| Year |
Citation |
Score |
| 2016 |
Sawynok J, Zinger C. Topical amitriptyline and ketamine for post-herpetic neuralgia and other forms of neuropathic pain. Expert Opinion On Pharmacotherapy. PMID 26809783 DOI: 10.1517/14656566.2016.1146691 |
0.345 |
|
| 2015 |
Sawynok J. Adenosine receptor targets for pain. Neuroscience. PMID 26500181 DOI: 10.1016/j.neuroscience.2015.10.031 |
0.477 |
|
| 2015 |
Nascimento FP, Macedo-Júnior SJ, Pamplona FA, Luiz-Cerutti M, Córdova MM, Constantino L, Tasca CI, Dutra RC, Calixto JB, Reid A, Sawynok J, Santos AR. Adenosine A1 receptor-dependent antinociception induced by inosine in mice: pharmacological, genetic and biochemical aspects. Molecular Neurobiology. 51: 1368-78. PMID 25064055 DOI: 10.1007/S12035-014-8815-5 |
0.41 |
|
| 2014 |
Sawynok J. Topical and peripheral ketamine as an analgesic. Anesthesia and Analgesia. 119: 170-8. PMID 24945127 DOI: 10.1213/ANE.0000000000000246 |
0.45 |
|
| 2014 |
Sawynok J, Liu J. Contributions of peripheral, spinal, and supraspinal actions to analgesia. European Journal of Pharmacology. 734: 114-21. PMID 24731877 DOI: 10.1016/j.ejphar.2014.04.006 |
0.377 |
|
| 2014 |
Sawynok J. Topical analgesics for neuropathic pain: preclinical exploration, clinical validation, future development. European Journal of Pain (London, England). 18: 465-81. PMID 24108446 DOI: 10.1002/j.1532-2149.2013.00400.x |
0.367 |
|
| 2013 |
Sawynok J, Reid AR, Liu J. Spinal and peripheral adenosine Aâ‚ receptors contribute to antinociception by tramadol in the formalin test in mice. European Journal of Pharmacology. 714: 373-8. PMID 23872384 DOI: 10.1016/j.ejphar.2013.07.012 |
0.498 |
|
| 2013 |
Liu J, Reid AR, Sawynok J. Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors. Neuroscience Letters. 536: 64-8. PMID 23313594 DOI: 10.1016/j.neulet.2012.12.052 |
0.413 |
|
| 2013 |
Liu J, Reid AR, Sawynok J. Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline. European Journal of Pharmacology. 698: 213-9. PMID 23142373 DOI: 10.1016/j.ejphar.2012.10.042 |
0.436 |
|
| 2012 |
Sawynok J, Reid AR. Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine Aâ‚ receptors. European Journal of Pharmacology. 674: 248-54. PMID 22085758 DOI: 10.1016/j.ejphar.2011.10.036 |
0.514 |
|
| 2011 |
Watson CP, Gilron I, Sawynok J, Lynch ME. Nontricyclic antidepressant analgesics and pain: are serotonin norepinephrine reuptake inhibitors (SNRIs) any better? Pain. 152: 2206-10. PMID 21723037 DOI: 10.1016/j.pain.2011.05.032 |
0.387 |
|
| 2011 |
Sawynok J, Reid AR. Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model. Neuroscience Letters. 494: 99-103. PMID 21371525 DOI: 10.1016/j.neulet.2011.02.067 |
0.397 |
|
| 2011 |
Sawynok J. Caffeine and pain. Pain. 152: 726-9. PMID 21041029 DOI: 10.1016/j.pain.2010.10.011 |
0.43 |
|
| 2011 |
Sawynok J. Methylxanthines and pain. Handbook of Experimental Pharmacology. 311-29. PMID 20859801 DOI: 10.1007/978-3-642-13443-2_11 |
0.501 |
|
| 2010 |
Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. Neuroscience Letters. 473: 178-81. PMID 20176083 DOI: 10.1016/j.neulet.2010.02.028 |
0.442 |
|
| 2009 |
Arsenault A, Sawynok J. Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury. Pain. 146: 308-14. PMID 19748184 DOI: 10.1016/j.pain.2009.08.003 |
0.349 |
|
| 2008 |
