 |
|
| 2007 |
Jounaidi Y, Doloff JC, Waxman DJ. Conditionally replicating adenoviruses for cancer treatment. Current Cancer Drug Targets. 7: 285-301. PMID 17504125 DOI: 10.2174/156800907780618301 |
0.675 |
|
| 2007 |
Laz EV, Holloway MG, Chen CS, Waxman DJ. Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology. 148: 3327-37. PMID 17412818 DOI: 10.1210/En.2006-1192 |
0.386 |
|
| 2007 |
Holloway MG, Cui Y, Laz EV, Hosui A, Hennighausen L, Waxman DJ. Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus. Endocrinology. 148: 1977-86. PMID 17317776 DOI: 10.1210/En.2006-1419 |
0.372 |
|
| 2007 |
Gu J, Chen CS, Wei Y, Fang C, Xie F, Kannan K, Yang W, Waxman DJ, Ding X. A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition. The Journal of Pharmacology and Experimental Therapeutics. 321: 9-17. PMID 17218484 DOI: 10.1124/Jpet.106.118240 |
0.345 |
|
| 2006 |
Chang TK, Waxman DJ. Catalytic Assays for Human Cytochrome P450 : An Introduction. Methods in Molecular Biology (Clifton, N.J.). 320: 73-83. PMID 27699679 DOI: 10.1385/1-59259-998-2:73 |
0.348 |
|
| 2006 |
Crespi CL, Chang TK, Waxman DJ. High-Performance Liquid Chromatography Analysis of CYP2C8-Catalyzed Paclitaxel 6α-Hydroxylation. Methods in Molecular Biology (Clifton, N.J.). 320: 103-107. PMID 27699666 DOI: 10.1385/1-59259-998-2:103 |
0.326 |
|
| 2006 |
Clodfelter KH, Waxman DJ, Vajda S. Computational solvent mapping reveals the importance of local conformational changes for broad substrate specificity in mammalian cytochromes P450. Biochemistry. 45: 9393-407. PMID 16878974 DOI: 10.1021/Bi060343V |
0.311 |
|
| 2006 |
Waxman DJ, Chang TK. Use of 7-ethoxycoumarin to monitor multiple enzymes in the human CYP1, CYP2, and CYP3 families. Methods in Molecular Biology (Clifton, N.J.). 320: 153-6. PMID 16719387 DOI: 10.1385/1-59259-998-2:153 |
0.349 |
|
| 2006 |
Chang TK, Crespi CL, Waxman DJ. Determination of CYP2B6 component of 7-ethoxy-4-trifluoromethylcoumarin O-deethylation activity in human liver microsomes. Methods in Molecular Biology (Clifton, N.J.). 320: 97-102. PMID 16719378 DOI: 10.1385/1-59259-998-2:97 |
0.36 |
|
| 2006 |
Park SH, Wiwi CA, Waxman DJ. Signalling cross-talk between hepatocyte nuclear factor 4alpha and growth-hormone-activated STAT5b. The Biochemical Journal. 397: 159-68. PMID 16584384 DOI: 10.1042/Bj20060332 |
0.347 |
|
| 2006 |
Jounaidi Y, Chen CS, Veal GJ, Waxman DJ. Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11. Molecular Cancer Therapeutics. 5: 541-55. PMID 16546968 DOI: 10.1158/1535-7163.Mct-05-0321 |
0.406 |
|
| 2006 |
Günther M, Waxman DJ, Wagner E, Ogris M. Effects of hypoxia and limited diffusion in tumor cell microenvironment on bystander effect of P450 prodrug therapy. Cancer Gene Therapy. 13: 771-9. PMID 16543915 DOI: 10.1038/Sj.Cgt.7700955 |
0.412 |
|
| 2006 |
Waxman DJ, O'Connor C. Growth hormone regulation of sex-dependent liver gene expression. Molecular Endocrinology (Baltimore, Md.). 20: 2613-29. PMID 16543404 DOI: 10.1210/Me.2006-0007 |
0.4 |
|
| 2006 |
Clodfelter KH, Holloway MG, Hodor P, Park SH, Ray WJ, Waxman DJ. Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis. Molecular Endocrinology (Baltimore, Md.). 20: 1333-51. PMID 16469768 DOI: 10.1210/Me.2005-0489 |
0.363 |
|
| 2006 |
Roy P, Waxman DJ. Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 176-86. PMID 16293390 DOI: 10.1016/J.Tiv.2005.06.046 |
0.437 |
|
| 2006 |
Cheung C, Yu AM, Chen CS, Krausz KW, Byrd LG, Feigenbaum L, Edwards RJ, Waxman DJ, Gonzalez FJ. Growth hormone determines sexual dimorphism of hepatic cytochrome P450 3A4 expression in transgenic mice. The Journal of Pharmacology and Experimental Therapeutics. 316: 1328-34. PMID 16291874 DOI: 10.1124/Jpet.105.094367 |
0.391 |
|
| 2006 |
Shipley JM, Waxman DJ. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicology and Applied Pharmacology. 213: 87-97. PMID 16257430 DOI: 10.1016/J.Taap.2005.09.011 |
0.354 |
|
| 2006 |
Holloway MG, Laz EV, Waxman DJ. Codependence of growth hormone-responsive, sexually dimorphic hepatic gene expression on signal transducer and activator of transcription 5b and hepatic nuclear factor 4alpha. Molecular Endocrinology (Baltimore, Md.). 20: 647-60. PMID 16239260 DOI: 10.1210/Me.2005-0328 |
0.352 |
|
| 2005 |
Chang TK, Waxman DJ. Pregnane X receptor-mediated transcription. Methods in Enzymology. 400: 588-98. PMID 16399372 DOI: 10.1016/S0076-6879(05)00033-9 |
0.361 |
|
| 2005 |
Riddick DS, Lee C, Ramji S, Chinje EC, Cowen RL, Williams KJ, Patterson AV, Stratford IJ, Morrow CS, Townsend AJ, Jounaidi Y, Chen CS, Su T, Lu H, Schwartz PS, ... Waxman DJ, et al. Cancer chemotherapy and drug metabolism. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1083-96. PMID 16049130 DOI: 10.1124/Dmd.105.004374 |
0.327 |
|
| 2005 |
Chen CS, Jounaidi Y, Waxman DJ. Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1261-7. PMID 15919850 DOI: 10.1124/Dmd.105.004788 |
0.379 |
|
| 2005 |
Kumar S, Chen CS, Waxman DJ, Halpert JR. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide. The Journal of Biological Chemistry. 280: 19569-75. PMID 15774478 DOI: 10.1074/Jbc.M500158200 |
