|1986-||Genetics||Harvard University, Cambridge, MA, United States|
Dr. Perrimon has 30 years of experience in the fields of developmental genetics, signal transduction and genomics. By developing, improving, and applying a number of genetic techniques (germline clones, FLP/FRT, Gal4/UAS, etc.), his group identified many key components of the Receptor Tyrosine Kinases, JAK/STAT, Wnt, Hedgehog and Notch signaling pathways. In recent years, his group established high-throughput genome-wide RNAi screens to systematically interrogate the entire Drosophila genome in various cell-based assays. In 2003 he created the Drosophila RNAi Screening Center at Harvard Medical School to make this technology available to the community. In addition, in 2008, he initiated the Transgenic RNAi Project to generate transgenic RNAi lines for the community using optimized shRNA vectors that his lab developed. Currently, his laboratory is applying large-scale RNAi and proteomic methods to obtain a global understanding to the structure of a number of signaling pathways and their crosstalks. In addition, he is studying the roles of signaling pathways in homeostasis and tissue remodeling in Drosophila muscles and gut stem cells. Dr. Perrimon has trained more than 80 students and postdoctoral fellows, most of whom currently hold academic positions.
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|Droujinine IA, Meyer AS, Wang D, et al. (2021) Proteomics of protein trafficking by in vivo tissue-specific labeling. Nature Communications. 12: 2382|
|Cho S, Lee G, Pickering BF, et al. (2021) mTORC1 promotes cell growth via mA-dependent mRNA degradation. Molecular Cell|
|Mohr SE, Tattikota SG, Xu J, et al. (2021) Methods and tools for spatial mapping of single-cell RNAseq clusters in Drosophila. Genetics|
|Tang HW, Weng JH, Lee WX, et al. (2021) mTORC1-chaperonin CCT signaling regulates mA RNA methylation to suppress autophagy. Proceedings of the National Academy of Sciences of the United States of America. 118|
|Parkhitko AA, Singh A, Hsieh S, et al. (2021) Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. Plos Genetics. 17: e1009354|
|Ghosh AC, Tattikota SG, Liu Y, et al. (2021) Correction: PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Elife. 10|
|Wang W, Li J, Tan J, et al. (2021) Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nature Communications. 12: 476|
|Bosch JA, Birchak G, Perrimon N. (2021) Precise genome engineering in using prime editing. Proceedings of the National Academy of Sciences of the United States of America. 118|
|Ghosh AC, Tattikota SG, Liu Y, et al. (2020) PDGF/VEGF signaling from muscles to hepatocyte-like cells protects against obesity. Elife. 9|
|Hu Y, Comjean A, Rodiger J, et al. (2020) FlyRNAi.org-the database of the Drosophila RNAi screening center and transgenic RNAi project: 2021 update. Nucleic Acids Research|