Moshe Oren - Publications

Affiliations: 
MCB Molecular Cell Biology Weizmann Institute of Science, Rehovot, Israel 
Area:
Molecular Biology

299 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hassin O, Sernik M, Seligman A, Vogel FCE, Wellenstein MD, Smollich J, Halperin C, Pirona AC, Toledano LN, Caballero CD, Schlicker L, Salame TM, Sarusi Portuguez A, Aylon Y, Scherz-Shouval R, ... ... Oren M, et al. p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells. Proceedings of the National Academy of Sciences of the United States of America. 120: e2311460120. PMID 38127986 DOI: 10.1073/pnas.2311460120  0.341
2022 Hassin O, Oren M. Drugging p53 in cancer: one protein, many targets. Nature Reviews. Drug Discovery. PMID 36216888 DOI: 10.1038/s41573-022-00571-8  0.383
2022 Mukherjee S, Maddalena M, Lü Y, Martinez S, Nataraj NB, Noronha A, Sinha S, Teng K, Cohen-Kaplan V, Ziv T, Arandkar S, Hassin O, Chatterjee R, Pirona AC, Shreberk-Shaked M, ... ... Oren M, et al. Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins. Proceedings of the National Academy of Sciences of the United States of America. 119: e2119644119. PMID 35439056 DOI: 10.1073/pnas.2119644119  0.471
2021 Maddalena M, Mallel G, Nataraj NB, Shreberk-Shaked M, Hassin O, Mukherjee S, Arandkar S, Rotkopf R, Kapsack A, Lambiase G, Pellegrino B, Ben-Isaac E, Golani O, Addadi Y, Hajaj E, ... ... Oren M, et al. missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34088837 DOI: 10.1073/pnas.2025631118  0.317
2020 Shaked MS, Dassa B, Sinha S, Di Agostino S, Azuri I, Mukherjee S, Aylon Y, Blandino G, Ruppin E, Oren M. A division of labor between YAP and TAZ in non-small cell lung cancer. Cancer Research. PMID 32816858 DOI: 10.1158/0008-5472.Can-20-0125  0.351
2020 Kadosh E, Snir-Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, Zinger A, Shaham M, Vaalani G, Mernberger M, Stiewe T, Pikarsky E, Oren M, Ben-Neriah Y. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic. Nature. PMID 32728212 DOI: 10.1038/S41586-020-2541-0  0.476
2020 Benor G, Fuks G, Chin SF, Rueda OM, Mukherjee S, Arandkar S, Aylon Y, Caldas C, Domany E, Oren M. Transcriptional profiling reveals a subset of human breast tumors that retain wt TP53 but display mutant p53-associated features. Molecular Oncology. PMID 32484602 DOI: 10.1002/1878-0261.12736  0.447
2020 Furth N, Pateras I, Rotkopf R, Schmitt I, Bakaev D, Gershoni A, Johnson R, Gorgoulis V, Oren M, Aylon Y. Abstract IA20: LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-Ia20  0.346
2020 Shreberk-Shaked M, Dassa B, Agostino SD, Nuriel Y, Wigoda N, Rotkopf R, Blandino G, Aylon Y, Oren M. Abstract B43: Division of labor between YAP and TAZ in lung cancer Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B43  0.326
2019 Oren M. p53: not just a tumor suppressor. Journal of Molecular Cell Biology. PMID 31291648 DOI: 10.1093/Jmcb/Mjz070  0.496
2019 Shreberk-Shaked M, Oren M. New insights into YAP/TAZ nucleo-cytoplasmic shuttling: New cancer therapeutic opportunities? Molecular Oncology. PMID 31050214 DOI: 10.1002/1878-0261.12498  0.305
2019 Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M, Rotter V. Retraction: Transactivation of the Gene Contributes to Mutant p53 Gain of Function. Cancer Research. 79: 2085. PMID 30987981 DOI: 10.1158/0008-5472.Can-19-0560  0.328
2019 Oren M, Arandkar S, Benor G, Furth N, Aylon Y, Domany E. Abstract SY32-02: Modulation of wild-type p53 activity in cancer cells and in the tumor microenvironment Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-Sy32-02  0.484
2019 Silverman DA, Ashkin E, Whitfield B, Punt S, Manrique SZ, Wang Y, Korkut A, Williams L, Zhang M, Kotler E, Oren M, Maitra A, Hwu P. Abstract 2372: Tumoral p53 mutations differentially mediate poor T-cell infiltration and autologous T-cell killing in preclinical models Immunology. DOI: 10.1158/1538-7445.Sabcs18-2372  0.391
2018 Furth N, Aylon Y, Oren M. p53 shades of Hippo. Cell Death and Differentiation. 25: 81-92. PMID 31745317 DOI: 10.1038/cdd.2017.163  0.443
2018 Hooda J, Novak M, Salomon MP, Matsuba C, Ramos RI, MacDuffie E, Song M, Hirsch MS, Lester J, Parkash V, Karlan BY, Oren M, Hoon DS, Drapkin R. Early loss of Histone H2B monoubiquitylation alters chromatin accessibility and activates key immune pathways that facilitate progression of ovarian cancer. Cancer Research. PMID 30563893 DOI: 10.1158/0008-5472.Can-18-2297  0.362
2018 Kotler E, Segal E, Oren M. Functional characterization of the p53 "mutome". Molecular & Cellular Oncology. 5: e1511207. PMID 30525089 DOI: 10.1080/23723556.2018.1511207  0.387
2018 Minzel W, Venkatachalam A, Fink A, Hung E, Brachya G, Burstain I, Shaham M, Rivlin A, Omer I, Zinger A, Elias S, Winter E, Erdman PE, Sullivan RW, Fung L, ... ... Oren M, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. PMID 30146162 DOI: 10.1016/J.Cell.2018.07.045  0.418
2018 Kotler E, Shani O, Goldfeld G, Lotan-Pompan M, Tarcic O, Gershoni A, Hopf TA, Marks DS, Oren M, Segal E. A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation. Molecular Cell. 71: 178-190.e8. PMID 29979965 DOI: 10.1016/J.Molcel.2018.06.012  0.445
2018 Arandkar S, Furth N, Elisha Y, Nataraj NB, van der Kuip H, Yarden Y, Aulitzky W, Ulitsky I, Geiger B, Oren M. Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features. Proceedings of the National Academy of Sciences of the United States of America. PMID 29866855 DOI: 10.1073/Pnas.1719076115  0.526
2018 Jethwa A, Słabicki M, Hüllein J, Jentzsch M, Dalal V, Rabe S, Wagner L, Walther T, Klapper W, Bohnenberger H, Rettel M, Lu J, Smits AH, Stein F, Savitski MM, ... ... Oren M, et al. TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma. Blood. PMID 29653964 DOI: 10.1182/Blood-2017-09-806679  0.536
2018 Ghannam-Shahbari D, Jacob E, Kakun RR, Wasserman T, Korsensky L, Sternfeld O, Kagan J, Bublik DR, Aviel-Ronen S, Levanon K, Sabo E, Larisch S, Oren M, Hershkovitz D, Perets R. PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma. Oncogene. PMID 29379162 DOI: 10.1038/S41388-017-0040-Z  0.512
2018 Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, et al. Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. Oncogene. PMID 29343849 DOI: 10.1038/S41388-017-0060-8  0.499
2017 Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, ... ... Oren M, et al. Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & Development. 31: 1926. PMID 29051390 DOI: 10.1101/gad.307207.117  0.721
2017 Enuka Y, Feldman ME, Chowdhury A, Srivastava S, Lindzen M, Sas-Chen A, Massart R, Cheishvili D, Suderman MJ, Zaltsman Y, Mazza CA, Shukla K, Körner C, Furth N, Lauriola M, ... Oren M, et al. Epigenetic mechanisms underlie the crosstalk between growth factors and a steroid hormone. Nucleic Acids Research. PMID 29036586 DOI: 10.1093/Nar/Gkx865  0.378
