Matthew L. Hillwig, Ph.D. - Publications

Affiliations: 
2008 Genetics, Development and Cell Biology Iowa State University, Ames, IA, United States 

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hillwig ML, Zhu Q, Ittiamornkul K, Liu X. Discovery of a Promiscuous Non-Heme Iron Halogenase in Ambiguine Alkaloid Biogenesis: Implication for an Evolvable Enzyme Family for Late-Stage Halogenation of Aliphatic Carbons in Small Molecules. Angewandte Chemie (International Ed. in English). PMID 27027281 DOI: 10.1002/anie.201601447  0.4
2016 Mafu S, Jia M, Zi J, Morrone D, Wu Y, Xu M, Hillwig ML, Peters RJ. Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884192 DOI: 10.1073/pnas.1512096113  0.4
2016 Zhu Q, Hillwig ML, Doi Y, Liu X. Aliphatic Halogenase Enables Late-Stage C-H Functionalization: Selective Synthesis of Brominated Fischerindole Alkaloid with Enhanced Antibacterial Activity. Chembiochem : a European Journal of Chemical Biology. PMID 26749394 DOI: 10.1002/cbic.201500674  0.4
2016 Liu X, Hillwig ML, Koharudin LM, Gronenborn AM. Unified biogenesis of ambiguine, fischerindole, hapalindole and welwitindolinone: identification of a monogeranylated indolenine as a cryptic common biosynthetic intermediate by an unusual magnesium-dependent aromatic prenyltransferase. Chemical Communications (Cambridge, England). PMID 26740122 DOI: 10.1039/c5cc10060g  0.4
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... Hillwig ML, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/nchembio.1890  0.4
2015 Mafu S, Potter KC, Hillwig ML, Schulte S, Criswell J, Peters RJ. Efficient heterocyclisation by (di)terpene synthases. Chemical Communications (Cambridge, England). 51: 13485-7. PMID 26214384 DOI: 10.1039/c5cc05754j  0.4
2015 Ittiamornkul K, Zhu Q, Gkotsi DS, Smith DRM, Hillwig ML, Nightingale N, Goss RJM, Liu X. Promiscuous indolyl vinyl isonitrile synthases in the biogenesis and diversification of hapalindole-type alkaloids Chemical Science. 6: 6836-6840. DOI: 10.1039/c5sc02919h  0.4
2014 Hillwig ML, Liu X. A new family of iron-dependent halogenases acts on freestanding substrates. Nature Chemical Biology. 10: 921-3. PMID 25218740 DOI: 10.1038/nchembio.1625  0.4
2014 Xu M, Hillwig ML, Lane AL, Tiernan MS, Moore BS, Peters RJ. Characterization of an orphan diterpenoid biosynthetic operon from Salinispora arenicola. Journal of Natural Products. 77: 2144-7. PMID 25203741 DOI: 10.1021/np500422d  0.4
2014 Hillwig ML, Fuhrman HA, Ittiamornkul K, Sevco TJ, Kwak DH, Liu X. Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii. Chembiochem : a European Journal of Chemical Biology. 15: 665-9. PMID 24677572 DOI: 10.1002/cbic.201300794  0.4
2014 Gao W, Sun HX, Xiao H, Cui G, Hillwig ML, Jackson A, Wang X, Shen Y, Zhao N, Zhang L, Wang XJ, Peters RJ, Huang L. Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza. Bmc Genomics. 15: 73. PMID 24467826 DOI: 10.1186/1471-2164-15-73  0.4
2014 Hillwig ML, Zhu Q, Liu X. Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua. Acs Chemical Biology. 9: 372-7. PMID 24180436 DOI: 10.1021/cb400681n  0.4
2013 Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang Y, Zhang X, Liu W, Peters RJ, Chen X, Zhao ZK, Huang L. CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. Proceedings of the National Academy of Sciences of the United States of America. 110: 12108-13. PMID 23812755 DOI: 10.1073/pnas.1218061110  0.4
2013 Wu Y, Wang Q, Hillwig ML, Peters RJ. Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis. The Biochemical Journal. 454: 209-16. PMID 23795884 DOI: 10.1042/BJ20130574  0.4
