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William H. Sheffler, Ph.D. - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
protein structure prediction
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Li Z, Wang S, Nattermann U, Bera AK, Borst AJ, Yaman MY, Bick MJ, Yang EC, Sheffler W, Lee B, Seifert S, Hura GL, Nguyen H, Kang A, Dalal R, et al. Accurate computational design of three-dimensional protein crystals. Nature Materials. PMID 37845322 DOI: 10.1038/s41563-023-01683-1  0.563
2023 Watson JL, Juergens D, Bennett NR, Trippe BL, Yim J, Eisenach HE, Ahern W, Borst AJ, Ragotte RJ, Milles LF, Wicky BIM, Hanikel N, Pellock SJ, Courbet A, Sheffler W, et al. De novo design of protein structure and function with RFdiffusion. Nature. PMID 37433327 DOI: 10.1038/s41586-023-06415-8  0.735
2023 Sheffler W, Yang EC, Dowling Q, Hsia Y, Fries CN, Stanislaw J, Langowski MD, Brandys M, Li Z, Skotheim R, Borst AJ, Khmelinskaia A, King NP, Baker D. Fast and versatile sequence-independent protein docking for nanomaterials design using RPXDock. Plos Computational Biology. 19: e1010680. PMID 37216343 DOI: 10.1371/journal.pcbi.1010680  0.553
2023 Wu K, Bai H, Chang YT, Redler R, McNally KE, Sheffler W, Brunette TJ, Hicks DR, Morgan TE, Stevens TJ, Broerman A, Goreshnik I, DeWitt M, Chow CM, Shen Y, et al. De novo design of modular peptide-binding proteins by superhelical matching. Nature. PMID 37020023 DOI: 10.1038/s41586-023-05909-9  0.388
2023 Wang JYJ, Khmelinskaia A, Sheffler W, Miranda MC, Antanasijevic A, Borst AJ, Torres SV, Shu C, Hsia Y, Nattermann U, Ellis D, Walkey C, Ahlrichs M, Chan S, Kang A, et al. Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proceedings of the National Academy of Sciences of the United States of America. 120: e2214556120. PMID 36888664 DOI: 10.1073/pnas.2214556120  0.414
2022 Said MY, Kang CS, Wang S, Sheffler W, Salveson PJ, Bera AK, Kang A, Nguyen H, Ballard R, Li X, Bai H, Stewart L, Levine P, Baker D. Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks. Chemistry of Materials : a Publication of the American Chemical Society. 34: 9736-9744. PMID 36397834 DOI: 10.1021/acs.chemmater.2c02597  0.747
2021 Hsia Y, Mout R, Sheffler W, Edman NI, Vulovic I, Park YJ, Redler RL, Bick MJ, Bera AK, Courbet A, Kang A, Brunette TJ, Nattermann U, Tsai E, Saleem A, et al. Design of multi-scale protein complexes by hierarchical building block fusion. Nature Communications. 12: 2294. PMID 33863889 DOI: 10.1038/s41467-021-22276-z  0.491
2021 Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, et al. Designed proteins assemble antibodies into modular nanocages. Science (New York, N.Y.). 372. PMID 33795432 DOI: 10.1126/science.abd9994  0.35
2021 Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, et al. Author Correction: Design of biologically active binary protein 2D materials. Nature. PMID 33654323 DOI: 10.1038/s41586-021-03331-7  0.374
2021 Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, et al. Design of biologically active binary protein 2D materials. Nature. PMID 33408408 DOI: 10.1038/s41586-020-03120-8  0.454
2020 Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, et al. Designed proteins assemble antibodies into modular nanocages. Biorxiv : the Preprint Server For Biology. PMID 33299994 DOI: 10.1101/2020.12.01.406611  0.344
2020 Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, et al. Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens. Elife. 9. PMID 32748788 DOI: 10.7554/Elife.57659  0.456