2017 Aylon Y, Oren M. Tumor Suppression by p53: Bring in the Hippo! Cancer Cell. 32: 397-399. PMID 29017051 DOI: 10.1016/J.Ccell.2017.09.010  0.517
2017 Furth N, Aylon Y, Oren M. p53 shades of Hippo. Cell Death and Differentiation. PMID 28984872 DOI: 10.1038/Cdd.2017.163  0.535
2017 Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Alton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes & Development. PMID 28607180 DOI: 10.1101/Gad.299198.117  0.451
2017 Spolverini A, Fuchs G, Bublik DR, Oren M. let-7b and let-7c microRNAs promote histone H2B ubiquitylation and inhibit cell migration by targeting multiple components of the H2B deubiquitylation machinery. Oncogene. PMID 28604753 DOI: 10.1038/Onc.2017.187  0.37
2017 Tarcic O, Granit RZ, Pateras IS, Masury H, Maly B, Zwang Y, Yarden Y, Gorgoulis VG, Pikarsky E, Ben-Porath I, Oren M. RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer. Cell Death and Differentiation. PMID 28157208 DOI: 10.1038/Cdd.2016.126  0.358
2017 Hood J, Novak M, MacDuffie E, Lester J, Parkash V, Mills GB, Karlan BY, Oren M, Drapkin R. Abstract MIP-060: EPIGENETIC DYSREGULATION OF A HISTONE MARK REVEALS A METABOLIC VULNERABILITY IN OVARIAN CANCER Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Mip-060  0.357
2016 Bublik DR, Bursać S, Sheffer M, Oršolić I, Shalit T, Tarcic O, Kotler E, Mouhadeb O, Hoffman Y, Fuchs G, Levin Y, Volarević S, Oren M. Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27994142 DOI: 10.1073/Pnas.1614876114  0.431
2016 Isaac R, Goldstein I, Furth N, Zilber N, Streim S, Boura-Halfon S, Elhanany E, Rotter V, Oren M, Zick Y. TM7SF3, a novel p53-regulated homeostatic factor, attenuates cellular stress and the subsequent induction of the unfolded protein response. Cell Death and Differentiation. PMID 27740623 DOI: 10.1038/Cdd.2016.108  0.519
2016 Oren M, Kotler E. p53 mutations promote proteasomal activity. Nature Cell Biology. 18: 833-5. PMID 27463250 DOI: 10.1038/Ncb3392  0.459
2016 Aylon Y, Oren M. The Hippo Pathway, p53 and Cholesterol. Cell Cycle (Georgetown, Tex.). 0. PMID 27419353 DOI: 10.1080/15384101.2016.1207840  0.447
2016 Aylon Y, Oren M. The Paradox of p53: What, How, and Why? Cold Spring Harbor Perspectives in Medicine. PMID 27413116 DOI: 10.1101/Cshperspect.A026328  0.554
2016 Simerzin A, Zorde-Khvalevsky E, Rivkin M, Adar R, Zucman-Rossi J, Couchy G, Roskams T, Govaere O, Oren M, Giladi H, Galun E. The liver-specific miR-122*, the complementary strand of miR-122, acts as a tumor suppressor by modulating the p53-Mdm2 circuitry. Hepatology (Baltimore, Md.). PMID 27302319 DOI: 10.1002/Hep.28679  0.371
2016 Aylon Y, Gershoni A, Rotkopf R, Biton IE, Porat Z, Koh AP, Sun X, Lee Y, Fiel MI, Hoshida Y, Friedman SL, Johnson RL, Oren M. The LATS2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation. Genes & Development. PMID 27013235 DOI: 10.1101/Gad.274167.115  0.345
2016 Tal P, Eizenberger S, Cohen E, Goldfinger N, Pietrokovski S, Oren M, Rotter V. Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides. Oncotarget. PMID 26943582 DOI: 10.18632/Oncotarget.7857  0.481
2016 Hoffman Y, Bublik DR, P Ugalde A, Elkon R, Biniashvili T, Agami R, Oren M, Pilpel Y. 3'UTR Shortening Potentiates MicroRNA-Based Repression of Pro-differentiation Genes in Proliferating Human Cells. Plos Genetics. 12: e1005879. PMID 26908102 DOI: 10.1371/Journal.Pgen.1005879  0.335
2016 Tarcic O, Pateras IS, Cooks T, Shema E, Kanterman J, Ashkenazi H, Boocholez H, Hubert A, Rotkopf R, Baniyash M, Pikarsky E, Gorgoulis VG, Oren M. RNF20 Links Histone H2B Ubiquitylation with Inflammation and Inflammation-Associated Cancer. Cell Reports. PMID 26854224 DOI: 10.1016/J.Celrep.2016.01.020  0.396
2016 Oren M, Furth N, Ben-Moshe NB, Porat Z, Domany E, Pozniak Y, Geiger T, Aylon Y. Abstract SY26-03: Tumor suppressor crosstalk: Modulation of p53 activity by the Hippo pathway Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Sy26-03  0.609
2016 Furth N, Bossel N, Pozniak Y, Geiger T, Domany E, Aylon Y, Oren M. Tumor suppressor crosstalk: Hippo and p53 European Journal of Cancer. 61: S50. DOI: 10.1016/S0959-8049(16)61166-8  0.497
2015 Orsolic I, Jurada D, Pullen N, Oren M, Eliopoulos AG, Volarevic S. The relationship between the nucleolus and cancer: Current evidence and emerging paradigms. Seminars in Cancer Biology. PMID 26721423 DOI: 10.1016/J.Semcancer.2015.12.004  0.407
2015 Furth N, Bossel Ben-Moshe N, Pozniak Y, Porat Z, Geiger T, Domany E, Aylon Y, Oren M. Down-regulation of LATS kinases alters p53 to promote cell migration. Genes & Development. 29: 2325-30. PMID 26588988 DOI: 10.1101/Gad.268185.115  0.575
2015 Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Martinez Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. Retraction notice to "Regulation of p53: Intricate loops and delicate balances" [Biochem. Pharmacol. 64 (2002) 865-871]. Biochemical Pharmacology. 96: 369. PMID 26465018 DOI: 10.1016/J.Bcp.2015.07.001  0.503
2015 Blume CJ, Hotz-Wagenblatt A, Hüllein J, Sellner L, Jethwa A, Stolz T, Slabicki M, Lee K, Sharathchandra A, Benner A, Dietrich S, Oakes CC, Dreger P, Te Raa D, Kater AP, ... ... Oren M, et al. p53-dependent non-coding RNA networks in Chronic Lymphocytic Leukemia. Leukemia. PMID 25971364 DOI: 10.1038/Leu.2015.119  0.506
2015 Adi Harel S, Bossel Ben-Moshe N, Aylon Y, Bublik DR, Moskovits N, Toperoff G, Azaiza D, Biagoni F, Fuchs G, Wilder S, Hellman A, Blandino G, Domany E, Oren M. Reactivation of epigenetically silenced miR-512 and miR-373 sensitizes lung cancer cells to cisplatin and restricts tumor growth. Cell Death and Differentiation. 22: 1328-40. PMID 25591738 DOI: 10.1038/Cdd.2014.221  0.702
2014 Weilbacher A, Gutekunst M, Oren M, Aulitzky WE, Kuip Hvd. RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38. Cell Death and Disease. 5. PMID 25010984 DOI: 10.1038/Cddis.2014.284  0.582
2014 Cooks T, Harris CC, Oren M. Caught in the cross fire: p53 in inflammation. Carcinogenesis. 35: 1680-90. PMID 24942866 DOI: 10.1093/Carcin/Bgu134  0.542
2014 Hoffman Y, Pilpel Y, Oren M. microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network. Journal of Molecular Cell Biology. 6: 192-7. PMID 24868102 DOI: 10.1093/Jmcb/Mju020  0.452
2014 Golomb L, Volarevic S, Oren M. p53 and ribosome biogenesis stress: the essentials. Febs Letters. 588: 2571-9. PMID 24747423 DOI: 10.1016/J.Febslet.2014.04.014  0.419
