Peter Mundel - Publications

Affiliations: 
Developmental and Stem Cell Biology (DSCB) Mount Sinai School of Medicine, New York, NY 
Area:
Cell Biology, Biochemistry, Molecular Biology

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Inoue K, Tian X, Velazquez H, Soda K, Wang Z, Pedigo CE, Wang Y, Cross E, Groener M, Shin JW, Li W, Hassan H, Yamamoto K, Mundel P, Ishibe S. Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury. Journal of the American Society of Nephrology : Jasn. PMID 31511362 DOI: 10.1681/Asn.2019010053  0.315
2018 Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. Jci Insight. 3. PMID 29467330 DOI: 10.1172/Jci.Insight.95091  0.338
2017 Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, et al. GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death. Cell Chemical Biology. PMID 29249695 DOI: 10.1016/J.Chembiol.2017.11.006  0.347
2017 Shirata N, Ihara KI, Yamamoto-Nonaka K, Seki T, Makino SI, Oliva Trejo JA, Miyake T, Yamada H, Campbell KN, Nakagawa T, Mori K, Yanagita M, Mundel P, Nishimori K, Asanuma K. Glomerulosclerosis Induced by Deficiency of Membrane-Associated Guanylate Kinase Inverted 2 in Kidney Podocytes. Journal of the American Society of Nephrology : Jasn. PMID 28539383 DOI: 10.1681/Asn.2016121356  0.348
2016 Buvall L, Wallentin H, Sieber J, Andreeva S, Choi HY, Mundel P, Greka A. Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes. Journal of the American Society of Nephrology : Jasn. PMID 27628902 DOI: 10.1681/Asn.2016040414  0.334
2016 Verbich D, Becker D, Vlachos A, Mundel P, Deller T, McKinney RA. Rewiring neuronal microcircuits of the brain via spine head protrusions-a role for synaptopodin and intracellular calcium stores. Acta Neuropathologica Communications. 4: 38. PMID 27102112 DOI: 10.1186/S40478-016-0311-X  0.301
2015 Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, et al. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science (New York, N.Y.). 349. PMID 26228159 DOI: 10.1126/Science.1261669  0.326
2015 Weins A, Wong JS, Basgen JM, Gupta R, Daehn I, Casagrande L, Lessman D, Schwartzman M, Meliambro K, Patrakka J, Shaw A, Tryggvason K, He JC, Nicholas SB, Mundel P, et al. Dendrin Ablation Prolongs Life Span by Delaying Kidney Failure. The American Journal of Pathology. PMID 26073036 DOI: 10.1016/J.Ajpath.2015.04.011  0.359
2014 Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. MAGI-2 scaffold protein is critical for kidney barrier function. Proceedings of the National Academy of Sciences of the United States of America. 111: 14876-81. PMID 25271328 DOI: 10.1073/Pnas.1417297111  0.392
2014 Hakroush S, Cebulla A, Schaldecker T, Behr D, Mundel P, Weins A. Extensive podocyte loss triggers a rapid parietal epithelial cell response. Journal of the American Society of Nephrology : Jasn. 25: 927-38. PMID 24335975 DOI: 10.1681/Asn.2013070687  0.39
2013 Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nature Communications. 4: 2863. PMID 24287595 DOI: 10.1038/Ncomms3863  0.689
2013 Gurkan S, Cabinian A, Lopez V, Bhaumik M, Chang JM, Rabson AB, Mundel P. Inhibition of type I interferon signalling prevents TLR ligand-mediated proteinuria. The Journal of Pathology. 231: 248-56. PMID 24151637 DOI: 10.1002/Path.4235  0.354
2013 Zhang XL, Pöschel B, Faul C, Upreti C, Stanton PK, Mundel P. Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12510-8. PMID 23884954 DOI: 10.1523/Jneurosci.2983-12.2013  0.32
