Chad J. Creighton, Ph.D. - Publications

Affiliations: 
2006 University of Michigan, Ann Arbor, Ann Arbor, MI 

356 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kundu ST, Rodriguez BL, Gibson LA, Warner AN, Perez MG, Bajaj R, Fradette JJ, Class CA, Solis LM, Rojas Alvarez FR, Wistuba II, Diao L, Chen F, Sachdeva M, Wang J, ... ... Creighton CJ, et al. The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8 cytotoxic T-cell response. Genes & Development. PMID 35654454 DOI: 10.1101/gad.349321.121  0.307
2022 Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJ. Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nature Communications. 13: 2669. PMID 35562349 DOI: 10.1038/s41467-022-30342-3  0.369
2022 Wang W, Han D, Cai Q, Shen T, Dong B, Lewis MT, Wang R, Meng Y, Zhou W, Yi P, Creighton CJ, Moore DD, Yang F. MAPK4 promotes triple negative breast cancer growth and reduces tumor sensitivity to PI3K blockade. Nature Communications. 13: 245. PMID 35017531 DOI: 10.1038/s41467-021-27921-1  0.358
2021 Tan X, Banerjee P, Liu X, Yu J, Lee S, Ahn YH, Creighton CJ, Kurie JM. Transcriptional control of a collagen deposition and adhesion process that promotes lung adenocarcinoma growth and metastasis. Jci Insight. PMID 34874914 DOI: 10.1172/jci.insight.153948  0.316
2021 Zhang Y, Chen F, Pleasance E, Williamson L, Grisdale CJ, Titmuss E, Laskin J, Jones SJM, Cortes-Ciriano I, Marra MA, Creighton CJ. Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy. Cell Reports. 37: 110023. PMID 34788622 DOI: 10.1016/j.celrep.2021.110023  0.309
2021 Wang Z, Hulsurkar M, Zhuo L, Xu J, Yang H, Naderinezhad S, Wang L, Zhang G, Ai N, Li L, Chang JT, Zhang S, Fazli L, Creighton CJ, Bai F, et al. CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. Neoplasia (New York, N.Y.). 23: 1147-1165. PMID 34706306 DOI: 10.1016/j.neo.2021.09.005  0.342
2021 Tan X, Banerjee P, Shi L, Xiao GY, Rodriguez BL, Grzeskowiak CL, Liu X, Yu J, Gibbons DL, Russell WK, Creighton CJ, Kurie JM. p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi. Science Advances. 7. PMID 34144984 DOI: 10.1126/sciadv.abf4885  0.318
2021 Yue F, Jiang W, Ku AT, Young AIJ, Zhang W, Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, Nagi C, Wang T, Hilsenbeck SG, Feng XH, Huang S, et al. A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis. Cancer Research. PMID 34099494 DOI: 10.1158/0008-5472.CAN-21-1112  0.34
2021 Bota-Rabassedas N, Banerjee P, Niu Y, Cao W, Luo J, Xi Y, Tan X, Sheng K, Ahn YH, Lee S, Parra ER, Rodriguez-Canales J, Albritton J, Weiger M, Liu X, ... ... Creighton CJ, et al. Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity. Cell Reports. 35: 109009. PMID 33882319 DOI: 10.1016/j.celrep.2021.109009  0.365
2021 Monsivais D, Vasquez YM, Chen F, Zhang Y, Chandrashekar DS, Faver JC, Masand RP, Scheurer ME, Varambally S, Matzuk MM, Creighton CJ. Mass-spectrometry-based proteomic correlates of grade and stage reveal pathways and kinases associated with aggressive human cancers. Oncogene. PMID 33627787 DOI: 10.1038/s41388-021-01681-0  0.314
2021 Chen F, Zhang Y, Creighton CJ. Systematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers. Nar Cancer. 3: zcab001. PMID 33554123 DOI: 10.1093/narcan/zcab001  0.308
2021 Addison JB, Voronkova MA, Fugett JH, Lin CC, Linville NC, Trinh B, Livengood RH, Smolkin MB, Schaller MD, Ruppert JM, Pugacheva EN, Creighton CJ, Ivanov AV. Functional hierarchy and cooperation of EMT master transcription factors in breast cancer metastasis. Molecular Cancer Research : McR. PMID 33500360 DOI: 10.1158/1541-7786.MCR-20-0532  0.349
2020 Wetendorf M, Li R, Wu SP, Liu J, Creighton CJ, Wang T, Janardhan KS, Willson CJ, Lanz RB, Murphy BD, Lydon JP, DeMayo FJ. Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms. Science Signaling. 13. PMID 33023986 DOI: 10.1126/scisignal.aaz9646  0.328
2020 Tan X, Shi L, Banerjee P, Liu X, Guo HF, Yu J, Bota-Rabassedas N, Rodriguez BL, Gibbons DL, Russell WK, Creighton CJ, Kurie JM. A pro-tumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma. The Journal of Clinical Investigation. PMID 32931483 DOI: 10.1172/Jci137186  0.368
2020 Vykoukal J, Fahrmann JF, Gregg JR, Tang Z, Basourakos S, Irajizad E, Park S, Yang G, Creighton CJ, Fleury A, Mayo J, Paulucci-Holthauzen A, Dennison JB, Murage E, Peterson CB, et al. Caveolin-1-mediated sphingolipid oncometabolism underlies a metabolic vulnerability of prostate cancer. Nature Communications. 11: 4279. PMID 32855410 DOI: 10.1038/S41467-020-17645-Z  0.399
2020 Wang X, Wendel JRH, Emerson RE, Broaddus RR, Creighton CJ, Rusch DB, Buechlein A, DeMayo FJ, Lydon JP, Hawkins SM. Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Oncogene. PMID 32843721 DOI: 10.1038/S41388-020-01434-5  0.478
2020 Bajaj R, Kundu ST, Grzeskowiak CL, Fradette JJ, Scott KL, Creighton CJ, Gibbons DL. IMPAD1 and KDELR2 drive invasion and metastasis by enhancing Golgi-mediated secretion. Oncogene. PMID 32753652 DOI: 10.1038/S41388-020-01410-Z  0.379
2020 Kwon OJ, Choi JM, Zhang L, Jia D, Li Z, Zhang Y, Jung SY, Creighton CJ, Xin L. The Sca-1 and Sca-1 mouse prostatic luminal cell lineages are independently sustained. Stem Cells (Dayton, Ohio). PMID 32627901 DOI: 10.1002/Stem.3253  0.343
2020 Kim O, Park EY, Klinkebiel DL, Pack SD, Shin YH, Abdullaev Z, Emerson RE, Coffey DM, Kwon SY, Creighton CJ, Kwon S, Chang EC, Chiang T, Yatsenko AN, Chien J, et al. In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. Plos Genetics. 16: e1008808. PMID 32497036 DOI: 10.1371/Journal.Pgen.1008808  0.413
2020 Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, et al. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. PMID 32359397 DOI: 10.1016/J.Ccell.2020.04.002  0.331
2020 Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, et al. Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nature Genetics. PMID 32047324 DOI: 10.1038/S41588-020-0587-4  0.31
2020 Calabrese C, Davidson NR, Demircioğlu D, Fonseca NA, He Y, Kahles A, Lehmann KV, Liu F, Shiraishi Y, Soulette CM, Urban L, Greger L, Li S, Liu D, ... ... Creighton CJ, et al. Genomic basis for RNA alterations in cancer. Nature. 578: 129-136. PMID 32025019 DOI: 10.1038/S41586-020-1970-0  0.391
2020 Yuan Y, Ju YS, Kim Y, Li J, Wang Y, Yoon CJ, Yang Y, Martincorena I, Creighton CJ, Weinstein JN, Xu Y, Han L, Kim HL, Nakagawa H, Park K, et al. Comprehensive molecular characterization of mitochondrial genomes in human cancers. Nature Genetics. PMID 32024997 DOI: 10.1038/S41588-019-0557-X  0.388
2020 Zhang Y, Chen F, Fonseca NA, He Y, Fujita M, Nakagawa H, Zhang Z, Brazma A, Creighton CJ. High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. Nature Communications. 11: 736. PMID 32024823 DOI: 10.1038/S41467-019-13885-W  0.415
2020 Tan X, Banerjee P, Pham EA, Rutaganira FUN, Basu K, Bota-Rabassedas N, Guo HF, Grzeskowiak CL, Liu X, Yu J, Shi L, Peng DH, Rodriguez BL, Zhang J, Zheng V, ... ... Creighton CJ, et al. PI4KIIIβ is a therapeutic target in chromosome 1q-amplified lung adenocarcinoma. Science Translational Medicine. 12. PMID 31969487 DOI: 10.1126/Scitranslmed.Aax3772  0.412
2020 Jung K, Park J, Sirupangi T, Jia D, Gandhi N, Pudakalakatti S, Elswood J, Porter W, Putluri N, Zhang XH-, Chen X, Bhattacharya PK, Creighton CJ, Lewis MT, Rosen JM, et al. Abstract P3-06-12: Autophagy-mediated survival mechanism to c-Src inhibitor therapy in triple negative breast cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P3-06-12  0.428
2020 King TA, Liu MC, McClure MB, Hinoue T, Kelly BJ, Creighton CJ, Bowen J, Leraas K, Burns RT, Coppens S, Rezk S, Garrett AL, Balko JM, Parker JS, Park BH, et al. Abstract GS3-08: Multiplatform analysis of matched primary and metastatic breast tumors from the AURORA US Network Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-Gs3-08  0.439
2019 Chen F, Chandrashekar DS, Varambally S, Creighton CJ. Pan-cancer molecular subtypes revealed by mass-spectrometry-based proteomic characterization of more than 500 human cancers. Nature Communications. 10: 5679. PMID 31831737 DOI: 10.1038/S41467-019-13528-0  0.441
2019 Creighton CJ. Proteomic signatures of clear cell renal cell carcinoma. Nature Reviews. Nephrology. PMID 31780818 DOI: 10.1038/S41581-019-0233-5  0.34
2019 Manshouri R, Coyaud E, Kundu ST, Peng DH, Stratton SA, Alton K, Bajaj R, Fradette JJ, Minelli R, Peoples MD, Carugo A, Chen F, Bristow C, Kovacs JJ, Barton MC, ... ... Creighton CJ, et al. ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer. Nature Communications. 10: 5125. PMID 31719531 DOI: 10.1038/S41467-019-12832-Z  0.418
2019 Thangavel H, Angelis C, Vasaikar S, Bhat R, Jolly MK, Nagi C, Creighton CJ, Chen F, Dobrolecki LE, George JT, Kumar T, Abdulkareem NM, Mao S, Nardone A, Rimawi M, et al. A CTC-Cluster-Specific Signature Derived from OMICS Analysis of Patient-Derived Xenograft Tumors Predicts Outcomes in Basal-Like Breast Cancer. Journal of Clinical Medicine. 8. PMID 31652963 DOI: 10.3390/Jcm8111772  0.434
2019 Zhang Y, Yang L, Kucherlapati M, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, Sun H, ... ... Creighton CJ, et al. Global impact of somatic structural variation on the DNA methylome of human cancers. Genome Biology. 20: 209. PMID 31610796 DOI: 10.1186/S13059-019-1818-9  0.376
2019 Fahrmann JF, Vykoukal J, Fleury A, Tripathi S, Dennison JB, Murage E, Wang P, Yu CY, Capello M, Creighton CJ, Do KA, Long JP, Irajizad E, Peterson C, Katayama H, et al. Association between plasma diacetylspermine and tumor spermine synthase with outcome in triple negative breast cancer. Journal of the National Cancer Institute. PMID 31503278 DOI: 10.1093/Jnci/Djz182  0.4
2019 Thakur VS, Aguila B, Brett-Morris A, Creighton CJ, Welford SM. Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness. Oncogene. PMID 31399646 DOI: 10.1038/S41388-019-0917-0  0.407
2019 Kim SJ, Garcia-Recio S, Creighton CJ, Perou CM, Rosen JM. Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression. Oncogene. PMID 31289359 DOI: 10.1038/S41388-019-0852-0  0.419
2019 Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ. JNK represses Lkb-deficiency-induced lung squamous cell carcinoma progression. Nature Communications. 10: 2148. PMID 31089135 DOI: 10.1038/S41467-019-09843-1  0.345
2019 Monsivais D, Kriseman M, Creighton CJ, Matzuk MM. Reply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus. Proceedings of the National Academy of Sciences of the United States of America. 116: 9166-9167. PMID 31068478 DOI: 10.1073/Pnas.1904354116  0.382
2019 Mukhopadhyay UK, Oturkar CC, Adams C, Wickramasekera N, Bansal S, Medisetty R, Miller A, Swetzig WM, Silwal-Pandit L, Borresen-Dale AL, Creighton CJ, Park JH, Konduri SD, Mukhopadhyay A, Caradori A, et al. TP53 Status as a Determinant of Pro- versus Anti-tumorigenic Effects of Estrogen Receptor-beta in Breast Cancer. Journal of the National Cancer Institute. PMID 30990221 DOI: 10.1093/Jnci/Djz051  0.357
2019 Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, et al. Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell. PMID 30982770 DOI: 10.1016/J.Stem.2019.03.010  0.325
2019 Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra JG, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka ZP, Casuscelli J, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 8. PMID 30924768 DOI: 10.7554/Elife.38986  0.387
2019 Kwon OJ, Zhang Y, Li Y, Wei X, Zhang L, Chen R, Creighton CJ, Xin L. Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq. Iscience. 13: 328-338. PMID 30878879 DOI: 10.1016/J.Isci.2019.02.032  0.378
2019 Wang W, Shen T, Dong B, Creighton CJ, Meng Y, Zhou W, Shi Q, Zhou H, Zhang Y, Moore DD, Yang F. MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling. The Journal of Clinical Investigation. PMID 30688659 DOI: 10.1172/Jci97712  0.45
2019 Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MM. Uterine double-conditional inactivation of and in mice causes endometrial dysregulation, infertility, and uterine cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30651315 DOI: 10.1073/Pnas.1806862116  0.397
2019 Bhat R, Qin L, Angelis CD, Sahay D, Bhargava D, Creighton C, Yadav P, Yazdanfard S, Alrawi A, Yadav V, Vasaikar S, Nanda S, Sethunath V, Fu X, Zhang B, et al. Abstract P6-20-10: Role of GPR110 in breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-P6-20-10  0.365
