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Sylvie Garneau-Tsodikova, Ph.D. - Publications

2013- Chemistry University of Kentucky, Lexington, KY 
synthetic biology, neurodegeneration

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Thamban Chandrika N, Dennis EK, Brubaker KR, Kwiatkowski S, Watt DS, Garneau-Tsodikova S. Broad-Spectrum Antifungal Agents: Fluorinated Aryl- and Heteroaryl-Substituted Hydrazones. Chemmedchem. PMID 33063957 DOI: 10.1002/cmdc.202000626  0.72
2020 Howard KC, Gonzalez OA, Garneau-Tsodikova S. Second Generation of Zafirlukast Derivatives with Improved Activity against the Oral Pathogen . Acs Medicinal Chemistry Letters. 11: 1905-1912. PMID 33062172 DOI: 10.1021/acsmedchemlett.9b00614  0.56
2020 Mori S, Garneau-Tsodikova S, Tsodikov OV. Unimodular Methylation by Adenylation-Thiolation Domains Containing an Embedded Methyltransferase. Journal of Molecular Biology. PMID 32920052 DOI: 10.1016/j.jmb.2020.09.004  0.8
2020 Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S. Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from . Acs Chemical Biology. PMID 32421305 DOI: 10.1021/acschembio.0c00184  0.88
2020 Howard KC, Dennis EK, Watt DS, Garneau-Tsodikova S. A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise. Chemical Society Reviews. PMID 32140691 DOI: 10.1039/c9cs00556k  0.64
2020 Ying L, Zhu H, Fosso MY, Garneau-Tsodikova S, Fredrick K. Modified Aminoglycosides Bind Nucleic Acids in High-Molecular-Weight Complexes. Antibiotics (Basel, Switzerland). 9. PMID 32098020 DOI: 10.3390/antibiotics9020093  0.72
2019 Lundy TA, Mori S, Thamban Chandrika N, Garneau-Tsodikova S. Characterization of a Unique Interrupted Adenylation Domain That Can Catalyze Three Reactions. Acs Chemical Biology. PMID 31887013 DOI: 10.1021/acschembio.9b00929  0.72
2019 Thamban Chandrika N, Fosso MY, Tsodikov OV, LeVine Iii H, Garneau-Tsodikova S. Combining Chalcones with Donepezil to Inhibit Both Cholinesterases and Aβ Fibril Assembly. Molecules (Basel, Switzerland). 25. PMID 31878304 DOI: 10.3390/molecules25010077  0.8
2019 Dennis EK, Kim JH, Parkin S, Awuah SG, Garneau-Tsodikova S. Distorted Gold(I)-Phosphine Complexes as Antifungal Agents. Journal of Medicinal Chemistry. PMID 31841324 DOI: 10.1021/acs.jmedchem.9b01436  0.64
2019 Green KD, Punetha A, Hou C, Garneau-Tsodikova S, Tsodikov OV. Probing the Robustness of Inhibitors of Tuberculosis Aminoglycoside Resistance Enzyme Eis by Mutagenesis. Acs Infectious Diseases. PMID 31433614 DOI: 10.1021/acsinfecdis.9b00228  0.88
2019 Thamban Chandrika N, Fosso MY, Alimova Y, May A, Gonzalez OA, Garneau-Tsodikova S. Novel zafirlukast derivatives exhibit selective antibacterial activity against . Medchemcomm. 10: 926-933. PMID 31303990 DOI: 10.1039/c9md00074g  0.72
2019 Mori S, Pang AH, Chandrika NT, Garneau-Tsodikova S, Tsodikov OV. Publisher Correction: Unusual substrate and halide versatility of phenolic halogenase PltM. Nature Communications. 10: 2053. PMID 31040284 DOI: 10.1038/s41467-019-09731-8  0.8
2019 Mori S, Pang AH, Thamban Chandrika N, Garneau-Tsodikova S, Tsodikov OV. Unusual substrate and halide versatility of phenolic halogenase PltM. Nature Communications. 10: 1255. PMID 30890712 DOI: 10.1038/s41467-019-09215-9  0.8
2019 Green KD, Fosso MY, Mayhoub AS, Garneau-Tsodikova S. Investigating the promiscuity of the chloramphenicol nitroreductase from Haemophilus influenzae towards the reduction of 4-nitrobenzene derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 30826292 DOI: 10.1016/j.bmcl.2019.02.025  0.88
2019 Lundy TA, Mori S, Garneau-Tsodikova S. Probing the limits of interrupted adenylation domains by engineering a trifunctional enzyme capable of adenylation, N-, and S-methylation. Organic & Biomolecular Chemistry. PMID 30644493 DOI: 10.1039/c8ob02996b  0.6
2018 Thamban Chandrika N, Dennis EK, Shrestha SK, Ngo HX, Green KD, Kwiatkowski S, Deaciuc AG, Dwoskin LP, Watt DS, Garneau-Tsodikova S. N,N'-diaryl-bishydrazones in a biphenyl platform: Broad spectrum antifungal agents. European Journal of Medicinal Chemistry. 164: 273-281. PMID 30597328 DOI: 10.1016/j.ejmech.2018.12.042  0.88
