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Todd L. Lowary, Ph.D. - Related publications

Affiliations: 
1996-2002 Chemistry Ohio State University, Columbus, Columbus, OH 
 2003- Chemistry University of Alberta, Edmonton, Alberta, Canada 
Area:
Glycobiology
Website:
http://www.chem.ualberta.ca/~lowary/
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Kumar S, Gupta Y, Zak SE, Upadhyay C, Sharma N, Herbert AS, Durvasula R, Potemkin V, Dye JM, Poonam, Kempaiah P, Rathi B. A novel compound active against SARS-CoV-2 targeting uridylate-specific endoribonuclease (NendoU/NSP15): and investigations. Rsc Medicinal Chemistry. 12: 1757-1764. PMID 34778776 DOI: 10.1039/d1md00202c   
2021 Campomizzi CS, Ghanatios GE, Estrada DF. F-NMR reveals substrate specificity of CYP121A1 in Mycobacterium tuberculosis. The Journal of Biological Chemistry. 101287. PMID 34634307 DOI: 10.1016/j.jbc.2021.101287   
2021 Legru A, Verdirosa F, Hernandez JF, Tassone G, Sannio F, Benvenuti M, Conde PA, Bossis G, Thomas CA, Crowder MW, Dillenberger M, Becker K, Pozzi C, Mangani S, Docquier JD, et al. 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity. European Journal of Medicinal Chemistry. 226: 113873. PMID 34626878 DOI: 10.1016/j.ejmech.2021.113873   
2021 Quratulain -, Abbas Khan M, Ahmad I, Hamad A, Ashraf M, Hussain S. Synthesis, characterization, SAR, antioxidant, anti-acetylcholinesterase and anti-butyrylcholinesterase activities of cephradine Schiff bases. Pakistan Journal of Pharmaceutical Sciences. 34: 1989-1994. PMID 34836871   
2021 Nakamura S, Nihira T, Kurata R, Nakai H, Funane K, Park EY, Miyazaki T. Structure of a bacterial α-1,2-glucosidase defines mechanisms of hydrolysis and substrate specificity in GH65 family hydrolases. The Journal of Biological Chemistry. 101366. PMID 34728215 DOI: 10.1016/j.jbc.2021.101366   
2021 Yu L, Zhou W, She Y, Ma H, Cai YS, Jiang M, Deng Z, Price NPJ, Chen W. Efficient biosynthesis of nucleoside cytokinin angustmycin A containing an unusual sugar system. Nature Communications. 12: 6633. PMID 34789759 DOI: 10.1038/s41467-021-26928-y   
2021 Kneller DW, Li H, Galanie S, Phillips G, Labbé A, Weiss KL, Zhang Q, Arnould MA, Clyde A, Ma H, Ramanathan A, Jonsson CB, Head MS, Coates L, Louis JM, et al. Structural, Electronic, and Electrostatic Determinants for Inhibitor Binding to Subsites S1 and S2 in SARS-CoV-2 Main Protease. Journal of Medicinal Chemistry. PMID 34705466 DOI: 10.1021/acs.jmedchem.1c01475   
2021 Arif T, Currie MJ, Dobson RCJ, Newson HL, Poonthiyil V, Fairbanks AJ, North RA, Rendle PM. Synthesis of N-acetylmannosamine-6-phosphate derivatives to investigate the mechanism of N-acetylmannosamine-6-phosphate 2-epimerase. Carbohydrate Research. 510: 108445. PMID 34607125 DOI: 10.1016/j.carres.2021.108445   
2021 Wei X, Matsuyama T, Sato H, Yan D, Chan PM, Miyamoto K, Uchiyama M, Matsuda Y. Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis. Journal of the American Chemical Society. PMID 34644070 DOI: 10.1021/jacs.1c08336   
2021 Maruyama S, Sawano K, Amaki S, Suzuki T, Narita S, Kimura K, Arakawa T, Yamada C, Ito Y, Dohmae N, Fujita K, Ishiwata A, Fushinobu S. Substrate complex structure, active site labeling and catalytic role of the zinc ion in cysteine glycosidase. Glycobiology. PMID 34735571 DOI: 10.1093/glycob/cwab103   
2021 Zhang TJ, Tu S, Zhang X, Wang QY, Hu SS, Zhang Y, Zhang ZH, Wang ZR, Meng FH. Amide-based xanthine oxidase inhibitors bearing an N-(1-alkyl-3-cyano-1H-indol-5-yl) moiety: Design, synthesis and structure-activity relationship investigation. Bioorganic Chemistry. 117: 105417. PMID 34673452 DOI: 10.1016/j.bioorg.2021.105417   
