Derek S. Tan, PhD - Publications

Affiliations: 
2002- Chemical Biology Memorial Sloan Kettering Cancer Center, Rockville Centre, NY, United States 
Area:
organic synthesis, chemical biology
Website:
http://www.mskcc.org/tan

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kinarivala N, Standke LC, Guney T, Ji C, Noguchi N, Asano Y, Tan DS. Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes. Methods in Enzymology. 638: 69-87. PMID 32416922 DOI: 10.1016/bs.mie.2020.04.051  1
2019 Xu Y, Tan DS. Total Synthesis of the Bacterial Diisonitrile Chalkophore SF2768. Organic Letters. PMID 31633364 DOI: 10.1021/acs.orglett.9b03348  0.48
2019 Hann ZS, Ji C, Olsen SK, Lu X, Lux MC, Tan DS, Lima CD. Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235585 DOI: 10.1073/pnas.1905488116  1
2019 Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. Acs Chemical Biology. PMID 31083966 DOI: 10.1021/acschembio.9b00298  1
2019 Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS. Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry. PMID 30912442 DOI: 10.1021/acs.biochem.9b00003  1
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Tan DS, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/acscentsci.8b00747  1
2018 Bythrow GV, Mohandas P, Guney T, Standke LC, Germain GA, Lu X, Ji C, Levendosky K, Chavadi SS, Tan DS, Quadri LEN. Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents. Biochemistry. PMID 30582694 DOI: 10.1021/acs.biochem.8b01153  1
2018 Karimov RR, Tan DS, Gin DY. Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction. Tetrahedron. 74: 3370-3383. PMID 30467444 DOI: 10.1016/j.tet.2018.04.051  1
2018 Guney T, Wenderski TA, Boudreau MW, Tan DS. Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29936701 DOI: 10.1002/chem.201802880  1
2017 Verano AL, Tan DS. Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery. Israel Journal of Chemistry. 57: 279-291. PMID 29104308 DOI: 10.1002/ijch.201600134  1
2017 Verano AL, Tan DS. Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants. Chemical Science. 8: 3687-3693. PMID 28845229 DOI: 10.1039/c6sc05505b  1
2017 Karimov RR, Tan DS, Gin DY. Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C6F5)3-catalyzed glycosylation of sterically-hindered precursors. Chemical Communications (Cambridge, England). PMID 28498382 DOI: 10.1039/c7cc01783a  1
2017 Fernández-Tejada A, Walkowicz WE, Tan DS, Gin DY. Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21. Methods in Molecular Biology (Clifton, N.J.). 1494: 45-71. PMID 27718185 DOI: 10.1007/978-1-4939-6445-1_4  1
2016 Evans CE, Matarlo JS, Tonge PJ, Tan DS. Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics. Organic Letters. 18: 6384-6387. PMID 27978658 DOI: 10.1021/acs.orglett.6b03272  1
2016 Davis TD, Mohandas P, Chiriac MI, Bythrow GV, Quadri LE, Tan DS. Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorganic & Medicinal Chemistry Letters. PMID 27692545 DOI: 10.1016/j.bmcl.2016.09.027  1
2016 Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27658001 DOI: 10.1021/acschembio.6b00575  1
2016 Fernández-Tejada A, Tan DS, Gin DY. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Accounts of Chemical Research. PMID 27568877 DOI: 10.1021/acs.accounts.6b00242  1
