| Year |
Citation |
Score |
| 2023 |
Kreutzer AG, Parrocha CMT, Haerianardakani S, Guaglianone G, Nguyen JT, Diab MN, Yong W, Perez-Rosendahl M, Head E, Nowick JS. Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue. Acs Central Science. 10: 104-121. PMID 38292607 DOI: 10.1021/acscentsci.3c00592 |
0.302 |
|
| 2023 |
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Head E, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311 |
0.616 |
|
| 2023 |
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37438872 DOI: 10.1002/alz.13382 |
0.349 |
|
| 2023 |
Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, ... Head E, et al. Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia. Neurobiology of Aging. 128: 43-48. PMID 37156179 DOI: 10.1016/j.neurobiolaging.2023.04.004 |
0.313 |
|
| 2023 |
Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimer's & Dementia (Amsterdam, Netherlands). 15: e12419. PMID 37035460 DOI: 10.1002/dad2.12419 |
0.542 |
|
| 2023 |
Delabar JM, Lagarde J, Fructuoso M, Mohammad A, Bottlaender M, Doran E, Lott I, Rivals I, Schmitt FA, Head E, Sarazin M, Potier MC. Increased plasma DYRK1A with aging may protect against neurodegenerative diseases. Translational Psychiatry. 13: 111. PMID 37015911 DOI: 10.1038/s41398-023-02419-0 |
0.345 |
|
| 2023 |
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Medrxiv : the Preprint Server For Health Sciences. PMID 36945447 DOI: 10.1101/2023.03.10.23287109 |
0.801 |
|
| 2022 |
Thorwald MA, Silva J, Head E, Finch CE. Amyloid futures in the expanding pathology of brain aging and dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36536382 DOI: 10.1002/alz.12896 |
0.326 |
|
| 2022 |
Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2212954119. PMID 36343257 DOI: 10.1073/pnas.2212954119 |
0.382 |
|
| 2022 |
Andrews EJ, Martini AC, Head E. Exploring the role of sex differences in Alzheimer's disease pathogenesis in Down syndrome. Frontiers in Neuroscience. 16: 954999. PMID 36033603 DOI: 10.3389/fnins.2022.954999 |
0.35 |
|
| 2022 |
Jin M, Xu R, Wang L, Alam MM, Ma Z, Zhu S, Martini AC, Jadali A, Bernabucci M, Xie P, Kwan KY, Pang ZP, Head E, Liu Y, Hart RP, et al. Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer's disease. Cell Stem Cell. 29: 1135-1153.e8. PMID 35803230 DOI: 10.1016/j.stem.2022.06.007 |
0.312 |
|
| 2022 |
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 185: 2213-2233.e25. PMID 35750033 DOI: 10.1016/j.cell.2022.05.017 |
0.639 |
|
| 2022 |
Kiani Shabestari S, Morabito S, Danhash EP, McQuade A, Sanchez JR, Miyoshi E, Chadarevian JP, Claes C, Coburn MA, Hasselmann J, Hidalgo J, Tran KN, Martini AC, Chang Rothermich W, Pascual J, ... Head E, et al. Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice. Cell Reports. 39: 110961. PMID 35705056 DOI: 10.1016/j.celrep.2022.110961 |
0.762 |
|
| 2022 |
Lao P, Zimmerman ME, Hartley SL, Gutierrez J, Keator D, Igwe KC, Laing KK, Cotton-Samuel D, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, et al. Obstructive sleep apnea, cerebrovascular disease, and amyloid in older adults with Down syndrome across the Alzheimer's continuum. Sleep Advances : a Journal of the Sleep Research Society. 3: zpac013. PMID 35669316 DOI: 10.1093/sleepadvances/zpac013 |
0.311 |
|
| 2022 |
Moni F, Petersen ME, Zhang F, Lao PJ, Zimmerman ME, Gu Y, Gutierrez J, Rizvi B, Laing KK, Igwe KC, Sathishkumar M, Keator D, Andrews H, Krinsky-McHale S, Head E, et al. Probing the proteome to explore potential correlates of increased Alzheimer's-related cerebrovascular disease in adults with Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35212182 DOI: 10.1002/alz.12627 |
0.313 |
|
| 2021 |
Sordo L, Martini AC, Houston EF, Head E, Gunn-Moore D. Neuropathology of Aging in Cats and its Similarities to Human Alzheimer's Disease. Frontiers in Aging. 2: 684607. PMID 35822024 DOI: 10.3389/fragi.2021.684607 |
0.387 |
|
| 2021 |
Kumar A, Doran E, Martini AC, Head E, Kirby K. CAA and related co-morbidities in Down syndrome and Alzheimer disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058726. PMID 34971184 DOI: 10.1002/alz.058726 |
0.357 |
|
| 2021 |
Pivtoraiko VN, Racic T, Abrahamson EE, Villemagne VL, Handen BL, Lott IT, Head E, Ikonomovic MD. Postmortem Neocortical H-PiB Binding and Levels of Unmodified and Pyroglutamate Aβ in Down Syndrome and Sporadic Alzheimer's Disease. Frontiers in Aging Neuroscience. 13: 728739. PMID 34489686 DOI: 10.3389/fnagi.2021.728739 |
0.308 |
|
| 2021 |
Radhakrishnan H, Ubele M, Krumholz SM, Boaz K, Mefford JL, Jones ED, Meacham B, Smiley J, Puskás LG, Powell DK, Norris CM, Stark CEL, Head E. Tacrolimus protects against age-associated microstructural changes in the beagle brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33952632 DOI: 10.1523/JNEUROSCI.0361-21.2021 |
0.401 |
|
| 2021 |
Hendrix JA, Airey DC, Britton A, Burke AD, Capone GT, Chavez R, Chen J, Chicoine B, Costa ACS, Dage JL, Doran E, Esbensen A, Evans CL, Faber KM, Foroud TM, ... ... Head E, et al. Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study. Journal of Clinical Medicine. 10. PMID 33924960 DOI: 10.3390/jcm10091907 |
0.35 |
|
| 2020 |
Martini AC, Helman AM, McCarty KL, Lott IT, Doran E, Schmitt FA, Head E. Distribution of microglial phenotypes as a function of age and Alzheimer's disease neuropathology in the brains of people with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12113. PMID 33088896 DOI: 10.1002/dad2.12113 |
0.348 |
|
| 2020 |
Thalman S, Van Pelt KL, Lin AL, Johnson NF, Jicha G, Caban-Holt A, Robertson W, Lightner D, Powell D, Head E, Schmitt F. A preliminary study of cerebral blood flow, aging and dementia in people with Down syndrome. Journal of Intellectual Disability Research : Jidr. PMID 32996650 DOI: 10.1111/jir.12784 |
0.333 |
|
| 2020 |
Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, et al. Alzheimer's-related cerebrovascular disease in Down syndrome. Annals of Neurology. PMID 32944999 DOI: 10.1002/Ana.25905 |
0.433 |
|
| 2020 |
Lao PJ, Gutierrez J, Keator D, Rizvi B, Banerjee A, Igwe KC, Laing KK, Sathishkumar M, Moni F, Andrews H, Krinsky-McHale S, Head E, Lee JH, Lai F, Yassa MA, et al. Alzheimer's-related cerebrovascular disease in Down syndrome. Annals of Neurology. PMID 32944999 DOI: 10.1002/ana.25905 |
0.321 |
|
| 2020 |
Van Pelt KL, Koehl L, Caban-Holt A, Anderson-Mooney A, Head E, Schmitt FA. Feasibility of dual-task gait to estimate Alzheimer's related cognitive decline in Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12092. PMID 32875058 DOI: 10.1002/Dad2.12092 |
0.429 |
|
| 2020 |
Lanzillotta C, Zuliani I, Tramutola A, Barone E, Blarzino C, Folgiero V, Caforio M, Valentini D, Villani A, Locatelli F, Butterfield DA, Head E, Perluigi M, Abisambra JF, Di Domenico F. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Progress in Neurobiology. 101892. PMID 32795489 DOI: 10.1016/J.Pneurobio.2020.101892 |
0.39 |
|
| 2020 |
Handen BL, Lott IT, Christian BT, Schupf N, OBryant S, Mapstone M, Fagan AM, Lee JH, Tudorascu D, Wang MC, Head E, Klunk W, Ances B, Lai F, Zaman S, et al. The Alzheimer's Biomarker Consortium-Down Syndrome: Rationale and methodology. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12065. PMID 32775597 DOI: 10.1002/Dad2.12065 |
0.415 |
|
| 2020 |
