Brendan D. Manning, Ph.D.

Affiliations: 
2000 Yale University, New Haven, CT 
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"Brendan Manning"

Parents

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Michael Snyder grad student 2000 Yale
 (The genetic, cytological, and biochemical analyses of Cik1p and Vik1p, two regulators of a multifunctional kinesin.)

Children

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Issam Ben-Sahra post-doc (Neurotree)
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Publications

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Manning BD, Dibble CC. (2024) Growth Signaling Networks Orchestrate Cancer Metabolic Networks. Cold Spring Harbor Perspectives in Medicine
Hosios AM, Wilkinson ME, McNamara MC, et al. (2022) mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nature Metabolism. 4: 1792-1811
Soflaee MH, Kesavan R, Sahu U, et al. (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 13: 2698
Hosios AM, Manning BD. (2021) Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect. Cancer Research. 81: 4896-4898
Byles V, Cormerais Y, Kalafut K, et al. (2021) Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Molecular Metabolism. 101309
Torrence ME, MacArthur MR, Hosios AM, et al. (2021) The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 10
Valvezan AJ, McNamara MC, Miller SK, et al. (2020) IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. Jci Insight. 5
Valvezan AJ, Manning BD. (2019) Molecular logic of mTORC1 signalling as a metabolic rheostat. Nature Metabolism. 1: 321-333
Hoxhaj G, Manning BD. (2019) The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nature Reviews. Cancer
Brown FD, Sen DR, LaFleur MW, et al. (2019) Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nature Immunology
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