Year |
Citation |
Score |
2005 |
Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/Jneurosci.4883-04.2005 |
0.524 |
|
2004 |
Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 43: 323-33. PMID 14717586 DOI: 10.1021/Bi035748J |
0.753 |
|
2003 |
Kimberly WT, Wolfe MS. Identity and function of gamma-secretase. Journal of Neuroscience Research. 74: 353-60. PMID 14598311 DOI: 10.1002/jnr.10736 |
0.565 |
|
2003 |
Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiology of Disease. 14: 194-204. PMID 14572442 DOI: 10.1016/S0969-9961(03)00123-2 |
0.763 |
|
2003 |
LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. The Journal of Biological Chemistry. 278: 37213-22. PMID 12857757 DOI: 10.1074/Jbc.M303941200 |
0.75 |
|
2003 |
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/Bi027375C |
0.737 |
|
2003 |
Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 10: 51-61. PMID 12762144 DOI: 10.3109/13506120308995259 |
0.457 |
|
2003 |
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 6382-7. PMID 12740439 DOI: 10.1073/Pnas.1037392100 |
0.759 |
|
2003 |
Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 42: 137-44. PMID 12515548 DOI: 10.1021/bi026888g |
0.67 |
|
2003 |
Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 79-81. PMID 12424225 DOI: 10.1096/Fj.02-0394Fje |
0.415 |
|
2002 |
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. The Journal of Biological Chemistry. 277: 35113-7. PMID 12130643 DOI: 10.1074/Jbc.M204446200 |
0.731 |
|
2002 |
Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nature Cell Biology. 4: E110-1; author reply. PMID 11988746 DOI: 10.1038/ncb0502-e110b |
0.559 |
|
2002 |
Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proceedings of the National Academy of Sciences of the United States of America. 99: 2720-5. PMID 11867728 DOI: 10.1073/pnas.052436599 |
0.696 |
|
2001 |
Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. The Journal of Biological Chemistry. 276: 40288-92. PMID 11544248 DOI: 10.1074/jbc.C100447200 |
0.622 |
|
2000 |
Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiology of Disease. 7: 673-81. PMID 11114265 DOI: 10.1006/nbdi.2000.0322 |
0.617 |
|
2000 |
Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/Pnas.97.16.9299 |
0.657 |
|
2000 |
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. Journal of Neurochemistry. 75: 583-93. PMID 10899933 DOI: 10.1046/J.1471-4159.2000.0750583.X |
0.647 |
|
2000 |
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nature Cell Biology. 2: 428-34. PMID 10878808 DOI: 10.1038/35017062 |
0.646 |
|
2000 |
Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. The Journal of Biological Chemistry. 275: 3173-8. PMID 10652302 DOI: 10.1074/jbc.275.5.3173 |
0.655 |
|
2000 |
Esler WP, Diehl TS, Ostaszewski BL, Moore CL, Xia W, Kimberly WT, Selkoe DJ, Wolfe MS. Toward identification of gamma-secretase using transition-state analogue inhibitors Neurobiology of Aging. 21: 278. DOI: 10.1016/S0197-4580(00)83201-7 |
0.471 |
|
1999 |
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398: 513-7. PMID 10206644 DOI: 10.1038/19077 |
0.672 |
|
1998 |
Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/Bi9816195 |
0.722 |
|
Show low-probability matches. |