2021 Ghosh AK, Shahabi D, Yadav M, Kovela S, Anson BJ, Lendy EK, Bonham C, Sirohi D, Brito-Sierra CA, Hattori SI, Kuhn R, Mitsuya H, Mesecar AD. Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26. PMID 34641337 DOI: 10.3390/molecules26195782   
2021 Sharma V, Pugazhenthi G, Vasanth D. Production and characterization of a novel thermostable laccase from Bacillus licheniformis VNQ and its application in synthesis of bioactive 1,4-naphthoquinones. Journal of Bioscience and Bioengineering. PMID 34629297 DOI: 10.1016/j.jbiosc.2021.09.008   
2021 Valenzuela-Chavira I, Corona-Martinez DO, Garcia-Orozco KD, Beltran-Torres M, Sanchez-Lopez F, Arvizu-Flores AA, Sugich-Miranda R, Lopez-Zavala AA, Robles-Zepeda RE, Islas-Osuna MA, Ochoa-Leyva A, Toney MD, Serrano-Posada H, Sotelo-Mundo RR. A Novel Glutathione -Transferase Gtt2 Class (VpGSTT2) Is Found in the Genome of the AHPND/EMS Shrimp Pathogen. Toxins. 13. PMID 34564668 DOI: 10.3390/toxins13090664   
2021 Griffiths WA, Spencer KD, Thoden JB, Holden HM. Biochemical Investigation of an N-acetyltransferase from Helicobacter pullorum. Protein Science : a Publication of the Protein Society. PMID 34651380 DOI: 10.1002/pro.4207   
2021 Duong TH, Nguyen HT, Nguyen CH, Tran NM, Danova A, Tran TM, Vu-Huynh KL, Musa V, Jutakanoke R, Nguyen NH, Sichaem J. Identification of Highly Potent α-Glucosidase Inhibitors from Artocarpus integer and Molecular Docking Studies. Chemistry & Biodiversity. e2100499. PMID 34761862 DOI: 10.1002/cbdv.202100499   
2021 Sambyal K, Singh RV. Exploitation of E. coli for the production of penicillin G amidase: a tool for the synthesis of semisynthetic β-lactam antibiotics. Journal, Genetic Engineering & Biotechnology. 19: 156. PMID 34652570 DOI: 10.1186/s43141-021-00263-7   
2021 Guimarães AVF, Frota NF, Lourenzoni MR. Molecular dynamics simulations of human L-asparaginase1: Insights into structural determinants of enzymatic activity. Journal of Molecular Graphics & Modelling. 109: 108007. PMID 34461521 DOI: 10.1016/j.jmgm.2021.108007   
2021 Zhang JH, Xie HX, Li Y, Wang KM, Song Z, Zhu KK, Fang L, Zhang J, Jiang CS. Design, synthesis and biological evaluation of novel (E)-2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)hydrazine-1-carboxamide derivatives as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 128413. PMID 34634473 DOI: 10.1016/j.bmcl.2021.128413   
2021 Chang HY, Lo LH, Lan YH, Hong MX, Chan YT, Ko TP, Huang YR, Cheng TH, Liaw CC. Structural insights into the substrate selectivity of α-oxoamine synthases from marine Vibrio sp. QWI-06. Colloids and Surfaces. B, Biointerfaces. 112224. PMID 34838420 DOI: 10.1016/j.colsurfb.2021.112224   
2021 Shi Q, Chen Y, Li X, Dong H, Chen C, Zhong Z, Yang C, Liu G, Su D. The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD binding. Environmental Microbiology. PMID 34806815 DOI: 10.1111/1462-2920.15840   
2021 Khobragade TP, Sarak S, Pagar AD, Jeon H, Giri P, Yun H. Synthesis of Sitagliptin Intermediate by a Multi-Enzymatic Cascade System Using Lipase and Transaminase With Benzylamine as an Amino Donor. Frontiers in Bioengineering and Biotechnology. 9: 757062. PMID 34692666 DOI: 10.3389/fbioe.2021.757062   
2021 Pokhrel S, Bouback TA, Samad A, Nur SM, Alam R, Abdullah-Al-Mamun M, Nain Z, Imon RR, Talukder MEK, Tareq MMI, Hossen MS, Karpiński TM, Ahammad F, Qadri I, Rahman MS. Spike protein recognizer receptor ACE2 targeted identification of potential natural antiviral drug candidates against SARS-CoV-2. International Journal of Biological Macromolecules. PMID 34592225 DOI: 10.1016/j.ijbiomac.2021.09.146   
