Joseph L. Greenstein, Ph.D. - Publications

Affiliations: 
2002 Johns Hopkins University, Baltimore, MD 

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jin Q, Greenstein JL, Winslow RL. Estimating the probability of early afterdepolarizations and predicting arrhythmic risk associated with long QT syndrome type 1 mutations. Biophysical Journal. 122: 4042-4056. PMID 37705243 DOI: 10.1016/j.bpj.2023.09.001  0.527
2023 Bose SN, Defante A, Greenstein JL, Haddad GG, Ryu J, Winslow RL. A data-driven model for early prediction of need for invasive mechanical ventilation in pediatric intensive care unit patients. Plos One. 18: e0289763. PMID 37540703 DOI: 10.1371/journal.pone.0289763  0.469
2023 Tan Y, Young M, Girish A, Hu B, Kurian Z, Greenstein JL, Kim H, Winslow RL, Fackler J, Bergmann J. Predicting respiratory decompensation in mechanically ventilated adult ICU patients. Frontiers in Physiology. 14: 1125991. PMID 37123253 DOI: 10.3389/fphys.2023.1125991  0.486
2022 Gong KD, Lu R, Bergamaschi TS, Sanyal A, Guo J, Kim HB, Nguyen HT, Greenstein JL, Winslow RL, Stevens RD. Predicting Intensive Care Delirium with Machine Learning: Model Development and External Validation. Anesthesiology. PMID 36538354 DOI: 10.1097/ALN.0000000000004478  0.463
2022 Wagle N, Morkos J, Liu J, Reith H, Greenstein J, Gong K, Gangan I, Pakhomov D, Hira S, Komogortsev OV, Newman-Toker DE, Winslow R, Zee DS, Otero-Millan J, Green KE. aEYE: A deep learning system for video nystagmus detection. Frontiers in Neurology. 13: 963968. PMID 36034311 DOI: 10.3389/fneur.2022.963968  0.435
2021 Kim HB, Nguyen HT, Jin Q, Tamby S, Gelaf Romer T, Sung E, Liu R, Greenstein JL, Suarez JI, Storm C, Winslow RL, Stevens RD. Computational Signatures for Post-Cardiac Arrest Trajectory Prediction: Importance of Early Physiological Time Series. Anaesthesia, Critical Care & Pain Medicine. 101015. PMID 34968747 DOI: 10.1016/j.accpm.2021.101015  0.566
2021 Annapragada AV, Greenstein JL, Bose SN, Winters BD, Sarma SV, Winslow RL. SWIFT: A deep learning approach to prediction of hypoxemic events in critically-Ill patients using SpO2 waveform prediction. Plos Computational Biology. 17: e1009712. PMID 34932550 DOI: 10.1371/journal.pcbi.1009712  0.484
2021 Krachman JA, Patricoski JA, Le CT, Park J, Zhang R, Gong KD, Gangan I, Winslow RL, Greenstein JL, Fackler J, Sochet AA, Bergmann JP. Predicting Flow Rate Escalation for Pediatric Patients on High Flow Nasal Cannula Using Machine Learning. Frontiers in Pediatrics. 9: 734753. PMID 34820341 DOI: 10.3389/fped.2021.734753  0.468
2021 Jin Q, Greenstein JL, Winslow RL. Estimating ectopic beat probability with simplified statistical models that account for experimental uncertainty. Plos Computational Biology. 17: e1009536. PMID 34665814 DOI: 10.1371/journal.pcbi.1009536  0.645
2021 Bose SN, Greenstein JL, Fackler JC, Sarma SV, Winslow RL, Bembea MM. Early Prediction of Multiple Organ Dysfunction in the Pediatric Intensive Care Unit. Frontiers in Pediatrics. 9: 711104. PMID 34485201 DOI: 10.3389/fped.2021.711104  0.475
2021 Liu R, Greenstein JL, Fackler JC, Bergmann J, Bembea MM, Winslow RL. Prediction of Impending Septic Shock in Children With Sepsis. Critical Care Explorations. 3: e0442. PMID 34151278 DOI: 10.1097/CCE.0000000000000442  0.455
2021 Annapragada AV, Greenstein JL, Bose SN, Winters BD, Sarma SV, Winslow RL. SWIFT: A Deep Learning Approach to Prediction of Hypoxemic Events in Critically-Ill Patients Using SpO Waveform Prediction. Medrxiv : the Preprint Server For Health Sciences. PMID 33688661 DOI: 10.1101/2021.02.25.21252234  0.482
2020 Liu R, Greenstein JL, Fackler JC, Bembea MM, Winslow RL. Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received. Elife. 9. PMID 32959779 DOI: 10.7554/Elife.58142  0.507