2019 Jung K, Park J, Sirupangi T, Jia D, Gandhi N, Pudakalakatti S, Elswood J, Porter W, Putluri N, Zhang X, Chen X, Bhattacharya P, Creighton C, Lewis M, Rosen J, et al. Abstract P2-02-14: Metabolic regulation and drug resistance in c-Src activated triple negative breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P2-02-14  0.421
2019 Chandrashekar DS, Creighton CJ, Ponce-Rodriguez I, Varambally S. Abstract 2481: Developing analysis platform for pan-cancer study of DNA methylation, mirna and lncrna expression based on tumor subtypes using TCGA data Cancer Research. 79: 2481-2481. DOI: 10.1158/1538-7445.Am2019-2481  0.448
2018 Chen F, Zhang Y, Varambally S, Creighton CJ. Molecular correlates of metastasis by systematic pan-cancer analysis across The Cancer Genome Atlas. Molecular Cancer Research : McR. PMID 30401717 DOI: 10.1158/1541-7786.Mcr-18-0601  0.482
2018 Bu W, Liu Z, Jiang W, Nagi C, Huang S, Edwards DP, Jo E, Mo Q, Creighton CJ, Hilsenbeck SG, Leavitt AD, Lewis MT, Wong STC, Li Y. Mammary precancerous stem and non-stem cells evolve into cancers of distinct subtypes. Cancer Research. PMID 30401712 DOI: 10.1158/0008-5472.Can-18-1087  0.425
2018 Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, ... ... Creighton CJ, et al. Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. Cell Reports. 25: 1304-1317.e5. PMID 30380420 DOI: 10.1016/J.Celrep.2018.10.001  0.481
2018 Suer I, Guzel E, Karatas OF, Creighton CJ, Ittmann M, Ozen M. MicroRNAs as prognostic markers in prostate cancer. The Prostate. PMID 30345533 DOI: 10.1002/Pros.23731  0.358
2018 Classe M, Yao H, Mouawad R, Creighton CJ, Burgess A, Allanic F, Wassef M, Leroy X, Verillaud B, Mortuaire G, Bielle F, Le Tourneau C, Kurtz JE, Khayat D, Su X, et al. Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. Cell Reports. 25: 811-821.e5. PMID 30332658 DOI: 10.1016/J.Celrep.2018.09.047  0.366
2018 Lu Y, Cao J, Napoli M, Xia Z, Zhao N, Creighton CJ, Li W, Chen X, Flores ER, McManus MT, Rosen JM. MiR-205 Regulates Basal Cell Identity and Stem Cell Regenerative Potential during Mammary Reconstitution. Stem Cells (Dayton, Ohio). PMID 30267595 DOI: 10.1002/Stem.2914  0.33
2018 Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Cao J, Anurag M, Singh P, He X, Kosaka Y, Matsunuma R, Crowder R, Hoog J, Phommaly C, Goncalves R, ... ... Creighton CJ, et al. Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Reports. 24: 1434-1444.e7. PMID 30089255 DOI: 10.1016/J.Celrep.2018.07.009  0.402
2018 Kundu ST, Grzeskowiak CL, Fradette JJ, Gibson LA, Rodriguez LB, Creighton CJ, Scott KL, Gibbons DL. TMEM106B drives lung cancer metastasis by inducing TFEB-dependent lysosome synthesis and secretion of cathepsins. Nature Communications. 9: 2731. PMID 30013069 DOI: 10.1038/S41467-018-05013-X  0.438
2018 Grzeskowiak CL, Kundu ST, Mo X, Ivanov AA, Zagorodna O, Lu H, Chapple RH, Tsang YH, Moreno D, Mosqueda M, Eterovic K, Fradette JJ, Ahmad S, Chen F, Chong Z, ... ... Creighton CJ, et al. In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nature Communications. 9: 2732. PMID 30013058 DOI: 10.1038/S41467-018-04572-3  0.389
2018 Zhang Y, Yang L, Kucherlapati M, Chen F, Hadjipanayis A, Pantazi A, Bristow CA, Lee EA, Mahadeshwar HS, Tang J, Zhang J, Seth S, Lee S, Ren X, Song X, ... ... Creighton CJ, et al. A Pan-Cancer Compendium of Genes Deregulated by Somatic Genomic Rearrangement across More Than 1,400 Cases. Cell Reports. 24: 515-527. PMID 29996110 DOI: 10.1016/J.Celrep.2018.06.025  0.429
2018 Reddy JP, Atkinson RL, Larson R, Burks JK, Smith D, Debeb BG, Ruffell B, Creighton CJ, Bambhroliya A, Reuben JM, Van Laere SJ, Krishnamurthy S, Symmans WF, Brewster AM, Woodward WA. Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer. Breast Cancer Research and Treatment. PMID 29858753 DOI: 10.1007/S10549-018-4835-6  0.389
2018 You R, DeMayo FJ, Liu J, Cho SN, Burt BM, Creighton CJ, Casal RF, Lazarus DR, Lu W, Tung HY, Yuan X, Hill AA, Kim M, Perusich S, Cornwell LD, et al. IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer. Cancer Immunology Research. PMID 29653981 DOI: 10.1158/2326-6066.Cir-17-0554  0.408
2018 Campbell JD, Yau C, Bowlby R, Liu Y, Brennan K, Fan H, Taylor AM, Wang C, Walter V, Akbani R, Byers LA, Creighton CJ, Coarfa C, Shih J, Cherniack AD, et al. Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas. Cell Reports. 23: 194-212.e6. PMID 29617660 DOI: 10.1016/J.Celrep.2018.03.063  0.367
2018 Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. Plos One. 13: e0194913. PMID 29590203 DOI: 10.1371/Journal.Pone.0194913  0.49
2018 Shao L, Wang J, Karatas OF, Feng S, Zhang Y, Creighton CJ, Ittmann M. Fibroblast growth factor receptor signaling plays a key role in transformation induced by the TMPRSS2/ERG fusion gene and decreased PTEN. Oncotarget. 9: 14456-14471. PMID 29581856 DOI: 10.18632/Oncotarget.24470  0.425
2018 Nair A, Chung HC, Sun T, Tyagi S, Dobrolecki LE, Dominguez-Vidana R, Kurley SJ, Orellana M, Renwick A, Henke DM, Katsonis P, Schmitt E, Chan DW, Li H, Mao S, ... ... Creighton CJ, et al. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer. Nature Medicine. PMID 29578538 DOI: 10.1038/Nm.4507  0.413
2018 Bhat RR, Yadav P, Sahay D, Bhargava DK, Creighton CJ, Yazdanfard S, Al-Rawi A, Yadav V, Qin L, Nanda S, Sethunath V, Fu X, De Angelis C, Narkar VA, Osborne CK, et al. GPCRs profiling and identification of GPR110 as a potential new target in HER2+ breast cancer. Breast Cancer Research and Treatment. PMID 29574636 DOI: 10.1007/S10549-018-4751-9  0.403
2018 Danussi C, Bose P, Parthasarathy PT, Silberman PC, Van Arnam JS, Vitucci M, Tang OY, Heguy A, Wang Y, Chan TA, Riggins GJ, Sulman EP, Lang F, Creighton CJ, Deneen B, et al. Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nature Communications. 9: 1057. PMID 29535300 DOI: 10.1038/S41467-018-03476-6  0.369
2018 Yu-Lee LY, Yu G, Lee YC, Lin SC, Pan J, Pan T, Yu KJ, Liu B, Creighton CJ, Rodriguez-Canales J, Villalobos PA, Wistuba II, de Nadal E, Posas F, Gallick GE, et al. Osteoblast-secreted factors mediate dormancy of metastatic prostate cancer in the bone via activation of the TGFβRIII-p38MAPK-pS249/T252RB pathway. Cancer Research. PMID 29514796 DOI: 10.1158/0008-5472.Can-17-1051  0.378
2018 Creighton CJ, Chen F, Zhang Y, Gibbons DL, Deneen B, Kwiatkowski D, Ittmann M. Pan-cancer molecular classes transcending tumor lineage across 32 cancer types, multiple data platforms, and over 10,000 cases. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29440175 DOI: 10.1158/1078-0432.Ccr-17-3378  0.424
2018 Reznik E, Luna A, Aksoy BA, Liu EM, La K, Ostrovnaya I, Creighton CJ, Hakimi AA, Sander C. A Landscape of Metabolic Variation across Tumor Types. Cell Systems. PMID 29396322 DOI: 10.1016/J.Cels.2017.12.014  0.383
2018 Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu X, ... ... Creighton CJ, et al. The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. The Journal of Clinical Investigation. PMID 29324442 DOI: 10.1172/Jci97225  0.361
2018 Lei J, Shao J, Zhang J, Iglesia M, Chan D, Cao J, Anurag M, Singh P, Haricharan S, Kavuri S, Matsunuma R, Schmidt C, Kosaka Y, Crowder R, Hoog J, ... ... Creighton C, et al. Abstract PD8-03: ESR1 gene fusions drive endocrine therapy resistance and metastasis in breast cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-Pd8-03  0.462
2018 Jung KH, Park JH, Sirupangi T, Jia D, Pudakalakatti S, Gandhi N, Elswood J, Putluri V, Creighton CJ, Porter W, Lewis MT, Chen X, Putluri N, Bhattacharya PK, Wong LC, et al. Abstract 1331: Inhibition of mitochondrial reprogramming regulated c-Src in triple-negative breast cancer activates autophagy-mediated survival mechanism Cancer Research. 78: 1331-1331. DOI: 10.1158/1538-7445.Am2018-1331  0.41
2017 Hsieh JJ, Le V, Cao D, Cheng EH, Creighton CJ. Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan-omics precision. The Journal of Pathology. PMID 29266437 DOI: 10.1002/Path.5022  0.362
2017 El-Shennawy L, Dubrovskyi O, Kastrati I, Danes JM, Zhang Y, Whiteley HE, Creighton CJ, Frasor J. Coactivation of estrogen receptor and IKK-β induces a dormant metastatic phenotype in ER-positive breast cancer. Cancer Research. PMID 29229606 DOI: 10.1158/0008-5472.Can-17-1686  0.463
2017 Coarfa C, Florentin D, Putluri N, Ding Y, Au J, He D, Ragheb A, Frolov A, Michailidis G, Lee M, Kadmon D, Miles B, Smith C, Ittmann M, Rowley D, ... ... Creighton CJ, et al. Influence of the neural microenvironment on prostate cancer. The Prostate. PMID 29131367 DOI: 10.1002/Pros.23454  0.341
2017 Sreekumar A, Toneff MJ, Toh E, Roarty K, Creighton CJ, Belka GK, Lee DK, Xu J, Chodosh LA, Richards JS, Rosen JM. WNT-Mediated Regulation of FOXO1 Constitutes a Critical Axis Maintaining Pubertal Mammary Stem Cell Homeostasis. Developmental Cell. PMID 29103953 DOI: 10.1016/J.Devcel.2017.10.007  0.378
2017 Zhu W, Krishna S, Garcia C, Lin CJ, Mitchell BD, Scott KL, Mohila CA, Creighton CJ, Yoo SH, Lee HK, Deneen B. Daam2 driven degradation of VHL promotes gliomagenesis. Elife. 6. PMID 29053101 DOI: 10.7554/Elife.31926  0.464
2017 Karatas OF, Wang J, Shao L, Ozen M, Zhang Y, Creighton CJ, Ittmann M. miR-33a is a tumor suppressor microRNA that is decreased in prostate cancer. Oncotarget. 8: 60243-60256. PMID 28947967 DOI: 10.18632/Oncotarget.19521  0.384
2017 Glasgow SM, Carlson JC, Zhu W, Chaboub LS, Kang P, Lee HK, Clovis YM, Lozzi BE, McEvilly RJ, Rosenfeld MG, Creighton CJ, Lee SK, Mohila CA, Deneen B. Glia-specific enhancers and chromatin structure regulate NFIA expression and glioma tumorigenesis. Nature Neuroscience. PMID 28892058 DOI: 10.1038/Nn.4638  0.344
2017 Carron EC, Homra S, Rosenberg J, Coffelt SB, Kittrell F, Zhang Y, Creighton CJ, Fuqua SA, Medina D, Machado HL. Macrophages promote the progression of premalignant mammary lesions to invasive cancer. Oncotarget. 8: 50731-50746. PMID 28881599 DOI: 10.18632/Oncotarget.14913  0.391
2017 Chen F, Zhang Y, Bossé D, Lalani AA, Hakimi AA, Hsieh JJ, Choueiri TK, Gibbons DL, Ittmann M, Creighton CJ. Pan-urologic cancer genomic subtypes that transcend tissue of origin. Nature Communications. 8: 199. PMID 28775315 DOI: 10.1038/S41467-017-00289-X  0.446
2017 Schliekelman MJ, Creighton CJ, Baird BN, Chen Y, Banerjee P, Bota-Rabassedas N, Ahn YH, Roybal JD, Chen F, Zhang Y, Mishra DK, Kim MP, Liu X, Mino B, Villalobos P, et al. Thy-1(+) Cancer-associated Fibroblasts Adversely Impact Lung Cancer Prognosis. Scientific Reports. 7: 6478. PMID 28744021 DOI: 10.1038/S41598-017-06922-5  0.399
2017 Chandrashekar DS, Bashel B, Balasubramanya SAH, Creighton CJ, Ponce-Rodriguez I, Chakravarthi BVSK, Varambally S. UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses. Neoplasia (New York, N.Y.). 19: 649-658. PMID 28732212 DOI: 10.1016/J.Neo.2017.05.002  0.455
2017 Wang Z, Kim TB, Peng B, Karam JA, Creighton CJ, Joon AY, Kawakami F, Trevisan P, Jonasch E, Chow CW, Rodriguez-Canales J, Tamboli P, Tannir NM, Wood CG, Monzon FA, et al. Sarcomatoid renal cell carcinoma has a distinct molecular pathogenesis, driver mutation profile and transcriptional landscape. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28710314 DOI: 10.1158/1078-0432.Ccr-17-1057  0.342
2017 Roarty K, Pfefferle AD, Creighton CJ, Perou CM, Rosen JM. Ror2-mediated alternative Wnt signaling regulates cell fate and adhesion during mammary tumor progression. Oncogene. 36: 5958-5968. PMID 28650466 DOI: 10.1038/Onc.2017.206  0.462
2017 Casuscelli J, Weinhold N, Gundem G, Wang L, Zabor EC, Drill E, Wang PI, Nanjangud GJ, Redzematovic A, Nargund AM, Manley BJ, Arcila ME, Donin NM, Cheville JC, Thompson RH, ... ... Creighton CJ, et al. Genomic landscape and evolution of metastatic chromophobe renal cell carcinoma. Jci Insight. 2. PMID 28614790 DOI: 10.1172/Jci.Insight.92688  0.353
2017 Wang Y, Wang J, Zhang L, Karatas OF, Shao LJ, Zhang Y, Castro P, Creighton CJ, Ittmann M. RGS12 is a novel tumor suppressor gene in African American prostate cancer that represses AKT and MNX1 expression. Cancer Research. PMID 28611045 DOI: 10.1158/0008-5472.Can-17-0669  0.446
2017 Croce CM, Casadei L, Calore F, Creighton CJ, Guescini M, Batte K, Iwenofu OH, Zewdu A, Braggio D, Bill KL, Fadda P, Lovat F, Lopez G, Gasparini P, Chen JL, et al. Exosome-derived miR-25-3p and miR-92a-3p stimulate liposarcoma progression. Cancer Research. PMID 28588009 DOI: 10.1158/0008-5472.Can-16-2984  0.303