2018 Green KD, Fosso MY, Garneau-Tsodikova S. Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors. Molecules (Basel, Switzerland). 23. PMID 30544832 DOI: 10.3390/molecules23123252  0.88
2018 Story S, Skriba MJ, Maiti K, Nihar Ranjan, Degtyareva NN, Green KD, Khodaverdian V, Oyelere AK, Garneau-Tsodikova S, Arya DP. Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates. European Journal of Medicinal Chemistry. 163: 381-393. PMID 30530174 DOI: 10.1016/j.ejmech.2018.11.022  0.88
2018 Dennis EK, Garneau-Tsodikova S. Synergistic combinations of azoles and antihistamines against Candida species in vitro. Medical Mycology. PMID 30295881 DOI: 10.1093/mmy/myy088  0.64
2018 Mori S, Garneau-Tsodikova S. Making figures: are you taking the best approach to maximize visibility? Medchemcomm. 9: 1399-1403. PMID 30288216 DOI: 10.1039/c8md90036a  0.6
2018 Scutigliani EM, Scholl ER, Grootemaat AE, Khanal S, Kochan JA, Krawczyk PM, Reits EA, Garzan A, Ngo HX, Green KD, Garneau-Tsodikova S, Ruijter JM, van Veen HA, van der Wel NN. Interfering With DNA Decondensation as a Strategy Against Mycobacteria. Frontiers in Microbiology. 9: 2034. PMID 30233521 DOI: 10.3389/fmicb.2018.02034  0.88
2018 Holbrook SYL, Gentry MS, Tsodikov OV, Garneau-Tsodikova S. Nucleoside triphosphate cosubstrates control the substrate profile and efficiency of aminoglycoside 3'--phosphotransferase type IIa. Medchemcomm. 9: 1332-1339. PMID 30151088 DOI: 10.1039/c8md00234g  0.8
2018 Mori S, Green KD, Choi R, Buchko GW, Fried MG, Garneau-Tsodikova S. Using MbtH-like proteins to alter substrate profile of a nonribosomal peptide adenylation enzyme. Chembiochem : a European Journal of Chemical Biology. PMID 30134012 DOI: 10.1002/cbic.201800240  0.88
2018 Ngo HX, Garneau-Tsodikova S. What are the drugs of the future? Medchemcomm. 9: 757-758. PMID 30108965 DOI: 10.1039/c8md90019a  0.68
2018 Louzoun Zada S, Green KD, Shrestha SK, Herzog IM, Garneau-Tsodikova S, Fridman M. Derivatives of Ribosome-Inhibiting Antibiotic Chloramphenicol Inhibit the Biosynthesis of Bacterial Cell Wall. Acs Infectious Diseases. PMID 29714997 DOI: 10.1021/acsinfecdis.8b00078  0.88
2018 Fosso MY, Shrestha SK, Thamban Chandrika N, Dennis EK, Green KD, Garneau-Tsodikova S. Differential Effects of Linkers on the Activity of Amphiphilic Tobramycin Antifungals. Molecules (Basel, Switzerland). 23. PMID 29652845 DOI: 10.3390/molecules23040899  0.88
2018 Ngo HX, Green KD, Gajadeera CS, Willby MJ, Holbrook SYL, Hou C, Garzan A, Mayhoub AS, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Potent 1,2,4-Triazino[5,6 b]indole-3-thioether Inhibitors of the Kanamycin Resistance Enzyme Eis from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 29601176 DOI: 10.1021/acsinfecdis.8b00074  0.88
2018 Mori S, Pang AH, Lundy TA, Garzan A, Tsodikov OV, Garneau-Tsodikova S. Structural basis for backbone N-methylation by an interrupted adenylation domain. Nature Chemical Biology. PMID 29556104 DOI: 10.1038/s41589-018-0014-7  0.8
2018 Lundy TA, Mori S, Garneau-Tsodikova S. Engineering Bifunctional Enzymes Capable of Adenylating and Selectively Methylating the Side Chain or Core of Amino Acids. Acs Synthetic Biology. PMID 29393631 DOI: 10.1021/acssynbio.7b00426  0.6
2018 Green KD, Biswas T, Pang AH, Willby MJ, Reed MS, Stuchlik O, Pohl J, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight. Biochemistry. PMID 29345920 DOI: 10.1021/acs.biochem.7b01089  0.88
2018 Thamban Chandrika N, Garneau-Tsodikova S. Comprehensive review of chemical strategies for the preparation of new aminoglycosides and their biological activities. Chemical Society Reviews. PMID 29296992 DOI: 10.1039/c7cs00407a  0.72
2017 Holbrook SYL, Garneau-Tsodikova S. What is medicinal chemistry? - Demystifying a rapidly evolving discipline! Medchemcomm. 8: 1739-1741. PMID 30108885 DOI: 10.1039/c7md90030a  0.64
2017 Thamban Chandrika N, Shrestha SK, Ngo HX, Howard KC, Garneau-Tsodikova S. Novel fluconazole derivatives with promising antifungal activity. Bioorganic & Medicinal Chemistry. PMID 29279242 DOI: 10.1016/j.bmc.2017.12.018  0.84
2017 Holbrook SYL, Garneau-Tsodikova S. Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical Isolates. Microbial Drug Resistance (Larchmont, N.Y.). PMID 29261405 DOI: 10.1089/mdr.2017.0101  0.64
