Amanda C. Poholek, Ph.D.

Affiliations: 
2009 Yale University, New Haven, CT 
Area:
Immunology
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"Amanda Poholek"

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Joseph Craft grad student 2009 Yale
 (Key factors in T follicular helper cell development.)
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Publications

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Ford BR, Poholek AC. (2023) Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses. Journal of Immunology (Baltimore, Md. : 1950). 210: 869-879
Vignali PDA, DePeaux K, Watson MJ, et al. (2022) Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity. Nature Immunology
Ford BR, Vignali PDA, Rittenhouse NL, et al. (2022) Tumor microenvironmental signals reshape chromatin landscapes to limit the functional potential of exhausted T cells. Science Immunology. 7: eabj9123
Dwyer GK, Mathews LR, Villegas JA, et al. (2022) IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease. The Journal of Clinical Investigation
Poholek AC. (2022) CAR T cells are in it [CD]4 the long haul. Cell. 185: 1112-1114
Poholek AC. (2021) Tissue-Specific Contributions to Control of T Cell Immunity. Immunohorizons. 5: 410-423
Watson MJ, Vignali PDA, Mullett SJ, et al. (2021) Metabolic support of tumour-infiltrating regulatory T cells by lactic acid. Nature
Scharping NE, Rivadeneira DB, Menk AV, et al. (2021) Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nature Immunology
Poholek CH, Raphael I, Wu D, et al. (2020) Noncanonical STAT3 activity sustains pathogenic Th17 proliferation and cytokine response to antigen. The Journal of Experimental Medicine. 217
He K, Hettinga A, Kale SL, et al. (2020) Blimp-1 is essential for allergen-induced asthma and Th2 cell development in the lung. The Journal of Experimental Medicine. 217
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