David A. Orlando, Ph.D.

Affiliations: 
2009 Computational Biology and Bioinformatics Duke University, Durham, NC 
Area:
Bioinformatics, Genetics
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"David Orlando"

Parents

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Steven B. Haase grad student Duke University/ Department of Biology (Physics Tree)
Philip N. Benfey grad student 2009 (Plant Biology Tree)
 (Regulation of global transcription dynamics during cell division and root development)
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Publications

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Campione SA, Kelliher CM, Orlando DA, et al. (2023) Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons. Journal of Visualized Experiments : Jove
Hu S, Marineau JJ, Rajagopal N, et al. (2019) Discovery and characterization of SY-1365, a selective, covalent inhibitor of CDK7. Cancer Research
Hu S, Marineau J, Hamman K, et al. (2019) Abstract 4421: SY-5609, an orally available selective CDK7 inhibitor demonstrates broad anti-tumor activity in vivo Cancer Research. 79: 4421-4421
Ke N, Johannessen L, Rajagopal N, et al. (2019) Abstract 4409: Prospective identification of RB pathway alterations predict response to SY-1365, a selective CDK7 inhibitor, in a panel of high-grade serous ovarian cancer (HGSOC) patient derived xenograft (PDX) models Cancer Research. 79: 4409-4409
Guenther M, Lambert A, Chen M, et al. (2018) Abstract P2-04-03: Epigenomic analysis of cancer stem cell (CSC)-enriched triple-negative breast cancer (TNBC) populations reveals gene regulatory circuitry and novel tumor cell vulnerabilities Cancer Research. 78
Rajagopal N, Hodgson G, Hu S, et al. (2018) Abstract P1-09-08:BCL2L1(BCL-XL) expression and MYC super-enhancer positivity predict sensitivity to the covalent CDK7 inhibitor SY-1365 in triple negative breast cancer (TNBC) cell lines Cancer Research. 78
Konstantinopoulos PA, Hodgson G, Rajagopal N, et al. (2018) Abstract 1525: SY-1365, a selective CDK7 inhibitor, exhibits potent antitumor activity against ovarian cancer models in vitro and in vivo Cancer Research. 78: 1525-1525
McKeown MR, Corces MR, Eaton ML, et al. (2017) Super-Enhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist. Cancer Discovery
Hu S, Ke N, Ren Y, et al. (2017) Abstract 1151: SY-1365, a potent and selective CDK7 inhibitor, exhibits promising anti-tumor activity in multiple preclinical models of aggressive solid tumors Cancer Research. 77: 1151-1151
Bradley M, Marineau J, Choi Y, et al. (2017) Abstract 1143: Targeting the transcriptional kinases CDK12 and CDK13 in breast and ovarian cancer Cancer Research. 77: 1143-1143
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