Xuebing Wu, Ph.D.

2010-2014 Koch Institute Massachusetts Institute of Technology, Cambridge, MA, United States 
 2014-2018 David Bartel Lab Whitehead Institute for Biomedical Research (MIT) 
 2018- Medicine; Systems Biology Columbia University, New York, NY 
"Xuebing Wu"

Xuebing Wu, PhD, joined Columbia University as an assistant professor in November, 2018. Dr. Wu received his BS and MS in Control Science and Engineering from Tsinghua University, Beijing. He pursued his PhD in Computational and Systems Biology at MIT with Phillip Sharp and Christopher Burge. He worked as an Helen Hay Whitney Fellow in Dr. David Bartel’s lab at Whitehead Institute/MIT prior to joining Columbia. The Wu lab integrates CRISPR, genomics, and machine learning to both decode and target RNA in human health and disease. The Wu lab seeks to bridge the discovery of basic mechanisms of gene regulation with the development of novel therapeutics for human diseases, focusing on cancer and cardiometabolic diseases.


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Rui Jiang grad student 2007-2009 Tsinghua University (Beijing)
Christopher B. Burge grad student 2010-2014 MIT
Phillip Allen Sharp grad student 2010-2014 MIT (Chemistry Tree)
David P. Bartel post-doc 2014-2018 MIT (Chemistry Tree)


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Ziheng Chen grad student 2019- Columbia
Michael Robert Murphy post-doc Columbia (Chemistry Tree)


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Feng Zhang collaborator 2014-2015 Broad Institute of Harvard and MIT (Neurotree)
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Zhang Y, Zhang W, Zhao J, et al. (2023) mA RNA modification regulates innate lymphoid cell responses in a lineage-specific manner. Nature Immunology
Kesner JS, Chen Z, Shi P, et al. (2023) Noncoding translation mitigation. Nature
Shi P, Murphy MR, Aparicio AO, et al. (2023) Collateral activity of the CRISPR/RfxCas13d system in human cells. Communications Biology. 6: 334
Zhang C, Konermann S, Brideau NJ, et al. (2018) Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d. Cell. 175: 212-223.e17
Tycko J, Barrera LA, Huston NC, et al. (2018) Pairwise library screen systematically interrogates Staphylococcus aureus Cas9 specificity in human cells. Nature Communications. 9: 2962
Jiang W, Wei Y, Long Y, et al. (2018) A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in . Elife. 7
Liu XS, Wu H, Krzisch M, et al. (2018) Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene. Cell
Chiu AC, Suzuki HI, Wu X, et al. (2018) Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molecular Cell
Wu X, Bartel DP. (2017) Widespread Influence of 3'-End Structures on Mammalian mRNA Processing and Stability. Cell. 169: 905-917.e11
Wu X, Bartel DP. (2017) kpLogo: positional k-mer analysis reveals hidden specificity in biological sequences. Nucleic Acids Research
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