Yeeman K. Ramtohul - Publications

Affiliations: 
2002 University of Alberta, Edmonton, Alberta, Canada 

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Fournier PA, Arbour M, Cauchon E, Chen A, Chefson A, Ducharme Y, Falgueyret JP, Gagné S, Grimm E, Han Y, Houle R, Lacombe P, Lévesque JF, MacDonald D, Mackay B, ... ... Ramtohul Y, et al. Design and synthesis of potent, isoxazole-containing renin inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2670-4. PMID 22450130 DOI: 10.1016/j.bmcl.2012.03.014  0.8
2012 Tan CM, Therien AG, Lu J, Lee SH, Caron A, Gill CJ, Lebeau-Jacob C, Benton-Perdomo L, Monteiro JM, Pereira PM, Elsen NL, Wu J, Deschamps K, Petcu M, Wong S, ... ... Ramtohul Y, et al. Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics. Science Translational Medicine. 4: 126ra35. PMID 22440737 DOI: 10.1126/scitranslmed.3003592  0.8
2012 Lacombe P, Arbour M, Aspiotis R, Cauchon E, Chen A, Dubé D, Falgueyret JP, Fournier PA, Gallant M, Grimm E, Han Y, Juteau H, Liu S, Mellon C, Ramtohul Y, et al. 3,4-Diarylpiperidines as potent renin inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 1953-7. PMID 22325946 DOI: 10.1016/j.bmcl.2012.01.044  0.8
2012 Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, et al. Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series. Bioorganic & Medicinal Chemistry Letters. 22: 980-4. PMID 22209206 DOI: 10.1016/j.bmcl.2011.12.002  0.8
2012 Lachance N, Guiral S, Huang Z, Leclerc JP, Li CS, Oballa RM, Ramtohul YK, Wang H, Wu J, Zhang L. Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series. Bioorganic & Medicinal Chemistry Letters. 22: 623-7. PMID 22101133 DOI: 10.1016/j.bmcl.2011.10.070  0.8
2011 Leclerc JP, Falgueyret JP, Girardin M, Guay J, Guiral S, Huang Z, Li CS, Oballa R, Ramtohul YK, Skorey K, Tawa P, Wang H, Zhang L. Conversion of systemically-distributed triazole-based stearoyl-CoA desaturase (SCD) uHTS hits into liver-targeted SCD inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6505-9. PMID 21924609 DOI: 10.1016/j.bmcl.2011.08.073  0.8
2011 Ramtohul YK, Powell D, Leclerc JP, Leger S, Oballa R, Black C, Isabel E, Li CS, Crane S, Robichaud J, Guay J, Guiral S, Zhang L, Huang Z. Bicyclic heteroaryl inhibitors of stearoyl-CoA desaturase: from systemic to liver-targeting inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5692-6. PMID 21871798 DOI: 10.1016/j.bmcl.2011.08.037  0.8
2011 Oballa RM, Belair L, Black WC, Bleasby K, Chan CC, Desroches C, Du X, Gordon R, Guay J, Guiral S, Hafey MJ, Hamelin E, Huang Z, Kennedy B, Lachance N, ... ... Ramtohul YK, et al. Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. Journal of Medicinal Chemistry. 54: 5082-96. PMID 21661758 DOI: 10.1021/jm200319u  0.8
2010 Powell DA, Ramtohul Y, Lebrun ME, Oballa R, Bhat S, Falgueyret JP, Guiral S, Huang Z, Skorey K, Tawa P, Zhang L. 2-Aryl benzimidazoles: human SCD1-specific stearoyl coenzyme-A desaturase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 6366-9. PMID 20933412 DOI: 10.1016/j.bmcl.2010.09.094  0.8
2010 Ramtohul YK, Black C, Chan CC, Crane S, Guay J, Guiral S, Huang Z, Oballa R, Xu LJ, Zhang L, Li CS. SAR and optimization of thiazole analogs as potent stearoyl-CoA desaturase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 1593-7. PMID 20137926 DOI: 10.1016/j.bmcl.2010.01.083  0.8
2010 Zhang L, Ramtohul Y, Gagné S, Styhler A, Wang H, Guay J, Huang Z. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. Journal of Biomolecular Screening. 15: 169-76. PMID 20086206 DOI: 10.1177/1087057109356208  0.8
2009 Li CS, Belair L, Guay J, Murgasva R, Sturkenboom W, Ramtohul YK, Zhang L, Huang Z. Thiazole analog as stearoyl-CoA desaturase 1 inhibitor. Bioorganic & Medicinal Chemistry Letters. 19: 5214-7. PMID 19632834 DOI: 10.1016/j.bmcl.2009.07.015  0.8
2009 Giacometti RD, Ramtohul YK. Synthesis of polycyclic indolone and pyrroloindolone heterocycles via the annulation of indole- and pyrrole-2-carboxylate esters with arynes Synlett. 2010-2016. DOI: 10.1055/s-0029-1217535  0.8
2008 Krishnan S, Bagdanoff JT, Ebner DC, Ramtohul YK, Tambar UK, Stoltz BM. Pd-catalyzed enantioselective aerobic oxidation of secondary alcohols: applications to the total synthesis of alkaloids. Journal of the American Chemical Society. 130: 13745-54. PMID 18798630 DOI: 10.1021/ja804738b  0.8
2008 Blackburn T, Ramtohul YK. Synthesis of isoquinoline-3-carboxylates and benzocyclobutanes via reaction of 2-amidoacrylate esters with arynes Synlett. 1159-1164. DOI: 10.1055/s-2008-1072723  0.8
2007 Ramtohul YK, Chartrand A. Direct C-arylation of beta-enamino esters and ketones with arynes. Organic Letters. 9: 1029-32. PMID 17309270 DOI: 10.1021/ol063057k  0.8
2005 Trend RM, Ramtohul YK, Stoltz BM. Oxidative cyclizations in a nonpolar solvent using molecular oxygen and studies on the stereochemistry of oxypalladation. Journal of the American Chemical Society. 127: 17778-88. PMID 16351107 DOI: 10.1021/ja055534k  0.8
2003 Trend RM, Ramtohul YK, Ferreira EM, Stoltz BM. Palladium-catalyzed oxidative wacker cyclizations in nonpolar organic solvents with molecular oxygen: a stepping stone to asymmetric aerobic cyclizations. Angewandte Chemie (International Ed. in English). 42: 2892-5. PMID 12833351 DOI: 10.1002/anie.200351196  0.8
2002 Ramtohul YK, James MN, Vederas JC. Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase. The Journal of Organic Chemistry. 67: 3169-78. PMID 12003522 DOI: 10.1021/jo0157831  0.8
2002 Lall MS, Ramtohul YK, James MN, Vederas JC. Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. The Journal of Organic Chemistry. 67: 1536-47. PMID 11871884 DOI: 10.1021/jo0109016  0.8
2002 Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Synthesis of pseudoxazolones and their inhibition of the 3C cysteine proteinases from hepatitis A virus and human rhinovirus-14 Journal of the Chemical Society. Perkin Transactions 1. 1351-1359.  0.8
2001 Ramtohul YK, Martin NI, Silkin L, James MNG, Vederas JC. Pseudoxazolones, a new class of inhibitors for cysteine proteinases: Inhibition of hepatitis A virus and human rhinovirus 3C proteinases Chemical Communications. 2740-2741.  0.8
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