2013 Sieber J, Weins A, Kampe K, Gruber S, Lindenmeyer MT, Cohen CD, Orellana JM, Mundel P, Jehle AW. Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. The American Journal of Pathology. 183: 735-44. PMID 23867797 DOI: 10.1016/J.Ajpath.2013.05.023  0.321
2013 Campbell KN, Wong JS, Gupta R, Asanuma K, Sudol M, He JC, Mundel P. Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling. The Journal of Biological Chemistry. 288: 17057-62. PMID 23667252 DOI: 10.1074/Jbc.C113.457390  0.397
2012 Greka A, Mundel P. Calcium regulates podocyte actin dynamics. Seminars in Nephrology. 32: 319-26. PMID 22958486 DOI: 10.1016/J.Semnephrol.2012.06.003  0.404
2012 Jeon J, Leibiger I, Moede T, Walter B, Faul C, Maiguel D, Villarreal R, Guzman J, Berggren PO, Mundel P, Ricordi C, Merscher-Gomez S, Fornoni A. Dynamin-mediated Nephrin phosphorylation regulates glucose-stimulated insulin release in pancreatic beta cells. The Journal of Biological Chemistry. 287: 28932-42. PMID 22718751 DOI: 10.1074/Jbc.M112.389452  0.323
2012 Wong JS, Iorns E, Rheault MN, Ward TM, Rashmi P, Weber U, Lippman ME, Faul C, Mlodzik M, Mundel P. Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin α in RhoA stabilization. The Embo Journal. 31: 1028-40. PMID 22157816 DOI: 10.1038/Emboj.2011.464  0.704
2012 Greka A, Mundel P. Cell biology and pathology of podocytes. Annual Review of Physiology. 74: 299-323. PMID 22054238 DOI: 10.1146/Annurev-Physiol-020911-153238  0.304
2011 Greka A, Mundel P. Balancing calcium signals through TRPC5 and TRPC6 in podocytes. Journal of the American Society of Nephrology : Jasn. 22: 1969-80. PMID 21980113 DOI: 10.1681/Asn.2011040370  0.315
2011 Oh J, Beckmann J, Bloch J, Hettgen V, Mueller J, Li L, Hoemme M, Gross ML, Penzel R, Mundel P, Schaefer F, Schmitt CP. Stimulation of the calcium-sensing receptor stabilizes the podocyte cytoskeleton, improves cell survival, and reduces toxin-induced glomerulosclerosis. Kidney International. 80: 483-92. PMID 21508926 DOI: 10.1038/Ki.2011.105  0.333
2011 Campbell KN, Raij L, Mundel P. Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes. Current Diabetes Reviews. 7: 3-7. PMID 21067505 DOI: 10.2174/157339911794273973  0.339
2010 Sieber J, Lindenmeyer MT, Kampe K, Campbell KN, Cohen CD, Hopfer H, Mundel P, Jehle AW. Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids. American Journal of Physiology. Renal Physiology. 299: F821-9. PMID 20668104 DOI: 10.1152/Ajprenal.00196.2010  0.316
2010 Fornoni A, Jeon J, Varona Santos J, Cobianchi L, Jauregui A, Inverardi L, Mandic SA, Bark C, Johnson K, McNamara G, Pileggi A, Molano RD, Reiser J, Tryggvason K, Kerjaschki D, ... ... Mundel P, et al. Nephrin is expressed on the surface of insulin vesicles and facilitates glucose-stimulated insulin release. Diabetes. 59: 190-9. PMID 19833886 DOI: 10.2337/Db09-0655  0.313
2009 Adair BD, Altintas M, Möller CC, Flesche J, Wei C, Faul C, Campbell K, Gu C, Sever S, Shaw A, Mundel P, Reiser J. CD2AP Structure And Progression Of Renal Disease Biophysical Journal. 96: 132a-133a. DOI: 10.1016/J.Bpj.2008.12.601  0.34
2008 Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, Delfgaauw J, Chang JM, Choi HY, Campbell KN, Kim K, Reiser J, Mundel P. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nature Medicine. 14: 931-8. PMID 18724379 DOI: 10.1038/Nm.1857  0.363
2008 Saleem MA, Zavadil J, Bailly M, McGee K, Witherden IR, Pavenstadt H, Hsu H, Sanday J, Satchell SC, Lennon R, Ni L, Bottinger EP, Mundel P, Mathieson PW. The molecular and functional phenotype of glomerular podocytes reveals key features of contractile smooth muscle cells. American Journal of Physiology. Renal Physiology. 295: F959-70. PMID 18684887 DOI: 10.1152/Ajprenal.00559.2007  0.333
