Daniel C. Link - Publications

Affiliations: 
Biology & Biomedical Sciences (Molecular Cell Biology) Washington University, Saint Louis, St. Louis, MO 
Area:
Molecular Biology

268 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Nonavinkere Srivatsan S, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, ... ... Link DC, et al. Genomic landscape of TP53-mutated myeloid malignancies. Blood Advances. PMID 37339484 DOI: 10.1182/bloodadvances.2023010156  0.632
2023 Abel HJ, Oetjen KA, Miller CA, Ramakrishnan SM, Day RB, Helton NM, Fronick CC, Fulton RS, Heath SE, Tarnawsky SP, Srivatsan SN, Duncavage EJ, Schroeder MC, Payton JE, Spencer DH, ... ... Link DC, et al. Genomic landscape of -mutated myeloid malignancies. Medrxiv : the Preprint Server For Health Sciences. PMID 36711871 DOI: 10.1101/2023.01.10.23284322  0.622
2022 Kramer MH, Zhang Q, Sprung R, Day RB, Erdmann-Gilmore P, Li Y, Xu Z, Helton NM, George DR, Mi Y, Westervelt P, Payton JE, Ramakrishnan SM, Miller CA, Link DC, et al. Proteomic and Phosphoproteomic Landscapes of Acute Myeloid Leukemia. Blood. PMID 35895896 DOI: 10.1182/blood.2022016033  0.64
2022 Menssen AJ, Khanna A, Miller CA, Nonavinkere Srivatsan S, Chang GS, Shao J, Robinson J, O'Laughlin M, Fronick CC, Fulton RS, Brendel K, Heath SE, Saba R, Welch JS, Spencer DH, ... ... Link DC, et al. Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression. Blood Cancer Discovery. OF1-OF16. PMID 35709710 DOI: 10.1158/2643-3230.BCD-21-0155  0.637
2022 Li S, Yao JC, Oetjen KA, Krambs JR, Xia J, Zhang J, Schmidt AP, Helton NM, Fulton RS, Heath SE, Turnbull IR, Mbalaviele G, Ley TJ, Walter MJ, Link DC. IL-1b expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function. Blood. PMID 35675516 DOI: 10.1182/blood.2022016084  0.81
2022 Yao JC, Oetjen KA, Wang T, Xu H, Abou-Ezzi G, Krambs JR, Uttarwar S, Duncavage EJ, Link DC. TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche. The Journal of Clinical Investigation. PMID 35439167 DOI: 10.1172/JCI154092  0.81
2022 Upadhyay P, Beales J, Shah NM, Gruszczynska A, Miller CA, Petti AA, Ramakrishnan SM, Link DC, Ley TJ, Welch JS. Recurrent Transcriptional Responses in AML and MDS patients Treated with Decitabine. Experimental Hematology. PMID 35429619 DOI: 10.1016/j.exphem.2022.04.002  0.626
2022 Ferraro F, Gruszczynska A, Ruzinova MB, Miller CA, Percival ME, Uy GL, Pusic I, Jacoby MA, Christopher MJ, Kim MY, Westervelt P, Cashen AF, Schroeder MA, DiPersio JF, Abboud CN, ... ... Link DC, et al. Decitabine salvage for Tumor Protein P53mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy. Haematologica. PMID 35236053 DOI: 10.3324/haematol.2021.280153  0.568
2022 Petti AA, Khan SM, Xu Z, Helton N, Fronick CC, Fulton R, Ramakrishnan SM, Nonavinkere Srivatsan S, Heath SE, Westervelt P, Payton JE, Walter MJ, Link DC, DiPersio J, Miller C, et al. Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia. Blood Cancer Discovery. 3: 32-49. PMID 35019859 DOI: 10.1158/2643-3230.BCD-21-0050  0.644
2021 Wilson ER, Helton NM, Heath SE, Fulton RS, Payton JE, Welch JS, Walter MJ, Westervelt P, DiPersio JF, Link DC, Miller CA, Ley TJ, Spencer DH. Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells. Leukemia. PMID 34873300 DOI: 10.1038/s41375-021-01476-y  0.627
2021 Ferraro F, Miller CA, Christensen KA, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Kohlschmidt J, Eisfeld AK, Bloomfield CD, Ramakrishnan SM, Day RB, Wartman LD, Uy GL, Welch JS, ... ... Link DC, et al. Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34845035 DOI: 10.1073/pnas.2116427118  0.819
2021 Glaser DE, Curtis MB, Sariano PA, Rollins ZA, Shergill BS, Anand A, Deely AM, Shirure VS, Anderson L, Lowen JM, Ng NR, Weilbaecher K, Link DC, George SC. Organ-on-a-chip model of vascularized human bone marrow niches. Biomaterials. 121245. PMID 34810038 DOI: 10.1016/j.biomaterials.2021.121245  0.303
2021 Krambs JR, Monlish DA, Gao F, Schuettpelz LG, Link DC. Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice. Frontiers in Immunology. 12: 767267. PMID 34737755 DOI: 10.3389/fimmu.2021.767267  0.787
2021 Duncavage EJ, Schroeder MC, O'Laughlin M, Wilson R, MacMillan S, Bohannon A, Kruchowski S, Garza J, Du F, Hughes AEO, Robinson J, Hughes E, Heath SE, Baty JD, Neidich J, ... ... Link DC, et al. Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers. The New England Journal of Medicine. 384: 924-935. PMID 33704937 DOI: 10.1056/NEJMoa2024534  0.785
2020 Shannon K, Link DC. Soil and Seed: Coconspirators in Therapy-Induced Myeloid Neoplasms. Blood Cancer Discovery. 1: 10-12. PMID 34661135 DOI: 10.1158/2643-3249.BCD-20-0080  0.312
2020 Ritter M, Klimiankou M, Klimenkova O, Schambach A, Hoffmann D, Schmidt A, Kanz L, Link DC, Welte K, Skokowa J. Cooperating, congenital neutropenia-associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs. Annals of Hematology. 99: 2329-2338. PMID 32821971 DOI: 10.1007/S00277-020-04194-0  0.486
2020 Xiao J, Wang C, Yao JC, Alippe Y, Yang T, Kress D, Sun K, Kostecki KL, Monahan JB, Veis DJ, Abu-Amer Y, Link DC, Mbalaviele G. Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells. Plos Biology. 18: e3000807. PMID 32760056 DOI: 10.1371/Journal.Pbio.3000807  0.334
2020 Warren JT, Link DC. Clonal hematopoiesis and risk for hematologic malignancy. Blood. PMID 32736382 DOI: 10.1182/Blood.2019000991  0.362
2020 Chen S, Wang Q, Yu H, Capitano ML, Vemula S, Nabinger SC, Gao R, Yao C, Kobayashi M, Geng Z, Fahey A, Henley D, Liu SZ, Barajas S, Cai W, ... ... Link DC, et al. Author Correction: Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway. Nature Communications. 11: 3856. PMID 32724180 DOI: 10.1038/S41467-020-17555-0  0.641
2020 Kapoor V, Collins A, Griffith K, Ghosh S, Wong N, Wang X, Challen GA, Krambs J, Link D, Hallahan DE, Thotala D. Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow. Oncotarget. 11: 1681-1690. PMID 32477458 DOI: 10.18632/Oncotarget.27564  0.825
2020 Krambs JR, Abou Ezzi G, Yao JC, Link DC. Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions. Plos One. 15: e0233751. PMID 32470079 DOI: 10.1371/Journal.Pone.0233751  0.814
2020 Matsushita Y, Nagata M, Kozloff KM, Welch JD, Mizuhashi K, Tokavanich N, Hallett SA, Link DC, Nagasawa T, Ono W, Ono N. A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration. Nature Communications. 11: 332. PMID 31949165 DOI: 10.1038/S41467-019-14029-W  0.449
2019 Chen S, Wang Q, Yu H, Capitano ML, Vemula S, Nabinger SC, Gao R, Yao C, Kobayashi M, Geng Z, Fahey A, Henley D, Liu SZ, Barajas S, Cai W, ... ... Link DC, et al. Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway. Nature Communications. 10: 5649. PMID 31827082 DOI: 10.1038/S41467-019-13542-2  0.697
2019 Berrien-Elliott MM, Sun Y, Neal C, Ireland A, Trissal MC, Sullivan RP, Wagner JA, Leong JW, Wong P, Mah-Som AY, Wong TN, Schappe T, Keppel CR, Cortez VS, Stamatiades EG, ... ... Link DC, et al. MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells. Immunity. PMID 31402259 DOI: 10.1016/J.Immuni.2019.06.016  0.665
2019 Abou-Ezzi G, Supakorndej T, Zhang J, Anthony B, Krambs J, Celik H, Karpova D, Craft CS, Link DC. TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow. Stem Cell Reports. PMID 31204302 DOI: 10.1016/J.Stemcr.2019.05.017  0.812
2019 Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, ... ... Link DC, et al. Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells. The Journal of Clinical Investigation. 130. PMID 31085833 DOI: 10.1172/Jci124738  0.388
2019 Zhang J, Supakorndej T, Krambs JR, Rao M, Abou-Ezzi G, Ye RY, Li S, Trinkaus K, Link DC. Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. The Journal of Clinical Investigation. 130. PMID 31039135 DOI: 10.1172/Jci124829  0.823
2019 Warren JT, Wattanasirakul P, Spencer DH, Locke A, Makaryan V, Bolyard AA, Welte K, Skokowa J, Dale DC, Link DC. Heterozygous Mutations of Clpb As a Newly Identified and Frequent Cause of Severe Congenital Neutropenia Blood. 134: 433-433. DOI: 10.1182/Blood-2019-129635  0.418
2019 Yao J, Abou Ezzi G, Krambs JR, Uttarwar S, Duncavage EJ, Link DC. TGF-β Signaling Contributes to Myelofibrosis and Clonal Dominance of Myeloproliferative Neoplasms Blood. 134: 470-470. DOI: 10.1182/Blood-2019-128943  0.815
2019 Xia J, Sun S, Jotte MR, Uy GL, Bohana-Kashtan O, Sorani E, Vainstein A, Peled A, Link DC. CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death Blood. 134: 2745-2745. DOI: 10.1182/Blood-2019-128881  0.374