2020 Jin Q, Greenstein JL, Winslow RL. Simplified Models Predict Cellular Arrhythmia Probabilities and Reveal the Impact of Experimental Parameter Uncertainty on the Predicted Distribution of Arrhythmic Events Biophysical Journal. 118: 409a. DOI: 10.1016/J.Bpj.2019.11.2316  0.548
2019 Liu R, Greenstein JL, Sarma SV, Winslow RL. Natural Language Processing of Clinical Notes for Improved Early Prediction of Septic Shock in the ICU. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2019: 6103-6108. PMID 31947237 DOI: 10.1109/EMBC.2019.8857819  0.46
2019 Liu R, Greenstein JL, Granite SJ, Fackler JC, Bembea MM, Sarma SV, Winslow RL. Data-driven discovery of a novel sepsis pre-shock state predicts impending septic shock in the ICU. Scientific Reports. 9: 6145. PMID 30992534 DOI: 10.1038/S41598-019-42637-5  0.521
2019 Chu L, Greenstein JL, Winslow RL. Na microdomains and sparks: Role in cardiac excitation-contraction coupling and arrhythmias in ankyrin-B deficiency. Journal of Molecular and Cellular Cardiology. PMID 30731085 DOI: 10.1016/J.Yjmcc.2019.02.001  0.701
2019 Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL. Probing L-Type Channel Calcium-Dependent Inactivation -- a Bilobal Model of Calmodulation Biophysical Journal. 116: 111a. DOI: 10.1016/J.Bpj.2018.11.631  0.582
2018 Limpitikul WB, Greenstein JL, Yue DT, Dick IE, Winslow RL. A bilobal model of Ca-dependent inactivation to probe the physiology of L-type Ca channels. The Journal of General Physiology. PMID 30470716 DOI: 10.1085/Jgp.201812115  0.724
2017 Walker MA, Gurev V, Rice JJ, Greenstein JL, Winslow RL. Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue. Plos Computational Biology. 13: e1005783. PMID 29145393 DOI: 10.1371/Journal.Pcbi.1005783  0.714
2017 Zhao CY, Greenstein JL, Winslow RL. Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type Calcium Channel regulation. Journal of Molecular and Cellular Cardiology. PMID 28365422 DOI: 10.1016/J.Yjmcc.2017.01.013  0.638
2016 Chu L, Greenstein JL, Winslow RL. Modeling Na(+)-Ca(2+) exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling. Journal of Molecular and Cellular Cardiology. PMID 27377851 DOI: 10.1016/J.Yjmcc.2016.06.068  0.7
2016 Walker MA, Madduri R, Rodriguez A, Greenstein JL, Winslow RL. Models and Simulations as a Service: Exploring the Use of Galaxy for Delivering Computational Models. Biophysical Journal. 110: 1038-43. PMID 26958881 DOI: 10.1016/J.Bpj.2015.12.041  0.579
2016 Zhao CY, Greenstein JL, Winslow RL. Roles of phosphodiesterases in the regulation of the cardiac cyclic nucleotide cross-talk signaling network. Journal of Molecular and Cellular Cardiology. PMID 26773602 DOI: 10.1016/J.Yjmcc.2016.01.004  0.589
2016 Chu L, Greenstein JL, Winslow RL. Modeling the Role of NCX in the Regulation of Cardiomyocyte Microdomain Ca2+ Dynamics Biophysical Journal. 110: 99a. DOI: 10.1016/J.Bpj.2015.11.592  0.705
2016 Zhao CY, Greenstein JL, Winslow RL. Regulation of the Cardiac L-Type Calcium Channel by the Cyclic Nucleotide Cross-Talk Signaling Network Biophysical Journal. 110: 359a. DOI: 10.1016/J.Bpj.2015.11.1937  0.647
2015 Winslow RL, Walker MA, Greenstein JL. Modeling calcium regulation of contraction, energetics, signaling, and transcription in the cardiac myocyte. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26562359 DOI: 10.1002/Wsbm.1322  0.695
2015 Walker MA, Kohl T, Lehnart SE, Greenstein JL, Lederer WJ, Winslow RL. On the Adjacency Matrix of RyR2 Cluster Structures. Plos Computational Biology. 11: e1004521. PMID 26545234 DOI: 10.1371/Journal.Pcbi.1004521  0.668
2015 Zhao CY, Greenstein JL, Winslow RL. Interaction between phosphodiesterases in the regulation of the cardiac β-adrenergic pathway. Journal of Molecular and Cellular Cardiology. 88: 29-38. PMID 26388264 DOI: 10.1016/J.Yjmcc.2015.09.011  0.619
