Amanda C. Poholek, Ph.D.
Affiliations: | 2009 | Yale University, New Haven, CT |
Area:
ImmunologyGoogle:
"Amanda Poholek"Parents
Sign in to add mentorJoseph Craft | grad student | 2009 | Yale | |
(Key factors in T follicular helper cell development.) |
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Publications
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Ford BR, Poholek AC. (2023) Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses. Journal of Immunology (Baltimore, Md. : 1950). 210: 869-879 |
Vignali PDA, DePeaux K, Watson MJ, et al. (2022) Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nature Immunology |
Ford BR, Vignali PDA, Rittenhouse NL, et al. (2022) Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Science Immunology. 7: eabj9123 |
Dwyer GK, Mathews LR, Villegas JA, et al. (2022) IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease. The Journal of Clinical Investigation |
Poholek AC. (2022) CAR T cells are in it [CD]4 the long haul. Cell. 185: 1112-1114 |
Poholek AC. (2021) Tissue-Specific Contributions to Control of T Cell Immunity. Immunohorizons. 5: 410-423 |
Watson MJ, Vignali PDA, Mullett SJ, et al. (2021) Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature |
Scharping NE, Rivadeneira DB, Menk AV, et al. (2021) Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature Immunology |
Poholek CH, Raphael I, Wu D, et al. (2020) Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen. The Journal of Experimental Medicine. 217 |
He K, Hettinga A, Kale SL, et al. (2020) Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung. The Journal of Experimental Medicine. 217 |