2020 Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park Y, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, et al. Author response: Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens Elife. DOI: 10.7554/Elife.57659.Sa2  0.445
2019 Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, et al. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. Nature Communications. 10: 4272. PMID 31537780 DOI: 10.1038/S41467-019-12080-1  0.384
2019 Foight GW, Wang Z, Wei CT, Jr Greisen P, Warner KM, Cunningham-Bryant D, Park K, Brunette TJ, Sheffler W, Baker D, Maly DJ. Multi-input chemical control of protein dimerization for programming graded cellular responses. Nature Biotechnology. PMID 31501561 DOI: 10.1038/S41587-019-0242-8  0.435
2019 Marcandalli J, Fiala B, Ols S, Perotti M, de van der Schueren W, Snijder J, Hodge E, Benhaim M, Ravichandran R, Carter L, Sheffler W, Brunner L, Lawrenz M, Dubois P, Lanzavecchia A, et al. Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus. Cell. 176: 1420-1431.e17. PMID 30849373 DOI: 10.1016/J.Cell.2019.01.046  0.419
2018 Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, et al. De novo design of self-assembling helical protein filaments. Science (New York, N.Y.). 362: 705-709. PMID 30409885 DOI: 10.2210/Pdb6E9R/Pdb  0.643
2018 Dou J, Vorobieva AA, Sheffler W, Doyle LA, Park H, Bick MJ, Mao B, Foight GW, Lee MY, Gagnon LA, Carter L, Sankaran B, Ovchinnikov S, Marcos E, Huang PS, et al. De novo design of a fluorescence-activating β-barrel. Nature. PMID 30209393 DOI: 10.1038/S41586-018-0509-0  0.736
2018 Marze NA, Roy Burman SS, Sheffler W, Gray JJ. Efficient Flexible Backbone Protein-Protein Docking for Challenging Targets. Bioinformatics (Oxford, England). PMID 29718115 DOI: 10.1093/Bioinformatics/Bty355  0.566
2018 Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. Accurate computational design of multipass transmembrane proteins. Science (New York, N.Y.). 359: 1042-1046. PMID 29496880 DOI: 10.1126/Science.Aaq1739  0.764
2018 Sahasrabuddhe A, Hsia Y, Busch F, Sheffler W, King NP, Baker D, Wysocki VH. Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS. Proceedings of the National Academy of Sciences of the United States of America. PMID 29351988 DOI: 10.1073/Pnas.1713646115  0.541
2018 Roy Burman SS, Marze NA, Sheffler W, Gray JJ. Efficient Flexible-Backbone Docking of Challenging Protein Complexes Biophysical Journal. 114: 344a. DOI: 10.1016/J.Bpj.2017.11.1919  0.567
2017 Strauch EM, Bernard SM, La D, Bohn AJ, Lee PS, Anderson CE, Nieusma T, Holstein CA, Garcia NK, Hooper KA, Ravichandran R, Nelson JW, Sheffler W, Bloom JD, Lee KK, et al. Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site. Nature Biotechnology. PMID 28604661 DOI: 10.1038/Nbt.3907  0.76
2017 Fallas JA, Ueda G, Sheffler W, Nguyen V, McNamara DE, Sankaran B, Pereira JH, Parmeggiani F, Brunette TJ, Cascio D, Yeates TR, Zwart P, Baker D. Computational design of self-assembling cyclic protein homo-oligomers. Nature Chemistry. 9: 353-360. PMID 28338692 DOI: 10.1038/nchem.2673  0.512
2016 Mills JH, Sheffler W, Ener ME, Almhjell PJ, Oberdorfer G, Pereira JH, Parmeggiani F, Sankaran B, Zwart PH, Baker D. Computational design of a homotrimeric metalloprotein with a trisbipyridyl core. Proceedings of the National Academy of Sciences of the United States of America. PMID 27940918 DOI: 10.1073/Pnas.1600188113  0.748
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Corrigendum: Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27760110 DOI: 10.1038/Nature20108  0.721
