Leroy B. Townsend, Ph.D. - Publications

Affiliations: 
1965-1978 University of Utah, Salt Lake City, UT 
 1979-2000 University of Michigan, Ann Arbor, Ann Arbor, MI 
Website:
http://um2017.org/faculty-history/faculty/leroy-townsend/memoir

315 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Dittmer A, Woskobojnik I, Adfeldt R, Drach JC, Townsend LB, Voigt S, Bogner E. Tetrahalogenated benzimidazole D-ribonucleosides are active against rat cytomegalovirus. Antiviral Research. PMID 27871886 DOI: 10.1016/J.Antiviral.2016.11.012  0.362
2011 Prichard MN, Frederick SL, Daily S, Borysko KZ, Townsend LB, Drach JC, Kern ER. Benzimidazole analogs inhibit human herpesvirus 6. Antimicrobial Agents and Chemotherapy. 55: 2442-5. PMID 21300829 DOI: 10.1128/Aac.01523-10  0.378
2010 Frederick S, Daily S, Borysko K, Townsend L, Drach J, Prichard M. Structure–Activity Relationships of d- and L-analogs of Maribavir and 1-Beta-d-ribofuranosyl-2-bromo-5,6-dichlorobenzimidazole (bdcrb) Against Human Herpesvirus 6 Antiviral Research. 86: A54. DOI: 10.1016/J.Antiviral.2010.02.434  0.412
2010 CHENG CS, HOOPS GC, EARL RA, TOWNSEND LB. ChemInform Abstract: Synthesis of Pyrrolo(2,3-d)pyrimidines that are Structurally Related to Methylated Guanosines from tRNA and the Nucleoside Q Analogues, PreQ0 and PreQ1. Cheminform. 28: no-no. DOI: 10.1002/chin.199740270  0.323
2010 GUDMUNDSSON KS, DRACH JC, WOTRING LL, TOWNSEND LB. ChemInform Abstract: Synthesis and Antiviral Activity of Certain 5′-Modified Analogues of 2, 5,6-Trichloro-1-(β-D-ribofuranosyl)benzimidazole (TCRB). Cheminform. 28: no-no. DOI: 10.1002/chin.199723255  0.361
2010 SALLAM MAE, TOWNSEND LB, BUTLER W. ChemInform Abstract: Synthesis of 4-(2,5-Anhydro-D-galacto-pentitol-1-yl)-2-phenyl-2H-1,2,3- triazole, a homo-C-Nucleoside Analogue. Cheminform. 26: no-no. DOI: 10.1002/chin.199532213  0.368
2009 Hwang JS, Schilf R, Drach JC, Townsend LB, Bogner E. Susceptibilities of human cytomegalovirus clinical isolates and other herpesviruses to new acetylated, tetrahalogenated benzimidazole D-ribonucleosides. Antimicrobial Agents and Chemotherapy. 53: 5095-101. PMID 19786605 DOI: 10.1128/Aac.00809-09  0.356
2009 Prichard M, Frederick S, Daily S, Borysko K, Breitenbach J, Townsend L, Drach J. l-Analogs of 1-Beta-d-Ribofuranosyl-2-Bromo-5,6-Dichlorobenzimidazole (BDCRB) Inhibit Human Herpesvirus-6 Replication Antiviral Research. 82: A51. DOI: 10.1016/J.Antiviral.2009.02.117  0.383
2008 Chien TC, Drach JC, Townsend LB. Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides. Nucleic Acids Symposium Series (2004). 593-4. PMID 18776519 DOI: 10.1093/nass/nrn300  0.658
2007 Hwang JS, Kregler O, Schilf R, Bannert N, Drach JC, Townsend LB, Bogner E. Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus. Journal of Virology. 81: 11604-11. PMID 17728228 DOI: 10.1128/Jvi.01130-07  0.426
2007 HINKLEY J, BORYSKO K, BREITENBACH J, BORA K, KOSAI S, DRACH J, TOWNSEND L. Synthesis and Structure Activity Relationships among Non-nucleoside Analogs of Toyocamycin Active against Herpesviruses Antiviral Research. 74: A79-A79. DOI: 10.1016/J.Antiviral.2007.01.134  0.313
2006 Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL. N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1070-7. PMID 16565170 DOI: 10.1124/Dmd.105.009209  0.37
2005 Chien TC, Berry DA, Drach JC, Townsend LB. Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine. Nucleosides, Nucleotides & Nucleic Acids. 24: 1971-96. PMID 16438060 DOI: 10.1080/15257770500269531  0.748
2005 Williams JD, Drach JC, Townsend LB. Synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides. Nucleosides, Nucleotides & Nucleic Acids. 24: 1613-26. PMID 16438038 DOI: 10.1080/15257770500265836  0.47
2005 Chen JJ, Wei Y, Williams JD, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides. Nucleosides, Nucleotides & Nucleic Acids. 24: 1417-37. PMID 16438026 DOI: 10.1080/15257770500265646  0.475
2005 Migawa MT, Drach JC, Townsend LB. Design, synthesis and antiviral activity of novel 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d][1,2,3]triazines and the novel 3-amino-5-methyl-1-(beta-D-ribofuranosyl)- and 3-amino-5-methyl-1-(2-deoxy-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,7,8-hexaazaacenaphthylene as analogues of triciribine. Journal of Medicinal Chemistry. 48: 3840-51. PMID 15916436 DOI: 10.1021/Jm0402014  0.48
2005 Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. The Journal of Pharmacology and Experimental Therapeutics. 314: 883-90. PMID 15901797 DOI: 10.1124/Jpet.104.082412  0.34
2005 Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter. Journal of Medicinal Chemistry. 48: 1274-7. PMID 15715497 DOI: 10.1021/Jm049450I  0.371
2005 Williams JD, Kamath VP, Morris PE, Townsend LB. D‐Ribonolactone and 2,3‐Isopropylidene(D‐Ribonolactone) Organic Syntheses. 75-79. DOI: 10.1002/0471264229.Os082.12  0.401
2004 Williams JD, Ptak RG, Drach JC, Townsend LB. Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides. Journal of Medicinal Chemistry. 47: 5773-82. PMID 15509176 DOI: 10.1021/Jm0400606  0.467
2004 Williams JD, Chen JJ, Drach JC, Townsend LB. Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives. Journal of Medicinal Chemistry. 47: 5766-72. PMID 15509175 DOI: 10.1021/Jm040032N  0.469
2004 Williams JD, Chen JJ, Drach JC, Townsend LB. Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides. Journal of Medicinal Chemistry. 47: 5753-65. PMID 15509174 DOI: 10.1021/Jm0400146  0.399
2004 Chien TC, Saluja SS, Drach JC, Townsend LB. Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. Journal of Medicinal Chemistry. 47: 5743-52. PMID 15509173 DOI: 10.1021/Jm040016Q  0.681
2004 Evers DL, Komazin G, Ptak RG, Shin D, Emmer BT, Townsend LB, Drach JC. Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms. Antimicrobial Agents and Chemotherapy. 48: 3918-27. PMID 15388453 DOI: 10.1128/Aac.48.10.3918-3927.2004  0.372
2004 Chien TC, Meade EA, Hinkley JM, Townsend LB. Facile synthesis of 1-substituted 2-amino-3-cyanopyrroles: new synthetic precursors for 5,6-unsubstituted pyrrolo[2,3-d]pyrimidines. Organic Letters. 6: 2857-9. PMID 15330632 DOI: 10.1021/Ol049207D  0.651
2004 Williams JD, Drach JC, Townsend LB. Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides. Nucleosides, Nucleotides & Nucleic Acids. 23: 805-12. PMID 15281368 DOI: 10.1081/Ncn-120039253  0.378
2004 North TW, Sequar G, Townsend LB, Drach JC, Barry PA. Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides. Antimicrobial Agents and Chemotherapy. 48: 2760-5. PMID 15215146 DOI: 10.1128/Aac.48.7.2760-2765.2004  0.38
2004 Underwood MR, Ferris RG, Selleseth DW, Davis MG, Drach JC, Townsend LB, Biron KK, Boyd FL. Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus. Antimicrobial Agents and Chemotherapy. 48: 1647-51. PMID 15105116 DOI: 10.1128/Aac.48.5.1647-1651.2004  0.329
2004 Porcari AR, Townsend LB. An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. Nucleosides, Nucleotides & Nucleic Acids. 23: 31-9. PMID 15043134 DOI: 10.1081/Ncn-120027815  0.443
2004 Berry DA, Chien TC, Townsend LB. Mononuclear heterocyclic rearrangement: Synthesis of [5:5] bicyclic [c]-fused 3-aminopyrazoles via the N-N bond formation strategy Heterocycles. 63: 2475-2494. DOI: 10.3987/Com-04-10144  0.711
2004 Chien TC, Smaldone RA, Townsend LB. Facile synthesis of 1-substituted 4,5-diaminopyrazoles and its application toward the synthesis of pyrazolo[3,4-b]pyrazines Tetrahedron Letters. 45: 4105-4108. DOI: 10.1016/J.Tetlet.2004.03.142  0.658
2003 Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Drach JC, Townsend LB. Synthesis and antiviral activity of 2-substituted analogs of triciribine. Nucleosides, Nucleotides & Nucleic Acids. 22: 2171-93. PMID 14714765 DOI: 10.1081/Ncn-120026873  0.342
2003 Williams JD, Mourad AE, Drach JC, Townsend LB. Design and synthesis of acyclic nucleoside analogs with chlorinated imidazo[1,2-a]pyridine bases. Nucleosides, Nucleotides & Nucleic Acids. 22: 1907-17. PMID 14609230 DOI: 10.1081/Ncn-120025238  0.387
2003 Komazin G, Ptak RG, Emmer BT, Townsend LB, Drach JC. Resistance of human cytomegalovirus to D- and L-ribosyl benzimidazoles as a tool to identify potential targets for antiviral drugs. Nucleosides, Nucleotides & Nucleic Acids. 22: 1725-7. PMID 14565505 DOI: 10.1081/Ncn-120023123  0.301
2003 Kourafalos VN, Marakos P, Pouli N, Townsend LB. The synthesis of 4-deazaformycin A. The Journal of Organic Chemistry. 68: 6466-9. PMID 12895092 DOI: 10.1021/Jo026715X  0.497
2003 Williams SL, Hartline CB, Kushner NL, Harden EA, Bidanset DJ, Drach JC, Townsend LB, Underwood MR, Biron KK, Kern ER. In vitro activities of benzimidazole D- and L-ribonucleosides against herpesviruses. Antimicrobial Agents and Chemotherapy. 47: 2186-92. PMID 12821466 DOI: 10.1128/Aac.47.7.2186-2192.2003  0.337
2003 Chen JJ, Drach JC, Townsend LB. Convergent synthesis of polyhalogenated quinoline C-nucleosides as potential antiviral agents. The Journal of Organic Chemistry. 68: 4170-8. PMID 12762715 DOI: 10.1021/Jo020643S  0.449
2003 Gudmundsson KS, Williams JD, Drach JC, Townsend LB. Synthesis and antiviral activity of novel erythrofuranosyl imidazo[1,2-a]pyridine C-nucleosides constructed via palladium coupling of iodoimidazo[1,2-a]pyridines and dihydrofuran. Journal of Medicinal Chemistry. 46: 1449-55. PMID 12672244 DOI: 10.1021/Jm020339R  0.463
2003 Earl RA, Townsend LB. Methyl 4‐Hydroxy‐2‐Butynoate Organic Syntheses. 81-81. DOI: 10.1002/0471264180.Os060.18  0.345
2002 Evers DL, Breitenbach JM, Borysko KZ, Townsend LB, Drach JC. Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity. Antimicrobial Agents and Chemotherapy. 46: 2470-6. PMID 12121920 DOI: 10.1128/Aac.46.8.2470-2476.2002  0.373
2002 Biron KK, Harvey RJ, Chamberlain SC, Good SS, Smith AA, Davis MG, Talarico CL, Miller WH, Ferris R, Dornsife RE, Stanat SC, Drach JC, Townsend LB, Koszalka GW. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrobial Agents and Chemotherapy. 46: 2365-72. PMID 12121906 DOI: 10.1128/Aac.46.8.2365-2372.2002  0.351
