Marko Hyvonen

Affiliations: 
University of Cambridge, Cambridge, England, United Kingdom 
Area:
Structural biology, biophysics, biochemistry, fragment-based drug discovery
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"Marko Hyvonen"

Children

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Adrian Harrington grad student 2002-2006 Cambridge
Ye Gu grad student 2008-2012 Cambridge
Emily Blythe grad student 2012-2013 Cambridge
Jane Cat Donaldson grad student 2009-2014 Cambridge
Miglė Kišonaitė grad student 2014-2015 Cambridge
Xuelu Wang grad student 2012-2016 Cambridge
Ruoqi-Emma Xu grad student 2012-2016 Cambridge
Clare Henry grad student 2013-2017 Cambridge
Margherite Guiata grad student 2016-2017 Cambridge
Thomas Cotton grad student 2015-2019 Cambridge
Joseph McLoughlin grad student 2015-2019 Cambridge
Richard Zhou grad student 2019-2020 Cambridge
Teodors Pantelejevs grad student 2015-2021 Cambridge
Matthew Ratcliff grad student 2016-2021 Cambridge

Collaborators

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Florian Hollfelder collaborator 2005- Cambridge (Chemistry Tree)
David Spring collaborator 2010- Cambridge (Chemistry Tree)
Andrea Balan collaborator 2016- University of São Paulo - Institute of Biomedical Science
Morten Grotli collaborator 2018- University of Gothenburg, Sweden
Christopher Abell collaborator 2004-2020 University of Cambridge (UK) (Chemistry Tree)
BETA: Related publications

Publications

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Stockwell SR, Scott DE, Fischer G, et al. (2024) Selective Aurora A-TPX2 Interaction Inhibitors Have Efficacy as Targeted Antimitotic Agents. Journal of Medicinal Chemistry
Fischer K, Lulla A, So TY, et al. (2024) Rapid discovery of monoclonal antibodies by microfluidics-enabled FACS of single pathogen-specific antibody-secreting cells. Nature Biotechnology
Pantelejevs T, Zuazua-Villar P, Koczy O, et al. (2023) A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science. 14: 13915-13923
Cioffi VB, de Castro-Amarante MF, Lulla A, et al. (2023) SARS-CoV-2 Spike protein peptides displayed in the Pyrococcus furiosus RAD system preserve epitopes antigenicity, immunogenicity, and virus-neutralizing activity of antibodies. Scientific Reports. 13: 16821
Yam-Puc JC, Hosseini Z, Horner EC, et al. (2023) Age-associated B cells predict impaired humoral immunity after COVID-19 vaccination in patients receiving immune checkpoint blockade. Nature Communications. 14: 3292
Dimitrijevs P, Makrecka-Kuka M, Bogucka A, et al. (2023) Development of isoselenazolium chlorides as selective pyruvate kinase isoform M2 inhibitors. European Journal of Medicinal Chemistry. 257: 115504
Knyphausen P, Rangel Pereira M, Brear P, et al. (2023) Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture. Nature Communications. 14: 768
Nain-Perez A, Nilsson O, Lulla A, et al. (2023) Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators. European Journal of Medicinal Chemistry. 250: 115177
Brear P, De Fusco C, Atkinson EL, et al. (2022) A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action. Rsc Medicinal Chemistry. 13: 1420-1426
Battisti UM, Gao C, Nilsson O, et al. (2022) Serendipitous Identification of a Covalent Activator of Liver Pyruvate Kinase. Chembiochem : a European Journal of Chemical Biology
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