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Brian D. Ames, Ph.D. - Publications

Affiliations: 
2004-2009 Biological Sciences - Ph.D. University of California, Irvine, Irvine, CA 
 2009-2011 Biological Chemistry and Molecular Pharmacology - Postdoc Harvard Medical School, Boston, MA, United States 
 2011-2019 Cardiovascular and Metabolic Diseases Novartis Institutes for BioMedical Research, Cambridge, MA, United States 
Area:
Biochemistry, Molecular Biology, Microbiology Biology
Website:
https://www.linkedin.com/in/brian-ames-ab53b713/
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16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Lim FY, Ames B, Walsh CT, Keller NP. Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus. Cellular Microbiology. 16: 1267-83. PMID 24612080 DOI: 10.1111/Cmi.12284  0.619
2013 Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y. Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks. Acs Chemical Biology. 8: 1366-82. PMID 23659680 DOI: 10.1021/Cb4001684  0.556
2012 Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y. Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain. Nature Chemical Biology. 8: 823-30. PMID 22902615 DOI: 10.1038/Nchembio.1047  0.583
2012 Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/Pnas.1113029109  0.669
2012 Lee MY, Ames BD, Tsai SC. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 51: 3079-91. PMID 22432862 DOI: 10.1021/Bi201705Q  0.764
2012 Walsh CT, Haynes SW, Ames BD. Aminobenzoates as building blocks for natural product assembly lines. Natural Product Reports. 29: 37-59. PMID 22064917 DOI: 10.1039/C1Np00072A  0.566
2011 Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT. Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus. Biochemistry. 50: 8756-69. PMID 21899262 DOI: 10.1021/Bi201302W  0.679
2011 Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 50: 8392-406. PMID 21870821 DOI: 10.1021/Bi200593M  0.735
2011 Zhang W, Ames BD, Walsh CT. Identification of phenylalanine 3-hydroxylase for meta-tyrosine biosynthesis. Biochemistry. 50: 5401-3. PMID 21615132 DOI: 10.1021/Bi200733C  0.611
2011 Haynes SW, Ames BD, Gao X, Tang Y, Walsh CT. Unraveling terminal C-domain-mediated condensation in fungal biosynthesis of imidazoindolone metabolites. Biochemistry. 50: 5668-79. PMID 21591693 DOI: 10.1021/Bi2004922  0.613
2011 Gao X, Chooi YH, Ames BD, Wang P, Walsh CT, Tang Y. Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. Journal of the American Chemical Society. 133: 2729-41. PMID 21299212 DOI: 10.1021/Ja1101085  0.618
2010 Ames BD, Liu X, Walsh CT. Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis. Biochemistry. 49: 8564-76. PMID 20804163 DOI: 10.1021/Bi1012029  0.563
2010 Ames BD, Walsh CT. Anthranilate-activating modules from fungal nonribosomal peptide assembly lines. Biochemistry. 49: 3351-65. PMID 20225828 DOI: 10.1021/Bi100198Y  0.517
2009 Tsai SC, Ames BD. Structural enzymology of polyketide synthases. Methods in Enzymology. 459: 17-47. PMID 19362634 DOI: 10.1016/S0076-6879(09)04602-3  0.708
2008 Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proceedings of the National Academy of Sciences of the United States of America. 105: 5349-54. PMID 18388203 DOI: 10.1073/Pnas.0709223105  0.766
2006 Zhang W, Ames BD, Tsai SC, Tang Y. Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Applied and Environmental Microbiology. 72: 2573-80. PMID 16597959 DOI: 10.1128/Aem.72.4.2573-2580.2006  0.709
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