2002 Krosky PM, Borysko KZ, Nassiri MR, Devivar RV, Ptak RG, Davis MG, Biron KK, Townsend LB, Drach JC. Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus. Antimicrobial Agents and Chemotherapy. 46: 478-86. PMID 11796361 DOI: 10.1128/Aac.46.2.478-486.2002  0.407
2002 Kourafalos VN, Marakos P, Pouli N, Terzis A, Townsend LB. Synthesis of 7-aminopyrazolo[3,4-c]pyridine as a probe for the preparation of compounds of pharmacological interest Heterocycles. 57: 2335-2343. DOI: 10.3987/Com-02-9621  0.41
2002 Kourafalos VN, Marakos P, Pouli N, Townsend LB. The synthesis of a new pyrazolo[3,4-c]pyridine C-nucleoside, structurally related to formycin B Synlett. 1479-1482. DOI: 10.1055/S-2002-33534  0.387
2001 Liu W, Wise DS, Townsend LB. Dimetalation of pyrazines. a one-pot synthesis of multisubstituted pyrazine C-nucleosides. The Journal of Organic Chemistry. 66: 4783-6. PMID 11442404 DOI: 10.1021/Jo001555F  0.451
2001 Migawa MT, Townsend LB. Synthesis and unusual chemical reactivity of certain novel 4,5-disubstituted 7-benzylpyrrolo[2,3-d][1,2,3]triazines. The Journal of Organic Chemistry. 66: 4776-82. PMID 11442403 DOI: 10.1021/Jo001499I  0.501
2001 Sallam MA, Abdel Megid SM, Townsend LB. Acid-catalyzed dehydrative cyclization of 4-(D-galacto -pentitol-1-yl)-2-phenyl-2H-1,2,3-triazole. synthesis and anomeric configuration of D-lyxo-C-nucleoside analogs. Carbohydrate Research. 330: 53-63. PMID 11217962 DOI: 10.1016/S0008-6215(00)00251-2  0.444
2000 Gudmundsson KS, Freeman GA, Drach JC, Townsend LB. Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability. Journal of Medicinal Chemistry. 43: 2473-8. PMID 10882375 DOI: 10.1021/Jm990219S  0.454
2000 Gudmundsson KS, Tidwell J, Lippa N, Koszalka GW, van Draanen N, Ptak RG, Drach JC, Townsend LB. Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles. Journal of Medicinal Chemistry. 43: 2464-72. PMID 10882374 DOI: 10.1021/jm990195p  0.363
2000 Chen JJ, Wei Y, Drach JC, Townsend LB. Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB). Journal of Medicinal Chemistry. 43: 2449-56. PMID 10882372 DOI: 10.1021/Jm990320X  0.466
2000 Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Vittori S, Wotring LL, Drach JC, Townsend LB. Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation. Journal of Medicinal Chemistry. 43: 2438-48. PMID 10882371 DOI: 10.1021/Jm990205M  0.304
2000 Zhu Z, Lippa B, Drach JC, Townsend LB. Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides. Journal of Medicinal Chemistry. 43: 2430-7. PMID 10882370 DOI: 10.1021/Jm990290Y  0.468
2000 Zou R, Kawashima E, Freeman GA, Koszalka GW, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluation of 2-deoxy-D-ribosides of substituted benzimidazoles as potential agents for human cytomegalovirus infections. Nucleosides, Nucleotides & Nucleic Acids. 19: 125-53. PMID 10772706 DOI: 10.1080/15257770008033000  0.503
2000 Krawczyk S, Migawa MT, Drach JC, Townsend LB. Synthesis of 4-substituted imidazo[4,5-d][1,2,3]triazine (2-azapurine)nucleosides. Nucleosides, Nucleotides & Nucleic Acids. 19: 39-68. PMID 10772702 DOI: 10.1080/15257770008032996  0.485
2000 Gudmundsson KS, Freeman GA, Drach JC, Townsend LB. ChemInform Abstract: Synthesis of Fluorosugar Analogues of 2,5,6-Trichloro-1-(β-D-ribofuranosyl)benzimidazole as Antivirals with Potentially Increased Glycosidic Bond Stability. Cheminform. 31: no-no. DOI: 10.1002/chin.200040197  0.304
1999 Migawa MT, Townsend LB. An unprecedented nitrogen elimination reaction: mechanistic studies using 15N-labeled 4-amino-7-benzylpyrrolo[2,3-d][1,2,3]triazine-5-carbonitrile. Organic Letters. 1: 537-9. PMID 10823187 DOI: 10.1021/Ol990006X  0.348
1999 Townsend LB, Gudmundsson KS, Daluge SM, Chen JJ, Zhu Z, Koszalka GW, Boyd L, Chamberlain SD, Freeman GA, Biron KK, Drach JC. Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB. Nucleosides & Nucleotides. 18: 509-19. PMID 10432642 DOI: 10.1080/15257779908041486  0.33
1999 Jacobson JG, Renau TE, Nassiri MR, Sweier DG, Breitenbach JM, Townsend LB, Drach JC. Nonnucleoside pyrrolopyrimidines with a unique mechanism of action against human cytomegalovirus. Antimicrobial Agents and Chemotherapy. 43: 1888-94. PMID 10428908 DOI: 10.1128/Aac.43.8.1888  0.33
1999 Porcari AR, Townsend LB. Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures. Nucleosides & Nucleotides. 18: 153-9. PMID 10067270 DOI: 10.1080/15257779908043063  0.355
1999 Panzica RP, Townsend LB. Analogs of AICA- and ISOAICA ribosides and their methylated base counterparts Nucleosides and Nucleotides. 18: 2345-2356. DOI: 10.1080/07328319908044611  0.37
1999 Migawa MT, Townsend LB. An efficient synthesis of 2-nitropyrrole-3,4-dicarboxamide Synthetic Communications. 29: 3757-3772. DOI: 10.1080/00397919908086015  0.407
1999 Zhu Z, Lippa B, Townsend LB. Synthesis and regioselective ribosylation of 6,7-dichloroimidazo[4,5- b]quinolin-2-one Journal of Organic Chemistry. 64: 4159-4168. DOI: 10.1021/Jo982084O  0.438
1999 Girardet JL, Townsend LB. Synthesis of β-L-lyxofuranosyl benzimidazoles by an unexpected intramolecular displacement reaction Journal of Organic Chemistry. 64: 4169-4172. DOI: 10.1021/Jo981733T  0.322
1998 Migawa MT, Girardet JL, Walker JA, Koszalka GW, Chamberlain SD, Drach JC, Townsend LB. Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles. Journal of Medicinal Chemistry. 41: 1242-51. PMID 9575044 DOI: 10.1021/Jm970545C  0.396
1998 Porcari AR, Devivar RV, Kucera LS, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles as nonnucleoside analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. Journal of Medicinal Chemistry. 41: 1252-62. PMID 9548815 DOI: 10.1021/Jm970559I  0.384
1998 Walker JA, Liu W, Wise DS, Drach JC, Townsend LB. Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides. Journal of Medicinal Chemistry. 41: 1236-41. PMID 9548814 DOI: 10.1021/Jm970532Z  0.455
1998 Underwood MR, Harvey RJ, Stanat SC, Hemphill ML, Miller T, Drach JC, Townsend LB, Biron KK. Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product. Journal of Virology. 72: 717-25. PMID 9420278 DOI: 10.1128/Jvi.72.1.717-725.1998  0.306
1998 Girardet JL, Drach JC, Chamberlain SD, Koszalka GW, Townsend LB. Design, synthesis and antiviral activity of α-L-arabinofuranosyl derivatives of 2-substituted-5,6-dichlorobenzimidazoles Nucleosides and Nucleotides. 17: 2389-2401. DOI: 10.1080/07328319808004326  0.359
1998 Sallam MAE, Townsend LB. Homo-C-nucleoside analogs II. Synthesis and anomeric configuration of 4- (2,5-anhydro-D-glucopentitol-1-yl)-2-phenyl-2H-1,2,3-triazole Nucleosides and Nucleotides. 17: 1215-1229. DOI: 10.1080/07328319808004234  0.44
1998 Porcari AR, Townsend LB. An improved synthesis of the versatile heterocycle, 4-amino-6-bromo-5- cyanopyrrolo [2,3-d]pyrimidine Synthetic Communications. 28: 3835-3843. DOI: 10.1080/00397919808004937  0.426
1998 Zhu Z, Drach JC, Townsend LB. Synthesis of 2,6,7-Trichloro-1-(β-D-ribofuranosyl)naphtho[2,3-d]imidazole: A Linear Dimensional Analogue of the Antiviral Agent TCRB Journal of Organic Chemistry. 63: 977-983. DOI: 10.1021/Jo971152O  0.458
1998 Gudmundsson KS, Drach JC, Townsend LB. Synthesis of the First C3 Ribosylated Imidazo[1,2-a]pyridine C-Nucleoside by Enantioselective Construction of the Ribose Moiety Journal of Organic Chemistry. 63: 984-989. DOI: 10.1021/Jo9711145  0.411
1998 Zhu Z, Saluja S, Drach JC, Townsend LB. Synthesis of Imidazo[4,5-b]quinoxaline Ribonucleosides as Linear Dimensional Analogs of Antiviral Polyhalogenated Benzimidazole Ribonucleosides Journal of the Chinese Chemical Society. 45: 465-474. DOI: 10.1002/Jccs.199800071  0.398
1997 Zou R, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 40: 811-8. PMID 9057868 DOI: 10.1021/Jm960462G  0.406
1997 Zou R, Drach JC, Townsend LB. Design, synthesis, and antiviral evaluation of 2-substituted 4,5-dichloro- and 4,6-dichloro-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 40: 802-10. PMID 9057867 DOI: 10.1021/Jm960533B  0.386
1997 Meade EA, Wotring LL, Drach JC, Townsend LB. Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides. Journal of Medicinal Chemistry. 40: 794-801. PMID 9057866 DOI: 10.1021/Jm960631X  0.496
1997 Gudmundsson KS, Drach JC, Wotring LL, Townsend LB. Synthesis and antiviral activity of certain 5'-modified analogs of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. Journal of Medicinal Chemistry. 40: 785-93. PMID 9057865 DOI: 10.1021/Jm9604888  0.431
1997 Swayze EE, Drach JC, Wotring LL, Townsend LB. Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside. Journal of Medicinal Chemistry. 40: 771-84. PMID 9057864 DOI: 10.1021/Jm960605Z  0.506
1997 Thompson MD, Cupps TL, Wise DS, Wotring LL, Townsend LB. Synthesis and evaluation of 6-(dibromomethyl)-5-nitropyrimidines as potential antitumor agents. Journal of Medicinal Chemistry. 40: 766-70. PMID 9057863 DOI: 10.1021/Jm9605546  0.307
1997 Walker JA, Chen JJ, Hinkley JM, Wise DS, Townsend LB. Novel 2'-deoxy pyrazine C-nucleosides synthesized via palladium- catalyzed cross-couplings Nucleosides and Nucleotides. 16: 1999-2012. DOI: 10.1080/07328319708002550  0.483
1997 Cheng CS, Hoops GC, Earl RA, Townsend LB. Synthesis of pyrrolo[2,3-rf]pyrimidines that are structurally related to methylated guanosines from trna and the nucleoside q analogs, preq0 and preql Nucleosides and Nucleotides. 16: 347-364. DOI: 10.1080/07328319708001355  0.461
1997 Gudmundsson KS, Hinkley JM, Brieger MS, Drach JC, Townsend LB. An improved large scale synthesis of 2-amino-4-chloropyridine and its use for the convenient preparation of various polychlorinated 2-aminopyridines Synthetic Communications. 27: 861-870. DOI: 10.1080/00397919708004207  0.349
1997 Gudmundsson KS, Drach JC, Townsend LB. An improved synthesis of 2-chlorinated imidazo[1,2-a]pyridines and the application of this procedure for the synthesis of several new polychlorinated imidazo[1,2-a]pyridines Synthetic Communications. 27: 1763-1775. DOI: 10.1080/00397919708004089  0.36