2017 Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, ... ... Creighton CJ, et al. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. PMID 28528867 DOI: 10.1016/J.Ccell.2017.04.013  0.402
2017 Lu H, Villafane N, Dogruluk T, Grzeskowiak CL, Kong K, Tsang YH, Zagorodna O, Pantazi A, Yang L, Neill NJ, Kim YW, Creighton CJ, Verhaak RG, Mills GB, Park P, et al. Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. Cancer Research. PMID 28512244 DOI: 10.1158/0008-5472.Can-16-2745  0.367
2017 Wang W, Meng Y, Dong B, Dong J, Ittmann MM, Creighton CJ, Yang L, Zhang H, Shen T, Wang J, Rowley DR, Li Y, Chen F, Moore DD, Yang F. A Versatile Tumor Gene Deletion System Reveals a Crucial Role for FGFR1 in Breast Cancer Metastasis. Neoplasia (New York, N.Y.). 19: 421-428. PMID 28433771 DOI: 10.1016/J.Neo.2017.03.003  0.47
2017 Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, Aras O, Han S, Oyama T, Takeda S, Ray CE, Dong Z, Berge M, Hakimi AA, Monette S, ... ... Creighton CJ, et al. The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Cell Reports. 18: 2893-2906. PMID 28329682 DOI: 10.1016/J.Celrep.2017.02.074  0.352
2017 Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment†. Biology of Reproduction. 96: 313-326. PMID 28203817 DOI: 10.1095/Biolreprod.116.144410  0.322
2017 John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, ... Creighton CJ, et al. Identification of diverse astrocyte populations and their malignant analogs. Nature Neuroscience. PMID 28166219 DOI: 10.1038/Nn.4493  0.313
2017 Gibbons DL, Creighton CJ. Pan-cancer survey of epithelial-mesenchymal transition markers across The Cancer Genome Atlas. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 28073171 DOI: 10.1002/dvdy.24485  0.324
2017 Ellis MJ, Suman VJ, Hoog J, Goncalves R, Sanati S, Creighton CJ, DeSchryver K, Crouch E, Brink A, Watson M, Luo J, Tao Y, Barnes M, Dowsett M, Budd GT, et al. Ki67 Proliferation Index as a Tool for Chemotherapy Decisions During and After Neoadjuvant Aromatase Inhibitor Treatment of Breast Cancer: Results From the American College of Surgeons Oncology Group Z1031 Trial (Alliance). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016694406. PMID 28045625 DOI: 10.1200/Jco.2016.69.4406  0.351
2017 Fu X, Pereira R, Zhao D, Jung S, Jeselsohn R, Creighton C, Shea M, Nardone A, Angelis C, Tsimelzon A, Wang T, Gutierrez C, Huang S, Edwards D, Rimawi M, et al. Abstract PD2-04: FOXA1 induces a pro-metastatic secretome through ER-dependent and independent transcriptional reprogramming in endocrine-resistant breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-Pd2-04  0.352
2017 Lei J, Shao J, Zhang J, Iglesia M, Cao J, Chan D, He X, Kosaka Y, Schmidt C, Matsunuma R, Haricharan S, Crowder R, Hoog J, Phommaly C, Goncalves R, ... ... Creighton C, et al. Abstract PD2-03: Recurrent functionally diverse in-frameESR1gene fusions drive endocrine resistance in breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-Pd2-03  0.461
2017 Park J, Jung K, Sirupangi T, Vithayathil S, Jin F, Putluri V, Piyarathna D, Yotnda P, Bhat V, Sreekumar A, Lewis M, Coarfa C, Putluri N, Creighton C, Wong L, et al. Abstract P6-01-07: Mitochondria-nuclear communication regulates epithelial-mesenchymal transition and metastasis in triple negative breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P6-01-07  0.371
2017 Reddy J, Atkinson R, Larson R, Burks J, Smith D, Debeb B, Ruffell B, Creighton C, Reuben J, Krishnamurthy S, Symmans W, Brewster A, Laere SV. Abstract P4-03-14: Stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P4-03-14  0.359
2017 Amin S, Awadalla P, Biankin A, Boutros P, Brazma A, Brooks AN, Calabrese C, Chang D, Chateigner A, Chen K, Chong Z, Craft B, Creighton C, Demircioğlu D, Fonseca N, et al. Abstract SY10-02: Pan-cancer study of recurrent and heterogeneous RNA aberrations and association with whole-genome variants Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Sy10-02  0.329
2017 Lei JT, Shao J, Zhang J, Iglesia M, Chan DW, Matsunuma R, He X, Singh P, Kosaka Y, Crowder R, Haricharan S, Kavuri S, Hoog J, Phommaly C, Goncalves R, ... ... Creighton CJ, et al. Abstract 1033: Estrogen receptor gene fusions drive endocrine therapy resistance in estrogen receptor positive breast cancer Cancer Research. 77: 1033-1033. DOI: 10.1158/1538-7445.Am2017-1033  0.434
2017 Danussi C, Bose P, Parthasarathy P, Silberman P, Arnam JSV, Vitucci M, Tang O, Heguy A, Chan T, Sulman E, Lang F, Creighton CJ, Deneen B, Miller CR, Picketts D, et al. Gene-24. Atrx Deficiency In Glioma Cells Of Origin Promotes Disease-Defining Phenotypes By Way Of Global Epigenomic Remodeling Neuro-Oncology. 19. DOI: 10.1093/Neuonc/Nox168.398  0.334
2016 Zeng H, Ortiz A, Shen PF, Cheng CJ, Lee YC, Yu G, Lin SC, Creighton CJ, Yu-Lee LY, Lin SH. Angiomotin regulates prostate cancer cell proliferation by signaling through the Hippo-YAP pathway. Oncotarget. PMID 28052036 DOI: 10.18632/Oncotarget.14358  0.458
2016 Tan X, Banerjee P, Guo HF, Ireland S, Pankova D, Ahn YH, Nikolaidis IM, Liu X, Zhao Y, Xue Y, Burns AR, Roybal J, Gibbons DL, Zal T, Creighton CJ, et al. Epithelial-to-mesenchymal transition drives a pro-metastatic Golgi compaction process through scaffolding protein PAQR11. The Journal of Clinical Investigation. PMID 27869652 DOI: 10.1172/Jci88736  0.377
2016 Karatas OF, Suer I, Yuceturk B, Yilmaz M, Oz B, Guven G, Cansiz H, Creighton CJ, Ittmann M, Ozen M. Identification of microRNA profile specific to cancer stem-like cells directly isolated from human larynx cancer specimens. Bmc Cancer. 16: 853. PMID 27816053 DOI: 10.1186/S12885-016-2863-3  0.414
2016 Fu X, Jeselsohn R, Pereira R, Hollingsworth EF, Creighton CJ, Li F, Shea M, Nardone A, De Angelis C, Heiser LM, Anur P, Wang N, Grasso CS, Spellman PT, Griffith OL, et al. FOXA1 overexpression mediates endocrine resistance by altering the ER transcriptome and IL-8 expression in ER-positive breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 113: E6600-E6609. PMID 27791031 DOI: 10.1073/Pnas.1612835113  0.419
2016 Chen F, Zhang Y, Parra E, Rodriguez J, Behrens C, Akbani R, Lu Y, Kurie JM, Gibbons DL, Mills GB, Wistuba II, Creighton CJ. Multiplatform-based molecular subtypes of non-small-cell lung cancer. Oncogene. PMID 27775076 DOI: 10.1038/Onc.2016.303  0.4
2016 Peng DH, Ungewiss C, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Uraoka N, Mino B, Behrens C, Wistuba II, Han RI, Wanna CA, Fahrenholtz M, Grande-Allen KJ, ... Creighton CJ, et al. ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. Oncogene. PMID 27694892 DOI: 10.1038/Onc.2016.358  0.462
2016 Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea Iurascu M, Ueno NT, Creighton CJ, Sen S. Aurora Kinase-A Overexpression in Mouse Mammary Epithelium Induces Mammary Adenocarcinomas Harboring Genetic Alterations Shared with Human Breast Cancer. Carcinogenesis. PMID 27624071 DOI: 10.1093/Carcin/Bgw097  0.493
2016 Zhang B, Kwon OJ, Henry G, Malewska A, Wei X, Zhang L, Brinkley W, Zhang Y, Castro PD, Titus M, Chen R, Sayeeduddin M, Raj GV, Mauck R, Roehrborn C, ... Creighton CJ, et al. Non-Cell-Autonomous Regulation of Prostate Epithelial Homeostasis by Androgen Receptor. Molecular Cell. PMID 27594448 DOI: 10.1016/J.Molcel.2016.07.025  0.314
2016 Zhang L, Wang J, Wang Y, Zhang Y, Castro P, Shao L, Sreekumar A, Putluri N, Guha N, Deepak S, Padmanaban A, Creighton CJ, Ittmann M. MNX1 is oncogenically upregulated in African-American prostate cancer. Cancer Research. PMID 27578002 DOI: 10.1158/0008-5472.Can-16-0087  0.347
2016 Malouf GG, Compérat E, Yao H, Mouawad R, Lindner V, Rioux-Leclercq N, Verkarre V, Leroy X, Dainese L, Classe M, Descotes JL, Barthelemy P, Yacoub M, Rouprêt M, Bernhard JC, ... Creighton CJ, et al. Unique Transcriptomic Profile of Collecting Duct Carcinomas Relative to Upper Tract Urothelial Carcinomas and other Kidney Carcinomas. Scientific Reports. 6: 30988. PMID 27484008 DOI: 10.1038/Srep30988  0.356
2016 Verstovsek S, Manshouri T, Pilling D, Bueso-Ramos CE, Newberry KJ, Prijic S, Knez L, Bozinovic K, Harris DM, Spaeth EL, Post SM, Multani AS, Rampal RK, Ahn J, Levine RL, ... Creighton CJ, et al. Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis. The Journal of Experimental Medicine. PMID 27481130 DOI: 10.1084/Jem.20160283  0.308
2016 Zhang T, Guo L, Creighton CJ, Lu Q, Gibbons DL, Yi ES, Deng B, Molina JR, Sun Z, Yang P, Yang Y. A genetic cell context-dependent role for ZEB1 in lung cancer. Nature Communications. 7: 12231. PMID 27456471 DOI: 10.1038/Ncomms12231  0.377
2016 Farach A, Ding Y, Lee M, Creighton C, Delk NA, Ittmann M, Miles B, Rowley D, Farach-Carson MC, Ayala GE. Neuronal trans-differentiation in prostate cancer cells. The Prostate. PMID 27403603 DOI: 10.1002/Pros.23221  0.385
2016 Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. The Journal of Clinical Investigation. PMID 27294523 DOI: 10.1172/Jci84637  0.417
2016 Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY, Tsai MJ. Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nature Communications. 7: 11418. PMID 27108958 DOI: 10.1038/Ncomms11418  0.371
2016 Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Molecular Endocrinology (Baltimore, Md.). me20151215. PMID 27018534 DOI: 10.1210/Me.2015-1215  0.356
2016 Malorni L, Giuliano M, Migliaccio I, Wang T, Creighton CJ, Lupien M, Fu X, Hilsenbeck SG, Healy N, De Angelis C, Mazumdar A, Trivedi MV, Massarweh S, Gutierrez C, De Placido S, et al. Blockade of AP-1 Potentiates Endocrine Therapy and Overcomes Resistance. Molecular Cancer Research : McR. PMID 26965145 DOI: 10.1158/1541-7786.Mcr-15-0423  0.384
2016 Chen F, Zhang Y, Şenbabaoğlu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, ... ... Creighton CJ, et al. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Reports. PMID 26947078 DOI: 10.1016/J.Celrep.2016.02.024  0.366
2016 Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat VB, Bhowmik SK, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, ... ... Creighton CJ, et al. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Reports. PMID 26923594 DOI: 10.1016/J.Celrep.2016.02.004  0.397
2016 Roca FJ, Loomans HA, Wittman AT, Creighton CJ, Hawkins SM. Ten-Eleven Translocation Genes are Downregulated in Endometriosis. Current Molecular Medicine. 16: 288-98. PMID 26917261 DOI: 10.2174/1566524016666160225153844  0.322
2016 Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Research. 76: 1463-75. PMID 26833126 DOI: 10.1158/0008-5472.Can-15-2383  0.448
2016 Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, ... ... Creighton CJ, et al. Functional annotation of rare gene aberration drivers of pancreatic cancer. Nature Communications. 7: 10500. PMID 26806015 DOI: 10.1038/Ncomms10500  0.463
2016 Gingras MC, Covington KR, Chang DK, Donehower LA, Gill AJ, Ittmann MM, Creighton CJ, Johns AL, Shinbrot E, Dewal N, Fisher WE, Pilarsky C, Grützmann R, Overman MJ, et al. Ampullary Cancers Harbor the Tumor Suppressor Gene ELF3 and Exhibit Frequent WNT Dysregulation. Cell Reports. PMID 26804919 DOI: 10.1016/J.Celrep.2015.12.005  0.39
2016 Hakimi AA, Reznik E, Lee CH, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P, Chen YB, Tickoo SK, et al. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. 29: 104-116. PMID 26766592 DOI: 10.1016/J.Ccell.2015.12.004  0.323
2016 Ungewiss C, Rizvi ZH, Roybal JD, Peng DH, Gold KA, Shin DH, Creighton CJ, Gibbons DL. The microRNA-200/Zeb1 axis regulates ECM-dependent β1-integrin/FAK signaling, cancer cell invasion and metastasis through CRKL. Scientific Reports. 6: 18652. PMID 26728244 DOI: 10.1038/Srep18652  0.444
2016 Lerner SP, Kim J, Kwiatkowski DJ, Getz G, Weinstein JN, Cherniack A, Guo G, Akbani R, Hoadley KA, Kim WY, Robertson G, Mungall AJ, Hinoue T, Laird PW, Al-Ahmadie H, ... ... Creighton CJ, et al. Comprehensive characterization of 412 muscle invasive urothelial carcinomas: Final analysis of The Cancer Genome Atlas (TCGA) project. Journal of Clinical Oncology. 34: 405-405. DOI: 10.1200/Jco.2016.34.2_Suppl.405  0.385
2016 Malouf GG, Comperat E, Yao H, Mouawad R, Lindner V, Rioux-Leclercq N, Verkarre V, Leroy X, Dainese L, Classe M, Descotes J, Barthelemy P, Yacoub M, Roupret M, Bernhard J, ... Creighton CJ, et al. Transcriptomic profiling of collecting duct carcinoma to reveal metabolic and immune aberrations. Journal of Clinical Oncology. 34: 4572-4572. DOI: 10.1200/Jco.2016.34.15_Suppl.4572  0.344