Meisner JG, Reid AR, Sawynok J. Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury. Neuroscience Letters. 444: 172-5. PMID 18722504 DOI: 10.1016/j.neulet.2008.08.032 |
0.415 |
|
| 2008 |
Sawynok J, Reid AR, Fredholm BB. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. Neuroscience Letters. 440: 181-4. PMID 18562097 DOI: 10.1016/j.neulet.2008.05.074 |
0.392 |
|
| 2008 |
Sullivan MJL, Lynch ME, Clark AJ, Mankovsky T, Sawynok J. Catastrophizing and treatment outcome: Differential impact on response to placebo and active treatment outcome Contemporary Hypnosis. 25: 129-140. DOI: 10.1002/ch.365 |
0.302 |
|
| 2007 |
Meisner JG, Waldron JB, Sawynok J. Alpha1-adrenergic receptors augment P2X3 receptor-mediated nociceptive responses in the uninjured state. The Journal of Pain : Official Journal of the American Pain Society. 8: 556-62. PMID 17512257 DOI: 10.1016/j.jpain.2007.02.434 |
0.383 |
|
| 2007 |
Sawynok J. Adenosine and ATP receptors. Handbook of Experimental Pharmacology. 309-28. PMID 17087128 DOI: 10.1007/978-3-540-33823-9_11 |
0.397 |
|
| 2006 |
Sawynok J, Reid A, Meisner J. Pain behaviors produced by capsaicin: influence of inflammatory mediators and nerve injury. The Journal of Pain : Official Journal of the American Pain Society. 7: 134-41. PMID 16459279 DOI: 10.1016/j.jpain.2005.09.013 |
0.415 |
|
| 2005 |
Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical amitriptyline and ketamine in neuropathic pain syndromes: an open-label study. The Journal of Pain : Official Journal of the American Pain Society. 6: 644-9. PMID 16202956 DOI: 10.1016/j.jpain.2005.04.008 |
0.343 |
|
| 2005 |
Sawynok J. Topical analgesics in neuropathic pain. Current Pharmaceutical Design. 11: 2995-3004. PMID 16178758 DOI: 10.2174/1381612054865019 |
0.348 |
|
| 2005 |
Sawynok J, Reid AR, Liu XJ, Parkinson FE. Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake. European Journal of Pharmacology. 518: 116-22. PMID 16156010 DOI: 10.1016/j.ejphar.2005.06.030 |
0.402 |
|
| 2005 |
Lynch ME, Clark AJ, Sawynok J, Sullivan MJ. Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: a randomized, double-blind, placebo-controlled trial. Anesthesiology. 103: 140-6. PMID 15983466 DOI: 10.1097/00000542-200507000-00021 |
0.331 |
|
| 2004 |
Waldron JB, Reid AR, Sawynok J. Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors. European Journal of Pharmacology. 499: 275-83. PMID 15381049 DOI: 10.1016/j.ejphar.2004.07.116 |
0.443 |
|
| 2004 |
Waldron JB, Sawynok J. Peripheral P2X receptors and nociception: interactions with biogenic amine systems. Pain. 110: 79-89. PMID 15275755 DOI: 10.1016/j.pain.2004.03.012 |
0.419 |
|
| 2004 |
Aumeerally N, Allen G, Sawynok J. Glutamate-evoked release of adenosine and regulation of peripheral nociception. Neuroscience. 127: 1-11. PMID 15219663 DOI: 10.1016/j.neuroscience.2004.04.012 |
0.467 |
|
| 2004 |
Eisenach JC, Hood DD, Curry R, Sawynok J, Yaksh TL, Li X. Intrathecal but not intravenous opioids release adenosine from the spinal cord. The Journal of Pain : Official Journal of the American Pain Society. 5: 64-8. PMID 14975380 DOI: 10.1016/j.jpain.2003.10.001 |
0.481 |
|
| 2003 |
Oatway M, Reid A, Sawynok J. Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat. Anesthesia and Analgesia. 97: 168-73, table of con. PMID 12818961 DOI: 10.1213/01.Ane.0000067406.52093.Bf |
0.36 |