0.321 |
|
| 2005 |
Wiwi CA, Waxman DJ. Role of hepatocyte nuclear factors in transcriptional regulation of male-specific CYP2A2. The Journal of Biological Chemistry. 280: 3259-68. PMID 15539409 DOI: 10.1074/Jbc.M409294200 |
0.415 |
|
| 2005 |
Lu H, Waxman DJ. Antitumor activity of methoxymorpholinyl doxorubicin: potentiation by cytochrome P450 3A metabolism. Molecular Pharmacology. 67: 212-9. PMID 15465924 DOI: 10.1124/Mol.104.005371 |
0.442 |
|
| 2004 |
Laz EV, Wiwi CA, Waxman DJ. Sexual dimorphism of rat liver nuclear proteins: regulatory role of growth hormone. Molecular & Cellular Proteomics : McP. 3: 1170-80. PMID 15456855 DOI: 10.1074/Mcp.M400102-Mcp200 |
0.34 |
|
| 2004 |
Shipley JM, Waxman DJ. Simultaneous, bidirectional inhibitory crosstalk between PPAR and STAT5b. Toxicology and Applied Pharmacology. 199: 275-84. PMID 15364543 DOI: 10.1016/J.Taap.2003.12.020 |
0.383 |
|
| 2004 |
Hurst CH, Waxman DJ. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicology and Applied Pharmacology. 199: 266-74. PMID 15364542 DOI: 10.1016/J.Taap.2003.11.028 |
0.35 |
|
| 2004 |
Schlezinger JJ, Howard GJ, Hurst CH, Emberley JK, Waxman DJ, Webster T, Sherr DH. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-deoxy-Delta12,14-prostaglandin J2. Journal of Immunology (Baltimore, Md. : 1950). 173: 3165-77. PMID 15322177 DOI: 10.4049/Jimmunol.173.5.3165 |
0.306 |
|
| 2004 |
Wiwi CA, Waxman DJ. Role of hepatocyte nuclear factors in growth hormone-regulated, sexually dimorphic expression of liver cytochromes P450. Growth Factors (Chur, Switzerland). 22: 79-88. PMID 15253383 DOI: 10.1080/08977190410001715172 |
0.386 |
|
| 2004 |
Wiwi CA, Gupte M, Waxman DJ. Sexually dimorphic P450 gene expression in liver-specific hepatocyte nuclear factor 4alpha-deficient mice. Molecular Endocrinology (Baltimore, Md.). 18: 1975-87. PMID 15155787 DOI: 10.1210/Me.2004-0129 |
0.386 |
|
| 2004 |
Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics. Molecular Pharmacology. 65: 1278-85. PMID 15102956 DOI: 10.1124/Mol.65.5.1278 |
0.314 |
|
| 2004 |
Shipley JM, Hurst CH, Tanaka SS, DeRoos FL, Butenhoff JL, Seacat AM, Waxman DJ. trans-activation of PPARalpha and induction of PPARalpha target genes by perfluorooctane-based chemicals. Toxicological Sciences : An Official Journal of the Society of Toxicology. 80: 151-60. PMID 15071170 DOI: 10.1093/Toxsci/Kfh130 |
0.396 |
|
| 2004 |
Su T, Waxman DJ. Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes Archives of Biochemistry and Biophysics. 424: 226-234. PMID 15047195 DOI: 10.1016/J.Abb.2004.02.008 |
0.372 |
|
| 2004 |
Jounaidi Y, Waxman DJ. Use of Replication-Conditional Adenovirus as a Helper System to Enhance Delivery of P450 Prodrug-Activation Genes for Cancer Therapy Cancer Research. 64: 292-303. PMID 14729637 DOI: 10.1158/0008-5472.Can-03-1798 |
0.43 |
|
| 2004 |
Ahluwalia A, Clodfelter KH, Waxman DJ. Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. Molecular Endocrinology (Baltimore, Md.). 18: 747-60. PMID 14684848 DOI: 10.1210/Me.2003-0138 |
0.374 |
|
| 2004 |
Chiocca EA, Waxman DJ. Cytochrome p450-based gene therapies for cancer Methods in Molecular Medicine. 90: 203-222. PMID 14657565 DOI: 10.1385/1-59259-429-8:203 |
0.314 |
|
| 2003 |
Waxman DJ, Celenza JL. Sexual dimorphism of hepatic gene expression: novel biological role of KRAB zinc finger repressors revealed. Genes & Development. 17: 2607-13. PMID 14597659 DOI: 10.1101/Gad.1154603 |
0.348 |
|
| 2003 |
Chang TK, Crespi CL, Waxman DJ. Spectrophotometric analysis of human CYP2E1-catalyzed p-nitrophenol hydroxylation. Methods in Molecular Biology (Clifton, N.J.). 107: 147-52. PMID 14577224 DOI: 10.1385/0-89603-519-0:147 |
0.343 |
|
| 2003 |
Schwartz PS, Chen CS, Waxman DJ. Sustained P450 expression and prodrug activation in bolus cyclophosphamide-treated cultured tumor cells. Impact of prodrug schedule on P450 gene-directed enzyme prodrug therapy Cancer Gene Therapy. 10: 571-582. PMID 12872138 DOI: 10.1038/Sj.Cgt.7700601 |
0.441 |
|
| 2003 |
Shipley JM, Waxman DJ. Down-regulation of STAT5b transcriptional activity by ligand-activated peroxisome proliferator-activated receptor (PPAR) α and PPARγ Molecular Pharmacology. 64: 355-364. PMID 12869640 DOI: 10.1124/Mol.64.2.355 |
0.357 |
|
| 2003 |
Hurst CH, Waxman DJ. Activation of PPARα and PPARγ by environmental phthalate monoesters Toxicological Sciences. 74: 297-308. PMID 12805656 DOI: 10.1093/Toxsci/Kfg145 |
0.377 |
|
| 2003 |
Baldwin A, Huang Z, Jounaidi Y, Waxman DJ. Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer Archives of Biochemistry and Biophysics. 409: 197-206. PMID 12464259 DOI: 10.1016/S0003-9861(02)00453-8 |
0.447 |
|
| 2003 |
Apletalina EV, Li HC, Waxman DJ. Evaluation of thyroid hormone effects on liver P450 reductase translation Archives of Biochemistry and Biophysics. 409: 172-179. PMID 12464256 DOI: 10.1016/S0003-9861(02)00417-4 |
0.316 |
|
| 2002 |
Schwartz PS, Chen CS, Waxman DJ. Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35 Cancer Research. 62: 6928-6937. PMID 12460909 |
0.33 |
|
