Xuebing Wu, Ph.D.
Affiliations: | 2010-2014 | Koch Institute | Massachusetts Institute of Technology, Cambridge, MA, United States |
| 2014-2018 | David Bartel Lab | Whitehead Institute for Biomedical Research (MIT) | |
| 2018- | Medicine; Systems Biology | Columbia University, New York, NY |
Area:
RNAWebsite:
https://xuebingwu.github.io/Google:
"Xuebing Wu"Bio:
Xuebing Wu, PhD, joined Columbia University as an assistant professor in November, 2018. Dr. Wu received his BS and MS in Control Science and Engineering from Tsinghua University, Beijing. He pursued his PhD in Computational and Systems Biology at MIT with Phillip Sharp and Christopher Burge. He worked as an Helen Hay Whitney Fellow in Dr. David Bartel’s lab at Whitehead Institute/MIT prior to joining Columbia. The Wu lab integrates CRISPR, genomics, and machine learning to both decode and target RNA in human health and disease. The Wu lab seeks to bridge the discovery of basic mechanisms of gene regulation with the development of novel therapeutics for human diseases, focusing on cancer and cardiometabolic diseases.
Parents
Sign in to add mentor| Rui Jiang | grad student | 2007-2009 | Tsinghua University (Beijing) |
| Christopher B. Burge | grad student | 2010-2014 | MIT |
| Phillip Allen Sharp | grad student | 2010-2014 | MIT (Chemistry Tree) |
| David P. Bartel | post-doc | 2014-2018 | MIT (Chemistry Tree) |
Children
Sign in to add trainee| Ziheng Chen | grad student | 2019- | Columbia |
| Michael Robert Murphy | post-doc | Columbia (Chemistry Tree) |
Collaborators
Sign in to add collaborator| Feng Zhang | collaborator | 2014-2015 | Broad Institute of Harvard and MIT (Neurotree) |
Publications
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| Kesner JS, Wu X. (2024) Mechanisms suppressing noncoding translation. Trends in Cell Biology |
| Zhang Y, Zhang W, Zhao J, et al. (2023) mA RNA modification regulates innate lymphoid cell responses in a lineage-specific manner. Nature Immunology |
| Kesner JS, Chen Z, Shi P, et al. (2023) Noncoding translation mitigation. Nature |
| Shi P, Murphy MR, Aparicio AO, et al. (2023) Collateral activity of the CRISPR/RfxCas13d system in human cells. Communications Biology. 6: 334 |
| Zhang C, Konermann S, Brideau NJ, et al. (2018) Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d. Cell. 175: 212-223.e17 |
| Tycko J, Barrera LA, Huston NC, et al. (2018) Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. Nature Communications. 9: 2962 |
| Jiang W, Wei Y, Long Y, et al. (2018) A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in . Elife. 7 |
| Liu XS, Wu H, Krzisch M, et al. (2018) Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell |
| Chiu AC, Suzuki HI, Wu X, et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molecular Cell |
| Wu X, Bartel DP. (2017) Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Cell. 169: 905-917.e11 |