2019 Oetjen KA, Bender DE, Ruzinova MB, Oh ST, Link DC. Interrogating the Spatial Architecture of Human Bone Marrow Via Imaging Mass Cytometry Blood. 134: 3728-3728. DOI: 10.1182/Blood-2019-127460  0.401
2019 Uy GL, Kadia TM, Stock W, Brammer JE, Bohana-Kashtan O, Vainstein A, Sorani E, Chen H, DiPersio JF, Link DC. CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma Blood. 134: 2630-2630. DOI: 10.1182/Blood-2019-127121  0.316
2019 Dale DC, Shannon JA, Bolyard AA, Connelly J, Link DC, Bonilla MA, Newburger PE. Severe Chronic Neutropenia in the Large Granular Lymphocyte Syndrome: Outcomes in Response to Granulocyte Colony Stimulating Factor (G-CSF) and Immunosuppressive Therapies Blood. 134: 3589-3589. DOI: 10.1182/Blood-2019-126181  0.393
2018 Christopher MJ, Petti AA, Rettig MP, Miller CA, Chendamarai E, Duncavage EJ, Klco JM, Helton NM, O'Laughlin M, Fronick CC, Fulton RS, Wilson RK, Wartman LD, Welch JS, Heath SE, ... ... Link DC, et al. Immune Escape of Relapsed AML Cells after Allogeneic Transplantation. The New England Journal of Medicine. PMID 30380364 DOI: 10.1056/Nejmoa1808777  0.79
2018 Duncavage EJ, Jacoby MA, Chang GS, Miller CA, Edwin N, Shao J, Elliott K, Robinson J, Abel H, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Brendel K, Saba R, ... ... Link DC, et al. Mutation Clearance after Transplantation for Myelodysplastic Syndrome. The New England Journal of Medicine. 379: 1028-1041. PMID 30207916 DOI: 10.1056/Nejmoa1804714  0.813
2018 Trissal MC, Wong TN, Yao JC, Ramaswamy R, Kuo I, Baty JD, Sun Y, Jih G, Parikh N, Berrien-Elliott MM, Fehniger TA, Ley TJ, Maillard I, Reddy P, Link DC. MIR142 loss-of-function mutations derepress ASH1L to increase HOXA gene expression and promote leukemogenesis. Cancer Research. PMID 29724719 DOI: 10.1158/0008-5472.Can-17-3592  0.767
2018 Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Robinson J, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Pusic I, Welch JS, Link DC, DiPersio JF, et al. Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant. Jci Insight. 3. PMID 29515031 DOI: 10.1172/Jci.Insight.98962  0.757
2018 Wong TN, Miller CA, Jotte MRM, Bagegni N, Baty JD, Schmidt AP, Cashen AF, Duncavage EJ, Helton NM, Fiala M, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, ... ... Link DC, et al. Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential. Nature Communications. 9: 455. PMID 29386642 DOI: 10.1038/S41467-018-02858-0  0.807
2018 Warner WA, Spencer DH, Trissal M, White BS, Helton N, Ley TJ, Link DC. Expression profiling of snoRNAs in normal hematopoiesis and AML. Blood Advances. 2: 151-163. PMID 29365324 DOI: 10.1182/Bloodadvances.2017006668  0.655
2018 Ritter MU, Klimenkova O, Klimiankou M, Schmidt AE, Stocking C, Kanz L, Zeidler C, Link DC, Welte K, Skokowa J. Understanding the Role of CSF3R and Runx1 Runt Homology Domain Missense Mutations in Leukemic Transformation of Hematopoietic Stem Cells Blood. 132: 1101-1101. DOI: 10.1182/Blood-2018-99-118644  0.49
2018 Abou Ezzi G, Supakorndej T, Zhang J, Krambs JR, Celik H, Link DC. TGF-β Signaling in Fetal Mesenchymal Progenitor Cells Plays an Essential Role in the Emergence of Bone Marrow Hematopoietic Niches Blood. 132: 3847-3847. DOI: 10.1182/Blood-2018-99-117396  0.823
2018 Xia J, Jotte MR, Sun S, Uy GL, Vainstein A, Sorani E, Bohana-Kashtan O, Shaw S, Link DC. The CXCR4 Antagonist, BL8040, Is Highly Active Against Human T-ALL in Preclinical Models Blood. 132: 2700-2700. DOI: 10.1182/Blood-2018-99-117213  0.361
2018 Jacoby M, Bera R, Fletcher T, Fiala MA, Trinkaus K, DiPersio JF, Stockerl-Goldstein KE, Schroeder MA, Link DC, Vij R. A Study of Tbo-Filgrastim (Granix) to Disrupt the Bone Marrow Microenvironment in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation Blood. 132: 2146-2146. DOI: 10.1182/Blood-2018-99-115603  0.359
2018 Yao J, Abou Ezzi G, Krambs JR, Duncavage EJ, Link DC. TGF-Beta Signaling in Mesenchymal Stromal Cells Contributes to Myelofibrosis but Not Hematopoietic Phenotypes in Myeloproliferative Neoplasms Blood. 132: 3053-3053. DOI: 10.1182/Blood-2018-99-113745  0.823
2018 Dale DC, Bolyard AA, Alter BP, Bonilla MA, Connelly J, Link DC, Newburger PE, Rosenberg PS, Shimamura A, Walkovich KJ. Myelodysplasia, Leukemia, Lymphoid Malignancies, and Other Cancers in Patients with Severe Chronic Neutropenia Blood. 132: 16-16. DOI: 10.1182/Blood-2018-99-112694  0.347
2017 Xia J, Miller CA, Baty J, Ramesh A, Jotte MRM, Fulton RS, Vogel TP, Cooper MA, Walkovich KJ, Makaryan V, Bolyard AA, Dinauer MC, Wilson DB, Vlachos A, Myers KC, ... ... Link DC, et al. Somatic mutations and clonal hematopoiesis in congenital neutropenia. Blood. PMID 29092827 DOI: 10.1182/Blood-2017-08-801985  0.4
2017 Zhang J, Griffith M, Miller CA, Griffith OL, Spencer DH, Walker JR, Magrini V, McGrath SD, Ly A, Helton NM, Trissal M, Link DC, Dang HX, Larson DE, Kulkarni S, et al. Comprehensive discovery of non-coding RNAs in acute myeloid leukemia cell transcriptomes. Experimental Hematology. PMID 28760689 DOI: 10.1016/J.Exphem.2017.07.008  0.59
2017 Wong TN, Link DC. miR-125b promotes leukemogenesis via VEGFA. Blood. 129: 1409-1410. PMID 28302689 DOI: 10.1182/Blood-2017-01-761544  0.63
2017 Fontana F, Hickman-Brecks CL, Salazar VS, Revollo L, Abou-Ezzi G, Grimston SK, Jeong SY, Watkins M, Fortunato M, Alippe Y, Link DC, Mbalaviele G, Civitelli R. N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 28240364 DOI: 10.1002/Jbmr.3112  0.38
2017 Spencer DH, Russler-Germain DA, Ketkar S, Helton NM, Lamprecht TL, Fulton RS, Fronick CC, O'Laughlin M, Heath SE, Shinawi M, Westervelt P, Payton JE, Wartman LD, Welch JS, Wilson RK, ... ... Link DC, et al. CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression. Cell. PMID 28215704 DOI: 10.1016/J.Cell.2017.01.021  0.679
2017 Duncavage EJ, Uy GL, Petti AA, Miller CA, Lee YS, Tandon B, Gao F, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Jacoby MA, Cashen AF, Wartman LD, Walter MJ, ... ... Link DC, et al. Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy. Blood. PMID 28082444 DOI: 10.1182/Blood-2016-10-745273  0.677
2017 Wong TN, Miller CA, Jotte MR, Bagegni N, Baty JD, Schmidt AE, Cashen AF, Duncavage EJ, Helton NM, Fiala MA, Fulton RS, Heath SE, Janke M, Luber K, Westervelt P, ... ... Link DC, et al. Cellular Stressors Contribute to the Expansion of Multiple Hematopoietic Clones of Varying Leukemic Potential Blood. 130: 469-469. DOI: 10.1182/Blood.V130.Suppl_1.469.469  0.741
2017 Yao J, Wong TN, Trissal M, Ramaswamy R, Sun Y, Reddy PR, Link DC. Abstract 3042:MIR142loss-of-function mutations promote leukemogenesis through derepression ofASH1Lresulting in increasedHOXgene expression Cancer Research. 77: 3042-3042. DOI: 10.1158/1538-7445.Am2017-3042  0.669
2016 Welch JS, Petti AA, Miller CA, Fronick CC, O'Laughlin M, Fulton RS, Wilson RK, Baty JD, Duncavage EJ, Tandon B, Lee YS, Wartman LD, Uy GL, Ghobadi A, Tomasson MH, ... ... Link DC, et al. TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes. The New England Journal of Medicine. 375: 2023-2036. PMID 27959731 DOI: 10.1056/Nejmoa1605949  0.737
2016 Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Elliott K, Reinick T, Fulton RS, Fronick CC, O'Laughlin M, Ganel L, Abboud CN, Cashen AF, ... ... Link DC, et al. Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy. Leukemia. PMID 27740633 DOI: 10.1038/Leu.2016.282  0.769
2016 Yao JC, Link DC. The Malignant Hematopoietic Stem Cell Niche. Stem Cells (Dayton, Ohio). PMID 27647718 DOI: 10.1002/Stem.2487  0.441
2016 Walji TA, Turecamo SE, Sanchez AC, Anthony BA, Abou-Ezzi G, Scheller EL, Link DC, Mecham RP, Craft CS. Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice. Frontiers in Endocrinology. 7: 87. PMID 27445989 DOI: 10.3389/Fendo.2016.00087  0.346
2016 Zhang J, Link DC. Targeting of Mesenchymal Stromal Cells by Cre-Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27237054 DOI: 10.1002/Jbmr.2877  0.395
2016 Griffith M, Griffith OL, Krysiak K, Skidmore ZL, Christopher MJ, Klco JM, Ramu A, Lamprecht TL, Wagner AH, Campbell KM, Lesurf R, Hundal J, Zhang J, Spies NC, Ainscough BJ, ... ... Link DC, et al. Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B lymphoblastic leukemia. Experimental Hematology. PMID 27181063 DOI: 10.1016/J.Exphem.2016.04.011  0.802