2015 Foteinou PT, Greenstein JL, Winslow RL. Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart. Biophysical Journal. 109: 838-49. PMID 26287635 DOI: 10.1016/J.Bpj.2015.06.064  0.714
2015 Greenstein JL, Mehta T, Winslow RL. Effect of Hypertrophic Calcium Signals and Altered Excitation-Contraction Coupling on the Calcineurin-NFAT Pathway Biophysical Journal. 108: 420a. DOI: 10.1016/J.Bpj.2014.11.2298  0.712
2015 Chu L, Greenstein JL, Williams GS, Boyman L, Legenzov EA, Hagen BM, Lederer W, Winslow RL. Dynamics of Ca2+-Dependent Regulation of the Cardiac Na+/Ca2+ Exchanger Biophysical Journal. 108: 265a. DOI: 10.1016/J.Bpj.2014.11.1462  0.684
2015 Zhao CY, Greenstein JL, Winslow RL. Regulation of the Cardiac β-Adrenergic Pathway via Camp-Cgmp Competition Biophysical Journal. 108: 260a. DOI: 10.1016/J.Bpj.2014.11.1438  0.61
2015 Zhao CY, Greenstein JL, Winslow RL. Roles of Phosphodiesterases in Cyclic Nucleotide Cross-Talk in Cardiac Myocytes Biophysical Journal. 108: 260a. DOI: 10.1016/J.Bpj.2014.11.1437  0.595
2014 Walker MA, Williams GS, Kohl T, Lehnart SE, Jafri MS, Greenstein JL, Lederer WJ, Winslow RL. Superresolution modeling of calcium release in the heart. Biophysical Journal. 107: 3018-29. PMID 25517166 DOI: 10.1016/J.Bpj.2014.11.003  0.697
2014 Greenstein JL, Foteinou PT, Hashambhoy-Ramsay YL, Winslow RL. Modeling CaMKII-mediated regulation of L-type Ca(2+) channels and ryanodine receptors in the heart. Frontiers in Pharmacology. 5: 60. PMID 24772082 DOI: 10.3389/Fphar.2014.00060  0.724
2014 Walker MA, Williams GS, Kohl T, Jafri S, Lehnart SE, Greenstein JL, Lederer W, Winslow RL. Super-Resolution Modeling of Calcium Release in Heart Biophysical Journal. 106: 318a. DOI: 10.1016/j.bpj.2013.11.1839  0.543
2013 Gauthier LD, Greenstein JL, O'Rourke B, Winslow RL. An integrated mitochondrial ROS production and scavenging model: implications for heart failure. Biophysical Journal. 105: 2832-42. PMID 24359755 DOI: 10.1016/J.Bpj.2013.11.007  0.807
2013 Gauthier LD, Greenstein JL, Cortassa S, O'Rourke B, Winslow RL. A computational model of reactive oxygen species and redox balance in cardiac mitochondria. Biophysical Journal. 105: 1045-56. PMID 23972856 DOI: 10.1016/J.Bpj.2013.07.006  0.763
2013 Winslow RL, Greenstein JL. Extinguishing the sparks. Biophysical Journal. 104: 2115-7. PMID 23708349 DOI: 10.1016/J.Bpj.2013.04.010  0.669
2013 Aiba T, Barth AS, Hesketh GG, Hashambhoy YL, Chakir K, Tunin RS, Greenstein JL, Winslow RL, Kass DA, Tomaselli GF. Cardiac resynchronization therapy improves altered Na channel gating in canine model of dyssynchronous heart failure. Circulation. Arrhythmia and Electrophysiology. 6: 546-54. PMID 23650309 DOI: 10.1161/Circep.113.000400  0.808
2013 Gauthier LD, Cortassa S, Greenstein JL, Winslow RL. Mechanistic Electron Transport Chain Model Explains ROS Production in Different Respiratory Modes Biophysical Journal. 104: 304a-305a. DOI: 10.1016/J.Bpj.2012.11.1694  0.762
2012 Gauthier LD, Greenstein JL, Winslow RL. Toward an integrative computational model of the Guinea pig cardiac myocyte. Frontiers in Physiology. 3: 244. PMID 22783206 DOI: 10.3389/Fphys.2012.00244  0.833
2012 Gauthier LD, Greenstein JL, Winslow RL. Local Control Model Illustrates How Action Potential Morphology Affects Ca2+ Release Biophysical Journal. 102: 553a. DOI: 10.1016/J.Bpj.2011.11.3016  0.819
2011 Hashambhoy YL, Winslow RL, Greenstein JL. CaMKII-dependent activation of late INa contributes to cellular arrhythmia in a model of the cardiac myocyte. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 4665-8. PMID 22255378 DOI: 10.1109/IEMBS.2011.6091155  0.826
