Year |
Citation |
Score |
2023 |
Norton EG, Chapman NM, Chi H. Strengthening bonds via RyR2 inhibition helps immune suppression. The Journal of Clinical Investigation. 133. PMID 38099491 DOI: 10.1172/JCI172986 |
0.421 |
|
2023 |
Zhou P, Chi H. Fructose sweetens the adipocyte-T cell alliance against tumors. Cell Metabolism. 35: 2093-2094. PMID 38056424 DOI: 10.1016/j.cmet.2023.11.004 |
0.434 |
|
2023 |
Guo C, Chi H. Immunometabolism of dendritic cells in health and disease. Advances in Immunology. 160: 83-116. PMID 38042587 DOI: 10.1016/bs.ai.2023.10.002 |
0.332 |
|
2023 |
Bell M, Lange S, Sejdiu BI, Ibanez J, Shi H, Sun X, Meng X, Nguyen P, Sutton M, Wagner J, Kc A, Langfitt D, Patil SL, Tan H, Pandey RV, ... ... Chi H, et al. Modular chimeric cytokine receptors with leucine zippers enhance the antitumour activity of CAR T cells via JAK/STAT signalling. Nature Biomedical Engineering. PMID 38036617 DOI: 10.1038/s41551-023-01143-w |
0.464 |
|
2023 |
Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, ... ... Chi H, et al. Trans-vaccenic acid reprograms CD8 T cells and anti-tumour immunity. Nature. PMID 37993715 DOI: 10.1038/s41586-023-06749-3 |
0.342 |
|
2023 |
Zhou P, Shi H, Huang H, Sun X, Yuan S, Chapman NM, Connelly JP, Lim SA, Saravia J, Kc A, Pruett-Miller SM, Chi H. Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer. Nature. PMID 37968405 DOI: 10.1038/s41586-023-06733-x |
0.54 |
|
2023 |
Su W, Saravia J, Risch I, Rankin S, Guy C, Chapman NM, Shi H, Sun Y, Kc A, Li W, Huang H, Lim SA, Hu H, Wang Y, Liu D, ... ... Chi H, et al. CXCR6 orchestrates brain CD8 T cell residency and limits mouse Alzheimer's disease pathology. Nature Immunology. PMID 37679549 DOI: 10.1038/s41590-023-01604-z |
0.468 |
|
2023 |
Reina-Campos M, Heeg M, Kennewick K, Mathews IT, Galletti G, Luna V, Nguyen Q, Huang H, Milner JJ, Hu KH, Vichaidit A, Santillano N, Boland BS, Chang JT, Jain M, ... ... Chi H, et al. Metabolic programs of T cell tissue residency empower tumour immunity. Nature. PMID 37648857 DOI: 10.1038/s41586-023-06483-w |
0.504 |
|
2023 |
Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, Sun X, Saravia J, Rankin S, Dhungana Y, Chi H. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. PMID 37407815 DOI: 10.1038/s41586-023-06299-8 |
0.501 |
|
2023 |
You Z, Chi H. Lipid metabolism in dendritic cell biology. Immunological Reviews. PMID 37172120 DOI: 10.1111/imr.13215 |
0.367 |
|
2023 |
Yu J, Ding L, Shi H, Qian C, Burdyshaw C, Veloso J, Khatamian A, Pan Q, Dhungana Y, Xie Z, Risch I, Yang X, Huang X, Yan L, Rusch M, ... ... Chi H, et al. scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data. Research Square. PMID 36747874 DOI: 10.21203/rs.3.rs-2476875/v1 |
0.331 |
|
2023 |
Ding L, Shi H, Qian C, Burdyshaw C, Veloso JP, Khatamian A, Pan Q, Dhungana Y, Xie Z, Risch I, Yang X, Huang X, Yan L, Rusch M, Brewer M, ... ... Chi H, et al. scMINER: a mutual information-based framework for identifying hidden drivers from single-cell omics data. Biorxiv : the Preprint Server For Biology. PMID 36747870 DOI: 10.1101/2023.01.26.523391 |
0.331 |
|
2023 |
Yuan S, Chi H. Early immune pressure makes tumors metabolically stronger. Cell Metabolism. 35: 3-5. PMID 36599301 DOI: 10.1016/j.cmet.2022.12.009 |
0.312 |
|
2022 |
Blanco DB, Chapman NM, Raynor JL, Xu C, Su W, Kc A, Li W, Lim SA, Schattgen S, Shi H, Risch I, Sun Y, Dhungana Y, Kim Y, Wei J, ... ... Chi H, et al. PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis. Nature Cell Biology. PMID 36302969 DOI: 10.1038/s41556-022-01011-w |
0.541 |
|
2022 |
Guo A, Huang H, Zhu Z, Chen MJ, Shi H, Yuan S, Sharma P, Connelly JP, Liedmann S, Dhungana Y, Li Z, Haydar D, Yang M, Beere H, Yustein JT, ... ... Chi H, et al. cBAF complex components and MYC cooperate early in CD8 T cell fate. Nature. PMID 35732731 DOI: 10.1038/s41586-022-04849-0 |
