| Year |
Citation |
Score |
| 2024 |
Zhang J, Kong X, Yang HJ, Mohibi S, Lucchesi CA, Zhang W, Chen X. Ninjurin 2, a Cell Adhesion Molecule and a Target of p53, Modulates Wild-Type p53 in Growth Suppression and Mutant p53 in Growth Promotion. Cancers. 16. PMID 38201656 DOI: 10.3390/cancers16010229 |
0.441 |
|
| 2023 |
Lucchesi CA, Zhang J, Gao M, Shaw J, Chen X. Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression. Molecular Cancer Therapeutics. PMID 36940176 DOI: 10.1158/1535-7163.MCT-22-0627 |
0.368 |
|
| 2022 |
Mohibi S, Chen X, Zhang J. ZFP14 Regulates Cancer Cell Growth and Migration by Modulating p53 Protein Stability as Part of the MDM2 E3 Ubiquitin Ligase Complex. Cancers. 14. PMID 36358645 DOI: 10.3390/cancers14215226 |
0.483 |
|
| 2022 |
Rabow Z, Laubach K, Kong X, Shen T, Mohibi S, Zhang J, Fiehn O, Chen X. p73α1, an Isoform of the p73 Tumor Suppressor, Modulates Lipid Metabolism and Cancer Cell Growth via Stearoyl-CoA Desaturase-1. Cells. 11. PMID 36010592 DOI: 10.3390/cells11162516 |
0.325 |
|
| 2022 |
Laubach KN, Yan W, Kong X, Sun W, Chen M, Zhang J, Chen X. p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123202119. PMID 35617425 DOI: 10.1073/pnas.2123202119 |
0.354 |
|
| 2022 |
Lucchesi CA, Zhang J, Vasilatis DM, Yip E, Chen X. Optimization of eIF4E-Binding Peptide Pep8 to Disrupt the RBM38-eIF4E Complex for Induction of p53 and Tumor Suppression. Frontiers in Oncology. 12: 893062. PMID 35574389 DOI: 10.3389/fonc.2022.893062 |
0.321 |
|
| 2022 |
Zhang Y, Mohibi S, Vasilatis DM, Chen M, Zhang J, Chen X. Ferredoxin reductase and p53 are necessary for lipid homeostasis and tumor suppression through the ABCA1-SREBP pathway. Oncogene. PMID 35121827 DOI: 10.1038/s41388-021-02100-0 |
0.333 |
|
| 2021 |
Laubach K, Zhang J, Chen X. The p53 Family: A Role in Lipid and Iron Metabolism. Frontiers in Cell and Developmental Biology. 9: 715974. PMID 34395447 DOI: 10.3389/fcell.2021.715974 |
0.397 |
|
| 2021 |
Mohibi S, Zhang J, Chen M, Chen X. Mice deficient in the RNA binding protein Zfp871 are prone to early death and steatohepatitis in part through the p53-Mdm2 axis. Molecular Cancer Research : McR. PMID 34257081 DOI: 10.1158/1541-7786.MCR-21-0239 |
0.438 |
|
| 2021 |
Kong X, Wang D, Sun W, Chen M, Chen J, Shi J, Zhang J, Chen X. Small Proline-Rich Protein 2A and 2D Are Regulated by the RBM38-p73 Axis and Associated with p73-Dependent Suppression of Chronic Inflammation. Cancers. 13. PMID 34204113 DOI: 10.3390/cancers13112829 |
0.309 |
|
| 2021 |
Sun W, Laubach K, Lucchessi C, Zhang Y, Chen M, Zhang J, Chen X. Fine-tuning p53 activity by modulating the interaction between eukaryotic translation initiation factor eIF4E and RNA-binding protein RBM38. Genes & Development. PMID 33664057 DOI: 10.1101/gad.346148.120 |
0.41 |
|
| 2020 |
Zhang J, Kong X, Zhang Y, Sun W, Wang J, Chen M, Chen X. FDXR regulates TP73 tumor suppressor via IRP2 to modulate aging and tumor suppression. The Journal of Pathology. PMID 32304229 DOI: 10.1002/Path.5451 |
0.474 |
|
| 2020 |
Zhang Y, Feng X, Zhang J, Chen X. Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression. Molecular Cancer Research : McR. PMID 32276991 DOI: 10.1158/1541-7786.Mcr-19-1104 |
0.449 |
|
| 2020 |
Mohibi S, Zhang J, Chen X. PABPN1, a target of p63, modulates keratinocyte differentiation through regulation of p63α mRNA translation. The Journal of Investigative Dermatology. PMID 32243883 DOI: 10.1016/J.Jid.2020.03.942 |
0.471 |
|
| 2019 |
Zhang J, Kong X, Zhang Y, Sun W, Xu E, Chen X. Mdm2 is a target and mediator of IRP2 in cell growth control. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31907996 DOI: 10.1096/Fj.201902278Rr |
0.389 |
|
| 2019 |
Zhang J, Sun W, Kong X, Zhang Y, Yang HJ, Ren C, Jiang Y, Chen M, Chen X. Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1. Proceedings of the National Academy of Sciences of the United States of America. PMID 31712410 DOI: 10.1073/Pnas.1913919116 |
0.53 |
|
| 2019 |
Cai D, Wang J, Gao B, Li J, Wu F, Zou JX, Xu J, Jiang Y, Zou H, Huang Z, Borowsky AD, Bold RJ, Lara PN, Li JJ, Chen X, et al. RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype. Nature Communications. 10: 4621. PMID 31604910 DOI: 10.1038/S41467-019-12529-3 |
0.306 |
|
| 2019 |
Zhang Y, Feng X, Zhang J, Chen M, Huang E, Chen X. Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis. Oncogene. PMID 31332290 DOI: 10.1038/S41388-019-0876-5 |
0.485 |
|
| 2019 |
Zhang J, Sun W, Ren C, Kong X, Yan W, Chen X. A PolH transcript with a short 3'UTR enhances PolH expression and mediates cisplatin resistance. Cancer Research. PMID 31064846 DOI: 10.1158/0008-5472.Can-18-3928 |
0.35 |
|
| 2018 |
Lucchesi CA, Zhang J, Ma B, Chen M, Chen X. Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression. Cancer Research. PMID 30591552 DOI: 10.1158/0008-5472.Can-18-2209 |
0.48 |
|
| 2018 |
Zhang Y, Feng X, Sun W, Zhang J, Chen X. Serine-195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex. The Journal of Biological Chemistry. PMID 30567739 DOI: 10.1074/Jbc.Ra118.005779 |
0.45 |
|
| 2018 |
Ming X, Bao C, Hong T, Yang Y, Chen X, Jung YS, Qian Y. Clusterin, a novel DEC1 target, modulates DNA damage-mediated cell death. Molecular Cancer Research : McR. PMID 30002194 DOI: 10.1158/1541-7786.Mcr-18-0070 |
0.604 |
|
| 2018 |
Jiang Y, Xu E, Zhang J, Chen M, Flores E, Chen X. The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. Oncogene. PMID 29520104 DOI: 10.1038/S41388-018-0176-5 |
0.475 |
|
| 2018 |
Zhang M, Zhang Y, Xu E, Mohibi S, de Anda DM, Jiang Y, Zhang J, Chen X. Rbm24, a target of p53, is necessary for proper expression of p53 and heart development. Cell Death and Differentiation. PMID 29358667 DOI: 10.1038/S41418-017-0029-8 |
0.449 |
|
| 2018 |
Zhang J, Xu E, Ren C, Yang HJ, Zhang Y, Sun W, Kong X, Zhang W, Chen M, Huang EC, Chen X. Genetic ablation of Rbm38 promotes lymphomagenesis in the context of mutant p53 by downregulating PTEN. Cancer Research. PMID 29330147 DOI: 10.1158/0008-5472.Can-17-2457 |
0.485 |
|
| 2018 |
Mohibi S, Zhang J, Chen X. Abstract 4440: Differential regulation of p63 isoforms by alternative polyadenylation Cancer Research. 78: 4440-4440. DOI: 10.1158/1538-7445.Am2018-4440 |
0.494 |
|
| 2017 |
Yan W, Zhang Y, Chen X. TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression. Oncotarget. 8: 78327-78339. PMID 29108232 DOI: 10.18632/Oncotarget.18463 |
0.448 |
|
| 2017 |
