Derek S. Tan, PhD - Publications

Affiliations: 
2002- Chemical Biology Memorial Sloan Kettering Cancer Center, Rockville Centre, NY, United States 
Area:
organic synthesis, chemical biology
Website:
http://www.mskcc.org/tan

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hann ZS, Ji C, Olsen SK, Lu X, Lux MC, Tan DS, Lima CD. Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31235585 DOI: 10.1073/pnas.1905488116  1
2019 Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. Acs Chemical Biology. PMID 31083966 DOI: 10.1021/acschembio.9b00298  1
2019 Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS. Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE. Biochemistry. PMID 30912442 DOI: 10.1021/acs.biochem.9b00003  1
2018 Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, ... ... Tan DS, et al. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. Acs Central Science. 4: 1727-1741. PMID 30648156 DOI: 10.1021/acscentsci.8b00747  1
2018 Bythrow GV, Mohandas P, Guney T, Standke LC, Germain GA, Lu X, Ji C, Levendosky K, Chavadi SS, Tan DS, Quadri LEN. Kinetic Analyses of the Siderophore Biosynthesis Inhibitor Salicyl-AMS and Analogues as MbtA Inhibitors and Antimycobacterial Agents. Biochemistry. PMID 30582694 DOI: 10.1021/acs.biochem.8b01153  1
2018 Karimov RR, Tan DS, Gin DY. Synthesis of the hexacyclic triterpene core of the jujuboside saponins via tandem Wolff rearrangement-intramolecular ketene hetero-Diels-Alder reaction. Tetrahedron. 74: 3370-3383. PMID 30467444 DOI: 10.1016/j.tet.2018.04.051  1
2018 Guney T, Wenderski TA, Boudreau MW, Tan DS. Synthesis of Benzannulated Medium-ring Lactams via a Tandem Oxidative Dearomatization-Ring Expansion Reaction. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29936701 DOI: 10.1002/chem.201802880  1
2017 Verano AL, Tan DS. Stereocontrolled Synthesis of Spiroketals: An Engine for Chemical and Biological Discovery. Israel Journal of Chemistry. 57: 279-291. PMID 29104308 DOI: 10.1002/ijch.201600134  1
2017 Verano AL, Tan DS. Family-level stereoselective synthesis and biological evaluation of pyrrolomorpholine spiroketal natural product antioxidants. Chemical Science. 8: 3687-3693. PMID 28845229 DOI: 10.1039/c6sc05505b  1
2017 Karimov RR, Tan DS, Gin DY. Rapid assembly of the doubly-branched pentasaccharide domain of the immunoadjuvant jujuboside A via convergent B(C6F5)3-catalyzed glycosylation of sterically-hindered precursors. Chemical Communications (Cambridge, England). PMID 28498382 DOI: 10.1039/c7cc01783a  1
2017 Fernández-Tejada A, Walkowicz WE, Tan DS, Gin DY. Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21. Methods in Molecular Biology (Clifton, N.J.). 1494: 45-71. PMID 27718185 DOI: 10.1007/978-1-4939-6445-1_4  1
2016 Evans CE, Matarlo JS, Tonge PJ, Tan DS. Stereoselective Synthesis, Docking, and Biological Evaluation of Difluoroindanediol-Based MenE Inhibitors as Antibiotics. Organic Letters. 18: 6384-6387. PMID 27978658 DOI: 10.1021/acs.orglett.6b03272  1
2016 Davis TD, Mohandas P, Chiriac MI, Bythrow GV, Quadri LE, Tan DS. Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes. Bioorganic & Medicinal Chemistry Letters. PMID 27692545 DOI: 10.1016/j.bmcl.2016.09.027  1
2016 Ji C, Sharma I, Pratihar D, Hudson LL, Maura D, Guney T, Rahme LG, Pesci EC, Coleman JP, Tan DS. Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa. Acs Chemical Biology. PMID 27658001 DOI: 10.1021/acschembio.6b00575  1
2016 Fernández-Tejada A, Tan DS, Gin DY. Development of Improved Vaccine Adjuvants Based on the Saponin Natural Product QS-21 through Chemical Synthesis. Accounts of Chemical Research. PMID 27568877 DOI: 10.1021/acs.accounts.6b00242  1
2016 Walkowicz WE, Fernández-Tejada A, George C, Corzana F, Jiménez-Barbero J, Ragupathi G, Tan DS, Gin DY. Quillaja Saponin Variants with Central Glycosidic Linkage Modifications Exhibit Distinct Conformations and Adjuvant Activities. Chemical Science (Royal Society of Chemistry : 2010). 7: 2371-2380. PMID 27014435 DOI: 10.1039/C5SC02978C  1