0.496 |
|
2022 |
Li Y, Yang X, Sun Y, Li Z, Yang W, Ju B, Easton J, Pei D, Cheng C, Lee SH, Pui CH, Yu J, Chi H, Yang JJ. The Impact of T cell Immunity on Chemotherapy Response in Childhood Acute Lymphoblastic Leukemia. Blood. PMID 35675514 DOI: 10.1182/blood.2021014495 |
0.446 |
|
2022 |
Thangavelu G, Andrejeva G, Bolivar-Wagers S, Jin S, Zaiken MC, Loschi M, Aguilar EG, Furlan SN, Brown CC, Lee YC, Hyman CM, Feser CJ, Panoskaltsis-Mortari A, Hippen KL, MacDonald KP, ... ... Chi H, et al. Retinoic acid signaling acts as a rheostat to balance Treg function. Cellular & Molecular Immunology. PMID 35581350 DOI: 10.1038/s41423-022-00869-y |
0.412 |
|
2022 |
Lim SA, Su W, Chapman NM, Chi H. Lipid metabolism in T cell signaling and function. Nature Chemical Biology. 18: 470-481. PMID 35484263 DOI: 10.1038/s41589-022-01017-3 |
0.579 |
|
2022 |
Chi H. Immunometabolism at the intersection of metabolic signaling, cell fate, and systems immunology. Cellular & Molecular Immunology. 19: 299-302. PMID 35190684 DOI: 10.1038/s41423-022-00840-x |
0.359 |
|
2022 |
Chapman NM, Chi H. Metabolic adaptation of lymphocytes in immunity and disease. Immunity. 55: 14-30. PMID 35021054 DOI: 10.1016/j.immuni.2021.12.012 |
0.398 |
|
2021 |
Oh DY, Fong L, Newell EW, Turk MJ, Chi H, Chang HY, Satpathy AT, Fairfax B, Silva-Santos B, Lantz O. Toward a better understanding of T cells in cancer. Cancer Cell. 39: 1549-1552. PMID 34906313 DOI: 10.1016/j.ccell.2021.11.010 |
0.462 |
|
2021 |
Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, ... ... Chi H, et al. CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity. Nature. PMID 34795452 DOI: 10.1038/s41586-021-04109-7 |
0.586 |
|
2021 |
Raynor JL, Chi H. Investigating the Dynamic Changes in iNKT Cell Metabolic Profiles During Development. Methods in Molecular Biology (Clifton, N.J.). 2388: 181-192. PMID 34524673 DOI: 10.1007/978-1-0716-1775-5_17 |
0.366 |
|
2021 |
Shi H, Chi H. Polyamine: A metabolic compass for T helper cell fate direction. Cell. 184: 4109-4112. PMID 34358466 DOI: 10.1016/j.cell.2021.07.012 |
0.39 |
|
2021 |
Fu G, Guy CS, Chapman NM, Palacios G, Wei J, Zhou P, Long L, Wang YD, Qian C, Dhungana Y, Huang H, Kc A, Shi H, Rankin S, Brown SA, ... ... Chi H, et al. Metabolic control of T cells and humoral immunity by phosphatidylethanolamine. Nature. PMID 34234346 DOI: 10.1038/s41586-021-03692-z |
0.57 |
|
2021 |
Gocho Y, Liu J, Hu J, Yang W, Dharia NV, Zhang J, Shi H, Du G, John A, Lin TN, Hunt J, Huang X, Rowland L, Shi L, Maxwell D, ... ... Chi H, et al. Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia. Nature Cancer. 2: 284-299. PMID 34151288 DOI: 10.1038/s43018-020-00167-4 |
0.456 |
|
2021 |
Raynor JL, Chapman NM, Chi H. Metabolic Control of Memory T-Cell Generation and Stemness. Cold Spring Harbor Perspectives in Biology. PMID 33820774 DOI: 10.1101/cshperspect.a037770 |
0.427 |
|
2021 |
Zheng W, Wei J, Zebley C, Jones LL, Dhungana Y, Wang YD, Mavuluri J, Long L, Fan Y, Youngblood B, Chi H, Geiger TL. Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL. Blood. PMID 33690816 DOI: 10.1182/blood.2020009309 |
0.486 |
|
2021 |
Wei J, Zheng W, Chapman NM, Geiger TL, Chi H. T cell metabolism in homeostasis and cancer immunity. Current Opinion in Biotechnology. 68: 240-250. PMID 33676144 DOI: 10.1016/j.copbio.2021.02.003 |
0.537 |
|
2021 |
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, Chapman NM, Fu G, Saravia J, Raynor JL, Liu S, Palacios G, Wang YD, Qian C, Yu J, ... Chi H, et al. In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8 T cell fate decisions. Cell. PMID 33636132 DOI: 10.1016/j.cell.2021.02.021 |
0.523 |
|
2021 |