Yang HJ, Zhang J, Yan W, Cho SJ, Lucchesi C, Chen M, Huang EC, Scoumanne A, Zhang W, Chen X. Ninjurin 1 has two opposing functions in tumorigenesis in a p53-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 114: 11500-11505. PMID 29073078 DOI: 10.1073/Pnas.1711814114 |
0.525 |
|
| 2017 |
Zhang Y, Qian Y, Zhang J, Yan W, Jung YS, Chen M, Huang E, Lloyd K, Duan Y, Wang J, Liu G, Chen X. Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2. Genes & Development. PMID 28747430 DOI: 10.1101/Gad.299388.117 |
0.581 |
|
| 2017 |
Yan W, Zhang Y, Chen X. TAp63γ and ΔNp63γ are regulated by RBM38 via mRNA stability and have an opposing function in growth suppression. Oncotarget. PMID 28645112 DOI: 10.18632/oncotarget.18463 |
0.34 |
|
| 2017 |
Zhang Y, Yan W, Zhang J, Chen X. Abstract 4491: Modulation of p63 expression by phosphorylation of RBM38 at S195 via miR-203 Cancer Research. 77: 4491-4491. DOI: 10.1158/1538-7445.Am2017-4491 |
0.444 |
|
| 2016 |
Lucchesi C, Zhang J, Chen X. Modulation of the p53 family network by RNA-binding proteins. Translational Cancer Research. 5: 676-684. PMID 28794999 DOI: 10.21037/Tcr.2016.08.30 |
0.523 |
|
| 2016 |
Zhang M, Zhang J, Yan W, Chen X. p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability. Oncotarget. PMID 27825141 DOI: 10.18632/Oncotarget.13126 |
0.5 |
|
| 2016 |
Wang J, Wang H, Wang LY, Cai D, Duan Z, Zhang Y, Chen P, Zou JX, Xu J, Chen X, Kung HJ, Chen HW. Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy. Cell Death and Differentiation. PMID 27612013 DOI: 10.1038/Cdd.2016.92 |
0.38 |
|
| 2016 |
Zhang J, Lucchesi C, Chen X. A New Function for p53 Tetramerization Domain in Cell Fate Control. Cell Cycle (Georgetown, Tex.). 0. PMID 27355441 DOI: 10.1080/15384101.2016.1204868 |
0.4 |
|
| 2016 |
Raina K, Lu J, Qian Y, Altieri M, Gordon D, Rossi AM, Wang J, Chen X, Dong H, Siu K, Winkler JD, Crew AP, Crews CM, Coleman KG. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27274052 DOI: 10.1073/Pnas.1521738113 |
0.483 |
|
| 2016 |
Chen J, Li W, Jin E, He Q, Yan W, Yang H, Gong S, Guo Y, Fu S, Chen X, Ye S, Qian Y. The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2. Research in Veterinary Science. 106: 159-64. PMID 27234554 DOI: 10.1016/j.rvsc.2015.10.012 |
0.506 |
|
| 2016 |
Ma KG, Lv J, Hu XD, Shi LL, Chang KW, Chen XL, Qian YH, Yang WN, Qu QM. The p38 mitogen-activated protein kinase signaling pathway is involved in regulating low-density lipoprotein receptor-related protein 1-mediated β-amyloid protein internalization in mouse brain. The International Journal of Biochemistry & Cell Biology. PMID 27163530 DOI: 10.1016/j.biocel.2016.04.019 |
0.517 |
|
| 2016 |
Yi X, Sun J, Li L, Wei Q, Qian Y, Chen X, Ma L. 1,25-Dihydroxyvitamin D3 Deficiency is Involved in the Pathogenesis of Diabetic Retinopathy in the Uygur Population of China. Iubmb Life. PMID 27080220 DOI: 10.1002/iub.1501 |
0.434 |
|
| 2016 |
Qian Y, Zhang Y, Zhong P, Peng K, Xu Z, Chen X, Lu K, Chen G, Li X, Liang G. Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity. Journal of Cellular and Molecular Medicine. PMID 27019072 DOI: 10.1111/jcmm.12832 |
0.452 |
|
| 2016 |
Chen X, Du Y, Lin X, Qian Y, Zhou T, Huang Z. CD4+CD25+ regulatory T cells in tumor immunity. International Immunopharmacology. 34: 244-249. PMID 26994448 DOI: 10.1016/j.intimp.2016.03.009 |
0.481 |
|
| 2016 |
Chen XF, Qian J, Pei D, Zhou C, Røe OD, Zhu F, He SH, Qian YY, Zhou Y, Xu J, Xu J, Li X, Ping GQ, Liu YQ, Wang P, et al. Prognostic value of perioperative leukocyte count in resectable gastric cancer. World Journal of Gastroenterology. 22: 2818-27. PMID 26973420 DOI: 10.3748/wjg.v22.i9.2818 |
0.429 |
|
| 2016 |
Qian J, Qian Y, Wang J, Gu B, Pei D, He S, Zhu F, Røe OD, Xu J, Liu L, Gu Y, Guo R, Yin Y, Shu Y, Chen X. A clinical prognostic scoring system for resectable gastric cancer to predict survival and benefit from paclitaxel- or oxaliplatin-based adjuvant chemotherapy. Drug Design, Development and Therapy. 10: 241-58. PMID 26966350 DOI: 10.2147/DDDT.S88743 |
0.425 |
|
| 2016 |
Xu C, Liu R, Zhang Q, Chen X, Qian Y, Fang W. The diversification of evolutionarily conserved MAPK cascades correlates with the evolution of fungal species and development of lifestyles. Genome Biology and Evolution. PMID 26957028 DOI: 10.1093/gbe/evw051 |
0.496 |
|
| 2016 |
Yan W, Scoumanne A, Jung YS, Xu E, Zhang J, Zhang Y, Ren C, Sun P, Chen X. Mice deficient in poly(C)-binding protein 4 are susceptible to spontaneous tumors through increased expression of ZFP871 that targets p53 for degradation. Genes & Development. PMID 26915821 DOI: 10.1101/Gad.271890.115 |
0.54 |
|
| 2016 |
Ren C, Zhang J, Yan W, Zhang Y, Chen X. RNA-Binding Protein PCBP2 regulates p73 expression and p73-dependent antioxidant defense. The Journal of Biological Chemistry. PMID 26907686 DOI: 10.1074/Jbc.M115.712125 |
0.509 |
|
| 2016 |
Cheng C, Zhou Y, Li H, Xiong T, Li S, Bi Y, Kong P, Wang F, Cui H, Li Y, Fang X, Yan T, Li Y, Wang J, Yang B, ... Chen X, et al. Whole-Genome Sequencing Reveals Diverse Models of Structural Variations in Esophageal Squamous Cell Carcinoma. American Journal of Human Genetics. PMID 26833333 DOI: 10.1016/j.ajhg.2015.12.013 |
0.471 |
|
| 2016 |
Yang HJ, Cho SJ, Zhang J, Yan W, Chen X. Abstract 675: Ninjurin1, a target of p53, modulates p53-dependent tumor suppressionin vivo Cancer Research. 76: 675-675. DOI: 10.1158/1538-7445.Am2016-675 |
0.516 |
|
| 2016 |
Wang J, Wang H, Wang L, Cai D, Duan Z, Chen P, Zou JX, Xu J, Chen X, Kung H, Chen H. Abstract 3062: Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy Cancer Research. 76: 3062-3062. DOI: 10.1158/1538-7445.Am2016-3062 |
0.383 |
|
| 2015 |
Chen X, Xu C, Qian Y, Liu R, Zhang Q, Zeng G, Zhang X, Zhao H, Fang W. MAPK cascade-mediated regulation of pathogenicity, conidiation and tolerance to abiotic stresses in the entomopathogenic fungus Metarhizium robertsii. Environmental Microbiology. PMID 26714892 DOI: 10.1111/1462-2920.13198 |
0.498 |
|
| 2015 |
Lv Y, Qian Y, Fu L, Chen X, Zhong H, Wei X. Hydroxysafflor Yellow A Exerts Neuroprotective Effects In Cerebral Ischemia Reperfusion-injured Mice By Suppressing The Innate Immune TLR4-inducing Pathway. European Journal of Pharmacology. PMID 26607471 DOI: 10.1016/j.ejphar.2015.11.036 |
0.495 |
|
| 2015 |
Song B, Cui H, Li Y, Cheng C, Yang B, Wang F, Kong P, Li H, Zhang L, Jia Z, Bi Y, Wang J, Zhou Y, Liu J, Wang J, ... ... Chen X, et al. Mutually exclusive mutations in NOTCH1 and PIK3CA associated with clinical prognosis and chemotherapy responses of esophageal squamous cell carcinoma in China. Oncotarget. PMID 26528858 DOI: 10.18632/oncotarget.6120 |