2014 Aylon Y, Sarver A, Tovy A, Ainbinder E, Oren M. Lats2 is critical for the pluripotency and proper differentiation of stem cells. Cell Death and Differentiation. 21: 624-33. PMID 24413153 DOI: 10.1038/Cdd.2013.188  0.364
2014 Fuchs G, Oren M. Writing and reading H2B monoubiquitylation. Biochimica Et Biophysica Acta. 1839: 694-701. PMID 24412854 DOI: 10.1016/J.Bbagrm.2014.01.002  0.303
2014 Hoffman Y, Bublik DR, Pilpel Y, Oren M. MiR-661 downregulates both Mdm2 and Mdm4 to activate p53 Cell Death and Differentiation. 21: 302-309. PMID 24141721 DOI: 10.1038/Cdd.2013.146  0.418
2014 Weingarten-Gabbay S, Khan D, Liberman N, Yoffe Y, Bialik S, Das S, Oren M, Kimchi A. The translation initiation factor DAP5 promotes IRES-driven translation of p53 mRNA Oncogene. 33: 611-618. PMID 23318444 DOI: 10.1038/Onc.2012.626  0.475
2014 Shapira S, Shapira A, Kazanov D, Kraus S, Oren M, Arber N. 873 The “Trojan Horse” Strategy: Selective Eradication of Cancer Cells by Adenovirus-Based Delivery of Cytotoxic Agents: An Alternative Method for Targeting Pancreatic (PC) and Colorectal Cancers (CRC) Gastroenterology. 146. DOI: 10.1016/S0016-5085(14)60540-0  0.355
2014 Lasry A, Aran D, Zinger A, Hamza H, Kadosh E, Elyada E, Pribluda A, Hellman A, Oren M, Pikarsky E, Ben-Neriah Y. S-6 Cytokine. 70: 22. DOI: 10.1016/J.Cyto.2014.07.226  0.366
2013 Golomb L, Oren M. In the race for protection, ARF comes second Cell Death and Differentiation. 20: 1442-1443. PMID 24096933 DOI: 10.1038/Cdd.2013.117  0.518
2013 Fausti F, Di Agostino S, Cioce M, Bielli P, Sette C, Pandolfi PP, Oren M, Sudol M, Strano S, Blandino G. ATM kinase enables the functional axis of YAP, PML and p53 to ameliorate loss of Werner protein-mediated oncogenic senescence. Cell Death and Differentiation. 20: 1498-509. PMID 23933816 DOI: 10.1038/Cdd.2013.101  0.482
2013 Shema-Yaacoby E, Nikolov M, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W. Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription. Cell Reports. 4: 601-8. PMID 23933260 DOI: 10.1016/J.Celrep.2013.07.014  0.353
2013 Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, ... ... Oren M, et al. A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell. 24: 242-56. PMID 23890787 DOI: 10.1016/J.Ccr.2013.06.005  0.415
2013 Suzuki H, Yabuta N, Okada N, Torigata K, Aylon Y, Oren M, Nojima H. Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis. Journal of Cell Science. 126: 4358-68. PMID 23886938 DOI: 10.1242/Jcs.125815  0.44
2013 Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, ... ... Oren M, et al. Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell. 23: 634-46. PMID 23680148 DOI: 10.1016/J.Ccr.2013.03.022  0.441
2013 Gutekunst M, Mueller T, Weilbacher A, Dengler MA, Bedke J, Kruck S, Oren M, Aulitzky WE, van der Kuip H. Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4. Cancer Research. 73: 1460-9. PMID 23302226 DOI: 10.1158/0008-5472.Can-12-2876  0.536
2013 Gutekunst M, Mueller T, Weilbacher A, Dengler MA, Oren M, Aulitzky WE, Kuip Hvd. Abstract 1721: Testicular germ cell tumors are hypersensitive to p53 activation based on their Oct-4/Noxa-mediated cellular context rather than on differential p53 activity. Cancer Research. 73: 1721-1721. DOI: 10.1158/1538-7445.Am2013-1721  0.588
2012 Bursać S, Brdovčak MC, Pfannkuchen M, Orsolić I, Golomb L, Zhu Y, Katz C, Daftuar L, Grabušić K, Vukelić I, Filić V, Oren M, Prives C, Volarevic S. Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress. Proceedings of the National Academy of Sciences of the United States of America. 109: 20467-72. PMID 23169665 DOI: 10.1073/Pnas.1218535109  0.347
2012 Schmid JO, Dong M, Haubeiss S, Friedel G, Bode S, Grabner A, Ott G, Mürdter TE, Oren M, Aulitzky WE, van der Kuip H. Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin. Cancer Research. 72: 5824-32. PMID 22962266 DOI: 10.1158/0008-5472.Can-12-1201  0.524
2012 Fuchs G, Shema E, Vesterman R, Kotler E, Wolchinsky Z, Wilder S, Golomb L, Pribluda A, Zhang F, Haj-Yahya M, Feldmesser E, Brik A, Yu X, Hanna J, Aberdam D, ... ... Oren M, et al. RNF20 and USP44 regulate stem cell differentiation by modulating H2B monoubiquitylation. Molecular Cell. 46: 662-73. PMID 22681888 DOI: 10.1016/J.Molcel.2012.05.023  0.312
2012 Hornung G, Oren M, Barkai N. Nucleosome organization affects the sensitivity of gene expression to promoter mutations. Molecular Cell. 46: 362-8. PMID 22464732 DOI: 10.1016/J.Molcel.2012.02.019  0.319
2012 Bublik DR, Oren M. Get your fingers out of p53's way! Embo Reports. 13: 282-3. PMID 22422000 DOI: 10.1038/Embor.2012.33  0.521
2012 Zwang Y, Oren M, Yarden Y. Consistency test of the cell cycle: roles for p53 and EGR1. Cancer Research. 72: 1051-4. PMID 22315347 DOI: 10.1158/0008-5472.Can-11-3382  0.456
2012 Golomb L, Bublik DR, Wilder S, Nevo R, Kiss V, Grabusic K, Volarevic S, Oren M. Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis. Molecular Cell. 45: 222-32. PMID 22284678 DOI: 10.1016/J.Molcel.2011.11.022  0.524
2012 Schmid JO, Dong M, Haubeiss S, Friedel G, Oren M, Mürdter TE, Aulitzky WE, Kuip Hvd. Abstract 2869: p53 response of cancer associated fibroblasts (CAFs) to cisplatin is closely correlated with the p53 response of tumor cells in lung cancer tissue cultures Cancer Research. 72: 2869-2869. DOI: 10.1158/1538-7445.Am2012-2869  0.544
2011 Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M, Rotter V, Wiman K, Oren M. Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death and Differentiation. 19: 180-3. PMID 22095277 DOI: 10.1038/Cdd.2011.148  0.486
2011 Golomb L, Oren M. DePICTing p53 activation: a new nucleolar link to cancer. Cancer Cell. 20: 283-4. PMID 21907918 DOI: 10.1016/J.Ccr.2011.08.017  0.533
2011 Aylon Y, Oren M. p53: guardian of ploidy. Molecular Oncology. 5: 315-23. PMID 21852209 DOI: 10.1016/J.Molonc.2011.07.007  0.515
2011 Shiloh Y, Shema E, Moyal L, Oren M. RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response. Febs Letters. 585: 2795-802. PMID 21827756 DOI: 10.1016/J.Febslet.2011.07.034  0.379
2011 Rivlin N, Brosh R, Oren M, Rotter V. Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis. Genes & Cancer. 2: 466-74. PMID 21779514 DOI: 10.1177/1947601911408889  0.539
2011 Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, Lu Y, Mills GB, Rechavi G, Oren M, Domany E, et al. Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Molecular Cell. 42: 524-35. PMID 21596316 DOI: 10.1016/J.Molcel.2011.04.017  0.344
2011 Shema E, Kim J, Roeder RG, Oren M. RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Molecular Cell. 42: 477-88. PMID 21596312 DOI: 10.1016/J.Molcel.2011.03.011  0.375
