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Erik J. Sontheimer, Ph.D. - Publications

Affiliations: 
1999-2014 Molecular Biosciences Northwestern University, Evanston, IL 
 2014- RNA Therapeutics Institute University Of Massachusetts Med Sch Worcester 
Area:
RNA biology, CRISPR, genome editing
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51/114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kraus C, Sontheimer EJ. Viruses use RNA decoys to thwart CRISPR defences. Nature. 623: 490-491. PMID 37853195 DOI: 10.1038/d41586-023-03133-z  0.376
2022 Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ. A split prime editor with untethered reverse transcriptase and circular RNA template. Nature Biotechnology. PMID 35379962 DOI: 10.1038/s41587-022-01255-9  0.367
2020 Barrangou R, Sontheimer EJ. Shutting down RNA-targeting CRISPR. Science (New York, N.Y.). 369: 31-32. PMID 32631881 DOI: 10.1126/science.abc8243  0.5
2019 Gao XD, Rodríguez TC, Sontheimer EJ. Adapting dCas9-APEX2 for subnuclear proteomic profiling. Methods in Enzymology. 616: 365-383. PMID 30691651 DOI: 10.1016/bs.mie.2018.10.030  0.328
2018 Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nature Communications. 9: 2641. PMID 29980686 DOI: 10.1038/S41467-018-05073-Z  0.507
2016 Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science (New York, N.Y.). 351: 920-1. PMID 26917756 DOI: 10.1126/Science.Aaf2851  0.654
2015 Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ. DNase H Activity of Neisseria meningitidis Cas9. Molecular Cell. 60: 242-55. PMID 26474066 DOI: 10.1016/j.molcel.2015.09.020  0.502
2015 Wakefield N, Rajan R, Sontheimer EJ. Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. Febs Letters. 589: 3197-204. PMID 26364721 DOI: 10.1016/j.febslet.2015.09.005  0.711
2015 Sontheimer EJ, Barrangou R. The Bacterial Origins of the CRISPR Genome-Editing Revolution. Human Gene Therapy. 26: 413-24. PMID 26078042 DOI: 10.1089/hum.2015.091  0.337
2013 Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proceedings of the National Academy of Sciences of the United States of America. 110: 15644-9. PMID 23940360 DOI: 10.1073/Pnas.1313587110  0.514
2013 Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ. Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis. Molecular Cell. 50: 488-503. PMID 23706818 DOI: 10.1016/J.Molcel.2013.05.001  0.537
2013 Kim Guisbert KS, Sontheimer EJ. Quit stalling or you'll be silenced. Cell. 152: 938-9. PMID 23452843 DOI: 10.1016/j.cell.2013.02.025  0.489
2012 Sontheimer EJ. Small RNAs of opposite sign… but same absolute value. Cell. 151: 1157-8. PMID 23217700 DOI: 10.1016/j.cell.2012.11.032  0.44
2011 Gerbasi VR, Preall JB, Golden DE, Powell DW, Cummins TD, Sontheimer EJ. Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 3204-9. PMID 21300896 DOI: 10.1073/Pnas.1009781108  0.526
2010 Sontheimer EJ, Marraffini LA. Microbiology: slicer for DNA. Nature. 468: 45-6. PMID 21048757 DOI: 10.1038/468045A  0.663
2010 Gerbasi VR, Golden DE, Hurtado SB, Sontheimer EJ. Proteomics identification of Drosophila small interfering RNA-associated factors. Molecular & Cellular Proteomics : McP. 9: 1866-72. PMID 20472918 DOI: 10.1074/Mcp.M900614-Mcp200  0.535
2010 Marraffini LA, Sontheimer EJ. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nature Reviews. Genetics. 11: 181-90. PMID 20125085 DOI: 10.1038/Nrg2749  0.717
2010 Marraffini LA, Sontheimer EJ. Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature. 463: 568-71. PMID 20072129 DOI: 10.1038/Nature08703  0.649
2009 Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim do H, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW. Silencing by small RNAs is linked to endosomal trafficking. Nature Cell Biology. 11: 1150-6. PMID 19684574 DOI: 10.1038/Ncb1930  0.823