0.443 |
|
| 2015 |
Granchi C, Qian Y, Lee HY, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo F. Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells. Chemmedchem. PMID 26332543 DOI: 10.1002/Cmdc.201500320 |
0.467 |
|
| 2015 |
Qian Y, Chen XN, Shi H, Xie J, Chen N. Refractory Abdominal Pain in a Hemodialysis Patient. Case Reports in Nephrology and Dialysis. 5: 145-51. PMID 26266246 DOI: 10.1159/000431084 |
0.411 |
|
| 2015 |
Hao L, Shi Y, Xiao R, Qian Y, Chen X. Study on sampled waveguide grating with anti-symmetric periodic structure. Optics Express. 23: 15784-91. PMID 26193557 DOI: 10.1364/OE.23.015784 |
0.402 |
|
| 2015 |
Tang J, Qian Y, Li H, Kopecky BJ, Ding D, Ou HC, DeCook R, Chen X, Sun Z, Kobel M, Bao J. Canertinib induces ototoxicity in three preclinical models. Hearing Research. 328: 59-66. PMID 26163095 DOI: 10.1016/J.Heares.2015.07.002 |
0.494 |
|
| 2015 |
Zhang Y, Young A, Zhang J, Chen X. P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition. Oncotarget. 6: 13994-4004. PMID 26101856 DOI: 10.18632/Oncotarget.4374 |
0.489 |
|
| 2015 |
Liu X, Malki A, Cao Y, Li Y, Qian Y, Wang X, Chen X. Glucose- and Triglyceride-lowering Dietary Penta-O-galloyl-α-D-Glucose Reduces Expression of PPARγ and C/EBPα, Induces p21-Mediated G1 Phase Cell Cycle Arrest, and Inhibits Adipogenesis in 3T3-L1 Preadipocytes. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association. 123: 308-16. PMID 25988880 DOI: 10.1055/s-0035-1548789 |
0.489 |
|
| 2015 |
Pan W, Zhu S, Dai D, Liu Z, Li D, Li B, Gagliani N, Zheng Y, Tang Y, Weirauch MT, Chen X, Zhu W, Wang Y, Chen B, Qian Y, et al. MiR-125a targets effector programs to stabilize Treg-mediated immune homeostasis. Nature Communications. 6: 7096. PMID 25963922 DOI: 10.1038/Ncomms8096 |
0.431 |
|
| 2015 |
Zhao Y, Shen L, Chen X, Qian Y, Zhou Q, Wang Y, Li K, Liu M, Zhang S, Huang X. High expression of PKM2 as a poor prognosis indicator is associated with radiation resistance in cervical cancer. Histology and Histopathology. 11627. PMID 25936600 DOI: 10.14670/HH-11-627 |
0.487 |
|
| 2015 |
He F, Luo J, Zhang Z, Luo Z, Fan L, He Y, Wen J, Zhu D, Gao J, Wang Y, Qian Y, Zhou H, Chen X, Zhang W. The RGS2 (-391, C>G) genetic variation correlates to antihypertensive drug responses in Chinese patients with essential hypertension. Plos One. 10: e0121483. PMID 25849301 DOI: 10.1371/Journal.Pone.0121483 |
0.454 |
|
| 2015 |
Qian Y, Shi D, Qiu J, Zhu F, Qian J, He S, Shu Y, Yin Y, Chen X. ObRb downregulation increases breast cancer cell sensitivity to tamoxifen. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 25846733 DOI: 10.1007/s13277-015-3375-5 |
0.523 |
|
| 2015 |
Zhang M, Xu E, Zhang J, Chen X. PPM1D phosphatase, a target of p53 and RBM38 RNA-binding protein, inhibits p53 mRNA translation via dephosphorylation of RBM38. Oncogene. PMID 25823026 DOI: 10.1038/Onc.2015.31 |
0.508 |
|
| 2015 |
Chen Z, Smith M, Du H, Guo Y, Clarke R, Zheng B, Collins R, Chen J, Qian Y, Wang X, Chen X, Tian X, Wang X, Peto R, Li L, et al. Blood pressure in relation to general and central adiposity among 500 000 adult Chinese men and women. International Journal of Epidemiology. PMID 25747585 DOI: 10.1093/ije/dyv012 |
0.406 |
|
| 2015 |
Qian Y, Pei D, Cheng T, Wu C, Pu X, Chen X, Liu Y, Shen H, Zhang W, Shu Y. CD137 ligand-mediated reverse signaling inhibits proliferation and induces apoptosis in non-small cell lung cancer. Medical Oncology (Northwood, London, England). 32: 44. PMID 25631633 DOI: 10.1007/s12032-015-0499-9 |
0.563 |
|
| 2015 |
Cho SJ, Teng IF, Zhang M, Yin T, Jung YS, Zhang J, Chen X. Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNA-binding protein and a p53 family target, via mRNA translation. Oncotarget. 6: 305-16. PMID 25622105 DOI: 10.18632/Oncotarget.2786 |
0.389 |
|
| 2015 |
Zhang W, Zhu J, Song X, Xu Z, Xue X, Chen X, Yang X, Li Y, Dong X, Zhou S, Li W, Qian Y, Liu F, Su C. An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum. Parasites & Vectors. 8: 37. PMID 25604731 DOI: 10.1186/s13071-015-0650-7 |
0.447 |
|
| 2015 |
Cao R, Zhang J, Zhang M, Chen X. PPM1D regulates p21 expression via dephoshporylation at serine 123. Cell Cycle (Georgetown, Tex.). 14: 641-7. PMID 25590690 DOI: 10.4161/15384101.2014.994922 |
0.489 |
|
| 2015 |
Liu Y, Chen X, Gu Y, Zhu L, Qian Y, Pei D, Zhang W, Shu Y. FOXM1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and mediates sensitivity to cisplatin in A549 cells via the JNK/mitochondrial pathway. Neoplasma. 62: 61-71. PMID 25563368 DOI: 10.4149/neo_2015_008 |
0.529 |
|
| 2015 |
Huang X, Qian Y, Wu H, Xie X, Zhou Q, Wang Y, Kuang W, Shen L, Li K, Su J, Shen L, Chen X. Aberrant expression of osteopontin and E-cadherin indicates radiation resistance and poor prognosis for patients with cervical carcinoma. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 63: 88-98. PMID 25380749 DOI: 10.1369/0022155414561329 |
0.496 |
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| 2015 |
Chen X, Qian Y, Wu S. The Warburg effect: evolving interpretations of an established concept. Free Radical Biology & Medicine. 79: 253-63. PMID 25277420 DOI: 10.1016/J.Freeradbiomed.2014.08.027 |
0.467 |
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| 2014 |
Qian YY, Liu XY, Pei D, Xu JL, Shen H, Chen XF, Liu YQ, Shen LZ, Shu YQ. The XPD Lys751Gln polymorphism has predictive value in colorectal cancer patients receiving oxaliplatin-based chemotherapy: a systemic review and meta-analysis. Asian Pacific Journal of Cancer Prevention : Apjcp. 15: 9699-706. PMID 25520091 DOI: 10.7314/APJCP.2014.15.22.9699 |
0.433 |
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| 2014 |
Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff RD, Imai DM, Wisner E, Chen X. Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proceedings of the National Academy of Sciences of the United States of America. 111: 18637-42. PMID 25512531 DOI: 10.1073/Pnas.1415607112 |
0.473 |
|
| 2014 |
Kurmi OP, Li L, Smith M, Augustyn M, Chen J, Collins R, Guo Y, Han Y, Qin J, Xu G, Wang J, Bian Z, Zhou G, Davis K, Peto R, ... ... Chen X, ... ... Chen X, et al. Regional variations in the prevalence and misdiagnosis of air flow obstruction in China: baseline results from a prospective cohort of the China Kadoorie Biobank (CKB). Bmj Open Respiratory Research. 1: e000025. PMID 25478177 DOI: 10.1136/bmjresp-2014-000025 |
0.4 |
|
| 2014 |