2021 Kim S, Lee J, Oh DB, Kwon O. Marine invertebrate sialyltransferase of the sea squirt Ciona savignyi sialylated core 1 O-linked glycans. International Journal of Biological Macromolecules. PMID 34813786 DOI: 10.1016/j.ijbiomac.2021.11.078   
2021 Cabezas-Pérusse Y, Daligault F, Ferrières V, Tasseau O, Tranchimand S. Modulation of the Activity and Regioselectivity of a Glycosidase: Development of a Convenient Tool for the Synthesis of Specific Disaccharides. Molecules (Basel, Switzerland). 26. PMID 34576917 DOI: 10.3390/molecules26185445   
2021 Dey D, Dhar D, Fortunato H, Obata D, Tanaka A, Tanaka R, Basu S, Ito H. Insights into the structure and function of the rate-limiting enzyme of chlorophyll degradation through analysis of a bacterial Mg-dechelatase homolog. Computational and Structural Biotechnology Journal. 19: 5333-5347. PMID 34745453 DOI: 10.1016/j.csbj.2021.09.023   
2021 Xue SW, Tian YX, Pan JC, Liu YN, Ma YL. Binding interaction of a ring-hydroxylating dioxygenase with fluoranthene in Pseudomonas aeruginosa DN1. Scientific Reports. 11: 21317. PMID 34716364 DOI: 10.1038/s41598-021-00783-9   
2021 Moore SJ, Tosi T, Bell D, Hleba YB, Polizzi KM, Freemont PS. High-yield 'one-pot' biosynthesis of raspberry ketone, a high-value fine chemical. Synthetic Biology (Oxford, England). 6: ysab021. PMID 34712844 DOI: 10.1093/synbio/ysab021   
2021 Sun P, Li Y, Li J, Zhang Y. Entrapment of horseradish peroxidase into nanometer-scale metal-organic frameworks: a new nanocarrier for signal amplification in enzyme-linked immunosorbent assay. Mikrochimica Acta. 188: 409. PMID 34739603 DOI: 10.1007/s00604-021-05065-9   
2021 Wang ZQ, Song H, Koleski EJ, Hara N, Park DS, Kumar G, Min Y, Dauenhauer PJ, Chang MCY. A dual cellular-heterogeneous catalyst strategy for the production of olefins from glucose. Nature Chemistry. PMID 34811478 DOI: 10.1038/s41557-021-00820-0   
2021 Ahn WC, An Y, Song KM, Park KH, Lee SJ, Oh BH, Park JT, Woo EJ. Dimeric architecture of maltodextrin glucosidase (MalZ) provides insights into the substrate recognition and hydrolysis mechanism. Biochemical and Biophysical Research Communications. 586: 49-54. PMID 34826700 DOI: 10.1016/j.bbrc.2021.11.070   
2021 Tegl G, Rahfeld P, Ostmann K, Hanson J, Withers SG. Discovery of β--acetylglucosaminidases from screening metagenomic libraries and their use as thioglycoligase mutants. Organic & Biomolecular Chemistry. PMID 34622263 DOI: 10.1039/d1ob01246k   
2021 Thissera B, Sayed AM, Hassan MHA, Abdelwahab SF, Amaeze N, Semler VT, Alenezi FN, Yaseen M, Alhadrami HA, Belbahri L, Rateb ME. Bioguided Isolation of Cyclopenin Analogues as Potential SARS-CoV-2 M Inhibitors from TDPEF34. Biomolecules. 11. PMID 34572579 DOI: 10.3390/biom11091366   
2021 Kshirsagar RR, Gadekar PK, Khedkar VM, Vijayakumar V. Design, Synthesis, and the Effects of ()-9-Oxooctadec-10-en-12-ynoic Acid Analogues to Promote Glucose Uptake. Acs Omega. 6: 24118-24127. PMID 34568690 DOI: 10.1021/acsomega.1c03600   
2021 Pan X, Yang J, Xie P, Zhang J, Ke F, Guo X, Liang M, Liu L, Wang Q, Gao X. Enhancement of Activity and Thermostability of Keratinase From CCTCC AB2013184 by Directed Evolution With Noncanonical Amino Acids. Frontiers in Bioengineering and Biotechnology. 9: 770907. PMID 34733836 DOI: 10.3389/fbioe.2021.770907   
2021 Dissanayake AA, Mills GL, Bonito G, Rennick B, Nair MG. Chemical Composition and Anti-Inflammatory and Antioxidant Activities of Extracts from Cultivated Morel Mushrooms, Species of Genus Morchella (Ascomycota). International Journal of Medicinal Mushrooms. 23: 73-83. PMID 34591400 DOI: 10.1615/IntJMedMushrooms.2021039297   