|
| 2003 |
Sawynok J, Liu XJ. Adenosine in the spinal cord and periphery: release and regulation of pain. Progress in Neurobiology. 69: 313-40. PMID 12787573 DOI: 10.1016/S0301-0082(03)00050-9 |
0.527 |
|
| 2003 |
Lynch ME, Clark AJ, Sawynok J. Intravenous adenosine alleviates neuropathic pain: a double blind placebo controlled crossover trial using an enriched enrolment design. Pain. 103: 111-7. PMID 12749965 DOI: 10.1016/S0304-3959(02)00419-0 |
0.359 |
|
| 2003 |
Sawynok J, Reid A. Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. Pain. 102: 179-86. PMID 12620609 DOI: 10.1016/s0304-3959(02)00373-1 |
0.439 |
|
| 2003 |
Sawynok J. Topical and peripherally acting analgesics. Pharmacological Reviews. 55: 1-20. PMID 12615951 DOI: 10.1124/pr.55.1.1 |
0.447 |
|
| 2002 |
Sawynok J, Reid A. Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. European Journal of Pharmacology. 450: 153-62. PMID 12206853 DOI: 10.1016/S0014-2999(02)02119-2 |
0.436 |
|
| 2002 |
Liu XJ, White TD, Sawynok J. Enhanced release of adenosine in rat hind paw following spinal nerve ligation: involvement of capsaicin-sensitive sensory afferents. Neuroscience. 114: 379-87. PMID 12204207 DOI: 10.1016/S0306-4522(02)00295-6 |
0.445 |
|
| 2002 |
Heughan CE, Sawynok J. The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. Anesthesia and Analgesia. 94: 975-80, table of con. PMID 11916807 DOI: 10.1097/00000539-200204000-00037 |
0.35 |
|
| 2002 |
Liu XJ, White TD, Sawynok J. Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents. Journal of Neurochemistry. 80: 562-70. PMID 11841563 DOI: 10.1046/j.0022-3042.2001.00721.x |
0.446 |
|
| 2002 |
Heughan CE, Allen GV, Chase TD, Sawynok J. Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. Anesthesia and Analgesia. 94: 427-31, table of con. PMID 11812713 DOI: 10.1213/00000539-200202000-00038 |
0.441 |
|
| 2001 |
Esser MJ, Chase T, Allen GV, Sawynok J. Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions. European Journal of Pharmacology. 430: 211-8. PMID 11711033 DOI: 10.1016/S0014-2999(01)01276-6 |
0.45 |
|
| 2001 |
Liu XJ, White TD, Sawynok J. Involvement of primary sensory afferents, postganglionic sympathetic nerves and mast cells in the formalin-evoked peripheral release of adenosine. European Journal of Pharmacology. 429: 147-55. PMID 11698037 DOI: 10.1016/S0014-2999(01)01316-4 |
0.406 |
|
| 2001 |
Sawynok J, Reid A. Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration. Pain. 93: 51-9. PMID 11406338 DOI: 10.1016/S0304-3959(01)00291-3 |
0.414 |
|
| 2001 |
Sawynok J, Esser MJ, Reid AR. Antidepressants as analgesics: an overview of central and peripheral mechanisms of action. Journal of Psychiatry & Neuroscience : Jpn. 26: 21-9. PMID 11212590 |
0.374 |
|
| 2000 |
Liu XJ, White TD, Sawynok J. Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: a microdialysis study. European Journal of Pharmacology. 408: 143-52. PMID 11080520 DOI: 10.1016/S0014-2999(00)00742-1 |
0.413 |
|
| 2000 |
Esser MJ, Sawynok J. Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain. European Journal of Pharmacology. 399: 131-9. PMID 10884512 DOI: 10.1016/S0014-2999(00)00336-8 |
0.476 |
|
| 2000 |
Sawynok J, Reid A, Liu XJ. Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A(1) and A(2B/3) receptor agonists. European Journal of Pharmacology. 395: 47-50. PMID 10781673 DOI: 10.1016/S0014-2999(00)00125-4 |