Lim SA, Wei J, Nguyen TM, Shi H, Su W, Palacios G, Dhungana Y, Chapman NM, Long L, Saravia J, Vogel P, Chi H. Lipid signalling enforces functional specialization of T cells in tumours. Nature. PMID 33627871 DOI: 10.1038/s41586-021-03235-6 |
0.61 |
|
2021 |
Raynor JL, Chi H. LCK senses asparagine for T cell activation. Nature Cell Biology. 23: 7-8. PMID 33420487 DOI: 10.1038/s41556-020-00621-6 |
0.458 |
|
2020 |
Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, Kc A, Vogel P, Chi H. Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T Cells. Cell Metabolism. PMID 33207246 DOI: 10.1016/j.cmet.2020.10.022 |
0.594 |
|
2020 |
Chapman NM, Gottschalk S, Chi H. Preventing Ubiquitination Improves CAR T Cell Therapy via 'CAR Merry-Go-Around'. Immunity. 53: 243-245. PMID 32814023 DOI: 10.1016/j.immuni.2020.07.023 |
0.516 |
|
2020 |
Amersfoort J, Schaftenaar FH, Douna H, van Santbrink PJ, van Puijvelde GHM, Slütter B, Foks AC, Harms A, Moreno-Gordaliza E, Wang Y, Hankemeier T, Bot I, Chi H, Kuiper J. Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells. Cardiovascular Research. PMID 32653923 DOI: 10.1093/Cvr/Cvaa208 |
0.44 |
|
2020 |
Kennedy DE, Okoreeh MK, Maienschein-Cline M, Ai J, Veselits M, McLean KC, Dhungana Y, Wang H, Peng J, Chi H, Mandal M, Clark MR. Novel specialized cell state and spatial compartments within the germinal center. Nature Immunology. PMID 32341509 DOI: 10.1038/S41590-020-0660-2 |
0.32 |
|
2020 |
Raynor JL, Liu C, Dhungana Y, Guy C, Chapman NM, Shi H, Neale G, Sesaki H, Chi H. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions. The Journal of Experimental Medicine. 217. PMID 32289155 DOI: 10.1084/Jem.20191157 |
0.455 |
|
2020 |
Huang H, Long L, Zhou P, Chapman NM, Chi H. mTOR signaling at the crossroads of environmental signals and T-cell fate decisions. Immunological Reviews. PMID 32212344 DOI: 10.1111/imr.12845 |
0.529 |
|
2020 |
Saravia J, Raynor JL, Chapman NM, Lim SA, Chi H. Signaling networks in immunometabolism. Cell Research. PMID 32203134 DOI: 10.1038/s41422-020-0301-1 |
0.511 |
|
2020 |
Yang K, Chi H. Autophagy modulates CD4 T-cell lineage recommitment upon pathogen infection. Cellular & Molecular Immunology. PMID 32047257 DOI: 10.1038/s41423-020-0368-0 |
0.337 |
|
2020 |
Saravia J, Zeng H, Dhungana Y, Bastardo Blanco D, Nguyen TM, Chapman NM, Wang Y, Kanneganti A, Liu S, Raynor JL, Vogel P, Neale G, Carmeliet P, Chi H. Homeostasis and transitional activation of regulatory T cells require c-Myc. Science Advances. 6: eaaw6443. PMID 31911938 DOI: 10.1126/sciadv.aaw6443 |
0.479 |
|
2019 |
Shi H, Chi H. Metabolic Control of Treg Cell Stability, Plasticity, and Tissue-Specific Heterogeneity. Frontiers in Immunology. 10: 2716. PMID 31921097 DOI: 10.3389/fimmu.2019.02716 |
0.476 |
|
2019 |
Wei J, Long L, Zheng W, Dhungana Y, Lim SA, Guy C, Wang Y, Wang YD, Qian C, Xu B, Kc A, Saravia J, Huang H, Yu J, Doench JG, ... ... Chi H, et al. Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy. Nature. PMID 31827283 DOI: 10.1038/S41586-019-1821-Z |
0.468 |
|
2019 |
Du X, Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H. Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress. The Journal of Experimental Medicine. PMID 31722972 DOI: 10.1084/jem.20190969 |
0.505 |
|
2019 |
Shi H, Chapman NM, Wen J, Guy C, Long L, Dhungana Y, Rankin S, Pelletier S, Vogel P, Wang H, Peng J, Guan KL, Chi H. Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb. Immunity. PMID 31668641 DOI: 10.1016/J.Immuni.2019.10.001 |
0.458 |
|
2019 |
Chapman NM, Boothby MR, Chi H. Metabolic coordination of T cell quiescence and activation. Nature Reviews. Immunology. PMID 31406325 DOI: 10.1038/s41577-019-0203-y |
0.57 |
|
2019 |
Zhou P, Chi H. AGK Unleashes CD8 T Cell Glycolysis to Combat Tumor Growth. Cell Metabolism. 30: 233-234. PMID 31390548 DOI: 10.1016/j.cmet.2019.07.008 |