| 2002 |
Zhou YC, Davey HW, McLachlan MJ, Xie T, Waxman DJ. Elevated basal expression of liver peroxisomal beta-oxidation enzymes and CYP4A microsomal fatty acid omega-hydroxylase in STAT5b(-/-) mice: cross-talk in vivo between peroxisome proliferator-activated receptor and signal transducer and activator of transcription signaling pathways. Toxicology and Applied Pharmacology. 182: 1-10. PMID 12127257 DOI: 10.1006/Taap.2002.9426 |
0.415 |
|
| 2002 |
Chen L, Waxman DJ. Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer Current Pharmaceutical Design. 8: 1405-1416. PMID 12052216 DOI: 10.2174/1381612023394566 |
0.442 |
|
| 2002 |
Tzanakakis ES, Waxman DJ, Hansen LK, Remmel RP, Hu WS. Long-term enhancement of cytochrome P450 2B1/2 expression in rat hepatocyte spheroids through adenovirus-mediated gene transfer. Cell Biology and Toxicology. 18: 13-27. PMID 11991083 DOI: 10.1023/A:1014415128392 |
0.367 |
|
| 2001 |
Park SH, Yamashita H, Rui H, Waxman DJ. Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: Impact on STAT5 transcriptional activity Molecular Endocrinology. 15: 2157-2171. PMID 11731617 DOI: 10.1210/Mend.15.12.0746 |
0.336 |
|
| 2001 |
Schwartz PS, Waxman DJ. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells Molecular Pharmacology. 60: 1268-1279. PMID 11723234 DOI: 10.1124/Mol.60.6.1268 |
0.369 |
|
| 2001 |
Tannenbaum GS, Choi HK, Gurd W, Waxman DJ. Temporal relationship between the sexually dimorphic spontaneous GH secretory profiles and hepatic STAT5 activity. Endocrinology. 142: 4599-606. PMID 11606424 DOI: 10.1210/Endo.142.11.8480 |
0.362 |
|
| 2001 |
Park SH, Waxman DJ. Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3β: Impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression Journal of Biological Chemistry. 276: 43031-43039. PMID 11562369 DOI: 10.1074/Jbc.M107597200 |
0.419 |
|
| 2001 |
Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR. STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology. 142: 3836-41. PMID 11517160 DOI: 10.1210/Endo.142.9.8400 |
0.374 |
|
| 2001 |
Huang Z, Waxman DJ. Modulation of cyclophosphamide-based cytochrome P450 gene therapy using liver P450 inhibitors Cancer Gene Therapy. 8: 450-458. PMID 11498765 DOI: 10.1038/Sj.Cgt.7700325 |
0.443 |
|
| 2001 |
Jounaidi Y, Waxman DJ. Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy Cancer Research. 61: 4437-4444. PMID 11389073 |
0.31 |
|
| 2001 |
Xie W, Radominska-Pandya A, Shi Y, Simon CM, Nelson MC, Ong ES, Waxman DJ, Evans RM. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids. Proceedings of the National Academy of Sciences of the United States of America. 98: 3375-80. PMID 11248086 DOI: 10.1073/Pnas.051014398 |
0.303 |
|
| 2000 |
Choi HK, Waxman DJ. Pulsatility of growth hormone (GH) signalling in liver cells: Role of the JAK-STAT5b pathway in GH action Growth Hormone and Igf Research. 10: S1-S8. PMID 10984246 DOI: 10.1016/S1096-6374(00)80002-7 |
0.364 |
|
| 2000 |
Choi HK, Waxman DJ. Plasma growth hormone pulse activation of hepatic JAK-STAT5 signaling: Developmental regulation and role in male-specific liver gene expression Endocrinology. 141: 3245-3255. PMID 10965895 DOI: 10.1210/Endo.141.9.7638 |
0.377 |
|
| 2000 |
Delesque-Touchard N, Park SH, Waxman DJ. Synergistic action of hepatocyte nuclear factors 3 and 6 on CYP2C12 gene expression and suppression by growth hormone-activated STAT5b. Proposed model for female-specific expression of CYP2C12 in adult rat liver Journal of Biological Chemistry. 275: 34173-34182. PMID 10931833 DOI: 10.1074/Jbc.M004027200 |
0.408 |
|
| 2000 |
Jounaidi Y, Waxman DJ. Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based cancer gene therapy Cancer Research. 60: 3761-3769. PMID 10919648 |
0.303 |
|
| 2000 |
Huang Z, Raychowdhury MK, Waxman DJ. Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450- based cancer gene therapy model Cancer Gene Therapy. 7: 1034-1042. PMID 10917206 DOI: 10.1038/Sj.Cgt.7700200 |
0.446 |
|
| 2000 |
Waxman DJ. Growth hormone pulse-activated STAT5 signalling: A unique regulatory mechanism governing sexual dimorphism of liver gene expression Novartis Foundation Symposium. 227: 61-81. PMID 10752065 DOI: 10.1002/0470870796.Ch5 |
0.377 |
|
| 2000 |
Huang Z, Roy P, Waxman DJ. Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N- dechloroethylation of cyclophosphamide and ifosfamide Biochemical Pharmacology. 59: 961-972. PMID 10692561 DOI: 10.1016/S0006-2952(99)00410-4 |
0.356 |
|
| 1999 |
Davey HW, Park SH, Grattan DR, McLachlan MJ, Waxman DJ. STAT5b-deficient mice are growth hormone pulse-resistant. Role of STAT5b in sex-specific liver p450 expression. The Journal of Biological Chemistry. 274: 35331-6. PMID 10585399 DOI: 10.1074/Jbc.274.50.35331 |
0.345 |
|
| 1999 |
Maloney EK, Waxman DJ. trans-Activation of PPARα and PPARγ by structurally diverse environmental chemicals Toxicology and Applied Pharmacology. 161: 209-218. PMID 10581215 DOI: 10.1006/Taap.1999.8809 |
0.346 |
|
| 1999 |
Choi HK, Waxman DJ. Growth hormone, but not prolactin, maintains low-level activation of STAT5a and STAT5b in female rat liver Endocrinology. 140: 5126-5135. PMID 10537141 DOI: 10.1210/Endo.140.11.7106 |