0.334 |
|
| 1999 |
Sawynok J, Reid A, Liu XJ. Acute paw oedema induced by local injection of adenosine A(1), A(2) and A(3) receptor agonists. European Journal of Pharmacology. 386: 253-61. PMID 10618477 DOI: 10.1016/S0014-2999(99)00752-9 |
0.357 |
|
| 1999 |
Poon A, Sawynok J. Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor. European Journal of Pharmacology. 384: 123-38. PMID 10611432 DOI: 10.1016/S0014-2999(99)00626-3 |
0.491 |
|
| 1999 |
Sawynok J, Esser MJ, Reid AR. Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. Pain. 82: 149-58. PMID 10467920 DOI: 10.1016/S0304-3959(99)00043-3 |
0.491 |
|
| 1999 |
Esser MJ, Sawynok J. Acute amitriptyline in a rat model of neuropathic pain: differential symptom and route effects. Pain. 80: 643-53. PMID 10342426 DOI: 10.1016/S0304-3959(98)00261-9 |
0.45 |
|
| 1999 |
Sawynok J, Reid AR, Esser MJ. Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine. Pain. 80: 45-55. PMID 10204717 DOI: 10.1016/S0304-3959(98)00195-X |
0.466 |
|
| 1998 |
Sawynok J. Adenosine receptor activation and nociception. European Journal of Pharmacology. 347: 1-11. PMID 9650842 DOI: 10.1016/S0014-2999(97)01605-1 |
0.508 |
|
| 1998 |
Poon A, Sawynok J. Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat. Pain. 74: 235-45. PMID 9520238 DOI: 10.1016/S0304-3959(97)00186-3 |
0.486 |
|
| 1998 |
Sawynok J, Reid A, Poon A. Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test. Pain. 74: 75-81. PMID 9514563 DOI: 10.1016/S0304-3959(97)00153-X |
0.468 |
|
| 1998 |
Sawynok J, Doak G, Poon A. Adenosine and pain: Recent findings with directly and indirectly acting agents Drug Development Research. 45: 304-311. DOI: 10.1002/(Sici)1098-2299(199811/12)45:3/4<304::Aid-Ddr29>3.0.Co;2-L |
0.505 |
|
| 1997 |
Sawynok J, Zarrindast MR, Reid AR, Doak GJ. Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. European Journal of Pharmacology. 333: 1-7. PMID 9311654 DOI: 10.1016/S0014-2999(97)01110-2 |
0.433 |
|
| 1997 |
Doak GJ, Sawynok J. Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes. Neuroscience. 80: 939-49. PMID 9276504 DOI: 10.1016/S0306-4522(97)00066-3 |
0.415 |
|
| 1997 |
Sawynok J, Reid A. Peripheral adenosine 5'-triphosphate enhances nociception in the formalin test via activation of a purinergic p2X receptor. European Journal of Pharmacology. 330: 115-21. PMID 9253943 DOI: 10.1016/S0014-2999(97)01001-7 |
0.404 |
|
| 1997 |
Cahill CM, White TD, Sawynok J. Substance P releases and augments the morphine-evoked release of adenosine from spinal cord. Brain Research. 760: 294-7. PMID 9237551 DOI: 10.1016/S0006-8993(97)00473-3 |
0.577 |
|
| 1996 |
Cahill CM, White TD, Sawynok J. Synergy between mu/delta-opioid receptors mediates adenosine release from spinal cord synaptosomes. European Journal of Pharmacology. 298: 45-9. PMID 8867918 DOI: 10.1016/0014-2999(95)00775-X |
0.609 |
|
| 1996 |
Sawynok J, Reid A. Caffeine antinociception: role of formalin concentration and adenosine A1 and A2 receptors. European Journal of Pharmacology. 298: 105-11. PMID 8867096 DOI: 10.1016/0014-2999(95)00791-1 |
0.387 |
|
| 1996 |
Golembiowska K, White TD, Sawynok J. Adenosine kinase inhibitors augment release of adenosine from spinal cord slices. European Journal of Pharmacology. 307: 157-62. PMID 8832217 DOI: 10.1016/0014-2999(96)00248-8 |