2016 Jacoby MA, Duncavage EJ, Chang GS, Miller CA, Shao J, Elliott K, Fulton RS, Fronick C, O'Laughlin M, Link DC, DiPersio JF, Westervelt P, Ley TJ, Graubert TA, Walter MJ, et al. Dynamic Changes in MDS Clonal Architecture Following Allogeneic Stem Cell Transplant Blood. 128: 5506-5506. DOI: 10.1182/Blood.V128.22.5506.5506  0.757
2016 Xia J, Shimamura A, Myers KC, Boxer LA, Dale DC, Ramesh A, Jotte M, Link DC. Mutation Burden in Hematopoietic Stem Cells Is Not Increased in Congenital Neutropenia Blood. 128: 405-405. DOI: 10.1182/Blood.V128.22.405.405  0.478
2016 Zhang J, Link DC, Supakorndej T, Rao M. Myeloid Dendritic Cells Contribute to Hematopoietic Homeostasis Blood. 128: 30-30. DOI: 10.1182/Blood.V128.22.30.30  0.694
2016 Yao J, Wong TN, Trissal M, Ramaswamy R, Sun Y, Ley TJ, Reddy PR, Link DC. MIR142 Loss-of-Function Mutations Promote Leukemogenesis through Derepression of ASH1L Resulting in Increased HOX Gene Expression Blood. 128: 2718-2718. DOI: 10.1182/Blood.V128.22.2718.2718  0.779
2016 Makaryan V, Fletcher B, Kelley ML, Bolyard AA, Link DC, Duncavage EJ, Qualls DA, Dale DC. TCIRG1 Mutations As a Cause for Chronic Neutropenia Blood. 128: 2511-2511. DOI: 10.1182/Blood.V128.22.2511.2511  0.32
2016 Christopher M, Petti AA, Miller C, Wartman LD, Payton JE, Heath S, Fulton R, Welch JS, Walter MJ, Westervelt P, Link DC, Wilson RK, Ley TJ, DiPersio JF. Clonal Evolution of Acute Myeloid Leukemia Following Allogeneic Stem Cell Transplantation Blood. 128: 1528-1528. DOI: 10.1182/Blood.V128.22.1528.1528  0.828
2016 Spencer D, Russler-Germain D, Helton NM, Lamprecht TL, Shinawi M, Westervelt P, Payton JE, Fulton RS, Wilson RK, Walter MJ, Link DC, DiPersio JF, Ley TJ. DNMT3A-Dependent DNA Methylation May Act As a Tumor Suppressor-Not a Tumor Promoter-during AML Progression Blood. 128: 1050-1050. DOI: 10.1182/Blood.V128.22.1050.1050  0.696
2015 Wong TN, Miller CA, Klco JM, Petti A, Demeter R, Helton NM, Li T, Fulton RS, Heath SE, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert TA, ... ... Link DC, et al. Rapid expansion of pre-existing non-leukemic hematopoietic clones frequently follows induction therapy for de novo AML. Blood. PMID 26631115 DOI: 10.1182/Blood-2015-10-677021  0.815
2015 Churpek JE, Pyrtel K, Kanchi KL, Shao J, Koboldt D, Miller CA, Shen D, Fulton R, O'Laughlin M, Fronick C, Pusic I, Uy GL, Braunstein EM, Levis M, Ross J, ... ... Link DC, et al. Genomic analysis of germline and somatic variants in familial myelodysplasia/acute myeloid leukemia. Blood. PMID 26492932 DOI: 10.1182/Blood-2015-04-641100  0.734
2015 Calvi LM, Link DC. The hematopoietic stem cell niche in homeostasis and disease. Blood. 126: 2443-51. PMID 26468230 DOI: 10.1182/Blood-2015-07-533588  0.4
2015 Uy GL, Hsu YS, Schmidt AP, Stock W, Fletcher TR, Trinkaus KM, Westervelt P, DiPersio JF, Link DC. Targeting bone marrow lymphoid niches in acute lymphoblastic leukemia. Leukemia Research. PMID 26467815 DOI: 10.1182/Blood.V122.21.1398.1398  0.478
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Helton NM, Duncavage EJ, Payton JE, Baty J, Heath SE, Griffith OL, ... ... Link DC, et al. Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia. Jama. 314: 811-22. PMID 26305651 DOI: 10.1001/Jama.2015.9643  0.788
2015 Day RB, Bhattacharya D, Nagasawa T, Link DC. Granulocyte colony-stimulating factor reprograms bone marrow stromal cells to actively suppress B lymphopoiesis in mice. Blood. 125: 3114-7. PMID 25814527 DOI: 10.1182/Blood-2015-02-629444  0.432
2015 Leong JW, Schneider SE, Sullivan RP, Parikh BA, Anthony BA, Singh A, Jewell BA, Schappe T, Wagner JA, Link DC, Yokoyama WM, Fehniger TA. PTEN regulates natural killer cell trafficking in vivo. Proceedings of the National Academy of Sciences of the United States of America. 112: E700-9. PMID 25646418 DOI: 10.1073/Pnas.1413886112  0.373
2015 Young AL, Wong TN, Hughes AE, Heath SE, Ley TJ, Link DC, Druley TE. Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing. Leukemia. 29: 1608-11. PMID 25644247 DOI: 10.1038/Leu.2015.17  0.771
2015 Lodhi IJ, Wei X, Yin L, Feng C, Adak S, Abou-Ezzi G, Hsu FF, Link DC, Semenkovich CF. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Cell Metabolism. 21: 51-64. PMID 25565205 DOI: 10.1016/J.Cmet.2014.12.002  0.327
2015 Wong TN, Ramsingh G, Young AL, Miller CA, Touma W, Welch JS, Lamprecht TL, Shen D, Hundal J, Fulton RS, Heath S, Baty JD, Klco JM, Ding L, Mardis ER, ... ... Link DC, et al. Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia. Nature. 518: 552-5. PMID 25487151 DOI: 10.1038/Nature13968  0.813
2015 Rao M, Supakorndej T, Schmidt AP, Link DC. Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice. Experimental Hematology. 43: 110-4.e1-2. PMID 25461255 DOI: 10.1016/J.Exphem.2014.10.012  0.68
2015 Makaryan V, Zeidler C, Bolyard AA, Skokowa J, Rodger E, Kelley ML, Boxer LA, Bonilla MA, Newburger PE, Shimamura A, Zhu B, Rosenberg PS, Link DC, Welte K, Dale DC. The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Current Opinion in Hematology. 22: 3-11. PMID 25427142 DOI: 10.1097/Moh.0000000000000105  0.344
2015 Welch JS, Petti A, Miller CA, Link DC, Walter MJ, Fronick CC, Fulton RS, Wartman LD, Uy GL, Ghobadi A, Tomasson M, Pusic I, Romee R, Fehniger TA, Stockerl-Goldstein K, et al. Dynamic Changes in Clonal Clearance with Decitabine Therapy in AML and MDS Patients Blood. 126: 689-689. DOI: 10.1182/Blood.V126.23.689.689  0.666
2015 Wong TN, Klco JM, Demeter R, Miller CA, Petti A, Havey N, Fulton R, Heath S, Mardis ER, Westervelt P, DiPersio JF, Walter MJ, Welch JS, Graubert T, Wilson RK, ... ... Link DC, et al. Non-Malignant Oligoclonal Hematopoiesis Commonly Follows Cytoreductive Chemotherapy in Adult De Novo AML Patients Blood. 126: 686-686. DOI: 10.1182/Blood.V126.23.686.686  0.824
2015 Abou Ezzi G, Suparkorndej T, Anthony B, Zhang J, Ganguly S, Civitelli R, Link DC. Loss of TGF-β Signaling in Bone Marrow Mesenchymal Progenitors Promotes Adipocyte over Osteoblast Differentiation but Does Not Disrupt the HSC Niche Blood. 126: 666-666. DOI: 10.1182/Blood.V126.23.666.666  0.446
2015 Uy GL, Duncavage EJ, Chang GS, Jacoby MA, Miller CA, Shao J, Heath S, Fulton RS, Fronick CC, O'Laughlin M, Abboud CN, Cashen AF, DiPersio JF, Wilson RK, Link DC, et al. Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy Blood. 126: 610-610. DOI: 10.1182/blood.v126.23.610.610  0.75
2015 Warner WA, Spencer D, Trissal M, Helton N, Ley TJ, Link DC. Characterization of snoRNA Expression in Acute Myeloid Leukemia Blood. 126: 3649-3649. DOI: 10.1182/Blood.V126.23.3649.3649  0.67
2015 Zhang J, Link DC. Targeting Bone Marrow Mesenchymal Stromal Cells Using Cre-Recombinase Transgenes Blood. 126: 2401-2401. DOI: 10.1182/Blood.V126.23.2401.2401  0.422
2015 Yao J, Wong TN, Trissal M, Sun Y, Ley TJ, Reddy P, Link DC. Loss-of-Function Mutations of MIR142 May Contribute to Leukemogenesis By Expanding the Pool of Myeloid-Biased HSCs Blood. 126: 1254-1254. DOI: 10.1182/Blood.V126.23.1254.1254  0.778
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, ... ... Link DC, et al. Abstract PR11: Genomic approaches for risk assessment in acute myeloid leukemia Cancer Research. 75. DOI: 10.1158/1538-7445.Transcagen-Pr11  0.817
2015 Klco JM, Miller CA, Griffith M, Petti A, Spencer DH, Ketkar-Kulkarni S, Wartman LD, Christopher M, Lamprecht TL, Payton JE, Baty J, Heath SE, Griffith OL, Shen D, Hundal J, ... ... Link DC, et al. Abstract PR03: Genomic approaches for risk assessment in acute myeloid leukemia Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr03  0.817
2015 Link DC. Regulation of hematopoiesis by cxcl12/cxcr4 signaling Targeted Therapy of Acute Myeloid Leukemi. 593-605. DOI: 10.1007/978-1-4939-1393-0_30  0.366
2014 Day RB, Link DC. Megakaryocytes in the hematopoietic stem cell niche. Nature Medicine. 20: 1233-4. PMID 25375920 DOI: 10.1038/Nm.3745  0.402
2014 Lu EP, McLellan M, Ding L, Fulton R, Mardis ER, Wilson RK, Miller CA, Westervelt P, DiPersio JF, Link DC, Walter MJ, Ley TJ, Graubert TA. Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice. Blood. 124: 3887-95. PMID 25349173 DOI: 10.1182/Blood-2014-06-582551  0.747
2014 Xie M, Lu C, Wang J, McLellan MD, Johnson KJ, Wendl MC, McMichael JF, Schmidt HK, Yellapantula V, Miller CA, Ozenberger BA, Welch JS, Link DC, Walter MJ, Mardis ER, et al. Age-related mutations associated with clonal hematopoietic expansion and malignancies. Nature Medicine. 20: 1472-8. PMID 25326804 DOI: 10.1038/Nm.3733  0.675
