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Alan Healy - Publications

Affiliations: 
2015- Chemistry Yale University, New Haven, CT 
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 DiBello M, Healy AR, Nikolayevskiy H, Xu Z, Herzon SB. Structure Elucidation of Secondary Metabolites: Current Frontiers and Lingering Pitfalls. Accounts of Chemical Research. PMID 37220079 DOI: 10.1021/acs.accounts.3c00183  0.716
2019 Healy AR, Wernke KM, Kim CS, Lees NR, Crawford JM, Herzon SB. Addendum: Synthesis and reactivity of precolibactin 886. Nature Chemistry. PMID 31719668 DOI: 10.1038/S41557-019-0383-X  0.68
2019 Healy AR, Wernke KM, Kim CS, Lees NR, Crawford JM, Herzon SB. Synthesis and reactivity of precolibactin 886. Nature Chemistry. 11: 890-898. PMID 31548676 DOI: 10.1038/S41557-019-0338-2  0.735
2019 Xue M, Kim CS, Healy AR, Wernke KM, Wang Z, Frischling MC, Shine EE, Wang W, Herzon SB, Crawford JM. Structure elucidation of colibactin and its DNA cross-links. Science (New York, N.Y.). PMID 31395743 DOI: 10.1126/Science.Aax2685  0.734
2019 Coufalova D, Remnant L, Hernychova L, Muller P, Healy A, Kannan S, Vojtesek B, Westwood N, Verma CS, Vojtesek B, Hupp TR, Houston DR. An inter-subunit protein-peptide interface that stabilizes the specific activity and oligomerization of the AAA+ chaperone Reptin. Journal of Proteomics. PMID 30862565 DOI: 10.1016/J.Jprot.2019.02.012  0.531
2018 Shine EE, Xue M, Patel JR, Healy AR, Surovtseva YV, Herzon SB, Crawford JM. Model colibactins exhibit human cell genotoxicity in the absence of host bacteria. Acs Chemical Biology. PMID 30403848 DOI: 10.1021/Acschembio.8B00714  0.604
2017 Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM. ClbS is a cyclopropane hydrolase that confers colibactin resistance. Journal of the American Chemical Society. PMID 29112397 DOI: 10.1021/Jacs.7B09971  0.631
2017 Healy AR, Herzon SB. Molecular basis of gut microbiome-associated colorectal cancer: A synthetic perspective. Journal of the American Chemical Society. PMID 28949546 DOI: 10.1021/Jacs.7B07807  0.665
2017 Guntaka NS, Healy AR, Crawford JM, Herzon SB, Bruner SD. Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway. Acs Chemical Biology. PMID 28846367 DOI: 10.1021/Acschembio.7B00479  0.653
2017 Trautman E, Healy AR, Shine E, Herzon SB, Crawford JM. Domain-targeted metabolomics delineates the heterocycle assembly steps of colibactin biosynthesis. Journal of the American Chemical Society. PMID 28240912 DOI: 10.1021/Jacs.7B00659  0.585
2016 Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB. A Mechanistic Model for Colibactin-Induced Genotoxicity. Journal of the American Chemical Society. 138: 15563-15570. PMID 27934011 DOI: 10.1021/Jacs.6B10354  0.723
2016 Healy AR, Vizcaino MI, Crawford JM, Herzon SB. A convergent and modular synthesis of candidate precolibactins. Structural revision of precolibactin A. Journal of the American Chemical Society. PMID 27025153 DOI: 10.1021/Jacs.6B02276  0.652
2015 Healy AR, Izumikawa M, Slawin AM, Shin-Ya K, Westwood NJ. Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis. Angewandte Chemie (Weinheim An Der Bergstrasse, Germany). 127: 4118-4122. PMID 27087707 DOI: 10.1002/ange.201411141  0.546
2015 Healy AR, Westwood NJ. Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction. Organic & Biomolecular Chemistry. 13: 10527-31. PMID 26337398 DOI: 10.1039/c5ob01771h  0.499
2015 Healy AR, Izumikawa M, Slawin AM, Shin-Ya K, Westwood NJ. Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis. Angewandte Chemie (International Ed. in English). 54: 4046-50. PMID 25650886 DOI: 10.1002/Anie.201411141  0.586
2015 Healy AR, Vinale F, Lorito M, Westwood NJ. Total synthesis and biological evaluation of the tetramic acid based natural product harzianic acid and its stereoisomers. Organic Letters. 17: 692-5. PMID 25629709 DOI: 10.1021/ol503717r  0.519
2015 Healy AR, Houston DR, Remnant L, Huart AS, Brychtova V, Maslon MM, Meers O, Muller P, Krejci A, Blackburn EA, Vojtesek B, Hernychova L, Walkinshaw MD, Westwood NJ, Hupp TR. Discovery of a novel ligand that modulates the protein-protein interactions of the AAA+ superfamily oncoprotein reptin Chemical Science. 6: 3109-3116. DOI: 10.1039/c4sc03885a  0.445
2012 Taladriz A, Healy A, Flores Pérez EJ, Herrero García V, Ríos Martínez C, Alkhaldi AA, Eze AA, Kaiser M, de Koning HP, Chana A, Dardonville C. Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of Medicinal Chemistry. 55: 2606-22. PMID 22390399 DOI: 10.1021/Jm2014259  0.302
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