Siddharthan Chandran - Publications

Affiliations: 
Centre for Brain Reparir, University of Cambridge, UK, Cambridge, England, United Kingdom 
Area:
Neural Stem Cell biology
Website:
http://www.brc.cam.ac.uk/SiddharthanChandran.htm

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 James OG, Selvaraj BT, Magnani D, Burr K, Connick P, Barton SK, Vasistha NA, Hampton DW, Story D, Smigiel R, Ploski R, Brophy PJ, Ffrench-Constant C, Lyons DA, Chandran S. iPSC-derived myelinoids to study myelin biology of humans. Developmental Cell. 57: 146. PMID 35016003 DOI: 10.1016/j.devcel.2021.12.009  0.725
2021 Barton SK, Magnani D, James OG, Livesey MR, Selvaraj BT, James OT, Perkins EM, Gregory JM, Cleary E, Ausems CRM, Carter RNC, Vasistha NA, Zhao C, Burr K, Story D, ... ... Chandran S, et al. Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model. Brain Communications. 3: fcab255. PMID 35350711 DOI: 10.1093/braincomms/fcab255  0.745
2021 James OG, Selvaraj BT, Magnani D, Burr K, Connick P, Barton SK, Vasistha NA, Hampton DW, Story D, Smigiel R, Ploski R, Brophy PJ, Ffrench-Constant C, Lyons DA, Chandran S. iPSC-derived myelinoids to study myelin biology of humans. Developmental Cell. 56: 1346-1358.e6. PMID 33945785 DOI: 10.1016/j.devcel.2021.04.006  0.721
2020 Glasmacher SA, Larraz J, Mehta AR, Kearns PKA, Wong M, Newton J, Davenport R, Gorrie G, Morrison I, Carod Artal J, Chandran S, Pal S. The immediate impact of the COVID-19 pandemic on motor neuron disease services and mortality in Scotland. Journal of Neurology. PMID 32889618 DOI: 10.1007/s00415-020-10207-9  0.309
2020 Ng Kee Kwong KC, Mehta AR, Nedergaard M, Chandran S. Defining novel functions for cerebrospinal fluid in ALS pathophysiology. Acta Neuropathologica Communications. 8: 140. PMID 32819425 DOI: 10.1186/s40478-020-01018-0  0.309
2020 Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus J, Shi J, Heckman M, Spiegel M, Cook C, Song Y, Yue M, Daughrity L, Carlomagno Y, Jansen-West K, ... ... Chandran S, et al. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of Clinical Investigation. PMID 32790644 DOI: 10.1172/Jci139741  0.338
2020 Newton J, Jayaprakash K, Glasmacher SA, McEleney A, Bethell A, Fraser E, Hatrick J, Haagenrud H, Stott G, Dakin R, Chandran S, Pal S. Excellent reliability of the ALSFRS-R administered via videoconferencing: A study of people with motor neuron disease in Scotland. Journal of the Neurological Sciences. 416: 116991. PMID 32599295 DOI: 10.1016/j.jns.2020.116991  0.319
2020 Licht-Mayer S, Campbell GR, Canizares M, Mehta AR, Gane AB, McGill K, Ghosh A, Fullerton A, Menezes N, Dean J, Dunham J, Al-Azki S, Pryce G, Zandee S, Zhao C, ... ... Chandran S, et al. Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis. Acta Neuropathologica. PMID 32572598 DOI: 10.1007/S00401-020-02179-X  0.322
2020 Das Sharma S, Pal R, Reddy BK, Selvaraj BT, Raj N, Samaga KK, Srinivasan DJ, Ornelas L, Sareen D, Livesey MR, Bassell GJ, Svendsen CN, Kind PC, Chandran S, Chattarji S, et al. Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns. Molecular Autism. 11: 52. PMID 32560741 DOI: 10.1186/S13229-020-00351-4  0.408
2020 Toombs J, Panther L, Ornelas L, Liu C, Gomez E, Martín-Ibáñez R, Cox SR, Ritchie SJ, Harris SE, Taylor A, Redmond P, Russ TC, Murphy L, Cooper JD, Burr K, ... ... Chandran S, et al. Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936. Stem Cell Research. 46: 101851. PMID 32450543 DOI: 10.1016/J.Scr.2020.101851  0.313
2020 Qiu J, Dando O, Febery JA, Fowler JH, Chandran S, Hardingham GE. Neuronal Activity and Its Role in Controlling Antioxidant Genes. International Journal of Molecular Sciences. 21. PMID 32178355 DOI: 10.3390/Ijms21061933  0.33
2020 Gregory JM, McDade K, Livesey MR, Croy I, Marion de Proce S, Aitman T, Chandran S, Smith C. Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis. Neuropathology and Applied Neurobiology. PMID 31925813 DOI: 10.1111/Nan.12597  0.38
2019 Zhao C, Devlin AC, Chouhan AK, Selvaraj BT, Stavrou M, Burr K, Brivio V, He X, Mehta AR, Story D, Shaw CE, Dando O, Hardingham GE, Miles GB, Chandran S. Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology. Glia. PMID 31841614 DOI: 10.1002/Glia.23761  0.789