2011 Tarocchi M, Hannivoort R, Hoshida Y, Lee UE, Vetter D, Narla G, Villanueva A, Oren M, Llovet JM, Friedman SL. Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation. Hepatology (Baltimore, Md.). 54: 522-31. PMID 21563203 DOI: 10.1002/Hep.24413  0.397
2011 Gutekunst M, Oren M, Weilbacher A, Dengler MA, Markwardt C, Thomale J, Aulitzky WE, van der Kuip H. p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. Plos One. 6: e19198. PMID 21532991 DOI: 10.1371/Journal.Pone.0019198  0.573
2011 Shema E, Oren M, Minsky N. Detection and characterization of ubiquitylated H2B in mammalian cells. Methods (San Diego, Calif.). 54: 326-30. PMID 21439383 DOI: 10.1016/J.Ymeth.2011.03.005  0.339
2011 Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, ... ... Oren M, et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Molecular Cell. 41: 529-42. PMID 21362549 DOI: 10.1016/J.Molcel.2011.02.015  0.301
2011 Dell'Orso S, Fontemaggi G, Stambolsky P, Goeman F, Voellenkle C, Levrero M, Strano S, Rotter V, Oren M, Blandino G. ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters. Omics : a Journal of Integrative Biology. 15: 305-12. PMID 21332394 DOI: 10.1089/Omi.2010.0084  0.551
2011 Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y. CKIα ablation highlights a critical role for p53 in invasiveness control. Nature. 470: 409-13. PMID 21331045 DOI: 10.1038/Nature09673  0.532
2011 Aylon Y, Oren M. New plays in the p53 theater. Current Opinion in Genetics & Development. 21: 86-92. PMID 21317061 DOI: 10.1016/J.Gde.2010.10.002  0.564
2011 Okada N, Yabuta N, Suzuki H, Aylon Y, Oren M, Nojima H. A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. Journal of Cell Science. 124: 57-67. PMID 21118956 DOI: 10.1242/Jcs.072918  0.458
2011 Goldstein I, Marcel V, Olivier M, Oren M, Rotter V, Hainaut P. Understanding wild-type and mutant p53 activities in human cancer: New landmarks on the way to targeted therapies Cancer Gene Therapy. 18: 2-11. PMID 20966976 DOI: 10.1038/Cgt.2010.63  0.544
2011 Gutekunst M, Oren M, Weilbacher A, Dengler MA, Aulitzky WE, Kuip Hvd. Abstract 4693: High expression levels of NOXA are important for p53-mediated hypersensitivity in testicular germ cell tumor (TGCT) cells Cancer Research. 71: 4693-4693. DOI: 10.1158/1538-7445.Am2011-4693  0.562
2011 Oren M, Aylon Y, Shema E, Fuchs G. 229 INVITED Tumour Suppressor Networks: Lessons From p53 European Journal of Cancer. 47: S54-S55. DOI: 10.1016/S0959-8049(11)70444-0  0.379
2010 Aylon Y, Ofir-Rosenfeld Y, Yabuta N, Lapi E, Nojima H, Lu X, Oren M. The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1. Genes & Development. 24: 2420-9. PMID 21041410 DOI: 10.1101/Gad.1954410  0.822
2010 Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M. p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner Cancer Research. 70: 9650-9658. PMID 20952507 DOI: 10.1158/0008-5472.Can-10-1146  0.798
2010 Scherz-Shouval R, Weidberg H, Gonen C, Wilder S, Elazar Z, Oren M. p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proceedings of the National Academy of Sciences of the United States of America. 107: 18511-6. PMID 20937856 DOI: 10.1073/Pnas.1006124107  0.575
2010 Lidor Nili E, Field Y, Lubling Y, Widom J, Oren M, Segal E. p53 binds preferentially to genomic regions with high DNA-encoded nucleosome occupancy. Genome Research. 20: 1361-8. PMID 20716666 DOI: 10.1101/Gr.103945.109  0.747
2010 Oren M, Cooks T. NFκB and p53: A life and death affair. Cell Cycle (Georgetown, Tex.). 9: 1027. PMID 20237416 DOI: 10.4161/Cc.9.6.11099  0.389
2010 Schilling T, Kairat A, Melino G, Krammer PH, Stremmel W, Oren M, Müller M. Interference with the p53 family network contributes to the gain of oncogenic function of mutant p53 in hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 394: 817-23. PMID 20233581 DOI: 10.1016/J.Bbrc.2010.03.082  0.535
2010 Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, Sigfried Z, Shiff I, Kogan I, Shay M, Kalo E, Blandino G, Simon I, Oren M, Rotter V. Modulation of the vitamin D3 response by cancer-associated mutant p53. Cancer Cell. 17: 273-85. PMID 20227041 DOI: 10.1016/J.Ccr.2009.11.025  0.457
2010 Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harbor Perspectives in Biology. 2: a001107. PMID 20182618 DOI: 10.1101/Cshperspect.A001107  0.533
2010 Bar J, Moskovits N, Oren M. Involvement of stromal p53 in tumor-stroma interactions. Seminars in Cell & Developmental Biology. 21: 47-54. PMID 19914385 DOI: 10.1016/J.Semcdb.2009.11.006  0.811
2010 Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death and Differentiation. 17: 236-45. PMID 19696787 DOI: 10.1038/Cdd.2009.109  0.314
2010 Stambolsky P, Tabach Y, Fontemaggi G, Weisz L, Maor-Aloni R, Siegfried Z, Shiff I, Kogan I, Shay M, Kalo E, Blandino G, Simon I, Oren M, Rotter V. Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53 (DOI:10.1016/j.ccr.2009.11.025) Cancer Cell. 17: 523. DOI: 10.1016/J.Ccr.2010.04.017  0.356
2009 Lavelin I, Beer A, Kam Z, Rotter V, Oren M, Navon A, Geiger B. Discovery of novel proteasome inhibitors using a high-content cell-based screening system. Plos One. 4: e8503. PMID 20041034 DOI: 10.1371/Journal.Pone.0008503  0.383
2009 Skorta I, Oren M, Markwardt C, Gutekunst M, Aulitzky WE, van der Kuip H. Imatinib mesylate induces cisplatin hypersensitivity in Bcr-Abl+ cells by differential modulation of p53 transcriptional and proapoptotic activity. Cancer Research. 69: 9337-45. PMID 19934315 DOI: 10.1158/0008-5472.Can-09-0548  0.497
2009 Aylon Y, Yabuta N, Besserglick H, Buganim Y, Rotter V, Nojima H, Oren M. Silencing of the lats2 tumor suppressor overrides a p53-dependent oncogenic stress checkpoint and enables mutant H-Ras-driven cell transformation Oncogene. 28: 4469-4479. PMID 19855428 DOI: 10.1038/Onc.2009.270  0.463
2009 Levine AJ, Oren M. The first 30 years of p53: growing ever more complex. Nature Reviews. Cancer. 9: 749-58. PMID 19776744 DOI: 10.1038/Nrc2723  0.521
2009 Schilling T, Schleithoff ES, Kairat A, Melino G, Stremmel W, Oren M, Krammer PH, Müller M. Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family. Biochemical and Biophysical Research Communications. 387: 399-404. PMID 19615968 DOI: 10.1016/J.Bbrc.2009.07.063  0.497
2009 Pirngruber J, Shchebet A, Schreiber L, Shema E, Minsky N, Chapman RD, Eick D, Aylon Y, Oren M, Johnsen SA. CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing. Embo Reports. 10: 894-900. PMID 19575011 DOI: 10.1038/Embor.2009.108  0.323
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, ... ... Oren M, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/Cdd.2009.44  0.303