2016 Walkowicz WE, Fernández-Tejada A, George C, Corzana F, Jiménez-Barbero J, Ragupathi G, Tan DS, Gin DY. Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chemical Science (Royal Society of Chemistry : 2010). 7: 2371-2380. PMID 27014435 DOI: 10.1039/C5SC02978C  1
2015 Vettore AL, Ramnarayanan K, Poore G, Lim K, Ong CK, Huang KK, Leong HS, Chong FT, Lim TK, Lim WK, Cutcutache I, Mcpherson JR, Suzuki Y, Zhang S, Skanthakumar T, ... ... Tan DS, et al. Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. Genome Medicine. 7: 98. PMID 26395002 DOI: 10.1186/s13073-015-0219-2  0.44
2015 Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ. Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents. Biochemistry. PMID 26394156 DOI: 10.1021/acs.biochem.5b00966  1
2015 Fernández-Tejada A, Tan DS, Gin DY. Correction: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical Communications (Cambridge, England). 51: 14410. PMID 26334089 DOI: 10.1039/c5cc90397a  1
2015 Stratton CF, Newman DJ, Tan DS. Cheminformatic comparison of approved drugs from natural product versus synthetic origins. Bioorganic & Medicinal Chemistry Letters. 25: 4802-7. PMID 26254944 DOI: 10.1016/j.bmcl.2015.07.014  1
2015 Fernández-Tejada A, Tan DS, Gin DY. Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical Communications (Cambridge, England). PMID 26243268 DOI: 10.1039/c5cc05244k  1
2015 Jain A, Lim C, Gan EM, Ng DZ, Ng QS, Ang MK, Takano A, Chan KS, Tan WM, Kanesvaran R, Toh CK, Loo CM, Hsu AA, Devanand A, Lim CH, ... ... Tan DS, et al. Impact of Smoking and Brain Metastasis on Outcomes of Advanced EGFR Mutation Lung Adenocarcinoma Patients Treated with First Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. Plos One. 10: e0123587. PMID 25955322 DOI: 10.1371/journal.pone.0123587  0.44
2015 Tan EH, Tan DS, Li WY, Haaland B, Ang MK, Chau NM, Toh CK, Tan IB, Koh TS, Thng CH, Chowbay B, Hui KM, Lim WT, Ng QS. Metronomic vinorelbine (oral) in combination with sorafenib in advanced non-small cell lung cancer. Lung Cancer (Amsterdam, Netherlands). 88: 289-96. PMID 25896396 DOI: 10.1016/j.lungcan.2015.04.001  0.44
2015 Tai WM, Lim C, Ahmad A, Ong WS, Choo SP, Lim WT, Tan EH, Kanesvaran R, Tan DS. Do elderly patients benefit from enrollment into Phase I Trials? Journal of Geriatric Oncology. 6: 241-8. PMID 25779876 DOI: 10.1016/j.jgo.2015.02.003  0.44
2015 Iyer NG, Tan DS, Tan VK, Wang W, Hwang J, Tan NC, Sivanandan R, Tan HK, Lim WT, Ang MK, Wee J, Soo KC, Tan EH. Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis. Cancer. 121: 1599-607. PMID 25639864 DOI: 10.1002/cncr.29251  0.44
2015 Wenderski TA, Stratton CF, Bauer RA, Kopp F, Tan DS. Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods in Molecular Biology (Clifton, N.J.). 1263: 225-42. PMID 25618349 DOI: 10.1007/978-1-4939-2269-7_18  1
2015 Wong AL, Soo RA, Tan DS, Lee SC, Lim JS, Marban PC, Kong LR, Lee YJ, Wang LZ, Thuya WL, Soong R, Yee MQ, Chin TM, Cordero MT, Asuncion BR, et al. Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 26: 998-1005. PMID 25609248 DOI: 10.1093/annonc/mdv026  0.44
2015 Wang W, Lim WK, Leong HS, Chong FT, Lim TK, Tan DS, Teh BT, Iyer NG. An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases. Oral Oncology. 51: 355-62. PMID 25560799 DOI: 10.1016/j.oraloncology.2014.12.012  0.44
