Tsuyoshi Hirashima

2017-2022 Medical School Kyoto University, Kyōto-shi, Kyōto-fu, Japan 
 2022- Institute of Mechanobiology National University of Singapore, Singapore, Singapore 
Mathematical Biology, Morphogenesis, Imaging, mechanobiology
"Tsuyoshi Hirashima"


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Yoh Iwasa grad student 2006-2011 Kyushu University
 (mathematical biology of morphogenesis, mathematics for development)
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Hirashima T, Matsuda M. (2024) ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue. Current Biology : Cb. 34: 683-696.e6
Nayak AN, Hirashima T. (2023) Tug-of-war via ERK signaling pathway for tissue organization - ERK activation to force generation. Current Opinion in Cell Biology. 85: 102249
Hino N, Matsuda K, Jikko Y, et al. (2022) A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration. Developmental Cell
Hirashima T. (2022) Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development. The Biochemical Journal. 479: 129-143
Ishii M, Tateya T, Matsuda M, et al. (2021) Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea. Royal Society Open Science. 8: 211024
Hino N, Rossetti L, Marín-Llauradó A, et al. (2020) ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization. Developmental Cell. 53: 646-660.e8
Okabe R, Chen-Yoshikawa TF, Yoshizawa A, et al. (2020) Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice. European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association For Cardio-Thoracic Surgery
Tateya T, Sakamoto S, Ishidate F, et al. (2019) Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea. Development (Cambridge, England). 146
Hirashima T, Adachi T. (2019) Polarized cellular mechanoresponse system for maintaining radial size in developing epithelial tubes. Development (Cambridge, England)
Ihermann-Hella A, Hirashima T, Kupari J, et al. (2018) Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation. Stem Cell Reports
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