Year |
Citation |
Score |
2015 |
Chang JW, Zuhl AM, Speers AE, Niessen S, Brown SJ, Mulvihill MM, Fan YC, Spicer TP, Southern M, Scampavia L, Fernandez-Vega V, Dix MM, Cameron MD, Hodder PS, Rosen H, et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival. Acs Chemical Biology. 10: 925-32. PMID 25602368 DOI: 10.1021/Cb500893Q |
0.734 |
|
2015 |
Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/Cb500746Z |
0.553 |
|
2013 |
Ward J, Spath SN, Pabst B, Carpino PA, Ruggeri RB, Xing G, Speers AE, Cravatt BF, Ahn K. Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling. Biochemistry. 52: 9187-201. PMID 24320749 DOI: 10.1021/Bi401354D |
0.643 |
|
2013 |
Hsu KL, Tsuboi K, Chang JW, Whitby LR, Speers AE, Pugh H, Cravatt BF. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). Journal of Medicinal Chemistry. 56: 8270-9. PMID 24152295 DOI: 10.1021/Jm400899C |
0.764 |
|
2013 |
Hsu KL, Tsuboi K, Whitby LR, Speers AE, Pugh H, Inloes J, Cravatt BF. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis. Journal of Medicinal Chemistry. 56: 8257-69. PMID 24152245 DOI: 10.1021/Jm400898X |
0.776 |
|
2013 |
Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2). Bioorganic & Medicinal Chemistry Letters. 23: 839-43. PMID 23260346 DOI: 10.1016/J.Bmcl.2012.11.061 |
0.712 |
|
2012 |
Liu X, Dix M, Speers AE, Bachovchin DA, Zuhl AM, Cravatt BF, Kodadek TJ. Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9. Chembiochem : a European Journal of Chemical Biology. 13: 2082-93. PMID 22907802 DOI: 10.1002/Cbic.201200445 |
0.763 |
|
2012 |
Saario SM, McKinney MK, Speers AE, Wang C, Cravatt BF. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase(). Chemical Science (Royal Society of Chemistry : 2010). 3: 77-83. PMID 22737400 DOI: 10.1039/C1Sc00336D |
0.751 |
|
2012 |
Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes. Journal of the American Chemical Society. 134: 10345-8. PMID 22690931 DOI: 10.1021/Ja303400U |
0.789 |
|
2011 |
Rowland MM, Bostic HE, Gong D, Speers AE, Lucas N, Cho W, Cravatt BF, Best MD. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners. Biochemistry. 50: 11143-61. PMID 22074223 DOI: 10.1021/Bi201636S |
0.557 |
|
2011 |
Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. Journal of the American Chemical Society. 133: 16605-16. PMID 21899313 DOI: 10.1021/Ja2066972 |
0.621 |
|
2011 |
Lone AM, Bachovchin DA, Westwood DB, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF, Saghatelian A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors. Journal of the American Chemical Society. 133: 11665-74. PMID 21692504 DOI: 10.1021/Ja2036095 |
0.746 |
|
2011 |
Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. Journal of Medicinal Chemistry. 54: 5229-36. PMID 21639134 DOI: 10.1021/Jm200502U |
0.759 |
|
2011 |
Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 108: 6811-6. PMID 21398589 DOI: 10.1073/Pnas.1015248108 |
0.75 |
|
2010 |
Speers AE, Cravatt BF. Ligands in crystal structures that aid in functional characterization. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1306-8. PMID 20944226 DOI: 10.1107/S1744309110035748 |
0.473 |
|
2009 |
Speers AE, Cravatt BF. Activity-Based Protein Profiling (ABPP) and Click Chemistry (CC)-ABPP by MudPIT Mass Spectrometry. Current Protocols in Chemical Biology. 1: 29-41. PMID 21701697 DOI: 10.1002/9780470559277.Ch090138 |
0.594 |
|
2008 |
Blackler AR, Speers AE, Wu CC. Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins. Proteomics. 8: 3956-64. PMID 18780350 DOI: 10.1002/Pmic.200800210 |
0.353 |
|
2008 |
Blackler AR, Speers AE, Ladinsky MS, Wu CC. A shotgun proteomic method for the identification of membrane-embedded proteins and peptides. Journal of Proteome Research. 7: 3028-34. PMID 18537282 DOI: 10.1021/Pr700795F |
0.31 |
|
2008 |
Speers AE, Wu CC. Chapter 10 Bottom-Up Mass Spectrometry Analysis of Integral Membrane Protein Structure and Topology Comprehensive Analytical Chemistry. 52: 213-243. DOI: 10.1016/S0166-526X(08)00210-9 |
0.36 |
|
2007 |
Weerapana E, Speers AE, Cravatt BF. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes. Nature Protocols. 2: 1414-25. PMID 17545978 DOI: 10.1038/Nprot.2007.194 |
0.714 |
|
2005 |
Speers AE, Cravatt BF. A tandem orthogonal proteolysis strategy for high-content chemical proteomics. Journal of the American Chemical Society. 127: 10018-9. PMID 16011363 DOI: 10.1021/Ja0532842 |
0.623 |
|
2004 |
Speers AE, Cravatt BF. Profiling enzyme activities in vivo using click chemistry methods. Chemistry & Biology. 11: 535-46. PMID 15123248 DOI: 10.1016/J.Chembiol.2004.03.012 |
0.623 |
|
2004 |
Speers AE, Cravatt BF. Chemical strategies for activity-based proteomics. Chembiochem : a European Journal of Chemical Biology. 5: 41-7. PMID 14695510 DOI: 10.1002/Cbic.200300721 |
0.618 |
|
2003 |
Speers AE, Adam GC, Cravatt BF. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. Journal of the American Chemical Society. 125: 4686-7. PMID 12696868 DOI: 10.1021/Ja034490H |
0.758 |
|
Show low-probability matches. |