0.431 |
|
2019 |
Wang Y, Du X, Wei J, Long L, Tan H, Guy C, Dhungana Y, Qian C, Neale G, Fu YX, Yu J, Peng J, Chi H. LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity. Cell Research. PMID 30911060 DOI: 10.1038/S41422-019-0157-4 |
0.417 |
|
2019 |
Saravia J, Chapman NM, Chi H. Helper T cell differentiation. Cellular & Molecular Immunology. PMID 30867582 DOI: 10.1038/s41423-019-0220-6 |
0.53 |
|
2018 |
Karmaus PWF, Chen X, Lim SA, Herrada AA, Nguyen TM, Xu B, Dhungana Y, Rankin S, Chen W, Rosencrance C, Yang K, Fan Y, Cheng Y, Easton J, Neale G, ... ... Chi H, et al. Metabolic heterogeneity underlies reciprocal fates of T17 cell stemness and plasticity. Nature. PMID 30568299 DOI: 10.1038/S41586-018-0806-7 |
0.543 |
|
2018 |
Du X, Chapman NM, Chi H. Emerging Roles of Cellular Metabolism in Regulating Dendritic Cell Subsets and Function. Frontiers in Cell and Developmental Biology. 6: 152. PMID 30483503 DOI: 10.3389/fcell.2018.00152 |
0.404 |
|
2018 |
Shi H, Liu C, Tan H, Li Y, Nguyen TM, Dhungana Y, Guy C, Vogel P, Neale G, Rankin S, Feng Y, Peng J, Tao W, Chi H. Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity. Immunity. PMID 30413360 DOI: 10.1016/J.Immuni.2018.10.010 |
0.414 |
|
2018 |
Raynor J, Chi H. Sprouty branches out to control T cell memory. Proceedings of the National Academy of Sciences of the United States of America. PMID 30181286 DOI: 10.1073/pnas.1813460115 |
0.303 |
|
2018 |
McDonald-Hyman C, Muller JT, Loschi M, Thangavelu G, Saha A, Kumari S, Reichenbach DK, Smith MJ, Zhang G, Koehn BH, Lin J, Mitchell JS, Fife BT, Panoskaltsis-Mortari A, Feser CJ, ... ... Chi H, et al. The vimentin intermediate filament network restrains regulatory T-cell suppression of graft-versus-host disease. The Journal of Clinical Investigation. PMID 30106752 DOI: 10.1172/Jci95713 |
0.45 |
|
2018 |
Newton RH, Shrestha S, Sullivan JM, Yates KB, Compeer EB, Ron-Harel N, Blazar BR, Bensinger SJ, Haining WN, Dustin ML, Campbell DJ, Chi H, Turka LA. Maintenance of CD4 T cell fitness through regulation of Foxo1. Nature Immunology. PMID 29988091 DOI: 10.1038/S41590-018-0157-4 |
0.525 |
|
2018 |
Yang K, Blanco DB, Chen X, Dash P, Neale G, Rosencrance C, Easton J, Chen W, Cheng C, Dhungana Y, Kc A, Awad W, Guo XJ, Thomas PG, Chi H. Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells. Science Immunology. 3. PMID 29980617 DOI: 10.1126/sciimmunol.aas9818 |
0.536 |
|
2018 |
Podojil JR, Chiang MY, Ifergan I, Copeland R, Liu LN, Maloveste S, Langermann S, Liebenson D, Balabanov R, Chi H, Chen L, Vignali DAA, Miller SD. B7-H4 Modulates Regulatory CD4 T Cell Induction and Function via Ligation of a Semaphorin 3a/Plexin A4/Neuropilin-1 Complex. Journal of Immunology (Baltimore, Md. : 1950). PMID 29898965 DOI: 10.4049/Jimmunol.1700811 |
0.368 |
|
2018 |
Du X, Wen J, Wang Y, Karmaus PWF, Khatamian A, Tan H, Li Y, Guy C, Nguyen TM, Dhungana Y, Neale G, Peng J, Yu J, Chi H. Hippo/Mst signalling couples metabolic state and immune function of CD8α dendritic cells. Nature. PMID 29849151 DOI: 10.1038/S41586-018-0177-0 |
0.529 |
|
2018 |
Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H. mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T subsets to protect tissue homeostasis. Nature Communications. 9: 2095. PMID 29844370 DOI: 10.1038/S41467-018-04392-5 |
0.53 |
|
2018 |
Chapman NM, Chi H. Hallmarks of T-cell Exit from Quiescence. Cancer Immunology Research. 6: 502-508. PMID 29716982 DOI: 10.1158/2326-6066.CIR-17-0605 |
0.564 |
|
2018 |
Malireddi RKS, Gurung P, Mavuluri J, Dasari TK, Klco JM, Chi H, Kanneganti TD. TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation. The Journal of Experimental Medicine. PMID 29500178 DOI: 10.1084/Jem.20171922 |
0.304 |
|
2018 |
Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, Dhungana Y, Guy C, Neale G, Cloer C, Peng J, Wang D, Chi H. Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. Science Advances. 4: eaar5701. PMID 29399633 DOI: 10.1126/Sciadv.Aar5701 |
0.46 |
|
2018 |
Yang K, Chi H. Investigating Cellular Quiescence of T Lymphocytes and Antigen-Induced Exit from Quiescence. Methods in Molecular Biology (Clifton, N.J.). 1686: 161-172. PMID 29030820 DOI: 10.1007/978-1-4939-7371-2_12 |
0.527 |
|
2017 |
Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D. PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nature Communications. 8: 1457. PMID 29133930 DOI: 10.1038/S41467-017-01388-5 |
0.374 |
|
2017 |
Chapman NM, Shrestha S, Chi H. Metabolism in Immune Cell Differentiation and Function. Advances in Experimental Medicine and Biology. 1011: 1-85. PMID 28875486 DOI: 10.1007/978-94-024-1170-6_1 |
0.358 |
|
2017 |
Yang K, Blanco DB, Neale G, Vogel P, Avila J, Clish CB, Wu C, Shrestha S, Rankin S, Long L, Kc A, Chi H. Homeostatic control of metabolic and functional fitness of Treg cells by LKB1 signalling. Nature. PMID 28847007 DOI: 10.1038/nature23665 |
0.508 |
|
2017 |
Zeng H, Chi H. mTOR signaling in the differentiation and function of regulatory and effector T cells. Current Opinion in Immunology. 46: 103-111. PMID 28535458 DOI: 10.1016/j.coi.2017.04.005 |
0.566 |
|
2017 |
Wei J, Raynor J, Nguyen TM, Chi H. Nutrient and Metabolic Sensing in T Cell Responses. Frontiers in Immunology. 8: 247. PMID 28337199 DOI: 10.3389/fimmu.2017.00247 |
0.543 |
|
2017 |
Tan H, Yang K, Li Y, Shaw TI, Wang Y, Blanco DB, Wang X, Cho JH, Wang H, Rankin S, Guy C, Peng J, Chi H. Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation. Immunity. PMID 28285833 DOI: 10.1016/J.Immuni.2017.02.010 |
0.478 |
|
2017 |
Chapman NM, Chi H. Dietary Fat Inflames CD4(+) T Cell Memory in Obesity. Cell Metabolism. 25: 490-492. PMID 28273470 DOI: 10.1016/j.cmet.2017.02.012 |
0.445 |
|
2016 |
Shi LZ, Saravia J, Zeng H, Kalupahana NS, Guy CS, Neale G, Chi H. Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27994150 DOI: 10.1073/pnas.1617669114 |
0.391 |
|
2016 |
Zeng H, Cohen S, Guy C, Shrestha S, Neale G, Brown SA, Cloer C, Kishton RJ, Gao X, Youngblood B, Do M, Li MO, Locasale JW, Rathmell JC, Chi H. mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation. Immunity. PMID 27637146 DOI: 10.1016/J.Immuni.2016.08.017 |
0.552 |
|
2016 |
Cao G, Wang Q, Li G, Meng Z, Liu H, Tong J, Huang W, Liu Z, Jia Y, Wei J, Chi H, Yang H, Zhao L, Wu Z, Hao J, et al. mTOR inhibition potentiates cytotoxicity of Vγ4 γδ T cells via up-regulating NKG2D and TNF-α. Journal of Leukocyte Biology. PMID 27256566 DOI: 10.1189/jlb.5A0116-053RR |
0.539 |
|
2016 |
Nguyen HD, Chatterjee S, Haarberg KM, Wu Y, Bastian D, Heinrichs J, Fu J, Daenthanasanmak A, Schutt S, Shrestha S, Liu C, Wang H, Chi H, Mehrotra S, Yu XZ. Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation. The Journal of Clinical Investigation. PMID 26950421 DOI: 10.1172/JCI82587 |
0.447 |
|
2016 |
Wei J, Long L, Yang K, Guy C, Shrestha S, Chen Z, Wu C, Vogel P, Neale G, Green DR, Chi H. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nature Immunology. PMID 26808230 DOI: 10.1038/Ni.3365 |
0.509 |
|
2015 |
Li J, Du X, Shi H, Deng K, Chi H, Tao W. Mammalian sterile 20-like kinase 1 (Mst1) enhances the stability of forkhead box P3 (Foxp3) and the Function of Regulatory T cells by Modulating Foxp3 Acetylation. The Journal of Biological Chemistry. PMID 26538561 DOI: 10.1074/jbc.M115.668442 |
0.34 |
|
2015 |
Lukens JR, Gurung P, Shaw PJ, Barr MJ, Zaki MH, Brown SA, Vogel P, Chi H, Kanneganti TD. The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. Immunity. 42: 654-64. PMID 25888258 DOI: 10.1016/J.Immuni.2015.03.006 |
