Dan Donnelly
Affiliations: | University of Leeds, UK |
Area:
GPCRs/Modelling/PharmacologyGoogle:
"Dan Donnelly"Parents
Sign in to add mentor| Tom Blundell | grad student | 1988-1991 | Birkbeck College |
| John Findlay | post-doc | University of Leeds |
Children
Sign in to add trainee| Suleiman Al-Sabah | grad student | University of Leeds, UK | |
| Rakel Lopez deMaturana | grad student | University of Leeds, UK | |
| Rachel Dods | grad student | University of Leeds, UK | |
| James Ellis | grad student | University of Leeds, UK | |
| Carla Gomez-Santiago | grad student | University of Leeds, UK | |
| James Henderson | grad student | University of Leeds, UK | |
| Rosalind Mann | grad student | University of Leeds, UK | |
| Philip Miller | grad student | University of Leeds, UK | |
| Nasr Nasr | grad student | University of Leeds, UK | |
| John Sinfield | grad student | University of Leeds, UK | |
| Janet Treece-Birch | grad student | University of Leeds, UK | |
| Richard Weaver | grad student | University of Leeds, UK | |
| Angie Willshaw | grad student | University of Leeds, UK | |
| Clare Wishart | grad student | University of Leeds, UK | |
| Claudia Zilian | grad student | University of Leeds, UK | |
| Stuart Maudsley | grad student | 1995-1996 | University of Leeds, UK (Neurotree) |
BETA: Related publications
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Publications
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| Gómez Santiago C, Paci E, Donnelly D. (2018) A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics. Biochemical and Biophysical Research Communications. 498: 359-365 |
| Weaver RE, Carlos Mobarec J, Wigglesworth MJ, et al. (2016) High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5. Biochemical Pharmacology |
| Graaf C, Donnelly D, Wootten D, et al. (2016) Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews. 68: 954-1013 |
| Dods RL, Donnelly D. (2015) The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling. Bioscience Reports. 36: e00285 |
| Weaver RE, Wigglesworth MJ, Donnelly D. (2014) A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity. Peptides. 61: 83-7 |
| Al-Sabah S, Al-Fulaij M, Shaaban G, et al. (2014) The GIP receptor displays higher basal activity than the GLP-1 receptor but does not recruit GRK2 or arrestin3 effectively. Plos One. 9: e106890 |
| Kumar A, Gopalswamy M, Wishart C, et al. (2014) N-terminal phosphorylation of parathyroid hormone (PTH) abolishes its receptor activity. Acs Chemical Biology. 9: 2465-70 |
| Donnelly D. (2012) The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology. 166: 27-41 |
| Mann RJ, Al-Sabah S, de Maturana RL, et al. (2010) Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 31: 2289-93 |
| Chapman KL, Kinsella GK, Cox A, et al. (2010) Interactions of the melanocortin-4 receptor with the peptide agonist NDP-MSH. Journal of Molecular Biology. 401: 433-50 |