2021 Sangster JJ, Marshall JR, Turner NJ, Mangas-Sanchez J. New trends and future opportunities in the enzymatic formation of C-C, C-N, and C-O bonds. Chembiochem : a European Journal of Chemical Biology. PMID 34726813 DOI: 10.1002/cbic.202100464   
2021 Mishra A, Khan WH, Rathore AS. Synergistic Effects of Natural Compounds Toward Inhibition of SARS-CoV-2 3CL Protease. Journal of Chemical Information and Modeling. PMID 34694807 DOI: 10.1021/acs.jcim.1c00994   
2021 Sun Z, Palzkill T. Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1. Mbio. e0277621. PMID 34781730 DOI: 10.1128/mBio.02776-21   
2021 Ko JA, Kim SY, Ahn HS, Go JG, Ryu YB, Lee WS, Wee YJ, Park JS, Kim D, Kim YM. Characterization of a lactic acid bacterium-derived β-glucosidase for the production of rubusoside from stevioside. Enzyme and Microbial Technology. 153: 109939. PMID 34798448 DOI: 10.1016/j.enzmictec.2021.109939   
2021 Zhang JS, Hu Y, Song KS, Wu F, Zhu K, Xu DF, Zhang H. Diterpenoid glucosides with cystathionine γ-lyase inhibitory activity from Tinospora sinensis. Bioorganic Chemistry. 116: 105400. PMID 34627118 DOI: 10.1016/j.bioorg.2021.105400   
2021 Azimi F, Azizian H, Najafi M, Khodarahmi G, Saghaei L, Hassanzadeh M, Ghasemi JB, Faramarzi MA, Larijani B, Hassanzadeh F, Mahdavi M. Design, synthesis, biological evaluation, and molecular modeling studies of pyrazole-benzofuran hybrids as new α-glucosidase inhibitor. Scientific Reports. 11: 20776. PMID 34675367 DOI: 10.1038/s41598-021-99899-1   
2021 Low YS, Garcia MD, Lonhienne T, Fraser JA, Schenk G, Guddat LW. Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads. Scientific Reports. 11: 21055. PMID 34702838 DOI: 10.1038/s41598-021-00349-9   
2021 Kashima T, Okumura K, Ishiwata A, Kaieda M, Terada T, Arakawa T, Yamada C, Shimizu K, Tanaka K, Kitaoka M, Ito Y, Fujita K, Fushinobu S. Identification of a difructose dianhydride I synthase/hydrolase from oral bacterium establishes a novel glycoside hydrolase family. The Journal of Biological Chemistry. 101324. PMID 34688653 DOI: 10.1016/j.jbc.2021.101324   
2021 Zhang H, Zhang X, Huang Y, Yuan J, Wei X, Ju J. Discovery, Structure Correction, and Biosynthesis of Actinopyrones, Cytotoxic Polyketides from the Deep-Sea Hydrothermal-Vent-Derived sp. SCSIO ZS0520. Journal of Natural Products. PMID 34852194 DOI: 10.1021/acs.jnatprod.1c00901   
2021 Wang Y, Wang J, Wang S, Cao Z, Gu D, Wang Y, Tian J, Yang Y. An efficient method based on an inhibitor-enzyme complex to screen an active compound against lipase from . Food & Function. PMID 34617090 DOI: 10.1039/d1fo01542g   
2021 Linz AM, Ma Y, Perez JM, Myers KS, Kontur WS, Noguera DR, Donohue TJ. Aromatic dimer dehydrogenases from reduce monoaromatic diketones. Applied and Environmental Microbiology. AEM0174221. PMID 34613756 DOI: 10.1128/AEM.01742-21   
2021 Wang Y, Xiang Q, Zhou Q, Xu J, Pei D. Mini Review: Advances in 2-Haloacid Dehalogenases. Frontiers in Microbiology. 12: 758886. PMID 34721367 DOI: 10.3389/fmicb.2021.758886   
2021 Xiao Z, Hou X, Zhang T, Yuan Y, Xiao J, Song W, Yue T. Starch-digesting product analysis based on the hydrophilic interaction liquid chromatography coupled mass spectrometry method to evaluate the inhibition of flavonoids on pancreatic α-amylase. Food Chemistry. 372: 131175. PMID 34653779 DOI: 10.1016/j.foodchem.2021.131175   
2021 Chirgadze YN, Battaile KP, Likhachev IV, Balabaev NK, Gordon RD, Romanov V, Lin A, Karisch R, Lam R, Ruzanov M, Brazhnikov EV, Pai EF, Neel BG, Chirgadze NY. Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058. Journal of Biomolecular Structure & Dynamics. 1-10. PMID 34705594 DOI: 10.1080/07391102.2021.1994879