2009 Bar J, Feniger-Barish R, Lukashchuk N, Shaham H, Moskovits N, Goldfinger N, Simansky D, Perlman M, Papa M, Yosepovich A, Rechavi G, Rotter V, Oren M. Cancer cells suppress p53 in adjacent fibroblasts. Oncogene. 28: 933-6. PMID 19060923 DOI: 10.1038/Onc.2008.445  0.809
2008 Brosh R, Shalgi R, Liran A, Landan G, Korotayev K, Nguyen GH, Enerly E, Johnsen H, Buganim Y, Solomon H, Goldstein I, Madar S, Goldfinger N, Børresen-Dale AL, Ginsberg D, ... ... Oren M, et al. p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation. Molecular Systems Biology. 4: 229. PMID 19034270 DOI: 10.1038/Msb.2008.65  0.351
2008 Ofir-Rosenfeld Y, Boggs K, Michael D, Kastan MB, Oren M. Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26. Molecular Cell. 32: 180-9. PMID 18951086 DOI: 10.1016/J.Molcel.2008.08.031  0.802
2008 Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, ... ... Oren M, et al. The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression. Genes & Development. 22: 2664-76. PMID 18832071 DOI: 10.1101/Gad.1703008  0.757
2008 Bossi G, Marampon F, Maor-Aloni R, Zani B, Rotter V, Oren M, Strano S, Blandino G, Sacchi A. Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy. Cell Cycle (Georgetown, Tex.). 7: 1870-9. PMID 18594199 DOI: 10.4161/Cc.7.12.6161  0.528
2008 Finkin S, Aylon Y, Anzi S, Oren M, Shaulian E. Fbw7 regulates the activity of endoreduplication mediators and the p53 pathway to prevent drug-induced polyploidy. Oncogene. 27: 4411-4421. PMID 18391985 DOI: 10.1038/Onc.2008.77  0.53
2008 Abe Y, Oda-Sato E, Tobiume K, Kawauchi K, Taya Y, Okamoto K, Oren M, Tanaka N. Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2. Proceedings of the National Academy of Sciences of the United States of America. 105: 4838-43. PMID 18359851 DOI: 10.1073/Pnas.0712216105  0.518
2008 Minsky N, Shema E, Field Y, Schuster M, Segal E, Oren M. Monoubiquitinated H2B is associated with the transcribed region of highly expressed genes in human cells. Nature Cell Biology. 10: 483-8. PMID 18344985 DOI: 10.1038/Ncb1712  0.396
2007 Raver-Shapira N, Oren M. Tiny actors, great roles: microRNAs in p53's service. Cell Cycle (Georgetown, Tex.). 6: 2656-61. PMID 17957137 DOI: 10.4161/Cc.6.21.4915  0.407
2007 Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 12: 342-54. PMID 17936559 DOI: 10.1016/J.Ccr.2007.08.033  0.576
2007 Lantner F, Starlets D, Gore Y, Flaishon L, Yamit-Hezi A, Dikstein R, Leng L, Bucala R, Machluf Y, Oren M, Shachar I. CD74 induces TAp63 expression leading to B-cell survival. Blood. 110: 4303-11. PMID 17846227 DOI: 10.1182/Blood-2007-04-087486  0.34
2007 Aylon Y, Oren M. Living with p53, dying of p53. Cell. 130: 597-600. PMID 17719538 DOI: 10.1016/J.Cell.2007.08.005  0.466
2007 Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G. The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proceedings of the National Academy of Sciences of the United States of America. 104: 11280-5. PMID 17592138 DOI: 10.1073/Pnas.0701773104  0.443
2007 Raver-Shapira N, Marciano E, Meiri E, Spector Y, Rosenfeld N, Moskovits N, Bentwich Z, Oren M. Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Molecular Cell. 26: 731-43. PMID 17540598 DOI: 10.1016/J.Molcel.2007.05.017  0.744
2007 Reef S, Shifman O, Oren M, Kimchi A. The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein. Oncogene. 26: 6677-83. PMID 17486078 DOI: 10.1038/Sj.Onc.1210485  0.46
2007 Weisz L, Oren M, Rotter V. Transcription regulation by mutant p53 Oncogene. 26: 2202-2211. PMID 17401429 DOI: 10.1038/Sj.Onc.1210294  0.562
2007 Shmueli A, Oren M. Mdm2: p53's lifesaver? Molecular Cell. 25: 794-6. PMID 17386256 DOI: 10.1016/J.Molcel.2007.03.006  0.642
2007 Weisz L, Damalas A, Liontos M, Karakaidos P, Fontemaggi G, Maor-Aloni R, Kalis M, Levrero M, Strano S, Gorgoulis VG, Rotter V, Blandino G, Oren M. Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells. Cancer Research. 67: 2396-401. PMID 17363555 DOI: 10.1158/0008-5472.Can-06-2425  0.523
2007 Oren M, Bartek J. The sunny side of p53. Cell. 128: 826-8. PMID 17350568 DOI: 10.1016/J.Cell.2007.02.027  0.394
2007 Skorta I, van der Kuip H, Henkes M, Oren M, Aulitzky WE. Combination of Imatinib with Cisplatin and Nutlin-3: Functional and Molecular Effects on Bcr-Abl Positive Cells. Blood. 110: 2954-2954. DOI: 10.1182/Blood.V110.11.2954.2954  0.496
2006 Moskovits N, Kalinkovich A, Bar J, Lapidot T, Oren M. p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Research. 66: 10671-6. PMID 17108103 DOI: 10.1158/0008-5472.Can-06-2323  0.803
2006 Aylon Y, Michael D, Shmueli A, Yabuta N, Nojima H, Oren M. A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization. Genes & Development. 20: 2687-700. PMID 17015431 DOI: 10.1101/Gad.1447006  0.743
2006 Stambolsky P, Weisz L, Shats I, Klein Y, Goldfinger N, Oren M, Rotter V. Regulation of AIF expression by p53. Cell Death and Differentiation. 13: 2140-9. PMID 16729031 DOI: 10.1038/Sj.Cdd.4401965  0.56
2006 Reef S, Zalckvar E, Shifman O, Bialik S, Sabanay H, Oren M, Kimchi A. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Molecular Cell. 22: 463-75. PMID 16713577 DOI: 10.1016/J.Molcel.2006.04.014  0.454
2006 Avkin S, Sevilya Z, Toube L, Geacintov N, Chaney SG, Oren M, Livneh Z. p53 and p21 regulate error-prone DNA repair to yield a lower mutation load. Molecular Cell. 22: 407-13. PMID 16678112 DOI: 10.1016/J.Molcel.2006.03.022  0.479
2006 Margalit O, Amram H, Amariglio N, Simon AJ, Shaklai S, Granot G, Minsky N, Shimoni A, Harmelin A, Givol D, Shohat M, Oren M, Rechavi G. BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma. Blood. 107: 1599-607. PMID 16249378 DOI: 10.1182/Blood-2005-04-1629  0.539
2006 Zalcenstein A, Weisz L, Stambolsky P, Bar J, Rotter V, Oren M. Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53. Oncogene. 25: 359-69. PMID 16170349 DOI: 10.1038/Sj.Onc.1209061  0.52
2006 Oren M. 234 INVITED Tumor suppression by p53: inside and outside the cancer cell European Journal of Cancer Supplements. 4: 76. DOI: 10.1016/S1359-6349(06)70239-7  0.413
2005 Müller M, Schilling T, Sayan AE, Kairat A, Lorenz K, Schulze-Bergkamen H, Oren M, Koch A, Tannapfel A, Stremmel W, Melino G, Krammer PH. TAp73/ΔNp73 influences apoptotic response, chemosensitivity and prognosis in hepatocellular carcinoma Cell Death & Differentiation. 12: 1564-1577. PMID 16195739 DOI: 10.1038/Sj.Cdd.4401774  0.428
2005 Shmueli A, Oren M. Life, death, and ubiquitin: taming the mule. Cell. 121: 963-5. PMID 15989944 DOI: 10.1016/J.Cell.2005.06.018  0.637
2005 Gressner O, Schilling T, Lorenz K, Schulze Schleithoff E, Koch A, Schulze-Bergkamen H, Lena AM, Candi E, Terrinoni A, Catani MV, Oren M, Melino G, Krammer PH, Stremmel W, Müller M. TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. The Embo Journal. 24: 2458-71. PMID 15944736 DOI: 10.1038/Sj.Emboj.7600708  0.404