2014 Hughes AE, Magrini V, Demeter R, Miller CA, Fulton R, Fulton LL, Eades WC, Elliott K, Heath S, Westervelt P, Ding L, Conrad DF, White BS, Shao J, Link DC, et al. Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing. Plos Genetics. 10: e1004462. PMID 25010716 DOI: 10.1371/Journal.Pgen.1004462  0.734
2014 Wilson DB, Link DC, Mason PJ, Bessler M. Inherited bone marrow failure syndromes in adolescents and young adults. Annals of Medicine. 46: 353-63. PMID 24888387 DOI: 10.3109/07853890.2014.915579  0.346
2014 Panni RZ, Sanford DE, Belt BA, Mitchem JB, Worley LA, Goetz BD, Mukherjee P, Wang-Gillam A, Link DC, Denardo DG, Goedegebuure SP, Linehan DC. Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunology, Immunotherapy : Cii. 63: 513-28. PMID 24652403 DOI: 10.1007/S00262-014-1527-X  0.35
2014 Klco JM, Spencer DH, Miller CA, Griffith M, Lamprecht TL, O'Laughlin M, Fronick C, Magrini V, Demeter RT, Fulton RS, Eades WC, Link DC, Graubert TA, Walter MJ, Mardis ER, et al. Functional heterogeneity of genetically defined subclones in acute myeloid leukemia. Cancer Cell. 25: 379-92. PMID 24613412 DOI: 10.1016/J.Ccr.2014.01.031  0.743
2014 Schuettpelz LG, Borgerding JN, Christopher MJ, Gopalan PK, Romine MP, Herman AC, Woloszynek JR, Greenbaum AM, Link DC. G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia. 28: 1851-60. PMID 24518205 DOI: 10.1038/Leu.2014.68  0.81
2014 Anthony BA, Link DC. Regulation of hematopoietic stem cells by bone marrow stromal cells. Trends in Immunology. 35: 32-7. PMID 24210164 DOI: 10.1016/J.It.2013.10.002  0.429
2014 Calvi LM, Link DC. Cellular complexity of the bone marrow hematopoietic stem cell niche. Calcified Tissue International. 94: 112-24. PMID 24101231 DOI: 10.1007/S00223-013-9805-8  0.429
2014 Xia J, Link DC, Uy GL. G-CSF Augments Inotuzamab-Mediated Clearance of Acute Lymphoblastic Leukemia from the Bone Marrow Blood. 124: 5502-5502. DOI: 10.1182/Blood.V124.21.5502.5502  0.45
2014 Young A, Wong TN, Ley TJ, Link DC, Druley TE. Rare Hematopoietic Subclones Harboring Leukemogenic TP53 Mutations Are Detectable Via Error-Corrected Sequencing in Healthy Elderly Individuals Blood. 124: 2907-2907. DOI: 10.1182/Blood.V124.21.2907.2907  0.788
2014 Dale DC, Bolyard AA, Zeidler C, Marrero TM, Boxer LA, Newburger PE, Alter BP, Morrow P, Bonilla MA, Dror Y, Firkin F, Kinsey S, Levine JE, Link DC, Reeves L, et al. Understanding Neutropenia: The 20 Year Experience of the Severe Chronic Neutropenia International Registry (SCNIR) Blood. 124: 2730-2730. DOI: 10.1182/Blood.V124.21.2730.2730  0.391
2014 Klimenkova O, Klimiankou M, Schmidt A, Stocking C, Zeidler C, Link DC, Welte K, Skokowa J. Co-Acquisition of RUNX1 and CSF3R Mutations Transforms Hematopoietic Progenitor Cells of CN Patients into More Primitive Highly Proliferative Blasts: Evidence in CN Patients and in a Mouse Model Blood. 124: 223-223. DOI: 10.1182/Blood.V124.21.223.223  0.474
2013 Ramsingh G, Jacoby MA, Shao J, De Jesus Pizzaro RE, Shen D, Trissal M, Getz AH, Ley TJ, Walter MJ, Link DC. Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. Blood. 122: e44-51. PMID 24009227 DOI: 10.1182/Blood-2013-03-488007  0.616
2013 Schuettpelz LG, Link DC. Regulation of hematopoietic stem cell activity by inflammation. Frontiers in Immunology. 4: 204. PMID 23882270 DOI: 10.3389/Fimmu.2013.00204  0.451
2013 Link DC. SNAREing a new cause of neutropenia. Blood. 121: 4969-70. PMID 23788021 DOI: 10.1182/Blood-2013-05-498717  0.371
2013 Walter MJ, Shen D, Shao J, Ding L, White BS, Kandoth C, Miller CA, Niu B, McLellan MD, Dees ND, Fulton R, Elliot K, Heath S, Grillot M, Westervelt P, ... Link DC, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 27: 1275-82. PMID 23443460 DOI: 10.1038/Leu.2013.58  0.741
2013 Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 495: 227-30. PMID 23434756 DOI: 10.1038/Nature11926  0.821
2013 Link DC. Osteocytes link bone maintenance to blood homeostasis. Blood. 121: 867-8. PMID 23393015 DOI: 10.1182/Blood-2012-12-468637  0.383
2013 Link D. Mechanisms of Neutrophil Release from the Bone Marrow Blood. 122: SCI-43-SCI-43. DOI: 10.1182/Blood.V122.21.Sci-43.Sci-43  0.472
2013 Supakorndej T, Rao M, Link DC. Myeloid Dendritic Cells Regulate HSPC Trafficking In The Bone Marrow Blood. 122: 584-584. DOI: 10.1182/Blood.V122.21.584.584  0.711
2013 Neal Wong T, Ramsingh G, Young A, Shen D, Miller C, Lamprecht T, Heath S, Fulton RS, Mardis ER, Ding L, Westervelt P, Welch J, Walter MJ, Graubert T, DiPersio JF, ... ... Link DC, et al. The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML Blood. 122: 5-5. DOI: 10.1182/Blood.V122.21.5.5  0.749
2013 Trissal M, Silva J, Wylie T, Hundal J, McGrath S, Magrini V, Ramsingh G, Mardis ER, Ley TJ, Link DC. Dysregulation and Recurrent Mutation Of miRNA-142 In De Novo AML Blood. 122: 472-472. DOI: 10.1182/Blood.V122.21.472.472  0.627
2013 Schuettpelz LG, Borgerding JN, Gopalan P, Christopher M, Romine M, Woloszynek J, Greenbaum A, Link DC. G-CSF Treatment Induces Toll-Like Receptor Signaling and Regulates Hematopoietic Stem Cell Function Blood. 122: 1181-1181. DOI: 10.1182/Blood.V122.21.1181.1181  0.82
2012 Hsu YM, Link DC. Enhancing hematopoietic growth factor performance. Nature Medicine. 18: 1740-1. PMID 23223059 DOI: 10.1038/Nm.3022  0.309
2012 Link DC. Molecular genetics of AML. Best Practice & Research. Clinical Haematology. 25: 409-14. PMID 23200536 DOI: 10.1016/J.Beha.2012.10.002  0.381
2012 Schuettpelz LG, Gopalan PK, Giuste FO, Romine MP, van Os R, Link DC. Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood. 120: 2981-9. PMID 22936656 DOI: 10.1182/Blood-2012-02-409839  0.416
2012 Welch JS, Ley TJ, Link DC, Miller CA, Larson DE, Koboldt DC, Wartman LD, Lamprecht TL, Liu F, Xia J, Kandoth C, Fulton RS, McLellan MD, Dooling DJ, Wallis JW, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 150: 264-78. PMID 22817890 DOI: 10.1016/J.Cell.2012.06.023  0.755
2012 Walter MJ, Shen D, Ding L, Shao J, Koboldt DC, Chen K, Larson DE, McLellan MD, Dooling D, Abbott R, Fulton R, Magrini V, Schmidt H, Kalicki-Veizer J, O'Laughlin M, ... ... Link DC, et al. Clonal architecture of secondary acute myeloid leukemia. The New England Journal of Medicine. 366: 1090-8. PMID 22417201 DOI: 10.1056/Nejmoa1106968  0.767
2012 Greenbaum AM, Revollo LD, Woloszynek JR, Civitelli R, Link DC. N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood. 120: 295-302. PMID 22323481 DOI: 10.1182/Blood-2011-09-377457  0.714
2012 Ding L, Ley TJ, Larson DE, Miller CA, Koboldt DC, Welch JS, Ritchey JK, Young MA, Lamprecht T, McLellan MD, McMichael JF, Wallis JW, Lu C, Shen D, Harris CC, ... ... Link DC, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 481: 506-10. PMID 22237025 DOI: 10.1038/Nature10738  0.797
2012 Graubert TA, Shen D, Ding L, Okeyo-Owuor T, Lunn CL, Shao J, Krysiak K, Harris CC, Koboldt DC, Larson DE, McLellan MD, Dooling DJ, Abbott RM, Fulton RS, Schmidt H, ... ... Link DC, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nature Genetics. 44: 53-7. PMID 22158538 DOI: 10.1038/Ng.1031  0.749
2012 Day RB, Link DC. Regulation of neutrophil trafficking from the bone marrow. Cellular and Molecular Life Sciences : Cmls. 69: 1415-23. PMID 22045556 DOI: 10.1007/S00018-011-0870-8  0.398
2012 Xia J, Boxer LA, Link DC. ER Stress-Induced Expression of CCAAT/Enhancer Binding Protein Gamma (C/EBPG) May Contribute to the Block in Granulocytic Differentiation in Severe Congenital Neutropenia Blood. 120: 8-8. DOI: 10.1182/Blood.V120.21.8.8  0.427
2012 Ramsingh G, Shen D, Lamprecht T, Heath S, Fulton RS, Mardis ER, Ding L, Westervelt P, Welch JS, Walter MJ, Graubert T, DiPersio JF, Ley TJ, Wilson RK, Link DC. Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia Blood. 120: 784-784. DOI: 10.1182/Blood.V120.21.784.784  0.755
2012 Hsu YS, Greenbaum A, Schuettpelz LG, Christopher M, Borgerding JN, Day RB, Nagasawa T, Link DC. CXCL12 Production by Early Mesenchymal Progenitors Is Required for Hematopoietic Stem Cell Maintenance Blood. 120: 510-510. DOI: 10.1182/Blood.V120.21.510.510  0.822
2012 Trissal M, Spencer DH, Silva J, Wylie T, Hundal J, McGrath S, Magrini V, Ramsingh G, Wilson RJ, Ley TJ, Link DC. Dysregulation of the Imprinted DLK1-DIO3 Locus in Promyelocytic Leukemia Blood. 120: 3500-3500. DOI: 10.1182/Blood.V120.21.3500.3500  0.648
2012 Supakorndej T, Rao M, Link D. Myeloid Dendritic Cells Contribute to Hematopoietic Progenitor Mobilization by G-CSF. Blood. 120: 2319-2319. DOI: 10.1182/Blood.V120.21.2319.2319  0.7