0.361 |
|
| 1996 |
Sawynok J, Reid A. Interactions of descending serotonergic systems with other neurotransmitters in the modulation of nociception. Behavioural Brain Research. 73: 63-8. PMID 8788479 DOI: 10.1016/0166-4328(96)00072-1 |
0.39 |
|
| 1996 |
Sawynok J, Reid A. Neurotoxin-induced lesions to central serotonergic, noradrenergic and dopaminergic systems modify caffeine-induced antinociception in the formalin test and locomotor stimulation in rats. The Journal of Pharmacology and Experimental Therapeutics. 277: 646-53. PMID 8627541 |
0.304 |
|
| 1995 |
Golembiowska K, White TD, Sawynok J. Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors. Brain Research. 699: 315-20. PMID 8616636 DOI: 10.1016/0006-8993(95)00926-H |
0.479 |
|
| 1995 |
Poon A, Sawynok J. Antinociception by adenosine analogs and an adenosine kinase inhibitor: dependence on formalin concentration. European Journal of Pharmacology. 286: 177-84. PMID 8605954 DOI: 10.1016/0014-2999(95)00444-P |
0.475 |
|
| 1995 |
Doak GJ, Sawynok J. Complex role of peripheral adenosine in the genesis of the response to subcutaneous formalin in the rat. European Journal of Pharmacology. 281: 311-8. PMID 8521915 DOI: 10.1016/0014-2999(95)00257-L |
0.416 |
|
| 1995 |
Sawynok J. Pharmacological rationale for the clinical use of caffeine. Drugs. 49: 37-50. PMID 7705215 DOI: 10.2165/00003495-199549010-00004 |
0.376 |
|
| 1995 |
Sawynok J, Reid AR, Doak GJ. Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. Pain. 61: 203-13. PMID 7659430 DOI: 10.1016/0304-3959(94)00169-F |
0.462 |
|
| 1995 |
Cahill CM, White TD, Sawynok J. Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of opioid subtypes. The Journal of Pharmacology and Experimental Therapeutics. 275: 84-93. PMID 7562600 |
0.586 |
|
| 1994 |
Sawynok J, Reid A. Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine. European Journal of Pharmacology. 264: 249-57. PMID 7698162 DOI: 10.1016/0014-2999(94)00465-X |
0.313 |
|
| 1993 |
Sawynok J, Downie JW, Reid AR, Cahill CM, White TD. ATP release from dorsal spinal cord synaptosomes: characterization and neuronal origin. Brain Research. 610: 32-8. PMID 8518929 DOI: 10.1016/0006-8993(93)91213-C |
0.584 |
|
| 1993 |
Sweeney MI, White TD, Sawynok J. Morphine-evoked release of adenosine from the spinal cord occurs via a nucleoside carrier with differential sensitivity to dipyridamole and nitrobenzylthioinosine. Brain Research. 614: 301-7. PMID 8348322 DOI: 10.1016/0006-8993(93)90444-R |
0.475 |
|
| 1993 |
Cahill CM, White TD, Sawynok J. Influence of calcium on the release of endogenous adenosine from spinal cord synaptosomes. Life Sciences. 53: 487-96. PMID 8341135 DOI: 10.1016/0024-3205(93)90700-D |
0.599 |
|
| 1993 |
Cahill CM, White TD, Sawynok J. Morphine activates omega-conotoxin-sensitive Ca2+ channels to release adenosine from spinal cord synaptosomes. Journal of Neurochemistry. 60: 894-901. PMID 7679729 DOI: 10.1111/j.1471-4159.1993.tb03234.x |
0.596 |
|
| 1993 |
Cahill CM, White TD, Sawynok J. Involvement of calcium channels in depolarization-evoked release of adenosine from spinal cord synaptosomes. Journal of Neurochemistry. 60: 886-93. PMID 7679728 DOI: 10.1111/J.1471-4159.1993.Tb03233.X |
0.555 |
|
| 1992 |