0.375 |
|
| 1999 |
Zhou YC, Waxman DJ. STAT5b down-regulates peroxisome proliferator-activated receptor α transcription by inhibition of ligand-independent activation function region- 1 trans-activation domain Journal of Biological Chemistry. 274: 29874-29882. PMID 10514468 DOI: 10.1074/Jbc.274.42.29874 |
0.327 |
|
| 1999 |
Davey HW, Wilkins RJ, Waxman DJ. STAT5 signaling in sexually dimorphic gene expression and growth patterns American Journal of Human Genetics. 65: 959-965. PMID 10486314 DOI: 10.1086/302599 |
0.311 |
|
| 1999 |
Waxman DJ. P450 gene induction by structurally diverse xenochemicals: Central role of nuclear receptors CAR, PXR, and PPAR Archives of Biochemistry and Biophysics. 369: 11-23. PMID 10462436 DOI: 10.1006/Abbi.1999.1351 |
0.37 |
|
| 1999 |
Waxman DJ, Chen L, Hecht JED, Jounaidi Y. Cytochrome P450-based cancer gene therapy: Recent advances and future prospects Drug Metabolism Reviews. 31: 503-522. PMID 10335450 DOI: 10.1081/Dmr-100101933 |
0.448 |
|
| 1999 |
Park SH, Liu X, Hennighausen L, Davey HW, Waxman DJ. Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression: Impact of Stat5a gene disruption Journal of Biological Chemistry. 274: 7421-7430. PMID 10066807 DOI: 10.1074/Jbc.274.11.7421 |
0.396 |
|
| 1999 |
Gebert CA, Park SH, Waxman DJ. Down-regulation of liver JAK2-STAT5b signaling by the female plasma pattern of continuous growth hormone stimulation Molecular Endocrinology. 13: 213-227. PMID 9973252 DOI: 10.1210/Mend.13.2.0238 |
0.366 |
|
| 1999 |
Zhou YC, Waxman DJ. Cross-talk between Janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-α (PPARα) signaling pathways: Growth hormone inhibition of PPARα transcriptional activity mediated by STAT5b Journal of Biological Chemistry. 274: 2672-2681. PMID 9915797 DOI: 10.1074/Jbc.274.5.2672 |
0.346 |
|
| 1999 |
Gebert CA, Park SH, Waxman DJ. Termination of growth hormone pulse-induced STAT5b signaling Molecular Endocrinology. 13: 38-56. PMID 9892011 DOI: 10.1210/Mend.13.1.0235 |
0.326 |
|
| 1998 |
Waxman DJ, Chang TK. Thin-layer chromatographic analysis of human CYP3A-catalyzed testosterone 6 beta-hydroxylation Methods in Molecular Biology (Clifton, N.J.). 107: 153-161. PMID 14577225 DOI: 10.1385/0-89603-519-0:153 |
0.335 |
|
| 1998 |
Waxman DJ, Chang TK. Spectrofluorometric analysis of CYP2A6-catalyzed coumarin 7-hydroxylation Methods in Molecular Biology (Clifton, N.J.). 107: 111-116. PMID 14577218 DOI: 10.1385/0-89603-519-0:111 |
0.329 |
|
| 1998 |
Chang TK, Waxman DJ. Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate Methods in Molecular Biology (Clifton, N.J.). 107: 103-109. PMID 14577217 DOI: 10.1385/0-89603-519-0:103 |
0.339 |
|
| 1998 |
Jounaidi Y, Hecht JED, Waxman DJ. Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine- based cancer gene therapy Cancer Research. 58: 4391-4401. PMID 9766669 |
0.337 |
|
| 1998 |
Zhou YC, Waxman DJ. Activation of peroxisome proliferator-activated receptors by chlorinated hydrocarbons and endogenous steroids Environmental Health Perspectives. 106: 983-988. PMID 9703482 DOI: 10.1289/Ehp.98106S4983 |
0.376 |
|
| 1997 |
Chen L, Yu LJ, Waxman DJ. Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene Cancer Research. 57: 4830-4837. PMID 9354446 |
0.335 |
|
| 1997 |
Chang TKH, Yu L, Goldstein JA, Waxman DJ. Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-Ile359 allele as low-K(m) catalysts of cyclophosphamide and ifosfamide activation Pharmacogenetics. 7: 211-221. PMID 9241661 DOI: 10.1097/00008571-199706000-00006 |
0.332 |
|
| 1997 |
O'Leary KA, Li HC, Ram PA, McQuiddy P, Waxman DJ, Kasper CB. Thyroid regulation of NADPH:cytochrome P450 oxidoreductase: identification of a thyroid-responsive element in the 5'-flank of the oxidoreductase gene. Molecular Pharmacology. 52: 46-53. PMID 9224811 DOI: 10.1124/Mol.52.1.46 |
0.332 |
|
| 1997 |
Ram PA, Waxman DJ. Interaction of growth hormone-activated STATs with SH2-containing phosphotyrosine phosphatase SHP-1 and nuclear JAK2 tyrosine kinase Journal of Biological Chemistry. 272: 17694-17702. PMID 9211920 DOI: 10.1074/Jbc.272.28.17694 |
0.367 |
|
| 1997 |
Udy GB, Towers RP, Snell RG, Wilkins RJ, Park SH, Ram PA, Waxman DJ, Davey HW. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression Proceedings of the National Academy of Sciences of the United States of America. 94: 7239-7244. PMID 9207075 DOI: 10.1073/Pnas.94.14.7239 |
0.366 |
|
| 1997 |
Gebert CA, Park SH, Waxman DJ. Regulation of signal transducer and activator of transcription (STAT) 5b activation by the temporal pattern of growth hormone stimulation Molecular Endocrinology. 11: 400-414. PMID 9092792 DOI: 10.1210/Mend.11.4.9904 |
0.383 |
|
| 1996 |
Waxman DJ. Role of metabolism in the activation of dehydroepiandrosterone as a peroxisome proliferator Journal of Endocrinology. 150: S129-S147. PMID 8943797 DOI: 10.1677/Joe.0.150S129 |
0.382 |
|
| 1996 |