2015 Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ. Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents. Biochemistry. PMID 26394156 DOI: 10.1021/acs.biochem.5b00966  1
2015 Fernández-Tejada A, Tan DS, Gin DY. Correction: Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical Communications (Cambridge, England). 51: 14410. PMID 26334089 DOI: 10.1039/c5cc90397a  1
2015 Stratton CF, Newman DJ, Tan DS. Cheminformatic comparison of approved drugs from natural product versus synthetic origins. Bioorganic & Medicinal Chemistry Letters. 25: 4802-7. PMID 26254944 DOI: 10.1016/j.bmcl.2015.07.014  1
2015 Fernández-Tejada A, Tan DS, Gin DY. Versatile strategy for the divergent synthesis of linear oligosaccharide domain variants of Quillaja saponin vaccine adjuvants. Chemical Communications (Cambridge, England). PMID 26243268 DOI: 10.1039/c5cc05244k  1
2015 Wenderski TA, Stratton CF, Bauer RA, Kopp F, Tan DS. Principal component analysis as a tool for library design: a case study investigating natural products, brand-name drugs, natural product-like libraries, and drug-like libraries. Methods in Molecular Biology (Clifton, N.J.). 1263: 225-42. PMID 25618349 DOI: 10.1007/978-1-4939-2269-7_18  1
2015 Stratton CF, Newman DJ, Tan DS. Cheminformatic comparison of approved drugs from natural product versus synthetic origins Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.07.014  1
2014 Fernández-Tejada A, Chea EK, George C, Gardner JR, Livingston PO, Ragupathi G, Tan DS, Gin DY. Design, synthesis, and immunologic evaluation of vaccine adjuvant conjugates based on QS-21 and tucaresol. Bioorganic & Medicinal Chemistry. 22: 5917-23. PMID 25284254 DOI: 10.1016/j.bmc.2014.09.016  1
2014 Davis TD, Gerry CJ, Tan DS. General platform for systematic quantitative evaluation of small-molecule permeability in bacteria. Acs Chemical Biology. 9: 2535-44. PMID 25198656 DOI: 10.1021/cb5003015  1
2014 Pla D, Tan DS, Gin DY. 5-(Methylthio)tetrazoles as Versatile Synthons in the Stereoselective Synthesis of Polycyclic Pyrazolines via Photoinduced Intramolecular Nitrile Imine-Alkene 1,3-Dipolar Cycloaddition. Chemical Science (Royal Society of Chemistry : 2010). 5: 2407-2415. PMID 25114776 DOI: 10.1039/C4SC00107A  1
2014 Fernández-Tejada A, Chea EK, George C, Pillarsetty N, Gardner JR, Livingston PO, Ragupathi G, Lewis JS, Tan DS, Gin DY. Development of a minimal saponin vaccine adjuvant based on QS-21. Nature Chemistry. 6: 635-43. PMID 24950335 DOI: 10.1038/nchem.1963  1
2014 Sharma I, Wurst JM, Tan DS. Solvent-dependent divergent functions of Sc(OTf)₃ in stereoselective epoxide-opening spiroketalizations. Organic Letters. 16: 2474-7. PMID 24742081 DOI: 10.1021/ol500853q  1
2014 Gergle D, Tan DS. Experimental research in HCI Ways of Knowing in Hci. 191-227. DOI: 10.1007/978-1-4939-0378-8_9  0.48
2013 Shi Y, Wilmot JT, Nordstrøm LU, Tan DS, Gin DY. Total synthesis, relay synthesis, and structural confirmation of the C18-norditerpenoid alkaloid neofinaconitine. Journal of the American Chemical Society. 135: 14313-20. PMID 24040959 DOI: 10.1021/ja4064958  1
2013 Lun S, Guo H, Adamson J, Cisar JS, Davis TD, Chavadi SS, Warren JD, Quadri LE, Tan DS, Bishai WR. Pharmacokinetic and in vivo efficacy studies of the mycobactin biosynthesis inhibitor salicyl-AMS in mice. Antimicrobial Agents and Chemotherapy. 57: 5138-40. PMID 23856770 DOI: 10.1128/AAC.00918-13  1
2013 Sharma I, Tan DS. Drug discovery: Diversifying complexity. Nature Chemistry. 5: 157-8. PMID 23422555 DOI: 10.1038/nchem.1581  1
2013 Bauer RA, Wenderski TA, Tan DS. Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion. Nature Chemical Biology. 9: 21-9. PMID 23160003 DOI: 10.1038/nchembio.1130  1