2017 Thamban Chandrika N, Shrestha SK, Ngo HX, Tsodikov OV, Howard KC, Garneau-Tsodikova S. Alkylated Piperazines and Piperazine-Azole Hybrids as Antifungal Agents. Journal of Medicinal Chemistry. PMID 29256601 DOI: 10.1021/acs.jmedchem.7b01138  0.84
2017 Thamban Chandrika N, Shrestha SK, Ranjan N, Sharma A, Arya DP, Garneau-Tsodikova S. New Application of Neomycin B-Bisbenzimidazole Hybrids as Antifungal Agents. Acs Infectious Diseases. PMID 29227087 DOI: 10.1021/acsinfecdis.7b00254  0.84
2017 Mori S, Garzan A, Tsodikov OV, Garneau-Tsodikova S. Deciphering Nature's Intricate Way of N,S-Dimethylating l-Cysteine: Sequential Action of Two Bifunctional Adenylation Domains. Biochemistry. PMID 29112395 DOI: 10.1021/acs.biochem.7b00980  0.8
2017 Holbrook SYL, Garzan A, Dennis EK, Shrestha SK, Garneau-Tsodikova S. Repurposing antipsychotic drugs into antifungal agents: Synergistic combinations of azoles and bromperidol derivatives in the treatment of various fungal infections. European Journal of Medicinal Chemistry. 139: 12-21. PMID 28797882 DOI: 10.1016/j.ejmech.2017.07.030  0.84
2017 Mori S, Shrestha SK, Fernández J, Álvarez San Millán M, Garzan A, Al-Mestarihi AH, Lombó F, Garneau-Tsodikova S. Activation and loading of the starter unit during thiocoraline biosynthesis. Biochemistry. PMID 28762729 DOI: 10.1021/acs.biochem.7b00661  0.84
2017 Bobrov AG, Kirillina O, Fosso MY, Fetherston JD, Miller MC, VanCleave TT, Burlison JA, Arnold WK, Lawrenz MB, Garneau-Tsodikova S, Perry RD. Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice. Metallomics : Integrated Biometal Science. PMID 28540946 DOI: 10.1039/c7mt00126f  0.72
2017 Shrestha SK, Garzan A, Garneau-Tsodikova S. Novel alkylated azoles as potent antifungals. European Journal of Medicinal Chemistry. 133: 309-318. PMID 28395217 DOI: 10.1016/j.ejmech.2017.03.075  0.84
2017 Garzan A, Willby MJ, Ngo HX, Gajadeera CS, Green KD, Holbrook SY, Hou C, Posey JE, Tsodikov OV, Garneau-Tsodikova S. Combating Eis-mediated kanamycin resistance of M. tuber-culosis by novel pyrrolo[1,5-a]pyrazine-based Eis inhibitors. Acs Infectious Diseases. PMID 28192916 DOI: 10.1021/acsinfecdis.6b00193  0.88
2017 Degtyareva NN, Gong C, Story S, Levinson N, Oyelere AK, Green KD, Garneau-Tsodikova S, Arya DP. Antimicrobial Activity, AME Resistance and Translation Inhibition Studies of Anthraquinone-Neomycin Conjugates. Acs Infectious Diseases. PMID 28103015 DOI: 10.1021/acsinfecdis.6b00176  0.88
2017 Pang AH, Garneau-Tsodikova S, Tsodikov OV. In Vitro Assays to Identify Antibiotics Targeting DNA Metabolism. Methods in Molecular Biology (Clifton, N.J.). 1520: 175-200. PMID 27873253 DOI: 10.1007/978-1-4939-6634-9_11  0.8
2016 Garzan A, Willby MJ, Green KD, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Discovery and Optimization of Two Eis Inhibitor Families as Kanamycin Adjuvants against Drug-Resistant M. tuberculosis. Acs Medicinal Chemistry Letters. 7: 1219-1221. PMID 27994767 DOI: 10.1021/acsmedchemlett.6b00261  0.88
2016 Garzan A, Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis. Journal of Medicinal Chemistry. 59: 10619-10628. PMID 27933949 DOI: 10.1021/acs.jmedchem.6b01161  0.88
2016 Shrestha SK, Kril LM, Green KD, Kwiatkowski S, Sviripa VM, Nickell JR, Dwoskin LP, Watt DS, Garneau-Tsodikova S. Bis(N-amidinohydrazones) and N-(amidino)-N'-aryl-bishydrazones: New classes of antibacterial/antifungal agents. Bioorganic & Medicinal Chemistry. PMID 27769670 DOI: 10.1016/j.bmc.2016.10.009  0.88
2016 Ngo HX, Garneau-Tsodikova S, Green KD. A complex game of hide and seek: the search for new antifungals. Medchemcomm. 7: 1285-1306. PMID 27766140 DOI: 10.1039/C6MD00222F  0.88
2016 Pang AH, Garzan A, Larsen MJ, McQuade TJ, Garneau-Tsodikova S, Tsodikov OV. Discovery of allosteric and selective inhibitors of inorganic pyrophosphatase from Mycobacterium tuberculosis. Acs Chemical Biology. PMID 27622287 DOI: 10.1021/acschembio.6b00510  0.8
2016 Holbrook SY, Garneau-Tsodikova S. Expanding aminoglycoside resistance enzyme regiospecificity by mutation and truncation. Biochemistry. PMID 27618454 DOI: 10.1021/acs.biochem.6b00770  1