Waxman DJ, Zhao S, Choi HK. Interaction of a novel sex-dependent, growth hormone-regulated liver nuclear factor with CYP2C12 promoter Journal of Biological Chemistry. 271: 29978-29987. PMID 8939943 DOI: 10.1074/Jbc.271.47.29978 |
0.392 |
|
| 1996 |
Nelson DR, Koymans L, Kamataki T, Stegeman JJ, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Estabrook RW, Gunsalus IC, Nebert DW. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6: 1-42. PMID 8845856 DOI: 10.1097/00008571-199602000-00002 |
0.303 |
|
| 1996 |
Chen L, Waxman DJ, Chen D, Kufe DW. Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene Cancer Research. 56: 1331-1340. PMID 8640822 |
0.349 |
|
| 1996 |
Ram PA, Park SH, Choi HK, Waxman DJ. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver: Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation Journal of Biological Chemistry. 271: 5929-5940. PMID 8621467 DOI: 10.1074/Jbc.271.10.5929 |
0.38 |
|
| 1995 |
Chen G, Waxman DJ. Identification of glutathione S-transferase as a determinant of 4-hydroperoxycyclophosphamide resistance in human breast cancer cells Biochemical Pharmacology. 49: 1691-1701. PMID 7786310 DOI: 10.1016/0006-2952(95)00079-F |
0.34 |
|
| 1995 |
Waxman DJ, Ram PA, Park SH, Choi HK. Intermittent plasma growth hormone triggers tyrosine phosphorylation and nuclear translocation of a liver-expressed, Stat 5-related DNA binding protein. Proposed role as an intracellular regulator of male-specific liver gene transcription. The Journal of Biological Chemistry. 270: 13262-70. PMID 7768925 DOI: 10.1074/Jbc.270.22.13262 |
0.394 |
|
| 1995 |
Rifkind AB, Lee C, Chang TK, Waxman DJ. Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes. Archives of Biochemistry and Biophysics. 320: 380-9. PMID 7625847 DOI: 10.1016/0003-9861(95)90023-3 |
0.355 |
|
| 1994 |
Chen G, Waxman DJ. Role of cellular glutathione and glutathione S-transferase in the expression of alkylating agent cytotoxicity in human breast cancer cells. Biochemical Pharmacology. 47: 1079-87. PMID 8147907 DOI: 10.1016/0006-2952(94)90420-0 |
0.388 |
|
| 1994 |
Jean A, Reiss A, Desrochers M, Dubois S, Trottier E, Trottier Y, Wirtanen L, Adesnik M, Waxman DJ, Anderson A. Rat liver cytochrome P450 2B3: structure of the CYP2B3 gene and immunological identification of a constitutive P450 2B3-like protein in rat liver. Dna and Cell Biology. 13: 781-92. PMID 8068203 DOI: 10.1089/Dna.1994.13.781 |
0.347 |
|
| 1994 |
Ram PA, Waxman DJ. Dehydroepiandrosterone 3β-sulphate is an endogenous activator of the peroxisome-proliferation pathway: Induction of cytochrome P-450 4A and acyl-CoA oxidase mRNAs in primary rat hepatocyte culture and inhibitory effects of Ca2+-channel blockers Biochemical Journal. 301: 753-758. PMID 8053899 DOI: 10.1042/Bj3010753 |
0.305 |
|
| 1994 |
Shapiro BH, Pampori NA, Lapenson DP, Waxman DJ. Growth hormone-dependent and -independent sexually dimorphic regulation of phenobarbital-induced hepatic cytochromes P450 2B1 and 2B2. Archives of Biochemistry and Biophysics. 312: 234-9. PMID 8031133 DOI: 10.1006/Abbi.1994.1304 |
0.334 |
|
| 1994 |
Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TK, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Human Gene Therapy. 5: 969-78. PMID 7948146 DOI: 10.1089/Hum.1994.5.8-969 |
0.429 |
|
| 1994 |
Nanji AA, Zhao S, Sadrzadeh SMH, Waxman DJ. Use of reverse transcription–polymerase chain reaction to evaluatein vivo cytokine gene expression in rats fed ethanol for long periods Hepatology. 19: 1483-1487. DOI: 10.1002/Hep.1840190625 |
0.308 |
|
| 1993 |
Weber GF, Waxman DJ. Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes Biochemical Pharmacology. 45: 1685-1694. PMID 8484807 DOI: 10.1016/0006-2952(93)90310-S |
0.411 |
|
| 1993 |
Chang TK, Teixeira J, Gil G, Waxman DJ. The lithocholic acid 6 beta-hydroxylase cytochrome P-450, CYP 3A10, is an active catalyst of steroid-hormone 6 beta-hydroxylation. The Biochemical Journal. 429-33. PMID 8484723 DOI: 10.1042/Bj2910429 |
0.326 |
|
| 1993 |
Srivastava PK, Waxman DJ. Sex-dependent expression and growth hormone regulation of class alpha and class mu glutathione S-transferase mRNAs in adult rat liver. The Biochemical Journal. 159-65. PMID 8363567 DOI: 10.1042/Bj2940159 |
0.337 |
|
| 1993 |
Nanji AA, Zhao S, Lamb RG, Sadrzadeh SM, Dannenberg AJ, Waxman DJ. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: relationship to cytochrome P-450 2E1 induction and conjugated diene formation. Alcoholism, Clinical and Experimental Research. 17: 598-603. PMID 8333590 DOI: 10.1111/J.1530-0277.1993.Tb00806.X |
0.308 |
|
| 1993 |
Weber GF, Waxman DJ. Denitrosation of the anti-cancer drug 1,3-bis(2-chloroethyl)-1-nitrosourea catalyzed by microsomal glutathione S-transferase and cytochrome P450 monooxygenases Archives of Biochemistry and Biophysics. 307: 369-378. PMID 8274024 DOI: 10.1006/Abbi.1993.1602 |
0.396 |
|
| 1993 |
Nelson DR, Kamataki T, Waxman DJ, Guengerich FP, Estabrook RW, Feyereisen R, Gonzalez FJ, Coon MJ, Gunsalus IC, Gotoh O. The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. Dna and Cell Biology. 12: 1-51. PMID 7678494 DOI: 10.1089/Dna.1993.12.1 |
0.324 |
|
| 1992 |