2019 Nishri Y, Hampton D, Ben-Shushan E, Fainstein N, Magnani D, Aharonowiz M, Reubinoff BE, Chandran S, Ben-Hur T. Continuous Immune-Modulatory Effects of Human Olig2+ Precursor Cells Attenuating a Chronic-Active Model of Multiple Sclerosis. Molecular Neurobiology. PMID 31656989 DOI: 10.1007/S12035-019-01802-7  0.396
2019 Torvell M, Hampton DW, Connick P, MacLullich AMJ, Cunningham C, Chandran S. A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy. Alzheimer's & Dementia (New York, N. Y.). 5: 579-591. PMID 31650014 DOI: 10.1016/J.Trci.2019.09.001  0.316
2019 Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, ... ... Chandran S, et al. Transplanted t(1;11) patient-derived OPCs form shorter myelin internodes in the hypomyelinated shiverer mice. Molecular Psychiatry. 24: 1567. PMID 31645684 DOI: 10.1038/S41380-019-0543-9  0.709
2019 Gregory JM, Livesey MR, McDade K, Selvaraj BT, Barton SK, Chandran S, Smith C. Dysregulation of AMPA receptor subunit expression in sporadic ALS post-mortem brain. The Journal of Pathology. PMID 31579943 DOI: 10.1002/Path.5351  0.404
2019 Vasistha NA, Johnstone M, Barton SK, Mayerl SE, Thangaraj Selvaraj B, Thomson PA, Dando O, Grünewald E, Alloza C, Bastin ME, Livesey MR, Economides K, Magnani D, Makedonopolou P, Burr K, ... ... Chandran S, et al. Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction. Molecular Psychiatry. PMID 31481758 DOI: 10.1038/S41380-019-0505-2  0.739
2019 Gregory JM, Elliot E, McDade K, Bak T, Pal S, Chandran S, Abrahams S, Smith C. Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis. Neuropathology and Applied Neurobiology. PMID 31386770 DOI: 10.1111/Nan.12575  0.342
2019 Barton SK, Gregory JM, Chandran S, Turner BJ. Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS? Frontiers in Molecular Neuroscience. 12: 124. PMID 31164803 DOI: 10.3389/fnmol.2019.00124  0.327
2019 Leighton D, Newton J, Colville S, Bethell A, Craig G, Cunningham L, Flett M, Fraser D, Hatrick J, Lennox H, Marshall L, McAleer D, McEleney A, Millar K, Silver A, ... ... Chandran S, et al. Clinical audit research and evaluation of motor neuron disease (CARE-MND): a national electronic platform for prospective, longitudinal monitoring of MND in Scotland. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-9. PMID 30889975 DOI: 10.1080/21678421.2019.1582673  0.346
2019 Gorrie GH, Chandran S, Colville S, Newton J, Leighton D, Mcdonald M, Pal S, Forbes R, Hair M, Swingler R. Improved survival and 30-day mortality after gastrostomy in Scottish motor neurone disease patients: evidence from a national retrospective cohort study using STROBE criteria. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-7. PMID 30835562 DOI: 10.1080/21678421.2019.1570271  0.318
2019 Magnani D, Chandran S, Wyllie DJA, Livesey MR. In Vitro Generation and Electrophysiological Characterization of OPCs and Oligodendrocytes from Human Pluripotent Stem Cells. Methods in Molecular Biology (Clifton, N.J.). 1936: 65-77. PMID 30820893 DOI: 10.1007/978-1-4939-9072-6_4  0.427
2019 Leighton DJ, Newton J, Stephenson LJ, Colville S, Davenport R, Gorrie G, Morrison I, Swingler R, Chandran S, Pal S. Changing epidemiology of motor neurone disease in Scotland. Journal of Neurology. PMID 30805795 DOI: 10.1007/s00415-019-09190-7  0.322
2019 Mehta A, Selvaraj B, Dando O, Burr K, Hardingham G, Chandran S. 229 Dysregulated axonal homeostasis in C9orf72 iPSC-derived motor neurones Journal of Neurology, Neurosurgery, and Psychiatry. 90. DOI: 10.1136/Jnnp-2019-Abn-2.193  0.329
2019 Leighton D, Newton J, Parry D, Colville S, Swingler R, Porteous M, Aitman T, Gorrie G, Chandran S, Pal S. 15.33 Phenotype-genotype characterisation of ‘long survivors’ with motor neurone disease in Scotland Journal of Neurology, Neurosurgery, and Psychiatry. 90. DOI: 10.1136/Jnnp-2019-Abn-2.15  0.324