Petersen ME, Zhang F, Schupf N, Krinsky-McHale SJ, Hall J, Mapstone M, Cheema A, Silverman W, Lott I, Rafii MS, Handen B, Klunk W, Head E, Christian B, Foroud T, et al. Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12039. PMID 32626817 DOI: 10.1002/Dad2.12039 |
0.399 |
|
| 2020 |
Head E, Ances B. Biomarkers in Down syndrome can help us understand Alzheimer's disease. Lancet (London, England). 395: 1951-1953. PMID 32593327 DOI: 10.1016/S0140-6736(20)30916-8 |
0.334 |
|
| 2020 |
Snyder HM, Bain LJ, Brickman AM, Carrillo MC, Esbensen AJ, Espinosa JM, Fernandez F, Fortea J, Hartley SL, Head E, Hendrix J, Kishnani PS, Lai F, Lao P, Lemere C, et al. Further understanding the connection between Alzheimer's disease and Down syndrome. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32544310 DOI: 10.1002/Alz.12112 |
0.429 |
|
| 2020 |
Mapstone M, Gross TJ, Macciardi F, Cheema AK, Petersen M, Head E, Handen BL, Klunk WE, Christian BT, Silverman W, Lott IT, Schupf N. Metabolic correlates of prevalent mild cognitive impairment and Alzheimer's disease in adults with Down syndrome. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12028. PMID 32258359 DOI: 10.1002/Dad2.12028 |
0.376 |
|
| 2020 |
Lin AL, Parikh I, Yanckello LM, White RS, Hartz AMS, Taylor CE, McCulloch SD, Thalman SW, Xia M, McCarty K, Ubele M, Head E, Hyder F, Sanganahalli BG. APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease. Neurobiology of Disease. 104834. PMID 32173556 DOI: 10.1016/J.Nbd.2020.104834 |
0.416 |
|
| 2020 |
Tramutola A, Lanzillotta C, Di Domenico F, Head E, Butterfield DA, Perluigi M, Barone E. Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome. Neurobiology of Disease. 104772. PMID 31987911 DOI: 10.1016/J.Nbd.2020.104772 |
0.394 |
|
| 2020 |
Martini AC, Helman AM, McCarty K, Lott IT, Doran E, Schmitt FA, Head E. Microglial phenotypes in the brains of aging people with Down syndrome and Alzheimer disease Alzheimer's & Dementia. 16. DOI: 10.1002/alz.041283 |
0.334 |
|
| 2019 |
Cohen AD, Head E, Lee JH. Alzheimer's disease in aging Down syndrome. Developmental Neurobiology. 79: 611-612. PMID 31545018 DOI: 10.1002/Dneu.22717 |
0.409 |
|
| 2019 |
Gross TJ, Doran E, Cheema AK, Head E, Lott IT, Mapstone M. Plasma Metabolites Related to Cellular Energy Metabolism Are Altered in Adults with Down Syndrome and Alzheimer's Disease. Developmental Neurobiology. PMID 31419370 DOI: 10.1002/Dneu.22716 |
0.372 |
|
| 2019 |
Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD. Neuropathological correlates of amyloid PET imaging in Down syndrome. Developmental Neurobiology. PMID 31379087 DOI: 10.1002/Dneu.22713 |
0.46 |
|
| 2019 |
Lott IT, Head E. Dementia in Down syndrome: unique insights for Alzheimer disease research. Nature Reviews. Neurology. PMID 30733618 DOI: 10.1038/s41582-018-0132-6 |
0.463 |
|
| 2019 |
Van Pelt K, McCarty K, Davis R, Lykins J, Jicha GA, Caban-Holt AM, Lighner D, Robertson W, Brothers S, Lin A, Powell DK, Head E, Schmitt FA. P3-405: AGING IN DOWN SYNDROME: AGE-ASSOCIATED BRAIN METABOLITE CHANGES Alzheimer's & Dementia. 15: P1109-P1109. DOI: 10.1016/J.Jalz.2019.06.3439 |
0.394 |
|
| 2018 |
Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chételat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, ... ... Head E, et al. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30555031 DOI: 10.1016/J.Jalz.2018.09.009 |
0.594 |
|
| 2018 |
Helman AM, Siever M, McCarty KL, Lott IT, Doran E, Abner EL, Schmitt FA, Head E. Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30452414 DOI: 10.3233/Jad-180589 |
0.483 |
|
| 2018 |
Triani F, Tramutola A, Di Domenico F, Sharma N, Allan Butterfield D, Head E, Perluigi M, Barone E. Biliverdin reductase-A impairment links brain insulin resistance with increased Aβ production in an animal model of aging: Implications for Alzheimer disease. Biochimica Et Biophysica Acta. PMID 29981845 DOI: 10.1016/J.Bbadis.2018.07.005 |
0.4 |
|
| 2018 |
Head E, Powell DK, Schmitt FA. Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis. Frontiers in Aging Neuroscience. 10: 191. PMID 29977201 DOI: 10.3389/fnagi.2018.00191 |
0.446 |
|
| 2018 |
Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Head E, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757 |
0.622 |
|
| 2018 |
Miranda AM, Herman M, Cheng R, Nahmani E, Barrett G, Micevska E, Fontaine G, Potier MC, Head E, Schmitt FA, Lott IT, Jiménez-Velázquez IZ, Antonarakis SE, Di Paolo G, Lee JH, et al. Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease. Cell Reports. 23: 2967-2975. PMID 29874583 DOI: 10.1016/J.Celrep.2018.05.011 |
0.474 |
|
| 2018 |
Kumar S, Frost JL, Cotman CW, Head E, Palmour R, Lemere CA, Walter J. Deposition of phosphorylated amyloid-β in brains of aged nonhuman primates and canines. Brain Pathology (Zurich, Switzerland). 28: 427-430. PMID 29740941 DOI: 10.1111/Bpa.12573 |
0.622 |
|
| 2018 |
Rusbridge C, Salguero FJ, David MA, Faller KME, Bras JT, Guerreiro RJ, Richard-Londt AC, Grainger D, Head E, Brandner SGP, Summers B, Hardy J, Tayebi M. An Aged Canid with Behavioral Deficits Exhibits Blood and Cerebrospinal Fluid Amyloid Beta Oligomers. Frontiers in Aging Neuroscience. 10: 7. PMID 29441010 DOI: 10.3389/Fnagi.2018.00007 |
0.498 |
|
| 2018 |
Head E. F5-01-02: Cerebrovascular Neuropathology As A Function Of Age In Down Syndrome Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2969 |
0.305 |
|
| 2017 |
Head E, Phelan MJ, Doran E, Kim RC, Poon WW, Schmitt FA, Lott IT. Cerebrovascular pathology in Down syndrome and Alzheimer disease. Acta Neuropathologica Communications. 5: 93. PMID 29195510 DOI: 10.1186/S40478-017-0499-4 |
0.729 |
|
| 2017 |
Head E, Helman A, Powell D, Schmitt F. Down syndrome, beta-amyloid and neuroimaging. Free Radical Biology & Medicine. PMID 28935420 DOI: 10.1016/j.freeradbiomed.2017.09.013 |
0.44 |
|
| 2017 |
O'Reilly MA, Jones RM, Barrett E, Schwab A, Head E, Hynynen K. Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging. Theranostics. 7: 3573-3584. PMID 28912896 DOI: 10.7150/thno.20621 |
0.422 |
|
| 2017 |
Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA. mTOR IN DOWN SYNDROME: ROLE in Aß and TAU NEUROPATHOLOGY and TRANSITION to ALZHEIMER DISEASE-LIKE DEMENTIA. Free Radical Biology & Medicine. PMID 28807816 DOI: 10.1016/J.Freeradbiomed.2017.08.009 |
0.432 |
|
| 2017 |
Barone E, Arena A, Head E, Butterfield DA, Perluigi M. Disturbance of redox homeostasis in Down Syndrome: role of iron dysmetabolism. Free Radical Biology & Medicine. PMID 28705658 DOI: 10.1016/J.Freeradbiomed.2017.07.009 |
0.347 |
|
| 2017 |
Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinos MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, ... ... Head E, et al. Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28463681 DOI: 10.1016/J.Jalz.2017.03.007 |
0.414 |
|
| 2017 |
LeVine H, Spielmann HP, Matveev S, Cauvi FM, Murphy MP, Beckett TL, McCarty K, Lott IT, Doran E, Schmitt F, Head E. Down syndrome: age-dependence of PiB binding in postmortem frontal cortex across the lifespan. Neurobiology of Aging. PMID 28385551 DOI: 10.1016/J.Jalz.2017.06.474 |
0.44 |
|
| 2017 |
Hainsworth AH, Allan SM, Boltze J, Cunningham C, Farris C, Head E, Ihara M, Isaacs JD, Kalaria RN, Lesnik Oberstein SA, Moss MB, Nitzsche B, Rosenberg GA, Rutten JW, Salkovic-Petrisic M, et al. Translational models for vascular cognitive impairment: a review including larger species. Bmc Medicine. 15: 16. PMID 28118831 DOI: 10.1186/S12916-017-0793-9 |