2016 Ngo HX, Garneau-Tsodikova S. Flipping the Switch "On" for Aminoglycoside-Resistance Enzymes: The Mechanism Is Finally Revealed! Structure (London, England : 1993). 24: 1011-3. PMID 27387794 DOI: 10.1016/j.str.2016.06.006  0.68
2016 Ngo HX, Shrestha SK, Garneau-Tsodikova S. Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity. Chemmedchem. PMID 27334363 DOI: 10.1002/cmdc.201600236  1
2016 Piddock L, Garneau-Tsodikova S, Garner C. Ask the experts: how to curb antibiotic resistance and plug the antibiotics gap? Future Medicinal Chemistry. PMID 27327784 DOI: 10.4155/fmc-2014-0032  1
2016 Chandrika NT, Shrestha SK, Ngo HX, Garneau-Tsodikova S. Synthesis and investigation of novel benzimidazole derivatives as antifungal agents. Bioorganic & Medicinal Chemistry. PMID 27301676 DOI: 10.1016/j.bmc.2016.06.010  1
2016 Shrestha SK, Garneau-Tsodikova S. Expanding substrate promiscuity by engineering novel adenylating-methylating NRPS bifunctional enzyme. Chembiochem : a European Journal of Chemical Biology. PMID 27128382 DOI: 10.1002/cbic.201600234  1
2016 Ngo HX, Shrestha SK, Green KD, Garneau-Tsodikova S. Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus. Bioorganic & Medicinal Chemistry. PMID 27073054 DOI: 10.1016/j.bmc.2016.03.060  1
2016 Liu X, Jin Y, Cai W, Green KD, Goswami A, Garneau-Tsodikova S, Nonaka K, Baba S, Funabashi M, Yang Z, Van Lanen SG. A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW. Organic & Biomolecular Chemistry. PMID 27050157 DOI: 10.1039/c6ob00381h  1
2016 Chandrika NT, Garneau-Tsodikova S. A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides. Medchemcomm. 7: 50-68. PMID 27019689 DOI: 10.1039/C5MD00453E  0.48
2016 Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Potent inhibitors of acetyltransferase Eis overcome kanamycin re-sistance in Mycobacterium tuberculosis. Acs Chemical Biology. PMID 27010218 DOI: 10.1021/acschembio.6b00110  1
2016 Garneau-Tsodikova S, Labby KJ. Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives. Medchemcomm. 7: 11-27. PMID 26877861 DOI: 10.1039/C5MD00344J  1
2016 Jin Y, Watkins D, Degtyareva NN, Green KD, Spano MN, Garneau-Tsodikova S, Arya DP. Arginine-linked neomycin B dimers: synthesis, rRNA binding, and resistance enzyme activity. Medchemcomm. 7: 164-169. PMID 26811742 DOI: 10.1039/C5MD00427F  1
2016 Ngo HX, Garneau-Tsodikova S, Green KD. A complex game of hide and seek: The search for new antifungals Medchemcomm. 7: 1285-1306. DOI: 10.1039/c6md00222f  1
2016 Garneau-Tsodikova S, Wright GD. Antibiotic Resistance themed issue Medchemcomm. 7: 10. DOI: 10.1039/c5md90063h  1
2016 Chandrika NT, Garneau-Tsodikova S. A review of patents (2011-2015) towards combating resistance to and toxicity of aminoglycosides Medchemcomm. 7: 50-68. DOI: 10.1039/c5md00453e  1
2015 Green KD, Pricer RE, Stewart MN, Garneau-Tsodikova S. Comparative Study of Eis-like Enzymes from Pathogenic and Nonpathogenic Bacteria. Acs Infectious Diseases. 1: 272-83. PMID 27622743 DOI: 10.1021/acsinfecdis.5b00036  1
2015 Fosso MY, McCarty KL, Head E, Garneau-Tsodikova S, Levine Iii H. Differential effects of structural modifications on the competition of chalcones for the PIB amyloid imaging ligand-binding site in Alzheimer's disease brain and synthetic Aβ fibrils. Acs Chemical Neuroscience. PMID 26682772 DOI: 10.1021/acschemneuro.5b00266  1
2015 Thamban Chandrika N, Green KD, Houghton JL, Garneau-Tsodikova S. Synthesis and Biological Activity of Mono- and Di-N-acylated Aminoglycosides. Acs Medicinal Chemistry Letters. 6: 1134-1139. PMID 26617967 DOI: 10.1021/acsmedchemlett.5b00255  1
2015 Shrestha SK, Fosso MY, Garneau-Tsodikova S. A combination approach to treating fungal infections. Scientific Reports. 5: 17070. PMID 26594050 DOI: 10.1038/srep17070  1
2015 Fosso MY, Shrestha SK, Green KD, Garneau-Tsodikova S. Synthesis and bioactivities of kanamycin B-derived cationic amphiphiles. Journal of Medicinal Chemistry. PMID 26592740 DOI: 10.1021/acs.jmedchem.5b01375  1
2015 Pang AH, Garneau-Tsodikova S, Tsodikov OV. Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway. Journal of Structural Biology. PMID 26416533 DOI: 10.1016/j.jsb.2015.09.013  1