2019 Johnstone M, Vasistha N, Barbu M, Dando O, Burr K, Christopher E, Glen S, Johnstone EC, Whalley H, McIntosh A, Lawrie S, Chandran S. 23MODELING A GENETIC RISK FOR SCHIZOPHRENIA: PHENOTYPIC DIFFERENCES IN HUMAN NEURAL PRECURSORS AND CEREBRAL ORGANOIDS FROM PATIENTS WITH CHR16P13.11 MICRODUPLICATIONS European Neuropsychopharmacology. 29: S1079. DOI: 10.1016/J.Euroneuro.2018.08.030  0.721
2019 O'Sullivan S, Bonneau M, Gautier P, Singh Y, Torrance H, McCarthney DL, Volkmer H, Loos M, Evans KL, Semple CA, Chandran S, Didier M, Price DJ, Porteous DJ, Millar JK. 19Transcriptomic Analysis Of Cortical Neurons Derived From Psychiatric Patients Carrying A T(1;11) Translocation, And A Corresponding Mouse Model European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.08.026  0.351
2018 De Sousa PA, Ritchie D, Green A, Chandran S, Knight R, Head MW. Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies. Acta Neuropathologica. PMID 30483944 DOI: 10.1007/s00401-018-1941-9  0.322
2018 Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, ... ... Chandran S, et al. Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging. Molecular Psychiatry. PMID 30401811 DOI: 10.1038/S41380-018-0292-1  0.733
2018 Malavasi ELV, Economides KD, Grünewald E, Makedonopoulou P, Gautier P, Mackie S, Murphy LC, Murdoch H, Crummie D, Ogawa F, McCartney DL, O'Sullivan ST, Burr K, Torrance HS, Phillips J, ... ... Chandran S, et al. DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness. Translational Psychiatry. 8: 184. PMID 30190480 DOI: 10.1038/S41398-018-0228-1  0.353
2018 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Chandran S, et al. Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 9: 16176. PMID 29405195 DOI: 10.1038/Ncomms16176  0.32
2018 Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, ... ... Chandran S, et al. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nature Communications. 9: 347. PMID 29367641 DOI: 10.1038/S41467-017-02729-0  0.759
2017 Henstridge CM, Sideris DI, Carroll E, Rotariu S, Salomonsson S, Tzioras M, McKenzie CA, Smith C, von Arnim CAF, Ludolph AC, Lulé D, Leighton D, Warner J, Cleary E, Newton J, ... ... Chandran S, et al. Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis. Acta Neuropathologica. PMID 29273900 DOI: 10.1007/S00401-017-1797-4  0.306
2017 Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside JW, Head MW, Chandran S. Human stem cell-derived astrocytes replicate human prions in a PRNP genotype-dependent manner. The Journal of Experimental Medicine. PMID 29141869 DOI: 10.1084/Jem.20161547  0.389
2017 Thelin EP, Hall CE, Gupta K, Carpenter K, Chandran S, Hutchinson PJ, Patani R, Helmy A. Elucidating pro-inflammatory cytokine responses following traumatic brain injury in a human stem cell model. Journal of Neurotrauma. PMID 28978285 DOI: 10.1089/Neu.2017.5155  0.332
2017 Al-Chalabi A, Andersen PM, Chandran S, Chio A, Corcia P, Couratier P, Danielsson O, de Carvalho M, Desnuelle C, Grehl T, Grosskreutz J, Holmøy T, Ingre C, Karlsborg M, Kleveland G, et al. July 2017 ENCALS statement on edaravone. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-4. PMID 28975816 DOI: 10.1080/21678421.2017.1369125  0.325
2017 Selvaraj BT, Livesey MR, Chandran S. Modeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells. Brain Pathology (Zurich, Switzerland). 27: 518-524. PMID 28585384 DOI: 10.1111/bpa.12520  0.405
2017 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Chandran S, et al. Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 8: 15132. PMID 28462931 DOI: 10.1038/Ncomms15132  0.359
2017 Chouhan AK, Selvaraj BT, Gane A, Mehta AR, Burr K, Shaw CE, Chandran S, Miles GB. Functional maturity of motor neurons derived from control and ALS patient iPSCs is affected by human iPSC-derived astrocytes F1000research. 6. DOI: 10.7490/F1000Research.1115168.1  0.782
2017 Leighton D, Manson L, McHutchison C, Sherlock L, Newton J, Abrahams S, Chandran S, Pal S. 11 Premorbid neuropsychiatric disease in patients with motor neurone disease in scotland Journal of Neurology, Neurosurgery & Psychiatry. 88: A16.3-A17. DOI: 10.1136/jnnp-2017-BNPA.35  0.322