2016 Kwon O, Zhang L, Jianghua W, Creighton C, Ittmann M, Xin L. Abstract A36: Notch signaling promotes tumor metastasis in the Pten null mouse model for prostate cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-A36  0.444
2016 Kundu ST, Grzeskowiak C, Creighton CJ, Scott KL, Gibbons DL. Abstract B25: A novel in vivo gain-of-function screen for metastasis drivers in non-small cell lung cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-B25  0.464
2016 Peng DH, Tong P, Byers LA, Wang J, Creighton CJ, Gibbons DL. Abstract A27: Zeb1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-A27  0.461
2016 Zheng Z, Bu W, Tian L, Fan C, Gao X, Zhang X, Yu C, Wang H, Liao Y, Li Y, Lewis M, Edwards D, Zwaka T, Hilsenbeck S, Medina D, ... ... Creighton C, et al. Abstract P2-06-11: Wild type N-Ras, overexpressed in basal-like breast cancer, promotes tumor formation by inducing IL8 secretion via JAK2 activation Cancer Research. 75: 2139-2139. DOI: 10.1158/1538-7445.Sabcs15-P2-06-11  0.393
2016 Casadei L, Creighton C, Batte K, Chelouche-Lev D, Croce CM, Pollock RE. Abstract 966: Circulating exosomal miRNAs as potential biomarker in liposarcoma Cancer Research. 76: 966-966. DOI: 10.1158/1538-7445.Am2016-966  0.319
2016 Kundu S, Grzeskowiak C, Creighton CJ, Scott KL, Gibbons DL. Abstract 688: Identifying TMEM106B as a novel metastasis driver in non-small cell lung cancers through anin vivogain-of-function screen Cancer Research. 76: 688-688. DOI: 10.1158/1538-7445.Am2016-688  0.46
2016 Roarty K, Pfefferle AD, Creighton CJ, Perou CM, Rosen JM. Abstract 3306: Wnt pathway dynamics in breast cancer progression Cancer Research. 76: 3306-3306. DOI: 10.1158/1538-7445.Am2016-3306  0.469
2016 Braggio D, Shang H, Lee Y, Al-Sannaa GA, Creighton CJ, Bolshakov S, Lazar AJ, Lev D, Pollock RE. Abstract 2286: Targeting the notch pathway: A potential therapeutic approach for desmoid tumors Cancer Research. 76: 2286-2286. DOI: 10.1158/1538-7445.Am2016-2286  0.442
2016 Park JH, Vithayathil S, Wu D, Putluri V, Sung P, Tsouko E, Bhat VB, Coarfa C, Frigo DE, Lewis MT, Sreekumar A, Yotnda P, Creighton CJ, Putluri N, Wong LC, et al. Abstract 217: Mitochondrial reprogramming regulated cancer pathway in triple negative breast cancer Cancer Research. 76: 217-217. DOI: 10.1158/1538-7445.Am2016-217  0.42
2016 Weinstein JN, Lerner SP, Kwiatkowski DJ, Getz G, Kim J, Al-ahmadie HA, Cherniack AD, Guo G, Akbani R, Hoadley KA, Kim WY, Robertson G, Mungall AJ, Hinoue T, Laird PW, ... ... Creighton CJ, et al. Abstract 128: Comprehensive molecular characterization of 412 muscle-invasive urothelial bladder carcinomas: final analysis of The Cancer Genome Atlas (TCGA) project Cancer Research. 76: 128-128. DOI: 10.1158/1538-7445.Am2016-128  0.447
2015 Lerner SP, Weinstein J, Kwiatkowski D, Kim J, Robertson G, Hoadley KA, Akbani R, Creighton C. The Cancer Genome Atlas Project on Muscle-invasive Bladder Cancer. European Urology Focus. 1: 94-95. PMID 28723366 DOI: 10.1016/J.Euf.2014.11.002  0.356
2015 Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. Uterine ALK3 is essential during the window of implantation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26721398 DOI: 10.1073/Pnas.1523758113  0.316
2015 Duz MB, Karatas OF, Guzel E, Turgut NF, Yilmaz M, Creighton CJ, Ozen M. Identification of miR-139-5p as a saliva biomarker for tongue squamous cell carcinoma: a pilot study. Cellular Oncology (Dordrecht). PMID 26650483 DOI: 10.1007/S13402-015-0259-Z  0.351
2015 Pankoval D, Chen Y, Terajima M, Schliekelman MJ, Baird BN, Fahrenholtz M, Sun L, Gill BJ, Vadakkan TJ, Kim MP, Ahn YH, Roybal JD, Liu X, Parra Cuentas ER, Rodriguez J, ... ... Creighton CJ, et al. Cancer-associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. Molecular Cancer Research : McR. PMID 26631572 DOI: 10.1158/1541-7786.Mcr-15-0307  0.397
2015 Dogruluk T, Tsang YH, Espitia M, Chen F, Chen T, Chong Z, Appadurai V, Dogruluk A, Eterovic AK, Bonnen PE, Creighton CJ, Chen K, Mills GB, Scott KL. Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. Cancer Research. PMID 26627007 DOI: 10.1158/0008-5472.Can-15-1654  0.386
2015 Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, et al. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. The New England Journal of Medicine. PMID 26536169 DOI: 10.1056/Nejmoa1505917  0.314
2015 Karatas OF, Suer I, Yuceturk B, Yilmaz M, Hajiyev Y, Creighton CJ, Ittmann M, Ozen M. The role of miR-145 in stem cell characteristics of human laryngeal squamous cell carcinoma Hep-2 cells. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 26490990 DOI: 10.1007/S13277-015-4219-Z  0.37
2015 Bill KL, Garnett J, Meaux I, Ma XY, Bolshakov S, Creighton CJ, Barriere C, Dubusche L, Lazar A, Prudner BC, Casadei L, Braggio DA, Lopez G, Zewdu A, Bid HK, et al. SAR405838: A novel and potent inhibitor of the MDM2:p53 axis for the treatment of dedifferentiated liposarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26475335 DOI: 10.1158/1078-0432.Ccr-15-1522  0.351
2015 Kim J, Akbani R, Creighton CJ, Lerner SP, Weinstein JN, Getz G, Kwiatkowski DJ. Invasive Bladder Cancer: Genomic Insights and Therapeutic Promise. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 4514-24. PMID 26473186 DOI: 10.1158/1078-0432.Ccr-14-1215  0.444
2015 Lopez G, Song Y, Lam R, Ruder D, Creighton CJ, Bid HK, Bill KL, Bolshakov S, Zhang X, Lev D, Pollock RE. HDAC Inhibition for the Treatment of Epithelioid Sarcoma: Novel Cross Talk Between Epigenetic Components. Molecular Cancer Research : McR. PMID 26396249 DOI: 10.1158/1541-7786.Mcr-15-0295  0.398
2015 Shang H, Braggio D, Lee YJ, Al Sannaa GA, Creighton CJ, Bolshakov S, Lazar AJ, Lev D, Pollock RE. Targeting the Notch pathway: A potential therapeutic approach for desmoid tumors. Cancer. PMID 26349011 DOI: 10.1002/Cncr.29564  0.342
2015 Fullerton PT, Creighton CJ, Matzuk MM. Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-β Signaling. Molecular Endocrinology (Baltimore, Md.). 29: 1440-53. PMID 26284758 DOI: 10.1210/Me.2015-1102  0.364
2015 Creighton CJ, Huang S. Reverse phase protein arrays in signaling pathways: a data integration perspective. Drug Design, Development and Therapy. 9: 3519-27. PMID 26185419 DOI: 10.2147/Dddt.S38375  0.375
2015 Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, et al. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Reports. PMID 26166574 DOI: 10.1016/J.Celrep.2015.06.044  0.368
2015 Koparir A, Karatas OF, Yuceturk B, Yuksel B, Bayrak AO, Gerdan OF, Sagiroglu MS, Gezdirici A, Kirimtay K, Selcuk E, Karabay A, Creighton CJ, Yuksel A, Ozen M. Novel POC1A mutation in primordial dwarfism reveals new insights for centriole biogenesis. Human Molecular Genetics. 24: 5378-87. PMID 26162852 DOI: 10.1093/Hmg/Ddv261  0.328
2015 Feng S, Wang J, Zhang Y, Creighton CJ, Ittmann M. FGF23 promotes prostate cancer progression. Oncotarget. PMID 26019137 DOI: 10.18632/Oncotarget.4174  0.396
2015 Ozen M, Karatas OF, Gulluoglu S, Bayrak OF, Sevli S, Guzel E, Ekici ID, Caskurlu T, Solak M, Creighton CJ, Ittmann M. Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression. Cancer Investigation. 33: 251-8. PMID 25951106 DOI: 10.3109/07357907.2015.1025407  0.344
2015 Rathmell KW, Chen F, Creighton CJ. Genomics of chromophobe renal cell carcinoma: implications from a rare tumor for pan-cancer studies. Oncoscience. 2: 81-90. PMID 25859550 DOI: 10.18632/oncoscience.130  0.335
2015 Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee CS, Hsu D, Smith JL, Yuen G, Yue J, Ann DK, Simpson RM, Creighton CJ, Figg WD, Gucek M, et al. Oncogenesis driven by the Ras/Raf pathway requires the SUMO E2 ligase Ubc9. Proceedings of the National Academy of Sciences of the United States of America. 112: E1724-33. PMID 25805818 DOI: 10.1073/Pnas.1415569112  0.413
2015 Kundu ST, Byers LA, Peng DH, Roybal JD, Diao L, Wang J, Tong P, Creighton CJ, Gibbons DL. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. Oncogene. PMID 25798833 DOI: 10.1038/Onc.2015.71  0.398
2015 Farrugia MK, Sharma SB, Lin CC, McLaughlin SL, Vanderbilt DB, Ammer AG, Salkeni MA, Stoilov P, Agazie YM, Creighton CJ, Ruppert JM. Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer. Cell Death & Disease. 6: e1699. PMID 25789974 DOI: 10.1038/cddis.2015.65  0.369
2015 Liu J, Cho SN, Akkanti B, Jin N, Mao J, Long W, Chen T, Zhang Y, Tang X, Wistub II, Creighton CJ, Kheradmand F, DeMayo FJ. ErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis. Cell Reports. PMID 25753424 DOI: 10.1016/J.Celrep.2015.02.014  0.461
2015 Zhang L, Shao L, Creighton CJ, Zhang Y, Xin L, Ittmann M, Wang J. Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis. Oncotarget. 6: 6281-94. PMID 25749044 DOI: 10.18632/Oncotarget.3366  0.356
2015 Mishra DK, Creighton CJ, Zhang Y, Chen F, Thrall MJ, Kim MP. Ex vivo four-dimensional lung cancer model mimics metastasis. The Annals of Thoracic Surgery. 99: 1149-56. PMID 25701100 DOI: 10.1016/J.Athoracsur.2014.08.085  0.359
2015 Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, ... ... Creighton CJ, et al. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. The Journal of Clinical Investigation. 125: 1147-62. PMID 25664850 DOI: 10.1172/Jci74725  0.388
2015 Roarty K, Shore AN, Creighton CJ, Rosen JM. Ror2 regulates branching, differentiation, and actin-cytoskeletal dynamics within the mammary epithelium. The Journal of Cell Biology. 208: 351-66. PMID 25624393 DOI: 10.1083/Jcb.201408058  0.351
2015 Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, et al. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. PMID 25579177 DOI: 10.1038/Onc.2014.429  0.437
2015 Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki LE, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, et al. Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis. Breast Cancer Research : Bcr. 17: 3. PMID 25572662 DOI: 10.1186/S13058-014-0508-5  0.43
2015 Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 26: 57-79. PMID 25552398 DOI: 10.1007/S00335-014-9551-X  0.356
2015 Addison JB, Koontz C, Fugett JH, Creighton CJ, Chen D, Farrugia MK, Padon RR, Voronkova MA, McLaughlin SL, Livengood RH, Lin CC, Ruppert JM, Pugacheva EN, Ivanov AV. KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Research. 75: 344-55. PMID 25421577 DOI: 10.1158/0008-5472.Can-14-1561  0.476
2015 Quintás-Cardama A, Zhang N, Qiu YH, Post S, Creighton CJ, Cortes J, Coombes KR, Kornblau SM. Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia. Clinical Lymphoma, Myeloma & Leukemia. 15: 115-127.e15. PMID 25248926 DOI: 10.1016/J.Clml.2014.07.011  0.348
2015 Zhao D, Pan C, Sun J, Gilbert C, Drews-Elger K, Azzam DJ, Picon-Ruiz M, Kim M, Ullmer W, El-Ashry D, Creighton CJ, Slingerland JM. VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2. Oncogene. 34: 3107-19. PMID 25151964 DOI: 10.1038/Onc.2014.257  0.403
2015 Guzel E, Karatas OF, Semercioz A, Ekici S, Aykan S, Yentur S, Creighton CJ, Ittmann M, Ozen M. Identification of microRNAs differentially expressed in prostatic secretions of patients with prostate cancer. International Journal of Cancer. Journal International Du Cancer. 136: 875-9. PMID 24976077 DOI: 10.1002/Ijc.29054  0.329
2015 Bharadwaj U, Eckols TK, Kolosov M, Kasembeli MM, Adam A, Torres D, Zhang X, Dobrolecki LE, Wei W, Lewis MT, Dave B, Chang JC, Landis MD, Creighton CJ, Mancini MA, et al. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene. 34: 1341-53. PMID 24681959 DOI: 10.1038/Onc.2014.72  0.458
2015 Albiges L, Murray B, Brooks A, Cherniack A, Berger A, Creighton CJ, Ricketts C, Bottaro DP, Srinivasan R, Schmidt LS, Meyerson M, Spellman P, Linehan WM, Choueiri TK. Distinct MET alterations to induce a common phenotype and to define a MET-driven subset of papillary RCC: Results from the Cancer Genome Atlas (TCGA) Kidney Renal Papillary (KIRP) Working Group. Journal of Clinical Oncology. 33: 4521-4521. DOI: 10.1200/Jco.2015.33.15_Suppl.4521  0.369
2015 Fu X, Jeselsohn R, Hollingsworth EF, Lopez-Terrada D, Creighton CJ, Nardone A, Shea M, Heiser LM, Anur P, Wang N, Grasso C, Spellman P, Gutierrez C, Rimawi MF, Hilsenbeck SG, et al. Abstract PD6-2: FoxA1 gene amplification in ER+ breast cancer mediates endocrine resistance by increasing IL-8 Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-Pd6-2  0.412