1997 Marakos P, Pouli N, Wise DS, Townsend LB. A new and facile method for the preparation of 3-substituted pyrazolo[3,4-c]pyridines Synlett. 561-562. DOI: 10.1055/S-1997-3211  0.329
1997 Gudmundsson KS, Drach JC, Townsend LB. Synthesis of imidazo[1,2-a]pyridine C-nucleosides with an unexpected site of ribosylation Journal of Organic Chemistry. 62: 3453-3459. DOI: 10.1021/Jo9619342  0.423
1996 Zou R, Ayres KR, Drach JC, Townsend LB. Synthesis and antiviral evaluation of certain disubstituted benzimidazole ribonucleosides. Journal of Medicinal Chemistry. 39: 3477-82. PMID 8784445 DOI: 10.1021/Jm960157V  0.486
1996 Renau TE, Kennedy C, Ptak RG, Breitenbach JM, Drach JC, Townsend LB. Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 39: 3470-6. PMID 8784444 DOI: 10.1021/Jm950835Y  0.474
1996 Nassiri MR, Emerson SG, Devivar RV, Townsend LB, Drach JC, Taichman RS. Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells. British Journal of Haematology. 93: 273-9. PMID 8639416 DOI: 10.1046/J.1365-2141.1996.5231066.X  0.323
1996 Saluja S, Zou R, Drach JC, Townsend LB. Structure-activity relationships among 2-substituted 5,6-dichloro-, 4,6-dichloro-, and 4,5-dichloro-1-[(2-hydroxyethoxy) methyl]- and -1-[(1,3-dihydroxy-2-propoxy) methyl]benzimidazoles. Journal of Medicinal Chemistry. 39: 881-91. PMID 8632412 DOI: 10.1021/Jm950556A  0.428
1996 Renau TE, Wotring LL, Drach JC, Townsend LB. Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity. Journal of Medicinal Chemistry. 39: 873-80. PMID 8632411 DOI: 10.1021/Jm950444J  0.415
1996 Hsu LY, Wise DS, Drach JC, Townsend LB. Synthesis of 1-hydroxy-10-methyl-pyrimido [1,6-C][1,3]oxazine and the oxazepine derivative, structural mimicry of anti-constrained acyclic thymidine Nucleosides and Nucleotides. 15: 1481-1493. DOI: 10.1080/07328319608002449  0.341
1996 Groziak MP, Lin R, Stevens WC, Wotring LL, Townsend LB, Balzarini J, Witvrouw M, De Clercq E. Definitive solution structures for the 6-formylated versions of 1-(β-D-ribofuranosyl)-, 1-(2′-deoxy-β-D-ribofuranosyl)-, and 1-β-D-arabinofuranosyluracil, and of thymidine Nucleosides and Nucleotides. 15: 1041-1057. DOI: 10.1080/07328319608002033  0.412
1996 Migawa MT, Hinkley JM, Hoops GC, Townsend LB. A two step synthesis of the nucleoside Q precursor 2-amino-5-cyanopyrrolo[2,3-d]pyrimidin-4-one (preQ(o)) Synthetic Communications. 26: 3317-3322. DOI: 10.1080/00397919608004641  0.435
1996 Chen JJ, Hinkley JM, Wise DS, Townsend LB. Application of the curtius rearrangement in a convenient preparation of 3-amino -pyrazinecarboxylic acid, methyl ester Synthetic Communications. 26: 617-622. DOI: 10.1080/00397919608003656  0.347
1996 Walker JA, Chen JJ, Wise DS, Townsend LB. A facile, multigram synthesis of ribofuranoid glycals Journal of Organic Chemistry. 61: 2219-2221. DOI: 10.1021/Jo951376B  0.364
1996 Chen JJ, Wise DS, Townsend LB. Pyrido[2,3-b]pyrazines from pyrazine C-nucleosides: An unusual intramolecular rearrangement Journal of the American Chemical Society. 118: 8953-8954. DOI: 10.1021/Ja961315A  0.309
1996 Gudmundsson KS, Drach JC, Townsend LB. Palladium catalyzed coupling of 2,6-dichloro-3-iodoimidazo[1,2-a]pyridine and 2,3-dihydrofuran as an approach to novel imidazo[1,2-a]pyridine C-nucleosides Tetrahedron Letters. 37: 6275-6278. DOI: 10.1016/0040-4039(96)01375-5  0.363
1996 Liu W, Walker JA, Chen JJ, Wise DS, Townsend LB. Synthesis of pyrazine C-ribosides via direct metalation Tetrahedron Letters. 37: 5325-5328. DOI: 10.1016/0040-4039(96)01121-5  0.34
1996 Zhu Z, Townsend LB. Regioselective ribosylation of 6,7-dichloroimidazo[4,5-b]quinolin-2-one Tetrahedron Letters. 37: 3263-3266. DOI: 10.1016/0040-4039(96)00529-1  0.37
1996 Zhu Z, Lippa BS, Townsend LB. A novel photo-assisted annulation reaction for the synthesis of 6,7-dichloroimidazo[4,5-b]quinolin-2-one Tetrahedron Letters. 37: 1937-1940. DOI: 10.1016/0040-4039(96)00308-5  0.345
1996 Gudmundsson KS, Drach JC, Townsend LB. The condensation of 2,6-dichloroimidazo[1,2-a]pyridine with ribonolactone gives a novel imidazo[1,2-a]pyridine C-nucleoside with an unexpected site of ribosylation Tetrahedron Letters. 37: 2365-2368. DOI: 10.1016/0040-4039(96)00292-4  0.396
1996 Hoops GC, Park J, Garcia GA, Townsend LB. The synthesis and determination of acidic ionization constants of certain 5‐substituted 2‐aminopyrrolo[2,3‐ d ]pyrimidin‐4‐ones and methylated analogs Journal of Heterocyclic Chemistry. 33: 767-781. DOI: 10.1002/Jhet.5570330341  0.441
1996 Hoops GC, Park J, Garcia GA, Townsend LB. The synthesis and determination of acidic ionization constants of certain 5-substituted 2-aminopyrrolo[2,3-d]pyrimidin-4-ones and methylated analogs Journal of Heterocyclic Chemistry. 33: 767-781.  0.36
1995 Hoops GC, Townsend LB, Garcia GA. tRNA-guanine transglycosylase from Escherichia coli: structure-activity studies investigating the role of the aminomethyl substituent of the heterocyclic substrate PreQ1. Biochemistry. 34: 15381-7. PMID 7578154 DOI: 10.1021/Bi00046A047  0.36
1995 Krawczyk SH, Renau TE, Nassiri MR, Westerman AC, Wotring LL, Drach JC, Townsend LB. Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus. Journal of Medicinal Chemistry. 38: 4115-9. PMID 7562947 DOI: 10.1021/Jm00020A027  0.396
1995 Townsend LB, Devivar RV, Turk SR, Nassiri MR, Drach JC. Design, synthesis, and antiviral activity of certain 2,5,6-trihalo-1-(beta-D-ribofuranosyl)benzimidazoles. Journal of Medicinal Chemistry. 38: 4098-105. PMID 7562945 DOI: 10.1021/Jm00020A025  0.404
1995 Hoops GC, Townsend LB, Garcia GA. Mechanism-based inactivation of tRNA-guanine transglycosylase from Escherichia coli by 2-amino-5-(fluoromethyl)pyrrolo[2,3-d]pyrimidin-4 (3H)-one. Biochemistry. 34: 15539-44. PMID 7492556 DOI: 10.1021/Bi00047A020  0.384
1995 Swayze EE, Townsend LB. The synthesis of substituted imidazo[4,5-d]isothiazoles via the ring annulation of isothiazole diamines: An investigation of the chemical, physical, and biological properties of several novel 5:5 fused analogs of the purine ring system Journal of Organic Chemistry. 60: 6309-6317. DOI: 10.1021/Jo00125A016  0.43
1995 Chen JJ, Walker JA, Liu W, Wise DS, Townsend LB. An efficient and stereospecific synthesis of novel pyrazine cnucleosides Tetrahedron Letters. 36: 8363-8366. DOI: 10.1016/0040-4039(95)01826-4  0.395
1994 Renau TE, Lee JS, Kim H, Young CG, Wotring LL, Townsend LB, Drach JC. Relationship between cytotoxicity and conversion of thiosangivamycin analogs to toyocamycin analogs in cell culture medium. Biochemical Pharmacology. 48: 801-7. PMID 8080454 DOI: 10.1016/0006-2952(94)90059-0  0.352
1994 Devivar RV, Kawashima E, Revankar GR, Breitenbach JM, Kreske ED, Drach JC, Townsend LB. Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles. Journal of Medicinal Chemistry. 37: 2942-9. PMID 8071942 DOI: 10.1021/Jm00044A015  0.402
1994 Hsu LY, Wise DS, Shannon WM, Drach JC, Townsend LB. Synthesis of C-6 pyrimidine acyclic nucleoside analogs as potential antiviral agents Nucleosides and Nucleotides. 13: 563-584. DOI: 10.1080/15257779408013263  0.433
1994 Kasnar B, Wise DS, Kucera LS, Drach JC, Townsend LB. Synthesis of 2',3'-dideoxy- and 3'-azido-2',3'-dideoxy-pyridazine nucleosides as potential antiviral agents Nucleosides and Nucleotides. 13: 459-479. DOI: 10.1080/15257779408013255  0.492
1994 Berry DA, Wotring LL, Drach JC, Townsend LB. Synthesis and biological activity of the novel adenosine analogs; 3- amino-6-(β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole and 3-amino-1-methyl-6- (β-D-ribofuranosyl)pyrazolo[3,4-c]pyrazole Nucleosides and Nucleotides. 13: 405-420. DOI: 10.1080/15257779408013250  0.623
1994 Kobe J, Prhavc M, Hohnjec M, Townsend LB. Preparation and utility of 5-β3-D-ribofuranosyl-lh-tetrazole as a key synthon for C-nucleoside synthesis Nucleosides and Nucleotides. 13: 2209-2244. DOI: 10.1080/15257779408013218  0.458
1994 Berry DA, Wotring LL, Drach JC, Townsend LB. Synthesis and biological activity of 4-amino-L-(B-D-Ribofuranosyl)imidazo[4,5-TF]pyridazin-7-one Nucleosides and Nucleotides. 13: 2001-2011. DOI: 10.1080/15257779408010678  0.623
1994 Chem J, Wise D, Shewach D, Daddona P, Townsend L. Certain 8-amino-9-(benzyl)guanines as potential purine nucleoside phosphorylase inhibitors European Journal of Medicinal Chemistry. 29: 3-9. DOI: 10.1016/0223-5234(94)90119-8  0.408
1993 Chern JW, Lee HY, Chen CS, Shewach DS, Daddona PE, Townsend LB. Nucleosides. 5. Synthesis of guanine and formycin B derivatives as potential inhibitors of purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 36: 1024-31. PMID 8478902 DOI: 10.1021/Jm00060A010  0.382
1993 Kumar Y, Green R, Wise DS, Wotring LL, Townsend LB. Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antifilarial and antitumor agents. 2. 2-Arylamido and 2-alkylamido derivatives of 2-amino-4-(isothiocyanatomethyl)thiazole and 2-amino-4-(isothiocyanatomethyl)selenazole. Journal of Medicinal Chemistry. 36: 3849-52. PMID 8254615 DOI: 10.1021/Jm00076A013  0.375
1993 Kumar Y, Green R, Borysko KZ, Wise DS, Wotring LL, Townsend LB. Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4-(isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2- carbamates, and related derivatives. Journal of Medicinal Chemistry. 36: 3843-8. PMID 8254614 DOI: 10.1021/Jm00076A012  0.375
1993 Meade EA, Wotring LL, Drach JC, Townsend LB. Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives. Journal of Medicinal Chemistry. 36: 3834-42. PMID 8254613 DOI: 10.1021/Jm00076A011  0.466
1993 Swayze EE, Peiris SM, Kucera LS, White EL, Wise DS, Drach JC, Townsend LB. Synthesis of 1-(2-aminopropyl)benzimidazoles, structurally related to the TIBO derivative R82150, with activity against human immunodeficiency virus Bioorganic and Medicinal Chemistry Letters. 3: 543-546. DOI: 10.1016/S0960-894X(01)81224-5  0.311
1993 Swayze EE, Townsend LB. The synthesis of several imidazo[4,5-d]isothiazoles. Derivatives of a new ring system Journal of Heterocyclic Chemistry. 30: 1379-1383. DOI: 10.1002/Jhet.5570300533  0.466