2009 Marraffini LA, Sontheimer EJ. Invasive DNA, chopped and in the CRISPR. Structure (London, England : 1993). 17: 786-8. PMID 19523896 DOI: 10.1016/J.Str.2009.05.002  0.606
2009 Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 136: 642-55. PMID 19239886 DOI: 10.1016/j.cell.2009.01.035  0.368
2008 Marraffini LA, Sontheimer EJ. CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science (New York, N.Y.). 322: 1843-5. PMID 19095942 DOI: 10.1126/Science.1165771  0.627
2008 Bellare P, Small EC, Huang X, Wohlschlegel JA, Staley JP, Sontheimer EJ. A role for ubiquitin in the spliceosome assembly pathway. Nature Structural & Molecular Biology. 15: 444-51. PMID 18425143 DOI: 10.1038/Nsmb.1401  0.778
2007 Bellare P, Sontheimer EJ. A fork in the road for microRNAs. Nature Structural & Molecular Biology. 14: 684-6. PMID 17676029 DOI: 10.1038/nsmb0807-684  0.743
2006 Preall JB, He Z, Gorra JM, Sontheimer EJ. Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila. Current Biology : Cb. 16: 530-5. PMID 16527750 DOI: 10.1016/j.cub.2006.01.061  0.813
2006 Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. Rna (New York, N.Y.). 12: 292-302. PMID 16428608 DOI: 10.1261/Rna.2152306  0.775
2005 Preall JB, Sontheimer EJ. RNAi: RISC gets loaded. Cell. 123: 543-5. PMID 16286001 DOI: 10.1016/j.cell.2005.11.006  0.352
2005 Pham JW, Sontheimer EJ. Molecular requirements for RNA-induced silencing complex assembly in the Drosophila RNA interference pathway. The Journal of Biological Chemistry. 280: 39278-83. PMID 16179342 DOI: 10.1074/jbc.M509202200  0.721
2005 Pellino JL, Jaskiewicz L, Filipowicz W, Sontheimer EJ. ATP modulates siRNA interactions with an endogenous human Dicer complex. Rna (New York, N.Y.). 11: 1719-24. PMID 16177131 DOI: 10.1261/rna.2102805  0.758
2005 Sontheimer EJ, Carthew RW. Silence from within: endogenous siRNAs and miRNAs. Cell. 122: 9-12. PMID 16009127 DOI: 10.1016/j.cell.2005.06.030  0.356
2005 Pham JW, Sontheimer EJ. Separation of Drosophila RNA silencing complexes by native gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 309: 11-6. PMID 15990394 DOI: 10.1385/1-59259-935-4:011  0.719
2005 Sontheimer EJ. Assembly and function of RNA silencing complexes. Nature Reviews. Molecular Cell Biology. 6: 127-38. PMID 15654322 DOI: 10.1038/nrm1568  0.555
2004 He Z, Sontheimer EJ. "siRNAs and miRNAs": a meeting report on RNA silencing. Rna (New York, N.Y.). 10: 1165-73. PMID 15272116 DOI: 10.1261/rna.7900204  0.796
2004 Pham JW, Sontheimer EJ. The Making of an siRNA. Molecular Cell. 15: 163-4. PMID 15260964 DOI: 10.1016/j.molcel.2004.07.002  0.598
2004 Pham JW, Radhakrishnan I, Sontheimer EJ. Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Research. 32: 3446-55. PMID 15247335 DOI: 10.1093/Nar/Gkh658  0.738
2004 Pham JW, Pellino JL, Lee YS, Carthew RW, Sontheimer EJ. A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell. 117: 83-94. PMID 15066284 DOI: 10.1016/S0092-8674(04)00258-2  0.747
2004 Lee YS, Nakahara K, Pham JW, Kim K, He Z, Sontheimer EJ, Carthew RW. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell. 117: 69-81. PMID 15066283 DOI: 10.1016/S0092-8674(04)00261-2  0.787
2003 Pellino JL, Sontheimer EJ. R2D2 leads the silencing trigger to mRNA's death star. Cell. 115: 132-3. PMID 14567910 DOI: 10.1016/S0092-8674(03)00806-7  0.788
2001 Sontheimer EJ. The spliceosome shows its metal Nature Structural Biology. 8: 11-13. PMID 11135658 DOI: 10.1038/82979  0.385
2000 Gordon PM, Sontheimer EJ, Piccirilli JA. Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis. Biochemistry. 39: 12939-52. PMID 11041859 DOI: 10.1021/Bi001089O  0.551
2000 Gordon PM, Sontheimer EJ, Piccirilli JA. Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns. Rna (New York, N.Y.). 6: 199-205. PMID 10688359 DOI: 10.1017/S1355838200992069  0.619