2012 Dale DC, Bolyard AA, Marrero TM, Bonilla MA, Link DC, Newburger PE, Shimamura A, Boxer LA, Repository. The Natural History of Cyclic Neutropenia: Long-Term Prospective Observations and Current Perspectives. Blood. 120: 2141-2141. DOI: 10.1182/Blood.V120.21.2141.2141  0.362
2012 Borgerding JN, Gopalan P, Christopher M, Link DC, Schuettpelz LG. G-CSF Treatment Induces Hematopoietic Stem Cell Quiescence but Loss of Repopulating Activity Blood. 120: 1206-1206. DOI: 10.1182/Blood.V120.21.1206.1206  0.809
2011 Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuchi K. Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis. Blood. 118: 6939-42. PMID 22042698 DOI: 10.1182/Blood-2011-06-357210  0.438
2011 Kunter G, Woloszynek JR, Link DC. A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice. Experimental Hematology. 39: 1136-43. PMID 21911095 DOI: 10.1016/J.Exphem.2011.08.013  0.434
2011 Greenbaum A, Link DC. CXCR2 is the Tpo of the iceberg. Blood. 117: 4166-7. PMID 21511963 DOI: 10.1182/Blood-2011-02-332577  0.707
2011 Welch JS, Westervelt P, Ding L, Larson DE, Klco JM, Kulkarni S, Wallis J, Chen K, Payton JE, Fulton RS, Veizer J, Schmidt H, Vickery TL, Heath S, Watson MA, ... ... Link DC, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. Jama. 305: 1577-84. PMID 21505136 DOI: 10.1001/Jama.2011.497  0.718
2011 Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. Jama. 305: 1568-76. PMID 21505135 DOI: 10.1001/Jama.2011.473  0.734
2011 Schuettpelz LG, Link DC. Niche competition and cancer metastasis to bone. The Journal of Clinical Investigation. 121: 1253-5. PMID 21436576 DOI: 10.1172/Jci57229  0.348
2011 Nanua S, Murakami M, Xia J, Grenda DS, Woloszynek J, Strand M, Link DC. Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane. Blood. 117: 3539-47. PMID 21285438 DOI: 10.1182/Blood-2010-10-311704  0.793
2011 Christopher MJ, Rao M, Liu F, Woloszynek JR, Link DC. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. The Journal of Experimental Medicine. 208: 251-60. PMID 21282380 DOI: 10.1084/Jem.20101700  0.833
2011 Greenbaum AM, Link DC. Mechanisms of G-CSF-mediated hematopoietic stem and progenitor mobilization. Leukemia. 25: 211-7. PMID 21079612 DOI: 10.1038/Leu.2010.248  0.715
2011 Welch JS, Larson D, Ding L, McLellan MD, Lamprecht T, Kandoth C, Payton JE, Baty J, Harris CC, Lichti CF, Fulton RS, Dooling DJ, Koboldt DC, Schmidt H, Zhang Q, ... ... Link DC, et al. Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes Blood. 118: 404-404. DOI: 10.1182/Blood.V118.21.404.404  0.746
2011 Dale DC, Makaryan V, Bolyard AA, Rodger ER, Kelley ML, Marrero TM, Phan L, Aprikyan AA, Bonilla MA, Newburger PE, Boxer LA, Link D. ELANE Mutations in Cyclic and Congenital Neutropenia: Genotype-Phenotype Relationships, Blood. 118: 3398-3398. DOI: 10.1182/Blood.V118.21.3398.3398  0.373
2011 Day RB, Greenbaum A, Rao M, Link D. G-CSF Induces Alterations in the Bone Marrow Microenvironment That Suppress B Lymphopoiesis, Blood. 118: 3243-3243. DOI: 10.1182/Blood.V118.21.3243.3243  0.799
2011 Schuettpelz L, Giuste F, Gopalan P, Link D. Kruppel Like Factor 7 Suppresses Hematopoietic Stem and Progenitor Cell Function Blood. 118: 2356-2356. DOI: 10.1182/Blood.V118.21.2356.2356  0.445
2011 Olsson HA, Plassard A, Dexheimer P, Phelan JD, Melnick A, Xia J, Link DC, Opferman J, Aronow BJ, Grimes HL. Conserved Transcriptional Deregulation Underlies GFI1 and ELANE Mutant Neutropenia Blood. 118: 13-13. DOI: 10.1182/Blood.V118.21.13.13  0.455
2010 Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch J, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, ... ... Link DC, et al. DNMT3A mutations in acute myeloid leukemia. The New England Journal of Medicine. 363: 2424-33. PMID 21067377 DOI: 10.1056/Nejmoa1005143  0.741
2010 Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, et al. Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Research. 20: 1590-604. PMID 20935160 DOI: 10.1101/Gr.107995.110  0.615
2010 Link D. Stem cells on the move Nature Medicine. 16: 1073-1074. PMID 20930742 DOI: 10.1038/Nm1010-1073  0.375
2010 Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang LW, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, ... Link DC, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 116: 5316-26. PMID 20876853 DOI: 10.1182/Blood-2010-05-285395  0.633
2010 Eash KJ, Greenbaum AM, Gopalan PK, Link DC. CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. The Journal of Clinical Investigation. 120: 2423-31. PMID 20516641 DOI: 10.1172/Jci41649  0.823
2010 Rosová I, Link D, Nolta JA. shRNA-mediated decreases in c-Met levels affect the differentiation potential of human mesenchymal stem cells and reduce their capacity for tissue repair. Tissue Engineering. Part A. 16: 2627-39. PMID 20367286 DOI: 10.1089/Ten.Tea.2009.0363  0.793
2010 Gregory AD, Capoccia BJ, Woloszynek JR, Link DC. Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. Journal of Leukocyte Biology. 88: 123-31. PMID 20354107 DOI: 10.1189/Jlb.0709499  0.809
2010 Ramsingh G, Koboldt D, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Characterization of the microRNAome in a patient with acute myeloid leukemia. Journal of Clinical Oncology. 28: 10501-10501. DOI: 10.1200/Jco.2010.28.15_Suppl.10501  0.626
2010 Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, Kandoth C, Payton JE, Baty J, Welch JS, Harris CC, Lichti CF, Townsend RR, Fulton RS, Dooling DJ, ... ... Link DC, et al. Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes Blood. 116: 99-99. DOI: 10.1182/Blood.V116.21.99.99  0.75
2010 Schuettpelz L, Link DC, Shen D, Walter MJ, Koboldt DC, Dooling DJ, Fulton RS, Schmidt H, Maupin R, O'Laughlin M, Chen K, McLellan MD, Kulkarni S, Ivanovich J, Lebeau M, et al. DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia Blood. 116: 580-580. DOI: 10.1182/Blood.V116.21.580.580  0.754
2010 Kunter GM, Woloszynek J, Link DC. Alterations In the Bone Marrow Microenvironment Contribute to Oxidative Stress and DNA Damage In Hematopoietic Stem/Progenitors Carrying a Csf3r Truncation Mutation Blood. 116: 387-387. DOI: 10.1182/Blood.V116.21.387.387  0.439
2010 Dale DC, Makaryan V, Bolyard AA, Elin R, Aprikyan AA, Bonilla MA, Newburger PE, Boxer LA, Link D. Neutrophil Elastase Mutations and the Risk of Leukemia In Patients with Cyclic and Congenital Neutropenia. Blood. 116: 3786-3786. DOI: 10.1182/Blood.V116.21.3786.3786  0.407
2010 Ramsingh G, Matson A, Walter MJ, Link DC. High-Resolution Comparative Genomic Hybridization of Mirna Genes In Therapy-Related AML Identifies a Somatic Deletion of MiR-223 Blood. 116: 2759-2759. DOI: 10.1182/Blood.V116.21.2759.2759  0.308
2010 DiMeglio LA, Bolyard AA, Marrero TM, Alter BP, Bonilla MA, Boxer LA, Link D, Newburger PE, Rosenberg PS, Shimamura A, Dale DC. The Risk of Low Bone Mineral Density with Long-Term G-CSF Therapy for Severe Chronic Neutropenia. Blood. 116: 1484-1484. DOI: 10.1182/Blood.V116.21.1484.1484  0.33
2010 Fehniger TA, Wylie T, Germino E, Leong JW, Magrini VJ, Koul S, Keppel CR, Schneider SE, Koboldt DC, Sullivan RP, Heinz ME, Crosby SD, Nagarajan R, Ramsingh G, Link DC, et al. The NK Cell MicroRNA Transcriptome Defined by Next-Generation Sequencing Identifies IL-15-Signaled Alterations In Mature MiR-223 Expression, and MiR-223 as a Potential Regulator of Murine Granzyme B Blood. 116: 104-104. DOI: 10.1182/Blood.V116.21.104.104  0.609
2010 Ramsingh G, Koboldt DC, Trissal M, Chiappinelli KB, Wylie T, Koul S, Chang L, Nagarajan R, Fehniger TA, Goodfellow P, Magrini V, Wilson RK, Ding L, Ley TJ, Mardis ER, ... Link DC, et al. Abstract B12: Complete characterization of the “microRNAome” of a human acute myeloid leukemia Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-B12  0.624
2009 Xia J, Bolyard AA, Rodger E, Stein S, Aprikyan AA, Dale DC, Link DC. Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. British Journal of Haematology. 147: 535-42. PMID 19775295 DOI: 10.1111/J.1365-2141.2009.07888.X  0.38
2009 Shaked Y, Tang T, Woloszynek J, Daenen LG, Man S, Xu P, Cai SR, Arbeit JM, Voest EE, Chaplin DJ, Smythe J, Harris A, Nathan P, Judson I, Rustin G, ... ... Link DC, et al. Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Research. 69: 7524-8. PMID 19738066 DOI: 10.1158/0008-5472.Can-09-0381  0.367