Waxman DJ. Regulation of liver-specific steroid metabolizing cytochromes P450: Cholesterol 7α-hydroxylase, bile acid 6β-hydroxylase, and growth hormone-responsive steroid hormone hydroxylases Journal of Steroid Biochemistry and Molecular Biology. 43: 1055-1072. PMID 22217850 DOI: 10.1016/0960-0760(92)90333-E |
0.375 |
|
| 1992 |
Koch JA, Waxman DJ. P450 phosphorylation in isolated hepatocytes and in vivo. Methods in Enzymology. 206: 305-15. PMID 1664478 DOI: 10.1016/0076-6879(91)06100-H |
0.344 |
|
| 1992 |
Park SS, Walker W, Aoyama T, Lapenson DP, Waxman DJ, Gonzalez FJ, Gelboin HV. Monoclonal antibodies to rat liver microsomal cytochrome b5 Biochemical Pharmacology. 43: 2201-2208. PMID 1599506 DOI: 10.1016/0006-2952(92)90179-M |
0.329 |
|
| 1992 |
Correia MA, Yao K, Wrighton SA, Waxman DJ, Rettie AE. Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms? Archives of Biochemistry and Biophysics. 294: 493-503. PMID 1567205 DOI: 10.1016/0003-9861(92)90716-A |
0.308 |
|
| 1992 |
Waxman DJ, Azaroff L. Phenobarbital induction of cytochrome P-450 gene expression Biochemical Journal. 281: 577-592. PMID 1536639 DOI: 10.1042/Bj2810577 |
0.346 |
|
| 1991 |
Pampori NA, Agrawal AK, Waxman DJ, Shapiro BH. Differential effects of neonatally administered glutamate on the ultradian pattern of circulating growth hormone regulating expression of sex-dependent forms of cytochrome P450. Biochemical Pharmacology. 41: 1299-309. PMID 2018562 DOI: 10.1016/0006-2952(91)90101-A |
0.379 |
|
| 1991 |
Zimniak P, Holsztynska EJ, Radominska A, Iscan M, Lester R, Waxman DJ. Distinct forms of cytochrome P-450 are responsible for 6 beta-hydroxylation of bile acids and of neutral steroids. The Biochemical Journal. 105-11. PMID 2018466 DOI: 10.1042/Bj2750105 |
0.339 |
|
| 1991 |
Ram PA, Waxman DJ. Hepatic P450 expression in hypothyroid rats: Differential responsiveness of male-specific P450 forms 2a (IIIA2), 2c (IIC11), and RLM2 (IIA2) to thyroid hormone Molecular Endocrinology. 5: 13-20. PMID 2017188 DOI: 10.1210/Mend-5-1-13 |
0.342 |
|
| 1991 |
Waxman DJ, Lapenson DP, Aoyama T, Gelboin HV, Gonzalez FJ, Korzekwa K. Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Archives of Biochemistry and Biophysics. 290: 160-6. PMID 1898086 DOI: 10.1016/0003-9861(91)90602-F |
0.375 |
|
| 1991 |
Waxman DJ, Pampori NA, Ram PA, Agrawal AK, Shapiro BH. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proceedings of the National Academy of Sciences of the United States of America. 88: 6868-72. PMID 1862110 DOI: 10.1073/Pnas.88.15.6868 |
0.349 |
|
| 1991 |
Jauregui HO, Ng SF, Gann KL, Waxman DJ. Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 21: 1091-106. PMID 1788977 DOI: 10.3109/00498259109039549 |
0.343 |
|
| 1991 |
Waxman DJ. P450-catalyzed steroid hydroxylation: Assay and product identification by thin-layer chromatography Methods in Enzymology. 206: 462-476. PMID 1784231 DOI: 10.1016/0076-6879(91)06115-J |
0.36 |
|
| 1991 |
Waxman DJ. Rat hepatic P450IIA and P450IIC subfamily expression using catalytic, immunochemical, and molecular probes Methods in Enzymology. 206: 249-267. PMID 1784212 DOI: 10.1016/0076-6879(91)06095-K |
0.388 |
|
| 1990 |
Shapiro BH, MacLeod JN, Pampori NA, Morrissey JJ, Lapenson DP, Waxman DJ. Signalling elements in the ultradian rhythm of circulating growth hormone regulating expression of sex-dependent forms of hepatic cytochrome P450. Endocrinology. 125: 2935-44. PMID 2510988 DOI: 10.1210/Endo-125-6-2935 |
0.389 |
|
| 1990 |
Waxman DJ, Ram PA, Notani G, LeBlanc GA, Alberta JA, Morrissey JJ, Sundseth SS. Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level Molecular Endocrinology. 4: 447-454. PMID 2342479 DOI: 10.1210/Mend-4-3-447 |
0.386 |
|
| 1990 |
Waxman DJ, Lapenson DP, Nagata K, Conlon HD. Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation. The Biochemical Journal. 265: 187-94. PMID 2302165 DOI: 10.1042/Bj2650187 |
0.352 |
|
| 1990 |
Waxman DJ, Morrissey JJ, MacLeod JN, Shapiro BH. Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5 alpha-reductase. Endocrinology. 126: 712-20. PMID 2298167 DOI: 10.1210/Endo-126-2-712 |
0.396 |
|
| 1990 |
Waxman DJ, Morrissey JJ, Naik S, Jauregui HO. Phenobarbital induction of cytochromes P-450. High-level long-term responsiveness of primary rat hepatocyte cultures to drug induction, and glucocorticoid dependence of the phenobarbital response. The Biochemical Journal. 271: 113-9. PMID 2222405 DOI: 10.1042/Bj2710113 |
0.388 |
|
| 1990 |
Janeczko R, Waxman DJ, Le Blanc GA, Morville A, Adesnik M. Hormonal regulation of levels of the messenger RNA encoding hepatic P450 2c (IIC11), a constitutive male-specific form of cytochrome P450. Molecular Endocrinology (Baltimore, Md.). 4: 295-303. PMID 1691818 DOI: 10.1210/Mend-4-2-295 |
0.355 |
|
| 1989 |
Waxman DJ, Lapenson DP, Morrissey JJ, Park SS, Gelboin HV, Doehmer J, Oesch F. Androgen hydroxylation catalysed by a cell line (SD1) that stably expresses rat hepatic cytochrome P-450 PB-4 (IIB1) Biochemical Journal. 260: 81-85. PMID 2789039 DOI: 10.1042/Bj2600081 |
0.394 |
|
| 1989 |