1993 Mourad AE, Wise DS, Townsend LB. Synthesis of imidazo[1,2-b]pyridazines: Fenbendazole, oxifenbendazole analogs and related derivatives Journal of Heterocyclic Chemistry. 30: 1365-1372. DOI: 10.1002/Jhet.5570300531  0.341
1992 Ram S, Wise DS, Wotring LL, McCall JW, Townsend LB. Synthesis and biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates and related derivatives: a new class of potential antineoplastic and antifilarial agents. Journal of Medicinal Chemistry. 35: 539-47. PMID 1738146 DOI: 10.1021/Jm00081A016  0.384
1992 Shewach DS, Krawczyk SH, Acevedo OL, Townsend LB. Inhibition of adenosine deaminase by azapurine ribonucleosides. Biochemical Pharmacology. 44: 1697-700. PMID 1449528 DOI: 10.1016/0006-2952(92)90061-M  0.307
1992 Renau TE, Nassiri MR, Swayze EE, Kern ER, Townsend LB, Drach JC. Improved synthesis and biological evaluation of an acyclic thiosangivamycin active against human cytomegalovirus. Antiviral Research. 19: 15-28. PMID 1332597 DOI: 10.1016/0166-3542(92)90053-8  0.382
1992 Meade EA, Wotring LL, Drach JC, Townsend LB. Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues. Journal of Medicinal Chemistry. 35: 526-33. PMID 1310744 DOI: 10.1021/Jm00081A014  0.492
1992 Pudlo JS, Townsend LB. The synthesis of novel carbohydrates amenable to the synthesis of 2',3',-dideoxy-3'-branched nucleosides Nucleosides and Nucleotides. 11: 279-293. DOI: 10.1080/07328319208021703  0.416
1992 Swayze EE, Shannon WM, Buckheit RW, Wotring LL, Drach JC, Townsend LB. Synthesis, antiproliferative, and antiviral evaluation of certain acyclic 6-substituted pyrrolo [2,3-D]-pyrimidine nucleoside analogs related to sangivamycin and toyocamycin Nucleosides and Nucleotides. 11: 1507-1527. DOI: 10.1080/07328319208021192  0.503
1992 Hsu LY, Wise DS, Kucera LS, Drach JC, Townsend LB. Synthesis of anti-restricted pyrimidine acyclic nucleosides Journal of Organic Chemistry. 57: 3354-3358. DOI: 10.1021/Jo00038A025  0.372
1992 Renau TE, Ludwig MS, Drach JC, Townsend LB. Design, synthesis and activity against human cytomegalovirus of non-phosphorylatable analogs of toyocamycin, sangivamycin and thiosangivamycin Bioorganic and Medicinal Chemistry Letters. 2: 1755-1760. DOI: 10.1016/S0960-894X(00)80470-9  0.414
1992 Mourad AE, Wise DS, Townsend LB. Methyl imidazo[1,2-b]pyridazine-2-carbamates and related compounds as potential antifilarial agents Journal of Heterocyclic Chemistry. 29: 1583-1592. DOI: 10.1002/Jhet.5570290636  0.357
1991 Zou RM, Beylin VG, Groziak MP, Wotring LL, Townsend LB. Synthetic approaches to the guanosine and xanthosine analogues 5-amino-3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazin-7-one and 3-beta-D-ribofuranosylpyrazolo[3,4-e][1,3]oxazine-5,7-dione and studies of their antitumor potential. Journal of Medicinal Chemistry. 34: 1951-9. PMID 2066967 DOI: 10.1021/Jm00111A005  0.424
1991 Nassiri MR, Turk SR, Birch GM, Coleman LA, Hudson JL, Pudlo JS, Townsend LB, Drach JC. Activity of acyclic halogenated tubercidin analogs against human cytomegalovirus and in uninfected cells. Antiviral Research. 16: 135-50. PMID 1665958 DOI: 10.1016/0166-3542(91)90020-R  0.373
1991 Prhavc M, Townsend LB, Kobe J. Reactions of 5-β-D-ribofuranosyl tetrazoles with dipolarophiles Nucleosides and Nucleotides. 10: 729-730. DOI: 10.1080/07328319108046584  0.417
1991 Chern JW, Lin GS, Chen CS, Townsend LB. Nucleosides. 3. Reactions of AICA-riboside with isothiocyanates. A convenient synthesis of isoguanosine and xanthosine derivatives Journal of Organic Chemistry. 56: 4213-4218. DOI: 10.1021/Jo00013A026  0.463
1991 Meade EA, Townsend LB. Synthesis of 4-Amino-1-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyridazine; an entry into a novel series of adenosine analogs Bioorganic and Medicinal Chemistry Letters. 1: 111-114. DOI: 10.1016/S0960-894X(00)80242-5  0.483
1991 Krawczyk SH, Townsend LB. Synthesis of a pyrido[1,2-a]purine nucleoside by a novel ring cleavage-annulation reaction of 3-β-D-ribofuranosylimidazo-[4,5-d]-v-triazin-4-one Tetrahedron Letters. 32: 5693-5696. DOI: 10.1016/S0040-4039(00)93532-9  0.434
1991 Renau T, Nassiri M, Coleman L, S.R T, Lopatin D, Swayze E, Townsend L, Drach J. Synthesis and biological evaluation of an acyclic thiosangivamycin Antiviral Research. 15: 47. DOI: 10.1016/0166-3542(91)90092-6  0.33
1991 Kawasaki AM, Townsend LB. Synthesis of 8-amino-4-methylthio-6-methyl-2-(β-D-ribofuranosyl)-2,6-dihydro-1,2,3 ,5,6,7-hexaazaacenaphthylene and an unusual reductive ring-opening of the 1,2,3,5,6,7-Hexaazaacenaphgthylene ring system Journal of Heterocyclic Chemistry. 28: 1-5. DOI: 10.1002/Jhet.5570280101  0.47
1990 Townsend LB, Wise DS. The synthesis and chemistry of certain anthelmintic benzimidazoles. Parasitology Today (Personal Ed.). 6: 107-12. PMID 15463311 DOI: 10.1016/0169-4758(90)90226-T  0.364
1990 Kawasaki AM, Wotring LL, Townsend LB. Synthesis and cytotoxicity studies of 8-amino-6-methyl-2-beta-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthyle ne (7-aza-TCN) and the corresponding 2'-deoxy- and arabinonucleoside analogues. Journal of Medicinal Chemistry. 33: 3170-6. PMID 2258902 DOI: 10.1021/Jm00174A012  0.456
1990 Krawczyk SH, Bernier-Rodriguez M, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB. Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 33: 3160-9. PMID 2175356 DOI: 10.1021/Jm00174A011  0.395
1990 Pudlo JS, Nassiri MR, Kern ER, Wotring LL, Drach JC, Townsend LB. Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 33: 1984-92. PMID 2163454 DOI: 10.1021/Jm00169A028  0.473
1990 Saxena NK, Coleman LA, Drach JC, Townsend LB. Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin. Journal of Medicinal Chemistry. 33: 1980-3. PMID 2163453 DOI: 10.1021/Jm00169A027  0.476
1990 Van Sickle A, Kawasaki AM, Townsend LB. The synthesis of 8-amino-6-N-methyl-1,2,3,5,6,7-hexaazaacenaphthylene Heterocycles. 30: 963-969. DOI: 10.3987/Com-89-S95  0.398
1990 Gupta PK, Vittori S, Townsend LB. An unexpected nucleophilic displacement involving 6-bromo-4-chloro-5-cyanopyrrolo[2,3-d]pyrimidine with methanolic ammonia Nucleosides and Nucleotides. 9: 35-41. DOI: 10.1080/07328319008045107  0.461
1990 Pudlo JS, Townsend LB. A new and novel approach towards the synthesis of 3′-deoxy-3′-hydroxymethyl ribofuosides Tetrahedron Letters. 31: 3101-3104. DOI: 10.1016/S0040-4039(00)94705-1  0.466
1989 Gupta PK, Daunert S, Nassiri MR, Wotring LL, Drach JC, Townsend LB. Synthesis, cytotoxicity, and antiviral activity of some acyclic analogues of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin Journal of Medicinal Chemistry. 32: 402-408. PMID 2913300 DOI: 10.1021/Jm00122A019  0.465
1989 Gupta PK, Nassiri MR, Coleman LA, Wotring LL, Drach JC, Townsend LB. Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin Journal of Medicinal Chemistry. 32: 1420-1425. PMID 2500527 DOI: 10.1021/Jm00127A003  0.496
1989 Alderweireldt FC, Wotring LL, Balzarini J, Vrijens I, Townsend LB, De Clercq E, Esmans EL. synthesis and biological evaluation of 2-carbamoyl-5-D-ribofuranosylpyridine Nucleosides and Nucleotides. 8: 891-894. DOI: 10.1080/07328318908054238  0.467
1989 Jankowski AJ, Wise DS, Townsend LB. Sodium Th1Osulfate and Potassium Selenosulfate as Reagents to Prepare Thio- and Selenopur1Ne Nucleosides Nucleosides and Nucleotides. 8: 339-348. DOI: 10.1080/07328318908054179  0.393
1989 Belmans M, Vrijens I, Esman EL, Dommisse RA, Lepoivre JA, Alderweireldt FC, Townsend LB, Wotring LL, Balzarini J, clercq ED. Synthesis and Biological Evaluation of a Series of Substituted Pyridine-C-Nucleosides. PART V:3-chloro-4-(d-ribofuranosyl)pyridineAnd3-(d-ribofuranosyl)-2-pyridone Nucleosides and Nucleotides. 8: 307-315. DOI: 10.1080/07328318908054176  0.503
1989 Krawczyk SH, Townsend LB. 2’,3‘-Dideoxyadenosine Analogs of the Nucleoside Antibiotics Tubercidin, Toyocamycin and Sangivamycin Nucleosides and Nucleotides. 8: 97-115. DOI: 10.1080/07328318908054160  0.35
1989 Ram S, Evans W, Wise DS, Townsend LB, McCall JW. Synthesis of potential antifilarial agents 2. Methyl 2-substituted purine 8-carbamates and related compounds Journal of Heterocyclic Chemistry. 26: 1053-1059. DOI: 10.1002/Jhet.5570260427  0.391
1989 CHERN J, LEE H, WISE DS, TOWNSEND LB. ChemInform Abstract: Synthesis of Methyl 9-Benzylguanine-8-carbamate: A Convenient Synthesis of Oxazolo(5,4-d)pyrimidines and Their Conversion into Imidazo(4,5-d)pyrimidines via a Carbodiimide-Mediated Rearrangement. Cheminform. 20. DOI: 10.1002/chin.198920209  0.402
1988 Pudlo JS, Saxena NK, Nassiri MR, Turk SR, Drach JC, Townsend LB. Synthesis and antiviral activity of certain 4- and 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines Journal of Medicinal Chemistry. 31: 2086-2092. PMID 2846837 DOI: 10.1021/Jm00119A006  0.461
1988 Saxena NK, Hagenow BM, Genzlinger G, Turk SR, Drach JC, Townsend LB. Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines Journal of Medicinal Chemistry. 31: 1501-1506. PMID 2840500 DOI: 10.1021/Jm00403A005  0.49
1988 Chern JW, Wise DS, Butler W, Townsend LB. Synthesis of 5-substituted uracils, uridines and 2'-deoxyuridine analogs Journal of Organic Chemistry. 53: 5622-5628. DOI: 10.1021/Jo00259A005  0.42
1988 Chern JW, Lee HY, Wise DS, Townsend LB. Synthesis of methyl 9-benzylguanine-8-carbamate: A convenient synthesis of oxazolo[5,4-d]pyrimidines and their conversion into imidazo[4,5-d]pyrimidines via a carbodiimide-mediated rearrangement Journal of Organic Chemistry. 53: 5617-5622. DOI: 10.1021/Jo00259A004  0.45
1988 Meade EA, Krawczyk SH, Townsend LB. A total synthesis of the naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A Tetrahedron Letters. 29: 4073-4076. DOI: 10.1016/S0040-4039(00)80420-7  0.489
1988 Beylin VG, Townsend LB. Synthesis of certain 3,5,7‐disubstituted pyrazolo[3,4‐ e ][1,3]oxazines. Derivatives of a new heterocyclic ring system Journal of Heterocyclic Chemistry. 25: 97-107. DOI: 10.1002/Jhet.5570250114  0.362
1988 Chern JW, Wise DS, Butler W, Townsend LB. Synthesis of 5-substituted uracils, uridines, and 2′-deoxyuridine analogues Journal of Organic Chemistry. 53: 5622-5628.  0.318