2009 Mardis ER, Ding L, Dooling DJ, Larson DE, McLellan MD, Chen K, Koboldt DC, Fulton RS, Delehaunty KD, McGrath SD, Fulton LA, Locke DP, Magrini VJ, Abbott RM, Vickery TL, ... ... Link DC, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. The New England Journal of Medicine. 361: 1058-66. PMID 19657110 DOI: 10.1056/Nejmoa0903840  0.747
2009 Walter MJ, Payton JE, Ries RE, Shannon WD, Deshmukh H, Zhao Y, Baty J, Heath S, Westervelt P, Watson MA, Tomasson MH, Nagarajan R, O'Gara BP, Bloomfield CD, Mrózek K, ... ... Link DC, et al. Acquired copy number alterations in adult acute myeloid leukemia genomes. Proceedings of the National Academy of Sciences of the United States of America. 106: 12950-5. PMID 19651600 DOI: 10.1073/Pnas.0903091106  0.718
2009 Payton JE, Grieselhuber NR, Chang LW, Murakami M, Geiss GK, Link DC, Nagarajan R, Watson MA, Ley TJ. High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. The Journal of Clinical Investigation. 119: 1714-26. PMID 19451695 DOI: 10.1172/Jci38248  0.784
2009 Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood. 113: 5340-51. PMID 19324906 DOI: 10.1182/Blood-2008-04-154567  0.753
2009 Eash KJ, Means JM, White DW, Link DC. CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood. 113: 4711-9. PMID 19264920 DOI: 10.1182/Blood-2008-09-177287  0.816
2009 Christopher MJ, Liu F, Hilton MJ, Long F, Link DC. Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood. 114: 1331-9. PMID 19141863 DOI: 10.1182/Blood-2008-10-184754  0.811
2009 Rao M, Christopher M, Woloszynek J, Liu F, Link DC. Expression of the G-CSF Receptor in Monocytes Is Sufficient to Mediate Osteoblast Suppression and HSPC Mobilization by G-CSF in Mice. Blood. 114: 563-563. DOI: 10.1182/Blood.V114.22.563.563  0.822
2009 Nanua S, Xia J, Murakami M, Woloszynek J, Link DC. Loss of PERK Signaling Results in Impaired Granulopoiesis in Transgenic Mice Expressing Mutant Ela2. Blood. 114: 551-551. DOI: 10.1182/Blood.V114.22.551.551  0.42
2009 Kunter GM, Woloszynek J, Ley T, Link DC. Increased ROS Stress and Alterations in the Bone Marrow Microenvironment Contribute to DNA Damage in Hematopoietic Stem/Progenitors Carrying a Csf3r Truncation Mutation. Blood. 114: 3630-3630. DOI: 10.1182/Blood.V114.22.3630.3630  0.698
2009 Zeidler C, Donadieu J, Bolyard AA, Vandenberghe P, Pracht G, Beaupain B, Hoy L, Zimmermann M, Bellanne-Chantelot C, Link DC, Klein C, Germeshausen M, Dale DC, Welte K. Update On the Risk of Leukemia in Genetic Subgroups of Congenital Neutropenia (CN): Comparison of Patients with Known Gene Mutations (ELA2, HAX1, WASP, G6PC3, p14). Blood. 114: 3597-3597. DOI: 10.1182/Blood.V114.22.3597.3597  0.385
2009 Ramsingh G, Koboldt DC, Fehniger TA, Wylie T, Magrini V, Trissal M, Koul S, Chang L, Nagarajan R, Ley TJ, Mardis E, Link DC. Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia. Blood. 114: 271-271. DOI: 10.1182/Blood.V114.22.271.271  0.634
2009 Eash KJ, Greenbaum AM, Gopalan P, Diaz GA, Link DC. CXCR2 Signals Act in Concert with CXCR4 to Regulate Neutrophil Release From the Bone Marrow. Blood. 114: 235-235. DOI: 10.1182/Blood.V114.22.235.235  0.827
2008 Ley TJ, Mardis ER, Ding L, Fulton B, McLellan MD, Chen K, Dooling D, Dunford-Shore BH, McGrath S, Hickenbotham M, Cook L, Abbott R, Larson DE, Koboldt DC, Pohl C, ... ... Link DC, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 456: 66-72. PMID 18987736 DOI: 10.1038/Nature07485  0.749
2008 Christopher MJ, Link DC. Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 23: 1765-74. PMID 18597629 DOI: 10.1359/Jbmr.080612  0.796
2008 Hunter MG, McLemore M, Link DC, Loveland M, Copelan A, Avalos BR. Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML. Plos One. 3: e2452. PMID 18560579 DOI: 10.1371/Journal.Pone.0002452  0.362
2008 Capoccia BJ, Gregory AD, Link DC. Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. Journal of Leukocyte Biology. 84: 760-8. PMID 18550788 DOI: 10.1189/Jlb.1107756  0.806
2008 Rosová I, Dao M, Capoccia B, Link D, Nolta JA. Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells (Dayton, Ohio). 26: 2173-82. PMID 18511601 DOI: 10.1634/Stemcells.2007-1104  0.798
2008 Devine SM, Vij R, Rettig M, Todt L, McGlauchlen K, Fisher N, Devine H, Link DC, Calandra G, Bridger G, Westervelt P, Dipersio JF. Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood. 112: 990-8. PMID 18426988 DOI: 10.1182/Blood-2007-12-130179  0.356
2008 Zhou P, Hohm S, Capoccia B, Wirthlin L, Hess D, Link D, Nolta J. Immunodeficient mouse models to study human stem cell-mediated tissue repair. Methods in Molecular Biology (Clifton, N.J.). 430: 213-25. PMID 18370302 DOI: 10.1007/978-1-59745-182-6_15  0.352
2008 Liu F, Kunter G, Krem MM, Eades WC, Cain JA, Tomasson MH, Hennighausen L, Link DC. Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. The Journal of Clinical Investigation. 118: 946-55. PMID 18292815 DOI: 10.1172/Jci32704  0.455
2008 Tomasson MH, Xiang Z, Walgren R, Zhao Y, Kasai Y, Miner T, Ries RE, Lubman O, Fremont DH, McLellan MD, Payton JE, Westervelt P, DiPersio JF, Link DC, Walter MJ, et al. Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood. 111: 4797-808. PMID 18270328 DOI: 10.1182/Blood-2007-09-113027  0.759
2008 Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner TL, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, et al. Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood. 111: 4809-12. PMID 18160671 DOI: 10.1182/Blood-2007-05-090308  0.766
2008 Xia J, Link DC. Severe congenital neutropenia and the unfolded protein response. Current Opinion in Hematology. 15: 1-7. PMID 18043239 DOI: 10.1097/Moh.0B013E3282F13Cd2  0.303
2008 Rosenberg PS, Alter BP, Link DC, Stein S, Rodger E, Bolyard AA, Aprikyan AA, Bonilla MA, Dror Y, Kannourakis G, Newburger PE, Boxer LA, Dale DC. Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. British Journal of Haematology. 140: 210-3. PMID 18028488 DOI: 10.1111/J.1365-2141.2007.06897.X  0.397
2008 Gregory AD, Capoccia BJ, Link DC. Conditioning of Monocytes in the Bone Marrow by Inflammatory Cytokines Inhibits Their Angiogenic Potential at Peripheral Sites of Ischemia Blood. 112: 471-471. DOI: 10.1182/Blood.V112.11.471.471  0.797
2008 Xia J, Bolyard AA, Rodger E, Stein S, Aprikyan AA, Dale DC, Link DC. Incidence of SCN-Assoicated Gene Mutations in Severe Congenital Neutropenia Patients in North America Blood. 112: 3553-3553. DOI: 10.1182/Blood.V112.11.3553.3553  0.372
2008 Christopher M, Link DC. Bone Marrow Monocyte/Macrophages Provide Signals Necessary for Osteoblast Maintenance: Potential Role for Insulin-Like Growth Factor Signaling Blood. 112: 323-323. DOI: 10.1182/Blood.V112.11.323.323  0.812
2008 Murakami M, Woloszynek J, Xia J, Liu F, Link D. Induction of the Unfolded Protein Response but Normal Basal Granulopoiesis in Mice Expressing G192X ELA2 Blood. 112: 314-314. DOI: 10.1182/Blood.V112.11.314.314  0.423
2008 Gopalan PK, Christopher MJ, Greenbaum AM, Link DC. Disruption of the Osteoblast Niche by G-CSF Is Associated with Hematopoietic Stem Cell Quiescence and Loss of Long-Term Repopulating Activity: Role of Cdkn1a Blood. 112: 2447-2447. DOI: 10.1182/Blood.V112.11.2447.2447  0.827
2007 Grenda DS, Murakami M, Ghatak J, Xia J, Boxer LA, Dale D, Dinauer MC, Link DC. Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood. 110: 4179-87. PMID 17761833 DOI: 10.1182/Blood-2006-11-057299  0.802
2007 Rawls AS, Gregory AD, Woloszynek JR, Liu F, Link DC. Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential. Blood. 110: 2414-22. PMID 17638857 DOI: 10.1182/Blood-2006-03-007112  0.761
2007 Link DC, Kunter G, Kasai Y, Zhao Y, Miner T, McLellan MD, Ries RE, Kapur D, Nagarajan R, Dale DC, Bolyard AA, Boxer LA, Welte K, Zeidler C, Donadieu J, et al. Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia. Blood. 110: 1648-55. PMID 17494858 DOI: 10.1182/Blood-2007-03-081216  0.76
2007 Gregory AD, Hogue LA, Ferkol TW, Link DC. Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood. 109: 3235-43. PMID 17185469 DOI: 10.1182/Blood-2005-01-015081  0.721
2007 Christopher MJ, Link DC. Regulation of neutrophil homeostasis. Current Opinion in Hematology. 14: 3-8. PMID 17133093 DOI: 10.1097/00062752-200701000-00003  0.785
2007 Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, Ley TJ. Commonly dysregulated genes in murine APL cells. Blood. 109: 961-70. PMID 17008535 DOI: 10.1182/Blood-2006-07-036640  0.664