2015 Westbrook TF, Nair A, Sun T, Karlin KL, Kessler J, Migliaccio I, Nguyen DX, Bernardi RJ, Renwick A, Creighton CJ, Dephoure N, Gygi SP, Shaw CA, Gibbs R, Wheeler D, et al. Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P6-11-01  0.458
2015 Giuliano M, Herrera S, Christiny P, Shaw C, Creighton CJ, Mitchell T, Bhat R, Zhang X, Mao S, Dobrolecki L, Al-rawi A, Chen F, Veneziani BM, Zhang XH, Hilsenbeck SG, et al. Abstract P4-01-06: Circulating and disseminated tumor cells from breast cancer patient-derived xenograft-bearing mice as a novel model to study metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P4-01-06  0.443
2015 Qin L, Hahn MB, Fu X, Shea MJ, Giuliano M, Nanda S, Xu X, Hu H, Jung SY, Heiser LM, Wang N, Gray JW, Hilsenbeck SG, Creighton C, Shaw CA, et al. Abstract P3-05-13: Overexpression of insulin receptor substrate 4 can mediate acquired resistance to lapatinib-containing regimens in HER2+ breast cancer cells Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P3-05-13  0.396
2015 Park JH, Kumar S, Vithayathil S, Arora K, Putluri N, Tsouko E, Donti TR, Frigo DE, Creighton CJ, Lewis MT, Sreekumar A, Wong L, Kaipparettu BA. Abstract P1-07-06: Activation of oncogenic pathways by mitochondrial reprogramming in triple negative breast cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-07-06  0.474
2015 Midorikawa Y, Yamamoto S, Tatsuno K, Ueda H, Tsuji S, Nagae G, Sonoda K, Shibata T, Covington KR, Creighton CJ, Sugitani M, Wheeler DA, Takayama T, Aburatani H. Abstract 958: Early hepatocellular carcinoma as another entity from classical hepatocellular carcinoma by integrated genomic analysis Cancer Research. 75: 958-958. DOI: 10.1158/1538-7445.Am2015-958  0.303
2015 Park JH, Vithayathil SA, Putluri N, Tsouko E, Donti TR, Frigo DE, Creighton CJ, Lewis MT, Sreekumar A, Wong L, Kaipparettu BA. Abstract 3055: Regulation of mitochondria-nuclear crosstalk in triple negative breast cancer Cancer Research. 75: 3055-3055. DOI: 10.1158/1538-7445.Am2015-3055  0.477
2015 Weinstein JN, Kim J, Creighton CJ, Akbani R, Hoadley KA, Kim WY, Morgan MB, Hinoue T, Cherniack A, Su X, Mungall AJ, Ryan MC, Bajorin DF, Rosenberg JE, Czerniak B, et al. Abstract 2969: Progress in The Cancer Genome Atlas bladder cancer project Cancer Research. 75: 2969-2969. DOI: 10.1158/1538-7445.Am2015-2969  0.366
2015 Liu J, Cho S, Zhang Y, Creighton CJ, DeMayo FJ. Abstract 2308: The role of LKB1 in development of lung squamous cell carcinoma in mice Cancer Research. 75: 2308-2308. DOI: 10.1158/1538-7445.Am2015-2308  0.38
2015 Zheng Z, Bu W, Tian L, Fan C, Gao X, Yu C, Jun L, Zhang X, Liao Y, Li Y, Lewis MT, Edwards D, Hilsenbeck SG, Medina D, Zwaka TP, ... ... Creighton CJ, et al. Abstract 2139: Wild type N-Ras, overexpressed in basal-like breast cancer, promotes tumor formation by inducing IL8 secretion via JAK2 activation Molecular and Cellular Biology. DOI: 10.1158/1538-7445.Am2015-2139  0.373
2015 Lu H, Pantazi A, Dogruluk T, Dogruluk A, Creighton C, Mills GB, Kucherlapati R, Scott KL. Abstract 1099: High-throughput engineering and functional annotation of cancer fusion genes Cancer Research. 75: 1099-1099. DOI: 10.1158/1538-7445.Am2015-1099  0.345
2015 Qi Y, Kai K, Creighton CJ, Eckhardt B, Saya H, Tripathy D, Ueno NT. Abstract 1078: TGF-β and TNF-α activate gene transcription programs associated with poor breast cancer prognosis Cancer Research. 75: 1078-1078. DOI: 10.1158/1538-7445.Am2015-1078  0.43
2014 Totoki Y, Tatsuno K, Covington KR, Ueda H, Creighton CJ, Kato M, Tsuji S, Donehower LA, Slagle BL, Nakamura H, Yamamoto S, Shinbrot E, Hama N, Lehmkuhl M, Hosoda F, et al. Trans-ancestry mutational landscape of hepatocellular carcinoma genomes. Nature Genetics. 46: 1267-73. PMID 25362482 DOI: 10.1038/Ng.3126  0.339
2014 Yang F, Chen Y, Shen T, Guo D, Dakhova O, Ittmann MM, Creighton CJ, Zhang Y, Dang TD, Rowley DR. Stromal TGF-β signaling induces AR activation in prostate cancer. Oncotarget. 5: 10854-69. PMID 25333263 DOI: 10.18632/Oncotarget.2536  0.344
2014 Qin J, Lee HJ, Wu SP, Lin SC, Lanz RB, Creighton CJ, DeMayo FJ, Tsai SY, Tsai MJ. Androgen deprivation-induced NCoA2 promotes metastatic and castration-resistant prostate cancer. The Journal of Clinical Investigation. 124: 5013-26. PMID 25295534 DOI: 10.1172/Jci76412  0.406
2014 Yu Z, Kim J, He L, Creighton CJ, Gunaratne PH, Hawkins SM, Matzuk MM. Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. Biology of Reproduction. 91: 113. PMID 25273528 DOI: 10.1095/Biolreprod.114.121988  0.402
2014 Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, et al. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Research : Bcr. 16: 430. PMID 25212826 DOI: 10.1186/S13058-014-0430-X  0.382
2014 Davis CF, Ricketts CJ, Wang M, Yang L, Cherniack AD, Shen H, Buhay C, Kang H, Kim SC, Fahey CC, Hacker KE, Bhanot G, Gordenin DA, Chu A, Gunaratne PH, ... ... Creighton CJ, et al. The somatic genomic landscape of chromophobe renal cell carcinoma. Cancer Cell. 26: 319-30. PMID 25155756 DOI: 10.1016/J.Ccr.2014.07.014  0.389
2014 Kwon OJ, Valdez JM, Zhang L, Zhang B, Wei X, Su Q, Ittmann MM, Creighton CJ, Xin L. Increased Notch signalling inhibits anoikis and stimulates proliferation of prostate luminal epithelial cells. Nature Communications. 5: 4416. PMID 25048699 DOI: 10.1038/Ncomms5416  0.367
2014 Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, et al. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia (New York, N.Y.). 16: 390-402. PMID 25016594 DOI: 10.1016/J.Neo.2014.05.007  0.452
2014 Karatas OF, Guzel E, Suer I, Ekici ID, Caskurlu T, Creighton CJ, Ittmann M, Ozen M. miR-1 and miR-133b are differentially expressed in patients with recurrent prostate cancer. Plos One. 9: e98675. PMID 24967583 DOI: 10.1371/Journal.Pone.0098675  0.323
2014 Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. Plos Genetics. 10: e1004451. PMID 24945252 DOI: 10.1371/Journal.Pgen.1004451  0.364
2014 Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, et al. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Research. 24: 809-19. PMID 24874954 DOI: 10.1038/Cr.2014.71  0.431
2014 Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. The Journal of Clinical Investigation. 124: 2696-708. PMID 24762440 DOI: 10.1172/Jci72171  0.427
2014 Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JP. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biology of Reproduction. 90: 75. PMID 24571987 DOI: 10.1095/Biolreprod.114.117531  0.373
2014 Liu S, Lai L, Zuo Q, Dai F, Wu L, Wang Y, Zhou Q, Liu J, Liu J, Li L, Lin Q, Creighton CJ, Costello MG, Huang S, Jia C, et al. PKA turnover by the REGγ-proteasome modulates FoxO1 cellular activity and VEGF-induced angiogenesis. Journal of Molecular and Cellular Cardiology. 72: 28-38. PMID 24560667 DOI: 10.1016/J.Yjmcc.2014.02.007  0.318
2014 Weinstein JN, Akbani R, Broom BM, Wang W, Verhaak RGW, McConkey D, Lerner S, Morgan M, Creighton CJ, Smith C, Cherniack AD, Kim J, Pedamallu CS, Noble MS, Al-Ahmadie HA, et al. Comprehensive molecular characterization of urothelial bladder carcinoma Nature. 507: 315-322. PMID 24476821 DOI: 10.1038/Nature12965  0.424
2014 Parikh N, Hilsenbeck S, Creighton CJ, Dayaram T, Shuck R, Shinbrot E, Xi L, Gibbs RA, Wheeler DA, Donehower LA. Effects of TP53 mutational status on gene expression patterns across 10 human cancer types. The Journal of Pathology. 232: 522-33. PMID 24374933 DOI: 10.1002/Path.4321  0.433
2014 Geldres C, Savoldo B, Hoyos V, Caruana I, Zhang M, Yvon E, Del Vecchio M, Creighton CJ, Ittmann M, Ferrone S, Dotti G. T lymphocytes redirected against the chondroitin sulfate proteoglycan-4 control the growth of multiple solid tumors both in vitro and in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 962-71. PMID 24334762 DOI: 10.1158/1078-0432.Ccr-13-2218  0.36
2014 Carstens JL, Shahi P, Van Tsang S, Smith B, Creighton CJ, Zhang Y, Seamans A, Seethammagari M, Vedula I, Levitt JM, Ittmann MM, Rowley DR, Spencer DM. FGFR1-WNT-TGF-β signaling in prostate cancer mouse models recapitulates human reactive stroma. Cancer Research. 74: 609-20. PMID 24305876 DOI: 10.1158/0008-5472.Can-13-1093  0.367
2014 Zhang P, Garnett J, Creighton CJ, Al Sannaa GA, Igram DR, Lazar A, Liu X, Liu C, Pollock RE. EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. The Journal of Pathology. 232: 308-18. PMID 24132643 DOI: 10.1002/Path.4294  0.358
2014 Fan Y, Ge N, Wang X, Sun W, Mao R, Bu W, Creighton CJ, Zheng P, Vasudevan S, An L, Yang J, Zhao YJ, Zhang H, Li XN, Rao PH, et al. Amplification and over-expression of MAP3K3 gene in human breast cancer promotes formation and survival of breast cancer cells. The Journal of Pathology. 232: 75-86. PMID 24122835 DOI: 10.1002/Path.4283  0.437
2014 Mishra DK, Creighton CJ, Zhang Y, Gibbons DL, Kurie JM, Kim MP. Gene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients. International Journal of Cancer. Journal International Du Cancer. 134: 789-98. PMID 23934967 DOI: 10.1002/Ijc.28428  0.389
2014 Zhang B, Chen H, Zhang L, Dakhova O, Zhang Y, Lewis MT, Creighton CJ, Ittmann MM, Xin L. A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis. Oncogene. 33: 3099-108. PMID 23851498 DOI: 10.1038/Onc.2013.281  0.475
2014 Wardwell-Ozgo J, Dogruluk T, Gifford A, Zhang Y, Heffernan TP, van Doorn R, Creighton CJ, Chin L, Scott KL. HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome. Oncogene. 33: 1017-26. PMID 23435427 DOI: 10.1038/Onc.2013.30  0.356
2014 Weinstein JN, Kim J, Creighton CJ, Akbani R, Hoadley KA, Kim WY, Morgan MB, Hinoue T, Rosenberg JE, Bajorin DF, Hansel DE, Al-Ahmadie H, Gordenin D, Stuart JM, Robertson G, et al. Comprehensive molecular profiling of urothelial bladder cancer at the DNA, RNA, and protein levels: A TCGA project. Journal of Clinical Oncology. 32: 4509-4509. DOI: 10.1200/Jco.2014.32.15_Suppl.4509  0.42
2014 Yu B, Swatkoski S, Holly A, Lee LC, Giroux V, Lee C, Carver J, Creighton C, Ann DK, Figg WD, Gucek M, Luo J. Abstract B29: A critical role of the SUMO pathway in KRAS-driven oncogenesis Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B29  0.393
2014 Addison J, Koontz C, McLaughlin S, Livengood R, Pugacheva E, Chen D, Creighton C, Ivanov AV. Abstract LB-2: TRIM28 is overexpressed in breast cancer and regulates the expression of multiple cancer-associated genes Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-2  0.494
2014 Weinstein JN, Kim J, Creighton CJ, Akbani R, Hoadley KA, Kim WY, Morgan MB, Hinoue T, Cherniack A, Su X, Mungall AJ, Ryan MC, Rosenberg JE, Bajorin DF, Czerniak B, et al. Abstract 987: Comprehensive characterization of urothelial bladder cancer: a TCGA Project update Cancer Research. 74: 987-987. DOI: 10.1158/1538-7445.Am2014-987  0.46
2014 Anderson ML, Kim GE, Mach CM, Creighton CJ, Lev D. Abstract 5242: miR-10b functions as a novel tumor suppressor in uterine leiomyosarcoma by promoting overexpression of SDC1 Cancer Research. 74: 5242-5242. DOI: 10.1158/1538-7445.Am2014-5242  0.362
2014 Park J, Arora K, Vithayathil SA, Donti TR, Creighton C, Lewis MT, Sreekumar A, Wong L, Kaipparettu BA. Abstract 4327: Mitochondrial reprogramming in triple negative breast cancer progression Cancer Research. 74: 4327-4327. DOI: 10.1158/1538-7445.Am2014-4327  0.453
2014 Covington KR, Donehower LA, Creighton C, Slagle BL, Goss JA, Cotton RT, Gingras M, Shinbrot E, Guiteau JJ, Nguyen TN, Harring TR, Muzny DM, Walker K, Doddapaneni H, Gibbs RA, et al. Abstract 2211: Viral subtypes in hepatocellular carcinoma are associated with different mechanisms of WNT/CTNNB1 alteration Cancer Research. 74: 2211-2211. DOI: 10.1158/1538-7445.Am2014-2211  0.303
2014 Kim M, Mishra D, Thrall M, Creighton C, Gibbons D, Kurie J, Kim M. A549 and H1299 Cells Form Metastatic Lesions in the Ex Vivo 4D Lung Cancer Model Journal of Surgical Research. 186: 557-558. DOI: 10.1016/J.Jss.2013.11.469  0.314
2013 Creighton CJ. Widespread molecular patterns associated with drug sensitivity in breast cancer cell lines, with implications for human tumors. Plos One. 8: e71158. PMID 24386073 DOI: 10.1371/Journal.Pone.0071158  0.425
2013 Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. Plos Genetics. 9: e1003863. PMID 24244176 DOI: 10.1371/Journal.Pgen.1003863  0.337
2013 Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. Plos Genetics. 9: e1003900. PMID 24204309 DOI: 10.1371/Journal.Pgen.1003900  0.364