2000 Warnecke JM, Sontheimer EJ, Piccirilli JA, Hartmann RK. Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage. Nucleic Acids Research. 28: 720-7. PMID 10637323 DOI: 10.1093/Nar/28.3.720  0.586
1999 Sontheimer EJ, Gordon PM, Piccirilli JA. Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome. Genes & Development. 13: 1729-41. PMID 10398685 DOI: 10.1101/Gad.13.13.1729  0.587
1999 Sontheimer EJ. Bridging sulfur substitutions in the analysis of Pre-mRNA splicing Methods: a Companion to Methods in Enzymology. 18: 29-37. PMID 10208814 DOI: 10.1006/meth.1999.0754  0.428
1997 Sontheimer EJ, Sun S, Piccirilli JA. Metal ion catalysis during splicing of premessenger RNA. Nature. 388: 801-5. PMID 9285595 DOI: 10.1038/42068  0.615
1994 Sontheimer EJ. Site-specific RNA crosslinking with 4-thiouridine Molecular Biology Reports. 20: 35-44. PMID 7531281 DOI: 10.1007/BF00999853  0.47
1993 Sontheimer EJ, Steitz JA. The U5 and U6 small nuclear RNAs as active site components of the spliceosome Science. 262: 1989-1996. PMID 8266094 DOI: 10.1126/Science.8266094  0.665
1993 Cortes JJ, Sontheimer EJ, Seiwert SD, Steitz JA. Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5' splice sites in vivo. The Embo Journal. 12: 5181-9. PMID 8262061 DOI: 10.1002/J.1460-2075.1993.Tb06213.X  0.546
1992 Gelpi C, Sontheimer EJ, Rodriguez-Sanchez JL. Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proceedings of the National Academy of Sciences of the United States of America. 89: 9739-43. PMID 1409691  0.35
1992 Wyatt JR, Sontheimer EJ, Steitz JA. Site-specific cross-linking of mammalian U5 snRNP to the 5′ splice site before the first step of pre-mRNA splicing Genes and Development. 6: 2542-2553. PMID 1340469 DOI: 10.1101/Gad.6.12B.2542  0.588
1992 Sontheimer EJ, Steitz JA. Three novel functional variants of human U5 small nuclear RNA Molecular and Cellular Biology. 12: 734-746. PMID 1310151 DOI: 10.1128/Mcb.12.2.734  0.62
Low-probability matches (unlikely to be authored by this person)
2022 Chen Z, Devi G, Arif A, Zamore PD, Sontheimer EJ, Watts JK. Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. Acs Chemical Biology. PMID 35446558 DOI: 10.1021/acschembio.2c00116  0.294
2008 Golden DE, Gerbasi VR, Sontheimer EJ. An inside job for siRNAs. Molecular Cell. 31: 309-12. PMID 18691963 DOI: 10.1016/J.Molcel.2008.07.008  0.29
2023 Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, ... Sontheimer EJ, et al. Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing . Biorxiv : the Preprint Server For Biology. PMID 36993169 DOI: 10.1101/2023.03.20.533459  0.288
2012 Kim Guisbert KS, Zhang Y, Flatow J, Hurtado S, Staley JP, Lin S, Sontheimer EJ. Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae. Rna (New York, N.Y.). 18: 1142-53. PMID 22539527 DOI: 10.1261/Rna.030510.111  0.285
2023 Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Amrani N, Chen Z, Gaston N, Wagh A, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, ... ... Sontheimer EJ, et al. Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo. Nucleic Acids Research. PMID 38033325 DOI: 10.1093/nar/gkad1125  0.284
2014 Hurtado S, Kim Guisbert KS, Sontheimer EJ. SPO24 is a transcriptionally dynamic, small ORF-encoding locus required for efficient sporulation in Saccharomyces cerevisiae. Plos One. 9: e105058. PMID 25127041 DOI: 10.1371/journal.pone.0105058  0.271
2019 Garcia B, Lee J, Edraki A, Hidalgo-Reyes Y, Erwood S, Mir A, Trost CN, Seroussi U, Stanley SY, Cohn RD, Claycomb JM, Sontheimer EJ, Maxwell KL, Davidson AR. Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing. Cell Reports. 29: 1739-1746.e5. PMID 31722192 DOI: 10.1016/J.Celrep.2019.10.017  0.264
2016 Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. Naturally Occurring Off-Switches for CRISPR-Cas9. Cell. 167: 1829-1838.e9. PMID 27984730 DOI: 10.1016/J.Cell.2016.11.017  0.243