2015 Stratton CF, Newman DJ, Tan DS. Cheminformatic comparison of approved drugs from natural product versus synthetic origins Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.07.014  1
2014 Fernández-Tejada A, Chea EK, George C, Gardner JR, Livingston PO, Ragupathi G, Tan DS, Gin DY. Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol. Bioorganic & Medicinal Chemistry. 22: 5917-23. PMID 25284254 DOI: 10.1016/j.bmc.2014.09.016  1
2014 Tan DS, Wang W, Leong HS, Sew PH, Lau DP, Chong FT, Krisna SS, Lim TK, Iyer NG. Tongue carcinoma infrequently harbor common actionable genetic alterations. Bmc Cancer. 14: 679. PMID 25234657 DOI: 10.1186/1471-2407-14-679  0.44
2014 Davis TD, Gerry CJ, Tan DS. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria. Acs Chemical Biology. 9: 2535-44. PMID 25198656 DOI: 10.1021/cb5003015  1
2014 Krishnan VG, Ebert PJ, Ting JC, Lim E, Wong SS, Teo AS, Yue YG, Chua HH, Ma X, Loh GS, Lin Y, Tan JH, Yu K, Zhang S, Reinhard C, ... Tan DS, et al. Whole-genome sequencing of asian lung cancers: second-hand smoke unlikely to be responsible for higher incidence of lung cancer among Asian never-smokers. Cancer Research. 74: 6071-81. PMID 25189529 DOI: 10.1158/0008-5472.CAN-13-3195  0.44
2014 Pla D, Tan DS, Gin DY. 5-(Methylthio)tetrazoles as Versatile Synthons in the Stereoselective Synthesis of Polycyclic Pyrazolines via Photoinduced Intramolecular Nitrile Imine-Alkene 1,3-Dipolar Cycloaddition. Chemical Science (Royal Society of Chemistry : 2010). 5: 2407-2415. PMID 25114776 DOI: 10.1039/C4SC00107A  1
2014 Leong HS, Chong FT, Sew PH, Lau DP, Wong BH, Teh BT, Tan DS, Iyer NG. Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer. Stem Cells Translational Medicine. 3: 1055-65. PMID 25024430 DOI: 10.5966/sctm.2013-0214  0.44
2014 Khoo BL, Warkiani ME, Tan DS, Bhagat AA, Irwin D, Lau DP, Lim AS, Lim KH, Krisna SS, Lim WT, Yap YS, Lee SC, Soo RA, Han J, Lim CT. Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells. Plos One. 9: e99409. PMID 24999991 DOI: 10.1371/journal.pone.0099409  0.44
2014 Ang SH, Haaland B, Acharyya S, Thu MM, Krisna SS, Hwang SG, Tan PH, Ng QS, Tan DS, Tai WM, Tan EH, Lim WT, Ang MK. Interactions between clinical factors, p16, and cyclin-D1 expression and survival outcomes in oropharyngeal and hypopharyngeal squamous cell carcinoma. Head & Neck. PMID 24953865 DOI: 10.1002/hed.23803  0.44
2014 Fernández-Tejada A, Chea EK, George C, Pillarsetty N, Gardner JR, Livingston PO, Ragupathi G, Lewis JS, Tan DS, Gin DY. Development of a minimal saponin vaccine adjuvant based on QS-21. Nature Chemistry. 6: 635-43. PMID 24950335 DOI: 10.1038/nchem.1963  1
2014 Warkiani ME, Khoo BL, Tan DS, Bhagat AA, Lim WT, Yap YS, Lee SC, Soo RA, Han J, Lim CT. An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells. The Analyst. 139: 3245-55. PMID 24840240 DOI: 10.1039/c4an00355a  0.44
2014 Sharma I, Wurst JM, Tan DS. Solvent-dependent divergent functions of Sc(OTf)₃ in stereoselective epoxide-opening spiroketalizations. Organic Letters. 16: 2474-7. PMID 24742081 DOI: 10.1021/ol500853q  1
2014 Tan DS, Camilleri-Broët S, Tan EH, Alifano M, Lim WT, Bobbio A, Zhang S, Ng QS, Ang MK, Iyer NG, Takano A, Lim KH, Régnard JF, Tan P, Broët P. Intertumor heterogeneity of non-small-cell lung carcinomas revealed by multiplexed mutation profiling and integrative genomics. International Journal of Cancer. Journal International Du Cancer. 135: 1092-100. PMID 24482041 DOI: 10.1002/ijc.28750  0.44
