Sara M. Weis, Ph.D.

Affiliations: 
2000 University of California, San Diego, La Jolla, CA 
Area:
Biomedical Engineering
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"Sara Weis"

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Andrew D. McCulloch grad student 2000 UCSD
 (Effects of collagen dysregulation on structure and mechanics of normal and post -infarction myocardium.)
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Publications

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Franovic A, Elliott KC, Seguin L, et al. (2015) Glioblastomas Require Integrin αvβ3/PAK4 Signaling to Escape Senescence. Cancer Research. 75: 4466-73
Seguin L, Desgrosellier JS, Weis SM, et al. (2015) Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance. Trends in Cell Biology. 25: 234-40
Advani SJ, Camargo MF, Seguin L, et al. (2015) Kinase-independent role for CRAF-driving tumour radioresistance via CHK2 Nature Communications. 6
Seguin L, Gozo M, Weis SM, et al. (2014) Targeting the Achilles' heel of drug-resistant cancer stem cells. Cell Cycle (Georgetown, Tex.). 13: 2017-8
Seguin L, Weis SM, Cheresh DA. (2014) Variety in the tumor microenvironment: integrin splicing regulates stemness. Cell Stem Cell. 14: 557-8
Seguin L, Kato S, Franovic A, et al. (2014) An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nature Cell Biology. 16: 457-68
Jean C, Chen XL, Nam JO, et al. (2014) Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. The Journal of Cell Biology. 204: 247-63
Weis SM, Cheresh DA. (2013) A wake-up call for hibernating tumour cells. Nature Cell Biology. 15: 721-3
Lim ST, Miller NL, Chen XL, et al. (2012) Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression. The Journal of Cell Biology. 197: 907-19
Lau SK, Shields DJ, Murphy EA, et al. (2012) EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1. Plos One. 7: e36753
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