Qian YY, Liu XY, Wu Q, Song X, Chen XF, Liu YQ, Pei D, Shen LZ, Shu YQ. The ERCC1 C118T polymorphism predicts clinical outcomes of colorectal cancer patients receiving oxaliplatin-based chemotherapy: a meta-analysis based on 22 studies. Asian Pacific Journal of Cancer Prevention : Apjcp. 15: 8383-90. PMID 25339033 |
0.43 |
|
| 2014 |
Ren C, Cho SJ, Jung YS, Chen X. DNA polymerase η is regulated by poly(rC)-binding protein 1 via mRNA stability. The Biochemical Journal. 464: 377-86. PMID 25268038 DOI: 10.1042/Bj20141164 |
0.388 |
|
| 2014 |
Xu C, Zhang X, Qian Y, Chen X, Liu R, Zeng G, Zhao H, Fang W. A high-throughput gene disruption methodology for the entomopathogenic fungus Metarhizium robertsii. Plos One. 9: e107657. PMID 25222118 DOI: 10.1371/journal.pone.0107657 |
0.45 |
|
| 2014 |
Yang WN, Ma KG, Chen XL, Shi LL, Bu G, Hu XD, Han H, Liu Y, Qian YH. Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells. Neuroscience. 278: 276-90. PMID 25168732 DOI: 10.1016/j.neuroscience.2014.08.013 |
0.502 |
|
| 2014 |
Yan W, Jung YS, Zhang Y, Chen X. Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase. Plos One. 9: e103497. PMID 25116336 DOI: 10.1371/Journal.Pone.0103497 |
0.512 |
|
| 2014 |
Chen X, Hu H, Qian Y, Shu J. Relation of late gadolinium enhancement in cardiac magnetic resonance on the diastolic volume recovery of left ventricle with hypertrophic cardiomyopathy. Journal of Thoracic Disease. 6: 988-94. PMID 25093097 DOI: 10.3978/j.issn.2072-1439.2014.06.37 |
0.473 |
|
| 2014 |
Han X, Yang Q, Lin L, Xu C, Zheng C, Chen X, Han Y, Li M, Cao W, Cao K, Chen Q, Xu G, Zhang Y, Zhang J, Schneider RJ, et al. Interleukin-17 enhances immunosuppression by mesenchymal stem cells. Cell Death and Differentiation. 21: 1758-68. PMID 25034782 DOI: 10.1038/Cdd.2014.85 |
0.443 |
|
| 2014 |
Qian Y, Wang X, Liu Y, Li Y, Colvin RA, Tong L, Wu S, Chen X. Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells Cancer Letters. 351: 242-251. PMID 24973521 DOI: 10.1016/J.Canlet.2014.06.008 |
0.479 |
|
| 2014 |
Qian Y, Ren H, Wang ZH, Li X, Chen XN, Chen N. Staging and risk factors of chronic kidney disease of outpatients in Shanghai. Renal Failure. 36: 1018-22. PMID 24940809 DOI: 10.3109/0886022X.2014.926923 |
0.399 |
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| 2014 |
Pei D, Zhu F, Chen X, Qian J, He S, Qian Y, Shen H, Liu Y, Xu J, Shu Y. Pre-adjuvant chemotherapy leukocyte count may predict the outcome for advanced gastric cancer after radical resection. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 68: 213-7. PMID 24581723 DOI: 10.1016/j.biopha.2014.01.008 |
0.549 |
|
| 2014 |
Wei ZH, Duan YY, Qian YQ, Guo XF, Li YJ, Jin SH, Zhou ZX, Shan SY, Wang CR, Chen XJ, Zheng Y, Zhong JJ. Screening of Ganoderma strains with high polysaccharides and ganoderic acid contents and optimization of the fermentation medium by statistical methods. Bioprocess and Biosystems Engineering. 37: 1789-97. PMID 24577738 DOI: 10.1007/s00449-014-1152-2 |
0.404 |
|
| 2014 |
Qian Y, Zhang J, Jung YS, Chen X. DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression. Plos One. 9: e84015. PMID 24404147 DOI: 10.1371/Journal.Pone.0084015 |
0.61 |
|
| 2014 |
Xu E, Zhang J, Zhang M, Jiang Y, Cho SJ, Chen X. RNA-binding protein RBM24 regulates p63 expression via mRNA stability. Molecular Cancer Research : McR. 12: 359-69. PMID 24375645 DOI: 10.1158/1541-7786.Mcr-13-0526 |
0.516 |
|
| 2014 |
Jiang Y, Zhang M, Qian Y, Xu E, Zhang J, Chen X. Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. The Journal of Biological Chemistry. 289: 3164-75. PMID 24356969 DOI: 10.1074/Jbc.M113.524413 |
0.694 |
|
| 2014 |
Zou JX, Wang J, Duan Z, Chen H, Kung H, Chen X, Murphy LC, Borowsky A. Abstract 2433: Metabolic reprogramming by an epigenetic mechanism in endocrine therapy resistance of breast cancer Cancer Research. 74: 2433-2433. DOI: 10.1158/1538-7445.Am2014-2433 |
0.343 |
|
| 2013 |
Zhang Y, Yan W, Chen X. Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells. Plos One. 8: e85624. PMID 24386484 DOI: 10.1371/Journal.Pone.0085624 |
0.491 |
|
| 2013 |
Zhang M, Zhang J, Chen X, Cho SJ, Chen X. Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1. Genes & Development. 27: 2246-58. PMID 24142875 DOI: 10.1101/Gad.221739.113 |
0.472 |
|
| 2013 |
Cho SJ, Jung YS, Chen X. Poly (C)-binding protein 1 regulates p63 expression through mRNA stability. Plos One. 8: e71724. PMID 23940783 DOI: 10.1371/Journal.Pone.0071724 |
0.511 |
|
| 2013 |
Zhang J, Xu E, Chen X. Regulation of Mdm2 mRNA stability by RNA-binding protein RNPC1. Oncotarget. 4: 1121-2. PMID 23912475 DOI: 10.18632/Oncotarget.1185 |
0.544 |
|
| 2013 |
Berger C, Qian Y, Chen X. The p53-estrogen receptor loop in cancer. Current Molecular Medicine. 13: 1229-1240. PMID 23865427 DOI: 10.2174/15665240113139990065 |
0.636 |
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| 2013 |
Yin T, Cho SJ, Chen X. RNPC1, an RNA-binding protein and a p53 target, regulates macrophage inhibitory cytokine-1 (MIC-1) expression through mRNA stability. The Journal of Biological Chemistry. 288: 23680-6. PMID 23836903 DOI: 10.1074/Jbc.M113.480186 |
0.441 |
|
| 2013 |
Zhang Y, Yan W, Jung YS, Chen X. PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. Plos One. 8: e66464. PMID 23805223 DOI: 10.1371/Journal.Pone.0066464 |
0.541 |
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| 2013 |
Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proceedings of the National Academy of Sciences of the United States of America. 110: 9362-7. PMID 23690620 DOI: 10.1073/Pnas.1221242110 |
0.549 |
|
| 2013 |
Zhang Y, Yan W, Chen X. P63 regulates tubular formation via epithelial-to-mesenchymal transition. Oncogene. 33: 1548-57. PMID 23542170 DOI: 10.1038/Onc.2013.101 |
0.494 |
|
| 2013 |
Zhang J, Xu E, Chen X. TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function. The Journal of Biological Chemistry. 288: 7727-37. PMID 23362263 DOI: 10.1074/Jbc.M112.429522 |
0.418 |
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| 2013 |
Qian Y, Chen X. Senescence regulation by the p53 protein family. Methods in Molecular Biology (Clifton, N.J.). 965: 37-61. PMID 23296650 DOI: 10.1007/978-1-62703-239-1_3 |
0.701 |
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| 2013 |
Yan W, Chen X, Zhang Y, Zhang J, Jung YS, Chen X. Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein. The Journal of Biological Chemistry. 288: 2907-13. PMID 23271742 DOI: 10.1074/Jbc.M112.428607 |
0.368 |
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| 2013 |