2005 Bar J, Lukaschuk N, Zalcenstein A, Wilder S, Seger R, Oren M. The PI3K inhibitor LY294002 prevents p53 induction by DNA damage and attenuates chemotherapy-induced apoptosis. Cell Death and Differentiation. 12: 1578-87. PMID 15933740 DOI: 10.1038/Sj.Cdd.4401677  0.491
2005 Oberst A, Rossi M, Salomoni P, Pandolfi PP, Oren M, Melino G, Bernassola F. Regulation of the p73 protein stability and degradation. Biochemical and Biophysical Research Communications. 331: 707-12. PMID 15865926 DOI: 10.1016/J.Bbrc.2005.03.158  0.586
2005 Hershko T, Chaussepied M, Oren M, Ginsberg D. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death & Differentiation. 12: 377-383. PMID 15706352 DOI: 10.1038/Sj.Cdd.4401575  0.532
2005 Wohlbold L, van der Kuip H, Moehring A, Granot G, Oren M, Vornlocher HP, Aulitzky WE. All common p210 and p190 Bcr-abl variants can be targeted by RNA interference. Leukemia. 19: 290-2. PMID 15565163 DOI: 10.1038/Sj.Leu.2403603  0.438
2005 Damalas A, Weis L, Nordgard S, Kristensen V, Gardner K, Cheng G, Gelinas C, Levrero M, Strano S, Børresen-Dale A, Rotter V, Oren M, Blandino G. Mutant p53 exerts its gain of function through activation of the NF-κB pathway Breast Cancer Research. 7. DOI: 10.1186/Bcr1176  0.513
2004 Weisz L, Zalcenstein A, Stambolsky P, Cohen Y, Goldfinger N, Oren M, Rotter V. Transactivation of the EGR1 gene contributes to mutant p53 gain of function. Cancer Research. 64: 8318-27. PMID 15548700 DOI: 10.1158/0008-5472.Can-04-1145  0.568
2004 Minsky N, Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Molecular Cell. 16: 631-9. PMID 15546622 DOI: 10.1016/J.Molcel.2004.10.016  0.468
2004 Daniely Y, Liao G, Dixon D, Linnoila RI, Lori A, Randell SH, Oren M, Jetten AM. Critical role of p63 in the development of a normal esophageal and tracheobronchial epithelium. American Journal of Physiology. Cell Physiology. 287: C171-81. PMID 15189821 DOI: 10.1152/Ajpcell.00226.2003  0.357
2004 Levina E, Oren M, Ben-Ze'ev A. Downregulation of beta-catenin by p53 involves changes in the rate of beta-catenin phosphorylation and Axin dynamics. Oncogene. 23: 4444-53. PMID 15064706 DOI: 10.1038/Sj.Onc.1207587  0.324
2004 Wang X, Taplick J, Geva N, Oren M. Inhibition of p53 degradation by Mdm2 acetylation. Febs Letters. 561: 195-201. PMID 15013777 DOI: 10.1016/S0014-5793(04)00168-1  0.561
2004 Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Géant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A. Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter. Proceedings of the National Academy of Sciences of the United States of America. 101: 3510-5. PMID 14985507 DOI: 10.1073/Pnas.0400177101  0.507
2004 Bar J, Cohen-Noyman E, Geiger B, Oren M. Attenuation of the p53 response to DNA damage by high cell density. Oncogene. 23: 2128-37. PMID 14755247 DOI: 10.1038/Sj.Onc.1207325  0.528
2004 Shmueli A, Oren M. Regulation of p53 by Mdm2: fate is in the numbers. Molecular Cell. 13: 4-5. PMID 14731389 DOI: 10.1016/S1097-2765(03)00529-X  0.756
2004 Wohlbold L, van der Kuip H, Moehring A, Granot G, Oren M, Vornlocher H, Aulitzky WE. Repeated Application of Sequence-Specific SiRNA Molecules Leads to an Effective Downmodulation of All Clinically Relevant bcr-abl Gene Variants. Blood. 104: 4319-4319. DOI: 10.1182/Blood.V104.11.4319.4319  0.343
2003 Zalcenstein A, Stambolsky P, Weisz L, Müller M, Wallach D, Goncharov TM, Krammer PH, Rotter V, Oren M. Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants. Oncogene. 22: 5667-76. PMID 12944915 DOI: 10.1038/Sj.Onc.1206724  0.482
2003 Wang X, Zalcenstein A, Oren M. Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation Cell Death and Differentiation. 10: 468-476. PMID 12719724 DOI: 10.1038/Sj.Cdd.4401181  0.56
2003 Oren M. Decision making by p53: Life, death and cancer Cell Death and Differentiation. 10: 431-442. PMID 12719720 DOI: 10.1038/Sj.Cdd.4401183  0.578
2003 Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, et al. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proceedings of the National Academy of Sciences of the United States of America. 100: 2284-9. PMID 12606722 DOI: 10.1073/Pnas.0530298100  0.537
2003 Lavon I, Pikarsky E, Gutkovich E, Goldberg I, Bar J, Oren M, Ben-Neriah Y. Nuclear factor-kappaB protects the liver against genotoxic stress and functions independently of p53. Cancer Research. 63: 25-30. PMID 12517772  0.307
2003 Ofek P, Ben-Meir D, Kariv-Inbal Z, Oren M, Lavi S. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of Biological Chemistry. 278: 14299-305. PMID 12514180 DOI: 10.1074/Jbc.M211699200  0.579
2003 Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Seminars in Cancer Biology. 13: 49-58. PMID 12507556 DOI: 10.1016/S1044-579X(02)00099-8  0.539
2002 Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'Ev A. Regulation of p53: intricate loops and delicate balances. Annals of the New York Academy of Sciences. 973: 374-83. PMID 12485897 DOI: 10.1111/J.1749-6632.2002.Tb04669.X  0.559
2002 Blander G, Zalle N, Daniely Y, Taplick J, Gray MD, Oren M. DNA damage-induced translocation of the Werner helicase is regulated by acetylation. The Journal of Biological Chemistry. 277: 50934-40. PMID 12384494 DOI: 10.1074/Jbc.M210479200  0.408
2002 Balass M, Kalef E, Maya R, Wilder S, Oren M, Katchalski-Katzir E. Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation. Peptides. 23: 1719-25. PMID 12383858 DOI: 10.1016/S0196-9781(02)00147-X  0.33
2002 Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U, Oren M, Hainaut P. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene. 21: 6722-8. PMID 12360399 DOI: 10.1038/Sj.Onc.1205874  0.582
2002 Oren M, Damalas A, Gottlieb T, Michael D, Taplick J, Leal JF, Maya R, Moas M, Seger R, Taya Y, Ben-Ze'ev A. Regulation of p53: intricate loops and delicate balances. Biochemical Pharmacology. 64: 865-71. PMID 12213580 DOI: 10.1016/S0006-2952(02)01149-8  0.558
2002 Goldberg Z, Vogt Sionov R, Berger M, Zwang Y, Perets R, Van Etten RA, Oren M, Taya Y, Haupt Y. Tyrosine phosphorylation of Mdm2 by c-Abl: implications for p53 regulation. The Embo Journal. 21: 3715-27. PMID 12110584 DOI: 10.1093/Emboj/Cdf384  0.491
2002 Folberg-Blum A, Sapir A, Shilo BZ, Oren M. Overexpression of mouse Mdm2 induces developmental phenotypes in Drosophila. Oncogene. 21: 2413-7. PMID 11948425 DOI: 10.1038/Sj.Onc.1205305  0.5
2002 Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Monti O, Baccarini A, Del Sal G, Levrero M, Sacchi A, Oren M, Blandino G. Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. The Journal of Biological Chemistry. 277: 18817-26. PMID 11893750 DOI: 10.1074/Jbc.M201405200  0.596
