Dan Donnelly

University of Leeds, UK 
"Dan Donnelly"
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Gómez Santiago C, Paci E, Donnelly D. (2018) A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics. Biochemical and Biophysical Research Communications. 498: 359-365
Weaver RE, Carlos Mobarec J, Wigglesworth MJ, et al. (2016) High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochemical Pharmacology
Graaf C, Donnelly D, Wootten D, et al. (2016) Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews. 68: 954-1013
Dods RL, Donnelly D. (2015) The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Bioscience Reports. 36: e00285
Weaver RE, Wigglesworth MJ, Donnelly D. (2014) A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. Peptides. 61: 83-7
Al-Sabah S, Al-Fulaij M, Shaaban G, et al. (2014) The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively. Plos One. 9: e106890
Kumar A, Gopalswamy M, Wishart C, et al. (2014) N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity. Acs Chemical Biology. 9: 2465-70
Donnelly D. (2012) The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology. 166: 27-41
Mann RJ, Al-Sabah S, de Maturana RL, et al. (2010) Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 31: 2289-93
Chapman KL, Kinsella GK, Cox A, et al. (2010) Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH. Journal of Molecular Biology. 401: 433-50
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