1987 Turk SR, Shipman C, Nassiri R, Genzlinger G, Krawczyk SH, Townsend LB, Drach JC. Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antimicrobial Agents and Chemotherapy. 31: 544-50. PMID 3037998 DOI: 10.1128/Aac.31.4.544  0.359
1987 Kobe J, Prhavc M, Hohnjec M, Townsend LB. The Preparation and Utility of 5-β-D-Ribofuranosyl-(2H)-Tetrazole as a Key Synthon for C-Nucleoside Chemistry Nucleosides and Nucleotides. 6: 365-368. DOI: 10.1080/07328318708056222  0.45
1987 Belmans M, Vrijens I, Esmans EL, Lepoivre JA, Alderweireldt FC, Wotring LL, Townsend LB. Synthesis and Biological Evaluation of 3-Chloro-4-(D-Ribofuranosyl)-Pyridine and 3-(D-Ribofuranosyl)-2- Pyridone Nucleosides and Nucleotides. 6: 245-248. DOI: 10.1080/07328318708056197  0.48
1986 Townsend LB, Kawasaki AM, VanSickle AP, Wotring LL. The synthesis and biological activity of certain pentaazaacenaphthylenes, hexaazaacenaphthylenes and their corresponding nucleosides Nucleic Acids Symposium Series. 41-44. PMID 3562273  0.371
1986 Wise DS, Townsend LB. Synthesis of the selenium analog of the cytokinin 6-(3-methyl-2-butenylamino)-2-methylthio-9-(β-D-ribofuranosyl)purine Nucleosides and Nucleotides. 5: 511-516. DOI: 10.1080/07328318608068693  0.353
1986 Belmans M, Vrijens I, Esmans E, Dommisse R, Lepoivre J, Alderweireldt F, Townsend L, Wotring L, Balzarini J, Clercq ED. Synthests and Biological Evaluation of a Series of Substituted-2-Pyridine-C-Nucleosides. Part II Nucleosides and Nucleotides. 5: 441-455. DOI: 10.1080/07328318608068685  0.48
1986 Cupps TL, Wise DS, Townsend LB. A novel three-step synthesis of a pyrrolo[3,2-d]pyrimidine C-nucleoside Journal of Organic Chemistry. 51: 1058-1064. DOI: 10.1021/Jo00357A021  0.477
1986 Acevedo OL, Krawczyk SH, Townsend LB. Total synthesis of (4R)- and (4S)-5,6-dihydro-1-.beta.-D-ribofuranosyl-4H-pyrazolo[3,4-d][1,3]diazepin-4-ol and (8R)- and (8S)-7,8-dihydro-3-.beta.-D-ribofuranosyl-6H-v-triazolo[4,5-d][1,3]diazepin-8-ol: two heterocyclic analogs of the nucleoside antibiotic coformycin Journal of Organic Chemistry. 51: 1050-1058. DOI: 10.1021/Jo00357A020  0.418
1986 Roberts DD, Arjunan P, Townsend LB, Goldstein IJ. Specificity of adenine binding to lima bean lectin Phytochemistry. 25: 589-593. DOI: 10.1016/0031-9422(86)88004-9  0.346
1986 Ram S, Wise DS, Townsend LB. Synthesis of 2-substituted benzimidazole-5-carbamates as potential antifilarial agents Journal of Heterocyclic Chemistry. 23: 1109-1113. DOI: 10.1002/Jhet.5570230430  0.352
1986 Chern J, Groziak MP, Townsend LB. An unexpected product from the cyclodesulfurization of 5-[1-(3-methoxycarbonyl)thioureido]-1-(β-D-ribofuranosyl)imidazole-4- carboxamide with dicyclohexylcarbodiimide Journal of Heterocyclic Chemistry. 23: 153-154. DOI: 10.1002/Jhet.5570230131  0.683
1986 Groziak MP, Townsend LB. A new and efficient synthesis of guanosine The Journal of Organic Chemistry. 51: 1277-1282. DOI: 10.1002/Chin.198642314  0.317
1986 ACEVEDO OL, KRAWCZYK SH, TOWNSEND LB. ChemInform Abstract: Total Synthesis of (4R)- and (4S)-5,6-Dihydro-1-β-D-ribofuranosyl-4H- pyrazolo[3,4-d][1,3]diazepin-4-ol (Ia) and (Ib) and of (8R)- and (8S)- 7,8-Dihydro-3-β-D-ribofuranosyl-6H-v-triazolo[4,5-d][1,3]diazepin-8-ol (Ic) and (Id): Two Het Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198639344  0.401
1986 Groziak MP, Chern JW, Townsend LB. Heterocyclic synthesis via a 1,3-dicyclohexylcarbodiimide-mediated cyclodesulfurative annulation reaction. New methodology for the preparation of guanosine and guanosine-type nucleoside analogues Journal of Organic Chemistry. 51: 1065-1069. DOI: 10.1002/Chin.198638323  0.362
1985 Rainey P, Nolan PA, Townsend LB, Robins RK, Fox JJ, Secrist Iii JA, Santi DV. Inosine analogs as anti-leishmanial agents. Pharmaceutical Research. 2: 217-20. PMID 24272839 DOI: 10.1023/A:1016360710842  0.481
1985 Patil VD, Wise DS, Wotring LL, Bloomer LC, Townsend LB. Synthesis and biological activity of a novel adenosine analogue, 3-β-D-ribofuranosylthieno[2,3-d]pyrimidin-4-one Journal of Medicinal Chemistry. 28: 423-427. PMID 3981534 DOI: 10.1021/Jm00382A006  0.489
1985 Ram S, Wise DS, Townsend LB. An improved synthesis of methyl [5-benzoyl- and 5-p-fluorobenzoylbenzimidazol-2-yl]carbamates Organic Preparations and Procedures International. 17: 215-218. DOI: 10.1080/00304948509355506  0.324
1985 Chern JW, Townsend LB. A novel and efficient synthesis of the naturally occurring nucleoside doridosine Tetrahedron Letters. 26: 6419-6422. DOI: 10.1016/S0040-4039(00)99016-6  0.724
1985 Ram S, Wise DS, Townsend LB. Synthesis of 2-thiobenzimidazole derivatives as potential antifilarial agents Journal of Heterocyclic Chemistry. 22: 1269-1274. DOI: 10.1002/Jhet.5570220525  0.355
1985 Acevedo OL, Krawczyk SH, Townsend LB. Synthesis of the new ring system, Pyrazolo[3,4-d][1,3]diazepine. A novel route for the synthesis of azolo[1,3]diazepines Journal of Heterocyclic Chemistry. 22: 349-352. DOI: 10.1002/Jhet.5570220225  0.461
1985 Townsend LB, Beylin VG, Wotring LL. Synthesis, Biochemical and Chemotherapeutic Activity of Some Azolo[1,3]Oxazine Nucleosides Nucleosides and Nucleotides. 4: 29-66. DOI: 10.1002/Chin.198611381  0.364
1985 RAM S, WISE DS, TOWNSEND LB. ChemInform Abstract: A SYNTHESIS OF CARBAMIC ACID (IMIDAZO-HETEROAROMATIC) METHYL ESTER DERIVATIVES USING METHOXYCARBONYL ISOTHIOCYANATE Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198504231  0.359
1984 Ram S, Skinner M, Kalvin D, Wise DS, Townsend LB, McCall JW, Worth D, Ortwine D, Werbel LM. Synthesis of potential antifilarial agents. 1. 1-(5-Benzoylbenzimidazol-2-yl)-3-alkyl- and -arylureas Journal of Medicinal Chemistry. 27: 914-917. PMID 6737434 DOI: 10.1002/Chin.198448191  0.402
1984 Chern J, Wise DS, Townsend LB. A Convenient Synthesis of 2-N-Methoxycarbonylaminooxazolo[5,4-d]pyrimidines Journal of Heterocyclic Chemistry. 21: 1245-1246. DOI: 10.1002/Jhet.5570210467  0.701
1984 Chern J, Wise DS, Townsend LB. The novel ring opening of an oxazolo[5,4-d]pyrimidine and subsequent rearrangement to form an imidazo[4,5-d]pyrimidine Heterocycles. 22: 2439-2441. DOI: 10.1002/Chin.198513202  0.45
1984 BEYLIN VG, KAWASAKI AM, CHENG CS, TOWNSEND LB. ChemInform Abstract: PYRROLOPYRIMIDINE NUCLEOSIDES. 19. A TOTAL SYNTHESIS OF THE NUCLEOSIDE ANTIBIOTIC CADEGUOMYCIN (2-AMINO-7-(β-D-RIBOFURANOSYL)PYRROLO(2,3-D)PYRIMIDIN-4-ONE-5-CARBOXYLIC ACID) Chemischer Informationsdienst. 15. DOI: 10.1002/chin.198408201  0.358
1983 Maruyama T, Wotring LL, Townsend LB. Pyrrolopyrimidine nucleosides. 18. Synthesis and chemotherapeutic activity of 4-amino-7-(3-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d] pyrimidine-5-carboxamide (3'-deoxysangivamycin) and 4-amino-7-(2-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d] pyrimidine-5-carboxamide (2'-deoxysangivamycin). Journal of Medicinal Chemistry. 26: 25-9. PMID 6827526 DOI: 10.1021/Jm00355A006  0.505
1983 Krauss JC, Cupps TL, Wise DS, Townsend LB. An Efficient One-Step Synthesis of 3-Oxoalkanenitriles Synthesis. 1983: 308-309. DOI: 10.1055/S-1983-30316  0.334
1983 Cupps TL, Wise DS, Townsend LB. Synthetic strategies for 2,4-dimethoxypyrrolo[3,2-d]pyrimidine The Journal of Organic Chemistry. 48: 1060-1064. DOI: 10.1021/Jo00155A026  0.421
1983 Beylin VG, Kawasaki AM, Cheng CS, Townsend LB. Pyrrolopyrimidine nucleosides 19. A total synthesis of the nucleoside antibiotic cadeguomycin [2-amino-7-(β-d-ribofuranosyl)-pyrrolo[2,3-]pyrimidin-4-one-5-carboxylic acid] Tetrahedron Letters. 24: 4793-4796. DOI: 10.1016/S0040-4039(00)94009-7  0.478
1983 Acevedo OL, Krawczyk SH, Townsend LB. A novel approach towards the synthesis of the 3,4,5-trihydro-1,3-diazepin-5-ol ring structure Tetrahedron Letters. 24: 4789-4792. DOI: 10.1016/S0040-4039(00)94008-5  0.346
1983 Katz DJ, Wise DS, Townsend LB. Synthesis and chemistry of some pyridazine nucleosides related to certain 5-substituted pyrimidine nucleosides Journal of Heterocyclic Chemistry. 20: 369-379. DOI: 10.1002/jhet.5570200221  0.303
1983 Cupps TL, Wise DS, Townsend LB. A further investigation of the stannic chloride-catalyzed condensation reaction of 1-hexene and 1,2,3,5-tetra-O-acyl-β-d-ribofuranoses Carbohydrate Research. 115: 59-73. DOI: 10.1002/Chin.198348306  0.407
1983 MARUYAMA T, WOTRING LL, TOWNSEND LB. ChemInform Abstract: PYRROLOPYRIMIDINE NUCLEOSIDES. 18, SYNTHESIS AND CHEMOTHERAPEUTIC ACTIVITY OF F 4-AMINO-7-(3-DEOXY-β-D-RIBOFURANOSYL)PYRROLO(2,3-D)PYRIMIDINE-5-CARBOXAMID# E (3′-DEOXYSANGIVAMYCIN) AND 4-AMINO-7-(2-DEOXY-β-D-RIBOFURANOSYL)PYRROLO(2,3- Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198326340  0.336
1983 CUPPS TL, WISE DS, TOWNSEND LB. ChemInform Abstract: A NOVEL METHOD FOR THE SYNTHESIS OF 6,7-UNSUBSTITUTED PYRROLO(3,2-D)PYRIMIDINES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198312237  0.364
1982 Katz DJ, Wise DS, Townsend LB. Synthesis of pyridazine analogues of the naturally occurring nucleosides cytidine, uridine, deoxycytidine, and deoxyuridine Journal of Medicinal Chemistry. 25: 813-821. PMID 7108897 DOI: 10.1021/Jm00349A009  0.448
1982 Lewis AF, Townsend LB. Pyrazolopyrimidine nucleosides. 13. Synthesis of the novel C-nucleoside 5-amino-3-(.beta.-D-ribofuranosyl)pyrazolo[4,3-d]pyrimidin-7-one, a guanosine analog related to the nucleoside antibiotic formycin B Journal of the American Chemical Society. 104: 1073-1077. DOI: 10.1021/Ja00368A026  0.495
1982 Cupps TL, Wise DS, Townsend LB. A novel method for the synthesis of 6,7-unsubstituted pyrrolo[3,2-d]pyrimidines Tetrahedron Letters. 23: 4759-4762. DOI: 10.1016/S0040-4039(00)85706-8  0.492
1981 Chung FL, Schram KH, Panzica RP, Earl RA, Wotring LL, Townsend LB. Synthesis of certain [6:5:6] linear tricyclic nucleosides as potential antitumor agents. Journal of Medicinal Chemistry. 23: 1158-66. PMID 7452664 DOI: 10.1021/Jm00185A002  0.414
1981 Bhat GA, Montero JLG, Panzica RP, Wotring LL, Townsend LB. Pyrazolopyrimidine nucleosides. 12. Synthesis and biological activity of certain pyrazolo[3,4-d]pyrimidine nucleosides related to adenosine Journal of Medicinal Chemistry. 24: 1165-1172. PMID 7328577 DOI: 10.1002/Chin.198211351  0.513