0.325 |
|
| 2017 |
Helman AM, Murphy P, McCarty K, Schmitt FA, Head E. [P4-275]: CEREBRAL AMYLOID ANGIOPATHY AND MICROHEMORRHAGES IN THE OCCIPITAL CORTEX OF AGING ADULTS WITH DOWN SYNDROME Alzheimer's & Dementia. 13: P1390-P1391. DOI: 10.1016/J.Jalz.2017.06.2144 |
0.361 |
|
| 2017 |
Tramutola A, Butterfield DA, Head E, Barone E, di Domenico F, Perluigi M. [P3-160]: ABERRANT POLYUBIQUITOME PROFILE IN DOWN SYNDROME AND ALZHEIMER DISEASE BRAIN Alzheimer's & Dementia. 13: P995-P995. DOI: 10.1016/J.Jalz.2017.06.1372 |
0.375 |
|
| 2017 |
Allan Butterfield D, Di Domenico F, Tramutola A, Head E, Perluigi M. Oxidative Stress and mTOR Activation in Down Syndrome Brain: Roles in Aβ42 and Tau Neuropathology and Transition to Alzheimer Disease-Like Dementia Free Radical Biology and Medicine. 112: 70. DOI: 10.1016/J.Freeradbiomed.2017.10.099 |
0.434 |
|
| 2017 |
Head E, Gunn-Moore D. Neuropathology of Feline Dementia Springer International Publishing. 103-111. DOI: 10.1007/978-3-319-53219-6_6 |
0.503 |
|
| 2016 |
Doran E, Keator D, Head E, Phelan MJ, Kim R, Totoiu M, Barrio JR, Small GW, Potkin SG, Lott IT. Down Syndrome, Partial Trisomy 21, and Absence of Alzheimer's Disease: The Role of APP. Journal of Alzheimer's Disease : Jad. PMID 27983553 DOI: 10.3233/Jad-160836 |
0.471 |
|
| 2016 |
Barone E, Head E, Butterfield DA, Perluigi M. HNE-modified proteins in Down Syndrome: involvement in development of Alzheimer disease neuropathology. Free Radical Biology & Medicine. PMID 27838436 DOI: 10.1016/J.Freeradbiomed.2016.10.508 |
0.437 |
|
| 2016 |
Davis PR, Giannini G, Rudolph K, Calloway N, Royer CM, Beckett TL, Murphy MP, Bresch F, Pagani D, Platt T, Wang X, Donovan AS, Sudduth TL, Lou W, Abner E, ... ... Head E, et al. Aβ vaccination in combination with behavioral enrichment in aged beagles: effects on cognition, Aβ, and microhemorrhages. Neurobiology of Aging. 49: 86-99. PMID 27776266 DOI: 10.1016/J.Neurobiolaging.2016.09.007 |
0.515 |
|
| 2016 |
Lin AL, Powell D, Caban-Holt A, Jicha G, Robertson W, Gold BT, Davis R, Abner E, Wilcock DM, Schmitt FA, Head E. (1)H-MRS metabolites in adults with Down syndrome: Effects of dementia. Neuroimage. Clinical. 11: 728-35. PMID 27330972 DOI: 10.1016/J.Nicl.2016.06.001 |
0.376 |
|
| 2016 |
Day RJ, McCarty KL, Ockerse KE, Head E, Rohn TT. Proteolytic Cleavage of Apolipoprotein E in the Down Syndrome Brain. Aging and Disease. 7: 267-77. PMID 27330841 DOI: 10.14336/AD.2015.1020 |
0.441 |
|
| 2016 |
Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, et al. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 31. PMID 27112350 DOI: 10.1186/S13024-016-0095-2 |
0.373 |
|
| 2016 |
Tanifum EA, Ghaghada K, Vollert C, Head E, Eriksen JL, Annapragada A. A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. Journal of Alzheimer's Disease : Jad. PMID 27031484 DOI: 10.3233/Jad-151124 |
0.365 |
|
| 2016 |
Tramutola A, Pupo G, Di Domenico F, Barone E, Arena A, Lanzillotta C, Broekaart D, Blarzino C, Head E, Allan Butterfield D, Perluigi M. Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. Journal of Alzheimer's Disease : Jad. PMID 26967221 DOI: 10.3233/Jad-151105 |
0.403 |
|
| 2016 |
Anderson-Mooney AJ, Schmitt FA, Head E, Lott IT, Heilman KM. Gait dyspraxia as a clinical marker of cognitive decline in Down syndrome: A review of theory and proposed mechanisms. Brain and Cognition. 104: 48-57. PMID 26930369 DOI: 10.1016/J.Bandc.2016.02.007 |
0.447 |
|
| 2016 |
Youssef SA, Capucchio MT, Rofina JE, Chambers JK, Uchida K, Nakayama H, Head E. Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases. Veterinary Pathology. PMID 26869150 DOI: 10.1177/0300985815623997 |
0.504 |
|
| 2016 |
Head E, Lott IT, Wilcock DM, Lemere CA. Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology. Current Alzheimer Research. 13: 18-29. PMID 26651341 DOI: 10.2174/1567205012666151020114607 |
0.486 |
|
| 2016 |
Head E, Fitch JC, Davis PR, Wilcock DM, Schmitt FA. O3-04-05: Frontal Cortex Microhemorrhages in Aging Adults with Down Syndrome: A Potentially Important Contributor to Alzheimer's Disease Pathogenesis Alzheimer's & Dementia. 12: P293-P293. DOI: 10.1016/J.Jalz.2016.06.528 |
0.361 |
|
| 2016 |
Tramutola A, Domenico FD, Barone E, Head E, Butterfield DA, Perluigi M. Ubiquitome Profile in Down Syndrome Brain: Understanding the Mechanisms of Neurodegeneration Free Radical Biology and Medicine. 100: S167. DOI: 10.1016/J.Freeradbiomed.2016.10.441 |
0.455 |
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| 2015 |
Fosso MY, McCarty KL, Head E, Garneau-Tsodikova S, Levine Iii H. Differential effects of structural modifications on the competition of chalcones for the PIB amyloid imaging ligand-binding site in Alzheimer's disease brain and synthetic Aβ fibrils. Acs Chemical Neuroscience. PMID 26682772 DOI: 10.1021/Acschemneuro.5B00266 |
0.363 |
|
| 2015 |
Wilcock DM, Schmitt FA, Head E. Cerebrovascular contributions to aging and Alzheimer disease in down syndrome. Biochimica Et Biophysica Acta. PMID 26593849 DOI: 10.1016/J.Bbadis.2015.11.007 |
0.5 |
|
| 2015 |
Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiology of Aging. 36: 2468-74. PMID 26103884 DOI: 10.1016/J.Neurobiolaging.2015.05.016 |
0.431 |
|
| 2015 |
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Head E, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157 |
0.689 |
|
| 2015 |
Di Domenico F, Pupo G, Mancuso C, Barone E, Paolini F, Arena A, Blarzino C, Schmitt FA, Head E, Butterfield DA, Perluigi M. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 44: 1107-20. PMID 25391381 DOI: 10.3233/Jad-141254 |
0.391 |
|
| 2014 |
Rohn TT, McCarty KL, Love JE, Head E. Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome? Journal of Parkinson's Disease and Alzheimer's Disease. 1. PMID 25594074 DOI: 10.13188/2376-922X.1000004 |
0.36 |
|
| 2014 |
Head E, Schmitt FA. Con: are we ready to translate Alzheimer's disease-modifying therapies to people with down syndrome? Alzheimer's Research & Therapy. 6: 61. PMID 25478026 DOI: 10.1186/S13195-014-0061-6 |
0.384 |
|
| 2014 |
Vite CH, Head E. Aging in the canine and feline brain. The Veterinary Clinics of North America. Small Animal Practice. 44: 1113-29. PMID 25441628 DOI: 10.1016/j.cvsm.2014.07.008 |
0.488 |
|
| 2014 |
Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, ... ... Head E, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899 |
0.452 |
|
| 2014 |
Butterfield DA, Di Domenico F, Swomley AM, Head E, Perluigi M. Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. The Biochemical Journal. 463: 177-89. PMID 25242166 DOI: 10.1042/Bj20140772 |
0.445 |
|
| 2014 |
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Head E, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491 |
0.669 |
|
| 2014 |
Cenini G, Fiorini A, Sultana R, Perluigi M, Cai J, Klein JB, Head E, Butterfield DA. An investigation of the molecular mechanisms engaged before and after the development of Alzheimer disease neuropathology in Down syndrome: a proteomics approach. Free Radical Biology & Medicine. 76: 89-95. PMID 25151119 DOI: 10.1016/J.Freeradbiomed.2014.08.006 |
0.462 |
|
| 2014 |
Jullienne A, Roberts JM, Pop V, Paul Murphy M, Head E, Bix GJ, Badaut J. Juvenile traumatic brain injury induces long-term perivascular matrix changes alongside amyloid-beta accumulation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1637-45. PMID 25052558 DOI: 10.1038/Jcbfm.2014.124 |