2002 Wang X, Michael D, de Murcia G, Oren M. p53 Activation by nitric oxide involves down-regulation of Mdm2. The Journal of Biological Chemistry. 277: 15697-702. PMID 11867628 DOI: 10.1074/Jbc.M112068200  0.575
2002 Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. 21: 1299-303. PMID 11850850 DOI: 10.1038/Sj.Onc.1205181  0.498
2002 Michael D, Oren M. The p53 and Mdm2 families in cancer. Current Opinion in Genetics & Development. 12: 53-9. PMID 11790555 DOI: 10.1016/S0959-437X(01)00264-7  0.436
2001 Oren M. The p53 saga: the good, the bad, and the dead Harvey Lectures. 97: 57-82. PMID 14562517  0.408
2001 Susini L, Passer BJ, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron MC, Israël A, Amson R, Oren M, Telerman A. Siah-1 binds and regulates the function of Numb. Proceedings of the National Academy of Sciences of the United States of America. 98: 15067-72. PMID 11752454 DOI: 10.1073/Pnas.261571998  0.42
2001 Sadot E, Geiger B, Oren M, Ben-Ze'ev A. Down-regulation of beta-catenin by activated p53. Molecular and Cellular Biology. 21: 6768-81. PMID 11564862 DOI: 10.1128/Mcb.21.20.6768-6781.2001  0.371
2001 Damalas A, Kahan S, Shtutman M, Ben‐Ze'ev A, Oren M. Deregulated β‐catenin induces a p53‐ and ARF‐dependent growth arrest and cooperates with Ras in transformation The Embo Journal. 20: 4912-4922. PMID 11532955 DOI: 10.1093/Emboj/20.17.4912  0.449
2001 Maya R, Balass M, Kim ST, Shkedy D, Leal JF, Shifman O, Moas M, Buschmann T, Ronai Z, Shiloh Y, Kastan MB, Katzir E, Oren M. ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes & Development. 15: 1067-77. PMID 11331603 DOI: 10.1101/Gad.886901  0.49
2001 Strano S, Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, Sudol M, Cesareni G, Blandino G. Physical interaction with Yes-associated protein enhances p73 transcriptional activity. The Journal of Biological Chemistry. 276: 15164-73. PMID 11278685 DOI: 10.1074/Jbc.M010484200  0.494
2001 Oren M. Tumor suppressor perspective Experimental Cell Research. 264: 1. PMID 11237518 DOI: 10.1006/Excr.2000.5147  0.332
2001 Strano S, Fontemaggi G, Costanzo A, Rizzo MG, Levrero M, Sacchi A, Oren M, Blandino G. The p53 family: What implications in human carcinogenesis? European Journal of Cancer. 37. DOI: 10.1016/S0959-8049(01)81002-9  0.385
2001 Oren M, Kahan S, Shutah M, Zhurinsky J, Geiger B, Ben-Zeév A, Damalas A. Regulation of p53 activity: the cancer connection European Journal of Cancer. 37: S138. DOI: 10.1016/S0959-8049(01)81001-7  0.469
2000 Reinstein E, Scheffner M, Oren M, Ciechanover A, Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the N-terminal residue Oncogene. 19: 5944-5950. PMID 11127826 DOI: 10.1038/Sj.Onc.1203989  0.323
2000 Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 103: 321-30. PMID 11057904 DOI: 10.1016/S0092-8674(00)00123-9  0.513
2000 Blander G, Zalle N, Leal JF, Bar-Or RL, Yu CE, Oren M. The Werner syndrome protein contributes to induction of p53 by DNA damage. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2138-40. PMID 11023999 DOI: 10.1096/Fj.00-0171Fje  0.53
2000 Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proceedings of the National Academy of Sciences of the United States of America. 97: 11250-5. PMID 11016968 DOI: 10.1073/Pnas.210171597  0.529
2000 Maya R, Oren M. Unmasking of phosphorylation-sensitive epitopes on p53 and Mdm2 by a simple Western-phosphatase procedure Oncogene. 19: 3213-3215. PMID 10918576 DOI: 10.1038/Sj.Onc.1203658  0.327
2000 Strano S, Munarriz E, Rossi M, Cristofanelli B, Shaul Y, Castagnoli L, Levine AJ, Sacchi A, Cesareni G, Oren M, Blandino G. Physical and functional interaction between p53 mutants and different isoforms of p73. The Journal of Biological Chemistry. 275: 29503-12. PMID 10884390 DOI: 10.1074/Jbc.M003360200  0.588
2000 Amson R, Lassalle JM, Halley H, Prieur S, Lethrosne F, Roperch JP, Israeli D, Gendron MC, Duyckaerts C, Checler F, Dausset J, Cohen D, Oren M, Telerman A. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 5346-50. PMID 10805794 DOI: 10.1073/Pnas.97.10.5346  0.501
2000 de Rozieres S, Maya R, Oren M, Lozano G. The loss of mdm2 induces p53-mediated apoptosis. Oncogene. 19: 1691-7. PMID 10763826 DOI: 10.1038/Sj.Onc.1203468  0.572
1999 Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage Proceedings of the National Academy of Sciences of the United States of America. 96: 14973-14977. PMID 10611322 DOI: 10.1073/Pnas.96.26.14973  0.515
1999 Oren M. Regulation of the p53 tumor suppressor protein Journal of Biological Chemistry. 274: 36031-36034. PMID 10593882 DOI: 10.1074/Jbc.274.51.36031  0.51
1999 Blander G, Kipnis J, Leal JF, Yu CE, Schellenberg GD, Oren M. Physical and functional interaction between p53 and the Werner's syndrome protein. The Journal of Biological Chemistry. 274: 29463-9. PMID 10506209 DOI: 10.1074/Jbc.274.41.29463  0.554
1999 Roperch JP, Lethrone F, Prieur S, Piouffre L, Israeli D, Tuynder M, Nemani M, Pasturaud P, Gendron MC, Dausset J, Oren M, Amson RB, Telerman A. SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1). Proceedings of the National Academy of Sciences of the United States of America. 96: 8070-3. PMID 10393949 DOI: 10.1073/Pnas.96.14.8070  0.54
1999 Agami R, Blandino G, Oren M, Shaul Y. Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis. Nature. 399: 809-13. PMID 10391250 DOI: 10.1038/21697  0.44
1999 Unger T, Sionov RV, Moallem E, Yee CL, Howley PM, Oren M, Haupt Y. Mutations in serines 15 and 20 of human p53 impair its apoptotic activity. Oncogene. 18: 3205-12. PMID 10359526 DOI: 10.1038/Sj.Onc.1202656  0.546
1999 Damalas A, Ben-Ze'ev A, Simcha I, Shtutman M, Leal JF, Zhurinsky J, Geiger B, Oren M. Excess beta-catenin promotes accumulation of transcriptionally active p53. The Embo Journal. 18: 3054-63. PMID 10357817 DOI: 10.1093/Emboj/18.11.3054  0.445
1999 Zeng X, Chen L, Jost CA, Maya R, Keller D, Wang X, Kaelin WG, Oren M, Chen J, Lu H. MDM2 suppresses p73 function without promoting p73 degradation Molecular and Cellular Biology. 19: 3257-3266. PMID 10207051 DOI: 10.1128/Mcb.19.5.3257  0.572
1999 Juven-Gershon T, Oren M. MDM2: The ups and downs Molecular Medicine. 5: 71-83. PMID 10203572 DOI: 10.1007/Bf03402141  0.413
1999 Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, Oren M, Haupt Y. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. The Embo Journal. 18: 1805-14. PMID 10202144 DOI: 10.1093/Emboj/18.7.1805  0.55
1999 Sionov RV, Moallem E, Berger M, Kazaz A, Gerlitz O, Ben-Neriah Y, Oren M, Haupt Y. c-Abl neutralizes the inhibitory effect of Mdm2 on p53. The Journal of Biological Chemistry. 274: 8371-4. PMID 10085066 DOI: 10.1074/Jbc.274.13.8371  0.542