2012 Wang Q, Hillwig ML, Wu Y, Peters RJ. CYP701A8: a rice ent-kaurene oxidase paralog diverted to more specialized diterpenoid metabolism. Plant Physiology. 158: 1418-25. PMID 22247270 DOI: 10.1104/pp.111.187518  0.4
2012 Wang Q, Hillwig ML, Okada K, Yamazaki K, Wu Y, Swaminathan S, Yamane H, Peters RJ. Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster. The Journal of Biological Chemistry. 287: 6159-68. PMID 22215681 DOI: 10.1074/jbc.M111.305599  0.4
2011 Hillwig ML, Xu M, Toyomasu T, Tiernan MS, Wei G, Cui G, Huang L, Peters RJ. Domain loss has independently occurred multiple times in plant terpene synthase evolution. The Plant Journal : For Cell and Molecular Biology. 68: 1051-60. PMID 21999670 DOI: 10.1111/j.1365-313X.2011.04756.x  0.4
2011 Wu Y, Hillwig ML, Wang Q, Peters RJ. Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7. Febs Letters. 585: 3446-51. PMID 21985968 DOI: 10.1016/j.febslet.2011.09.038  0.4
2011 Mafu S, Hillwig ML, Peters RJ. A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii. Chembiochem : a European Journal of Chemical Biology. 12: 1984-7. PMID 21751328 DOI: 10.1002/cbic.201100336  0.4
2011 Morrone D, Hillwig ML, Mead ME, Lowry L, Fulton DB, Peters RJ. Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals. The Biochemical Journal. 435: 589-95. PMID 21323642 DOI: 10.1042/BJ20101429  0.4
2011 Wang Q, Hillwig ML, Peters RJ. CYP99A3: functional identification of a diterpene oxidase from the momilactone biosynthetic gene cluster in rice. The Plant Journal : For Cell and Molecular Biology. 65: 87-95. PMID 21175892 DOI: 10.1111/j.1365-313X.2010.04408.x  0.4
2011 Hillwig ML, Mann FM, Peters RJ. Diterpenoid biopolymers: new directions for renewable materials engineering. Biopolymers. 95: 71-6. PMID 20857504 DOI: 10.1002/bip.21538  0.4
2010 Maugel N, Mann FM, Hillwig ML, Peters RJ, Snider BB. Synthesis of (+/-)-nosyberkol (isotuberculosinol, revised structure of edaxadiene) and (+/-)-tuberculosinol. Organic Letters. 12: 2626-9. PMID 20462237 DOI: 10.1021/ol100832h  0.4
2009 Birt DF, Widrlechner MP, Hammer KD, Hillwig ML, Wei J, Kraus GA, Murphy PA, McCoy J, Wurtele ES, Neighbors JD, Wiemer DF, Maury WJ, Price JP. Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents. Pharmaceutical Biology. 47: 774-782. PMID 19907671 DOI: 10.1080/13880200902988645  0.4
2009 Gao W, Hillwig ML, Huang L, Cui G, Wang X, Kong J, Yang B, Peters RJ. A functional genomics approach to tanshinone biosynthesis provides stereochemical insights. Organic Letters. 11: 5170-3. PMID 19905026 DOI: 10.1021/ol902051v  0.4
2008 Hammer KD, Hillwig ML, Neighbors JD, Sim YJ, Kohut ML, Wiemer DF, Wurtele ES, Birt DF. Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. Phytochemistry. 69: 2354-62. PMID 18707743 DOI: 10.1016/j.phytochem.2008.06.010  0.4
2008 Hillwig ML, Hammer KD, Birt DF, Wurtele ES. Characterizing the metabolic fingerprint and anti-inflammatory activity of Hypericum gentianoides. Journal of Agricultural and Food Chemistry. 56: 4359-66. PMID 18512936 DOI: 10.1021/jf800411v  0.4
2007 Hammer KD, Hillwig ML, Solco AK, Dixon PM, Delate K, Murphy PA, Wurtele ES, Birt DF. Inhibition of prostaglandin E(2) production by anti-inflammatory hypericum perforatum extracts and constituents in RAW264.7 Mouse Macrophage Cells. Journal of Agricultural and Food Chemistry. 55: 7323-31. PMID 17696442 DOI: 10.1021/jf0710074  0.4
2004 Xu M, Hillwig ML, Prisic S, Coates RM, Peters RJ. Functional identification of rice syn-copalyl diphosphate synthase and its role in initiating biosynthesis of diterpenoid phytoalexin/allelopathic natural products. The Plant Journal : For Cell and Molecular Biology. 39: 309-18. PMID 15255861 DOI: 10.1111/j.1365-313X.2004.02137.x  0.4
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