David Heckmann

Affiliations: 
2019 University of California, San Diego, La Jolla, CA 
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"David Heckmann"
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Sastry AV, Hu A, Heckmann D, et al. (2021) Independent component analysis recovers consistent regulatory signals from disparate datasets. Plos Computational Biology. 17: e1008647
Heckmann D, Campeau A, Lloyd CJ, et al. (2020) Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers. Proceedings of the National Academy of Sciences of the United States of America
Phaneuf PV, Yurkovich JT, Heckmann D, et al. (2020) Causal mutations from adaptive laboratory evolution are outlined by multiple scales of genome annotations and condition-specificity. Bmc Genomics. 21: 514
Kavvas ES, Yang L, Monk JM, et al. (2020) A biochemically-interpretable machine learning classifier for microbial GWAS. Nature Communications. 11: 2580
Mih N, Monk JM, Fang X, et al. (2020) Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes. Bmc Bioinformatics. 21: 162
Yang L, Mih N, Anand A, et al. (2019) Cellular responses to reactive oxygen species are predicted from molecular mechanisms. Proceedings of the National Academy of Sciences of the United States of America
Heckmann D, Zielinski DC, Palsson BO. (2018) Modeling genome-wide enzyme evolution predicts strong epistasis underlying catalytic turnover rates. Nature Communications. 9: 5270
Heckmann D, Lloyd CJ, Mih N, et al. (2018) Machine learning applied to enzyme turnover numbers reveals protein structural correlates and improves metabolic models. Nature Communications. 9: 5252
Kavvas ES, Catoiu E, Mih N, et al. (2018) Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. Nature Communications. 9: 4306
Kleinmanns JA, Schatlowski N, Heckmann D, et al. (2017) BLISTER Regulates Polycomb-Target Genes, Represses Stress-Regulated Genes and Promotes Stress Responses in . Frontiers in Plant Science. 8: 1530
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