0.776 |
|
| 2014 |
Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. Journal of Alzheimer's Disease : Jad. 42: 1221-7. PMID 25024306 DOI: 10.3233/Jad-132450 |
0.459 |
|
| 2014 |
Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 42: 767-75. PMID 24927707 DOI: 10.3233/Jad-140795 |
0.428 |
|
| 2014 |
Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F. Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochimica Et Biophysica Acta. 1842: 1144-53. PMID 24735980 DOI: 10.1016/J.Bbadis.2014.04.007 |
0.448 |
|
| 2014 |
Davis PR, Head E. Prevention approaches in a preclinical canine model of Alzheimer's disease: benefits and challenges. Frontiers in Pharmacology. 5: 47. PMID 24711794 DOI: 10.3389/fphar.2014.00047 |
0.47 |
|
| 2014 |
Di Domenico F, Pupo G, Tramutola A, Giorgi A, Schininà ME, Coccia R, Head E, Butterfield DA, Perluigi M. Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radical Biology & Medicine. 71: 270-80. PMID 24675226 DOI: 10.1016/J.Freeradbiomed.2014.03.027 |
0.416 |
|
| 2014 |
Powell D, Caban-Holt A, Jicha G, Robertson W, Davis R, Gold BT, Schmitt FA, Head E. Frontal white matter integrity in adults with Down syndrome with and without dementia. Neurobiology of Aging. 35: 1562-9. PMID 24582640 DOI: 10.1016/J.Neurobiolaging.2014.01.137 |
0.414 |
|
| 2014 |
Marchese M, Cowan D, Head E, Ma D, Karimi K, Ashthorpe V, Kapadia M, Zhao H, Davis P, Sakic B. Autoimmune manifestations in the 3xTg-AD model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 39: 191-210. PMID 24150111 DOI: 10.3233/JAD-131490 |
0.465 |
|
| 2014 |
Davis PR, Beckett T, Giannini G, Calloway N, Murphy MP, Barrett EG, Head E. A Combination Approach In A Canine Model Of Aging: Immunotherapy With Behavioral Enrichment Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.05.300 |
0.302 |
|
| 2014 |
Allan Butterfield D, Di Domenico F, Sultana R, Fiorini A, Cenini G, Head E, Perluigi M. Proteomics Insights into Molecular Mechanisms Engaged Prior to and Following Development of Alzheimer’s Disease (AD) Neuropathology in Down Syndrome (DS) Brain: Relevance to Oxidative Stress and Neuropathology of Both DS and AD Free Radical Biology and Medicine. 76: S21. DOI: 10.1016/J.Freeradbiomed.2014.10.468 |
0.399 |
|
| 2013 |
Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochimica Et Biophysica Acta. 1832: 1249-59. PMID 23603808 DOI: 10.1016/J.Bbadis.2013.04.013 |
0.442 |
|
| 2013 |
Roher AE, Cribbs DH, Kim RC, Maarouf CL, Whiteside CM, Kokjohn TA, Daugs ID, Head E, Liebsack C, Serrano G, Belden C, Sabbagh MN, Beach TG. Bapineuzumab alters aβ composition: implications for the amyloid cascade hypothesis and anti-amyloid immunotherapy. Plos One. 8: e59735. PMID 23555764 DOI: 10.1371/journal.pone.0059735 |
0.43 |
|
| 2013 |
Head E. A canine model of human aging and Alzheimer's disease. Biochimica Et Biophysica Acta. 1832: 1384-9. PMID 23528711 DOI: 10.1016/j.bbadis.2013.03.016 |
0.502 |
|
| 2013 |
Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 205-14. PMID 23149553 DOI: 10.1038/Jcbfm.2012.154 |
0.784 |
|
| 2012 |
Head E, Powell D, Gold BT, Schmitt FA. Alzheimer's Disease in Down Syndrome. European Journal of Neurodegenerative Disease. 1: 353-364. PMID 25285303 |
0.396 |
|
| 2012 |
Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 32: 1029-42. PMID 22886019 DOI: 10.3233/JAD-2012-120937 |
0.482 |
|
| 2012 |
Head E, Silverman W, Patterson D, Lott IT. Aging and down syndrome. Current Gerontology and Geriatrics Research. 2012: 412536. PMID 22844278 DOI: 10.1155/2012/412536 |
0.303 |
|
| 2012 |
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Head E, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801 |
0.705 |
|
| 2012 |
Tansley G, Holmes DT, Lütjohann D, Head E, Wellington CL. Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels. Current Gerontology and Geriatrics Research. 2012: 179318. PMID 22649448 DOI: 10.1155/2012/179318 |
0.308 |
|
| 2012 |
Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/J.Ajpath.2011.09.034 |
0.46 |
|
| 2012 |
Saing T, Dick M, Nelson PT, Kim RC, Cribbs DH, Head E. Frontal cortex neuropathology in dementia pugilistica. Journal of Neurotrauma. 29: 1054-70. PMID 22017610 DOI: 10.1089/Neu.2011.1957 |
0.44 |
|
| 2012 |
Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochimica Et Biophysica Acta. 1822: 130-8. PMID 22009041 DOI: 10.1016/J.Bbadis.2011.10.001 |
0.449 |
|
| 2012 |
Dowling AL, Head E. Antioxidants in the canine model of human aging. Biochimica Et Biophysica Acta. 1822: 685-9. PMID 22005070 DOI: 10.1016/j.bbadis.2011.09.020 |
0.514 |
|
| 2012 |
Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Journal of Neurochemistry. 120: 135-46. PMID 22004509 DOI: 10.1111/J.1471-4159.2011.07538.X |
0.428 |
|
| 2012 |
Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 981-7. PMID 21767440 DOI: 10.1017/S1461145711001118 |
0.432 |
|
| 2012 |
Jung KM, Astarita G, Yasar S, Vasilevko V, Cribbs DH, Head E, Cotman CW, Piomelli D. An amyloid β42-dependent deficit in anandamide mobilization is associated with cognitive dysfunction in Alzheimer's disease. Neurobiology of Aging. 33: 1522-32. PMID 21546126 DOI: 10.1016/j.neurobiolaging.2011.03.012 |
0.663 |
|
| 2012 |
Fahnestock M, Marchese M, Head E, Pop V, Michalski B, Milgram WN, Cotman CW. BDNF increases with behavioral enrichment and an antioxidant diet in the aged dog. Neurobiology of Aging. 33: 546-54. PMID 20447733 DOI: 10.1016/J.Jveb.2009.12.005 |
0.784 |
|
| 2012 |
Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiology of Aging. 33: 108-20. PMID 20434811 DOI: 10.1016/J.Neurobiolaging.2010.02.008 |
0.816 |
|
| 2012 |
Head E, Davis R, Caban-Holt A, Dennis B, Jicha G, Powell D, Abner E, Dowling AL, Gold B, Wyss-Coray T, Schmitt F. P2-267: A longitudinal study of aging and the development of Alzheimer's disease in people with Down syndrome Alzheimer's & Dementia. 8: P355-P356. DOI: 10.1016/J.Jalz.2012.05.975 |
0.401 |
|
| 2011 |
Martin SB, Dowling AL, Head E. Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model. Current Neuropharmacology. 9: 651-61. PMID 22654723 DOI: 10.2174/157015911798376217 |
0.489 |
|
| 2011 |
Astarita G, Jung KM, Vasilevko V, Dipatrizio NV, Martin SK, Cribbs DH, Head E, Cotman CW, Piomelli D. Elevated stearoyl-CoA desaturase in brains of patients with Alzheimer's disease. Plos One. 6: e24777. PMID 22046234 DOI: 10.1371/journal.pone.0024777 |
0.639 |
|
| 2011 |
Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 22: 767-72. PMID 21876463 DOI: 10.1097/Wnr.0B013E32834Ae348 |
0.37 |
|
| 2011 |
Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neuroscience Letters. 501: 92-5. PMID 21763754 DOI: 10.1016/J.Neulet.2011.06.054 |
0.444 |
|
| 2011 |
Lott IT, Doran E, Nguyen VQ, Tournay A, Head E, Gillen DL. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. American Journal of Medical Genetics. Part A. 155: 1939-48. PMID 21739598 DOI: 10.1002/Ajmg.A.34114 |
0.368 |
|
| 2011 |
Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies. Acta Neuropathologica. 121: 571-87. PMID 21516511 DOI: 10.1007/S00401-011-0826-Y |
0.515 |
|
| 2011 |
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Head E, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801 |
0.688 |
|
| 2011 |
Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 172-80. PMID 21193043 DOI: 10.1016/J.Phrs.2010.12.007 |
0.424 |
|
| 2011 |