Sawynok J, Reid A. Desipramine potentiates spinal antinociception by 5-hydroxytryptamine, morphine and adenosine. Pain. 50: 113-8. PMID 1513600 DOI: 10.1016/0304-3959(92)90118-U |
0.481 |
|
| 1992 |
Sawynok J, Reid A. Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes. European Journal of Pharmacology. 223: 49-56. PMID 1362158 DOI: 10.1016/0014-2999(92)90817-N |
0.446 |
|
| 1991 |
Sawynok J, Reid A, Nance D. Spinal antinociception by adenosine analogs and morphine after intrathecal administration of the neurotoxins capsaicin, 6-hydroxydopamine and 5,7-dihydroxytryptamine. The Journal of Pharmacology and Experimental Therapeutics. 258: 370-80. PMID 1906540 |
0.428 |
|
| 1991 |
Sawynok J, Espey MJ, Reid A. 8-Phenyltheophylline reverses the antinociceptive action of morphine in the periaqueductal gray. Neuropharmacology. 30: 871-7. PMID 1780044 DOI: 10.1016/0028-3908(91)90121-Q |
0.501 |
|
| 1991 |
Nicholson D, White TD, Sawynok J. Forskolin and phosphodiesterase inhibitors release adenosine but inhibit morphine-evoked release of adenosine from spinal cord synaptosomes. Canadian Journal of Physiology and Pharmacology. 69: 877-85. PMID 1717120 DOI: 10.1139/Y91-133 |
0.486 |
|
| 1991 |
Nicholson D, Reid A, Sawynok J. Effects of forskolin and phosphodiesterase inhibitors on spinal antinociception by morphine. Pharmacology, Biochemistry, and Behavior. 38: 753-8. PMID 1714608 DOI: 10.1016/0091-3057(91)90237-V |
0.485 |
|
| 1991 |
Sawynok J, Reid A. Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine. European Journal of Pharmacology. 204: 301-9. PMID 1663459 DOI: 10.1016/0014-2999(91)90856-L |
0.354 |
|
| 1991 |
Sweeney MI, White TD, Sawynok J. Intracerebroventricular morphine releases adenosine and adenosine 3',5'-cyclic monophosphate from the spinal cord via a serotonergic mechanism. The Journal of Pharmacology and Experimental Therapeutics. 259: 1013-8. PMID 1662270 |
0.394 |
|
| 1990 |
Sawynok J, Reid A. Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites. Naunyn-Schmiedeberg's Archives of Pharmacology. 342: 1-8. PMID 2402297 DOI: 10.1007/BF00178964 |
0.399 |
|
| 1990 |
Sawynok J, Sweeney M, Nicholson D, White T. Pertussis toxin inhibits morphine-induced release of adenosine from the spinal cord. Progress in Clinical and Biological Research. 328: 397-400. PMID 2304959 |
0.377 |
|
| 1990 |
Sweeney MI, White TD, Sawynok J. 5-Hydroxytryptamine releases adenosine and cyclic AMP from primary afferent nerve terminals in the spinal cord in vivo. Brain Research. 528: 55-61. PMID 2173965 DOI: 10.1016/0006-8993(90)90194-G |
0.461 |
|
| 1990 |
Sawynok J, Reid A, Isbrucker R. Adenosine mediates calcium-induced antinociception and potentiation of noradrenergic antinociception in the spinal cord. Brain Research. 524: 187-95. PMID 2127235 DOI: 10.1016/0006-8993(90)90689-9 |
0.497 |
|
| 1990 |
Sawynok J, Nicholson DJ, Sweeney MI, White TD. Adenosine release by morphine and spinal antinociception: role of G-proteins and cyclic AMP. Nida Research Monograph. 105: 40-6. PMID 1652084 |
0.329 |
|
| 1990 |
Sweeney MI, White TD, Sawynok J. Intracerebroventricular morphine releases cyclic AMP and adenosine from the spinal cord via a serotonergic mechanism European Journal of Pharmacology. 183: 1450-1451. DOI: 10.1016/0014-2999(90)94589-P |
0.471 |
|
| 1989 |
