| Year |
Citation |
Score |
| 2019 |
Alvarado W, Ladd Bremer P, Choy A, Dinh HN, Eung A, Gonzalez J, Ly P, Tran T, Nakayama K, Schwans JP, Sorin EJ. Understanding the Enzyme-Ligand Complex: Insights from All-Atom Simulations of Butyrylcholinesterase Inhibition. Journal of Biomolecular Structure & Dynamics. 1-17. PMID 30909811 DOI: 10.1080/07391102.2019.1596836 |
0.351 |
|
| 2018 |
Chang TC, Park JH, Colquhoun AN, Khoury CB, Seangmany NA, Schwans JP. Evaluating the catalytic importance of a conserved Glu97 residue in triosephosphate isomerase. Biochemical and Biophysical Research Communications. PMID 30268499 DOI: 10.1016/J.Bbrc.2018.09.076 |
0.336 |
|
| 2018 |
Pinney M, Natarajan A, Yabukarski F, Sanchez DM, Liu F, Liang R, Doukov TI, Schwans JP, Martínez TJ, Herschlag D. Structural Coupling Throughout the Active Site Hydrogen Bond Networks of Ketosteroid Isomerase and Photoactive Yellow Protein. Journal of the American Chemical Society. PMID 29990421 DOI: 10.1021/Jacs.8B01596 |
0.328 |
|
| 2017 |
Nakayama K, Schwans JP, Sorin EJ, Tran T, Gonzalez J, Arteaga E, McCoy S, Alvarado W. Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors. Bioorganic & Medicinal Chemistry. PMID 28416102 DOI: 10.1016/J.Bmc.2017.04.002 |
0.313 |
|
| 2016 |
Gonzalez J, Ramirez J, Schwans JP. Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase. Amino Acids. PMID 27522651 DOI: 10.1007/S00726-016-2310-4 |
0.307 |
|
| 2014 |
Natarajan A, Schwans JP, Herschlag D. Using unnatural amino acids to probe the energetics of oxyanion hole hydrogen bonds in the ketosteroid isomerase active site. Journal of the American Chemical Society. 136: 7643-54. PMID 24787954 DOI: 10.1021/Ja413174B |
0.338 |
|
| 2014 |
Schwans JP, Hanoian P, Lengerich BJ, Sunden F, Gonzalez A, Tsai Y, Hammes-Schiffer S, Herschlag D. Experimental and computational mutagenesis to investigate the positioning of a general base within an enzyme active site. Biochemistry. 53: 2541-55. PMID 24597914 DOI: 10.1021/Bi401671T |
0.362 |
|
| 2013 |
Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Uncovering the determinants of a highly perturbed tyrosine pKa in the active site of ketosteroid isomerase. Biochemistry. 52: 7840-55. PMID 24151972 DOI: 10.1021/Bi401083B |
0.42 |
|
| 2013 |
Schwans JP, Sunden F, Lassila JK, Gonzalez A, Tsai Y, Herschlag D. Use of anion-aromatic interactions to position the general base in the ketosteroid isomerase active site. Proceedings of the National Academy of Sciences of the United States of America. 110: 11308-13. PMID 23798413 DOI: 10.1073/Pnas.1206710110 |
0.415 |
|
| 2013 |
Sigala PA, Fafarman AT, Schwans JP, Fried SD, Fenn TD, Caaveiro JM, Pybus B, Ringe D, Petsko GA, Boxer SG, Herschlag D. Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site. Proceedings of the National Academy of Sciences of the United States of America. 110: E2552-61. PMID 23798390 DOI: 10.1073/Pnas.1302191110 |
0.354 |
|
| 2013 |
Ruben EA, Schwans JP, Sonnett M, Natarajan A, Gonzalez A, Tsai Y, Herschlag D. Ground state destabilization from a positioned general base in the ketosteroid isomerase active site. Biochemistry. 52: 1074-81. PMID 23311398 DOI: 10.1021/Bi301348X |
0.329 |
|
| 2012 |
Fafarman AT, Sigala PA, Schwans JP, Fenn TD, Herschlag D, Boxer SG. Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase. Proceedings of the National Academy of Sciences of the United States of America. 109: E299-308. PMID 22308339 DOI: 10.1073/Pnas.1111566109 |
0.33 |
|
| 2011 |
Schwans JP, Sunden F, Gonzalez A, Tsai Y, Herschlag D. Evaluating the catalytic contribution from the oxyanion hole in ketosteroid isomerase. Journal of the American Chemical Society. 133: 20052-5. PMID 22053826 DOI: 10.1021/Ja208050T |
0.377 |
|
| 2011 |
Forconi M, Schwans JP, Porecha RH, Sengupta RN, Piccirilli JA, Herschlag D. 2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA. Chemistry & Biology. 18: 949-54. PMID 21867910 DOI: 10.1016/J.Chembiol.2011.07.014 |
0.629 |
|
| 2009 |
Schwans JP, Kraut DA, Herschlag D. Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase. Proceedings of the National Academy of Sciences of the United States of America. 106: 14271-5. PMID 19706511 DOI: 10.1073/Pnas.0901032106 |
0.359 |
|
| 2008 |
Das R, Kudaravalli M, Jonikas M, Laederach A, Fong R, Schwans JP, Baker D, Piccirilli JA, Altman RB, Herschlag D. Structural inference of native and partially folded RNA by high-throughput contact mapping. Proceedings of the National Academy of Sciences of the United States of America. 105: 4144-9. PMID 18322008 DOI: 10.1073/Pnas.0709032105 |
0.652 |
|
| 2004 |
Schwans JP, Li NS, Piccirilli JA. A packing-density metric for exploring the interior of folded RNA molecules. Angewandte Chemie (International Ed. in English). 43: 3033-7. PMID 15188472 DOI: 10.1002/Anie.200353575 |
0.608 |
|
| 2004 |
Gordon PM, Fong R, Deb SK, Li NS, Schwans JP, Ye JD, Piccirilli JA. New strategies for exploring RNA's 2'-OH expose the importance of solvent during group II intron catalysis. Chemistry & Biology. 11: 237-46. PMID 15123285 DOI: 10.1016/J.Chembiol.2004.02.011 |
0.659 |
|
| 2003 |
Schwans JP, Cortez CN, Olvera JM, Piccirilli JA. 2'-mercaptonucleotide interference reveals regions of close packing within folded RNA molecules. Journal of the American Chemical Society. 125: 10012-8. PMID 12914464 DOI: 10.1021/Ja035175Y |
0.647 |
|
| 2000 |
Hamm ML, Schwans JP, Piccirilli JA. The hammerhead ribozyme catalyzes the deglycosylation of 2'- mercaptocytidine [6] Journal of the American Chemical Society. 122: 4223-4224. DOI: 10.1021/Ja993027V |
0.54 |
|
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