Jung YS, Qian Y, Yan W, Chen X. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. The Journal of Investigative Dermatology. 133: 1178-87. PMID 23235527 DOI: 10.1038/Jid.2012.466 |
0.688 |
|
| 2012 |
Yan W, Zhang Y, Zhang J, Cho SJ, Chen X. HuR is necessary for mammary epithelial cell proliferation and polarity at least in part via ΔNp63. Plos One. 7: e45336. PMID 23028944 DOI: 10.1371/Journal.Pone.0045336 |
0.424 |
|
| 2012 |
Qian Y, Jung YS, Chen X. DEC1 and MIC-1: new players of p53-dependent cell fate decision. Cell Cycle (Georgetown, Tex.). 11: 3525-6. PMID 22935706 DOI: 10.4161/Cc.21962 |
0.717 |
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| 2012 |
Seo Kw, Holt R, Jung YS, Rodriguez CO, Chen X, Rebhun RB. Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines. Plos One. 7: e42960. PMID 22927942 DOI: 10.1371/Journal.Pone.0042960 |
0.346 |
|
| 2012 |
Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X. Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. The Journal of Biological Chemistry. 287: 34410-8. PMID 22908227 DOI: 10.1074/Jbc.M112.384990 |
0.46 |
|
| 2012 |
Berger CE, Qian Y, Liu G, Chen H, Chen X. p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells. The Journal of Biological Chemistry. 287: 30117-27. PMID 22787161 DOI: 10.1074/Jbc.M112.367326 |
0.631 |
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| 2012 |
Qian Y, Jung YS, Chen X. Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proceedings of the National Academy of Sciences of the United States of America. 109: 11300-5. PMID 22723347 DOI: 10.1073/Pnas.1203185109 |
0.691 |
|
| 2012 |
Hertwig F, Meyer K, Braun S, Ek S, Spang R, Pfenninger CV, Artner I, Prost G, Chen X, Biegel JA, Judkins AR, Englund E, Nuber UA. Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Research. 72: 3381-92. PMID 22719073 DOI: 10.1158/0008-5472.Can-11-3525 |
0.303 |
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| 2012 |
Xu E, Zhang J, Chen X. MDM2 expression is repressed by the RNA-binding protein RNPC1 via mRNA stability. Oncogene. 32: 2169-78. PMID 22710720 DOI: 10.1038/Onc.2012.238 |
0.441 |
|
| 2012 |
Jung YS, Qian Y, Chen X. Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. Febs Letters. 586: 1397-402. PMID 22673504 DOI: 10.1016/J.Febslet.2012.03.052 |
0.623 |
|
| 2012 |
Yang P, Guo L, Duan ZJ, Tepper CG, Xue L, Chen X, Kung HJ, Gao AC, Zou JX, Chen HW. Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop. Molecular and Cellular Biology. 32: 3121-31. PMID 22645312 DOI: 10.1128/Mcb.00204-12 |
0.367 |
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| 2012 |
Yan W, Zhang J, Zhang Y, Jung YS, Chen X. p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Molecular and Cellular Biology. 32: 2336-48. PMID 22508983 DOI: 10.1128/Mcb.00215-12 |
0.549 |
|
| 2012 |
Nadiminty N, Tummala R, Lou W, Zhu Y, Shi XB, Zou JX, Chen H, Zhang J, Chen X, Luo J, deVere White RW, Kung HJ, Evans CP, Gao AC. MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. Plos One. 7: e32832. PMID 22479342 DOI: 10.1371/Journal.Pone.0032832 |
0.313 |
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| 2012 |
Zhang Y, Yan W, Jung YS, Chen X. Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition. The Journal of Biological Chemistry. 287: 17746-53. PMID 22457351 DOI: 10.1074/Jbc.M112.358143 |
0.464 |
|
| 2012 |
Cho SJ, Jung YS, Zhang J, Chen X. The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation. The Journal of Biological Chemistry. 287: 14535-44. PMID 22371495 DOI: 10.1074/Jbc.M111.326827 |
0.351 |
|
| 2012 |
Jung YS, Qian Y, Chen X. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. Dna Repair. 11: 177-84. PMID 22056306 DOI: 10.1016/J.Dnarep.2011.10.017 |
0.627 |
|
| 2012 |
Berger C, Qian Y, Chen X. Abstract 1284: Estrogen receptor alpha transcriptionally regulates p53 in MCF7 human breast cancer cells Cancer Research. 72: 1284-1284. DOI: 10.1158/1538-7445.Am2012-1284 |
0.567 |
|
| 2012 |
Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X, Chen X. Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8 Oncogene. 32: 599-609. DOI: 10.1038/Onc.2012.81 |
0.487 |
|
| 2011 |
Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, ... ... Chen X, et al. Role of Pirh2 in mediating the regulation of p53 and c-Myc. Plos Genetics. 7: e1002360. PMID 22125490 DOI: 10.1371/Journal.Pgen.1002360 |
0.47 |
|
| 2011 |
Zhang J, Chen X. Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions. Cell Cycle (Georgetown, Tex.). 10: 3235. PMID 21946519 DOI: 10.4161/Cc.10.19.17128 |
0.544 |
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| 2011 |
Jung YS, Qian Y, Chen X. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. The Journal of Biological Chemistry. 286: 35388-95. PMID 21852228 DOI: 10.1074/Jbc.M111.261537 |
0.679 |
|
| 2011 |
Jung YS, Hakem A, Hakem R, Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Molecular and Cellular Biology. 31: 3997-4006. PMID 21791603 DOI: 10.1128/Mcb.05808-11 |
0.374 |
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| 2011 |
Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen H, Chen X. Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas. Genes & Development. 25: 1528-43. PMID 21764855 DOI: 10.1101/Gad.2069311 |
0.541 |
|
| 2011 |
Zhang Y, Yan W, Chen X. Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions. The Journal of Biological Chemistry. 286: 16218-28. PMID 21454711 DOI: 10.1074/Jbc.M110.214585 |
0.493 |
|
| 2011 |
Yan W, Zhang Y, Zhang J, Liu S, Cho SJ, Chen X. Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. The Journal of Biological Chemistry. 286: 17478-86. PMID 21454520 DOI: 10.1074/Jbc.M111.231639 |
0.492 |
|
| 2011 |
Qian Y, Jung YS, Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. The Journal of Biological Chemistry. 286: 12033-41. PMID 21317427 DOI: 10.1074/Jbc.M110.207241 |
0.589 |
|
| 2011 |
Scoumanne A, Cho SJ, Zhang J, Chen X. The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability. Nucleic Acids Research. 39: 213-24. PMID 20817677 DOI: 10.1093/Nar/Gkq778 |
0.538 |
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| 2010 |
Wang F, Fu X, Chen X, Chen X, Zhao Y. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. Plos One. 5: e13459. PMID 20976134 DOI: 10.1371/Journal.Pone.0013459 |
0.389 |
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| 2010 |
Zhang Y, Scoumanne A, Chen X. G Protein-Coupled Receptor 87: a Promising Opportunity for Cancer Drug Discovery. Molecular and Cellular Pharmacology. 2: 111-116. PMID 20686680 DOI: 10.4255/Mcpharmacol.10.15 |