Head E, Doran E, Nistor M, Hill M, Schmitt FA, Haier RJ, Lott IT. Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome. Journal of Alzheimer's Disease : Jad. 23: 399-409. PMID 21116050 DOI: 10.3233/Jad-2010-101335 |
0.372 |
|
| 2011 |
Head E. Neurobiology of the aging dog. Age (Dordrecht, Netherlands). 33: 485-96. PMID 20845082 DOI: 10.1007/s11357-010-9183-3 |
0.5 |
|
| 2011 |
Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiology of Aging. 32: 604-13. PMID 19428144 DOI: 10.1016/J.Neurobiolaging.2009.04.008 |
0.33 |
|
| 2011 |
Murphy M, Morales J, Beckett T, Astarita G, Piomelli D, Weidner A, Studzinski C, Dowling A, Wang X, LeVine H, Kryscio R, Lin Y, Barrett E, Head E. Erratum: Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs (Journal of Alzheimer's Disease (2010) 22:1 (135-150) DOI: 10.3233/JAD-2010-100639) Journal of Alzheimer's Disease. 24: 837. DOI: 10.3233/Jad-2011-111438 |
0.355 |
|
| 2011 |
Cotman CW, Head E. The canine model of human aging and disease Advances in Alzheimer's Disease. 1: 15-38. DOI: 10.3233/978-1-60750-733-8-15 |
0.545 |
|
| 2010 |
Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Molecular Neurodegeneration. 5: 57. PMID 21144050 DOI: 10.1186/1750-1326-5-57 |
0.334 |
|
| 2010 |
Vasilevko V, Passos GF, Quiring D, Head E, Kim RC, Fisher M, Cribbs DH. Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy. Annals of the New York Academy of Sciences. 1207: 58-70. PMID 20955427 DOI: 10.1111/j.1749-6632.2010.05786.x |
0.446 |
|
| 2010 |
Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's Disease : Jad. 22: 135-50. PMID 20847439 DOI: 10.3233/Jad-2010-100639 |
0.806 |
|
| 2010 |
Astarita G, Jung KM, Berchtold NC, Nguyen VQ, Gillen DL, Head E, Cotman CW, Piomelli D. Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. Plos One. 5: e12538. PMID 20838618 DOI: 10.1371/Journal.Pone.0012538 |
0.759 |
|
| 2010 |
Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9831-9. PMID 20660265 DOI: 10.1523/Jneurosci.6194-09.2010 |
0.819 |
|
| 2010 |
Coskun PE, Wyrembak J, Derbereva O, Melkonian G, Doran E, Lott IT, Head E, Cotman CW, Wallace DC. Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia. Journal of Alzheimer's Disease : Jad. 20: S293-310. PMID 20463402 DOI: 10.3233/JAD-2010-100351 |
0.652 |
|
| 2010 |
Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiology of Disease. 39: 301-10. PMID 20451612 DOI: 10.1016/j.nbd.2010.04.014 |
0.735 |
|
| 2010 |
Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/Jad-2010-1397 |
0.831 |
|
| 2010 |
Christie L, Opii W, Head E, Araujo J, De Rivera C, Milgram N, Cotman C. Effects of acetyl-L-carnitine and Lipoic Acid supplementation on cognition in aged beagles Journal of Veterinary Behavior. 5: 160. DOI: 10.1016/j.jveb.2009.12.006 |
0.584 |
|
| 2010 |
Head E, Dowling ALS, Barrett EG, Blalock EM. Gene expression changes as a function of age in beagles: preliminary results Journal of Veterinary Behavior-Clinical Applications and Research. 5: 161. DOI: 10.1016/J.Jveb.2009.12.003 |
0.303 |
|
| 2010 |
Blalock EM, Dowling ALS, Martin S, Popovic J, Barrett EG, Head E. Transcriptional profile of the aging canine brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.673 |
0.383 |
|
| 2009 |
Kumasaka DK, Galvan V, Head E, Rohn TT. Caspase cleavage of the amyloid precursor protein is prevented after overexpression of bcl-2 in a triple transgenic mouse model of Alzheimer's disease. International Journal of Physiology, Pathophysiology and Pharmacology. 1: 48-56. PMID 20411026 |
0.301 |
|
| 2009 |
Joseph J, Cole G, Head E, Ingram D. Nutrition, brain aging, and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12795-801. PMID 19828791 DOI: 10.1523/Jneurosci.3520-09.2009 |
0.439 |
|
| 2009 |
Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Experimental Gerontology. 44: 752-9. PMID 19735717 DOI: 10.1016/J.Exger.2009.08.012 |
0.623 |
|
| 2009 |
Christie LA, Opii WO, Head E. Strategies for improving cognition with aging: insights from a longitudinal study of antioxidant and behavioral enrichment in canines. Age (Dordrecht, Netherlands). 31: 211-20. PMID 19714491 DOI: 10.1007/s11357-008-9063-2 |
0.423 |
|
| 2009 |
Head E, Nukala VN, Fenoglio KA, Muggenburg BA, Cotman CW, Sullivan PG. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Experimental Neurology. 220: 171-6. PMID 19703441 DOI: 10.1016/J.Expneurol.2009.08.014 |
0.612 |
|
| 2009 |
Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiology of Disease. 35: 352-8. PMID 19523517 DOI: 10.1016/j.nbd.2009.05.024 |
0.494 |
|
| 2009 |
Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathologica. 118: 505-17. PMID 19360426 DOI: 10.1007/S00401-009-0530-3 |
0.501 |
|
| 2009 |
Vasilevko V, Head E. Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle. Cns & Neurological Disorders Drug Targets. 8: 98-113. PMID 19355931 DOI: 10.2174/187152709787847333 |
0.505 |
|
| 2009 |
Berlau DJ, Corrada MM, Head E, Kawas CH. APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old. Neurology. 72: 829-34. PMID 19255410 DOI: 10.1212/01.Wnl.0000343853.00346.A4 |
0.426 |
|
| 2009 |
Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. The Journal of Biological Chemistry. 284: 4230-7. PMID 19098006 DOI: 10.1074/Jbc.M808591200 |
0.363 |
|
| 2009 |
Head E. Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging. Neurochemical Research. 34: 670-8. PMID 18683046 DOI: 10.1007/s11064-008-9808-4 |
0.501 |
|
| 2009 |
Head E, Corrada MM, Kahle-Wrobleski K, Kim RC, Sarsoza F, Goodus M, Kawas CH. Synaptic proteins, neuropathology and cognitive status in the oldest-old. Neurobiology of Aging. 30: 1125-34. PMID 18006193 DOI: 10.1016/J.Neurobiolaging.2007.10.001 |
0.802 |
|
| 2009 |
Astarita G, Head E, Cotman CW, Piomelli D. P3-011: Omega-3 fatty acid deficit in Alzheimer's disease Alzheimer's & Dementia. 5: P343-P343. DOI: 10.1016/j.jalz.2009.04.1188 |
0.562 |
|
| 2008 |
Rohn TT, Head E. Caspase activation in Alzheimer's disease: early to rise and late to bed. Reviews in the Neurosciences. 19: 383-93. PMID 19317178 DOI: 10.1515/Revneuro.2008.19.6.383 |
0.393 |
|
| 2008 |
Cotman CW, Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. Journal of Alzheimer's Disease : Jad. 15: 685-707. PMID 19096165 DOI: 10.3233/Jad-2008-15413 |
0.714 |
|
| 2008 |
Berchtold NC, Cribbs DH, Coleman PD, Rogers J, Head E, Kim R, Beach T, Miller C, Troncoso J, Trojanowski JQ, Zielke HR, Cotman CW. Gene expression changes in the course of normal brain aging are sexually dimorphic. Proceedings of the National Academy of Sciences of the United States of America. 105: 15605-10. PMID 18832152 DOI: 10.1073/Pnas.0806883105 |
0.771 |
|
| 2008 |
Christie LA, Saunders RC, Kowalska DM, MacKay WA, Head E, Cotman CW. Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines. The Journal of Comparative Neurology. 511: 257-70. PMID 18792072 DOI: 10.1002/cne.21821 |
0.534 |
|
| 2008 |
Movsesyan N, Ghochikyan A, Mkrtichyan M, Petrushina I, Davtyan H, Olkhanud PB, Head E, Biragyn A, Cribbs DH, Agadjanyan MG. Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy. Plos One. 3: e2124. PMID 18461171 DOI: 10.1371/Journal.Pone.0002124 |
0.633 |
|
| 2008 |
Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3555-66. PMID 18385314 DOI: 10.1523/JNEUROSCI.0208-08.2008 |
0.736 |
|
| 2008 |
Rohn TT, Vyas V, Hernandez-Estrada T, Nichol KE, Christie LA, Head E. Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3051-9. PMID 18354008 DOI: 10.1523/Jneurosci.5620-07.2008 |