2013 Mujibiya A, Cao X, Tan DS, Morris D, Patel SN, Rekimoto J. The sound of touch: On-body touch and gesture sensing based on transdermal ultrasound propagation Its 2013 - Proceedings of the 2013 Acm International Conference On Interactive Tabletops and Surfaces. 189-198. DOI: 10.1145/2512349.2512821  0.48
2013 Adar E, Tan DS, Teevan J. Benevolent deception in human computer interaction Conference On Human Factors in Computing Systems - Proceedings. 1863-1872. DOI: 10.1145/2470654.2466246  0.48
2012 Wurst JM, Verano AL, Tan DS. Stereoselective synthesis of acortatarins A and B. Organic Letters. 14: 4442-5. PMID 22924668 DOI: 10.1021/ol3019456  1
2012 Kopp F, Stratton CF, Akella LB, Tan DS. A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion. Nature Chemical Biology. 8: 358-65. PMID 22406518 DOI: 10.1038/nchembio.911  1
2012 Lu X, Zhou R, Sharma I, Li X, Kumar G, Swaminathan S, Tonge PJ, Tan DS. Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis. Chembiochem : a European Journal of Chemical Biology. 13: 129-36. PMID 22109989 DOI: 10.1002/cbic.201100585  1
2012 Cohn G, Gupta S, Lee TJ, Morris D, Smith JR, Reynolds MS, Tan DS, Patel SN. An ultra-low-power human body motion sensor using static electric field sensing Ubicomp'12 - Proceedings of the 2012 Acm Conference On Ubiquitous Computing. 99-102. DOI: 10.1145/2370216.2370233  0.48
2012 Vardoulakis LP, Karlson AK, Morris D, Smith G, Gatewood J, Tan DS. Using mobile phones to present medical information to hospital patients Conference On Human Factors in Computing Systems - Proceedings. 1411-1420. DOI: 10.1145/2207676.2208601  0.48
2012 Kim S, Cao X, Zhang H, Tan DS. Enabling concurrent dual views on common LCD screens Conference On Human Factors in Computing Systems - Proceedings. 2175-2184. DOI: 10.1145/2207676.2208369  0.48
2012 Cohn G, Morris D, Patel SN, Tan DS. Humantenna: Using the body as an antenna for real-time whole-body interaction Conference On Human Factors in Computing Systems - Proceedings. 1901-1910. DOI: 10.1145/2207676.2208330  0.48
2011 Wurst JM, Liu G, Tan DS. Hydrogen-bonding catalysis and inhibition by simple solvents in the stereoselective kinetic epoxide-opening spirocyclization of glycal epoxides to form spiroketals. Journal of the American Chemical Society. 133: 7916-25. PMID 21539313 DOI: 10.1021/ja201249c  1
2011 Moura-Letts G, Diblasi CM, Bauer RA, Tan DS. Solid-phase synthesis and chemical space analysis of a 190-membered alkaloid/terpenoid-like library. Proceedings of the National Academy of Sciences of the United States of America. 108: 6745-50. PMID 21451137 DOI: 10.1073/pnas.1015268108  1
2010 Wilcox LG, Gatewood J, Morris D, Tan DS, Feiner S, Horvitz E. Physician Attitudes about Patient-Facing Information Displays at an Urban Emergency Department. Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 2010: 887-91. PMID 21347106  0.48
2010 Bauer RA, DiBlasi CM, Tan DS. The tert-butylsulfinamide lynchpin in transition-metal-mediated multiscaffold library synthesis. Organic Letters. 12: 2084-7. PMID 20356070 DOI: 10.1021/ol100574y  1
2010 Bauer RA, Wurst JM, Tan DS. Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective. Current Opinion in Chemical Biology. 14: 308-14. PMID 20202892 DOI: 10.1016/j.cbpa.2010.02.001  1
2010 Olsen SK, Capili AD, Lu X, Tan DS, Lima CD. Active site remodelling accompanies thioester bond formation in the SUMO E1. Nature. 463: 906-12. PMID 20164921 DOI: 10.1038/nature08765  1
2010 Lu X, Olsen SK, Capili AD, Cisar JS, Lima CD, Tan DS. Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes. Journal of the American Chemical Society. 132: 1748-9. PMID 20099854 DOI: 10.1021/ja9088549  1
2009 Liu G, Wurst JM, Tan DS. Stereoselective synthesis of benzannulated spiroketals: influence of the aromatic ring on reactivity and conformation. Organic Letters. 11: 3670-3. PMID 19634891 DOI: 10.1021/ol901437f  1
