Daniel A. Harki - Publications

1999-2005 Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Shi K, Moeller NH, Banerjee S, McCann JL, Carpenter MA, Yin L, Moorthy R, Orellana K, Harki DA, Harris RS, Aihara H. Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33658373 DOI: 10.1073/pnas.2021120118  0.64
2021 Grenning AJ, Emmetiere F, Ratnayake R, Schares HAM, Jones KFM, Bevan-Smith E, Luesch H, Harki DA. Function-oriented and modular (+/-)-cis-pseudoguaianolide synthesis: Discovery of new Nrf2 Activators and NF-κB Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 33502811 DOI: 10.1002/chem.202100038  0.4
2020 Jackson PA, Schares HAM, Jones KFM, Widen JC, Dempe DP, Grillet F, Cuellar ME, Walters MA, Harki DA, Brummond KM. Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. Journal of Medicinal Chemistry. PMID 33201697 DOI: 10.1021/acs.jmedchem.0c01464  0.68
2020 Shi K, Demir Ö, Carpenter MA, Banerjee S, Harki DA, Amaro RE, Harris RS, Aihara H. Active site plasticity and possible modes of chemical inhibition of the human DNA deaminase APOBEC3B. Faseb Bioadvances. 2: 49-58. PMID 32123856 DOI: 10.1096/fba.2019-00068  0.64
2019 Kvach MV, Barzak FM, Harjes S, Schares HAM, Kurup HM, Jones KF, Sutton L, Donahue J, D'Aquila RT, Jameson GB, Harki DA, Krause KL, Harjes E, Filichev V. Differential inhibition of APOBEC3 DNA-mutator isozymes by fluoro- versus non-fluoro-substituted 2'-deoxyzebularine embedded in single-stranded DNA. Chembiochem : a European Journal of Chemical Biology. PMID 31633265 DOI: 10.1002/Cbic.201900505  0.4
2018 Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev V, Harki DA, Harjes E. Inhibiting APOBEC3 activity with single-stranded DNA containing 2'-deoxyzebularine analogs. Biochemistry. PMID 30418757 DOI: 10.1021/Acs.Biochem.8B00858  0.64
2018 Divakaran A, Talluri SK, Ayoub AM, Mishra N, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schönbrunn E, Harki DA, Pomerantz WCK. Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of Medicinal Chemistry. PMID 30253095 DOI: 10.1021/Acs.Jmedchem.8B01248  0.68
2018 Wagner JR, Demir O, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE. Determinants of Oligonucleotide Selectivity of APOBEC3B. Journal of Chemical Information and Modeling. PMID 30130104 DOI: 10.1021/Acs.Jcim.8B00427  0.64
2018 Naumann JA, Widen JC, Jonart LA, Ebadi M, Tang J, Gordon DJ, Harki DA, Gordon PM. SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy. Bioconjugate Chemistry. PMID 29412642 DOI: 10.1021/Acs.Bioconjchem.7B00774  0.68
2018 Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA. Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Chemmedchem. PMID 29349898 DOI: 10.1002/Cmdc.201700752  0.68
2017 Olson ME, Harris RS, Harki DA. APOBEC Enzymes as Targets for Virus and Cancer Therapy. Cell Chemical Biology. PMID 29153851 DOI: 10.1016/J.Chembiol.2017.10.007  1
2017 Dulin D, Arnold JJ, van Laar T, Oh HS, Lee C, Perkins AL, Harki DA, Depken M, Cameron CE, Dekker NH. Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers. Cell Reports. 21: 1063-1076. PMID 29069588 DOI: 10.1016/J.Celrep.2017.10.005  0.56
2017 Widen JC, Kempema AM, Villalta PW, Harki DA. Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile. Acs Chemical Biology. 12: 102-113. PMID 28103680 DOI: 10.1021/Acschembio.6B00751  0.68
2017 Demir O, Wagner JR, Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Harki D, Aihara H, Amaro RE, Harris RS. Abstract 5236: The dynamic interplay between the cancer genome mutating enzyme APOBEC3B and DNA substrates Cancer Research. 77: 5236-5236. DOI: 10.1158/1538-7445.Am2017-5236  0.64
2016 Breunig SL, Olson ME, Harki DA. Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles. Tetrahedron Letters. 57: 4056-4060. PMID 28138199 DOI: 10.1016/J.Tetlet.2016.07.082  1
2016 Jackson PA, Widen JC, Harki DA, Brummond KM. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry. PMID 27996267 DOI: 10.1021/Acs.Jmedchem.6B00788  0.68
2016 Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H. Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nature Structural & Molecular Biology. PMID 27991903 DOI: 10.1038/Nsmb.3344  0.64
2016 Richards CM, Li M, Perkins AL, Rathore A, Harki DA, Harris RS. Reassessing APOBEC3G inhibition by HIV-1 Vif-derived peptides. Journal of Molecular Biology. PMID 27887868 DOI: 10.1016/J.Jmb.2016.11.012  0.64
2016 Wells SM, Widen JC, Harki DA, Brummond KM. Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction. Organic Letters. PMID 27570975 DOI: 10.1021/Acs.Orglett.6B02088  0.68
2016 Perkins AL, Peterson KL, Beito TG, Flatten KS, Kaufmann SH, Harki DA. Synthesis of a peptide-universal nucleotide antigen: towards next-generation antibodies to detect topoisomerase I-DNA covalent complexes. Organic & Biomolecular Chemistry. 14: 4103-9. PMID 27113574 DOI: 10.1039/C5Ob02049B  1
2016 Struntz NB, Harki DA. Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors. Acs Chemical Biology. PMID 27054264 DOI: 10.1021/Acschembio.6B00130  1
2016 Patel AG, Flatten KS, Peterson KL, Beito TG, Schneider PA, Perkins AL, Harki DA, Kaufmann SH. Immunodetection of human topoisomerase I-DNA covalent complexes. Nucleic Acids Research. PMID 26917015 DOI: 10.1093/Nar/Gkw109  1