0.444 |
|
| 2008 |
Head E, Rofina J, Zicker S. Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging. The Veterinary Clinics of North America. Small Animal Practice. 38: 167-78, vi. PMID 18249248 DOI: 10.1016/j.cvsm.2007.10.002 |
0.437 |
|
| 2008 |
Haier RJ, Head K, Head E, Lott IT. Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events. Neuroimage. 39: 1324-32. PMID 18006337 DOI: 10.1016/j.neuroimage.2007.09.064 |
0.377 |
|
| 2008 |
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiology of Aging. 29: 39-50. PMID 17092609 DOI: 10.1016/J.Neurobiolaging.2006.09.018 |
0.601 |
|
| 2008 |
Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiology of Aging. 29: 51-70. PMID 17055614 DOI: 10.1016/J.Neurobiolaging.2006.09.012 |
0.647 |
|
| 2008 |
Patel PC, Sarsoza F, Vasilevko V, Pan M-, Tsu W, Constantinescu C, Coleman R, Head E, Mukherjee J. 18F-fluoropropyl curcumin binding to β-amyloid plaques in transgenic mouse model of Alzheimer's disease Neuroimage. 41. DOI: 10.1016/J.Neuroimage.2008.04.083 |
0.337 |
|
| 2008 |
Rohn TT, Kumasaka D, Head E. P1-119: Caspase-cleavage of the amyloid precursor protein is prevented in a triple transgenic mouse model of Alzheimer's disease following overexpression of Bcl-2 Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.706 |
0.378 |
|
| 2008 |
Berlau D, Corrada M, Head E, Kawas C. O4-05-03: The apolipoprotein E-epsilon 2 allele is associated with increased Alzheimer neuropathology but preserved cognition: Findings from the 90+ study Alzheimer's & Dementia. 4: T194-T194. DOI: 10.1016/J.Jalz.2008.05.538 |
0.353 |
|
| 2007 |
Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12721-31. PMID 18003852 DOI: 10.1523/Jneurosci.3201-07.2007 |
0.643 |
|
| 2007 |
Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Molecular Neurodegeneration. 2: 18. PMID 17897471 DOI: 10.1186/1750-1326-2-18 |
0.604 |
|
| 2007 |
Head E. Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging. Annals of the New York Academy of Sciences. 1114: 398-406. PMID 17717087 DOI: 10.1196/annals.1396.004 |
0.475 |
|
| 2007 |
Berlau DJ, Kahle-Wrobleski K, Head E, Goodus M, Kim R, Kawas C. Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Archives of Neurology. 64: 1193-6. PMID 17698712 DOI: 10.1001/Archneur.64.8.1193 |
0.819 |
|
| 2007 |
Gunn-Moore D, Moffat K, Christie LA, Head E. Cognitive dysfunction and the neurobiology of ageing in cats. The Journal of Small Animal Practice. 48: 546-53. PMID 17617164 DOI: 10.1111/j.1748-5827.2007.00386.x |
0.447 |
|
| 2007 |
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiology of Learning and Memory. 88: 249-59. PMID 17587610 DOI: 10.1016/J.Nlm.2007.05.001 |
0.633 |
|
| 2007 |
Head E, Lott IT, Patterson D, Doran E, Haier RJ. Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention. Journal of Alzheimer's Disease : Jad. 11: 61-76. PMID 17361036 DOI: 10.3233/Jad-2007-11110 |
0.499 |
|
| 2007 |
Nistor M, Don M, Parekh M, Sarsoza F, Goodus M, Lopez GE, Kawas C, Leverenz J, Doran E, Lott IT, Hill M, Head E. Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiology of Aging. 28: 1493-506. PMID 16904243 DOI: 10.1016/J.Neurobiolaging.2006.06.023 |
0.814 |
|
| 2007 |
Coskun PE, Derbeneva O, Head E, Procaccio V, Lott IT, Wallace DC. 77 Somatic mtDNA control region mutations and their effects in down syndrome with Alzheimer dementia Mitochondrion. 7: 426. DOI: 10.1016/J.Mito.2007.08.081 |
0.323 |
|
| 2007 |
Mukherjee J, Head E, Pichika R, Easwaramoorthy B, Collins D, Chen I, Wang CS, Saigal N, Trinidad P, Kim K, Nguyen VL. Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease Journal of Labelled Compounds and Radiopharmaceuticals. 50: 375-379. DOI: 10.1002/jlcr.1266 |
0.386 |
|
| 2006 |
Lott IT, Head E, Doran E, Busciglio J. Beta-amyloid, oxidative stress and down syndrome. Current Alzheimer Research. 3: 521-8. PMID 17168651 DOI: 10.2174/156720506779025305 |
0.439 |
|
| 2006 |
Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Research Reviews. 5: 354-69. PMID 16949888 DOI: 10.1016/J.Arr.2006.04.004 |
0.399 |
|
| 2006 |
Head E, Starr A, Kim RC, Parachikova A, Lopez GE, Dick M, Cribbs DH. Relapsing polychondritis with features of dementia with Lewy bodies. Acta Neuropathologica. 112: 217-25. PMID 16832629 DOI: 10.1007/S00401-006-0098-0 |
0.786 |
|
| 2006 |
Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiology of Learning and Memory. 86: 197-204. PMID 16616528 DOI: 10.1016/J.Nlm.2006.02.005 |
0.836 |
|
| 2006 |
Gunn-Moore DA, McVee J, Bradshaw JM, Pearson GR, Head E, Gunn-Moore FJ. Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits. Journal of Feline Medicine and Surgery. 8: 234-42. PMID 16603401 DOI: 10.1016/j.jfms.2006.01.003 |
0.496 |
|
| 2006 |
Mouser PE, Head E, Ha KH, Rohn TT. Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain. The American Journal of Pathology. 168: 936-46. PMID 16507909 DOI: 10.2353/ajpath.2006.050798 |
0.399 |
|
| 2006 |
Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/J.Vaccine.2005.12.058 |
0.609 |
|
| 2006 |
Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 29: 234-44. PMID 16275022 DOI: 10.1016/J.Neuroimage.2005.07.043 |
0.425 |
|
| 2006 |
Chubb C, Inagaki Y, Sheu P, Cummings B, Wasserman A, Head E, Cotman C. BioVision: an application for the automated image analysis of histological sections. Neurobiology of Aging. 27: 1462-76. PMID 16271803 DOI: 10.1016/J.Neurobiolaging.2005.08.023 |
0.584 |
|
| 2006 |
Buttini M, Chen M, Head E, Cotman C, Games D. O1-01-04: Inflammatory cell infiltrates are commonly associated with brain vasculature and cerebral amyloid angiopathy in Alzheimer's disease Alzheimer's & Dementia. 2: S8-S9. DOI: 10.1016/j.jalz.2006.05.037 |
0.605 |
|
| 2005 |
Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordrecht, Netherlands). 27: 27-37. PMID 23598601 DOI: 10.1007/S11357-005-4001-Z |
0.825 |
|
| 2005 |
Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. Journal of the American Veterinary Medical Association. 227: 722-8. PMID 16178393 DOI: 10.2460/Javma.2005.227.722 |
0.597 |
|
| 2005 |
Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathologica. 110: 135-44. PMID 15986225 DOI: 10.1007/S00401-005-1027-3 |
0.722 |
|
| 2005 |
Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 461-9. PMID 15795055 DOI: 10.1016/J.Pnpbp.2004.12.011 |
0.627 |
|
| 2005 |
Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 443-53. PMID 15795053 DOI: 10.1016/J.Pnpbp.2004.12.009 |
0.44 |
|
| 2005 |
Tapp PD, Chu Y, Araujo JA, Chiou JY, Head E, Milgram NW, Su MY. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 399-406. PMID 15795048 DOI: 10.1016/J.Pnpbp.2004.12.006 |
0.375 |
|
| 2005 |
Su MY, Tapp PD, Vu L, Chen YF, Chu Y, Muggenburg B, Chiou JY, Chen C, Wang J, Bracco C, Head E. A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 389-97. PMID 15795047 DOI: 10.1016/J.Pnpbp.2004.12.005 |
0.374 |
|
| 2005 |
Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 361-9. PMID 15795044 DOI: 10.1016/J.Pnpbp.2004.12.002 |
0.776 |
|
| 2005 |
Helguera P, Pelsman A, Pigino G, Wolvetang E, Head E, Busciglio J. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2295-303. PMID 15745955 DOI: 10.1523/Jneurosci.5107-04.2005 |
0.352 |
|
| 2005 |
Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging. 26: 749-63. PMID 15708450 DOI: 10.1016/J.Neurobiolaging.2004.06.015 |