2014 Tan DS, Haaland B, Gan JM, Tham SC, Sinha I, Tan EH, Lim KH, Takano A, Krisna SS, Thu MM, Liew HP, Ullrich A, Lim WT, Chua BT. Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer. Molecular Cancer. 13: 13. PMID 24461128 DOI: 10.1186/1476-4598-13-13  0.44
2014 Warkiani ME, Guan G, Luan KB, Lee WC, Bhagat AA, Chaudhuri PK, Tan DS, Lim WT, Lee SC, Chen PC, Lim CT, Han J. Slanted spiral microfluidics for the ultra-fast, label-free isolation of circulating tumor cells. Lab On a Chip. 14: 128-37. PMID 23949794 DOI: 10.1039/c3lc50617g  0.44
2014 Qi LK, Lin L, Chen DL, Tan DS. Fingerprint of the litchi honey by Raman spectroscopic Modern Food Science and Technology. 30: 201-205.  0.32
2013 Shi Y, Wilmot JT, Nordstrøm LU, Tan DS, Gin DY. Total synthesis, relay synthesis, and structural confirmation of the C18-norditerpenoid alkaloid neofinaconitine. Journal of the American Chemical Society. 135: 14313-20. PMID 24040959 DOI: 10.1021/ja4064958  1
2013 Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrobial Agents and Chemotherapy. 57: 5138-40. PMID 23856770 DOI: 10.1128/AAC.00918-13  1
2013 Yeang MS, Tay K, Ong WS, Thiagarajan A, Tan DS, Ha TC, Teo PT, Soo KC, Tan HK, Iyer NG. Outcomes and prognostic factors of post-irradiation and de novo sarcomas of the head and neck: a histologically matched case-control study. Annals of Surgical Oncology. 20: 3066-75. PMID 23604715 DOI: 10.1245/s10434-013-2979-5  0.44
2013 Tan DS, Montoya J, Ng QS, Chan KS, Lynette O, Sakktee Krisna S, Takano A, Lim WT, Tan EH, Lim KH. Molecular profiling for druggable genetic abnormalities in carcinoma of unknown primary. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: e237-9. PMID 23547070 DOI: 10.1200/JCO.2012.44.3937  0.44
2013 Sharma I, Tan DS. Drug discovery: Diversifying complexity. Nature Chemistry. 5: 157-8. PMID 23422555 DOI: 10.1038/nchem.1581  1
2013 Hou HW, Warkiani ME, Khoo BL, Li ZR, Soo RA, Tan DS, Lim WT, Han J, Bhagat AA, Lim CT. Isolation and retrieval of circulating tumor cells using centrifugal forces. Scientific Reports. 3: 1259. PMID 23405273 DOI: 10.1038/srep01259  0.44
2013 Bauer RA, Wenderski TA, Tan DS. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nature Chemical Biology. 9: 21-9. PMID 23160003 DOI: 10.1038/nchembio.1130  1
2012 Wurst JM, Verano AL, Tan DS. Stereoselective synthesis of acortatarins A and B. Organic Letters. 14: 4442-5. PMID 22924668 DOI: 10.1021/ol3019456  1
2012 Yap TA, Cortes-Funes H, Shaw H, Rodriguez R, Olmos D, Lal R, Fong PC, Tan DS, Harris D, Capdevila J, Coronado C, Alfaro V, Soto-Matos A, Fernández-Teruel C, Siguero M, et al. First-in-man phase I trial of two schedules of the novel synthetic tetrahydroisoquinoline alkaloid PM00104 (Zalypsis) in patients with advanced solid tumours. British Journal of Cancer. 106: 1379-85. PMID 22491421 DOI: 10.1038/bjc.2012.99  0.44
2012 Ng KP, Hillmer AM, Chuah CT, Juan WC, Ko TK, Teo AS, Ariyaratne PN, Takahashi N, Sawada K, Fei Y, Soh S, Lee WH, Huang JW, Allen JC, Woo XY, ... ... Tan DS, et al. A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. Nature Medicine. 18: 521-8. PMID 22426421 DOI: 10.1038/nm.2713  0.44