2017 Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, et al. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Genome Biology. 18: 108. PMID 28615073 DOI: 10.1186/S13059-017-1237-8  0.238
2009 Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim DH, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW. Erratum: Silencing by small RNAs is linked to endosomal trafficking Nature Cell Biology. 11: 1495-1495. DOI: 10.1038/Ncb1209-1495  0.236
2021 Takasugi PR, Wang S, Truong KT, Drage EP, Kanishka SN, Higbee MA, Bamidele N, Ojelabi O, Sontheimer EJ, Gagnon JA. Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos. Genetics. PMID 34735006 DOI: 10.1093/genetics/iyab196  0.22
2023 Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, ... ... Sontheimer EJ, et al. PAM-flexible genome editing with an engineered chimeric Cas9. Nature Communications. 14: 6175. PMID 37794046 DOI: 10.1038/s41467-023-41829-y  0.219
2023 Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, ... ... Sontheimer EJ, et al. CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic Acids Research. PMID 37889041 DOI: 10.1093/nar/gkad890  0.217
2019 Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, et al. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Communications. 10: 2806. PMID 31243272 DOI: 10.1038/S41467-019-10577-3  0.216
2022 Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, ... ... Sontheimer EJ, et al. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro. Nature Communications. 13: 6286. PMID 36271076 DOI: 10.1038/s41467-022-33332-7  0.216
2023 Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez TS, Ponnapati M, Jacobson J, Church G, Truant R, ... ... Sontheimer E, et al. PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Research Square. PMID 36945419 DOI: 10.21203/rs.3.rs-2625838/v1  0.212
2018 Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nature Communications. 9: 4856. PMID 30451839 DOI: 10.1038/S41467-018-07310-X  0.201
2018 Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biology. 19: 137. PMID 30231914 DOI: 10.1186/S13059-018-1515-0  0.2
2018 Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-Pérez JA, Sontheimer EJ. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Molecular Cell. PMID 30581144 DOI: 10.1016/J.Molcel.2018.12.003  0.198
2018 Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, ... ... Sontheimer EJ, et al. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biology. 19: 214. PMID 30518407 DOI: 10.1186/S13059-018-1591-1  0.194
2020 Chatterjee P, Lee J, Nip L, Koseki SRT, Tysinger E, Sontheimer EJ, Jacobson JM, Jakimo N. A Cas9 with PAM recognition for adenine dinucleotides. Nature Communications. 11: 2474. PMID 32424114 DOI: 10.1038/s41467-020-16117-8  0.192
2018 Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. Mbio. 9. PMID 30514786 DOI: 10.1128/Mbio.02321-18  0.186
2017 Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. PMID 28844692 DOI: 10.1016/J.Cell.2017.07.037  0.182
2019 Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, ... Sontheimer EJ, et al. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Molecular Cell. PMID 31668930 DOI: 10.1016/J.Molcel.2019.09.025  0.179
2019 Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ. Tissue-restricted Genome Editing Specified by MicroRNA-repressible Anti-CRISPR Proteins. Rna (New York, N.Y.). PMID 31439808 DOI: 10.1261/Rna.071704.119  0.178
2022 Zhang H, Bamidele N, Liu P, Ojelabi O, Gao XD, Rodriguez T, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Wolfe SA, Xue W, Sontheimer EJ. Adenine Base Editing with a Single Adeno-Associated Virus Vector. Gen Biotechnology. 1: 285-299. PMID 35811581 DOI: 10.1089/genbio.2022.0015  0.177
2023 Kraus C, Sontheimer EJ. Applications of Anti-CRISPR Proteins in Genome Editing and Biotechnology. Journal of Molecular Biology. 435: 168120. PMID 37100169 DOI: 10.1016/j.jmb.2023.168120  0.177