0.791 |
|
| 2005 |
Thomas SN, Soreghan BA, Nistor M, Sarsoza F, Head E, Yang AJ. Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach. Journal of Neurochemistry. 92: 705-17. PMID 15686472 DOI: 10.1111/J.1471-4159.2004.02892.X |
0.421 |
|
| 2005 |
Lott IT, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiology of Aging. 26: 383-9. PMID 15639317 DOI: 10.1016/j.neurobiolaging.2004.08.005 |
0.387 |
|
| 2005 |
Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiology of Aging. 26: 77-90. PMID 15585348 DOI: 10.1016/J.Neurobiolaging.2004.02.014 |
0.59 |
|
| 2005 |
Head E, Cotman CW, Zicker SC, Milgram NW. The use of dietary antioxidants and mitochondrial co-factors to promote successful aging Current Topics in Nutraceutical Research. 3: 85-94. |
0.503 |
|
| 2004 |
Liu J, Head E, Kuratsune H, Cotman CW, Ames BN. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Annals of the New York Academy of Sciences. 1033: 117-31. PMID 15591009 DOI: 10.1196/Annals.1320.011 |
0.54 |
|
| 2004 |
Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8205-13. PMID 15385603 DOI: 10.1523/Jneurosci.1339-04.2004 |
0.653 |
|
| 2004 |
Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behavioural Brain Research. 153: 199-210. PMID 15219721 DOI: 10.1016/J.Bbr.2003.12.003 |
0.57 |
|
| 2004 |
Johnson JK, Vogt BA, Kim R, Cotman CW, Head E. Isolated executive impairment and associated frontal neuropathology. Dementia and Geriatric Cognitive Disorders. 17: 360-7. PMID 15178954 DOI: 10.1159/000078183 |
0.642 |
|
| 2004 |
Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology. 39: 753-65. PMID 15130670 DOI: 10.1016/J.Exger.2004.01.007 |
0.588 |
|
| 2004 |
Head E, Zicker SC. Nutraceuticals, aging, and cognitive dysfunction. The Veterinary Clinics of North America. Small Animal Practice. 34: 217-28. PMID 15032129 DOI: 10.1016/J.Cvsm.2003.09.007 |
0.436 |
|
| 2004 |
Head E, Lott IT. Down syndrome and beta-amyloid deposition. Current Opinion in Neurology. 17: 95-100. PMID 15021233 DOI: 10.1097/00019052-200404000-00003 |
0.37 |
|
| 2004 |
Moore P, Dennis K, DeVita C, Grossman M, Lebert F, Stekke W, Hasenbroekx C, Pasquier F, Johnson JK, Vogt BA, Kim R, Cotman CW, Head E, Comstock H, Pickering-Brown S, et al. Contents Vol. 17, 2004 Dementia and Geriatric Cognitive Disorders. 17: 387-389. DOI: 10.1159/000078837 |
0.481 |
|
| 2004 |
Moore P, Dennis K, DeVita C, Grossman M, Lebert F, Stekke W, Hasenbroekx C, Pasquier F, Johnson JK, Vogt BA, Kim R, Cotman CW, Head E, Comstock H, Pickering-Brown S, et al. Subject Index Vol. 17, 2004 Dementia and Geriatric Cognitive Disorders. 17: 384-385. DOI: 10.1159/000078836 |
0.484 |
|
| 2004 |
Rohn TT, Newman J, Sarsoza F, Kim RC, Dick M, Head E. P3-212 Caspase-cleaved tau accumulation in Pick's disease, Lewy body disease and frontotemporal dementia Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81362-9 |
0.334 |
|
| 2004 |
Tapp D, Siwak CT, Gao FQ, Chiou J, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su M. P3-066 Changes in frontal lobe volume, executive function, and amyloid load in a canine model of aging Neurobiology of Aging. 25: S371. DOI: 10.1016/S0197-4580(04)81218-1 |
0.602 |
|
| 2004 |
Head E, Moffatt K, Das P, Sarsoza F, Landsberg GM, Lott IT, Murphy MP. P2-008 β-Amyloid accumulation and tau phosphorylation in the aged cat brain: comparison with Alzheimer's disease and Down syndrome Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80756-5 |
0.443 |
|
| 2003 |
Haier RJ, Alkire MT, White NS, Uncapher MR, Head E, Lott IT, Cotman CW. Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia. Neurology. 61: 1673-9. PMID 14694028 DOI: 10.1212/01.Wnl.0000098935.36984.25 |
0.644 |
|
| 2003 |
Zhao M, Su J, Head E, Cotman CW. Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease. Neurobiology of Disease. 14: 391-403. PMID 14678756 DOI: 10.1016/j.nbd.2003.07.006 |
0.645 |
|
| 2003 |
Ghochikyan A, Vasilevko V, Petrushina I, Movsesyan N, Babikyan D, Tian W, Sadzikava N, Ross TM, Head E, Cribbs DH, Agadjanyan MG. Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene. European Journal of Immunology. 33: 3232-41. PMID 14635031 DOI: 10.1002/eji.200324000 |
0.363 |
|
| 2003 |
Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behavioral Neuroscience. 117: 1066-75. PMID 14570555 DOI: 10.1037/0735-7044.117.5.1066 |
0.611 |
|
| 2003 |
Head E, Lott IT, Hof PR, Bouras C, Su JH, Kim R, Haier R, Cotman CW. Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome. Journal of Neuropathology and Experimental Neurology. 62: 917-26. PMID 14533781 DOI: 10.1093/Jnen/62.9.917 |
0.655 |
|
| 2003 |
Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behavioral Neuroscience. 117: 813-24. PMID 12931965 DOI: 10.1037/0735-7044.117.4.813 |
0.608 |
|
| 2003 |
Bi X, Head E, Cotman CW, Lynch G. Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease. The Journal of Comparative Neurology. 464: 371-81. PMID 12900930 DOI: 10.1002/cne.10795 |
0.662 |
|
| 2003 |
Torp R, Ottersen OP, Cotman CW, Head E. Identification of neuronal plasma membrane microdomains that colocalize beta-amyloid and presenilin: implications for beta-amyloid precursor protein processing. Neuroscience. 120: 291-300. PMID 12890502 DOI: 10.1016/S0306-4522(03)00320-8 |
0.636 |
|
| 2003 |
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (New York, N.Y.). 300: 486-9. PMID 12702875 DOI: 10.1126/Science.1079469 |
0.63 |
|
| 2003 |
Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning & Memory (Cold Spring Harbor, N.Y.). 10: 64-73. PMID 12551965 DOI: 10.1101/Lm.54403 |
0.617 |
|
| 2003 |
Head E, Milgram NW, Cotman CW. Neuropathology in ageing dogs | Neuropathologische Veränderungen bei alternden Hunden Praktische Tierarzt. 84: 192-195. |
0.569 |
|
| 2002 |
Rohn TT, Rissman RA, Head E, Cotman CW. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News & Perspectives. 15: 549-557. PMID 12677194 DOI: 10.1358/dnp.2002.15.9.740233 |
0.715 |
|
| 2002 |
Rohn TT, Rissman RA, Davis MC, Kim YE, Cotman CW, Head E. Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain. Neurobiology of Disease. 11: 341-54. PMID 12505426 DOI: 10.1006/nbdi.2002.0549 |
0.717 |
|
| 2002 |
Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL, Vinters HV, Head E, Perry G, Lamanna JC, Friedland RP, Cotman CW. Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Annals of the New York Academy of Sciences. 977: 45-64. PMID 12480733 DOI: 10.1111/J.1749-6632.2002.Tb04798.X |
0.624 |
|
| 2002 |
Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neuroscience and Biobehavioral Reviews. 26: 679-95. PMID 12479842 DOI: 10.1016/S0149-7634(02)00039-8 |
0.597 |
|
| 2002 |
Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiology of Aging. 23: 809-18. PMID 12392784 DOI: 10.1016/S0197-4580(02)00073-8 |
0.684 |
|
| 2002 |
Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiology of Aging. 23: 737-45. PMID 12392778 DOI: 10.1016/S0197-4580(02)00020-9 |
0.626 |
|
| 2002 |
Head E, Lott IT, Cribbs DH, Cotman CW, Rohn TT. Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome. Neuroscience Letters. 330: 99-103. PMID 12213643 DOI: 10.1016/S0304-3940(02)00705-X |
0.622 |
|
| 2002 |
Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. Oxidative damage increases with age in a canine model of human brain aging. Journal of Neurochemistry. 82: 375-81. PMID 12124438 DOI: 10.1046/J.1471-4159.2002.00969.X |
0.652 |
|
| 2002 |