2017 Gane AB, Selvaraj BT, Chandran S. PO172 The unfolded protein response of ipsc-derived motor neurons in mnd Journal of Neurology, Neurosurgery & Psychiatry. 88: A56.4-A57. DOI: 10.1136/jnnp-2017-ABN.195  0.34
2017 Jiwaji Z, Hasel P, Chandran S, Hardingham G. The role of neuronal activity in regulating metabolism in mouse and human astrocytes The Lancet. 389: S51. DOI: 10.1016/S0140-6736(17)30447-6  0.327
2017 Johnstone M, Vasistha N, Livesey M, Burr K, Whalley H, Clair DS, Blackwood D, Wyllie D, Lawrie S, Johnstone EC, McIntosh AM, Chandran S. Modelling a Genetic Risk for Schizophrenia in Human Induced Pluripotent Stem Cells (Ipscs): Phenotypic Differences in Patients with Mutations in Nde1 European Neuropsychopharmacology. 27: S509-S510. DOI: 10.1016/J.Euroneuro.2016.09.618  0.751
2017 Johnstone M, Vasistha N, Whalley H, Burr K, St. Clair D, Blackwood D, Johnstone E, Lawrie S, McIntosh A, Chandran S. 437. Modeling Schizophrenia in Human Induced Pluripotent Stem Cells (hiPSCs): Phenotypic Differences in Patients with Mutations in NDE1 Biological Psychiatry. 81: S178-S179. DOI: 10.1016/J.Biopsych.2017.02.921  0.744
2017 Alibhai J, Krejciova Z, Ironside J, Manson J, Chandran S, Head M. Establishment of human induced pluripotent stem cell derived astrocytes for modelling human prion disease in vitro Glia. 65. DOI: 10.1002/Glia.23157  0.397
2016 Black HA, Leighton DJ, Cleary EM, Rose E, Stephenson L, Colville S, Ross D, Warner J, Porteous M, Gorrie GH, Swingler R, Goldstein D, Harms MB, Connick P, Pal S, ... ... Chandran S, et al. Genetic epidemiology of motor neuron disease-associated variants in the Scottish population. Neurobiology of Aging. PMID 28089114 DOI: 10.1016/j.neurobiolaging.2016.12.013  0.318
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Chandran S, et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife. 5. PMID 27692071 DOI: 10.7554/Elife.20337  0.404
2016 Alibhai JD, Krejciova Z, Zhao C, Rzechorzek NM, Manson JC, Ironside JW, Chandran S, Head MW. Validating human stem cell derived neural cultures as a flexible model system in which to investigate neurodegenerative mechanisms Prion. 10. PMID 27088811 DOI: 10.1080/19336896.2016.1162644  0.373
2016 Krejciova Z, Alibhai J, Zhao C, Krencik R, Rzechorzek NM, Ullian EM, Manson J, Ironside J, Giles K, Chandran S, Prusiner SB, Head M. Creutzfeldt-Jakob disease prion propagation in human iPS cells-derived astrocytes Prion. 10. PMID 27088809 DOI: 10.1080/19336896.2016.1163103  0.357
2016 Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience. 16: 542-53. PMID 27021939 DOI: 10.1038/nn.4273  0.314
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJ, Hardingham GE, Chandran S. Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. Ebiomedicine. 3: 141-54. PMID 26870825 DOI: 10.1016/J.Ebiom.2015.12.010  0.345
2016 Livesey MR, Magnani D, Cleary EM, Vasistha NA, James OT, Selvaraj BT, Burr K, Story D, Shaw CE, Kind PC, Hardingham GE, Wyllie DJ, Chandran S. Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes. Stem Cells (Dayton, Ohio). PMID 26763608 DOI: 10.1002/Stem.2273  0.77
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Chandran S, et al. Author response: Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Elife. DOI: 10.7554/Elife.20337.021  0.311
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE, Chandran S. Hypothermic modulation of human cortical neurons to explore a role for tau protein in neuroprotection The Lancet. 387: S88. DOI: 10.1016/S0140-6736(16)00475-X  0.367
2015 Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ. Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. The Journal of Physiology. PMID 26608229 DOI: 10.1113/Jp270660  0.44
2015 Rzechorzek NM, Connick P, Patani R, Selvaraj BT, Chandran S. Hypothermic Preconditioning of Human Cortical Neurons Requires Proteostatic Priming. Ebiomedicine. 2: 528-35. PMID 26287272 DOI: 10.1016/j.ebiom.2015.04.004  0.331
2015 Radakovic R, Stephenson L, Colville S, Swingler R, Chandran S, Abrahams S. Multidimensional apathy in ALS: validation of the Dimensional Apathy Scale. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 26203157 DOI: 10.1136/jnnp-2015-310772  0.311