2021 Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nature Communications. 12: 2121. PMID 33837189 DOI: 10.1038/s41467-021-22295-w  0.177
2022 Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodríguez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown JM, Kelly K, Yukselen O, ... ... Sontheimer EJ, et al. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts. Nucleic Acids Research. PMID 35920332 DOI: 10.1093/nar/gkac630  0.172
2020 Chatterjee P, Jakimo N, Lee J, Amrani N, Rodríguez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. An engineered ScCas9 with broad PAM range and high specificity and activity. Nature Biotechnology. PMID 32393822 DOI: 10.1038/S41587-020-0517-0  0.172
2023 Ponnienselvan K, Liu P, Nyalile T, Oikemus S, Joynt AT, Kelly K, Guo D, Chen Z, Lee JM, Schiffer CA, Emerson CP, Lawson ND, Watts JK, Sontheimer EJ, Luban J, et al. Addressing the dNTP bottleneck restricting prime editing activity. Biorxiv : the Preprint Server For Biology. PMID 37904991 DOI: 10.1101/2023.10.21.563443  0.171
2017 Mir A, Edraki A, Lee J, Sontheimer EJ. Type II-C CRISPR-Cas9 Biology, Mechanism, and Application. Acs Chemical Biology. PMID 29202216 DOI: 10.1021/acschembio.7b00855  0.17
2023 Bamidele N, Zhang H, Dong X, Gaston N, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Sontheimer EJ. Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. Biorxiv : the Preprint Server For Biology. PMID 37131611 DOI: 10.1101/2023.04.14.536905  0.168
2017 Sontheimer EJ, Davidson AR. Inhibition of CRISPR-Cas systems by mobile genetic elements. Current Opinion in Microbiology. 37: 120-127. PMID 28668720 DOI: 10.1016/j.mib.2017.06.003  0.167
2023 Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA. Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Nature Methods. PMID 37156841 DOI: 10.1038/s41592-023-01859-2  0.167
2024 Bamidele N, Zhang H, Dong X, Cheng H, Gaston N, Feinzig H, Cao H, Kelly K, Watts JK, Xie J, Gao G, Sontheimer EJ. Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope. Nature Communications. 15: 1458. PMID 38368418 DOI: 10.1038/s41467-024-45763-5  0.163
2020 Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Annual Review of Biochemistry. PMID 32186918 DOI: 10.1146/annurev-biochem-011420-111224  0.158
2023 Zheng C, Liu B, Dong X, Gaston N, Sontheimer EJ, Xue W. Template-jumping prime editing enables large insertion and exon rewriting in vivo. Nature Communications. 14: 3369. PMID 37291100 DOI: 10.1038/s41467-023-39137-6  0.158
2023 Chen Z, Kwan SY, Mir A, Hazeltine M, Shin M, Liang SQ, Chan IL, Kelly K, Ghanta KS, Gaston N, Cao Y, Xie J, Gao G, Xue W, Sontheimer EJ, et al. A Fluorescent Reporter Mouse for Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors. The Crispr Journal. 6: 570-582. PMID 38108517 DOI: 10.1089/crispr.2023.0048  0.15
2022 Liang SQ, Liu P, Smith JL, Mintzer E, Maitland S, Dong X, Yang Q, Lee J, Haynes CM, Zhu LJ, Watts JK, Sontheimer EJ, Wolfe SA, Xue W. Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Nature Communications. 13: 437. PMID 35064134 DOI: 10.1038/s41467-022-28135-9  0.148
2020 Barrangou R, Sontheimer EJ. CRISPR Shields: Fending Off Diverse Cas Nucleases with Nucleus-like Structures. Molecular Cell. 77: 934-936. PMID 32142691 DOI: 10.1016/j.molcel.2020.02.015  0.138
2021 Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, ... ... Sontheimer E, et al. 5' modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 10. PMID 34665130 DOI: 10.7554/eLife.72216  0.138
2022 Iyer S, Mir A, Vega-Badillo J, Roscoe BP, Ibraheim R, Zhu LJ, Lee J, Liu P, Luk K, Mintzer E, Guo D, Soares de Brito J, Emerson CP, Zamore PD, Sontheimer EJ, et al. Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors. The Crispr Journal. PMID 36070530 DOI: 10.1089/crispr.2022.0058  0.134