Waxman DJ, Morrissey JJ, LeBlanc GA. Female-predominant rat hepatic P-450 forms j (IIE1) and 3 (IIA1) are under hormonal regulatory controls distinct from those of the sex-specific P-450 forms Endocrinology. 124: 2954-2966. PMID 2785912 DOI: 10.1210/Endo-124-6-2954 |
0.365 |
|
| 1989 |
Park SS, Waxman DJ, Lapenson DP, Schenkman JB, Gelboin HV. Monoclonal antibodies to rat liver cytochrome P-450 2c/RLM5 that regiospecifically inhibit steroid metabolism Biochemical Pharmacology. 38: 3067-3074. PMID 2783161 DOI: 10.1016/0006-2952(89)90017-8 |
0.342 |
|
| 1989 |
Koch JA, Waxman DJ. Posttranslational modification of hepatic cytochrome P-450. Phosphorylation of phenobarbital-inducible P-450 forms PB-4 (IIB1) and PB-5 (IIB2) in isolated rat hepatocytes and in vivo. Biochemistry. 28: 3145-52. PMID 2742831 DOI: 10.1021/Bi00434A005 |
0.342 |
|
| 1989 |
Oesch F, Waxman DJ, Morrissey JJ, Honscha W, Kissel W, Friedberg T. Antibodies targeted against hypervariable and constant regions of cytochromes P450IIB1 and P450IIB2. Archives of Biochemistry and Biophysics. 270: 23-32. PMID 2539047 DOI: 10.1016/0003-9861(89)90003-9 |
0.325 |
|
| 1989 |
Bartlomowicz B, Waxman DJ, Utesch D, Oesch F, Friedberg T. Phosphorylation of carcinogen metabolizing enzymes: regulation of the phosphorylation status of the major phenobarbital inducible cytochromes P-450 in hepatocytes. Carcinogenesis. 10: 225-8. PMID 2535970 DOI: 10.1093/Carcin/10.1.225 |
0.333 |
|
| 1989 |
Yeowell HN, Waxman DJ, LeBlanc GA, Linko P, Goldstein JA. Suppression of male-specific cytochrome P450 2c and its mRNA by 3,4,5,3′,4′,5′-hexachlorobiphenyl in rat liver is not causally related to changes in serum testosterone Archives of Biochemistry and Biophysics. 271: 508-514. PMID 2499261 DOI: 10.1016/0003-9861(89)90302-0 |
0.365 |
|
| 1988 |
Waxman DJ. Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression Biochemical Pharmacology. 37: 71-84. PMID 3276320 DOI: 10.1016/0006-2952(88)90756-3 |
0.353 |
|
| 1988 |
Waxman DJ, Attisano C, Guengerich FP, Lapenson DP. Human liver microsomal steroid metabolism: identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Archives of Biochemistry and Biophysics. 263: 424-36. PMID 3259858 DOI: 10.1016/0003-9861(88)90655-8 |
0.349 |
|
| 1988 |
Waxman DJ, Lapenson DP, Krishnan M, Bernard O, Kreibich G, Alvarez F. Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450. Gastroenterology. 95: 1326-31. PMID 3049217 DOI: 10.1016/0016-5085(88)90368-X |
0.367 |
|
| 1987 |
Friedberg T, Waxman DJ, Atchison M, Kumar A, Haaparanta T, Raphael C, Adesnik M. Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1. Biochemistry. 25: 7975-83. PMID 3801454 DOI: 10.1021/Bi00372A028 |
0.341 |
|
| 1987 |
Schwarz M, Peres G, Buchmann A, Friedberg T, Waxman DJ, Kunz W. Phenobarbital induction of cytochrome P-450 in normal and preneoplastic rat liver: comparison of enzyme and mRNA expression as detected by immunohistochemistry and in situ hybridization. Carcinogenesis. 8: 1355-7. PMID 3621474 DOI: 10.1093/Carcin/8.9.1355 |
0.376 |
|
| 1987 |
Clarke L, Waxman DJ. Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. Archives of Biochemistry and Biophysics. 256: 585-96. PMID 3619447 DOI: 10.1016/0003-9861(87)90616-3 |
0.341 |
|
| 1987 |
McClellan-Green P, Waxman DJ, Caveness M, Goldstein JA. Phenotypic differences in expression of cytochrome P-450g but not its mRNA in outbred male Sprague-Dawley rats. Archives of Biochemistry and Biophysics. 253: 13-25. PMID 3545082 DOI: 10.1016/0003-9861(87)90632-1 |
0.318 |
|
| 1987 |
Holsztynska EJ, Waxman DJ. Cytochrome P-450 cholesterol 7 alpha-hydroxylase: inhibition of enzyme deactivation by structurally diverse calmodulin antagonists and phosphatase inhibitors. Archives of Biochemistry and Biophysics. 256: 543-59. PMID 3039914 DOI: 10.1016/0003-9861(87)90612-6 |
0.304 |
|
| 1987 |
Wright JE, Rosowsky A, Waxman DJ, Trites D, Cucchi CA, Flatow J, Frei E. Metabolism of methotrexate and gamma-tert-butyl methotrexate by human leukemic cells in culture and by hepatic aldehyde oxidase in vitro. Biochemical Pharmacology. 36: 2209-14. PMID 2440437 DOI: 10.1016/0006-2952(87)90152-3 |
0.343 |
|
| 1986 |
Frey AB, Kreibich G, Wadhera AB, Clarke L, Waxman DJ. 3-(Trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine photolabels a substrate-binding site of rat hepatic cytochrome P-450 form PB-4. Biochemistry. 25: 4797-803. PMID 3768313 DOI: 10.1021/Bi00365A012 |
0.371 |
|
| 1986 |
Waxman DJ. Rat hepatic cholesterol 7α-hydroxylase: Biochemical properties and comparison to constitutive and xenobiotic-inducible cytochrome P-450 enzymes Archives of Biochemistry and Biophysics. 247: 335-345. PMID 3717947 DOI: 10.1016/0003-9861(86)90592-8 |
0.374 |
|
| 1986 |
Park SS, Waxman DJ, Miller H, Robinson R, Attisano C, Guengerich FP, Gelboin HV. Preparation and characterization of monoclonal antibodies to pregnenolone 16-alpha-carbonitrile inducible rat liver cytochrome P-450. Biochemical Pharmacology. 35: 2859-67. PMID 3488743 DOI: 10.1016/0006-2952(86)90477-6 |
0.335 |
|
| 1986 |
