Patrick Weinkam, Ph.D.

Chemistry University of California, San Diego, La Jolla, CA 
protein folding, regulatory networks, glasses, many-body phenomena
"Patrick Weinkam"


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Peter G. Wolynes grad student 2009 UCSD
 (The folding energy landscape of cytochrome c: Theoretical and experimental investigations.)
Floyd E. Romesberg grad student 2004-2009 Scripps Institute (Chemistry Tree)
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Cimermancic P, Weinkam P, Rettenmaier TJ, et al. (2016) CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites. Journal of Molecular Biology
Pieper U, Webb BM, Dong GQ, et al. (2014) ModBase, a database of annotated comparative protein structure models and associated resources. Nucleic Acids Research. 42: D336-46
Weinkam P, Sali A. (2013) Mapping polymerization and allostery of hemoglobin S using point mutations. The Journal of Physical Chemistry. B. 117: 13058-68
Guttman M, Weinkam P, Sali A, et al. (2013) All-atom ensemble modeling to analyze small-angle x-ray scattering of glycosylated proteins. Structure (London, England : 1993). 21: 321-31
Weinkam P, Chen YC, Pons J, et al. (2013) Impact of mutations on the allosteric conformational equilibrium. Journal of Molecular Biology. 425: 647-61
Weinkam P, Pons J, Sali A. (2012) Structure-based model of allostery predicts coupling between distant sites. Proceedings of the National Academy of Sciences of the United States of America. 109: 4875-80
Craig PO, Lätzer J, Weinkam P, et al. (2011) Prediction of native-state hydrogen exchange from perfectly funneled energy landscapes. Journal of the American Chemical Society. 133: 17463-72
Weinkam P, Zimmermann J, Romesberg FE, et al. (2010) The folding energy landscape and free energy excitations of cytochrome c. Accounts of Chemical Research. 43: 652-60
Weinkam P, Romesberg FE, Wolynes PG. (2009) Chemical frustration in the protein folding landscape: grand canonical ensemble simulations of cytochrome c. Biochemistry. 48: 2394-402
Weinkam P, Pletneva EV, Gray HB, et al. (2009) Electrostatic effects on funneled landscapes and structural diversity in denatured protein ensembles. Proceedings of the National Academy of Sciences of the United States of America. 106: 1796-801
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