2015 Fosso MY, LeVine H, Green KD, Tsodikov OV, Garneau-Tsodikova S. Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones. Organic & Biomolecular Chemistry. 13: 9418-26. PMID 26248214 DOI: 10.1039/c5ob01478f  0.88
2015 Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Doudna Cate JH, Blanchard SC. Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nature Communications. 6: 7896. PMID 26224058 DOI: 10.1038/ncomms8896  1
2015 Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S. Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution. Bmc Structural Biology. 15: 13. PMID 26170207 DOI: 10.1186/s12900-015-0040-6  1
2015 Shrestha SK, Fosso MY, Green KD, Garneau-Tsodikova S. Amphiphilic Tobramycin Analogues as Antibacterial and Antifungal Agents. Antimicrobial Agents and Chemotherapy. 59: 4861-9. PMID 26033722 DOI: 10.1128/AAC.00229-15  1
2015 Fosso MY, Zhu H, Green KD, Garneau-Tsodikova S, Fredrick K. Tobramycin Variants with Enhanced Ribosome-Targeting Activity. Chembiochem : a European Journal of Chemical Biology. 16: 1565-70. PMID 26033429 DOI: 10.1002/cbic.201500256  1
2015 Al-Mestarihi AH, Garzan A, Kim JM, Garneau-Tsodikova S. Enzymatic Evidence for a Revised Congocidine Biosynthetic Pathway. Chembiochem : a European Journal of Chemical Biology. 16: 1307-13. PMID 25958990 DOI: 10.1002/cbic.201402711  1
2015 Li Y, Green KD, Johnson BR, Garneau-Tsodikova S. Inhibition of Aminoglycoside Acetyltransferase Resistance Enzymes by Metal Salts. Antimicrobial Agents and Chemotherapy. 59: 4148-56. PMID 25941215 DOI: 10.1128/AAC.00885-15  1
2015 Green KD, Biswas T, Chang C, Wu R, Chen W, Janes BK, Chalupska D, Gornicki P, Hanna PC, Tsodikov OV, Joachimiak A, Garneau-Tsodikova S. Biochemical and Structural Analysis of an Eis Family Aminoglycoside Acetyltransferase from Bacillus anthracis. Biochemistry. 54: 3197-206. PMID 25928210 DOI: 10.1021/acs.biochem.5b00244  1
2015 Watkins D, Kumar S, Green KD, Arya DP, Garneau-Tsodikova S. Influence of Linker Length and Composition on Enzymatic Activity and Ribosomal Binding of Neomycin Dimers. Antimicrobial Agents and Chemotherapy. 59: 3899-905. PMID 25896697 DOI: 10.1128/AAC.00861-15  1
2015 Cai W, Goswami A, Yang Z, Liu X, Green KD, Barnard-Britson S, Baba S, Funabashi M, Nonaka K, Sunkara M, Morris AJ, Spork AP, Ducho C, Garneau-Tsodikova S, Thorson JS, et al. The Biosynthesis of Capuramycin-type Antibiotics: IDENTIFICATION OF THE A-102395 BIOSYNTHETIC GENE CLUSTER, MECHANISM OF SELF-RESISTANCE, AND FORMATION OF URIDINE-5'-CARBOXAMIDE. The Journal of Biological Chemistry. 290: 13710-24. PMID 25855790 DOI: 10.1074/jbc.M115.646414  1
2015 Jiang L, Watkins D, Jin Y, Gong C, King A, Washington AZ, Green KD, Garneau-Tsodikova S, Oyelere AK, Arya DP. Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (PA) library. Acs Chemical Biology. 10: 1278-89. PMID 25706406 DOI: 10.1021/cb5010367  1
2015 Labby KJ, Watsula SG, Garneau-Tsodikova S. Interrupted adenylation domains: unique bifunctional enzymes involved in nonribosomal peptide biosynthesis. Natural Product Reports. 32: 641-53. PMID 25622971 DOI: 10.1039/c4np00120f  1
2015 Gajadeera C, Willby MJ, Green KD, Shaul P, Fridman M, Garneau-Tsodikova S, Posey JE, Tsodikov OV. Antimycobacterial activity of DNA intercalator inhibitors of Mycobacterium tuberculosis primase DnaG. The Journal of Antibiotics. 68: 153-7. PMID 25248725 DOI: 10.1038/ja.2014.131  1
2015 Blacher E, Ben Baruch B, Levy A, Geva N, Green KD, Garneau-Tsodikova S, Fridman M, Stein R. Inhibition of glioma progression by a newly discovered CD38 inhibitor. International Journal of Cancer. Journal International Du Cancer. 136: 1422-33. PMID 25053177 DOI: 10.1002/ijc.29095  1
2015 Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S. Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: A case of challenging structure determination at low resolution Bmc Structural Biology. 15. DOI: 10.1186/s12900-015-0040-6  1
2015 Fosso MY, LeVine H, Green KD, Tsodikov OV, Garneau-Tsodikova S. Effects of structural modifications on the metal binding, anti-amyloid activity, and cholinesterase inhibitory activity of chalcones Organic and Biomolecular Chemistry. 13: 9418-9426. DOI: 10.1039/c5ob01478f  1