DANNAN GA, PORUBEK DJ, NELSON SD, WAXMAN DJ, GUENGERICH FP. 17β-Estradiol 2- and 4-Hydroxylation Catalyzed by Rat Hepatic Cytochrome P-450: Roles of Individual Forms, Inductive Effects, Developmental Patterns, and Alterations by Gonadectomy and Hormone Replacement* Endocrinology. 118: 1952-1960. DOI: 10.1210/Endo-118-5-1952 |
0.353 |
|
| 1985 |
Rampersaud A, Waxman DJ, Ryan DE, Levin W, Walz FG. Microheterogeneity of a male-specific rat hepatic cytochrome P-450: Existence of three allozymic forms Archives of Biochemistry and Biophysics. 243: 174-183. PMID 3840669 DOI: 10.1016/0003-9861(85)90786-6 |
0.337 |
|
| 1983 |
Waxman DJ, Walsh C. Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: purification, characterization, and interactions with metyrapone and cytochrome b5. Biochemistry. 22: 4846-55. PMID 6626536 DOI: 10.1021/Bi00289A035 |
0.489 |
|
| 1983 |
Waxman DJ, Strominger JL. Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics. Annual Review of Biochemistry. 52: 825-69. PMID 6351730 DOI: 10.1146/Annurev.Bi.52.070183.004141 |
0.402 |
|
| 1982 |
Waxman DJ, Light DR, Walsh C. Chiral sulfoxidations catalyzed by rat liver cytochromes P-450. Biochemistry. 21: 2499-507. PMID 7093200 DOI: 10.1021/Bi00539A032 |
0.488 |
|
| 1982 |
Light DR, Waxman DJ, Walsh C. Studies on the chirality of sulfoxidation catalyzed by bacterial flavoenzyme cyclohexanone monooxygenase and hog liver flavin adenine dinucleotide containing monooxygenase. Biochemistry. 21: 2490-8. PMID 7093199 DOI: 10.1021/Bi00539A031 |
0.458 |
|
| 1982 |
Yocum RR, Amanuma H, O'Brien TA, Waxman DJ, Strominger JL. Penicillin is an active-site inhibitor for four genera of bacteria. Journal of Bacteriology. 149: 1150-3. PMID 7061385 DOI: 10.1128/Jb.149.3.1150-1153.1982 |
0.445 |
|
| 1982 |
Waxman DJ, Amanuma H, Strominger JL. Amino acid sequence homologies between Escherichia coli penicillin-binding protein 5 and class A beta-lactamases. Febs Letters. 139: 159-63. PMID 7042389 DOI: 10.1016/0014-5793(82)80840-5 |
0.404 |
|
| 1981 |
Moews PC, Knox JR, Waxman DJ, Strominger JL. Secondary structure relations between beta-lactamases and penicillin-sensitive D-alanine-carboxypeptidases. International Journal of Peptide and Protein Research. 17: 211-8. PMID 6971815 DOI: 10.1111/J.1399-3011.1981.Tb01984.X |
0.412 |
|
| 1981 |
Waxman DJ, Lindgren DM, Strominger JL. High-molecular-weight penicillin-binding proteins from membranes of bacilli. Journal of Bacteriology. 148: 950-5. PMID 6796565 DOI: 10.1128/Jb.148.3.950-955.1981 |
0.437 |
|
| 1981 |
Waxman DJ, Strominger JL. Primary structure of the COOH-terminal membranous segment of a penicillin-sensitive enzyme purified from two Bacilli. The Journal of Biological Chemistry. 256: 2067-77. PMID 6780559 |
0.335 |
|
| 1981 |
Waxman DJ, Strominger JL. Limited proteolysis of the penicillin-sensitive D-alanine carboxypeptidase purified from Bacillus subtilis membranes. Active water-soluble fragments generated by cleavage of a COOH-terminal membrane anchor. The Journal of Biological Chemistry. 256: 2059-66. PMID 6780558 |
0.325 |
|
| 1980 |
Waxman DJ, Yu W, Strominger JL. Linear, uncross-linked peptidoglycan secreted by penicillin-treated Bacillus subtilis. Isolation and characterization as a substrate for penicillin-sensitive D-alanine carboxypeptidases. The Journal of Biological Chemistry. 255: 11577-87. PMID 6777380 |
0.361 |
|
| 1980 |
Waxman DJ, Strominger JL. Sequence of active site peptides from the penicillin-sensitive D-alanine carboxypeptidase of Bacillus subtilis. Mechanism of penicillin action and sequence homology to beta-lactamases. The Journal of Biological Chemistry. 255: 3964-76. PMID 6768745 |
0.367 |
|
| 1980 |
Waxman DJ, Yocum RR, Strominger JL. Penicillins and cephalosporins are active site-directed acylating agents: evidence in support of the substrate analogue hypothesis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 289: 257-71. PMID 6109322 DOI: 10.1098/Rstb.1980.0044 |
0.464 |
|
| 1980 |
Rogers Yocum R, Waxman DJ, Strominger JL. Interaction of penicillin with its receptors in bacterial membranes Trends in Biochemical Sciences. 5: 97-101. DOI: 10.1016/0968-0004(80)90258-3 |
0.471 |
|
| 1979 |
Waxman DJ, Strominger JL. Cleavage of a COOH-terminal hydrophobic region from D-alanine carboxypeptidase, a penicillin-sensitive bacterial membrane enzyme. Characterization of active, water-soluble fragments. The Journal of Biological Chemistry. 254: 4863-75. PMID 438218 |
0.361 |
|
| 1979 |
Waxman DJ, Strominger JL. Cephalosporin-sensitive penicillin-binding proteins of Staphylococcus aureus and Bacillus subtilis active in the conversion of [14C]penicillin G to [14C]phenylacetylglycine. The Journal of Biological Chemistry. 254: 12056-61. PMID 115876 |
0.351 |
|
| 1979 |
Yocum RR, Waxman DJ, Rasmussen JR, Strominger JL. Mechanism of penicillin action: penicillin and substrate bind covalently to the same active site serine in two bacterial D-alanine carboxypeptidases. Proceedings of the National Academy of Sciences of the United States of America. 76: 2730-4. PMID 111240 DOI: 10.1073/Pnas.76.6.2730 |
0.463 |
|
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