2015 Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, ... ... Chandran S, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066. PMID 25967870 DOI: 10.1038/Ncomms8066  0.346
2015 Gamal W, Borooah S, Smith S, Underwood I, Srsen V, Chandran S, Bagnaninchi PO, Dhillon B. Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes. Biosensors & Bioelectronics. 71: 445-55. PMID 25950942 DOI: 10.1016/J.Bios.2015.04.079  0.319
2015 Devlin AC, Burr K, Borooah S, Foster JD, Cleary EM, Geti I, Vallier L, Shaw CE, Chandran S, Miles GB. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability. Nature Communications. 6: 5999. PMID 25580746 DOI: 10.1038/Ncomms6999  0.696
2014 Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nature Chemical Biology. 10: 677-85. PMID 24974230 DOI: 10.1038/Nchembio.1563  0.413
2014 Nishimura AL, Shum C, Scotter EL, Abdelgany A, Sardone V, Wright J, Lee YB, Chen HJ, Bilican B, Carrasco M, Maniatis T, Chandran S, Rogelj B, Gallo JM, Shaw CE. Allele-specific knockdown of ALS-associated mutant TDP-43 in neural stem cells derived from induced pluripotent stem cells. Plos One. 9: e91269. PMID 24651281 DOI: 10.1371/journal.pone.0091269  0.379
2014 Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4070-5. PMID 24623784 DOI: 10.1523/Jneurosci.5410-13.2014  0.432
2014 Alami NH, Smith RB, Carrasco MA, Williams LA, Winborn CS, Han SS, Kiskinis E, Winborn B, Freibaum BD, Kanagaraj A, Clare AJ, Badders NM, Bilican B, Chaum E, Chandran S, et al. Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations. Neuron. 81: 536-43. PMID 24507191 DOI: 10.1016/J.Neuron.2013.12.018  0.391
2014 Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S. Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. Plos One. 9: e85932. PMID 24465796 DOI: 10.1371/Journal.Pone.0085932  0.404
2014 Stacpoole S, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin R. Functional Human Es-Derived Opcs At Low Oxygen Journal of Neurology, Neurosurgery, and Psychiatry. 85. DOI: 10.1136/Jnnp-2014-309236.149  0.395
2013 Stacpoole SR, Spitzer S, Bilican B, Compston A, Karadottir R, Chandran S, Franklin RJ. High yields of oligodendrocyte lineage cells from human embryonic stem cells at physiological oxygen tensions for evaluation of translational biology. Stem Cell Reports. 1: 437-50. PMID 24286031 DOI: 10.1016/J.Stemcr.2013.09.006  0.399
2013 Bilican B, Serio A, Shaw CE, Maniatis T, Chandran S. Unpicking neurodegeneration in a dish with human pluripotent stem cells: one cell type at a time. Cell Cycle (Georgetown, Tex.). 12: 2339-40. PMID 23856579 DOI: 10.4161/cc.25705  0.493
2013 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Chandran S, et al. Comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188le2. PMID 23740897 DOI: 10.1126/Scitranslmed.3005065  0.398
2013 Reimer MM, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias TB, Kuscha V, Scott AL, Chen YC, Rozov S, Frazer SL, Wyatt C, Higashijima S, Patton EE, Panula P, ... Chandran S, et al. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Developmental Cell. 25: 478-91. PMID 23707737 DOI: 10.1016/j.devcel.2013.04.012  0.332
2013 Hobson EV, McGeachan A, Al-Chalabi A, Chandran S, Crawley F, Dick D, Donaghy C, Ealing J, Ellis CM, Gorrie G, Hanemann CO, Harrower T, Jung A, Majeed T, Malaspina A, et al. Management of sialorrhoea in motor neuron disease: a survey of current UK practice. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 521-7. PMID 23647474 DOI: 10.3109/21678421.2013.790452  0.332
2013 Gupta K, Hardingham GE, Chandran S. NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Neuroscience Letters. 543: 95-100. PMID 23518152 DOI: 10.1016/J.Neulet.2013.03.010  0.405
2013 Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, ... ... Chandran S, et al. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 4697-702. PMID 23401527 DOI: 10.1073/Pnas.1300398110  0.457
2013 Gupta K, Chandran S, Hardingham GE. Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. British Journal of Clinical Pharmacology. 75: 907-18. PMID 23126226 DOI: 10.1111/Bcp.12022  0.436