2012 Kopp F, Stratton CF, Akella LB, Tan DS. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion. Nature Chemical Biology. 8: 358-65. PMID 22406518 DOI: 10.1038/nchembio.911  1
2012 Lu X, Zhou R, Sharma I, Li X, Kumar G, Swaminathan S, Tonge PJ, Tan DS. Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem : a European Journal of Chemical Biology. 13: 129-36. PMID 22109989 DOI: 10.1002/cbic.201100585  1
2012 Tan EH, Goh C, Lim WT, Soo KC, Khoo ML, Tan T, Tan DS, Ang MK, Ng QS, Tan PH, Lim A, Hwang J, Teng YH, Lim TH, Tan SH, et al. Gefitinib, cisplatin, and concurrent radiotherapy for locally advanced head and neck cancer: EGFR FISH, protein expression, and mutational status are not predictive biomarkers. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 23: 1010-6. PMID 21768327 DOI: 10.1093/annonc/mdr327  0.44
2012 Ng QS, Thng CH, Lim WT, Hartono S, Thian YL, Lee PS, Tan DS, Tan EH, Koh TS. Dynamic contrast-enhanced computed tomography in metastatic nasopharyngeal carcinoma: reproducibility analysis and observer variability of the distributed parameter model. Investigative Radiology. 47: 5-10. PMID 21577128 DOI: 10.1097/RLI.0b013e3182199b9a  0.44
2012 Kim S, Cao X, Zhang H, Tan DS. Enabling concurrent dual views on common LCD screens Conference On Human Factors in Computing Systems - Proceedings. 2175-2184. DOI: 10.1145/2207676.2208369  1
2011 Lim WT, Ng QS, Ivy P, Leong SS, Singh O, Chowbay B, Gao F, Thng CH, Goh BC, Tan DS, Koh TS, Toh CK, Tan EH. A Phase II study of pazopanib in Asian patients with recurrent/metastatic nasopharyngeal carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 5481-9. PMID 21712450 DOI: 10.1158/1078-0432.CCR-10-3409  0.44
2011 Koo YX, Tan DS, Tan IB, Tai DW, Ha T, Ong WS, Quek R, Tao M, Lim ST. Effect of concomitant statin, metformin, or aspirin on rituximab treatment for diffuse large B-cell lymphoma. Leukemia & Lymphoma. 52: 1509-16. PMID 21651435 DOI: 10.3109/10428194.2011.574752  0.44
2011 Wurst JM, Liu G, Tan DS. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals. Journal of the American Chemical Society. 133: 7916-25. PMID 21539313 DOI: 10.1021/ja201249c  1
2011 Moura-Letts G, Diblasi CM, Bauer RA, Tan DS. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proceedings of the National Academy of Sciences of the United States of America. 108: 6745-50. PMID 21451137 DOI: 10.1073/pnas.1015268108  1
2010 Olmos D, Tan DS, Jones RL, Judson IR. Biological rationale and current clinical experience with anti-insulin-like growth factor 1 receptor monoclonal antibodies in treating sarcoma: twenty years from the bench to the bedside. Cancer Journal (Sudbury, Mass.). 16: 183-94. PMID 20526094 DOI: 10.1097/PPO.0b013e3181dbebf9  0.44
2010 Bauer RA, DiBlasi CM, Tan DS. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Organic Letters. 12: 2084-7. PMID 20356070 DOI: 10.1021/ol100574y  1
2010 Bauer RA, Wurst JM, Tan DS. Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Current Opinion in Chemical Biology. 14: 308-14. PMID 20202892 DOI: 10.1016/j.cbpa.2010.02.001  1
2010 Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 463: 906-12. PMID 20164921 DOI: 10.1038/nature08765  1