2015 Assimon VA, Shao H, Garneau-Tsodikova S, Gestwicki JE. Concise synthesis of spergualin-inspired molecules with broad-spectrum antibiotic activity Medchemcomm. 6: 912-918. DOI: 10.1039/c4md00572d  1
2014 Al-Mestarihi AH, Villamizar G, Fernández J, Zolova OE, Lombó F, Garneau-Tsodikova S. Adenylation and S-methylation of cysteine by the bifunctional enzyme TioN in thiocoraline biosynthesis. Journal of the American Chemical Society. 136: 17350-4. PMID 25409494 DOI: 10.1021/ja510489j  1
2014 Fosso MY, Li Y, Garneau-Tsodikova S. New trends in aminoglycosides use. Medchemcomm. 5: 1075-1091. PMID 25071928 DOI: 10.1039/C4MD00163J  1
2014 Tsodikov OV, Green KD, Garneau-Tsodikova S. A random sequential mechanism of aminoglycoside acetylation by Mycobacterium tuberculosis Eis protein. Plos One. 9: e92370. PMID 24699000 DOI: 10.1371/journal.pone.0092370  1
2014 Zolova OE, Garneau-Tsodikova S. KtzJ-dependent serine activation and O-methylation by KtzH for kutznerides biosynthesis. The Journal of Antibiotics. 67: 59-64. PMID 24105608 DOI: 10.1038/ja.2013.98  1
2014 Garneau-Tsodikova S, Baasov T. Carbohydrates themed issue Medchemcomm. 5: 1010-1013. DOI: 10.1039/c4md90022g  1
2013 Houghton JL, Biswas T, Chen W, Tsodikov OV, Garneau-Tsodikova S. Chemical and structural insights into the regioversatility of the aminoglycoside acetyltransferase Eis. Chembiochem : a European Journal of Chemical Biology. 14: 2127-35. PMID 24106131 DOI: 10.1002/cbic.201300359  1
2013 Biswas T, Green KD, Garneau-Tsodikova S, Tsodikov OV. Discovery of inhibitors of Bacillus anthracis primase DnaG. Biochemistry. 52: 6905-10. PMID 24004110 DOI: 10.1021/bi4011286  1
2013 Green KD, Garneau-Tsodikova S. Resistance in tuberculosis: what do we know and where can we go? Frontiers in Microbiology. 4: 208. PMID 23888158 DOI: 10.3389/fmicb.2013.00208  1
2013 Labby KJ, Garneau-Tsodikova S. Strategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infections. Future Medicinal Chemistry. 5: 1285-309. PMID 23859208 DOI: 10.4155/fmc.13.80  1
2013 Jennings BC, Labby KJ, Green KD, Garneau-Tsodikova S. Redesign of substrate specificity and identification of the aminoglycoside binding residues of Eis from Mycobacterium tuberculosis. Biochemistry. 52: 5125-32. PMID 23837529 DOI: 10.1021/bi4002985  1
2013 Berkov-Zrihen Y, Green KD, Labby KJ, Feldman M, Garneau-Tsodikova S, Fridman M. Synthesis and evaluation of hetero- and homodimers of ribosome-targeting antibiotics: antimicrobial activity, in vitro inhibition of translation, and drug resistance. Journal of Medicinal Chemistry. 56: 5613-25. PMID 23786357 DOI: 10.1021/jm400707f  1
2013 Eckroat TJ, Mayhoub AS, Garneau-Tsodikova S. Amyloid-β probes: Review of structure-activity and brain-kinetics relationships. Beilstein Journal of Organic Chemistry. 9: 1012-44. PMID 23766818 DOI: 10.3762/bjoc.9.116  1
2013 Eckroat TJ, Green KD, Reed RA, Bornstein JJ, Garneau-Tsodikova S. Investigation of the role of linker moieties in bifunctional tacrine hybrids. Bioorganic & Medicinal Chemistry. 21: 3614-23. PMID 23535563 DOI: 10.1016/j.bmc.2013.02.047  1
2013 Green KD, Garneau-Tsodikova S. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6')-IId from Serratia marcescens. Biochimie. 95: 1319-25. PMID 23485681 DOI: 10.1016/j.biochi.2013.02.011  1
2013 Houghton JL, Green KD, Pricer RE, Mayhoub AS, Garneau-Tsodikova S. Unexpected N-acetylation of capreomycin by mycobacterial Eis enzymes. The Journal of Antimicrobial Chemotherapy. 68: 800-5. PMID 23233486 DOI: 10.1093/jac/dks497  1
2013 Kochi A, Eckroat TJ, Green KD, Mayhoub AS, Lim MH, Garneau-Tsodikova S. A novel hybrid of 6-chlorotacrine and metal-amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation Chemical Science. 4: 4137-4145. DOI: 10.1039/c3sc51902c  1
2012 Pricer RE, Houghton JL, Green KD, Mayhoub AS, Garneau-Tsodikova S. Biochemical and structural analysis of aminoglycoside acetyltransferase Eis from Anabaena variabilis. Molecular Biosystems. 8: 3305-13. PMID 23090428 DOI: 10.1039/c2mb25341k  1
2012 Chen W, Green KD, Garneau-Tsodikova S. Cosubstrate tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy. 56: 5831-8. PMID 22948873 DOI: 10.1128/AAC.00932-12  1