2011 Winslow RL, Greenstein JL. Cardiac myocytes and local signaling in nano-domains. Progress in Biophysics and Molecular Biology. 107: 48-59. PMID 21718716 DOI: 10.1016/J.Pbiomolbio.2011.06.005  0.661
2011 Greenstein JL, Winslow RL. Integrative systems models of cardiac excitation-contraction coupling. Circulation Research. 108: 70-84. PMID 21212390 DOI: 10.1161/Circresaha.110.223578  0.703
2011 Winslow RL, Cortassa S, O'Rourke B, Hashambhoy YL, Rice JJ, Greenstein JL. Integrative modeling of the cardiac ventricular myocyte. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 392-413. PMID 20865780 DOI: 10.1002/Wsbm.122  0.817
2011 Jafri MS, Lederer WJ, Williams GS, Greenstein JL, Winslow RL. Modeling the Mechanisms of Calcium-Mediated Cardiac Arrhythmias Biophysical Journal. 100: 556a-557a. DOI: 10.1016/J.Bpj.2010.12.3236  0.603
2011 Gauthier LD, Greenstein JL, Winslow RL. The Role of Reactive Oxygen Species in Contractile Dysfunction Following Ischemia/Reperfusion Biophysical Journal. 100: 292a. DOI: 10.1016/J.Bpj.2010.12.1796  0.812
2010 Hashambhoy YL, Greenstein JL, Winslow RL. Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model. Journal of Molecular and Cellular Cardiology. 49: 617-24. PMID 20655925 DOI: 10.1016/J.Yjmcc.2010.07.011  0.834
2010 Doyle LA, Greenstein JL, Winslow RL. Multi-Scale, Integrative Model Development using High-Performance Computer Architectures Biophysical Journal. 98: 574a. DOI: 10.1016/J.Bpj.2009.12.3120  0.643
2010 Hashambhoy YL, Winslow RL, Greenstein JL. CamkII Phosphorylation of RyRs: a Mechanistic Mathematical Model Biophysical Journal. 98: 548a-549a. DOI: 10.1016/J.Bpj.2009.12.2973  0.83
2009 Maleckar MM, Greenstein JL, Giles WR, Trayanova NA. Electrotonic coupling between human atrial myocytes and fibroblasts alters myocyte excitability and repolarization. Biophysical Journal. 97: 2179-90. PMID 19843450 DOI: 10.1016/J.Bpj.2009.07.054  0.37
2009 Maleckar MM, Greenstein JL, Giles WR, Trayanova NA. K+ current changes account for the rate dependence of the action potential in the human atrial myocyte. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1398-410. PMID 19633207 DOI: 10.1152/Ajpheart.00411.2009  0.36
2009 Hashambhoy YL, Winslow RL, Greenstein JL. CaMKII-induced shift in modal gating explains L-type Ca(2+) current facilitation: a modeling study. Biophysical Journal. 96: 1770-85. PMID 19254537 DOI: 10.1016/J.Bpj.2008.11.055  0.823
2009 Hashambhoy YL, Winslow RL, Greenstein JL. A Mechanistic, Minimal Model of Ca2+/Calmodulin Dependent Kinase II Signaling in the Cardiac Myocyte Biophysical Journal. 96: 540a. DOI: 10.1016/J.Bpj.2008.12.2789  0.835
2009 Doyle LA, Greenstein JL, Winslow RL. Modeling cAMP-cGMP Crosstalk in the Cardiac Myocyte Biophysical Journal. 96: 304a. DOI: 10.1016/J.Bpj.2008.12.1514  0.624
2008 Maleckar MM, Greenstein JL, Trayanova NA, Giles WR. Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium. Progress in Biophysics and Molecular Biology. 98: 161-70. PMID 19186188 DOI: 10.1016/J.Pbiomolbio.2009.01.010  0.384
2008 Plank G, Zhou L, Greenstein JL, Cortassa S, Winslow RL, O'Rourke B, Trayanova NA. From mitochondrial ion channels to arrhythmias in the heart: computational techniques to bridge the spatio-temporal scales. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 366: 3381-409. PMID 18603526 DOI: 10.1098/Rsta.2008.0112  0.633
2007 Tanskanen AJ, Greenstein JL, Chen A, Sun SX, Winslow RL. Protein geometry and placement in the cardiac dyad influence macroscopic properties of calcium-induced calcium release. Biophysical Journal. 92: 3379-96. PMID 17325016 DOI: 10.1529/Biophysj.106.089425  0.686