2013 Li X, Large MJ, Creighton CJ, Lanz RB, Jeong JW, Young SL, Lessey BA, Palomino WA, Tsai SY, Demayo FJ. COUP-TFII regulates human endometrial stromal genes involved in inflammation. Molecular Endocrinology (Baltimore, Md.). 27: 2041-54. PMID 24176914 DOI: 10.1210/Me.2013-1191  0.384
2013 Atkinson RL, Yang WT, Rosen DG, Landis MD, Wong H, Lewis MT, Creighton CJ, Sexton KR, Hilsenbeck SG, Sahin AA, Brewster AM, Woodward WA, Chang JC. Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency. Breast Cancer Research : Bcr. 15: R77. PMID 24008095 DOI: 10.1186/Bcr3471  0.409
2013 Creighton CJ, Gibbons DL, Kurie JM. The role of epithelial-mesenchymal transition programming in invasion and metastasis: a clinical perspective. Cancer Management and Research. 5: 187-95. PMID 23986650 DOI: 10.2147/Cmar.S35171  0.502
2013 Peng S, Creighton CJ, Zhang Y, Sen B, Mazumdar T, Myers JN, Lai SY, Woolfson A, Lorenzi MV, Bell D, Williams MD, Johnson FM. Tumor grafts derived from patients with head and neck squamous carcinoma authentically maintain the molecular and histologic characteristics of human cancers. Journal of Translational Medicine. 11: 198. PMID 23981300 DOI: 10.1186/1479-5876-11-198  0.359
2013 Abazeed ME, Adams DJ, Hurov KE, Tamayo P, Creighton CJ, Sonkin D, Giacomelli AO, Du C, Fries DF, Wong KK, Mesirov JP, Loeffler JS, Schreiber SL, Hammerman PS, Meyerson M. Integrative radiogenomic profiling of squamous cell lung cancer. Cancer Research. 73: 6289-98. PMID 23980093 DOI: 10.1158/0008-5472.Can-13-1616  0.38
2013 Lain AR, Creighton CJ, Conneely OM. Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis. Molecular Endocrinology (Baltimore, Md.). 27: 1743-61. PMID 23979845 DOI: 10.1210/Me.2013-1144  0.374
2013 Bayrak OF, Gulluoglu S, Aydemir E, Ture U, Acar H, Atalay B, Demir Z, Sevli S, Creighton CJ, Ittmann M, Sahin F, Ozen M. MicroRNA expression profiling reveals the potential function of microRNA-31 in chordomas. Journal of Neuro-Oncology. 115: 143-51. PMID 23912551 DOI: 10.1007/S11060-013-1211-6  0.317
2013 Kaipparettu BA, Ma Y, Park JH, Lee TL, Zhang Y, Yotnda P, Creighton CJ, Chan WY, Wong LJ. Crosstalk from non-cancerous mitochondria can inhibit tumor properties of metastatic cells by suppressing oncogenic pathways. Plos One. 8: e61747. PMID 23671572 DOI: 10.1371/Journal.Pone.0061747  0.415
2013 Mach CM, Kim J, Soibam B, Creighton CJ, Hawkins SM, Zighelboim I, Goodfellow P, Gunaratne PH, Odunsi K, Salem PA, Anderson ML. Novel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas. Cancer Letters. 335: 314-22. PMID 23454583 DOI: 10.1016/J.Canlet.2013.02.043  0.338
2013 Feng S, Dakhova O, Creighton CJ, Ittmann M. Endocrine fibroblast growth factor FGF19 promotes prostate cancer progression. Cancer Research. 73: 2551-62. PMID 23440425 DOI: 10.1158/0008-5472.Can-12-4108  0.392
2013 Mo W, Chen J, Patel A, Zhang L, Chau V, Li Y, Cho W, Lim K, Xu J, Lazar AJ, Creighton CJ, Bolshakov S, McKay RM, Lev D, Le LQ, et al. CXCR4/CXCL12 mediate autocrine cell- cycle progression in NF1-associated malignant peripheral nerve sheath tumors. Cell. 152: 1077-90. PMID 23434321 DOI: 10.1016/J.Cell.2013.01.053  0.378
2013 Wander SA, Zhao D, Besser AH, Hong F, Wei J, Ince TA, Milikowski C, Bishopric NH, Minn AJ, Creighton CJ, Slingerland JM. PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Research and Treatment. 138: 369-81. PMID 23430223 DOI: 10.1007/S10549-012-2389-6  0.443
2013 Hoffman A, Ghadimi MP, Demicco EG, Creighton CJ, Torres K, Colombo C, Peng T, Lusby K, Ingram D, Hornick JL, Wang WL, Ravi V, Lazar AJ, Lev D, Pollock RE. Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. Cancer. 119: 1868-77. PMID 23401071 DOI: 10.1002/Cncr.27847  0.303
2013 Lusby K, Savannah KB, Demicco EG, Zhang Y, Ghadimi MP, Young ED, Colombo C, Lam R, Dogan TE, Hornick JL, Lazar AJ, Hunt KK, Anderson ML, Creighton CJ, Lev D, et al. Uterine leiomyosarcoma management, outcome, and associated molecular biomarkers: a single institution's experience. Annals of Surgical Oncology. 20: 2364-72. PMID 23334251 DOI: 10.1245/S10434-012-2834-0  0.367
2013 Verhaak RG, Tamayo P, Yang JY, Hubbard D, Zhang H, Creighton CJ, Fereday S, Lawrence M, Carter SL, Mermel CH, Kostic AD, Etemadmoghadam D, Saksena G, Cibulskis K, Duraisamy S, et al. Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. The Journal of Clinical Investigation. 123: 517-25. PMID 23257362 DOI: 10.1172/Jci65833  0.37
2013 Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY. COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis. Nature. 493: 236-40. PMID 23201680 DOI: 10.1038/Nature11674  0.374
2013 Donehower LA, Creighton CJ, Schultz N, Shinbrot E, Chang K, Gunaratne PH, Muzny D, Sander C, Hamilton SR, Gibbs RA, Wheeler D. MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. The Journal of Pathology. 229: 99-110. PMID 22899370 DOI: 10.1002/Path.4087  0.325
2013 Wardwell-Ozgo J, Dogruluk T, Gifford A, zhang Y, Doorn Rv, Creighton C, Scott K. Abstract 3881: HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome. Cancer Research. 73: 3881-3881. DOI: 10.1158/1538-7445.Am2013-3881  0.357
2013 Peng S, Creighton C, Zhang Y, Sen B, Mazumdar T, Myers J, Bell D, El-Naggar A, Williams M, Johnson F. Abstract 333: Molecular and histologic characterization a patient-derived heterotransplant mouse model of head and neck squamous carcinoma. Cancer Research. 73: 333-333. DOI: 10.1158/1538-7445.Am2013-333  0.427
2013 Kumar S, Gupta V, Vithayathil S, Park J, Donti TR, Creighton CJ, Lewis MT, Sreekumar A, Wong L, Kaipparettu BA. Abstract 1696: Mitochondria-nuclear cross talk regulate cancer properties by activating oncogenic pathways. Cancer Research. 73: 1696-1696. DOI: 10.1158/1538-7445.Am2013-1696  0.422
2013 Mishra DK, Creighton C, Zhang Y, Gibbons DL, Kurie JM, Kim MP. Abstract 1508: Gene expression analysis of perfusable nodules grown onex vivo3D model shows effects on extracellular matrix, cell signaling and immune response. Cancer Research. 73: 1508-1508. DOI: 10.1158/1538-7445.Am2013-1508  0.398
2013 Chakravarti D, Su X, Cho M, Gi YJ, Benham A, Coarfa C, Venkatanarayan A, Alana J, Creighton C, Xiao w, Leung M, Vin H, Chan IL, Aquino A, Müller N, et al. Abstract 1119: Induced pluripotency in adult keratinocytes through downregulation of ΔNp63 or DGCR8. Cancer Research. 73: 1119-1119. DOI: 10.1158/1538-7445.Am2013-1119  0.372
2013 Trivedi M, Bhat R, Yadav V, Yadav P, Al-Rawi A, Christiny P, Nanda S, Giuliano M, Creighton C, Osborne C, Narkar V, Schiff R. Abstract P6-04-05: GPR110 overexpression increases tumorigenic potential of HER2+ breast cancer cells Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-P6-04-05  0.453
2012 Creighton CJ. Using large-scale molecular data sets to improve breast cancer treatment. Breast Cancer Management. 1: 57-64. PMID 23869198 DOI: 10.2217/Bmt.12.14  0.415
2012 Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, et al. Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 109: E3659-67. PMID 23236152 DOI: 10.1073/Pnas.1207673110  0.448
2012 Valdez JM, Zhang L, Su Q, Dakhova O, Zhang Y, Shahi P, Spencer DM, Creighton CJ, Ittmann MM, Xin L. Notch and TGFβ form a reciprocal positive regulatory loop that suppresses murine prostate basal stem/progenitor cell activity. Cell Stem Cell. 11: 676-88. PMID 23122291 DOI: 10.1016/J.Stem.2012.07.003  0.334
2012 Creighton CJ. Molecular classification and drug response prediction in cancer. Current Drug Targets. 13: 1488-94. PMID 22974392 DOI: 10.2174/138945012803530143  0.402
2012 Creighton CJ. The molecular profile of luminal B breast cancer. Biologics : Targets & Therapy. 6: 289-97. PMID 22956860 DOI: 10.2147/Btt.S29923  0.456
2012 Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. Plos Genetics. 8: e1002840. PMID 22911650 DOI: 10.1371/Journal.Pgen.1002840  0.341
2012 Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. The Journal of Clinical Investigation. 122: 3170-83. PMID 22850877 DOI: 10.1172/Jci63608  0.384
2012 Brewer Savannah KJ, Demicco EG, Lusby K, Ghadimi MP, Belousov R, Young E, Zhang Y, Huang KL, Lazar AJ, Hunt KK, Pollock RE, Creighton CJ, Anderson ML, Lev D. Dual targeting of mTOR and aurora-A kinase for the treatment of uterine Leiomyosarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 4633-45. PMID 22821997 DOI: 10.1158/1078-0432.Ccr-12-0436  0.383
2012 Muzny DM, Bainbridge MN, Chang K, Dinh HH, Drummond JA, Fowler G, Kovar CL, Lewis LR, Morgan MB, Newsham IF, Reid JG, Santibanez J, Shinbrot E, Trevino LR, Wu YQ, ... ... Creighton CJ, et al. Comprehensive molecular characterization of human colon and rectal cancer Nature. 487: 330-337. PMID 22810696 DOI: 10.1038/Nature11252  0.397
2012 Hawkins SM, Andreu-Vieyra CV, Kim TH, Jeong JW, Hodgson MC, Chen R, Creighton CJ, Lydon JP, Gunaratne PH, DeMayo FJ, Matzuk MM. Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Molecular Endocrinology (Baltimore, Md.). 26: 1552-66. PMID 22798293 DOI: 10.1210/Me.2012-1042  0.346
2012 Chen AC, Migliaccio I, Rimawi M, Lopez-Tarruella S, Creighton CJ, Massarweh S, Huang C, Wang YC, Batra SK, Gutierrez MC, Osborne CK, Schiff R. Upregulation of mucin4 in ER-positive/HER2-overexpressing breast cancer xenografts with acquired resistance to endocrine and HER2-targeted therapies. Breast Cancer Research and Treatment. 134: 583-93. PMID 22644656 DOI: 10.1007/S10549-012-2082-9  0.406
2012 Xu J, Wan M, He Q, Bassett RL, Fu X, Chen AC, Shi F, Creighton CJ, Schiff R, Huo L, Liu D. SGK3 is associated with estrogen receptor expression in breast cancer. Breast Cancer Research and Treatment. 134: 531-41. PMID 22576469 DOI: 10.1007/S10549-012-2081-X  0.449
2012 Shan W, Akinfenwa PY, Savannah KB, Kolomeyevskaya N, Laucirica R, Thomas DG, Odunsi K, Creighton CJ, Lev DC, Anderson ML. A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 3352-65. PMID 22535157 DOI: 10.1158/1078-0432.Ccr-11-3058  0.403
2012 Creighton CJ, Hernandez-Herrera A, Jacobsen A, Levine DA, Mankoo P, Schultz N, Du Y, Zhang Y, Larsson E, Sheridan R, Xiao W, Spellman PT, Getz G, Wheeler DA, Perou CM, et al. Integrated analyses of microRNAs demonstrate their widespread influence on gene expression in high-grade serous ovarian carcinoma. Plos One. 7: e34546. PMID 22479643 DOI: 10.1371/Journal.Pone.0034546  0.352
2012 Ghadimi MP, Young ED, Belousov R, Zhang Y, Lopez G, Lusby K, Kivlin C, Demicco EG, Creighton CJ, Lazar AJ, Pollock RE, Lev D. Survivin is a viable target for the treatment of malignant peripheral nerve sheath tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2545-57. PMID 22407831 DOI: 10.1158/1078-0432.Ccr-11-2592  0.391
2012 Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM. High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proceedings of the National Academy of Sciences of the United States of America. 109: 3921-6. PMID 22331912 DOI: 10.1073/Pnas.1117135109  0.429
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Creighton CJ, et al. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (New York, N.Y.). 335: 348-53. PMID 22157079 DOI: 10.1126/Science.1212728  0.458
2012 Creighton CJ, Sada YH, Zhang Y, Tsimelzon A, Wong H, Dave B, Landis MD, Bear HD, Rodriguez A, Chang JC. A gene transcription signature of obesity in breast cancer. Breast Cancer Research and Treatment. 132: 993-1000. PMID 21750966 DOI: 10.1007/S10549-011-1595-Y  0.363
2012 Casa AJ, Potter AS, Malik S, Lazard Z, Kuiatse I, Kim HT, Tsimelzon A, Creighton CJ, Hilsenbeck SG, Brown PH, Oesterreich S, Lee AV. Estrogen and insulin-like growth factor-I (IGF-I) independently down-regulate critical repressors of breast cancer growth. Breast Cancer Research and Treatment. 132: 61-73. PMID 21541704 DOI: 10.1007/S10549-011-1540-0  0.435
2012 Shore AN, Kabotyanski EB, Roarty K, Smith MA, Zhang Y, Creighton CJ, Dinger ME, Rosen JM. Overexpression of mPINC inhibits differentiation of HC11 cells. Plos Genetics. DOI: 10.1371/Journal.Pgen.1002840.G005  0.323
2012 Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM. Abstract 4878: The fallopian tube is the origin of high-grade serous ovarian carcinomas in a mouse model Cancer Research. 72: 4878-4878. DOI: 10.1158/1538-7445.Am2012-4878  0.436
2012 Azzam DJ, Elger KD, Zhao D, Ranganathan P, Capobianco T, Minn AJ, Creighton C, Picon M, Sun J, Pan C, Wander SA, Ashry DE, Slingerland JM. Abstract 3478: CD44+CD24low+progenitors in ER negative breast cancer have higher Notch1 activation, self-renewal, and chemo resistance and generate CD44+CD24negcells and tumors that metastasize Cancer Research. 72: 3478-3478. DOI: 10.1158/1538-7445.Am2012-3478  0.34
