Robert K. Bradley

Affiliations: 
2009-2011 Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
 2011- Computational Biology Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
Website:
http://bradleybiology.org/
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"Robert Bradley"

Parents

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Ian Holmes grad student 2008 UC Berkeley
 (Annotation, alignment and reconstruction of non-coding RNA.)
Michael B. Eisen post-doc 2008-2009 HHMI, University of California-Berkeley (FlyTree)
Christopher B. Burge post-doc 2009-2011 MIT
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Publications

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North K, Benbarche S, Liu B, et al. (2022) Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nature Biotechnology
Clough CA, Pangallo J, Sarchi M, et al. (2021) Coordinated mis-splicing of TMEM14C and ABCB7 causes ring sideroblast formation in SF3B1-mutant myelodysplastic syndrome. Blood
Beauchamp EM, Leventhal M, Bernard E, et al. (2021) is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing. Blood Cancer Discovery. 2: 500-517
Lu SX, De Neef E, Thomas JD, et al. (2021) Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell
Inoue D, Polaski JT, Taylor J, et al. (2021) Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nature Genetics
Chew GL, Bleakley M, Bradley RK, et al. (2021) Short H2A histone variants are expressed in cancer. Nature Communications. 12: 490
Polaski JT, Udy DB, Escobar-Hoyos LF, et al. (2021) The origins and consequences of variants in pancreatic adenosquamous carcinoma. Elife. 10
Taylor J, Mi X, North KD, et al. (2020) Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms. Blood
Escobar-Hoyos LF, Penson A, Kannan R, et al. (2020) Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Cancer Cell
Jones TI, Chew GL, Barraza-Flores P, et al. (2020) Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity. Skeletal Muscle. 10: 8
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