2007 Xiang Z, Zhao Y, Mitaksov V, Fremont DH, Kasai Y, Molitoris A, Ries RE, Miner T, McLellan MD, DiPersio JF, Link DC, Payton JE, Graubert TA, Watson M, Shannon W, et al. Identification of Novel, Non-Synonymous Sequence Changes in the Tyrosine Kinase Genes of Patients with Acute Myeloid Leukemia. Blood. 110: 823-823. DOI: 10.1182/Blood.V110.11.823.823  0.761
2007 Payton JE, Grieselhuber NR, Chang L, Murakami MA, Yuan W, Link DC, Nagarajan R, Watson MA, Ley TJ. The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes. Blood. 110: 719-719. DOI: 10.1182/Blood.V110.11.719.719  0.791
2007 Murakami M, Xia J, Jordan CT, Boxer LA, Dale D, Bolyard AA, Dinauer MC, Link DC. Granulocytic Precursors from Patients with ELA2-Mutant Severe Congenital Neutropenia Display a Transcriptional Profile Consistent with Activation of the Unfolded Protein Response. Blood. 110: 662-662. DOI: 10.1182/Blood.V110.11.662.662  0.406
2007 Levac KD, Robson DL, Neelamkavil MJ, Hohm SA, Capoccia BJ, Link DC, Nolta JA, Hess DA. Aldehyde Dehydrogenase-Activity Purifies Multiple Hemangiogenic Lineages That Accelerate Vascularization of Ischemic Tissue through Paracrine Support of Neovessel Formation. Blood. 110: 3716-3716. DOI: 10.1182/Blood.V110.11.3716.3716  0.754
2007 Boxer LA, Bolyard AA, Newburger PE, Bonilla MA, Kannourakis G, Dror Y, Link DC, Alter BP, Rosenberg PS, Dale DC. Predictors of Transformation to Myelodysplasia/Acute Myelogenous Leukemia (MDS/AML) in Severe Congenital Neutropenia (SCN). Blood. 110: 3307-3307. DOI: 10.1182/Blood.V110.11.3307.3307  0.433
2007 Dale DC, Bolyard AA, Newburger PE, Bonilla MA, Kannourakis G, Dror Y, Link DC, Alter BP, Rosenberg PS, Boxer LA. Cyclic Neutropenia Is Not Associated with Transformation to MDS and AML. Blood. 110: 3306-3306. DOI: 10.1182/Blood.V110.11.3306.3306  0.369
2007 Eash KJ, Means JM, Woloszynek JR, Liu F, Link DC. CXCR4 Signals Regulate Neutrophil Release from the Bone Marrow but Not Clearance from the Circulation. Blood. 110: 3297-3297. DOI: 10.1182/Blood.V110.11.3297.3297  0.826
2007 Gregory AD, Capoccia BJ, Link DC. The Inflammatory Subset of Monocytes Stimulates Angiogenesis at Sites of Ischemia by Altering the Balance of Pro- and Anti-Inflammatory Cytokines. Blood. 110: 240-240. DOI: 10.1182/Blood.V110.11.240.240  0.795
2007 Gopalan PK, Christopher MJ, Link DC. Disruption of the Osteoblast Niche by G-CSF Induces Hematopoietic Stem Cell Quiescence and Loss of Long-Term Repopulating Activity. Blood. 110: 2217-2217. DOI: 10.1182/Blood.V110.11.2217.2217  0.808
2007 Woloszynek JR, Kunter GM, Ley T, Link DC. G-CSFSR Mutations Present in Patients with Severe Congenital Neutropenia Cooperate with PML-RARα To Induce Acute Myeloid Leukemia in Mice. Blood. 110: 2193-2193. DOI: 10.1182/Blood.V110.11.2193.2193  0.447
2007 Ley TJ, DiPersio J, Ding L, Ries R, Magrini V, Payton J, McGrath S, Walter M, Wylie T, Dunford-Shore B, Chen K, McLellan M, Wendl M, Dooling D, Cook L, ... ... Link D, et al. Sequencing an Acute Myeloid Leukemia (AML) Genome with “Next Generation” Technologies. Blood. 110: 205-205. DOI: 10.1182/Blood.V110.11.205.205  0.745
2007 Walter MJ, Ries R, Li X, Shannon W, Payton J, Books J, Bloomfield C, Mrozek K, Ruppert A, DiPersio J, Link D, Tomasson M, Graubert T, Westervelt P, Watson M, et al. High Resolution Array-Based CGH and SNP Studies of AML Genomes. Blood. 110: 107-107. DOI: 10.1182/Blood.V110.11.107.107  0.722
2006 Güven H, Shepherd RM, Bach RG, Capoccia BJ, Link DC. The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. Journal of the American College of Cardiology. 48: 1579-87. PMID 17045891 DOI: 10.1016/J.Jacc.2006.04.101  0.705
2006 Shepherd RM, Capoccia BJ, Devine SM, Dipersio J, Trinkaus KM, Ingram D, Link DC. Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood. 108: 3662-7. PMID 16912220 DOI: 10.1182/Blood-2006-06-030577  0.732
2006 Nervi B, Link DC, DiPersio JF. Cytokines and hematopoietic stem cell mobilization Journal of Cellular Biochemistry. 99: 690-705. PMID 16888804 DOI: 10.1002/Jcb.21043  0.407
2006 Panopoulos AD, Zhang L, Snow JW, Jones DM, Smith AM, El Kasmi KC, Liu F, Goldsmith MA, Link DC, Murray PJ, Watowich SS. STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood. 108: 3682-90. PMID 16888100 DOI: 10.1182/Blood-2006-02-003012  0.434
2006 Grenda DS, Link DC. 5. Mechanisms of disordered granulopoiesis in congenital neutropenia. Current Topics in Developmental Biology. 74: 133-76. PMID 16860667 DOI: 10.1016/S0070-2153(06)74005-4  0.768
2006 Mermel CH, McLemore ML, Liu F, Pereira S, Woloszynek J, Lowell CA, Link DC. Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood. 108: 2562-8. PMID 16772601 DOI: 10.1182/Blood-2006-05-024307  0.366
2006 Capoccia BJ, Shepherd RM, Link DC. G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood. 108: 2438-45. PMID 16735597 DOI: 10.1182/Blood-2006-04-013755  0.736
2006 Khanna-Gupta A, Sun H, Zibello T, Lozovatsky L, Ghosh PK, Link DC, McLemore ML, Berliner N. p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation. Journal of Leukocyte Biology. 79: 1011-21. PMID 16641140 DOI: 10.1189/Jlb.0205066  0.431
2006 Gamero AM, Potla R, Wegrzyn J, Szelag M, Edling AE, Shimoda K, Link DC, Dulak J, Baker DP, Tanabe Y, Grayson JM, Larner AC. Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. The Journal of Biological Chemistry. 281: 16238-44. PMID 16601124 DOI: 10.1074/Jbc.M509516200  0.354
2006 Christopher MJ, Gopalan PK, Link DC. G-CSF Disrupts the Stem Cell Niche by Increasing Turnover of Bone Marrow Osteoblasts. Blood. 108: 87-87. DOI: 10.1182/Blood.V108.11.87.87  0.799
2006 Eash KJ, Link DC. CXCR4 Signals Regulate Basal and G-CSF Induced Neutrophil Release from the Bone Marrow. Blood. 108: 673-673. DOI: 10.1182/Blood.V108.11.673.673  0.83
2006 Kunter GM, Liu F, Krem M, Link D. G-CSF Receptor Mutations Found in Patients with Severe Congenital Neutropenia Confer a Strong Competitive Growth Advantage at the Hematopoietic Stem Cell Level That Is Mediated by STAT5 Activation. Blood. 108: 632-632. DOI: 10.1182/Blood.V108.11.632.632  0.417
2006 Devine SM, Vij R, Todt L, McLaughlin K, Fisher N, Morris N, Link DC, Calandra G, Bridger G, DiPersio JF. HLA-Matched Sibling Donor Stem Cell Mobilization Can Be Safely and Effectively Reduced from a Five Day to a One Day Process by a Direct Antagonist of the CXCR4/SDF-1 Interaction. Blood. 108: 53-53. DOI: 10.1182/Blood.V108.11.53.53  0.348
2006 Capoccia BJ, Link DC. The Differential Role of Stromal Derived Factor-1 (SDF-1) and Monocyte Chemoattractant Protein-1 (MCP-1) in the Recruitment of Angiogenic Cells to Ischemic Tissue. Blood. 108: 417-417. DOI: 10.1182/Blood.V108.11.417.417  0.768
2006 Yuan W, Payton JE, Holt MS, Link DC, Watson MA, DiPersio JF, James Ley T. Commonly Dysregulated Genes in Murine Acute Promyelocytic Leukemia (APL) Cells. Blood. 108: 1925-1925. DOI: 10.1182/Blood.V108.11.1925.1925  0.396
2006 Sheehan AM, Ford LE, Link DC, Zutter MM. The α2β1 Integrin Regulates Hematopoietic Stem Cell Engraftment. Blood. 108: 1328-1328. DOI: 10.1182/Blood.V108.11.1328.1328  0.427
2006 Devine S, Todt L, Bonde J, Hess D, Devine H, Nolta J, Link D, Calandra G, Bridger G, DiPersio J. A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies Biology of Blood and Marrow Transplantation. 12: 35. DOI: 10.1182/Blood.V104.11.3341.3341  0.337
2005 Link DC. Neutrophil homeostasis: a new role for stromal cell-derived factor-1. Immunologic Research. 32: 169-78. PMID 16106067 DOI: 10.1385/Ir:32:1-3:169  0.41
2005 Grenda D, Link DC. A comparison of cyclic neutropenia in childhood and severe congenital neutropenia. Haematologica. 90: 1010A. PMID 16079089  0.751
2005 Semerad CL, Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque JP, Chappel J, Ross FP, Link DC. G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood. 106: 3020-7. PMID 16037394 DOI: 10.1182/Blood-2004-01-0272  0.827
2005 Grenda DS, Link DC. Neutrophil differentiation. Haematologica. 90: 2. PMID 15644299  0.763
2005 Grenda DS, Link DC. Mutations in the ELA2 Gene Encoding Neutrophil Elastase Induce the Unfolded Protein Response and May Contribute to Neutropenia through the UPR-Dependent Apoptosis of Granulocytic Precursors. Blood. 106: 91-91. DOI: 10.1182/Blood.V106.11.91.91  0.818
2005 Rawls AS, Woloszynek JR, Link DC. Lentiviral-Mediated RNAi Knockdown of SBDS in Murine Hematopoietic Progenitors Impairs Their Engraftment Potential and Granulocytic Differentiation. Blood. 106: 635-635. DOI: 10.1182/Blood.V106.11.635.635  0.429