0.464 |
|
| 2010 |
Cho SJ, Chen X. Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners. The Journal of Biological Chemistry. 285: 27159-66. PMID 20576604 DOI: 10.1074/Jbc.M110.142117 |
0.504 |
|
| 2010 |
Xu Y, Yan W, Chen X. SNF5, a core component of the SWI/SNF complex, is necessary for p53 expression and cell survival, in part through eIF4E. Oncogene. 29: 4090-100. PMID 20473326 DOI: 10.1038/Onc.2010.159 |
0.551 |
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| 2010 |
Zhang J, Jun Cho S, Chen X. RNPC1, an RNA-binding protein and a target of the p53 family, regulates p63 expression through mRNA stability. Proceedings of the National Academy of Sciences of the United States of America. 107: 9614-9. PMID 20457941 DOI: 10.1073/Pnas.0912594107 |
0.533 |
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| 2010 |
Yan W, Chen X. Characterization of functional domains necessary for mutant p53 gain of function. The Journal of Biological Chemistry. 285: 14229-38. PMID 20212049 DOI: 10.1074/Jbc.M109.097253 |
0.458 |
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| 2010 |
Qian Y, Chen X. Tumor suppression by p53: making cells senescent. Histology and Histopathology. 25: 515-26. PMID 20183804 DOI: 10.14670/Hh-25.515 |
0.699 |
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| 2010 |
Jung YS, Qian Y, Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cellular Signalling. 22: 1003-12. PMID 20100570 DOI: 10.1016/J.Cellsig.2010.01.013 |
0.691 |
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| 2010 |
Cho SJ, Zhang J, Chen X. RNPC1 modulates the RNA-binding activity of, and cooperates with, HuR to regulate p21 mRNA stability. Nucleic Acids Research. 38: 2256-67. PMID 20064878 DOI: 10.1093/Nar/Gkp1229 |
0.476 |
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| 2010 |
Jung YS, Liu G, Chen X. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Molecular and Cellular Biology. 30: 1041-8. PMID 20008555 DOI: 10.1128/Mcb.01198-09 |
0.433 |
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| 2010 |
Scoumanne A, Cho SJ, Chen X. Abstract 3151: Posttranscriptional regulation of p21 by MCG10, an RNA-binding protein and a target of tumor suppressor p53 Cancer Research. 70: 3151-3151. DOI: 10.1158/1538-7445.Am10-3151 |
0.543 |
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| 2009 |
Zhang Y, Qian Y, Lu W, Chen X. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Research. 69: 6049-56. PMID 19602589 DOI: 10.1158/0008-5472.Can-09-0621 |
0.689 |
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| 2009 |
Scoumanne A, Zhang J, Chen X. PRMT5 is required for cell-cycle progression and p53 tumor suppressor function Nucleic Acids Research. 37: 4965-4976. PMID 19528079 DOI: 10.1093/Nar/Gkp516 |
0.563 |
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| 2009 |
Yan W, Chen X. Identification of GRO1 as a critical determinant for mutant p53 gain of function. The Journal of Biological Chemistry. 284: 12178-87. PMID 19258312 DOI: 10.1074/Jbc.M900994200 |
0.517 |
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| 2009 |
Zhang J, Chen X, Kent MS, Rodriguez CO, Chen X. Establishment of a dog model for the p53 family pathway and identification of a novel isoform of p21 cyclin-dependent kinase inhibitor. Molecular Cancer Research : McR. 7: 67-78. PMID 19147538 DOI: 10.1158/1541-7786.Mcr-08-0347 |
0.54 |
|
| 2008 |
Zhang J, Chen X. Posttranscriptional regulation of p53 and its targets by RNA-binding proteins. Current Molecular Medicine. 8: 845-9. PMID 19075680 DOI: 10.2174/156652408786733748 |
0.521 |
|
| 2008 |
Zhang Y, Shu L, Chen X. Syntaxin 6, a regulator of the protein trafficking machinery and a target of the p53 family, is required for cell adhesion and survival. The Journal of Biological Chemistry. 283: 30689-98. PMID 18779328 DOI: 10.1074/Jbc.M801711200 |
0.527 |
|
| 2008 |
Yan W, Liu G, Scoumanne A, Chen X. Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. Cancer Research. 68: 6789-96. PMID 18701504 DOI: 10.1158/0008-5472.Can-08-0810 |
0.527 |
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| 2008 |
Scoumanne A, Chen X. Protein methylation: a new mechanism of p53 tumor suppressor regulation. Histology and Histopathology. 23: 1143-1149. PMID 18581285 DOI: 10.14670/Hh-23.1143 |
0.521 |
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| 2008 |
Qian Y, Chen X. ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. The Journal of Biological Chemistry. 283: 22410-6. PMID 18556654 DOI: 10.1074/Jbc.M800643200 |
0.697 |
|
| 2008 |
Helton ES, Zhang J, Chen X. The proline-rich domain in p63 is necessary for the transcriptional and apoptosis-inducing activities of TAp63. Oncogene. 27: 2843-50. PMID 18037962 DOI: 10.1038/Sj.Onc.1210948 |
0.803 |
|
| 2008 |
Qian Y, Zhang J, Yan B, Chen X. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. The Journal of Biological Chemistry. 283: 2896-905. PMID 18025081 DOI: 10.1074/Jbc.M708624200 |
0.707 |
|
| 2007 |
Xu Y, Zhang J, Chen X. The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. The Journal of Biological Chemistry. 282: 37429-35. PMID 17938176 DOI: 10.1074/Jbc.M706039200 |
0.558 |
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| 2007 |
Yan W, Chen X. Targeted repression of bone morphogenetic protein 7, a novel target of the p53 family, triggers proliferative defect in p53-deficient breast cancer cells. Cancer Research. 67: 9117-24. PMID 17909016 DOI: 10.1158/0008-5472.Can-07-0996 |
0.556 |
|
| 2007 |
Zhang J, Chen X. The p53 family: prospect for cancer gene therapy. Cancer Biology & Therapy. 6: 116-8. PMID 17612008 DOI: 10.4161/Cbt.6.1.3790 |
0.398 |
|
| 2007 |
Song L, Yan W, Chen X, Deng CX, Wang Q, Jiao K. Myocardial smad4 is essential for cardiogenesis in mouse embryos. Circulation Research. 101: 277-85. PMID 17585069 DOI: 10.1161/Circresaha.107.155630 |
0.306 |
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| 2007 |
Harms KL, Chen X. Histone deacetylase 2 modulates p53 transcriptional activities through regulation of p53-DNA binding activity. Cancer Research. 67: 3145-52. PMID 17409421 DOI: 10.1158/0008-5472.Can-06-4397 |
0.775 |
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| 2007 |
Scoumanne A, Chen X. The lysine-specific demethylase 1 is required for cell proliferation in both p53-dependent and -independent manners. The Journal of Biological Chemistry. 282: 15471-5. PMID 17409384 DOI: 10.1074/Jbc.M701023200 |
0.535 |