0.485 |
|
2015 |
Huang G, Wang Y, Vogel P, Chi H. Control of IL-17 receptor signaling and tissue inflammation by the p38α-MKP-1 signaling axis in a mouse model of multiple sclerosis. Science Signaling. 8: ra24. PMID 25737586 DOI: 10.1126/scisignal.aaa2147 |
0.441 |
|
2015 |
Liu C, Chapman NM, Karmaus PW, Zeng H, Chi H. mTOR and metabolic regulation of conventional and regulatory T cells. Journal of Leukocyte Biology. PMID 25714803 DOI: 10.1189/Jlb.2Ri0814-408R |
0.569 |
|
2015 |
Yang K, Chi H. AMPK helps T cells survive nutrient starvation. Immunity. 42: 4-6. PMID 25607450 DOI: 10.1016/j.immuni.2014.12.029 |
0.5 |
|
2015 |
Shrestha S, Yang K, Guy C, Vogel P, Neale G, Chi H. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nature Immunology. 16: 178-87. PMID 25559258 DOI: 10.1038/ni.3076 |
0.493 |
|
2015 |
Zeng H, Chi H. Metabolic control of regulatory T cell development and function. Trends in Immunology. 36: 3-12. PMID 25248463 DOI: 10.1016/j.it.2014.08.003 |
0.418 |
|
2014 |
Zeng H, Chi H. mTOR signaling and transcriptional regulation in T lymphocytes. Transcription. 5: e28263. PMID 25764218 DOI: 10.4161/trns.28263 |
0.525 |
|
2014 |
Yang K, Chi H. Metabolic Control of Th17 Cell Generation and CNS Inflammation. Journal of Neurology & Neurophysiology. PMID 25705564 DOI: 10.4172/2155-9562.S12-004 |
0.478 |
|
2014 |
Chapman NM, Chi H. mTOR Links Environmental Signals to T Cell Fate Decisions. Frontiers in Immunology. 5: 686. PMID 25653651 DOI: 10.3389/fimmu.2014.00686 |
0.538 |
|
2014 |
Chapman NM, Chi H. mTOR signaling, Tregs and immune modulation. Immunotherapy. 6: 1295-311. PMID 25524385 DOI: 10.2217/imt.14.84 |
0.451 |
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2014 |
Shrestha S, Yang K, Wei J, Karmaus PW, Neale G, Chi H. Tsc1 promotes the differentiation of memory CD8+ T cells via orchestrating the transcriptional and metabolic programs. Proceedings of the National Academy of Sciences of the United States of America. 111: 14858-63. PMID 25271321 DOI: 10.1073/pnas.1404264111 |
0.512 |
|
2014 |
Wei J, Yang K, Chi H. Cutting edge: Discrete functions of mTOR signaling in invariant NKT cell development and NKT17 fate decision. Journal of Immunology (Baltimore, Md. : 1950). 193: 4297-301. PMID 25261481 DOI: 10.4049/jimmunol.1402042 |
0.447 |
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2014 |
Karmaus PW, Chi H. c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells. Nature Immunology. 15: 828-9. PMID 25137465 DOI: 10.1038/ni.2962 |
0.363 |
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2014 |
Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nature Immunology. 15: 473-81. PMID 24633226 DOI: 10.1038/Ni.2849 |
0.466 |
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2014 |
Wu J, Yang J, Yang K, Wang H, Gorentla B, Shin J, Qiu Y, Que LG, Foster WM, Xia Z, Chi H, Zhong XP. iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions. The Journal of Clinical Investigation. 124: 1685-98. PMID 24614103 DOI: 10.1172/Jci69780 |
0.463 |
|
2014 |
Karmaus PW, Chi H. Genetic dissection of dendritic cell homeostasis and function: lessons from cell type-specific gene ablation. Cellular and Molecular Life Sciences : Cmls. 71: 1893-906. PMID 24366237 DOI: 10.1007/s00018-013-1534-7 |
0.335 |
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2013 |
Zeng H, Chi H. The interplay between regulatory T cells and metabolism in immune regulation. Oncoimmunology. 2: e26586. PMID 24404429 DOI: 10.4161/onci.26586 |
0.415 |
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2013 |
Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF, Chi H. T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity. 39: 1043-56. PMID 24315998 DOI: 10.1016/j.immuni.2013.09.015 |
0.586 |