2012 Chen W, Green KD, Tsodikov OV, Garneau-Tsodikova S. Aminoglycoside multiacetylating activity of the enhanced intracellular survival protein from Mycobacterium smegmatis and its inhibition. Biochemistry. 51: 4959-67. PMID 22646013 DOI: 10.1021/bi3004473  1
2012 Herzog IM, Green KD, Berkov-Zrihen Y, Feldman M, Vidavski RR, Eldar-Boock A, Satchi-Fainaro R, Eldar A, Garneau-Tsodikova S, Fridman M. 6''-Thioether tobramycin analogues: towards selective targeting of bacterial membranes. Angewandte Chemie (International Ed. in English). 51: 5652-6. PMID 22499286 DOI: 10.1002/anie.201200761  1
2012 Biswas T, Houghton JL, Garneau-Tsodikova S, Tsodikov OV. The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI. Protein Science : a Publication of the Protein Society. 21: 520-30. PMID 22294317 DOI: 10.1002/pro.2036  1
2012 Green KD, Chen W, Garneau-Tsodikova S. Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis. Chemmedchem. 7: 73-7. PMID 21898832 DOI: 10.1002/cmdc.201100332  1
2012 Garneau-Tsodikova S, Walsh CT. Editorial: Natural products themed issue Medchemcomm. 3: 852-853. DOI: 10.1039/c2md90031a  1
2012 Zolova OE, Garneau-Tsodikova S. Importance of the MbtH-like protein TioT for production and activation of the thiocoraline adenylation domain of TioK Medchemcomm. 3: 950-955. DOI: 10.1039/c2md20131c  1
2011 Chen W, Biswas T, Porter VR, Tsodikov OV, Garneau-Tsodikova S. Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB. Proceedings of the National Academy of Sciences of the United States of America. 108: 9804-8. PMID 21628583 DOI: 10.1073/pnas.1105379108  1
2011 Green KD, Chen W, Garneau-Tsodikova S. Effects of altering aminoglycoside structures on bacterial resistance enzyme activities. Antimicrobial Agents and Chemotherapy. 55: 3207-13. PMID 21537023 DOI: 10.1128/AAC.00312-11  1
2011 Mady AS, Zolova OE, Millán MÁ, Villamizar G, de la Calle F, Lombó F, Garneau-Tsodikova S. Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster. Molecular Biosystems. 7: 1999-2011. PMID 21483938 DOI: 10.1039/c1mb05044c  1
2011 Shaul P, Green KD, Rutenberg R, Kramer M, Berkov-Zrihen Y, Breiner-Goldstein E, Garneau-Tsodikova S, Fridman M. Assessment of 6'- and 6'''-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance. Organic & Biomolecular Chemistry. 9: 4057-63. PMID 21365081 DOI: 10.1039/c0ob01133a  1
2011 Bornstein JJ, Eckroat TJ, Houghton JL, Jones CK, Green KD, Garneau-Tsodikova S. Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase Medchemcomm. 2: 406-412. DOI: 10.1039/c0md00256a  1
2010 Porter VR, Green KD, Zolova OE, Houghton JL, Garneau-Tsodikova S. Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4'). Biochemical and Biophysical Research Communications. 403: 85-90. PMID 21040710 DOI: 10.1016/j.bbrc.2010.10.119  1
2010 Zolova OE, Mady AS, Garneau-Tsodikova S. Recent developments in bisintercalator natural products. Biopolymers. 93: 777-90. PMID 20578002 DOI: 10.1002/bip.21489  1
2010 Garneau-Tsodikova S. Special series: natural products at the core of drug discovery. Biopolymers. 93: 753-4. PMID 20577997 DOI: 10.1002/bip.21497  1
2010 Green KD, Porter VR, Zhang Y, Garneau-Tsodikova S. Redesign of cosubstrate specificity and identification of important residues for substrate binding to hChAT. Biochemistry. 49: 6219-27. PMID 20560540 DOI: 10.1021/bi1007996  1
2010 Houghton JL, Green KD, Chen W, Garneau-Tsodikova S. The future of aminoglycosides: the end or renaissance? Chembiochem : a European Journal of Chemical Biology. 11: 880-902. PMID 20397253 DOI: 10.1002/cbic.200900779  1
2010 Biswas T, Zolova OE, Lombó F, de la Calle F, Salas JA, Tsodikov OV, Garneau-Tsodikova S. A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline. Journal of Molecular Biology. 397: 495-507. PMID 20122935 DOI: 10.1016/j.jmb.2010.01.053  1
2010 Green KD, Chen W, Houghton JL, Fridman M, Garneau-Tsodikova S. Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides. Chembiochem : a European Journal of Chemical Biology. 11: 119-26. PMID 19899089 DOI: 10.1002/cbic.200900584  1
2010 Verdine G, Wood T, Garneau-Tsodikova S, Leurs R, Zhang MQ, Barbas C, Bunnage M, Ecker G, Peishoff C, Rees D, Uesugi M. Meet the MedChemComm editorial board Medchemcomm. 1: 13-15. DOI: 10.1039/c0md90002h  1