Sawynok J, Sweeney MI. The role of purines in nociception. Neuroscience. 32: 557-69. PMID 2689906 DOI: 10.1016/0306-4522(89)90278-9 |
0.496 |
|
| 1989 |
Sawynok J. The 1988 Merck Frosst Award. The role of ascending and descending noradrenergic and serotonergic pathways in opioid and non-opioid antinociception as revealed by lesion studies. Canadian Journal of Physiology and Pharmacology. 67: 975-88. PMID 2688867 DOI: 10.1139/Y89-154 |
0.388 |
|
| 1989 |
Sawynok J, Sweeney MI, White TD. Adenosine release may mediate spinal analgesia by morphine. Trends in Pharmacological Sciences. 10: 186-9. PMID 2667227 DOI: 10.1016/0165-6147(89)90235-6 |
0.515 |
|
| 1989 |
Sawynok J, Reid A. Lesions to ascending noradrenergic and serotonergic pathways modify antinociception produced by intracerebroventricular administration of morphine. Neuropharmacology. 28: 141-7. PMID 2497401 DOI: 10.1016/0028-3908(89)90050-6 |
0.436 |
|
| 1989 |
Sweeney MI, White TD, Sawynok J. Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord. The Journal of Pharmacology and Experimental Therapeutics. 248: 447-54. PMID 2492344 |
0.394 |
|
| 1988 |
Sawynok J, Reid A. Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 359-65. PMID 3405312 DOI: 10.1007/BF00169524 |
0.352 |
|
| 1988 |
Hoehn K, Reid A, Sawynok J. Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen. European Journal of Pharmacology. 146: 65-72. PMID 3350059 DOI: 10.1016/0014-2999(88)90487-6 |
0.472 |
|
| 1988 |
Sweeney M, White T, Sawynok J. 5-Hydroxytryptamine releases adenosine from primary afferent nerve terminals in the spinal cord. Brain Research. 462: 346-9. PMID 3191394 DOI: 10.1016/0006-8993(88)90562-8 |
0.46 |
|
| 1988 |
Sawynok J, Reid A. Role of G-proteins and adenylate cyclase in antinociception produced by intrathecal purines. European Journal of Pharmacology. 156: 25-34. PMID 3145208 DOI: 10.1016/0014-2999(88)90143-4 |
0.45 |
|
| 1987 |
Sweeney MI, White TD, Jhamandas KH, Sawynok J. Morphine releases endogenous adenosine from the spinal cord in vivo. European Journal of Pharmacology. 141: 169-70. PMID 3666024 DOI: 10.1016/0014-2999(87)90428-6 |
0.464 |
|
| 1987 |
Duan J, Sawynok J. Enhancement of clonidine-induced analgesia by lesions induced with spinal and intracerebroventricular administration of 5,7-dihydroxytryptamine. Neuropharmacology. 26: 323-9. PMID 3587536 DOI: 10.1016/0028-3908(87)90184-5 |
0.424 |
|
| 1987 |
Sawynok J, Reid A. Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia. Brain Research. 419: 156-65. PMID 3119144 DOI: 10.1016/0006-8993(87)90579-8 |
0.427 |
|
| 1987 |
Sawynok J. GABAergic mechanisms of analgesia: an update. Pharmacology, Biochemistry, and Behavior. 26: 463-74. PMID 3033701 DOI: 10.1016/0091-3057(87)90148-1 |
0.459 |
|
| 1987 |
Sweeney MI, White TD, Sawynok J. Involvement of adenosine in the spinal antinociceptive effects of morphine and noradrenaline. The Journal of Pharmacology and Experimental Therapeutics. 243: 657-65. PMID 2824755 |
0.425 |
|
| 1987 |
Nance PW, Sawynok J. Substance P-induced long-term blockade of spinal adrenergic analgesia: reversal by morphine and naloxone. The Journal of Pharmacology and Experimental Therapeutics. 240: 972-7. PMID 2435888 |
0.337 |
|
| 1986 |
Sawynok J, Reid A. Role of ascending and descending noradrenergic pathways in the antinociceptive effect of baclofen and clonidine. Brain Research. 386: 341-50. PMID 3096496 DOI: 10.1016/0006-8993(86)90171-X |