2008 Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, ... ... Mundel P, et al. Modification of kidney barrier function by the urokinase receptor. Nature Medicine. 14: 55-63. PMID 18084301 DOI: 10.1038/Nm1696  0.31
2007 Reiser J, Mundel P. Dual effects of RAS blockade on blood pressure and podocyte function. Current Hypertension Reports. 9: 403-8. PMID 18177588 DOI: 10.1007/S11906-007-0074-7  0.314
2007 Yanagida-Asanuma E, Asanuma K, Kim K, Donnelly M, Young Choi H, Hyung Chang J, Suetsugu S, Tomino Y, Takenawa T, Faul C, Mundel P. Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes. The American Journal of Pathology. 171: 415-27. PMID 17569780 DOI: 10.2353/Ajpath.2007.070075  0.308
2006 Huber TB, Kwoh C, Wu H, Asanuma K, Gödel M, Hartleben B, Blumer KJ, Miner JH, Mundel P, Shaw AS. Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin. The Journal of Clinical Investigation. 116: 1337-45. PMID 16628251 DOI: 10.1172/Jci27400  0.326
2005 Morigi M, Buelli S, Angioletti S, Zanchi C, Longaretti L, Zoja C, Galbusera M, Gastoldi S, Mundel P, Remuzzi G, Benigni A. In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies. The American Journal of Pathology. 166: 1309-20. PMID 15855633 DOI: 10.1016/S0002-9440(10)62350-4  0.347
2005 Hino M, Nagase M, Kaname S, Shibata S, Nagase T, Oba S, Funaki M, Kobayashi N, Kawachi H, Mundel P, Fujita T. Expression and regulation of adrenomedullin in renal glomerular podocytes. Biochemical and Biophysical Research Communications. 330: 178-85. PMID 15781248 DOI: 10.1016/J.Bbrc.2005.02.142  0.37
2004 Reiser J, Mundel P. Danger signaling by glomerular podocytes defines a novel function of inducible B7-1 in the pathogenesis of nephrotic syndrome. Journal of the American Society of Nephrology : Jasn. 15: 2246-8. PMID 15339973 DOI: 10.1097/01.Asn.0000136312.46464.33  0.382
2004 Schiffer M, Mundel P, Shaw AS, Böttinger EP. A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis. The Journal of Biological Chemistry. 279: 37004-12. PMID 15213232 DOI: 10.1074/Jbc.M403534200  0.304
2004 Reiser J, Oh J, Shirato I, Asanuma K, Hug A, Mundel TM, Honey K, Ishidoh K, Kominami E, Kreidberg JA, Tomino Y, Mundel P. Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and α3 integrin Journal of Biological Chemistry. 279: 34827-34832. PMID 15197181 DOI: 10.1074/Jbc.M401973200  0.313
2004 Petermann A, Hiromura K, Pippin J, Blonski M, Couser WG, Kopp J, Mundel P, Shankland SJ. Differential expression of d-type cyclins in podocytes in vitro and in vivo. The American Journal of Pathology. 164: 1417-24. PMID 15039229 DOI: 10.1016/S0002-9440(10)63228-2  0.321
2004 Yamazaki H, Saito A, Ooi H, Kobayashi N, Mundel P, Gejyo F. Differentiation-induced cultured podocytes express endocytically active megalin, a heymann nephritis antigen. Nephron. Experimental Nephrology. 96: e52-8. PMID 14988592 DOI: 10.1159/000076404  0.338
2004 Oh J, Reiser J, Mundel P. Dynamic (re)organization of the podocyte actin cytoskeleton in the nephrotic syndrome. Pediatric Nephrology (Berlin, Germany). 19: 130-7. PMID 14673634 DOI: 10.1007/S00467-003-1367-Y  0.397
2003 Asanuma K, Mundel P. The role of podocytes in glomerular pathobiology. Clinical and Experimental Nephrology. 7: 255-9. PMID 14712353 DOI: 10.1007/S10157-003-0259-6  0.372
2003 Han GD, Koike H, Nakatsue T, Suzuki K, Yoneyama H, Narumi S, Kobayashi N, Mundel P, Shimizu F, Kawachi H. IFN-inducible protein-10 has a differential role in podocyte during Thy 1.1 glomerulonephritis. Journal of the American Society of Nephrology : Jasn. 14: 3111-26. PMID 14638910 DOI: 10.1097/01.Asn.0000097371.64671.65  0.363