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2013 |
Wang Y, Huang G, Zeng H, Yang K, Lamb RF, Chi H. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: E4894-903. PMID 24282297 DOI: 10.1073/pnas.1308905110 |
0.435 |
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2013 |
Yang K, Chi H. Tuning mTOR activity for immune balance. The Journal of Clinical Investigation. 123: 5001-4. PMID 24270416 DOI: 10.1172/JCI73202 |
0.568 |
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2013 |
Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, ... ... Chi H, et al. Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Proceedings of the National Academy of Sciences of the United States of America. 110: 19884-9. PMID 24248350 DOI: 10.1073/Pnas.1320145110 |
0.34 |
|
2013 |
Shi LZ, Chi H. Gfi1: a unique controller of T(reg) cells. Cell Cycle (Georgetown, Tex.). 12: 3581-2. PMID 24131921 DOI: 10.4161/cc.26824 |
0.415 |
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2013 |
Shi LZ, Kalupahana NS, Turnis ME, Neale G, Hock H, Vignali DA, Chi H. Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 110: E3198-205. PMID 23918371 DOI: 10.1073/Pnas.1300950110 |
0.564 |
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2013 |
Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature. 499: 485-90. PMID 23812589 DOI: 10.1038/nature12297 |
0.612 |
|
2013 |
Huang G, Wang Y, Chi H. Control of T cell fates and immune tolerance by p38α signaling in mucosal CD103+ dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 191: 650-9. PMID 23752611 DOI: 10.4049/jimmunol.1300398 |
0.456 |
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2013 |
Zeng H, Chi H. mTOR and lymphocyte metabolism. Current Opinion in Immunology. 25: 347-55. PMID 23722114 DOI: 10.1016/j.coi.2013.05.002 |
0.488 |
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2013 |
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. The Embo Journal. 32: 816-28. PMID 23422957 DOI: 10.1038/emboj.2013.28 |
0.424 |
|
2012 |
Yang K, Chi H. mTOR and metabolic pathways in T cell quiescence and functional activation. Seminars in Immunology. 24: 421-8. PMID 23375549 DOI: 10.1016/j.smim.2012.12.004 |
0.596 |
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2012 |
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration Immunity. 37: 971-985. PMID 23159437 DOI: 10.1016/J.Immuni.2012.10.007 |
0.359 |
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2012 |
Chi H. Regulation and function of mTOR signalling in T cell fate decisions. Nature Reviews. Immunology. 12: 325-38. PMID 22517423 DOI: 10.1038/nri3198 |
0.582 |
|
2012 |
Huang G, Wang Y, Chi H. Regulation of TH17 cell differentiation by innate immune signals. Cellular & Molecular Immunology. 9: 287-95. PMID 22504954 DOI: 10.1038/cmi.2012.10 |
0.558 |
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2012 |
Lukens JR, Barr MJ, Chaplin DD, Chi H, Kanneganti TD. Inflammasome-derived IL-1β regulates the production of GM-CSF by CD4(+) T cells and γδ T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 3107-15. PMID 22345669 DOI: 10.4049/Jimmunol.1103308 |
0.389 |
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2012 |
Wang Y, Huang G, Vogel P, Neale G, Reizis B, Chi H. Transforming growth factor beta-activated kinase 1 (TAK1)-dependent checkpoint in the survival of dendritic cells promotes immune homeostasis and function. Proceedings of the National Academy of Sciences of the United States of America. 109: E343-52. PMID 22308391 DOI: 10.1073/Pnas.1115635109 |
0.391 |
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2012 |
Huang G, Wang Y, Vogel P, Kanneganti TD, Otsu K, Chi H. Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation. Nature Immunology. 13: 152-61. PMID 22231518 DOI: 10.1038/ni.2207 |
