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Andrew S. Murkin, Ph.D. - Publications

Affiliations: 
1998-2004 Chemistry University of British Columbia, Vancouver, Vancouver, BC, Canada 
 2004-2009 Biochemistry Albert Einstein College of Medicine, New York, New York, United States 
 2009- Chemistry State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Studies on novel enzyme mechanisms; epimerases and racemases; sugar nucleotide-modifying enzymes; isotope effects; inhibitor design; site-directed mutagenesis
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Veeramachineni VM, Ubayawardhana ST, Murkin AS. Kinetic characterization of methylthio-d-ribose-1-phosphate isomerase. Methods in Enzymology. 685: 279-318. PMID 37245905 DOI: 10.1016/bs.mie.2023.03.015  0.354
2022 Veeramachineni VM, Ubayawardhana ST, Murkin AS. Covalent Adduct Formation in Methylthio-d-ribose-1-phosphate Isomerase: Reaction Intermediate or Artifact? Biochemistry. PMID 35580612 DOI: 10.1021/acs.biochem.2c00142  0.374
2020 Fernandez PL, Murkin AS. Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions. Molecules (Basel, Switzerland). 25. PMID 32326332 DOI: 10.3390/molecules25081933  0.705
2018 Ray S, Kreitler DF, Gulick AM, Murkin AS. The Nitro Group as a Masked Electrophile in Covalent Enzyme Inhibition. Acs Chemical Biology. PMID 29782144 DOI: 10.1021/Acschembio.8B00225  0.355
2017 Pham TV, Murkin AS, Moynihan MM, Harris L, Tyler PC, Shetty N, Sacchettini JC, Huang HL, Meek TD. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28679637 DOI: 10.1073/Pnas.1706134114  0.309
2015 Kholodar SA, Allen CL, Gulick AM, Murkin AS. The role of phosphate in a multistep enzymatic reaction: reactions of the substrate and intermediate in pieces. Journal of the American Chemical Society. 137: 2748-56. PMID 25642788 DOI: 10.1021/Ja512911F  0.748
2014 Murkin AS, Manning KA, Kholodar SA. Mechanism and inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorganic Chemistry. 57: 171-85. PMID 24998420 DOI: 10.1016/j.bioorg.2014.06.001  0.713
2014 Kholodar SA, Tombline G, Liu J, Tan Z, Allen CL, Gulick AM, Murkin AS. Alteration of the flexible loop in 1-deoxy-D-xylulose-5-phosphate reductoisomerase boosts enthalpy-driven inhibition by fosmidomycin. Biochemistry. 53: 3423-31. PMID 24825256 DOI: 10.1021/Bi5004074  0.728
2014 Murkin AS, Moynihan MM. Transition-state-guided drug design for treatment of parasitic neglected tropical diseases. Current Medicinal Chemistry. 21: 1781-93. PMID 24083604 DOI: 10.2174/09298673113206660285  0.335
2013 Kholodar SA, Murkin AS. DXP reductoisomerase: reaction of the substrate in pieces reveals a catalytic role for the nonreacting phosphodianion group. Biochemistry. 52: 2302-8. PMID 23473304 DOI: 10.1021/bi400092n  0.745
2012 Liu J, Murkin AS. Pre-steady-state kinetic analysis of 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Mycobacterium tuberculosis reveals partially rate-limiting product release by parallel pathways. Biochemistry. 51: 5307-19. PMID 22690952 DOI: 10.1021/bi300513r  0.39
2011 Cassera MB, Hazleton KZ, Merino EF, Obaldia N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL. Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. Plos One. 6: e26916. PMID 22096507 DOI: 10.1371/journal.pone.0026916  0.449
2011 Silva RG, Murkin AS, Schramm VL. Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proceedings of the National Academy of Sciences of the United States of America. 108: 18661-5. PMID 22065757 DOI: 10.1073/Pnas.1114900108  0.542