2016 Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D. Accurate design of megadalton-scale two-component icosahedral protein complexes. Science (New York, N.Y.). 353: 389-394. PMID 27463675 DOI: 10.1126/Science.Aaf8818  0.526
2016 Hsia Y, Bale JB, Gonen S, Shi D, Sheffler W, Fong KK, Nattermann U, Xu C, Huang PS, Ravichandran R, Yi S, Davis TN, Gonen T, King NP, Baker D. Design of a hyperstable 60-subunit protein icosahedron. Nature. PMID 27309817 DOI: 10.1038/Nature18010  0.761
2014 King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D. Accurate design of co-assembling multi-component protein nanomaterials. Nature. 510: 103-8. PMID 24870237 DOI: 10.1038/Nature13404  0.572
2014 Lai Y, King NP, Sheffler W, McNamara DE, Bale JB, Baker D, Yeates TO. Symmetry-Based Design and Structure of Self-Assembling Protein Cages and Nanomaterials Biophysical Journal. 106: 445a. DOI: 10.1016/J.Bpj.2013.11.2516  0.575
2013 Wittenberg G, Sheffler W, Darchi D, Baker D, Noy D. Accelerated electron transport from photosystem I to redox partners by covalently linked ferredoxin. Physical Chemistry Chemical Physics : Pccp. 15: 19608-14. PMID 24129892 DOI: 10.1039/C3Cp53264J  0.424
2012 King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, André I, Gonen T, Yeates TO, Baker D. Computational design of self-assembling protein nanomaterials with atomic level accuracy. Science (New York, N.Y.). 336: 1171-4. PMID 22654060 DOI: 10.1126/Science.1219364  0.563
2011 Read RJ, Adams PD, Arendall WB, Brunger AT, Emsley P, Joosten RP, Kleywegt GJ, Krissinel EB, Lütteke T, Otwinowski Z, Perrakis A, Richardson JS, Sheffler WH, Smith JL, Tickle IJ, et al. A new generation of crystallographic validation tools for the protein data bank. Structure (London, England : 1993). 19: 1395-412. PMID 22000512 DOI: 10.1016/J.Str.2011.08.006  0.368
2011 Wang RYR, Han Y, Krassovsky K, Sheffler W, Tyka M, Baker D. Modeling disordered regions in proteins using Rosetta Plos One. 6. PMID 21829444 DOI: 10.1371/Journal.Pone.0022060  0.457
2011 Leaver-Fay A, Tyka M, Lewis SM, Lange OF, Thompson J, Jacak R, Kaufman K, Renfrew PD, Smith CA, Sheffler W, Davis IW, Cooper S, Treuille A, Mandell DJ, Richter F, et al. ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules. Methods in Enzymology. 487: 545-74. PMID 21187238 DOI: 10.1016/B978-0-12-381270-4.00019-6  0.655
2010 Sheffler W, Baker D. RosettaHoles2: A volumetric packing measure for protein structure refinement and validation Protein Science. 19: 1991-1995. PMID 20665689 DOI: 10.1002/Pro.458  0.507
2009 Raman S, Vernon R, Thompson J, Tyka M, Sadreyev R, Pei J, Kim D, Kellogg E, DiMaio F, Lange O, Kinch L, Sheffler W, Kim BH, Das R, Grishin NV, et al. Structure prediction for CASP8 with all-atom refinement using Rosetta. Proteins. 77: 89-99. PMID 19701941 DOI: 10.1002/Prot.22540  0.768
2009 Sheffler W, Baker D. RosettaHoles: Rapid assessment of protein core packing for structure prediction, refinement, design, and validation Protein Science. 18: 229-239. PMID 19177366 DOI: 10.1002/Pro.8  0.543
2008 Qiu J, Sheffler W, Baker D, Noble WS. Ranking predicted protein structures with support vector regression. Proteins. 71: 1175-82. PMID 18004754 DOI: 10.1002/Prot.21809  0.49
2007 Das R, Qian B, Raman S, Vernon R, Thompson J, Bradley P, Khare S, Tyka MD, Bhat D, Chivian D, Kim DE, Sheffler WH, Malmström L, Wollacott AM, Wang C, et al. Structure prediction for CASP7 targets using extensive all-atom refinement with Rosetta@home. Proteins. 69: 118-28. PMID 17894356 DOI: 10.1002/Prot.21636  0.679
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