2006 Winslow RL, Tanskanen A, Chen M, Greenstein JL. Multiscale modeling of calcium signaling in the cardiac dyad. Annals of the New York Academy of Sciences. 1080: 362-75. PMID 17132795 DOI: 10.1196/Annals.1380.027  0.703
2006 Hinch R, Greenstein JL, Winslow RL. Multi-scale models of local control of calcium induced calcium release. Progress in Biophysics and Molecular Biology. 90: 136-50. PMID 16321427 DOI: 10.1016/J.Pbiomolbio.2005.05.014  0.667
2006 Greenstein JL, Hinch R, Winslow RL. Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte. Biophysical Journal. 90: 77-91. PMID 16214852 DOI: 10.1529/Biophysj.105.065169  0.718
2005 Winslow RL, Cortassa S, Greenstein JL. Using models of the myocyte for functional interpretation of cardiac proteomic data. The Journal of Physiology. 563: 73-81. PMID 15611013 DOI: 10.1113/Jphysiol.2004.080457  0.686
2005 Tanskanen AJ, Greenstein JL, O'Rourke B, Winslow RL. The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations. Biophysical Journal. 88: 85-95. PMID 15501946 DOI: 10.1529/Biophysj.104.051508  0.687
2005 Winslow RL, Hinch R, Greenstein JL. Mechanisms and models of cardiac excitation-contraction coupling Lecture Notes in Mathematics. 1867: 97-131. DOI: 10.1007/11406501_4  0.567
2004 Winslow RL, Greenstein JL. The ongoing journey to understand heart function through integrative modeling. Circulation Research. 95: 1135-6. PMID 15591234 DOI: 10.1161/01.Res.0000151330.81518.73  0.694
2004 Hinch R, Greenstein JL, Tanskanen AJ, Xu L, Winslow RL. A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes. Biophysical Journal. 87: 3723-36. PMID 15465866 DOI: 10.1529/Biophysj.104.049973  0.705
2004 Greenstein JL, Tanskanen AJ, Winslow RL. Modeling the actions of beta-adrenergic signaling on excitation--contraction coupling processes. Annals of the New York Academy of Sciences. 1015: 16-27. PMID 15201146 DOI: 10.1196/Annals.1302.002  0.663
2002 Greenstein JL, Winslow RL. An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. Biophysical Journal. 83: 2918-45. PMID 12496068 DOI: 10.1016/S0006-3495(02)75301-0  0.707
2001 Mazhari R, Greenstein JL, Winslow RL, Marbán E, Nuss HB. Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circulation Research. 89: 33-8. PMID 11440975 DOI: 10.1161/Hh1301.093633  0.573
2001 Winslow RL, Scollan DF, Greenstein JL, Yung CK, Baumgartner W, Bhanot G, Gresh DL, Rogowitz BE. Mapping, modeling, and visual exploration of structure-function relationships in the heart Ibm Systems Journal. 40: 342-359. DOI: 10.1147/sj.402.0342  0.755
2001 Winslow RL, Scollan DF, Greenstein JL, Yung CK, Baumgartner W. J, Bhanot G, Gresh DL, Rogowitz BE. Mapping, modeling, and visual exploration of structure-function relationships in the heart Ibm Systems Journal. 40: 342-359. DOI: 10.1147/Sj.402.0342  0.764
2001 Winslow RL, Greenstein JL, Tomaselli GF, O'Rourke B. Computational models of the failing myocyte: Relating altered gene expression to cellular function Philosophical Transactions of the Royal Society a: Mathematical, Physical and Engineering Sciences. 359: 1187-1200. DOI: 10.1098/Rsta.2001.0825  0.705
2000 Greenstein JL, Wu R, Po S, Tomaselli GF, Winslow RL. Role of the calcium-independent transient outward current I(to1) in shaping action potential morphology and duration. Circulation Research. 87: 1026-33. PMID 11090548 DOI: 10.1161/01.Res.87.11.1026  0.643
2000 Greenstein J, Delmar P, Winslow R. Combining stochastic and deterministic methods to simulate local control by diadic Ca2+ during a ventricular action potential Annals of Biomedical Engineering. 28: S-30.  0.327
2000 Winslow R, Greenstein J, Delmar P. Modulation of the cardiac ventricular myocyte action potential by intracellular calcium Annals of Biomedical Engineering. 28: S-30.  0.553
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