2005 Christopher MJ, Liu F, Short B, Simmons PJ, Winkler I, Levesque J, Link DC. G-CSF Potently Suppresses Osteoblast Activity in the Bone Marrow. Blood. 106: 591-591. DOI: 10.1182/Blood.V106.11.591.591  0.811
2005 Rettig M, Holt M, Liu F, Ritchey J, Link D, Bridger G, DiPersio J. Evaluation of the Phenotype and GVHD-Inducing Potential of Splenic T Cells Isolated from G-CSF, AMD3100, or G-CSF and AMD3100 Pretreated Allogeneic Donors. Blood. 106: 5224-5224. DOI: 10.1182/Blood.V106.11.5224.5224  0.361
2005 Shepherd RM, Capoccia BJ, Devine SM, Ingram DA, Link DC. AMD3100 and G-CSF Mobilize Angiogenic Cells into the Blood of Healthy Donors. Blood. 106: 3022-3022. DOI: 10.1182/blood.v106.11.3022.3022  0.731
2005 Capoccia BJ, Wirthlin L, Shepherd R, O’Dell K, Nolta JA, Link DC, Hess DA. Bone Marrow-Derived Aldehyde Dehdrogenase Expressing Cells Possess Endothelial Progenitor Function in Addition to Hematopoietic Repopulating Ability and Aid in Blood Flow Recovery after Acute Ischemic Injury. Blood. 106: 2663-2663. DOI: 10.1182/Blood.V106.11.2663.2663  0.735
2005 Walter MJ, Ries RR, Li XD, Shannon WJ, Payton J, Bloomfield CD, Mrozek K, Ruppert AS, DiPersio J, Link D, Tomasson M, Graubert T, McLeod H, Devine S, Watson M, et al. Detection of Microdeletions and Amplifications in Primary Human Acute Myeloid Leukemia (AML) Genomes Using Ultradense Oligomer Tiling Path Arrays and Comparative Genomic Hybridization (CGH). Blood. 106: 2350-2350. DOI: 10.1182/Blood.V106.11.2350.2350  0.72
2004 Han B, Unsinger J, Liu F, Link DC, Bessler M. G-CSF induced progenitor mobilization in mice with PIGA - Blood cells Hematology Journal. 5: 347-352. PMID 15297852 DOI: 10.1038/Sj.Thj.6200383  0.481
2004 Woloszynek JR, Rothbaum RJ, Rawls AS, Minx PJ, Wilson RK, Mason PJ, Bessler M, Link DC. Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome. Blood. 104: 3588-90. PMID 15284109 DOI: 10.1182/Blood-2004-04-1516  0.383
2004 Levesque JP, Liu F, Simmons PJ, Betsuyaku T, Senior RM, Pham C, Link DC. Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood. 104: 65-72. PMID 15010367 DOI: 10.1182/Blood-2003-05-1589  0.428
2004 Zhang Y, Woodward VK, Shelton JM, Richardson JA, Zhou XJ, Link D, Kielar ML, Jeyarajah DR, Lu CY. Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro. American Journal of Physiology-Renal Physiology. 286. PMID 14734360 DOI: 10.1152/Ajprenal.00379.2002  0.363
2004 Grenda DS, Liu F, Richards M, Link DC. G-CSF Receptor Mutations Found in Patients with Severe Congenital Neutropenia Confer a Strong Competitive Advantage at the Hematopoeitic Stem Cell Level That Is Dependent on Increased Systemic Levels of G-CSF. Blood. 104: 457-457. DOI: 10.1182/Blood.V104.11.457.457  0.832
2004 Christopher MJ, Liu F, Everly N, Link DC. Disruption of SDF-1/CXCR4 Signaling during Flt-3 Ligand and Stem Cell Factor (SCF) Induced Hematopoietic Progenitor Mobilization. Blood. 104: 4139-4139. DOI: 10.1182/Blood.V104.11.4139.4139  0.788
2004 Capoccia BJ, Shepherd RM, Guven H, Devine SM, Link DC. A Comparison of the Ability of AMD3100 Versus G-CSF to Induce Angiogenesis and Mobilize Endothelial Progenitor Cells (EPCs). Blood. 104: 3597-3597. DOI: 10.1182/Blood.V104.11.3597.3597  0.741
2004 Devine SM, Link D, DiPersio JF. Novel strategies for hematopoietic stem cell mobilization Current Opinion in Organ Transplantation. 9: 54-63. DOI: 10.1097/00075200-200403000-00012  0.333
2003 Cottler-Fox MH, Lapidot T, Petit I, Kollet O, DiPersio JF, Link D, Devine S. Stem cell mobilization. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 419-37. PMID 14633793 DOI: 10.1182/Asheducation-2003.1.419  0.392
2003 Ley TJ, Minx PJ, Walter MJ, Ries RE, Sun H, McLellan M, DiPersio JF, Link DC, Tomasson MH, Graubert TA, McLeod H, Khoury H, Watson M, Shannon W, Trinkaus K, et al. A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 14275-80. PMID 14614138 DOI: 10.1073/Pnas.2335924100  0.756
2003 Watters JW, Kloss EF, Link DC, Graubert TA, McLeod HL. A mouse-based strategy for cyclophosphamide pharmacogenomic discovery. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1352-60. PMID 12970373 DOI: 10.1152/Japplphysiol.00214.2003  0.58
2003 Richards MK, Liu F, Iwasaki H, Akashi K, Link DC. Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood. 102: 3562-8. PMID 12893769 DOI: 10.1182/Blood-2003-02-0593  0.408
2002 Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC. G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity. 17: 413-23. PMID 12387736 DOI: 10.1016/S1074-7613(02)00424-7  0.822
2002 Grenda DS, Johnson SE, Mayer JR, McLemore ML, Benson KF, Horwitz M, Link DC. Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Blood. 100: 3221-8. PMID 12384420 DOI: 10.1182/Blood-2002-05-1372  0.833
2002 Thomas J, Liu F, Link DC. Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Current Opinion in Hematology. 9: 183-9. PMID 11953662 DOI: 10.1097/00062752-200205000-00002  0.439
2001 McLemore ML, Grewal S, Liu F, Archambault A, Poursine-Laurent J, Haug J, Link DC. STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation Immunity. 14: 193-204. PMID 11239451 DOI: 10.1016/S1074-7613(01)00101-7  0.418
2001 Link DC. Regulation of granulopoiesis: lessons from leukocyte adhesion deficiency Blood. 98: 3178-3178. DOI: 10.1182/Blood.V98.12.3178  0.341
2000 Liu F, Poursine-Laurent J, Link DC. Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF Blood. 95: 3025-3031. PMID 10807765 DOI: 10.1182/Blood.V95.10.3025.010K32_3025_3031  0.448
2000 Link DC. Mechanisms of granulocyte colony-stimulating factor induced hematopoietic progenitor-cell mobilization Seminars in Hematology. 37: 25-32. PMID 10718156 DOI: 10.1016/S0037-1963(00)90086-6  0.37
1999 Semerad CL, Poursine-Laurent J, Liu F, Link DC. A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation. Immunity. 11: 153-61. PMID 10485650 DOI: 10.1016/S1074-7613(00)80090-4  0.799
1999 Betsuyaku T, Liu F, Senior RM, Haug JS, Brown EJ, Jones SL, Matsushima K, Link DC. A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation. The Journal of Clinical Investigation. 103: 825-32. PMID 10079103 DOI: 10.1172/Jci5191  0.333
1998 Zhang P, Iwama A, Datta MW, Darlington GJ, Link DC, Tenen DG. Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein α (C/EBPα) is critical for granulopoiesis Journal of Experimental Medicine. 188: 1173-1184. PMID 9743535 DOI: 10.1084/Jem.188.6.1173  0.312
1998 McLemore ML, Poursine-Laurent J, Link DC. Increased granulocyte colony-stimulating factor responsiveness but normal resting granulopoiesis in mice carrying a targeted granulocyte colony- stimulating factor receptor mutation derived from a patient with severe congenital neutropenia Journal of Clinical Investigation. 102: 483-492. PMID 9691084 DOI: 10.1172/Jci3216  0.45
1998 Jacob J, Haug JS, Raptis S, Link DC. Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF- dependent granulocytic differentiation Blood. 92: 353-361. PMID 9657731 DOI: 10.1182/Blood.V92.2.353.414K37_353_361  0.374
1997 Liu F, Poursine-Laurent J, Wu HY, Link DC. Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation Blood. 90: 2583-2590. PMID 9326224 DOI: 10.1182/Blood.V90.7.2583.2583_2583_2590  0.348
1997 Liu F, Poursine-Laurent J, Link DC. The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not Flt-3 ligand Blood. 90: 2522-2528. PMID 9326216 DOI: 10.1182/Blood.V90.7.2522.2522_2522_2528  0.421
1996 Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice Immunity. 5: 491-501. PMID 8934575 DOI: 10.1016/S1074-7613(00)80504-X  0.414
1996 Rodel JE, Link DC. Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation Blood. 87: 858-864. PMID 8562953 DOI: 10.1182/Blood.V87.3.858.Bloodjournal873858  0.394
1995 Link DC, Zutter M. The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo Blood. 85: 472-479. PMID 7812001 DOI: 10.1182/Blood.V85.2.472.Bloodjournal852472  0.318
1992 Link DC, Gutkind SJ, Robbins KC, Ley TJ. Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter Oncogene. 7: 877-884. PMID 1373875  0.58
1991 Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC. A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes Molecular and Cellular Biology. 11: 1500-1507. PMID 1847500 DOI: 10.1128/Mcb.11.3.1500  0.637
1991 Perkins SL, Link DC, Kling S, Ley TJ, Teitelbaum SL. 1,25-Dihydroxyvitamin D3 induces monocytic differentiation of the PLB-985 leukemic line and promotes c-fgr mRNA expression Journal of Leukocyte Biology. 50: 427-433. PMID 1660912 DOI: 10.1002/Jlb.50.5.427  0.641
Show low-probability matches.