2011 Silva RG, Hirschi JS, Ghanem M, Murkin AS, Schramm VL. Arsenate and phosphate as nucleophiles at the transition states of human purine nucleoside phosphorylase. Biochemistry. 50: 2701-9. PMID 21348499 DOI: 10.1021/Bi200279S  0.547
2009 Ghanem M, Murkin AS, Schramm VL. Ribocation transition state capture and rebound in human purine nucleoside phosphorylase. Chemistry & Biology. 16: 971-9. PMID 19778725 DOI: 10.1016/J.Chembiol.2009.07.012  0.58
2009 Clinch K, Evans GB, Fröhlich RF, Furneaux RH, Kelly PM, Legentil L, Murkin AS, Li L, Schramm VL, Tyler PC, Woolhouse AD. Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 52: 1126-43. PMID 19170524 DOI: 10.1021/Jm801421Q  0.482
2008 Mason JM, Murkin AS, Li L, Schramm VL, Gainsford GJ, Skelton BW. A beta-fluoroamine inhibitor of purine nucleoside phosphorylase. Journal of Medicinal Chemistry. 51: 5880-4. PMID 18800772 DOI: 10.1021/Jm800792B  0.433
2008 Murkin AS, Clinch K, Mason JM, Tyler PC, Schramm VL. Immucillins in custom catalytic-site cavities. Bioorganic & Medicinal Chemistry Letters. 18: 5900-3. PMID 18778937 DOI: 10.1016/J.Bmcl.2008.08.047  0.563
2008 Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC. Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. Journal of Medicinal Chemistry. 51: 948-56. PMID 18251493 DOI: 10.1021/Jm701265N  0.581
2008 Murkin AS, Tyler PC, Schramm VL. Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects. Journal of the American Chemical Society. 130: 2166-7. PMID 18229929 DOI: 10.1021/Ja7104398  0.526
2008 Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL. L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase. Journal of the American Chemical Society. 130: 842-4. PMID 18154341 DOI: 10.1021/Ja710733G  0.529
2007 Murkin AS, Birck MR, Rinaldo-Matthis A, Shi W, Taylor EA, Almo SC, Schramm VL. Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry. 46: 5038-49. PMID 17407325 DOI: 10.1021/Bi700147B  0.705
2006 Deng H, Murkin AS, Schramm VL. Phosphate activation in the ground state of purine nucleoside phosphorylase. Journal of the American Chemical Society. 128: 7765-71. PMID 16771490 DOI: 10.1021/Ja0570281  0.543
2006 Taylor Ringia EA, Tyler PC, Evans GB, Furneaux RH, Murkin AS, Schramm VL. Transition state analogue discrimination by related purine nucleoside phosphorylases. Journal of the American Chemical Society. 128: 7126-7. PMID 16734442 DOI: 10.1021/ja061403n  0.548
2004 Murkin AS, Chou WK, Wakarchuk WW, Tanner ME. Identification and mechanism of a bacterial hydrolyzing UDP-N-acetylglucosamine 2-epimerase Biochemistry. 43: 14290-14298. PMID 15518580 DOI: 10.1021/Bi048606D  0.662
2004 Vann WF, Daines DA, Murkin AS, Tanner ME, Chaffin DO, Rubens CE, Vionnet J, Silver RP. The NeuC Protein of Escherichia coli K1 is a UDP N-Acetylglucosamine 2-Epimerase Journal of Bacteriology. 186: 706-712. PMID 14729696 DOI: 10.1128/Jb.186.3.706-712.2004  0.576
2002 Murkin AS, Tanner ME. Dehydroalanine-based inhibition of a peptide epimerase from spider venom. The Journal of Organic Chemistry. 67: 8389-94. PMID 12444615 DOI: 10.1021/Jo0204653  0.587
2002 Murkin AS, Tanner ME. Dehydroalanine-based inhibition of a peptide epimerase from spider venom Journal of Organic Chemistry. 67: 8389-8394. DOI: 10.1021/jo0204653  0.495
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