2013 Ng YS, Moragas M, Chandran S. WASTED AND WEAK ARM IN A YOUNG MAN Journal of Neurology, Neurosurgery & Psychiatry. 84: e2.121-e2. DOI: 10.1136/jnnp-2013-306573.207  0.315
2012 Patani R, Chandran S. Experimental and therapeutic opportunities for stem cells in multiple sclerosis. International Journal of Molecular Sciences. 13: 14470-91. PMID 23203076 DOI: 10.3390/ijms131114470  0.392
2012 Yamazaki T, Chen S, Yu Y, Yan B, Haertlein TC, Carrasco MA, Tapia JC, Zhai B, Das R, Lalancette-Hebert M, Sharma A, Chandran S, Sullivan G, Nishimura AL, Shaw CE, et al. FUS-SMN protein interactions link the motor neuron diseases ALS and SMA. Cell Reports. 2: 799-806. PMID 23022481 DOI: 10.1016/J.Celrep.2012.08.025  0.407
2012 Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry. 122: 738-51. PMID 22681703 DOI: 10.1111/J.1471-4159.2012.07825.X  0.433
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, ... ... Chandran S, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/Pnas.1202922109  0.462
2012 Hampton DW, Innes N, Merkler D, Zhao C, Franklin RJ, Chandran S. Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency. The American Journal of Pathology. 180: 1897-905. PMID 22426338 DOI: 10.1016/J.Ajpath.2012.01.018  0.306
2012 Sajic M, Hunt DP, Lee W, Compston DA, Schweimer JV, Gregson NA, Chandran S, Smith KJ. Mesenchymal stem cells lack efficacy in the treatment of experimental autoimmune neuritis despite in vitro inhibition of T-cell proliferation. Plos One. 7: e30708. PMID 22359549 DOI: 10.1371/Journal.Pone.0030708  0.366
2012 Patani R, Sibley CR, Chandran S, Ule J. Using human pluripotent stem cells to study post-transcriptional mechanisms of neurodegenerative diseases. Brain Research. 1462: 129-38. PMID 22285437 DOI: 10.1016/j.brainres.2011.12.057  0.364
2012 Connick P, Kolappan M, Crawley C, Webber DJ, Patani R, Michell AW, Du MQ, Luan SL, Altmann DR, Thompson AJ, Compston A, Scott MA, Miller DH, Chandran S. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. The Lancet. Neurology. 11: 150-6. PMID 22236384 DOI: 10.1016/S1474-4422(11)70305-2  0.334
2012 Thomson SR, Wishart TM, Patani R, Chandran S, Gillingwater TH. Using induced pluripotent stem cells (iPSC) to model human neuromuscular connectivity: promise or reality? Journal of Anatomy. 220: 122-30. PMID 22133357 DOI: 10.1111/j.1469-7580.2011.01459.x  0.454
2012 Gupta K, Patani R, Baxter P, Serio A, Story D, Tsujita T, Hayes JD, Pedersen RA, Hardingham GE, Chandran S. Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Cell Death and Differentiation. 19: 779-87. PMID 22095276 DOI: 10.1038/Cdd.2011.154  0.427
2012 Bak TH, Chandran S. What wires together dies together: verbs, actions and neurodegeneration in motor neuron disease. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 48: 936-44. PMID 21924711 DOI: 10.1016/j.cortex.2011.07.008  0.312
2011 Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S. Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen. Nature Protocols. 6: 1229-40. PMID 21799491 DOI: 10.1038/Nprot.2011.380  0.385
2011 Ruzov A, Tsenkina Y, Serio A, Dudnakova T, Fletcher J, Bai Y, Chebotareva T, Pells S, Hannoun Z, Sullivan G, Chandran S, Hay DC, Bradley M, Wilmut I, De Sousa P. Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Research. 21: 1332-42. PMID 21747414 DOI: 10.1038/Cr.2011.113  0.367
2011 Connick P, Kolappan M, Patani R, Scott MA, Crawley C, He XL, Richardson K, Barber K, Webber DJ, Wheeler-Kingshott CA, Tozer DJ, Samson RS, Thomas DL, Du MQ, Luan SL, ... ... Chandran S, et al. The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments. Trials. 12: 62. PMID 21366911 DOI: 10.1186/1745-6215-12-62  0.322
2011 Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications. 2: 214. PMID 21364553 DOI: 10.1038/Ncomms1216  0.425
2011 Stacpoole SR, Bilican B, Webber DJ, Luzhynskaya A, He XL, Compston A, Karadottir R, Franklin RJ, Chandran S. Derivation of neural precursor cells from human ES cells at 3% O(2) is efficient, enhances survival and presents no barrier to regional specification and functional differentiation. Cell Death and Differentiation. 18: 1016-23. PMID 21274009 DOI: 10.1038/Cdd.2010.171  0.396