0.382 |
|
| 1986 |
Sawynok J. Baclofen activates two distinct receptors in the rat spinal cord and guinea pig ileum. Neuropharmacology. 25: 795-8. PMID 3018622 DOI: 10.1016/0028-3908(86)90098-5 |
0.437 |
|
| 1986 |
Sawynok J, Sweeney MI, White TD. Classification of adenosine receptors mediating antinociception in the rat spinal cord. British Journal of Pharmacology. 88: 923-30. PMID 3017496 DOI: 10.1111/J.1476-5381.1986.Tb16267.X |
0.471 |
|
| 1986 |
Sawynok J. The therapeutic use of heroin: a review of the pharmacological literature. Canadian Journal of Physiology and Pharmacology. 64: 1-6. PMID 2420426 DOI: 10.1139/Y86-001 |
0.395 |
|
| 1985 |
Sawynok J, Dickson C. Evidence for the involvement of descending noradrenergic pathways in the antinociceptive effect of baclofen. Brain Research. 335: 89-97. PMID 3924340 DOI: 10.1016/0006-8993(85)90279-3 |
0.454 |
|
| 1985 |
Sawynok J, Dickson C. D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord. Pharmacology. 31: 248-59. PMID 2999839 |
0.319 |
|
| 1985 |
Sawynok J, Robertson G. Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception. Naunyn-Schmiedeberg's Archives of Pharmacology. 331: 152-8. PMID 2418368 DOI: 10.1007/Bf00634232 |
0.445 |
|
| 1985 |
Steardo L, Sawynok J. Clonidine reverses methylxanthine-induced potentiation of baclofen antinociception. Pharmacology, Biochemistry, and Behavior. 22: 905-7. PMID 2409562 DOI: 10.1016/0091-3057(85)90546-5 |
0.41 |
|
| 1984 |
Sawynok J, Moochhala SM, Pillay DJ. Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline. Neuropharmacology. 23: 741-7. PMID 6206433 DOI: 10.1016/0028-3908(84)90106-0 |
0.456 |
|
| 1984 |
Moochhala SM, Sawynok J. Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization. British Journal of Pharmacology. 82: 381-8. PMID 6203593 DOI: 10.1111/J.1476-5381.1984.Tb10773.X |
0.309 |
|
| 1984 |
Sawynok J, Dickson C. D-Baclofen: is it an antagonist at baclofen receptors? Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 729-31. PMID 6099593 DOI: 10.1016/0278-5846(84)90047-2 |
0.323 |
|
| 1984 |
Sawynok J. GABAergic mechanisms in antinociception. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 8: 581-6. PMID 6085175 DOI: 10.1016/0278-5846(84)90018-6 |
0.48 |
|
| 1983 |
Sawynok J. Monoamines as mediators of the antinociceptive effect of baclofen. Naunyn-Schmiedeberg's Archives of Pharmacology. 323: 54-7. PMID 6877393 DOI: 10.1007/BF00498828 |
0.365 |
|
| 1982 |
Sawynok J, Kato N, Havlicek V, LaBella FS. Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro. Naunyn-Schmiedeberg's Archives of Pharmacology. 319: 78-81. PMID 6180329 DOI: 10.1007/BF00491482 |
0.337 |
|
| 1979 |
Sawynok J, Jhamandas K. Interactions of methylxanthines, nonxanthine phosphodiesterase inhibitors, and calcium with morphine in the guinea pig myenteric plexus. Canadian Journal of Physiology and Pharmacology. 57: 853-9. PMID 497898 DOI: 10.1139/Y79-130 |
0.407 |
|
| 1977 |
Sawynok J, Jhamandas K. Muscarinic feedback inhibition of acetylcholine release from the myenteric plexus in the quinea pig ileum and its status after chronic exposure to morphine. Canadian Journal of Physiology and Pharmacology. 55: 909-16. PMID 902164 DOI: 10.1139/Y77-121 |
0.425 |
|
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