2016 Breunig SL, Olson ME, Harki DA. Rapid, microwave accelerated synthesis of [1,2,4]triazolo[3,4-b][1,3,4]oxadiazoles from 4-acylamino-1,2,4-triazoles Tetrahedron Letters. 57: 4056-4060. DOI: 10.1016/j.tetlet.2016.07.082  1
2015 Richards C, Albin JS, Demir Ö, Shaban NM, Luengas EM, Land AM, Anderson BD, Holten JR, Anderson JS, Harki DA, Amaro RE, Harris RS. The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches. Cell Reports. PMID 26628363 DOI: 10.1016/J.Celrep.2015.10.067  0.64
2015 Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW. Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nature Communications. 6: 8526. PMID 26446751 DOI: 10.1038/Ncomms9526  1
2015 Olson ME, Abate-Pella D, Perkins AL, Li M, Carpenter MA, Rathore A, Harris RS, Harki DA. Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries. Journal of Medicinal Chemistry. PMID 26358009 DOI: 10.1021/Acs.Jmedchem.5B00930  1
2015 Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry. 23: 4737-45. PMID 26088334 DOI: 10.1016/J.Bmc.2015.05.037  1
2015 Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Parthenolide prodrug LC-1 slows growth of intracranial glioma. Bioorganic & Medicinal Chemistry Letters. 25: 2493-5. PMID 25978958 DOI: 10.1016/J.Bmcl.2015.04.058  1
2015 Brand LJ, Olson ME, Ravindranathan P, Guo H, Kempema AM, Andrews TE, Chen X, Raj GV, Harki DA, Dehm SM. EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 6: 3811-24. PMID 25669987 DOI: 10.18632/Oncotarget.2924  1
2013 Andrews TE, Wang D, Harki DA. Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery. Drug Delivery and Translational Research. 3: 121-42. PMID 25787981 DOI: 10.1007/S13346-012-0075-1  1
2013 Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. A redox economical synthesis of bioactive 6,12-guaianolides. Organic Letters. 15: 2644-7. PMID 23662902 DOI: 10.1021/Ol400904Y  1
2013 Olson ME, Li M, Harris RS, Harki DA. Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold. Chemmedchem. 8: 112-7. PMID 23180603 DOI: 10.1002/Cmdc.201200411  1
2012 Struntz NB, Hu T, White BR, Olson ME, Harki DA. Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP. Chembiochem : a European Journal of Chemical Biology. 13: 2517-20. PMID 23097382 DOI: 10.1002/Cbic.201200503  1
2012 Hexum JK, Tello-Aburto R, Struntz NB, Harned AM, Harki DA. Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling. Acs Medicinal Chemistry Letters. 3: 459-464. PMID 22866208 DOI: 10.1021/Ml300034A  1
2012 Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, et al. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. Acs Chemical Biology. 7: 506-17. PMID 22181350 DOI: 10.1021/Cb200440Y  1
2011 Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry. 50: 10431-41. PMID 22039883 DOI: 10.1021/Bi200962U  1
2009 Chenoweth DM, Harki DA, Dervan PB. Oligomerization route to Py-Im polyamide macrocycles. Organic Letters. 11: 3590-3. PMID 19627138 DOI: 10.1021/Ol901311M  1
2009 Chenoweth DM, Harki DA, Dervan PB. Solution-phase synthesis of pyrrole-imidazole polyamides. Journal of the American Chemical Society. 131: 7175-81. PMID 19413320 DOI: 10.1021/Ja901307M  1
2009 Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB. Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. Journal of the American Chemical Society. 131: 7182-8. PMID 19413319 DOI: 10.1021/Ja901309Z  1
2008 Harki DA, Satyamurthy N, Stout DB, Phelps ME, Dervan PB. In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 105: 13039-44. PMID 18753620 DOI: 10.1073/Pnas.0806308105  1
2008 Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK. Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. The Journal of Biological Chemistry. 283: 7705-12. PMID 18184655 DOI: 10.1074/Jbc.M709563200  1
2008 Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM, Peterson BR, Loakes D, Brown DM, Cameron CE. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrobial Agents and Chemotherapy. 52: 971-9. PMID 18180344 DOI: 10.1128/Aac.01056-07  0.56
2007 Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE. Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. Journal of Virology. 81: 11256-66. PMID 17686844 DOI: 10.1128/Jvi.01028-07  1
2007 Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Chembiochem : a European Journal of Chemical Biology. 8: 1359-62. PMID 17600792 DOI: 10.1002/Cbic.200700160  1
2006 Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. Journal of Medicinal Chemistry. 49: 6166-9. PMID 17034123 DOI: 10.1021/Jm060872X  1
2003 Simeonova PP, Hulderman T, Harki D, Luster MI. Arsenic exposure accelerates atherogenesis in apolipoprotein E-/- mice Environmental Health Perspectives. 111: 1744-1748. PMID 14594625 DOI: 10.1289/Ehp.6332  1
2002 Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry. 41: 9026-33. PMID 12119016 DOI: 10.1021/Bi026120W  1
2000 Simeonova PP, Wang S, Toriuma W, Kommineni V, Matheson J, Unimye N, Kayama F, Harki D, Ding M, Vallyathan V, Luster MI. Arsenic mediates cell proliferation and gene expression in the bladder epithelium association with activating protein-1 transactivation Cancer Research. 60: 3445-3453. PMID 10910055  1
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