0.508 |
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2011 |
Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 35: 871-82. PMID 22195744 DOI: 10.1016/J.Immuni.2011.09.021 |
0.477 |
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2011 |
Yang K, Neale G, Green DR, He W, Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nature Immunology. 12: 888-97. PMID 21765414 DOI: 10.1038/Ni.2068 |
0.433 |
|
2011 |
Huang G, Wang Y, Shi LZ, Kanneganti TD, Chi H. Signaling by the phosphatase MKP-1 in dendritic cells imprints distinct effector and regulatory T cell fates. Immunity. 35: 45-58. PMID 21723158 DOI: 10.1016/j.immuni.2011.05.014 |
0.571 |
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2011 |
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. The Journal of Experimental Medicine. 208: 1367-76. PMID 21708926 DOI: 10.1084/Jem.20110278 |
0.516 |
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2011 |
Shaw PJ, Barr MJ, Lukens JR, McGargill MA, Chi H, Mak TW, Kanneganti TD. Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity. 34: 75-84. PMID 21236705 DOI: 10.1016/J.Immuni.2010.12.015 |
0.318 |
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2010 |
Liu G, Yang K, Burns S, Shrestha S, Chi H. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nature Immunology. 11: 1047-56. PMID 20852647 DOI: 10.1038/ni.1939 |
0.504 |
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2010 |
Chi H, Flavell RA. Studies on MAP Kinase signaling in the immune system. Methods in Molecular Biology (Clifton, N.J.). 661: 471-80. PMID 20812002 DOI: 10.1007/978-1-60761-795-2_29 |
0.487 |
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2010 |
He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. Journal of Immunology (Baltimore, Md. : 1950). 185: 126-33. PMID 20525896 DOI: 10.4049/Jimmunol.0903767 |
0.502 |
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2010 |
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 184: 4610-4. PMID 20368281 DOI: 10.4049/Jimmunol.1000217 |
0.305 |
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2009 |
Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. Plos Biology. 7: e1000196. PMID 19753101 DOI: 10.1371/Journal.Pbio.1000196 |
0.31 |
|
2009 |
Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H. The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nature Immunology. 10: 769-77. PMID 19483717 DOI: 10.1038/Ni.1743 |
0.526 |
|
2007 |
Menon S, Chi H, Zhang H, Deng XW, Flavell RA, Wei N. COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence. Nature Immunology. 8: 1236-45. PMID 17906629 DOI: 10.1038/Ni1514 |
0.499 |
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2007 |
Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2730-6. PMID 17312115 DOI: 10.4049/Jimmunol.178.5.2730 |
0.467 |
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2006 |
Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nature Immunology. 7: 851-8. PMID 16799562 DOI: 10.1038/Ni1355 |
0.528 |
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2005 |
Gao Y, Tao J, Li MO, Zhang D, Chi H, Henegariu O, Kaech SM, Davis RJ, Flavell RA, Yin Z. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. Journal of Immunology (Baltimore, Md. : 1950). 175: 5783-9. PMID 16237070 DOI: 10.4049/Jimmunol.175.9.5783 |
0.42 |
|
2005 |
Chi H, Flavell RA. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. Journal of Immunology (Baltimore, Md. : 1950). 174: 2485-8. PMID 15728452 DOI: 10.4049/Jimmunol.174.5.2485 |
0.458 |
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2004 |
Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. The Embo Journal. 23: 1576-86. PMID 15044949 DOI: 10.1038/Sj.Emboj.7600173 |
0.487 |
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