1981 Bhat GA, Townsend LB. Synthesis of certain fluorescent tricyclic nucleosides derived from pyrazolo[3,4-d]pyrimidine nucleosides Journal of the Chemical Society-Perkin Transactions 1. 12: 2387-2393. DOI: 10.1039/P19810002387  0.49
1981 Hernandez MA, Chung F, Earl RA, Townsend LB. General route for the facile synthesis of pyrimidin-2-one-4-thione derivatives via the annulation of cyclic o-aminonitriles using carbonyl sulfide The Journal of Organic Chemistry. 46: 3941-3945. DOI: 10.1021/Jo00333A001  0.354
1981 Chung F-, Schram KH, Panzica RP, Earl RA, Wotring LL, Townsend LB. Synthesis Of Certain (6:5:6) Linear Tricyclic Nucleosides As Potential Antitumor Agents Cheminform. 12. DOI: 10.1002/Chin.198113278  0.307
1980 Earl RA, Townsend LB. Synthesis and antileukemic activities of furanyl, pyranyl, and ribosyl derivatives of 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide and 3-(3,3-dimethyl-1-triazeno)pyrazole-4-carboxamide. Journal of Medicinal Chemistry. 22: 1422-5. PMID 533891 DOI: 10.1002/Chin.198012225  0.39
1980 Earl RA, Townsend LB. The synthesis of 8-aza-3-deazaguanosine [6-amino-1-(β-D-ribofuranosyl)-υ-triazolo[4,5-c]pyridin-4-one] via a novel 1,3-dipolar cycloaddition reaction Canadian Journal of Chemistry. 58: 2550-2561. DOI: 10.1139/V80-407  0.466
1980 Cline BL, Fagerness PE, Panzica RP, Townsend LB. The use of carbon-13 magnetic resonance chemical shifts and long-range <sup>13</sup>C-<sup>1</sup>H coupling constants for assigning the site of glycosylation on nitrogen heterocycles Journal of the Chemical Society, Perkin Transactions 2. 1586-1591. DOI: 10.1039/P29800001586  0.313
1980 Patil VD, Wise DS, Townsend LB. The synthesis of thieno[2,3-d]pyrimidine nucleosides related to the naturally occurring nucleosides cytidine and uridine Journal of the Chemical Society-Perkin Transactions 1. 11: 1853-1858. DOI: 10.1039/P19800001853  0.496
1980 Chung F, Earl RA, Townsend LB. Synthesis of 5-amino-9-(.beta.-D-ribofuranosyl)-v-triazino-[4,5-b]pyrimido[4,5-d]pyrrol-4-one and unusual ring opening of this new ring system with the Vilsmeier-Haack reagent The Journal of Organic Chemistry. 45: 2532-2535. DOI: 10.1021/Jo01300A063  0.47
1980 Lewis AF, Townsend LB. Pyrazolo[4,3-d]pyrimidine nucleosides. 9. Studies on the isomeric N-methylformycins Journal of the American Chemical Society. 102: 2817-2822. DOI: 10.1021/Ja00528A050  0.414
1980 Chung F, Earl RA, Townsend LB. The novel synthesis of a [6:5:6] linear isoguanosine type tricyclic nucleoside using carbonyl sulfide Tetrahedron Letters. 21: 1599-1602. DOI: 10.1016/S0040-4039(00)77763-X  0.391
1979 Miles DW, Townsend LB, Miles DL, Eyring H. Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides. Proceedings of the National Academy of Sciences of the United States of America. 76: 553-6. PMID 284380 DOI: 10.1073/Pnas.76.2.553  0.363
1979 Wise DS, Townsend LB. Synthesis of a novel selenium-bridged cyclonucleoside, Se 2,2′-cyclo-2-selenocytidine Journal of the Chemical Society, Chemical Communications. 271-272. DOI: 10.1039/C39790000271  0.375
1978 Graves BJ, Hodgson DJ, Katz DJ, Wise DS, Townsend LB. Conformation of pyridazine nucleosides. The molecular structure of 4-hydroxy-1-(β-d-ribofuranosyl)pyridazin-6-one (3-deaza-6-azauridine) Bba Section Nucleic Acids and Protein Synthesis. 520: 229-232. PMID 698230 DOI: 10.1016/0005-2787(78)90023-0  0.31
1978 Cline BL, Panzica RP, Townsend LB. 5-Amino-3-(.beta.-D-ribofuranosyl)-v-triazolo[4,5-b]pyridin-7-one (1-deaza-8-azaguanosine) and certain related derivatives The Journal of Organic Chemistry. 43: 4910-4915. DOI: 10.1021/Jo00420A002  0.405
1977 Montero JLG, Bhat GA, Panzica RP, Townsend LB. Pyrazolopyrimidine nucleosides. Part VIII The synthesis of certain 4‐substituted pyrazolo[3,4‐d]pyrimidine nucleosides Journal of Heterocyclic Chemistry. 14: 483-487. DOI: 10.1002/jhet.5570140326  0.317
1976 May JA, Townsend LB. Synthesis of V-triazolo(4,5-c)pyridine nucleosides and 4-(beta-D-ribofuranosyl)amino-1,2,3-thiadiazolo(5,4-b)pyridine via a rearrangement. The Journal of Organic Chemistry. 41: 1449-56. PMID 1263007 DOI: 10.1021/Jo00870A035  0.451
1976 Miles DW, Townsend LB, Redington P, Eyring H. Comparative study by circular dichroism of the conformation of deazapurine nucleosides and that of common purine nucleosides. Proceedings of the National Academy of Sciences of the United States of America. 73: 2384-7. PMID 1065890 DOI: 10.1073/Pnas.73.7.2384  0.354
1976 Townsend LB, Milne GH. Synthesis, chemical reactivity, and chemotherapeutic activity of certain selenonucleosides and nucleosides related to the pyrrolo(2,3-d)pyrimidine nucleoside antibiotics. Annals of the New York Academy of Sciences. 255: 91-103. PMID 1059377 DOI: 10.1111/j.1749-6632.1975.tb29216.x  0.355
1976 Cheng CS, Hinshaw BC, Panzica RP, Townsend LB. Synthesis of 2-amino-5-cyano-7-(β-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidin-4-one. An important precursor for the synthesis of nucleoside Q and Q [37] Journal of the American Chemical Society. 98: 7870-7872. PMID 993507 DOI: 10.1021/Ja00440A094  0.42
1976 Chenon MT, Panzica RP, Smith JC, Pugmire RJ, Grant DM, Townsend LB. Carbon-13 magnetic resonance spectra of C-nucleosides. 3. la-c Tautomerism in formycin and formycin B and certain pyrazolo[4,3-d]pyrimidines. Journal of the American Chemical Society. 98: 4736-45. PMID 950416 DOI: 10.1021/Ja00432A008  0.334
1976 Thurber TC, Townsend LB. Ring contractions of 5-diazouracils. I. Conversions of 5-diazouracils into 1,2,3-triazoles by hydrolysis and methanolysis. The Journal of Organic Chemistry. 41: 1041-57. PMID 942590 DOI: 10.1021/Jo00868A026  0.3
1976 Milne GH, Townsend LB. Pyrrolopyrimidine nucleosides. XIII. Synthesis and chemical reactivity of certain selenopyrrolo[2,3-d]pyrimidine nucleosides Journal of Heterocyclic Chemistry. 13: 745-748. DOI: 10.1002/jhet.5570130411  0.376
1975 Schmidt CL, Townsend LB. Bicyclic nucleosides related to pyrimidine nucleosides. Part III. 3-(β-D-ribofuranosyl)isoguanine Journal of the Chemical Society, Perkin Transactions 1. 1257-1260. PMID 1171886 DOI: 10.1039/P19750001257  0.428
1975 Hinshaw BC, Leonoudakis O, Schram KH, Townsend LB. Pyrrolopyrimidine nucleosides. Part X. Synthesis of certain 4,5-disubstituted 7-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines related to toyocamycin and sangivamycin. Journal of the Chemical Society. Perkin Transactions 1. 1248-53. PMID 1171884 DOI: 10.1039/P19750001248  0.443
1975 Schmidt CL, Townsend LB. Bicyclic nucleosides related to pyrimidine nucleosides. IV. Synthesis of 4-and 6-ribofuranosylthiazolo(5,4-d)pyrimidines and 4-arabinofuranosylthiazolo(5,4-d)pyrimidines. The Journal of Organic Chemistry. 40: 2476-81. PMID 1165508 DOI: 10.1021/Jo00905A013  0.477
1975 Schram KH, Townsend LB. Pyrrolopyrimidine nucleosides. Part XI. Influence of amino-groups at C-4 and C-6 or an amino-group at C-6 on the reactivity of a 5-cyano-group in pyrrolo(2,3-d)pyrimidine nucleosides. Journal of the Chemical Society-Perkin Transactions 1. 6: 1253-1257. DOI: 10.1039/P19750001253  0.456
1975 May JAJ, Townsend LB. A general synthesis of 4-substituted 1-(beta-D-ribofuranosyl) imidazo-[4, 5-c] pyridines. Journal of the Chemical Society-Perkin Transactions 1. 6: 125-129. DOI: 10.1039/P19750000125  0.519
1975 Earl RA, Pugmire RJ, Revankar GR, Townsend LB. Chemical and carbon-13 nuclear magnetic resonance reinvestigation of the N-methyl isomers obtained by direct methylation of 5-amino-3,4-dicyanopyrazole and the synthesis of certain pyrazolo[3,4-d]pyrimidines The Journal of Organic Chemistry. 40: 1822-1828. DOI: 10.1021/Jo00900A030  0.384
1975 Schram KH, Manning SJ, Townsend LB. Tricyclic nucleosides I. Synthesis of the new tricyclic ring system tetrazolo[1,5-c]pyrrolo[2,3-d]pyrimidine and certain tetrazolo[],5-c] pyrrolo[2,3-d] pyrimidine ribonucleosides Journal of Heterocyclic Chemistry. 12: 1021-1023. DOI: 10.1002/jhet.5570120540  0.357
1975 CHENON M, PUGMIRE RJ, GRANT DM, PANZICA RP, TOWNSEND LB. ChemInform Abstract: (13)C-NMR PART 25, A BASIC SET OF PARAMETERS FOR THE INVESTIGATION OF TAUTOMERISM IN PURINES ESTABLISHED FROM (13)C-NMR STUDIES USING CERTAIN PURINES AND PYRROLO(2,3-D)PYRIMIDINES Chemischer Informationsdienst. 6. DOI: 10.1002/Chin.197542049  0.357
1975 Patil VD, Wise DS, Townsend LB, Bloch A. Synthesis And Biological Activity Of Selected 2-Substituted 6-(Beta-D-Ribofuranosyl)Oxazolo(5,4-D)Pyrimidin-7-Ones Cheminform. 6. DOI: 10.1002/Chin.197515433  0.482
1975 MAY JAJ, TOWNSEND LB. ChemInform Abstract: A GENERAL SYNTHESIS OF 4-SUBSTITUTED 1-(BETA-D-RIBOFURANOSYL)IMIDAZO-(4,5-C)PYRIDINES Chemischer Informationsdienst. 6: no-no. DOI: 10.1002/chin.197515431  0.368
1974 Townsend LB, Long RA, McGraw JP, Miles DW, Robins RK, Eyring H. Pyrazolopyrimidine nucleosides. V. Methylation of the C-nucleoside antibiotic formycin and structural elucidation of products by magnetic circular dichroism spectroscopy. The Journal of Organic Chemistry. 39: 2023-7. PMID 4846181 DOI: 10.1021/Jo00928A009  0.457
1974 Milne GH, Townsend LB. Synthesis and antitumor activity of alpha-and beta-2'-deoxy-6-selenoguanosine and certain related derivatives. Journal of Medicinal Chemistry. 17: 263-8. PMID 4811220 DOI: 10.1002/Chin.197433455  0.333
1974 Patil VD, Wise DS, Townsend LB, Bloch A. Synthesis and biological activity of selected 2-substituted 6-(β-D-ribofuranosyl)oxazolo[5,4-d]pyrimidin-7-ones Journal of Medicinal Chemistry. 17: 1282-1285. PMID 4610135 DOI: 10.1021/Jm00258A010  0.447
1974 Schram KH, Townsend LB. Fluorescent nucleoside derivatives of imidazo[1,2-c]pyrrolo[2,3-d]pyrimidine a new and novel heterocyclic ring system. Tetrahedron Letters. 15: 1345-1348. DOI: 10.1016/S0040-4039(01)82484-9  0.307
1974 Earl RA, Townsend LB. Pyrazolopyrimidine nucleosides. Part VII. The synthesis of certain pyrazolo [3,4-d] pyrimidine nucleosides related to the nucleoside antibiotics toyocamycin and sangivamycin Journal of Heterocyclic Chemistry. 11: 1033-1039. DOI: 10.1002/jhet.5570110633  0.377