Su JH, Kesslak JP, Head E, Cotman CW. Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain. Acta Neuropathologica. 104: 1-6. PMID 12070657 DOI: 10.1007/s00401-002-0548-2 |
0.611 |
|
| 2002 |
Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behavioral Neuroscience. 116: 443-54. PMID 12049325 DOI: 10.1037/0735-7044.116.3.443 |
0.607 |
|
| 2002 |
Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 99: 2356-61. PMID 11854529 DOI: 10.1073/Pnas.261709299 |
0.57 |
|
| 2002 |
Head E, Torp R. Insights into Abeta and presenilin from a canine model of human brain aging. Neurobiology of Disease. 9: 1-10. PMID 11848680 DOI: 10.1006/nbdi.2002.0476 |
0.484 |
|
| 2001 |
Head E. Brain aging in dogs: parallels with human brain aging and Alzheimer's disease. Veterinary Therapeutics : Research in Applied Veterinary Medicine. 2: 247-60. PMID 19746668 |
0.35 |
|
| 2001 |
Rohn TT, Head E, Nesse WH, Cotman CW, Cribbs DH. Activation of caspase-8 in the Alzheimer's disease brain. Neurobiology of Disease. 8: 1006-16. PMID 11741396 DOI: 10.1006/Nbdi.2001.0449 |
0.603 |
|
| 2001 |
Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiology of Disease. 8: 792-806. PMID 11592849 DOI: 10.1006/nbdi.2001.0431 |
0.642 |
|
| 2001 |
Lott IT, Head E. Down syndrome and Alzheimer's disease: a link between development and aging. Mental Retardation and Developmental Disabilities Research Reviews. 7: 172-8. PMID 11553933 DOI: 10.1002/mrdd.1025 |
0.484 |
|
| 2001 |
Head E, Azizeh BY, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome. Neurobiology of Disease. 8: 252-65. PMID 11300721 DOI: 10.1006/Nbdi.2000.0380 |
0.669 |
|
| 2001 |
Rohn TT, Head E, Su JH, Anderson AJ, Bahr BA, Cotman CW, Cribbs DH. Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease. The American Journal of Pathology. 158: 189-98. PMID 11141492 DOI: 10.1016/S0002-9440(10)63957-0 |
0.735 |
|
| 2000 |
Torp R, Head E, Cotman CW. Ultrastructural analyses of beta-amyloid in the aged dog brain: neuronal beta-amyloid is localized to the plasma membrane. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 801-10. PMID 11191714 DOI: 10.1016/S0278-5846(00)00107-X |
0.625 |
|
| 2000 |
Head E, Thornton PL, Tong L, Cotman CW. Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 777-86. PMID 11191712 DOI: 10.1016/S0278-5846(00)00105-6 |
0.639 |
|
| 2000 |
Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. Development of a protocol for studying object recognition memory in the dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 693-707. PMID 11191709 DOI: 10.1016/S0278-5846(00)00102-0 |
0.529 |
|
| 2000 |
Head E, Cotman CW, Milgram NW. Canine cognition, aging and neuropathology. Introduction. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 671-3. PMID 11191707 DOI: 10.1016/S0278-5846(00)00100-7 |
0.624 |
|
| 2000 |
Johnson JK, Head E, Kim R, Starr A, Cotman CW. Topography, histology, and seminology in dementia Archives of Neurology. 57: 899-900. PMID 10867791 DOI: 10.1001/Archneur.57.6.899 |
0.57 |
|
| 2000 |
Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiology of Aging. 21: 89-96. PMID 10794853 DOI: 10.1016/S0197-4580(00)00093-2 |
0.654 |
|
| 2000 |
Azizeh BY, Head E, Ibrahim MA, Torp R, Tenner AJ, Kim RC, Lott IT, Cotman CW. Molecular dating of senile plaques in the brains of individuals with Down syndrome and in aged dogs. Experimental Neurology. 163: 111-22. PMID 10785449 DOI: 10.1006/Exnr.2000.7359 |
0.669 |
|
| 2000 |
Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 96: 495-506. PMID 10717430 DOI: 10.1016/S0306-4522(99)00568-0 |
0.606 |
|
| 2000 |
Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behavioural Brain Research. 108: 47-56. PMID 10680756 DOI: 10.1016/S0166-4328(99)00132-1 |
0.607 |
|
| 2000 |
Torp R, Azizeh BY, Head E, Cotman C. 5. Molecular dating of senile plaques in the brains of individuals with Down syndrome. Acta Neurologica Scandinavica. 102: 5-52. DOI: 10.1034/j.1600-0404.2000.00202-31.x |
0.575 |
|
| 2000 |
Head E, Azizeh BY, Wong SM, Lott IT, Tenner AJ, Cotman CW, Cribbs DH. C1Q and inflammation in Down syndrome pathogenesis Neurobiology of Aging. 21: 12. DOI: 10.1016/S0197-4580(00)82731-1 |
0.503 |
|
| 1999 |
Johnson JK, Head E, Kim R, Starr A, Cotman CW. Clinical and pathological evidence for a frontal variant of Alzheimer disease. Archives of Neurology. 56: 1233-9. PMID 10520939 DOI: 10.1001/Archneur.56.10.1233 |
0.622 |
|
| 1999 |
Fonseca MI, Head E, Velazquez P, Cotman CW, Tenner AJ. The presence of isoaspartic acid in beta-amyloid plaques indicates plaque age. Experimental Neurology. 157: 277-88. PMID 10364440 DOI: 10.1006/Exnr.1999.7058 |
0.656 |
|
| 1999 |
Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Landmark discrimination learning in the dog. Learning & Memory (Cold Spring Harbor, N.Y.). 6: 54-61. PMID 10355524 DOI: 10.1101/Lm.6.1.54 |
0.54 |
|
| 1998 |
Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O. Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiology of Aging. 19: 479-85. PMID 9880050 DOI: 10.1016/S0197-4580(98)00081-5 |
0.631 |
|
| 1998 |
Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiology of Aging. 19: 415-25. PMID 9880044 DOI: 10.1016/S0197-4580(98)00084-0 |
0.626 |
|
| 1998 |
Ruehl WW, Neilson J, Hart B, Head E, Bruyette DS, Cummings BJ. Therapeutic actions of L-deprenyl in dogs: a model of human brain aging. Advances in Pharmacology (San Diego, Calif.). 42: 316-9. PMID 9327904 DOI: 10.1016/S1054-3589(08)60753-X |
0.51 |
|
| 1997 |
Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Research. 774: 35-43. PMID 9452189 DOI: 10.1016/S0006-8993(97)81684-8 |
0.722 |
|
| 1997 |
Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Open field activity and human interaction as a function of age and breed in dogs. Physiology & Behavior. 62: 963-71. PMID 9333188 DOI: 10.1016/S0031-9384(97)00198-4 |
0.602 |
|
| 1996 |
Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640 DOI: 10.1016/0197-4580(96)00062-0 |
0.571 |
|
| 1996 |
Head E, Hartley J, Kameka AM, Mehta R, Ivy GO, Ruehl WW, Milgram NW. The effects of L-deprenyl on spatial short term memory in young and aged dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 20: 515-30. PMID 8771606 DOI: 10.1016/0278-5846(96)00014-0 |
0.307 |
|
| 1996 |
Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiology of Aging. 17: 259-68. PMID 8744407 DOI: 10.1016/0197-4580(95)02060-8 |
0.694 |
|
| 1996 |
Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiology of Learning and Memory. 66: 11-23. PMID 8661247 DOI: 10.1006/Nlme.1996.0039 |
0.649 |
|
| 1995 |
Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Progress in Brain Research. 106: 217-25. PMID 8584657 DOI: 10.1016/S0079-6123(08)61218-2 |
0.644 |
|
| 1995 |
Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. Spatial learning and memory as a function of age in the dog. Behavioral Neuroscience. 109: 851-8. PMID 8554710 DOI: 10.1037//0735-7044.109.5.851 |
0.602 |
|
| 1994 |
Milgram NW, Head E, Weiner E, Thomas E. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behavioral Neuroscience. 108: 57-68. PMID 8192851 DOI: 10.1037//0735-7044.108.1.57 |
0.383 |
|
| 1994 |
Carrillo MC, Ivy GO, Milgram NW, Head E, Wu P, Kitani K. (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Life Sciences. 54: 1483-9. PMID 8190023 DOI: 10.1016/0024-3205(94)90015-9 |
0.304 |
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