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| 2007 |
Geng Y, Akhtar RS, Shacka JJ, Klocke BJ, Zhang J, Chen X, Roth KA. p53 transcription-dependent and -independent regulation of cerebellar neural precursor cell apoptosis. Journal of Neuropathology and Experimental Neurology. 66: 66-74. PMID 17204938 DOI: 10.1097/Nen.0B013E31802D4Ab4 |
0.477 |
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| 2007 |
Helton ES, Chen X. p53 modulation of the DNA damage response. Journal of Cellular Biochemistry. 100: 883-96. PMID 17031865 DOI: 10.1002/Jcb.21091 |
0.78 |
|
| 2006 |
Shu L, Yan W, Chen X. RNPC1, an RNA-binding protein and a target of the p53 family, is required for maintaining the stability of the basal and stress-induced p21 transcript. Genes & Development. 20: 2961-72. PMID 17050675 DOI: 10.1101/Gad.1463306 |
0.536 |
|
| 2006 |
Xu Y, Chen X. Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family. The Journal of Biological Chemistry. 281: 26702-13. PMID 16831876 DOI: 10.1074/Jbc.M604758200 |
0.549 |
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| 2006 |
Scoumanne A, Chen X. The epithelial cell transforming sequence 2, a guanine nucleotide exchange factor for Rho GTPases, is repressed by p53 via protein methyltransferases and is required for G1-S transition. Cancer Research. 66: 6271-9. PMID 16778203 DOI: 10.1158/0008-5472.Can-06-0121 |
0.569 |
|
| 2006 |
Harms KL, Chen X. p19ras brings a new twist to the regulation of p73 by Mdm2. Science's Stke : Signal Transduction Knowledge Environment. 2006: pe24. PMID 16738062 DOI: 10.1126/Stke.3372006Pe24 |
0.777 |
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| 2006 |
Zhang J, Yan W, Chen X. p53 is required for nerve growth factor-mediated differentiation of PC12 cells via regulation of TrkA levels. Cell Death and Differentiation. 13: 2118-28. PMID 16729028 DOI: 10.1038/Sj.Cdd.4401972 |
0.486 |
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| 2006 |
Harms KL, Chen X. The functional domains in p53 family proteins exhibit both common and distinct properties. Cell Death and Differentiation. 13: 890-7. PMID 16543939 DOI: 10.1038/Sj.Cdd.4401904 |
0.712 |
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| 2006 |
Jung EJ, Liu G, Zhou W, Chen X. Myosin VI is a mediator of the p53-dependent cell survival pathway. Molecular and Cellular Biology. 26: 2175-86. PMID 16507995 DOI: 10.1128/Mcb.26.6.2175-2186.2006 |
0.49 |
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| 2006 |
Liu G, Chen X. DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Molecular and Cellular Biology. 26: 1398-413. PMID 16449651 DOI: 10.1128/Mcb.26.4.1398-1413.2006 |
0.479 |
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| 2006 |
Yan W, Chen X. GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. The Journal of Biological Chemistry. 281: 7856-62. PMID 16446369 DOI: 10.1074/Jbc.M512655200 |
0.536 |
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| 2006 |
Helton ES, Zhu J, Chen X. The unique NH2-terminally deleted (DeltaN) residues, the PXXP motif, and the PPXY motif are required for the transcriptional activity of the DeltaN variant of p63. The Journal of Biological Chemistry. 281: 2533-42. PMID 16319057 DOI: 10.1074/Jbc.M507964200 |
0.796 |
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| 2006 |
Liu G, Chen X. Regulation of the p53 transcriptional activity. Journal of Cellular Biochemistry. 97: 448-58. PMID 16288459 DOI: 10.1002/Jcb.20700 |
0.484 |
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| 2006 |
Tsai MH, Chen X, Chandramouli GV, Chen Y, Yan H, Zhao S, Keng P, Liber HL, Coleman CN, Mitchell JB, Chuang EY. Transcriptional responses to ionizing radiation reveal that p53R2 protects against radiation-induced mutagenesis in human lymphoblastoid cells. Oncogene. 25: 622-32. PMID 16247478 DOI: 10.1038/Sj.Onc.1209082 |
0.45 |
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| 2006 |
Liu G, Chen X. Erratum: DNA polymerase η, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation (Molecular and Cellular Biology (2006) 26,4(1398-1413)) Molecular and Cellular Biology. 26. DOI: 10.1128/Mcb.26.9.3680.2006 |
0.426 |
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| 2005 |
Scoumanne A, Harms KL, Chen X. Structural basis for gene activation by p53 family members. Cancer Biology & Therapy. 4: 1178-85. PMID 16294021 DOI: 10.4161/Cbt.4.11.2254 |
0.766 |
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| 2005 |
Li M, Zhang Z, Hill DL, Chen X, Wang H, Zhang R. Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Research. 65: 8200-8. PMID 16166295 DOI: 10.1158/0008-5472.Can-05-1302 |
0.441 |
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| 2005 |
Liu G, Chen X. The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. The Journal of Biological Chemistry. 280: 20111-9. PMID 15769743 DOI: 10.1074/Jbc.M413889200 |
0.438 |
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| 2005 |
Harms KL, Chen X. The C terminus of p53 family proteins is a cell fate determinant. Molecular and Cellular Biology. 25: 2014-30. PMID 15713654 DOI: 10.1128/Mcb.25.5.2014-2030.2005 |
0.781 |
|
| 2004 |
Harms K, Nozell S, Chen X. The common and distinct target genes of the p53 family transcription factors Cellular and Molecular Life Sciences. 61: 822-842. PMID 15095006 DOI: 10.1007/S00018-003-3304-4 |
0.777 |
|
| 2004 |
Zhang Z, Wang H, Li M, Agrawal S, Chen X, Zhang R. MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53. The Journal of Biological Chemistry. 279: 16000-6. PMID 14761977 DOI: 10.1074/Jbc.M312264200 |
0.541 |
|
| 2004 |
Willis A, Jung EJ, Wakefield T, Chen X. Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes. Oncogene. 23: 2330-8. PMID 14743206 DOI: 10.1038/Sj.Onc.1207396 |
0.517 |
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| 2004 |
Liu G, Nozell S, Xiao H, Chen X. DeltaNp73beta is active in transactivation and growth suppression. Molecular and Cellular Biology. 24: 487-501. PMID 14701724 DOI: 10.1128/Mcb.24.2.487-501.2004 |
0.532 |
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| 2003 |
Watcharasit P, Bijur GN, Song L, Zhu J, Chen X, Jope RS. Glycogen synthase kinase-3beta (GSK3beta) binds to and promotes the actions of p53. The Journal of Biological Chemistry. 278: 48872-9. PMID 14523002 DOI: 10.1074/Jbc.M305870200 |
0.505 |
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| 2003 |
Willis AC, Pipes T, Zhu J, Chen X. p73 can suppress the proliferation of cells that express mutant p53. Oncogene. 22: 5481-95. PMID 12934108 DOI: 10.1038/Sj.Onc.1206505 |