1974 Rousseau RJ, May JA, Robins RK, Townsend LB. The synthesis of 3-deaza-6-thioguanine and certain related derivatives Journal of Heterocyclic Chemistry. 11: 233-235. DOI: 10.1002/Jhet.5570110225  0.455
1973 Panzica RP, Townsend LB. The total synthesis of the alkaloid casimiroedine, an imidazole nucleoside Journal of the American Chemical Society. 95: 8737-8740. PMID 4783411 DOI: 10.1002/Chin.197411482  0.394
1973 Panzica RP, Townsend LB. Synthesis of imidazo[4,5-b]pyrazine nucleosides Journal of the Chemical Society, Perkin Transactions 1. 244-248. PMID 4736246 DOI: 10.1039/P19730000244  0.408
1973 McCloskey JA, Futrell JH, Elwood TA, Schram KH, Panzica RP, Townsend LB. Determination of relative glycosyl bond strengths in nucleosides by chemical ionization mass spectrometry. A comparative study of 7- and 9-beta-D-ribofuranosylpurines. Journal of the American Chemical Society. 95: 5762-4. PMID 4733818 DOI: 10.1002/Chin.197343134  0.335
1973 Pugmire RJ, Grant DM, Townsend LB, Robins RK. Carbon-13 magnetic resonance. XXII. The N-methylpurines. Journal of the American Chemical Society. 95: 2791-6. PMID 4694712 DOI: 10.1021/Ja00790A008  0.395
1973 Leutzinger EE, Meguro T, Townsend LB. The direct utilization of unsaturated sugars in nucleoside syntheses. The synthesis, configuration, and conformation of certain hex-1-enitol-3-yl, hex-2-enopyranosyl-, and hexopyranosylpurines. The preparation of 9-(1,5-anhydro-2,3-dideoxy-D-arabino-hex-1-enitol-3-yl)adenine and 9-(2,3-dideoxy- -D-erythro-hex-2-enopyranosyl)adenine from D-glucal. The Journal of Organic Chemistry. 37: 3695-702. PMID 4639033 DOI: 10.1021/jo00796a028  0.392
1973 Milne GH, Townsend LB. Purine nucleosides. Part XXXII. Synthesis and reactivity of 6-alkyl-seleno-9-(β-D-ribofuranosyl)purines Journal of the Chemical Society-Perkin Transactions 1. 3: 313-315. DOI: 10.1039/P19730000313  0.444
1973 Patil VD, Wise DS, Townsend LB. The synthesis of 2-ethyl-6-β-d-ribofuranosyl)oxazolo[5,4-d]phyrimidin-7-one Journal of Heterocyclic Chemistry. 10: 277-278. DOI: 10.1002/Jhet.5570100234  0.452
1973 PUGMIRE RJ, GRANT DM, TOWNSEND LB, ROBINS RK. ChemInform Abstract: MAGNETISCHE RESONANZ VON KOHLENSTOFF-13 22. MITT. N-METHYLPURINE Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197327070  0.425
1973 MILNE GH, TOWNSEND LB. ChemInform Abstract: PURIN-NUCLEOSIDE 32. MITT. SYNTH. UND REAKTIVITAET VON 6-ALKYLSELENO-9-(BETA-D-RIBO-FURANOSYL)-PURINEN Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197314481  0.404
1973 LEUTZINGER EE, MEGURO T, TOWNSEND LB, SHUMAN DA, SCHWEIZER MP, STEWART CM, ROBINS RK. ChemInform Abstract: UNGESAETTIGTE ZUCKER BEI NUCLEOSID-SYNTH., SYNTH. UND KONFORM. EINIGER HEX-1-ENITOL-3-YL-, HEX-2-ENO- UND HEXOPYANOSYL-PURINE, HERST. VON 9-(1,5-ANHYDRO-2,3-DIDESOXY-D-ARABINO-HEX-1-ENITOL-3-YL)UND 9-(2,3-DIDESOXY-BETA-D-ERYTHROHEX-2- Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197309468  0.519
1973 MILNE GH, TOWNSEND LB. ChemInform Abstract: PYRAZOLOPYRIMIDIN-NUCLEOSIDE 4. MITT. SYNTH. UND CHEMISCHE REAKTIVITAET DES C-NUCLEOSIDS SELENOFORMYCIN B UND DERIVATEN Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197303445  0.309
1973 EARL RA, PANZICA RP, TOWNSEND LB. ChemInform Abstract: PYRAZOLOPYRIMIDIN-NUCLEOSIDE 3. MITT. SYNTH. VON 1- UND 2-(BETA-D-RIBOFURANOSYL)-PYRAZOLO(3,4-D)PYRIMIDINEN AUS PYRAZOLNUCLEOSID-DERIVATEN Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197303444  0.428
1972 Panzica RP, Rousseau RJ, Robins RK, Townsend LB. A study on the relative stability and a quantitative appraoch to the reaction mechanism of the acid-catalyzed hydrolysis of certain7-and9- -D-ribofuranosylpurines. Journal of the American Chemical Society. 94: 4708-14. PMID 5044241 DOI: 10.1021/Ja00768A045  0.516
1972 Milne GH, Townsend LB. Pyrazolopyrimidine nucleosides. Part IV. Synthesis and chemical reactivity of the C-nucleoside selenoformycin B and derivatives Journal of the Chemical Society, Perkin Transactions 1. 2677-2681. PMID 4674611 DOI: 10.1039/P19720002677  0.354
1972 Earl RA, Panzica RP, Townsend LB. Pyrazolopyrimidine nucleosides. Part III. Synthesis of 1- and 2-(β-D-ribofuranosyl)pyrazolo[3,4-d]pyrimidines from pyrazole nucleo-side derivatives Journal of the Chemical Society, Perkin Transactions 1. 2672-2677. PMID 4674610 DOI: 10.1039/P19720002672  0.471
1972 Earl RA, Townsend LB. The synthesis of 1 (tetrahydro-2-furanyl)-5-fluorouracil (ftorafur)viadirect fluorination Journal of Heterocyclic Chemistry. 9: 1141-1143. DOI: 10.1002/Jhet.5570090533  0.307
1972 PANZICA RP, ROUSSEAU RJ, ROBINS RK, TOWNSEND LB. ChemInform Abstract: RELATIVE STABILITAET UND QUANTITATIVE BEHANDLUNG DES RK.-MECHANISMUS DER SAEUREKATALYSIERTEN HYDROLYSE VON 7- UND 9-BETA-D-RIBOFURANOSYL-PURINEN Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197238117  0.538
1972 TOLMAN RL, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PYRROLOPYRIMIDIN-NUCLEOSIDE 7. MITT. UNTERSUCHUNG DER ELEKTROPHILEN UND NUCLEOPHILEN SUBSTITUTION IN 6-STELLUNG EINIGER PYRROLO(2,3-D)PYRIMIDIN-NUCLEOSIDE Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/Chin.197217459  0.556
1972 SCHMIDT CL, RUSHO WL, TOWNSEND LB. ChemInform Abstract: DIE SYNTH. BICYCLISCHER NUCLEOSIDE, DIE MIT URIDIN VERWANDT SIND, 4-(D-RIBOFURANOSYL)-THIAZOLO(5,4-D)PYRIMIDINE Chemischer Informationsdienst. 3: no-no. DOI: 10.1002/chin.197211443  0.32
1971 Panzica RP, Robins RK, Townsend LB. Synthesis and anticancer activity of cytosine arabinoside 3-N-oxide (ara-C 3-N-oxide). Journal of Medicinal Chemistry. 14: 259-60. PMID 5552224 DOI: 10.1021/Jm00285A028  0.449
1971 Miles DW, Townsend LB, Robins MJ, Robins RK, Inskeep WH, Eyring H. Circular dichroism of nucleoside derivatives. X. Influence of solvents and substituents upon the Cotton effects of guanosine derivatives. Journal of the American Chemical Society. 93: 1600-8. PMID 5550248  0.551
1971 Long RA, Lewis AF, Robins RK, Townsend LB. Pyrazolopyrimidine nucleosides. Part II. 7-Substituted 3- -D-ribofuranosylpyrasolo(4,3-d)pyrimidines related to and derived from the nucleoside antibiotics formycin and formycin B. Journal of the Chemical Society. Perkin Transactions 1. 13: 2443-6. PMID 5166604 DOI: 10.1039/J39710002443  0.592
1971 Long RA, Lewis AF, Robins RK, Townsend LB. Pyrazolopyrimidine nucleosides. Part II. 7-Substituted 3-β-D- ribofuranosylpyrazolo[4,3-d]pyrimidines related to and derived from the nucleoside antibiotics formycin and formycin B Journal of the Chemical Society C: Organic Chemistry. 2443-2446. DOI: 10.1039/J39710002443  0.532
1971 Schmidt CL, Rusho WJ, Townsend LB. The synthesis of bicyclic nucleosides related to uridine, 4-(β-D-ribofuranosyl)thiazolo[5,4-d]pyrimidines Journal of the Chemical Society D: Chemical Communications. 1515-1516. DOI: 10.1039/C29710001515  0.465
1971 Panzica R, Townsend L. A New Synthesis of 5-Amino-1-(β-D-ribofuranosyl)imidazole-4-carboxamide (AICA Riboside) via the Reduction of 1-(β-D-Ribofuranosyl)-5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DIC Riboside) The Journal of Organic Chemistry. 36: 1594-1596. DOI: 10.1021/Jo00811A600  0.429
1971 Tolman RL, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides VII. A study on electrophilic and nucleophilic substitution at position six of certain pyrrolo[2,3-d] pyrimidine nucleosides Journal of Heterocyclic Chemistry. 8: 703-706. DOI: 10.1002/Jhet.5570080502  0.559
1971 Patil VD, Townsend LB. The synthesis of certain 2,7-disubstituted oxazolo[5,4-d] pyrimidines Journal of Heterocyclic Chemistry. 8: 503-505. DOI: 10.1002/jhet.5570080327  0.386
1971 PATIL VD, TOWNSEND LB. ChemInform Abstract: DIE SYNTH. BESTIMMTER 2,7-DISUBSTITUIERTER OXAZOLO(5,4-D)PYRIMIDINE Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/chin.197145359  0.319
1971 LONG RA, LEWIS AF, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PYRAZOLOPYRIMIDIN-NUCLEOSIDE 2. MITT. DEN NUCLEOSID-ANTIBIOTICA FORMYCIN UND FORMYCIN B VERWANDTE UND VON IHNEN ABGELEITETE 7-SUBSTITUIERTE 3-BETA-D-RIBOFURANOSYL-PYRAZOLO(4,3-D)PYRIMIDINE Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197141388  0.577
1971 REVANKAR GR, TOWNSEND LB. ChemInform Abstract: PYRAZOLOPYRIMIDIN-NUCLEOSIDE 1. MITT. SYNTH. VON PYRAZOLOPYRIMIDIN-NUCLEOSIDEN, VERWANDT DEM NUCLEOSID-ANTIBIOTICUM TUBERCIDIN Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197141387  0.329
1971 MILES DW, TOWNSEND LB, ROBINS MJ, ROBINS RK, INSKEEP WH, EYRING H. ChemInform Abstract: CIRCULARDICHROISMUS VON NUCLEOSIDDERIVATIVEN 10. MITT. LOESUNGSMITTEL- UND SUBSTITUENTENEINFLUSS AUF DIE COTTON-EFFEKTE VON GUANOSINDERIVATEN Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197125072  0.513
1970 Rousseau RJ, Townsend LB. Purine nucleosides. XXI. The synthesis of 6-amino-2-methylthio-7-(beta-D-ribofuranosyl)purine, an anomer of the nucleoside from Factor F, by ring closure of an imidazole nucleoside. The Journal of Organic Chemistry. 33: 2828-30. PMID 5742847 DOI: 10.1021/Jo01271A047  0.426
1970 Leutzinger EE, Robins RK, Townsend LB. The direct utilization of unsaturated sugars in nucleoside synthesis. 3-deoxy-3-(6-chloro-2-methylthio-9-purinyl)-D-erythro-hex-1-enopyranose, a new and novel type of purine nucleoside. Tetrahedron Letters. 3751-3. PMID 5474707 DOI: 10.1016/S0040-4039(01)98579-X  0.537
1970 Panzica RP, Townsend LB. The synthesis of 5,6-dimethyl-1-(β-D-ribofuranosyl)imidazo[4,5-b]pyrazine by ring closure of an imidazole nucleoside, a new bicyclic nucleoside Tetrahedron Letters. 11: 1013-1015. PMID 5439232 DOI: 10.1016/S0040-4039(01)97894-3  0.355
1970 Rousseau RJ, Panzica RP, Reddick SM, Robins RK, Townsend LB. Purine nucleosides. XXVI. A general synthesis of 6-substituted 9-(beta-D-ribofuranosyl) purines. A reinvestigation and corroboration of the position of glycosylation of 6-dimethylamino-"7"-(beta-D-ribofuranosyl) purine. The Journal of Organic Chemistry. 35: 631-5. PMID 5416935 DOI: 10.1021/Jo00828A018  0.569