2012 Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, ... ... Creighton C, et al. Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis Cancer Research. 72: 3091-3091. DOI: 10.1158/1538-7445.Am2012-3091  0.45
2012 Fu X, Kumar V, Shea M, Biswal N, Nanda S, Chayanam S, Mitchell T, Hergenroeder G, Meerbrey K, Joshi A, Westbrook T, Mills G, Creighton C, Hilsenbeck S, Osborne C, et al. Abstract PD01-01: Overcoming endocrine therapy resistance related to PTEN loss by strategic combinations with mTOR, AKT, or MEK inhibitors Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-Pd01-01  0.384
2012 Yadav P, Bhat R, Chayanam S, Christiny P, Nanda S, Hu H, Creighton C, Osborne C, Schiff R, Trivedi M. Abstract P4-06-02: Identification of novel G-protein coupled receptor targets in HER2-positive breast cancer. Cancer Research. 72. DOI: 10.1158/0008-5472.Sabcs12-P4-06-02  0.397
2012 Au JK, Florentin D, Ding Y, He D, Creighton CJ, Frolov A, Dakhova O, Zhang Y, Smith C, Kadmon D, Miles B, Ittmann M, Rowley D, Ayala G. 313 Influence Of The Neural Microenvironment In Prostate Cancer The Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.373  0.325
2012 Ayala G, Florentin D, Au JK, Ding Y, He D, Creighton CJ, Frolov A, Dakhova O, Zhang Y, Smith C, Kadmon D, Miles B, Ittmann M, Rowley D. 1633 TARGETING THE NEURAL MICROENVIRONMENT IN PROSTATE CANCER: A NEOADJUVANT BOTOX CLINICAL TRIAL Journal of Urology. 187. DOI: 10.1016/J.Juro.2012.02.1450  0.321
2011 Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JM. Stem cell antigen-1 (sca-1) regulates mammary tumor development and cell migration. Plos One. 6: e27841. PMID 22140470 DOI: 10.1371/Journal.Pone.0027841  0.428
2011 Dong J, Huang S, Caikovski M, Ji S, McGrath A, Custorio MG, Creighton CJ, Maliakkal P, Bogoslovskaia E, Du Z, Zhang X, Lewis MT, Sablitzky F, Brisken C, Li Y. ID4 regulates mammary gland development by suppressing p38MAPK activity. Development (Cambridge, England). 138: 5247-56. PMID 22069192 DOI: 10.1242/Dev.069203  0.385
2011 Schliekelman MJ, Gibbons DL, Faca VM, Creighton CJ, Rizvi ZH, Zhang Q, Wong CH, Wang H, Ungewiss C, Ahn YH, Shin DH, Kurie JM, Hanash SM. Targets of the tumor suppressor miR-200 in regulation of the epithelial-mesenchymal transition in cancer. Cancer Research. 71: 7670-82. PMID 21987723 DOI: 10.1158/0008-5472.Can-11-0964  0.407
2011 Ahn YH, Yang Y, Gibbons DL, Creighton CJ, Yang F, Wistuba II, Lin W, Thilaganathan N, Alvarez CA, Roybal J, Goldsmith EJ, Tournier C, Kurie JM. Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression. Molecular and Cellular Biology. 31: 4270-85. PMID 21896780 DOI: 10.1128/Mcb.05562-11  0.431
2011 Colombo C, Creighton CJ, Ghadimi MP, Bolshakov S, Warneke CL, Zhang Y, Lusby K, Zhu S, Lazar AJ, West RB, van de Rijn M, Lev D. Increased midkine expression correlates with desmoid tumour recurrence: a potential biomarker and therapeutic target. The Journal of Pathology. 225: 574-82. PMID 21826666 DOI: 10.1002/Path.2951  0.386
2011 Putluri N, Shojaie A, Vasu VT, Nalluri S, Vareed SK, Putluri V, Vivekanandan-Giri A, Byun J, Pennathur S, Sana TR, Fischer SM, Palapattu GS, Creighton CJ, Michailidis G, Sreekumar A. Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells. Plos One. 6: e21417. PMID 21789170 DOI: 10.1371/Journal.Pone.0021417  0.38
2011 Yu W, Feng S, Dakhova O, Creighton CJ, Cai Y, Wang J, Li R, Frolov A, Ayala G, Ittmann M. FGFR-4 Arg³⁸⁸ enhances prostate cancer progression via extracellular signal-related kinase and serum response factor signaling. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 4355-66. PMID 21622724 DOI: 10.1158/1078-0432.Ccr-10-2858  0.383
2011 Helland Ã…, Anglesio MS, George J, Cowin PA, Johnstone CN, House CM, Sheppard KE, Etemadmoghadam D, Melnyk N, Rustgi AK, Phillips WA, Johnsen H, Holm R, Kristensen GB, Birrer MJ, ... ... Creighton CJ, et al. Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers. Plos One. 6: e18064. PMID 21533284 DOI: 10.1371/Journal.Pone.0018064  0.432
2011 Bu W, Chen J, Morrison GD, Huang S, Creighton CJ, Huang J, Chamness GC, Hilsenbeck SG, Roop DR, Leavitt AD, Li Y. Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer Oncogene. 30: 4399-4409. PMID 21532625 DOI: 10.1038/Onc.2011.147  0.462
2011 Vareed SK, Bhat VB, Thompson C, Vasu VT, Fermin D, Choi H, Creighton CJ, Gayatri S, Lan L, Putluri N, Thangjam GS, Kaur P, Shabahang M, Giri JG, Nesvizhskii AI, et al. Metabolites of purine nucleoside phosphorylase (NP) in serum have the potential to delineate pancreatic adenocarcinoma. Plos One. 6: e17177. PMID 21448452 DOI: 10.1371/Journal.Pone.0017177  0.33
2011 Mullany LK, Fan HY, Liu Z, White LD, Marshall A, Gunaratne P, Anderson ML, Creighton CJ, Xin L, Deavers M, Wong KK, Richards JS. Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo. Oncogene. 30: 3522-36. PMID 21423204 DOI: 10.1038/Onc.2011.70  0.466
2011 Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganathan N, Alvarez CA, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JM. The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. The Journal of Clinical Investigation. 121: 1373-85. PMID 21403400 DOI: 10.1172/Jci42579  0.384
2011 Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, ... ... Creighton CJ, et al. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 144: 703-18. PMID 21376233 DOI: 10.1016/J.Cell.2011.02.003  0.432
2011 Litzenburger BC, Creighton CJ, Tsimelzon A, Chan BT, Hilsenbeck SG, Wang T, Carboni JM, Gottardis MM, Huang F, Chang JC, Lewis MT, Rimawi MF, Lee AV. High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2314-27. PMID 21177763 DOI: 10.1158/1078-0432.Ccr-10-1903  0.403
2011 Roybal JD, Zang Y, Ahn YH, Yang Y, Gibbons DL, Baird BN, Alvarez C, Thilaganathan N, Liu DD, Saintigny P, Heymach JV, Creighton CJ, Kurie JM. miR-200 Inhibits lung adenocarcinoma cell invasion and metastasis by targeting Flt1/VEGFR1. Molecular Cancer Research : McR. 9: 25-35. PMID 21115742 DOI: 10.1158/1541-7786.Mcr-10-0497  0.403
2011 Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 30: 724-36. PMID 20890303 DOI: 10.1038/Onc.2010.445  0.336
2011 Quintás-Cardama A, Qiu YH, Post S, Zhang Y, Creighton C, Cortes JE, Kornblau SM. Proteomic Profiling of 112 Proteins in Chronic Myeloid Leukemia Patient Samples Using Reverse Phase Proteins Arrays (RPPA) Reveals Distinct Protein Expression Signatures Associated with Advanced Phase Disease and the CD34+ Compartment Blood. 118: 2503-2503. DOI: 10.1182/Blood.V118.21.2503.2503  0.325
2011 Atkinson RL, Yang WT, Landis MD, Wong H, Creighton C, Hilsenbeck SG, Lewis MT, Woodward WA, Brewster A, Sahin AA, Chang JC. Abstract LB-106: Expression of stem cell biomarkers in benign breast tissue from patients with triple negative breast cancer Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-106  0.424
2011 Fu X, Nanda S, Gillihan RM, Shea M, Creighton CJ, Hilsenbeck SG, Lee AV, Schiff R, Osborne KC. Abstract 2290: Crosstalk between ER and PI3K signaling pathways in human luminal type breast cancer and its therapeutic implications Cancer Research. 71: 2290-2290. DOI: 10.1158/1538-7445.Am2011-2290  0.417
2011 Creighton C. SR2-3: Integrative Genomic Analyses of Breast Cancer from The Cancer Genome Atlas (TCGA). Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-Sr2-3  0.477
2011 Malorni L, Giuliano M, Migliaccio I, Wang T, Creighton C, Lupien M, Hilsenbeck S, Healy N, Mazumdar A, Trivedi M, Jeselsohn R, He H, Fu X, Gutierrez C, Brown M, et al. P4-01-18: AP-1 Blockade Potentiates the Anti-Tumor Effect of Endocrine Treatment and Reverts the Resistant Phenotype in Hormone Receptor-Positive Breast Cancer. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P4-01-18  0.39
2011 Healy N, Creighton C, Fu X, Tsimelzon A, Hilsenbeck S, Miller N, Kerin M, Osborne C, Schiff R. P3-03-05: Identification of miRNAs and Their Associated Target Genes Involved in Endocrine Resistance in Breast Cancer. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-P3-03-05  0.396
2011 Mach C, Kim J, Creighton C, Gunaratne P, Anderson M. A unique microRNA locus at 19q13.41 sensitizes epithelial ovarian cancers to chemotherapy Gynecologic Oncology. 120. DOI: 10.1016/J.Ygyno.2010.12.016  0.35
2010 Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. 467: 986-90. PMID 20962848 DOI: 10.1038/Nature09459  0.337
2010 Feng S, Agoulnik IU, Truong A, Li Z, Creighton CJ, Kaftanovskaya EM, Pereira R, Han HD, Lopez-Berestein G, Klonisch T, Ittmann MM, Sood AK, Agoulnik AI. Suppression of relaxin receptor RXFP1 decreases prostate cancer growth and metastasis. Endocrine-Related Cancer. 17: 1021-33. PMID 20861284 DOI: 10.1677/Erc-10-0073  0.455
2010 Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Research : Bcr. 12: R40. PMID 20569503 DOI: 10.1186/Bcr2594  0.391
2010 Pond AC, Herschkowitz JI, Schwertfeger KL, Welm B, Zhang Y, York B, Cardiff RD, Hilsenbeck S, Perou CM, Creighton CJ, Lloyd RE, Rosen JM. Fibroblast growth factor receptor signaling dramatically accelerates tumorigenesis and enhances oncoprotein translation in the mouse mammary tumor virus-Wnt-1 mouse model of breast cancer. Cancer Research. 70: 4868-79. PMID 20501844 DOI: 10.1158/0008-5472.Can-09-4404  0.445
2010 Monaco ME, Creighton CJ, Lee P, Zou X, Topham MK, Stafforini DM. Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity. Translational Oncology. 3: 91-8. PMID 20360933 DOI: 10.1593/Tlo.09202  0.434
2010 Creighton CJ, Chang JC, Rosen JM. Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. Journal of Mammary Gland Biology and Neoplasia. 15: 253-60. PMID 20354771 DOI: 10.1007/S10911-010-9173-1  0.49
2010 Creighton CJ, Fountain MD, Yu Z, Nagaraja AK, Zhu H, Khan M, Olokpa E, Zariff A, Gunaratne PH, Matzuk MM, Anderson ML. Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. Cancer Research. 70: 1906-15. PMID 20179198 DOI: 10.1158/0008-5472.Can-09-3875  0.434
2010 Franco HL, Lee KY, Rubel CA, Creighton CJ, White LD, Broaddus RR, Lewis MT, Lydon JP, Jeong JW, DeMayo FJ. Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse Biology of Reproduction. 82: 991-999. PMID 20130264 DOI: 10.1095/Biolreprod.109.081513  0.306
2010 Nagaraja AK, Creighton CJ, Yu Z, Zhu H, Gunaratne PH, Reid JG, Olokpa E, Itamochi H, Ueno NT, Hawkins SM, Anderson ML, Matzuk MM. A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Molecular Endocrinology (Baltimore, Md.). 24: 447-63. PMID 20081105 DOI: 10.1210/Me.2009-0295  0.432
2010 LaMarca HL, Visbal AP, Creighton CJ, Liu H, Zhang Y, Behbod F, Rosen JM. CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells (Dayton, Ohio). 28: 535-44. PMID 20054865 DOI: 10.1002/Stem.297  0.379
2010 Hammerich-Hille S, Kaipparettu BA, Tsimelzon A, Creighton CJ, Jiang S, Polo JM, Melnick A, Meyer R, Oesterreich S. SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells. The Journal of Biological Chemistry. 285: 3608-16. PMID 19901029 DOI: 10.1074/Jbc.M109.066431  0.4
2010 Zhang L, Zhao W, Valdez JM, Creighton CJ, Xin L. Low-density taqman miRNA array reveals miRNAs differentially expressed in prostatic stem cells and luminal cells Prostate. 70: 297-304. PMID 19827049 DOI: 10.1002/Pros.21064  0.331
2010 Pond AC, Herschkowitz JI, Hilsenbeck S, Creighton C, Lloyd RE, Rosen JM. Abstract 282: FGF receptor signaling accelerates Wnt-1 mammary tumorigenesis and enhances translation of Wnt/β-catenin target oncogenes Cancer Research. 70: 282-282. DOI: 10.1158/1538-7445.Am10-282  0.462
2010 Gunaratne P, Ghosh R, Mach C, Creighton CJ, Levine DA, Hayes DN, Wheeler D, Matzuk MM, Anderson ML, Gibbs RA. Abstract 2029: Identification of novel tumor suppressor microRNAs implicated in epithelial ovarian cancer from the 19q13.41 non-coding RNA cluster Cancer Research. 70: 2029-2029. DOI: 10.1158/1538-7445.Am10-2029  0.401
2010 Sun T, Meerbrey K, Kessler J, Botero M, Migliaccio I, Nguyen D, Pavlova N, Bernardi R, Schmitt E, Hilsenbeck S, Creighton C, Shaw C, Gibbs R, Wheeler D, Osborne C, et al. Abstract S6-10: Identification of a Novel Tumor Suppressor Network Reveals a Role for Proto-Oncogenic Receptor Tyrosine Kinases in Triple-Negative Breast Cancer Cancer Research. 70. DOI: 10.1158/0008-5472.Sabcs10-S6-10  0.458