0.539 |
|
| 2003 |
Nozell S, Wu Y, McNaughton K, Liu G, Willis A, Paik JC, Chen X. Characterization of p73 functional domains necessary for transactivation and growth suppression. Oncogene. 22: 4333-47. PMID 12853970 DOI: 10.1038/Sj.Onc.1206470 |
0.457 |
|
| 2003 |
Dohn M, Nozell S, Willis A, Chen X. Tumor suppressor gene-inducible cell lines. Methods in Molecular Biology (Clifton, N.J.). 223: 221-35. PMID 12777734 DOI: 10.1385/1-59259-329-1:221 |
0.317 |
|
| 2003 |
Chen X, Liu G, Zhu J, Jiang J, Nozell S, Willis A. Isolation and characterization of fourteen novel putative and nine known target genes of the p53 family. Cancer Biology & Therapy. 2: 55-62. PMID 12673118 DOI: 10.4161/Cbt.180 |
0.538 |
|
| 2003 |
Liu G, Xia T, Chen X. The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. The Journal of Biological Chemistry. 278: 17557-65. PMID 12609999 DOI: 10.1074/Jbc.M210696200 |
0.508 |
|
| 2002 |
Woessmann W, Chen X, Borkhardt A. Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemotherapy and Pharmacology. 50: 397-404. PMID 12439598 DOI: 10.1007/S00280-002-0502-Y |
0.439 |
|
| 2002 |
Liu G, Chen X. The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis. Oncogene. 21: 7195-204. PMID 12370809 DOI: 10.1038/Sj.Onc.1205862 |
0.555 |
|
| 2002 |
Willis AC, Chen X. The promise and obstacle of p53 as a cancer therapeutic agent. Current Molecular Medicine. 2: 329-45. PMID 12108946 DOI: 10.2174/1566524023362474 |
0.525 |
|
| 2002 |
Watcharasit P, Bijur GN, Zmijewski JW, Song L, Zmijewska A, Chen X, Johnson GV, Jope RS. Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 99: 7951-5. PMID 12048243 DOI: 10.1073/Pnas.122062299 |
0.477 |
|
| 2002 |
Chen X. Cyclin G: a regulator of the p53-Mdm2 network. Developmental Cell. 2: 518-9. PMID 12015958 DOI: 10.1016/S1534-5807(02)00182-X |
0.424 |
|
| 2002 |
Ma P, Magut M, Chen X, Chen CY. P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity. Molecular and Cellular Biology. 22: 2928-38. PMID 11940651 DOI: 10.1128/Mcb.22.9.2928-2938.2002 |
0.422 |
|
| 2002 |
Nozell S, Chen X. p21B, a variant of p21(Waf1/Cip1), is induced by the p53 family. Oncogene. 21: 1285-94. PMID 11850848 DOI: 10.1038/Sj.Onc.1205191 |
0.543 |
|
| 2002 |
Baptiste N, Friedlander P, Chen X, Prives C. The proline-rich domain of p53 is required for cooperation with anti-neoplastic agents to promote apoptosis of tumor cells. Oncogene. 21: 9-21. PMID 11791172 DOI: 10.1038/Sj.Onc.1205015 |
0.515 |
|
| 2001 |
Dohn M, Jiang J, Chen X. Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis. Oncogene. 20: 6503-15. PMID 11641774 DOI: 10.1038/Sj.Onc.1204816 |
0.566 |
|
| 2001 |
Zhu J, Nozell S, Wang J, Jiang J, Zhou W, Chen X. p73 cooperates with DNA damage agents to induce apoptosis in MCF7 cells in a p53-dependent manner. Oncogene. 20: 4050-7. PMID 11494133 DOI: 10.1038/Sj.Onc.1204516 |
0.54 |
|
| 2001 |
Dohn M, Zhang S, Chen X. p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes. Oncogene. 20: 3193-205. PMID 11423969 DOI: 10.1038/Sj.Onc.1204427 |
0.566 |
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| 2001 |
Chen X, Zheng Y, Zhu J, Jiang J, Wang J. p73 is transcriptionally regulated by DNA damage, p53, and p73. Oncogene. 20: 769-74. PMID 11314010 DOI: 10.1038/Sj.Onc.1204149 |
0.534 |
|
| 2001 |
Zheng X, Chen X. Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. Febs Letters. 489: 4-7. PMID 11231003 DOI: 10.1016/S0014-5793(00)02437-6 |
0.511 |
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| 2000 |
Zhu J, Zhang S, Jiang J, Chen X. Definition of the p53 Functional Domains Necessary for Inducing Apoptosis Journal of Biological Chemistry. 275: 39927-39934. PMID 10982799 DOI: 10.1074/Jbc.M005676200 |
0.359 |
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| 2000 |
Zhu J, Chen X. MCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M Molecular and Cellular Biology. 20: 5602-5618. PMID 10891498 DOI: 10.1128/Mcb.20.15.5602-5618.2000 |
0.519 |
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| 2000 |
Wang J, Shou J, Chen X. Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53. Oncogene. 19: 1843-8. PMID 10777218 DOI: 10.1038/Sj.Onc.1203503 |
0.537 |
|
| 2000 |
Zhu K, Wang J, Zhu J, Jiang J, Shou J, Chen X. p53 induces TAP1 and enhances the transport of MHC class I peptides. Oncogene. 18: 7740-7. PMID 10618714 DOI: 10.1038/Sj.Onc.1203235 |
0.464 |
|
| 1999 |
Chen X. The p53 family: same response, different signals? Molecular Medicine Today. 5: 387-392. PMID 10462750 DOI: 10.1016/S1357-4310(99)01545-2 |
0.552 |
|
| 1998 |
Zhu J, Zhou W, Jiang J, Chen X. Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis Journal of Biological Chemistry. 273: 13030-13036. PMID 9582339 DOI: 10.1074/Jbc.273.21.13030 |
0.499 |
|
| 1998 |
Niculescu AB, Chen X, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Molecular and Cellular Biology. 18: 629-43. PMID 9418909 DOI: 10.1128/Mcb.18.1.629 |
0.481 |
|
| 1997 |
Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ. p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner. Molecular and Cellular Biology. 17: 7220-9. PMID 9372954 DOI: 10.1128/Mcb.17.12.7220 |
0.479 |
|
| 1996 |
Chen X, Ko LJ, Jayaraman L, Prives C. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes & Development. 10: 2438-51. PMID 8843196 DOI: 10.1101/Gad.10.19.2438 |
0.551 |
|
| 1993 |
Friedman PN, Chen X, Bargonetti J, Prives C. The p53 protein is an unusually shaped tetramer that binds directly to DNA Proceedings of the National Academy of Sciences of the United States of America. 90: 3319-3323. PMID 8475074 DOI: 10.1073/Pnas.90.8.3319 |
0.448 |
|
| 1993 |
Chen X, Farmer G, Zhu H, Prywes R, Prives C. Cooperative DNA binding of p53 with TFIID (TBP): a possible mechanism for transcriptional activation. Genes & Development. 7: 1837-49. PMID 8405994 DOI: 10.1101/Gad.7.10.1837 |
0.477 |
|
| 1993 |
Bargonetti J, Manfredi JJ, Chen X, Marshak DR, Prives C. A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein Genes and Development. 7: 2565-2574. PMID 8276239 DOI: 10.1101/Gad.7.12B.2565 |
0.413 |
|
| 1992 |
Chen X, Sondermeijer PJA, Velicer LF. Identification of a unique Marek's disease virus gene which encodes a 38-kilodalton phosphoprotein and is expressed in both lytically infected cells and latently infected lymphoblastoid tumor cells. Journal of Virology. 66: 85-94. PMID 1309266 DOI: 10.1128/Jvi.66.1.85-94.1992 |
0.334 |
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