2008 Lu X, Zhang H, Tonge PJ, Tan DS. Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis. Bioorganic & Medicinal Chemistry Letters. 18: 5963-6. PMID 18762421 DOI: 10.1016/j.bmcl.2008.07.130  1
2008 Cisar JS, Tan DS. Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy. Chemical Society Reviews. 37: 1320-9. PMID 18568158 DOI: 10.1039/b702780j  1
2008 Ferreras JA, Stirrett KL, Lu X, Ryu JS, Soll CE, Tan DS, Quadri LE. Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chemistry & Biology. 15: 51-61. PMID 18158259 DOI: 10.1016/j.chembiol.2007.11.010  1
2007 Cisar JS, Ferreras JA, Soni RK, Quadri LE, Tan DS. Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. Journal of the American Chemical Society. 129: 7752-3. PMID 17542590 DOI: 10.1021/ja0721521  1
2007 Shang S, Iwadare H, Macks DE, Ambrosini LM, Tan DS. A unified synthetic approach to polyketides having both skeletal and stereochemical diversity. Organic Letters. 9: 1895-8. PMID 17439132 DOI: 10.1021/ol070405p  1
2006 Moilanen SB, Potuzak JS, Tan DS. Stereocontrolled synthesis of spiroketals via Ti(Oi-Pr)4-mediated kinetic spirocyclization of glycal epoxides with retention of configuration. Journal of the American Chemical Society. 128: 1792-3. PMID 16464069 DOI: 10.1021/ja057908f  1
2005 Tan DS. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nature Chemical Biology. 1: 74-84. PMID 16408003 DOI: 10.1038/nchembio0705-74  1
2005 Ferreras JA, Ryu JS, Di Lello F, Tan DS, Quadri LE. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nature Chemical Biology. 1: 29-32. PMID 16407990 DOI: 10.1038/nchembio706  1
2005 Mandal M, Yun H, Dudley GB, Lin S, Tan DS, Danishefsky SJ. Total synthesis of guanacastepene a: a route to enantiomeric control. The Journal of Organic Chemistry. 70: 10619-37. PMID 16355979 DOI: 10.1021/jo051470k  1
2005 Potuzak JS, Moilanen SB, Tan DS. Stereocontrolled synthesis of spiroketals via a remarkable methanol-induced kinetic spirocyclization reaction. Journal of the American Chemical Society. 127: 13796-7. PMID 16201793 DOI: 10.1021/ja055033z  1
2005 Shang S, Tan DS. Advancing chemistry and biology through diversity-oriented synthesis of natural product-like libraries. Current Opinion in Chemical Biology. 9: 248-58. PMID 15939326 DOI: 10.1016/j.cbpa.2005.03.006  1
2005 Diblasi CM, Macks DE, Tan DS. An acid-stable tert-butyldiarylsilyl (TBDAS) linker for solid-phase organic synthesis. Organic Letters. 7: 1777-80. PMID 15844904 DOI: 10.1021/ol050370y  1
2005 Moilanen SB, Tan DS. Enantioselective synthesis of erythro-4-deoxyglycals as scaffolds for target- and diversity-oriented synthesis: new insights into glycal reactivity. Organic & Biomolecular Chemistry. 3: 798-803. PMID 15731865 DOI: 10.1039/b417429a  1
2004 Potuzak JS, Moilanen SB, Tan DS. Discovery and applications of small molecule probes for studying biological processes. Biotechnology & Genetic Engineering Reviews. 21: 11-78. PMID 17017027  1
2004 Tan DS. Current progress in natural product-like libraries for discovery screening. Combinatorial Chemistry & High Throughput Screening. 7: 631-43. PMID 15578925  1
2002 Lin S, Dudley GB, Tan DS, Danishefsky SJ. A stereoselective route to guanacastepene A through a surprising epoxidation. Angewandte Chemie (International Ed. in English). 41: 2188-91. PMID 19746640 DOI: 10.1002/1521-3773(20020617)41:12<2188::AID-ANIE2188>3.0.CO;2-J  1
2002 Tan DS, Dudley GB, Danishefsky SJ. Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization. Angewandte Chemie (International Ed. in English). 41: 2185-8. PMID 19746639 DOI: 10.1002/1521-3773(20020617)41:12<2185::AID-ANIE2185>3.0.CO;2-0  1
2002 Tan DS. Sweet surrender to chemical genetics. Nature Biotechnology. 20: 561-3. PMID 12042857 DOI: 10.1038/nbt0602-561  1
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