2010 Arias PA, Creighton CJ, Yu Z, Gunaratne PH, Anderson ML, Matzuk MM, Hawkins SM. MicroRNAs in Endometrioid Ovarian Cancer Target the Ephrin Receptor Signaling Pathway. Biology of Reproduction. 83: 692-692. DOI: 10.1093/Biolreprod/83.S1.692  0.374
2010 Yu Z, Creighton C, Fountain MD, Nagaraja AK, Zhu H, Khan MF, Han DY, Olokpa E, Hawkins SM, Gunaratne P, Anderson ML, Matzuk MM. MiR-31 Is a Tumor Suppressor MicroRNA That Functions in Ovarian Cancer. Biology of Reproduction. 83: 35-35. DOI: 10.1093/Biolreprod/83.S1.35  0.368
2009 Gibbons DL, Lin W, Creighton C, Zhang S, Lozano G, Kurie J. Use of a murine model of NSCLC to evaluate the role of the microRNA-200 family in regulating EMT and metastasis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 11006. PMID 27964037 DOI: 10.1200/Jco.2009.27.15_Suppl.11006  0.397
2009 Chang CC, Zhou X, Taylor JJ, Huang WT, Ren X, Monzon F, Feng Y, Rao PH, Lu XY, Fabio F, Hilsenbeck S, Creighton CJ, Jaffe ES, Lau CC. Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma. Journal of Hematology & Oncology. 2: 47. PMID 19909553 DOI: 10.1186/1756-8722-2-47  0.302
2009 Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A, Kurie JM. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes & Development. 23: 2140-51. PMID 19759262 DOI: 10.1101/Gad.1820209  0.422
2009 Creighton CJ, Li X, Landis M, Dixon JM, Neumeister VM, Sjolund A, Rimm DL, Wong H, Rodriguez A, Herschkowitz JI, Fan C, Zhang X, He X, Pavlick A, Gutierrez MC, et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proceedings of the National Academy of Sciences of the United States of America. 106: 13820-5. PMID 19666588 DOI: 10.1073/Pnas.0905718106  0.411
2009 Dakhova O, Ozen M, Creighton CJ, Li R, Ayala G, Rowley D, Ittmann M. Global gene expression analysis of reactive stroma in prostate cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 3979-89. PMID 19509179 DOI: 10.1158/1078-0432.Ccr-08-1899  0.428
2009 Luo J, Emanuele MJ, Li D, Creighton CJ, Schlabach MR, Westbrook TF, Wong KK, Elledge SJ. A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene Cell. 137: 835-848. PMID 19490893 DOI: 10.1016/J.Cell.2009.05.006  0.369
2009 Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JM. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. Plos One. 4: e5401. PMID 19404390 DOI: 10.1371/Journal.Pone.0005401  0.368
2009 Choi K, Ahn YH, Gibbons DL, Tran HT, Creighton CJ, Girard L, Minna JD, Qin FX, Kurie JM. Distinct biological roles for the notch ligands Jagged-1 and Jagged-2. The Journal of Biological Chemistry. 284: 17766-74. PMID 19398556 DOI: 10.1074/Jbc.M109.003111  0.394
2009 Creighton CJ, Reid JG, Gunaratne PH. Expression profiling of microRNAs by deep sequencing. Briefings in Bioinformatics. 10: 490-7. PMID 19332473 DOI: 10.1093/Bib/Bbp019  0.321
2009 Castro P, Creighton CJ, Ozen M, Bcrel D, Mims MP, Ittmann M. Genomic profiling of prostate cancers from African American men 1 Neoplasia. 11: 305-312. PMID 19242612 DOI: 10.1593/Neo.81530  0.365
2009 Creighton CJ, Kent Osborne C, Van De Vijver MJ, Foekens JA, Klijn JG, Horlings HM, Nuyten D, Wang Y, Zhang Y, Chamness GC, Hilsenbeck SG, Lee AV, Schiff R. Molecular profiles of progesterone receptor loss in human breast tumors Breast Cancer Research and Treatment. 114: 287-299. PMID 18425577 DOI: 10.1007/S10549-008-0017-2  0.405
2009 Creighton C, Fu X, Hilsenbeck S, Osborne C, Hennessy B, Mills G, Lee A, Schiff R. Gene Expression Signatures of PI3K Signaling Are Associated with Low ER Levels and the Luminal B Subtype in Breast Cancer Cell Lines and Human Tumors, and in Patients Predicts Poor Outcome. Cancer Research. 69: 31-31. DOI: 10.1158/0008-5472.Sabcs-09-31  0.429
2009 Litzenburger B, Tsimelzon A, Hilsenbeck S, Creighton C, Carboni J, Gottardis M, Wicha M, Chang J, Lewis M, Lee A. High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer. Cancer Research. 69: 1132-1132. DOI: 10.1158/0008-5472.Sabcs-09-1132  0.439
2009 Casa A, Malik S, Lazard Z, Kuiatse I, Tsimelzon A, Creighton C, Hilsenbeck S, Lee A, Oesterreich S. Estrogen and IGF-I Independently Down-Regulate Critical Repressors of Breast Cancer Growth. Cancer Research. 69: 1126-1126. DOI: 10.1158/0008-5472.Sabcs-09-1126  0.435
2009 Yang Y, Ahn Y, Gibbons DL, Zang Y, Lin W, Thilaganthan N, Moreira DC, Creighton CJ, Goodall GJ, Kurie JM. Abstract A29: The Notch ligand Jagged2 promotes metastasis through a GATA3/miR‐200 regulatory loop Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-A29  0.416
2009 Ayala GE, Ding Y, Creighton C, Rowley DR. Neuronal Mimicry As A Resistance Phenotype In Cancer Cells The Journal of Urology. 181: 211-211. DOI: 10.1016/S0022-5347(09)60607-8  0.34
2008 Chang JC, Creighton C, Landis M, Lewis MT, Li X, Pavlick A, Rosen J, Perou CM, Rosen J. Gene signature of cancer stem cells in an intrinsic subgroup of breast cancers with mesenchymal properties. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 11009. PMID 27948335 DOI: 10.1200/Jco.2008.26.15_Suppl.11009  0.409
2008 Creighton CJ, Nagaraja AK, Hanash SM, Matzuk MM, Gunaratne PH. A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions. Rna (New York, N.Y.). 14: 2290-6. PMID 18812437 DOI: 10.1261/Rna.1188208  0.349
2008 Creighton CJ, Massarweh S, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, Shou J, Malorni L, Schiff R. Development of resistance to targeted therapies transforms the clinically associated molecular profile subtype of breast tumor xenografts. Cancer Research. 68: 7493-501. PMID 18794137 DOI: 10.1158/0008-5472.Can-08-1404  0.449
2008 Zhong L, Roybal J, Chaerkady R, Zhang W, Choi K, Alvarez CA, Tran H, Creighton CJ, Yan S, Strieter RM, Pandey A, Kurie JM. Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment Cancer Research. 68: 7237-7245. PMID 18757440 DOI: 10.1158/0008-5472.Can-08-1529  0.4
2008 Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, Osborne CK, Lee AV. Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 4078-85. PMID 18757322 DOI: 10.1200/Jco.2007.13.4429  0.451
2008 Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, Edwards DP, Lydon JP. Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology. 149: 6236-50. PMID 18687774 DOI: 10.1210/En.2008-0768  0.373
2008 Gu P, Reid JG, Gao X, Shaw CA, Creighton C, Tran PL, Zhou X, Drabek RB, Steffen DL, Hoang DM, Weiss MK, Naghavi AO, El-daye J, Khan MF, Legge GB, et al. Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. Plos One. 3: e2548. PMID 18648548 DOI: 10.1371/Journal.Pone.0002548  0.305
2008 Creighton CJ. Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors Plos One. 3. PMID 18350153 DOI: 10.1371/Journal.Pone.0001816  0.424
2008 Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Moghaddam S, Evans CM, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton CJ, Demayo FJ, et al. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Research. 68: 1119-27. PMID 18281487 DOI: 10.1158/0008-5472.Can-07-3117  0.315
2008 Massarweh S, Osborne CK, Creighton CJ, Qin L, Tsimelzon A, Huang S, Weiss H, Rimawi M, Schiff R. Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function. Cancer Research. 68: 826-33. PMID 18245484 DOI: 10.1158/0008-5472.Can-07-2707  0.389
2008 Ozen M, Creighton CJ, Ozdemir M, Ittmann M. Widespread deregulation of microRNA expression in human prostate cancer Oncogene. 27: 1788-1793. PMID 17891175 DOI: 10.1038/Sj.Onc.1210809  0.377
2008 Nagaraja AK, Creighton CJ, Reid JG, Gunaratne PH, Ma L, Anderson ML, Matzuk MM. MicroRNAs in Human Ovarian Cancer. Biology of Reproduction. 78: 200-200. DOI: 10.1093/Biolreprod/78.S1.200A  0.369
2007 Choi K, Creighton CJ, Stivers D, Fujimoto N, Kurie JM. Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations Plos One. 2. PMID 18030354 DOI: 10.1371/Journal.Pone.0001226  0.357
2007 Yu J, Cao Q, Mehra R, Laxman B, Yu J, Tomlins SA, Creighton CJ, Dhanasekaran SM, Shen R, Chen G, Morris DS, Marquez VE, Shah RB, Ghosh D, Varambally S, et al. Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell. 12: 419-31. PMID 17996646 DOI: 10.1016/J.Ccr.2007.10.016  0.422
2007 Creighton CJ. A gene transcription signature associated with hormone independence in a subset of both breast and prostate cancers Bmc Genomics. 8. PMID 17598908 DOI: 10.1186/1471-2164-8-199  0.443
2007 Creighton CJ. A gene transcription signature of the Akt/mTOR pathway in clinical breast tumors Oncogene. 26: 4648-4655. PMID 17213801 DOI: 10.1038/Sj.Onc.1210245  0.451
2007 Rae JM, Creighton CJ, Meck JM, Haddad BR, Johnson MD. MDA-MB-435 cells are derived from M14 melanoma cells--a loss for breast cancer, but a boon for melanoma research. Breast Cancer Research and Treatment. 104: 13-9. PMID 17004106 DOI: 10.1007/S10549-006-9392-8  0.379
2007 Chang JC, Li X, Wong H, Creighton C, Hilsenbeck SG, Osborne CK, Rosen JM, Lewis MT. Therapeutic resistance and tumor-initiation: Molecular pathways involved in breast cancer stem cell self-renewal Journal of Clinical Oncology. 25: 528-528. DOI: 10.1200/Jco.2007.25.18_Suppl.528  0.396
2007 Makris A, Creighton C, Osborne KC, Hilsenbeck S, Harrison MK, Ostler PJ, Spears C, Brown P, Elledge R, Chang JC. Predictive gene expression patterns of response to adriamycin and cyclophosphamide (AC) in human breast cancers Journal of Clinical Oncology. 25: 527-527. DOI: 10.1200/Jco.2007.25.18_Suppl.527  0.38
2007 Tham Y, Creighton C, Gutierrez C, Osborne CK, Brown P, Chang JC. A gene expression signature of eventual brain metastases in patients with breast cancer Journal of Clinical Oncology. 25: 1019-1019. DOI: 10.1200/Jco.2007.25.18_Suppl.1019  0.389
2006 Creighton CJ, Rae JM. When will tumor gene expression profiling be incorporated into clinical breast cancer decision making? Breast Cancer Research : Bcr. 8: 302. PMID 16834787 DOI: 10.1186/Bcr1519  0.442
2006 Haas CS, Creighton CJ, Pi X, Maine I, Koch AE, Haines GK, Ling S, Chinnaiyan AM, Holoshitz J. Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins Arthritis and Rheumatism. 54: 2047-2060. PMID 16804865 DOI: 10.1002/Art.21953  0.308
2006 Creighton CJ, Cordero KE, Larios JM, Miller RS, Johnson MD, Chinnaiyan AM, Lippman ME, Rae JM. Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biology. 7: R28. PMID 16606439 DOI: 10.1186/Gb-2006-7-4-R28  0.452
2006 Creighton CJ, Hilger AM, Murthy S, Rae JM, Chinnaiyan AM, El-Ashry D. Activation of mitogen-activated protein kinase in estrogen receptor alpha-positive breast cancer cells in vitro induces an in vivo molecular phenotype of estrogen receptor alpha-negative human breast tumors. Cancer Research. 66: 3903-11. PMID 16585219 DOI: 10.1158/0008-5472.Can-05-4363  0.472
2006 Creighton C, Rae J, Chinnaiyan A, Lippman M. Improved prediction of disease-free survival in tamoxifen-treated patients using an expression signature of estrogen-regulated genes as compared to progesterone receptor Journal of Clinical Oncology. 24: 535-535. DOI: 10.1200/Jco.2006.24.18_Suppl.535  0.412
2005 Creighton CJ, Bromberg-White JL, Misek DE, Monsma DJ, Brichory F, Kuick R, Giordano TJ, Gao W, Omenn GS, Webb CP, Hanash SM. Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation. Molecular Cancer Research : McR. 3: 119-29. PMID 15798092 DOI: 10.1158/1541-7786.Mcr-04-0189  0.466
2005 Dhanasekaran SM, Dash A, Yu J, Maine IP, Laxman B, Tomlins SA, Creighton CJ, Menon A, Rubin MA, Chinnaiyan AM. Molecular profiling of human prostate tissues: insights into gene expression patterns of prostate development during puberty The Faseb Journal. 19: 243-245. PMID 15548588 DOI: 10.1096/Fj.04-2415Fje  0.307
2003 Hanash S, Creighton C. Making sense of microarray data to classify cancer Pharmacogenomics Journal. 3: 308-311. PMID 14597962 DOI: 10.1038/Sj.Tpj.6500209  0.409
2003 Creighton C, Kuick R, Misek DE, Rickman DS, Brichory FM, Rouillard JM, Omenn GS, Hanash S. Profiling of pathway-specific changes in gene expression following growth of human cancer cell lines transplanted into mice. Genome Biology. 4: R46. PMID 12844362 DOI: 10.1186/Gb-2003-4-7-R46  0.476
2003 Creighton C, Hanash S, Beer D. Gene expression patterns define pathways correlated with loss of differentiation in lung adenocarcinomas. Febs Letters. 540: 167-170. PMID 12681502 DOI: 10.1016/S0014-5793(03)00259-X  0.387
2003 Creighton C, Hanash S. Mining gene expression databases for association rules Bioinformatics. 19: 79-86. PMID 12499296 DOI: 10.1093/Bioinformatics/19.1.79  0.314
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