2023 Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ. Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Nature Biotechnology. PMID 37709915 DOI: 10.1038/s41587-023-01947-w  0.132
2022 Rodríguez TC, Kwan S, Smith JL, Dadafarin S, Wu CH, Sontheimer EJ, Xue W. Multi-omics characterization of mouse hepatoblastoma identifies novel YAP1 target genes. Hepatology (Baltimore, Md.). PMID 35932276 DOI: 10.1002/hep.32713  0.13
2018 Edraki A, Sontheimer EJ. CRISPRs from scratch. Nature Microbiology. 3: 261-262. PMID 29463924 DOI: 10.1038/s41564-018-0115-9  0.129
2014 Zhang Y, Sontheimer EJ. Structural biology. Cascading into focus. Science (New York, N.Y.). 345: 1452-3. PMID 25237089 DOI: 10.1126/science.1260026  0.129
2018 Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure (London, England : 1993). PMID 29779790 DOI: 10.1016/J.Str.2018.04.008  0.124
2015 Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Human Gene Therapy. 26: 432-42. PMID 26086867 DOI: 10.1089/Hum.2015.087  0.12
2015 Sontheimer EJ, Wolfe SA. Cas9 gets a classmate. Nature Biotechnology. 33: 1240-1241. PMID 26650011 DOI: 10.1038/nbt.3426  0.119
2021 Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodríguez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, ... ... Sontheimer EJ, et al. Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Nature Communications. 12: 6267. PMID 34725353 DOI: 10.1038/s41467-021-26518-y  0.101
2019 Sontheimer EJ. X-Tracting a New CRISPR-Cas Genome-Editing Platform from Metagenomic Data Sets. The Crispr Journal. 2: 148-150. PMID 31225753 DOI: 10.1089/crispr.2019.29061.ejs  0.089
2024 McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Escude Velasco B, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, et al. Modular vector assembly enables rapid assessment of emerging CRISPR technologies. Cell Genomics. 4: 100519. PMID 38484704 DOI: 10.1016/j.xgen.2024.100519  0.079
2014 Doudna JA, Sontheimer EJ. Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods in Enzymology. 546: xix-xx. PMID 25398356 DOI: 10.1016/B978-0-12-801185-0.09983-9  0.079
2023 McGee AV, Liu YV, Griffith AL, Szegletes ZM, Wen B, Kraus C, Miller NW, Steger RJ, Velasco BE, Bosch JA, Zirin JD, Viswanatha R, Sontheimer EJ, Goodale A, Greene MA, et al. Modular vector assembly enables rapid assessment of emerging CRISPR technologies. Biorxiv : the Preprint Server For Biology. PMID 37961518 DOI: 10.1101/2023.10.25.564061  0.079
2018 Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nature Methods. PMID 29735996 DOI: 10.1038/S41592-018-0006-2  0.078
2021 Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1  0.074
2020 Smith JL, Rodríguez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W. YAP1 withdrawal in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells. Hepatology (Baltimore, Md.). PMID 32452550 DOI: 10.1002/Hep.31389  0.069
2021 Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, ... ... Sontheimer EJ, et al. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nature Communications. 12: 6931. PMID 34836963 DOI: 10.1038/s41467-021-27190-y  0.068
2018 Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nature Communications. 9: 5294. PMID 30531933 DOI: 10.1038/S41467-018-07776-9  0.05
2004 Sontheimer EJ, Carthew RW. Molecular biology. Argonaute journeys into the heart of RISC. Science (New York, N.Y.). 305: 1409-10. PMID 15353786 DOI: 10.1126/science.1103076  0.05
2020 Chatterjee P, Jakimo N, Lee J, Amrani N, Rodríguez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity. Nature Biotechnology. PMID 32561876 DOI: 10.1038/S41587-020-0604-2  0.027
2015 Sontheimer E. Accelerating expansion. Rna (New York, N.Y.). 21: 510. PMID 25780117 DOI: 10.1261/rna.050682.115  0.026
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