2010 Green KD, Garneau-Tsodikova S. Posttranslational modification of proteins Comprehensive Natural Products Ii: Chemistry and Biology. 5: 433-468.  1
2009 Green KD, Fridman M, Garneau-Tsodikova S. hChAT: a tool for the chemoenzymatic generation of potential acetyl/butyrylcholinesterase inhibitors. Chembiochem : a European Journal of Chemical Biology. 10: 2191-4. PMID 19637146 DOI: 10.1002/cbic.200900309  1
2009 Li MH, Ung PM, Zajkowski J, Garneau-Tsodikova S, Sherman DH. Automated genome mining for natural products. Bmc Bioinformatics. 10: 185. PMID 19531248 DOI: 10.1186/1471-2105-10-185  1
2009 Garneau-Tsodikova S, Shkel IA, Tsodikov OV. Exact and user-friendly kinetic analysis of the two-step rapid equilibrium Michaelis-Menten mechanism. Analytical Biochemistry. 387: 276-9. PMID 19344659 DOI: 10.1016/j.ab.2009.01.023  1
2009 McQuade TJ, Shallop AD, Sheoran A, Delproposto JE, Tsodikov OV, Garneau-Tsodikova S. A nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis. Analytical Biochemistry. 386: 244-50. PMID 19135023 DOI: 10.1016/j.ab.2008.12.014  1
2008 Garneau-Tsodikova S, Thannickal VJ. Protein kinase inhibitors in the treatment of pulmonary fibrosis. Current Medicinal Chemistry. 15: 2632-40. PMID 18855683 DOI: 10.2174/092986708785908969  1
2008 Martin-Visscher LA, van Belkum MJ, Garneau-Tsodikova S, Whittal RM, Zheng J, McMullen LM, Vederas JC. Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Applied and Environmental Microbiology. 74: 4756-63. PMID 18552180 DOI: 10.1128/AEM.00817-08  1
2008 Sheoran A, King A, Velasco A, Pero JM, Garneau-Tsodikova S. Characterization of TioF, a tryptophan 2,3-dioxygenase involved in 3-hydroxyquinaldic acid formation during thiocoraline biosynthesis. Molecular Biosystems. 4: 622-8. PMID 18493661 DOI: 10.1039/b801391h  1
2007 Balibar CJ, Garneau-Tsodikova S, Walsh CT. Covalent CouN7 enzyme intermediate for acyl group shuttling in aminocoumarin biosynthesis. Chemistry & Biology. 14: 679-90. PMID 17584615 DOI: 10.1016/j.chembiol.2007.05.007  1
2007 Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 46: 8462-71. PMID 17580964 DOI: 10.1021/bi700433v  1
2006 Ueki M, Galoni? DP, Vaillancourt FH, Garneau-Tsodikova S, Yeh E, Vosburg DA, Schroeder FC, Osada H, Walsh CT. Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Chemistry & Biology. 13: 1183-91. PMID 17114000 DOI: 10.1016/j.chembiol.2006.09.012  1
2006 Dorrestein PC, Bumpus SB, Calderone CT, Garneau-Tsodikova S, Aron ZD, Straight PD, Kolter R, Walsh CT, Kelleher NL. Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry. 45: 12756-66. PMID 17042494 DOI: 10.1021/bi061169d  1
2006 Garneau-Tsodikova S, Dorrestein PC, Kelleher NL, Walsh CT. Protein assembly line components in prodigiosin biosynthesis: characterization of PigA,G,H,I,J. Journal of the American Chemical Society. 128: 12600-1. PMID 17002325 DOI: 10.1021/ja063611l  1
2006 Vaillancourt FH, Yeh E, Vosburg DA, Garneau-Tsodikova S, Walsh CT. Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chemical Reviews. 106: 3364-78. PMID 16895332 DOI: 10.1021/cr050313i  1
2006 Walsh CT, Garneau-Tsodikova S, Howard-Jones AR. Biological formation of pyrroles: nature's logic and enzymatic machinery. Natural Product Reports. 23: 517-31. PMID 16874387 DOI: 10.1039/b605245m  1
2006 Garneau-Tsodikova S, Stapon A, Kahne D, Walsh CT. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry. 45: 8568-78. PMID 16834331 DOI: 10.1021/bi060784e  1
2006 Dorrestein PC, Blackhall J, Straight PD, Fischbach MA, Garneau-Tsodikova S, Edwards DJ, McLaughlin S, Lin M, Gerwick WH, Kolter R, Walsh CT, Kelleher NL. Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry. 45: 1537-46. PMID 16460000 DOI: 10.1021/bi052333k  1
2005 Walsh CT, Garneau-Tsodikova S, Gatto GJ. Protein posttranslational modifications: the chemistry of proteome diversifications. Angewandte Chemie (International Ed. in English). 44: 7342-72. PMID 16267872 DOI: 10.1002/anie.200501023  1
2005 Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT. Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13843-8. PMID 16162666 DOI: 10.1073/pnas.0506964102  1
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