2011 Connick P, Patani R, Chandran S. Stem cells as a resource for regenerative neurology. Practical Neurology. 11: 29-36. PMID 21239652 DOI: 10.1136/jnnp.2010.235184  0.347
2011 Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA. Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death and Differentiation. 18: 907-13. PMID 21212797 DOI: 10.1038/Cdd.2010.169  0.406
2011 Iovino M, Patani R, Chandran S, Spillantini MG. P3-126: Human stem cell-derived neurones as a model to study tau function and dysfunction Alzheimer's & Dementia. 7: S555-S555. DOI: 10.1016/J.Jalz.2011.05.1567  0.409
2010 Iovino M, Patani R, Watts C, Chandran S, Spillantini MG. Human stem cell-derived neurons: a system to study human tau function and dysfunction. Plos One. 5: e13947. PMID 21085657 DOI: 10.1371/Journal.Pone.0013947  0.384
2010 Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S. Cell-mediated neuroprotection in a mouse model of human tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9973-83. PMID 20668182 DOI: 10.1523/Jneurosci.0834-10.2010  0.394
2010 Hardingham GE, Patani R, Baxter P, Wyllie DJ, Chandran S. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Molecular Neurobiology. 42: 97-102. PMID 20431962 DOI: 10.1007/S12035-010-8136-2  0.447
2010 Hunt DP, Sajic M, Phillips H, Henderson D, Compston A, Smith K, Chandran S. Origins of gliogenic stem cell populations within adult skin and bone marrow. Stem Cells and Development. 19: 1055-65. PMID 20102260 DOI: 10.1089/Scd.2009.0371  0.315
2010 Hampton DW, Webber DJ, Bilican B, Goedert M, Spillantini MG, Chandran S. O4-03-08: Cell-mediated Neuroprotection in P301S Human Tau Transgenic Mice, a Model of Human Tauopathy Alzheimer's & Dementia. 6: e17-e18. DOI: 10.1016/J.Jalz.2010.08.053  0.3
2009 Hunt DP, Jahoda C, Chandran S. Multipotent skin-derived precursors: from biology to clinical translation. Current Opinion in Biotechnology. 20: 522-30. PMID 19896826 DOI: 10.1016/j.copbio.2009.10.004  0.359
2009 Patani R, Compston A, Puddifoot CA, Wyllie DJ, Hardingham GE, Allen ND, Chandran S. Activin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity. Plos One. 4: e7327. PMID 19806200 DOI: 10.1371/Journal.Pone.0007327  0.356
2009 Vallier L, Touboul T, Brown S, Cho C, Bilican B, Alexander M, Cedervall J, Chandran S, Ahrlund-Richter L, Weber A, Pedersen RA. Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 27: 2655-66. PMID 19688839 DOI: 10.1002/Stem.199  0.388
2008 Hunt DP, Irvine KA, Webber DJ, Compston DA, Blakemore WF, Chandran S. Effects of direct transplantation of multipotent mesenchymal stromal/stem cells into the demyelinated spinal cord. Cell Transplantation. 17: 865-73. PMID 19044212 DOI: 10.3727/096368908786516738  0.348
2008 Chandran S. What are the prospects of stem cell therapy for neurology? Bmj (Clinical Research Ed.). 337: a1934. PMID 19042937 DOI: 10.1136/Bmj.A1934  0.337
2008 Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S. An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. Journal of Neuroimmunology. 201: 200-11. PMID 18672298 DOI: 10.1016/J.Jneuroim.2008.05.034  0.34
2008 Anderson JM, Hampton DW, Patani R, Pryce G, Crowther RA, Reynolds R, Franklin RJ, Giovannoni G, Compston DA, Baker D, Spillantini MG, Chandran S. Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis. Brain : a Journal of Neurology. 131: 1736-48. PMID 18567922 DOI: 10.1093/Brain/Awn119  0.352
2008 Smith JR, Maguire S, Davis LA, Alexander M, Yang F, Chandran S, ffrench-Constant C, Pedersen RA. Robust, persistent transgene expression in human embryonic stem cells is achieved with AAVS1-targeted integration. Stem Cells (Dayton, Ohio). 26: 496-504. PMID 18024421 DOI: 10.1634/Stemcells.2007-0039  0.321
2008 Joannides AJ, Chandran S. Human embryonic stem cells: an experimental and therapeutic resource for neurological disease. Journal of the Neurological Sciences. 265: 84-8. PMID 17920631 DOI: 10.1016/j.jns.2007.09.008  0.389