2003 Sanchez-Carbayo M, Schwarz K, Charytonowicz E, Cordon-Cardo C, Mundel P. Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome. Oncogene. 22: 5298-305. PMID 12917631 DOI: 10.1038/Sj.Onc.1206616  0.308
2003 Zhang X, Li Y, Dai C, Yang J, Mundel P, Liu Y. Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney. American Journal of Physiology. Renal Physiology. 284: F82-94. PMID 12473536 DOI: 10.1152/Ajprenal.00200.2002  0.338
2002 Mundel P, Shankland SJ. Podocyte biology and response to injury. Journal of the American Society of Nephrology : Jasn. 13: 3005-15. PMID 12444221 DOI: 10.1097/01.Asn.0000039661.06947.Fd  0.329
2002 Schiffer M, Schiffer LE, Gupta A, Shaw AS, Roberts IS, Mundel P, Böttinger EP. Inhibitory smads and tgf-Beta signaling in glomerular cells. Journal of the American Society of Nephrology : Jasn. 13: 2657-66. PMID 12397035 DOI: 10.1097/01.Asn.0000033276.06451.50  0.323
2002 Sörensson J, Fierlbeck W, Heider T, Schwarz K, Park DS, Mundel P, Lisanti M, Ballermann BJ. Glomerular endothelial fenestrae in vivo are not formed from caveolae. Journal of the American Society of Nephrology : Jasn. 13: 2639-47. PMID 12397033 DOI: 10.1097/01.Asn.0000033277.32822.23  0.35
2002 Saleem MA, Ni L, Witherden I, Tryggvason K, Ruotsalainen V, Mundel P, Mathieson PW. Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation. The American Journal of Pathology. 161: 1459-66. PMID 12368218 DOI: 10.1016/S0002-9440(10)64421-5  0.378
2002 Deller T, Haas CA, Deissenrieder K, Del Turco D, Coulin C, Gebhardt C, Drakew A, Schwarz K, Mundel P, Frotscher M. Laminar distribution of synaptopodin in normal and reeler mouse brain depends on the position of spine-bearing neurons. The Journal of Comparative Neurology. 453: 33-44. PMID 12357430 DOI: 10.1002/Cne.10362  0.303
2002 Cooper ME, Mundel P, Boner G. Role of nephrin in renal disease including diabetic nephropathy. Seminars in Nephrology. 22: 393-8. PMID 12224046 DOI: 10.1053/Snep.2002.34724  0.376
2002 Natoli TA, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, Mundel P, Kalluri R, Miner JH, Quaggin SE, Kreidberg JA. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. Journal of the American Society of Nephrology : Jasn. 13: 2058-67. PMID 12138137 DOI: 10.1097/01.Asn.0000022420.48110.4B  0.385
2002 Reiser J, von Gersdorff G, Simons M, Schwarz K, Faul C, Giardino L, Heider T, Loos M, Mundel P. Novel concepts in understanding and management of glomerular proteinuria. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 17: 951-5. PMID 12032178 DOI: 10.1093/Ndt/17.6.951  0.375
2001 Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS. CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. The American Journal of Pathology. 159: 2303-8. PMID 11733379 DOI: 10.1016/S0002-9440(10)63080-5  0.365
2001 Simons M, Schwarz K, Kriz W, Miettinen A, Reiser J, Mundel P, Holthöfer H. Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm American Journal of Pathology. 159: 1069-1077. PMID 11549599 DOI: 10.1016/S0002-9440(10)61782-8  0.35
2001 Kobayashi N, Reiser J, Schwarz K, Sakai T, Kriz W, Mundel P. Process formation of podocytes: Morphogenetic activity of microtubules and regulation by protein serine/threonine phosphatase PP2A Histochemistry and Cell Biology. 115: 255-266. PMID 11326753 DOI: 10.1007/S004180000242  0.353
