Gerard Manning

Affiliations: 
1989-1997 Biochemistry Stanford University, Palo Alto, CA 
 2004-2012 Salk Institute for Biological Studies, La Jolla, CA, United States 
 2012- Bioinformatics & Computational Biology Genentech, Inc., San Francisco, CA, United States 
Area:
Bioinformatics, Genomics, Oncology, Evolution
Website:
http://manninglab.org
Google:
"Gerard Manning"
Bio:

Developed the Drosophila tracheal system as a model for branching morphogenesis, during my PhD with Mark Krasnow at Stanford. Now working on evolutionary genomics, with a focus on protein kinases and still a soft spot for Drosophila and insect evo-devo, and on analysis of large-scale tumor mutation data

Cross-listing: FlyTree

Parents

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Mark Krasnow grad student 1989-1997 (FlyTree)

Collaborators

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Tony Hunter collaborator 2002- Salk Institute (DevTree)
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Publications

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Rinaldi J, Sokol ES, Hartmaier RJ, et al. (2020) The genomic landscape of metastatic breast cancer: Insights from 11,000 tumors. Plos One. 15: e0231999
Petrie EJ, Sandow JJ, Lehmann WIL, et al. (2019) Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3. Cell Reports. 28: 3309-3319.e5
Daemen A, Manning G. (2018) HER2 is not a cancer subtype but rather a pan-cancer event and is highly enriched in AR-driven breast tumors. Breast Cancer Research : Bcr. 20: 8
Manning G, Lounsbury N, Hartmaier R, et al. (2018) Abstract PR03: Dissecting the playbook of cancer: Genomic analysis of 100,000 human tumors reveals elaborate patterns of activation of the RTK-RAS-MAPK pathway Clinical Cancer Research. 24
Chen MJ, Dixon JE, Manning G. (2017) Genomics and evolution of protein phosphatases. Science Signaling. 10
Foster SA, Whalen DM, Özen A, et al. (2016) Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2. Cancer Cell
Newton K, Manning G. (2016) Necroptosis and Inflammation. Annual Review of Biochemistry
Daemen A, Rinaldi J, Manning G. (2016) Abstract B53: Genomic redefinition of Her2+ breast shows role of estrogen and androgen signaling Molecular Cancer Research. 14
Foster S, Whalen D, Ozen A, et al. (2016) Abstract 4374: Activation mechanism of oncogenic C-helix shifting mutations in BRAF, EGFR, and HER2 Cancer Research. 76: 4374-4374
Brown N, Finnon R, Manning G, et al. (2015) Influence of radiation quality on mouse chromosome 2 deletions in radiation-induced acute myeloid leukaemia. Mutation Research. Genetic Toxicology and Environmental Mutagenesis. 793: 48-54
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