2010 Lu X, Olsen SK, Capili AD, Cisar JS, Lima CD, Tan DS. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. Journal of the American Chemical Society. 132: 1748-9. PMID 20099854 DOI: 10.1021/ja9088549  1
2009 Tan DS, Thomas GV, Garrett MD, Banerji U, de Bono JS, Kaye SB, Workman P. Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development. Cancer Journal (Sudbury, Mass.). 15: 406-20. PMID 19826361 DOI: 10.1097/PPO.0b013e3181bd0445  0.44
2009 Liu G, Wurst JM, Tan DS. Stereoselective synthesis of benzannulated spiroketals: influence of the aromatic ring on reactivity and conformation. Organic Letters. 11: 3670-3. PMID 19634891 DOI: 10.1021/ol901437f  1
2008 Lu X, Zhang H, Tonge PJ, Tan DS. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorganic & Medicinal Chemistry Letters. 18: 5963-6. PMID 18762421 DOI: 10.1016/j.bmcl.2008.07.130  1
2008 Cisar JS, Tan DS. Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chemical Society Reviews. 37: 1320-9. PMID 18568158 DOI: 10.1039/b702780j  1
2008 Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chemistry & Biology. 15: 51-61. PMID 18158259 DOI: 10.1016/j.chembiol.2007.11.010  1
2007 Cisar JS, Ferreras JA, Soni RK, Quadri LE, Tan DS. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. Journal of the American Chemical Society. 129: 7752-3. PMID 17542590 DOI: 10.1021/ja0721521  1
2007 Shang S, Iwadare H, Macks DE, Ambrosini LM, Tan DS. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Organic Letters. 9: 1895-8. PMID 17439132 DOI: 10.1021/ol070405p  1
2007 Hua ZS, Zhang B, Yang J, Tan DS. A new approach of forecasting intermittent demand for spare parts inventories in the process industries Journal of the Operational Research Society. 58: 52-61. DOI: 10.1057/palgrave.jors.2602119  0.52
2006 Moilanen SB, Potuzak JS, Tan DS. Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. Journal of the American Chemical Society. 128: 1792-3. PMID 16464069 DOI: 10.1021/ja057908f  1
2005 Tan DS. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nature Chemical Biology. 1: 74-84. PMID 16408003 DOI: 10.1038/nchembio0705-74  1
2005 Ferreras JA, Ryu JS, Di Lello F, Tan DS, Quadri LE. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nature Chemical Biology. 1: 29-32. PMID 16407990 DOI: 10.1038/nchembio706  1
2005 Mandal M, Yun H, Dudley GB, Lin S, Tan DS, Danishefsky SJ. Total synthesis of guanacastepene a: a route to enantiomeric control. The Journal of Organic Chemistry. 70: 10619-37. PMID 16355979 DOI: 10.1021/jo051470k  1
2005 Potuzak JS, Moilanen SB, Tan DS. Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. Journal of the American Chemical Society. 127: 13796-7. PMID 16201793 DOI: 10.1021/ja055033z  1
2005 Shang S, Tan DS. Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Current Opinion in Chemical Biology. 9: 248-58. PMID 15939326 DOI: 10.1016/j.cbpa.2005.03.006  1
2005 Diblasi CM, Macks DE, Tan DS. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Organic Letters. 7: 1777-80. PMID 15844904 DOI: 10.1021/ol050370y  1
2005 Moilanen SB, Tan DS. Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: new insights into glycal reactivity. Organic & Biomolecular Chemistry. 3: 798-803. PMID 15731865 DOI: 10.1039/b417429a  1
2004 Potuzak JS, Moilanen SB, Tan DS. Discovery and applications of small molecule probes for studying biological processes. Biotechnology & Genetic Engineering Reviews. 21: 11-78. PMID 17017027  1