1970 Hinshaw BC, Gerster JF, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides. V. A study on the relative chemical reactivity of the 5-cyano group of the nucleoside antibiotic toyocamycin and desaminotoyocamycin. The synthesis of analogs of sangivamycin. The Journal of Organic Chemistry. 35: 236-41. PMID 5410625 DOI: 10.1021/Jo00826A049  0.488
1970 Tolman RL, Tolman GL, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides. VI. Synthesis of 1,3 and 7-β-D-ribofuranosylpyrrolo[2.3-d] pyrimidinesviasilylated intermediates Journal of Heterocyclic Chemistry. 7: 799-806. DOI: 10.1002/Jhet.5570070408  0.551
1970 Rousseau RJ, Robins RK, Townsend LB. Purine nucleosides XXVIII. The synthesis of 7-(2′-deoxy-α- and β-d-ribofuranosyl)purines from 2′-deoxyribofuranosylimidazoles. Preparation of the 2′-deoxy derivative of the nucleoside from pseudovitamin B12factor G Journal of Heterocyclic Chemistry. 7: 367-372. DOI: 10.1002/Jhet.5570070219  0.525
1970 TOLMAN RL, TOLMAN GL, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PYRROLOPYRIMIDIN-NUCLEOSIDE 6. MITT. SYNTH. VON 1,3- UND 7-BETA-D-RIBOFURANOSYL-PYRROLO(2,3-D)PYRIMIDINEN UEBER SILYLIERTE ZWISCHENSTUFEN Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197051431  0.506
1970 LONG RA, GERSTER JF, TOWNSEND LB. ChemInform Abstract: DERIVATE DES RINGSYST. PYRAZOLO(4,3-D)-VIC.-TRIAZIN UND SYNTH. VON 5,7-DISUBSTITUIERTEN 3-METHYL-PYRAZOLO(4,3-D)PYRIMIDINEN UND IHREN OXIDEN MIT STRUKTURELLER ANALOGIE ZU FORMYCIN UND FORMYCIN B Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/chin.197051382  0.34
1970 LEUTZINGER EE, ROBINS RK, TOWNSEND LB. ChemInform Abstract: DIREKTE VERW. UNGESAETTIGTER ZUCKER BEI DER SYNTH. VON NUCLEOSIDEN, 3-DESOXY-3-(6-CHLOR-2-METHYLTHIO-9-PURINYL)-D-ERYTHRO-HEX-1-ENO-PYRANOSE, EIN NEUES PURIN-NUCLEOSID Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197049396  0.509
1970 ROUSSEAU RJ, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PURIN-NUCLEOSIDE 28. MITT. SYNTH. VON 7-(2′-DESOXY-ALPHA- UND -BETA-D-RIBOFURANOSYL)-PURINEN AUS 2′-DESOXY-RIBOFURANOSYLIMIDAZOLEN, HERST. DES 2′-DESOXY-DERIVATES DES NUCLEOSIDS AUS PSEUDOVITAMIN B12 FAKTOR G Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/chin.197032441  0.473
1970 ROUSSEAU RJ, PANZICA RP, REDDICK SM, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PURIN-NUCLEOSIDE 26. MITT. ALLGEMEINE SYNTH. FUER 6-SUBSTITUIERTE 7-(BETA-D-RIBOFURANOSYL)-PURINE, ANGRIFF DER GLYKOSYLIERUNG VON 6-DIMETHYLAMINO ′7′-(BETA-D-RIBOFURANOSYL)-PURIN Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/chin.197025376  0.475
1970 HINSHAW BC, GERSTER JF, ROBINS RK, TOWNSEND LB. ChemInform Abstract: PYRROLOPYRIMIDIN-NUCLEOSIDE 5. MITT. RELATIVE CHEMISCHE REAKTIVITAET DER 5-CYANOGRUPPIERUNG BEI DEN NUCLEOSID-ANTIBIOTICA TOYOCAMYCIN UND DESAMINO-TOYOCAMYCIN, SYNTH. VON ANALOGA DES SANGIVAMYCINS Chemischer Informationsdienst. Organische Chemie. 1: no-no. DOI: 10.1002/Chin.197021382  0.393
1969 Tolman RL, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides. 3. The total synthesis of toyocamycin, sangivamycin, tubercidin, and related derivatives. Journal of the American Chemical Society. 91: 2102-8. PMID 5805382 DOI: 10.1021/Ja01036A040  0.527
1969 Long RA, Robins RK, Townsend LB. Purine nucleosides. XXX. The chemical synthesis of N2-hydroxyguanosine (2-hydroxylamino-9-beta-D-ribofuranosyl-6-purinone, 2-HAPR-6-one). Biochimica Et Biophysica Acta. 195: 584-6. PMID 5366941 DOI: 10.1016/0005-2787(69)90669-8  0.511
1969 Hinshaw BC, Gerster JF, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides. IV. The synthesis of certain 4,5-disubstituted-7-(β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines related to the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics Journal of Heterocyclic Chemistry. 6: 215-221. DOI: 10.1002/Jhet.5570060212  0.553
1969 Gerster JF, Hinshaw BC, Robins RK, Townsend LB. A study of electrophilic substitution in the pyrrolo[2,3-d]pyrimidine ring Journal of Heterocyclic Chemistry. 6: 207-213. DOI: 10.1002/Jhet.5570060211  0.542
1968 Tolman RL, Townsend LB. The synthesis of 4,5-diamino-8-β-D-ribofuranosylpyrazolo[3′,4′-5,4]pyrrolo[2,3-d]pyrimidine, a novel tricyclic nucleoside Tetrahedron Letters. 9: 4815-4818. PMID 5679312 DOI: 10.1016/S0040-4039(00)75965-X  0.378
1968 Leutzinger EE, Robins RK, Townsend LB. The direct utilization of unsaturated sugars in nucleoside syntheses. An approach to the preparation of analogs of blasticidin S. Synthesis of 9-(2',3'-didehydro-2',3'-dideoxy-D-erythro-hexopyranosyl)guanine. Tetrahedron Letters. 4475-8. PMID 5678608 DOI: 10.1016/S0040-4039(01)99164-6  0.537
1968 Rousseau RJ, Robins RK, Townsend LB. Purine nucleosides. XX. The synthesis of 7-beta-D-ribofuranosylpurines from imidazole nucleoside derivatives. Journal of the American Chemical Society. 90: 2661-8. PMID 5651072 DOI: 10.1021/Ja01012A035  0.593
1968 Gerster JF, Hinshaw BC, Robins RK, Townsend LB. Purine nucleosides. XIX. The synthesis of certain 8-chloropurine nucleosides and related derivatives. The Journal of Organic Chemistry. 33: 1070-3. PMID 5639343 DOI: 10.1021/Jo01267A027  0.54
1968 Tolman RL, Robins RK, Townsend LB. Pyrrolo[2,3-d]pyrimidine nucleoside antibiotics. Total synthesis and structure of toyocamycin, unamycin B, vengicide, antibiotic E-212, and Sangivamycin (BA-90912). Journal of the American Chemical Society. 90: 524-6. PMID 5634627 DOI: 10.1021/Ja01004A076  0.542
1968 Leutzinger EE, Bowles WA, Robins RK, Townsend LB. Purine nucleosides. 18. The direct utilization of unsaturated sugars in nucleoside syntheses. The conformation and structure of certain 9-(2-deoxyribopyranosyl)purines prepared from D-arabinal. Journal of the American Chemical Society. 90: 127-36. PMID 5634596 DOI: 10.1021/Ja01003A023  0.582
1968 Hinshaw BC, Robins RK, Townsend LB. The synthesis of 4-hydroxylamino-7(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine(7-deaza-HAPR) Journal of Heterocyclic Chemistry. 5: 885-885. DOI: 10.1002/Jhet.5570050629  0.582
1968 Revankar GR, Townsend LB. A convenient synthesis of certain 1-(β-D-ribofuranosyl)benzotriazoles Journal of Heterocyclic Chemistry. 5: 785-788. DOI: 10.1002/jhet.5570050608  0.322
1968 Revankar GR, Townsend LB. The synthesis of 2-chloro-1-(β-D-ribofuranosyl)benzimidazole and certain related derivatives Journal of Heterocyclic Chemistry. 5: 477-483. DOI: 10.1002/jhet.5570050407  0.347
1967 Gerster JF, Carpenter B, Robins RK, Townsend LB. Pyrrolopyrimidine Nucleosides. I. The Synthesis of 4-Substituted 7-(- D -Ribofuranosyl)pyrrolo[2,3-d]pyrimidines from Tubercidin. Journal of Medicinal Chemistry. 10: 326-31. PMID 22185124 DOI: 10.1021/Jm00315A008  0.607
1967 Darnall KR, Townsend LB, Robins RK. The structure of showdomycin, a novel carbon-linked nucleoside antibiotic related to uridine. Proceedings of the National Academy of Sciences of the United States of America. 57: 548-53. PMID 16591497 DOI: 10.1073/Pnas.57.3.548  0.421
1967 Long RA, Robins RK, Townsend LB. Purine nucleosides. XV. The synthesis of 8-aminoand 8-substituted aminopurine nucleosides. The Journal of Organic Chemistry. 32: 2751-6. PMID 6073218 DOI: 10.1021/Jo01284A024  0.56
1967 Rousseau RJ, Robins RK, Townsend LB. The synthesis of 2-nitro-1-β-D-ribofuranosylimidazole (azomycin riboside) Journal of Heterocyclic Chemistry. 4: 311-312. DOI: 10.1002/Jhet.5570040228  0.506
1967 Pan YH, Robins RK, Townsend LB. Purine nucleosides XVII. The synthesis and conformation of 6-amino-9-β-D-ribopyranosylpurine and related derivatives prepared via the fusion procedure Journal of Heterocyclic Chemistry. 4: 246-250. DOI: 10.1002/Jhet.5570040213  0.534
1967 Tolman RL, Robins RK, Townsend LB. Pyrrolopyrimidine nucleosides II. the total synthesis of 7-β-D-ribofuranosylpyrrolo[2,3-d]pyrimidines related to toyocamycin Journal of Heterocyclic Chemistry. 4: 230-238. DOI: 10.1002/Jhet.5570040211  0.552
1966 Rousseau RJ, Townsend LB, Robins RK. The synthesis of 4-amino-beta-d-ribofuranosylimidazo[4,5-c]pyridine (3-deazaadenosine) and related nucleotides. Biochemistry. 5: 756-60. PMID 5940959 DOI: 10.1021/Bi00866A050  0.577
1966 McCarthy JR, Robins MJ, Townsend LB, Robins RK. Purine nucleosides. XIV. Unsaturated furanosyl adenine nucleosides prepared via base-catalyzed elimination reactions of 2'-deoxyadenosine derivatives. Journal of the American Chemical Society. 88: 1549-53. PMID 5914527 DOI: 10.1021/Ja00959A043  0.62
1966 Rousseau RJ, Townsend LB, Robins RK. Synthesis of 7-glycosylpurines Chemical Communications (London). 265-266. DOI: 10.1039/C19660000265  0.52
1966 Townsend LB, Robins RK. 3‐Methylpurine Journal of Heterocyclic Chemistry. 3: 241-242. DOI: 10.1002/Jhet.5570030233  0.442
1966 Robins RK, Townsend LB, Cassidy F, Gerster JF, Lewis AF, Miller RL. Structure of the nucleoside antibiotics formycin, formyein B and laurusin Journal of Heterocyclic Chemistry. 3: 110-114. DOI: 10.1002/Jhet.5570030130  0.35
1964 BROOM AD, TOWNSEND LB, JONES JW, ROBINS RK. PURINE NUCLEOSIDES. VI. FURTHER METHYLATION STUDIES OF NATURALLY OCCURRING PURINE NUCLEOSIDES. Biochemistry. 3: 494-500. PMID 14188163 DOI: 10.1021/Bi00892A005  0.479
1964 Townsend LB, Robins RK, Loeppky RN, Leonard NJ. Purine Nucleosides. VIII. Reinvestigation of the Position of Glycosidation in Certain Synthetic “7”-Substituted 6-Dimethylaminopurine Nucleosides Related to Puromycin Journal of the American Chemical Society. 86: 5320-5325. DOI: 10.1021/Ja01077A054  0.503
1963 Townsend LB, Robins RK. Ring Cleavage of Purine Nucleosides to Yield Possible Biogenetic Precursors of Pteridines and Riboflavin Journal of the American Chemical Society. 85: 242-243. DOI: 10.1021/Ja00885A039  0.504
1962 TOWNSEND LB, ROBINS RK. Potential Purine Antagonists. XXIX. The Synthesis of 1-Methylpurine and Related Derivatives1 The Journal of Organic Chemistry. 27: 990-993. DOI: 10.1021/Jo01050A073  0.491
1962 Townsend LB, Robins RK. Potential Purine Antagonists. XXXIV. The Synthesis of 3-Methylguanine and a Study of the Structure and Chemical Reactivity of Certain 3-Methylpurines Journal of the American Chemical Society. 84: 3008-3012. DOI: 10.1021/Ja00874A034  0.48
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