2008 Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S. A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells (Dayton, Ohio). 26: 163-72. PMID 17901404 DOI: 10.1634/Stemcells.2007-0281  0.371
2008 Chandran S, Caldwell M, Allen N. Introduction: stem cells and brain repair. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 5-7. PMID 17282994 DOI: 10.1098/rstb.2006.2008  0.35
2008 Chandran S, Hunt D, Joannides A, Zhao C, Compston A, Franklin RJ. Myelin repair: the role of stem and precursor cells in multiple sclerosis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 171-83. PMID 17282989 DOI: 10.1098/Rstb.2006.2019  0.352
2007 Webber DJ, Compston A, Chandran S. Minimally manipulated oligodendrocyte precursor cells retain exclusive commitment to the oligodendrocyte lineage following transplantation into intact and injured hippocampus. The European Journal of Neuroscience. 26: 1791-800. PMID 17897393 DOI: 10.1111/J.1460-9568.2007.05823.X  0.393
2007 Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S. Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells. Brain : a Journal of Neurology. 130: 1263-75. PMID 17472984 DOI: 10.1093/Brain/Awm070  0.405
2007 Joannides AJ, Fiore-Hériché C, Battersby AA, Athauda-Arachchi P, Bouhon IA, Williams L, Westmore K, Kemp PJ, Compston A, Allen ND, Chandran S. A scaleable and defined system for generating neural stem cells from human embryonic stem cells. Stem Cells (Dayton, Ohio). 25: 731-7. PMID 17095704 DOI: 10.1634/Stemcells.2006-0562  0.388
2006 Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND. Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning. Stem Cells (Dayton, Ohio). 24: 1908-13. PMID 16627686 DOI: 10.1634/stemcells.2006-0031  0.384
2006 Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S. Astrocytes promote neurogenesis from oligodendrocyte precursor cells. The European Journal of Neuroscience. 23: 945-56. PMID 16519659 DOI: 10.1111/J.1460-9568.2006.04625.X  0.423
2006 Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston A. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1730-8. PMID 16467521 DOI: 10.1523/Jneurosci.0702-05.2006  0.34
2005 Chandran S, Compston A. Neural stem cells as a potential source of oligodendrocytes for myelin repair. Journal of the Neurological Sciences. 233: 179-81. PMID 15907942 DOI: 10.1016/J.Jns.2005.03.019  0.385
2004 Chandran S, Compston A, Jauniaux E, Gilson J, Blakemore W, Svendsen C. Differential generation of oligodendrocytes from human and rodent embryonic spinal cord neural precursors. Glia. 47: 314-24. PMID 15293229 DOI: 10.1002/Glia.20011  0.35
2004 Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S. Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells. Lancet. 364: 172-8. PMID 15246730 DOI: 10.1016/S0140-6736(04)16630-0  0.389
2003 Joannides A, Gaughwin P, Scott M, Watt S, Compston A, Chandran S. Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells. Journal of Hematotherapy & Stem Cell Research. 12: 681-8. PMID 14977477 DOI: 10.1089/15258160360732704  0.37
2003 Chandran S, Kato H, Gerreli D, Compston A, Svendsen CN, Allen ND. FGF-dependent generation of oligodendrocytes by a hedgehog-independent pathway. Development (Cambridge, England). 130: 6599-609. PMID 14660548 DOI: 10.1242/Dev.00871  0.325
2003 Wilkins A, Majed H, Layfield R, Compston A, Chandran S. Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4967-74. PMID 12832519 DOI: 10.1523/Jneurosci.23-12-04967.2003  0.388
2002 Golde S, Chandran S, Brown GC, Compston A. Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression. Journal of Neurochemistry. 82: 269-82. PMID 12124428 DOI: 10.1046/J.1471-4159.2002.00973.X  0.352
2001 Wilkins A, Chandran S, Compston A. A role for oligodendrocyte-derived IGF-1 in trophic support of cortical neurons. Glia. 36: 48-57. PMID 11571783 DOI: 10.1002/Glia.1094  0.38
1998 Svendsen CN, ter Borg MG, Armstrong RJ, Rosser AE, Chandran S, Ostenfeld T, Caldwell MA. A new method for the rapid and long term growth of human neural precursor cells. Journal of Neuroscience Methods. 85: 141-52. PMID 9874150 DOI: 10.1016/S0165-0270(98)00126-5  0.369
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