2004 Tan DS. Current progress in natural product-like libraries for discovery screening. Combinatorial Chemistry & High Throughput Screening. 7: 631-43. PMID 15578925  1
2004 Potuzak JS, Tan DS. Synthesis of C1-alkyl- and acylglycals from glycals using a B-alkyl Suzuki-Miyaura cross coupling approach Tetrahedron Letters. 45: 1797-1801. DOI: 10.1016/j.tetlet.2003.12.006  1
2002 Lin S, Dudley GB, Tan DS, Danishefsky SJ. A stereoselective route to guanacastepene A through a surprising epoxidation. Angewandte Chemie (International Ed. in English). 41: 2188-91. PMID 19746640 DOI: 10.1002/1521-3773(20020617)41:12<2188::AID-ANIE2188>3.0.CO;2-J  1
2002 Tan DS, Dudley GB, Danishefsky SJ. Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization. Angewandte Chemie (International Ed. in English). 41: 2185-8. PMID 19746639 DOI: 10.1002/1521-3773(20020617)41:12<2185::AID-ANIE2185>3.0.CO;2-0  1
2002 Tan DS. Sweet surrender to chemical genetics. Nature Biotechnology. 20: 561-3. PMID 12042857 DOI: 10.1038/nbt0602-561  1
2002 Lin S, Dudley GB, Tan DS, Danishefsky SJ. A Stereoselective Route to Guanacastepene A through a Surprising Epoxidation This work was supported by the National Institutes of Health (CA-28824). S.L. is a US Army breast cancer research program postdoctoral fellow (DAMD-17-99-1-9373). G.B.D. is an NIH postdoctoral fellow (1 F32 NS11150-01). D.S.T. is a Damon Runyon Cancer Research Foundation postdoctoral fellow (DRG-1641). We thank Dr. George Sukenick and Sylvi Rusli (NMR Core Facility, CA-02848) for mass spectral analyses. Angewandte Chemie International Edition. 41: 2188. DOI: 10.1002/1521-3773(20020617)41:12<2188::AID-ANIE2188>3.0.CO;2-J  1
2002 Tan DS, Dudley GB, Danishefsky SJ. Synthesis of the Functionalized Tricyclic Skeleton of Guanacastepene A: A Tandem Epoxide-Opening β-Elimination/Knoevenagel Cyclization This work was supported by the National Institutes of Health (HL-25848 and CA-28824). D.S.T. is a Damon Runyon Cancer Research Foundation postdoctoral fellow (DRG-1641). G.B.D. is an NIH postdoctoral fellow (1 F32 NS11150-01). We thank Dr. George Sukenick and Sylvi Rusli (NMR Core Facility, CA-02848) for mass spectral analyses. Angewandte Chemie International Edition. 41: 2185. DOI: 10.1002/1521-3773(20020617)41:12<2185::AID-ANIE2185>3.0.CO;2-0  1
2001 Dudley GB, Tan DS, Kim G, Tanski JM, Danishefsky SJ. Remarkable stereoselectivity in the alkylation of a hydroazulenone: Progress towards the total synthesis of guanacastepene Tetrahedron Letters. 42: 6789-6791. DOI: 10.1016/S0040-4039(01)01342-9  1
2000 Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275. DOI: 10.1021/ja992144n  1
1998 Tan DS, Foley MA, Shair MD, Schreiber SL. Stereoselective synthesis of over two million compounds having structural features both reminiscent of natural products and compatible with miniaturized cell-based assays [25] Journal of the American Chemical Society. 120: 8565-8566. DOI: 10.1021/ja981746o  1
1995 Tan DS, Günter MM, Drueckhammer DG. Enzymatic resolution coupled with substrate racemization using a thioester substrate Journal of the American Chemical Society. 117: 9093-9094. DOI: 10.1021/ja00140a037  1
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