2001 Roth SU, Sommer C, Mundel P, Kiessling M. Expression of synaptopodin, an actin-associated protein, in the rat hippocampus after limbic epilepsy Brain Pathology. 11: 169-181. PMID 11303792 DOI: 10.1111/J.1750-3639.2001.Tb00389.X  0.313
2000 Barisoni L, Bruggeman LA, Mundel P, D'Agati VD, Klotman PE. HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy Kidney International. 58: 173-181. PMID 10886562 DOI: 10.1046/J.1523-1755.2000.00152.X  0.353
2000 Barisoni L, Mokrzycki M, Sablay L, Nagata M, Yamase H, Mundel P. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies Kidney International. 58: 137-143. PMID 10886558 DOI: 10.1046/J.1523-1755.2000.00149.X  0.336
2000 Somlo S, Mundel P. Getting a foothold in nephrotic syndrome Nature Genetics. 24: 333-335. PMID 10742089 DOI: 10.1038/74139  0.312
2000 Deller T, Merten T, Roth SU, Mundel P, Frotscher M. Actin-associated protein synaptopodin in the rat hippocampal formation: localization in the spine neck and close association with the spine apparatus of principal neurons. The Journal of Comparative Neurology. 418: 164-81. PMID 10701442 DOI: 10.1002/(Sici)1096-9861(20000306)418:2<164::Aid-Cne4>3.0.Co;2-0  0.346
1999 Mundel P, Shankland SJ. Glomerular podocytes and adhesive interaction with glomerular basement membrane Experimental Nephrology. 7: 160-166. PMID 10213869 DOI: 10.1159/000020596  0.316
1999 Mundel P, Shankland SJ, Horton MA, Hart S, Pröls F, Hartner A, Schöcklmann HO, Sterzel RB, Norman JT, Fine LG, Rosenkranz AR, Mayadas TN, Wilson PD, Burrow CR, Fogo AB, et al. Adhesion Molecules in Renal Disease Nephron Experimental Nephrology. 7: 75-77. DOI: 10.1159/000020588  0.312
1998 Kretzler M, Schroppel B, Merkle M, Huber S, Mundel P, Horster M, Schlondorff D. Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes Kidney International, Supplement. 54. PMID 9736276 DOI: 10.1046/J.1523-1755.1998.06733.X  0.34
1998 Smoyer WE, Mundel P. Regulation of podocyte structure during the development of nephrotic syndrome Journal of Molecular Medicine. 76: 172-183. PMID 9535550 DOI: 10.1007/S001090050206  0.332
1997 Mundel P, Reiser J, Borja AZM, Pavenstädt H, Davidson GR, Kriz W, Zeller R. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines Experimental Cell Research. 236: 248-258. PMID 9344605 DOI: 10.1006/Excr.1997.3739  0.368
1996 Smoyer WE, Gupta A, Mundel P, Ballew JD, Welsh MJ. Altered expression of glomerular heat shock protein 27 in experimental nephrotic syndrome. The Journal of Clinical Investigation. 97: 2697-704. PMID 8675679 DOI: 10.1172/Jci118723  0.378
1995 Mundel P, Kriz W. Structure and function of podocytes: an update Anatomy and Embryology. 192: 385-397. PMID 8546330 DOI: 10.1007/Bf00240371  0.324
1995 Bachmann S, Bosse HM, Mundel P. Topography of nitric oxide synthesis by localizing constitutive NO synthases in mammalian kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 268. PMID 7539586 DOI: 10.1152/Ajprenal.1995.268.5.F885  0.35
1994 Bachmann S, Mundel P. Nitric oxide in the kidney: Synthesis, localization, and function American Journal of Kidney Diseases. 24: 112-129. PMID 7517625 DOI: 10.1016/S0272-6386(12)80170-3  0.343
1992 Mundel P, Bachmann S, Bader M, Fischer A, Kummer W, Mayer B, Kriz W. Expression of nitric oxide synthase in kidney macula densa cells Kidney International. 42: 1017-1019. PMID 1280698 DOI: 10.1038/Ki.1992.382  0.332
1991 Mundel P, Gilbert P, Kriz W. Podocytes in glomerulus of rat kidney express a characteristic 44 KD protein Journal of Histochemistry and Cytochemistry. 39: 1047-1056. PMID 1856454 DOI: 10.1177/39.8.1856454  0.376
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