1999 Elkeles A, Juven-Gershon T, Israeli D, Wilder S, Zalcenstein A, Oren M. The c-fos proto-oncogene is a target for transactivation by the p53 tumor suppressor. Molecular and Cellular Biology. 19: 2594-600. PMID 10082525 DOI: 10.1128/Mcb.19.4.2594  0.535
1999 Oren M, Rotter V. Introduction. p53: The first twenty years Cellular and Molecular Life Sciences. 55: 9-11. PMID 10065147 DOI: 10.1007/S000180050265  0.551
1999 Blandino G, Levine AJ, Oren M. Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy. Oncogene. 18: 477-85. PMID 9927204 DOI: 10.1038/Sj.Onc.1202314  0.521
1998 Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, Li-Weber M, Friedman SL, Galle PR, Stremmel W, Oren M, Krammer PH. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. The Journal of Experimental Medicine. 188: 2033-45. PMID 9841917 DOI: 10.1084/Jem.188.11.2033  0.489
1998 Hosokawa K, Aharoni D, Dantes A, Shaulian E, Schere-Levy C, Atzmon R, Kotsuji F, Oren M, Vlodavsky I, Amsterdam A. Modulation of Mdm2 expression and p53-induced apoptosis in immortalized human ovarian granulosa cells. Endocrinology. 139: 4688-4700. PMID 9794481 DOI: 10.1210/Endo.139.11.6280  0.522
1998 Wang Y, Blandino G, Oren M, Givol D. Induced p53 expression in lung cancer cell line promotes cell senescence and differentially modifies the cytotoxicity of anti-cancer drugs Oncogene. 17: 1923-1930. PMID 9788435 DOI: 10.1038/Sj.Onc.1202113  0.493
1998 Yardley G, Zauberman A, Oren M, Jackson P. Individual promoter and intron p53-binding motifs from the rat Cyclin G1 promoter region support transcriptional activation by p53 but do not show co-operative activation. Febs Letters. 430: 171-5. PMID 9688532 DOI: 10.1016/S0014-5793(98)00650-4  0.492
1998 Gottlieb E, Oren M. p53 facilitates pRb cleavage in IL-3-deprived cells: Novel pro-apoptotic activity of p53 Embo Journal. 17: 3587-3596. PMID 9649429 DOI: 10.1093/Emboj/17.13.3587  0.46
1998 Juven-Gershon T, Shifman O, Unger T, Elkeles A, Haupt Y, Oren M. The Mdm2 Oncoprotein Interacts with the Cell Fate Regulator Numb Molecular and Cellular Biology. 18: 3974-3982. PMID 9632782 DOI: 10.1128/Mcb.18.7.3974  0.546
1998 Oren M. Teaming up to restrain cancer Nature. 391: 233-234. PMID 9440684 DOI: 10.1038/34551  0.464
1998 Ori A, Zauberman A, Doitsh G, Paran N, Oren M, Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. The Embo Journal. 17: 544-53. PMID 9430645 DOI: 10.1093/Emboj/17.2.544  0.507
1997 Gottlieb TM, Oren M. p53 and apoptosis Seminars in Cancer Biology. 8: 359-368. PMID 10101801 DOI: 10.1006/Scbi.1998.0098  0.523
1997 Zauberman A, Oren M, Zipori D. Involvement of p21(WAF1/Cip1), CDK4 and Rb in activin A mediated signaling leading to hepatoma cell growth inhibition Oncogene. 15: 1705-1711. PMID 9349504 DOI: 10.1038/Sj.Onc.1201348  0.515
1997 Oren M. Lonely no more: P53 finds its kin in a tumor suppressor haven Cell. 90: 829-832. PMID 9298894 DOI: 10.1016/S0092-8674(00)80347-5  0.523
1997 Israeli D, Tessler E, Haupt Y, Elkeles A, Wilder S, Amson R, Telerman A, Oren M. A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis. The Embo Journal. 16: 4384-92. PMID 9250682 DOI: 10.1093/Emboj/16.14.4384  0.56
1997 Friedman SL, Shaulian E, Littlewood T, Resnitzky D, Oren M. Resistance to p53-mediated growth arrest and apoptosis in Hep 3B hepatoma cells. Oncogene. 15: 63-70. PMID 9233778 DOI: 10.1038/Sj.Onc.1201149  0.558
1997 Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature. 387: 296-9. PMID 9153395 DOI: 10.1038/387296A0  0.583
1997 Gottlieb E, Haffner R, King A, Asher G, Gruss P, Lonai P, Oren M. Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis. The Embo Journal. 16: 1381-90. PMID 9135153 DOI: 10.1093/Emboj/16.6.1381  0.543
1997 Ruaro EM, Collavin L, Del Sal G, Haffner R, Oren M, Levine AJ, Schneider C. A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. Proceedings of the National Academy of Sciences of the United States of America. 94: 4675-80. PMID 9114050 DOI: 10.1073/Pnas.94.9.4675  0.523
1997 Hansen R, Oren M. p53; from inductive signal to cellular effect Current Opinion in Genetics and Development. 7: 46-51. PMID 9024633 DOI: 10.1016/S0959-437X(97)80108-6  0.513
1997 Tanaka N, Ishihara M, Lamphier MS, Nozawa H, Matsuyama T, Mak TW, Aizawa S, Tokino T, Oren M, Taniguchi T. Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage. Nature. 382: 816-8. PMID 8752276 DOI: 10.1038/382816A0  0.522
1996 Oren M, Prives C. p53: Upstream, downstream and off stream. Review of the 8th p53 workshop (Dundee, July 5-9, 1996) Biochimica Et Biophysica Acta - Reviews On Cancer. 1288. PMID 9011182 DOI: 10.1016/S0304-419X(96)00030-3  0.474
1996 Haupt Y, Oren M. p53-mediated apoptosis: mechanisms and regulation Behring Institute Mitteilungen. 32-59. PMID 8950466  0.475
1996 Bowman T, Symonds H, Gu L, Yin C, Oren M, Van Dyke T. Tissue-specific inactivation of p53 tumor suppression in the mouse. Genes & Development. 10: 826-35. PMID 8846919 DOI: 10.1101/Gad.10.7.826  0.557
1996 Gottlieb E, Lindner S, Oren M. Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells Cell Growth and Differentiation. 7: 301-310. PMID 8838860  0.4
1996 Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H, Roperch JP, Tuynder M, Bougueleret L, Cherif D, Medhioub M, Pasturaud P, Alvaro V, der Sarkissan H, Cazes L, Le Paslier D, Le Gall I, Israeli D, ... ... Oren M, et al. Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. Proceedings of the National Academy of Sciences of the United States of America. 93: 9039-42. PMID 8799150 DOI: 10.1073/Pnas.93.17.9039  0.422
1996 Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M. p53 plays a regulatory role in differentiation and apoptosis of central nervous system-associated cells Molecular and Cellular Biology. 16: 5178-5185. PMID 8756675 DOI: 10.1128/Mcb.16.9.5178  0.489
1996 Friedlander P, Haupt Y, Prives C, Oren M. A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis Molecular and Cellular Biology. 16: 4961-4971. PMID 8756655 DOI: 10.1128/Mcb.16.9.4961  0.566
1996 Gottlieb TM, Oren M. p53 in growth control and neoplasia Biochimica Et Biophysica Acta - Reviews On Cancer. 1287: 77-102. PMID 8672531 DOI: 10.1016/0304-419X(95)00019-C  0.402
1996 Knippschild U, Oren M, Deppert W. Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion Oncogene. 12: 1755-1765. PMID 8622896  0.409
1996 Haupt Y, Barak Y, Oren M. Cell type-specific inhibition of p53-mediated apoptosis by mdm2 Embo Journal. 15: 1596-1606. PMID 8612583 DOI: 10.1002/J.1460-2075.1996.Tb00504.X  0.528
1996 Rowan S, Ludwig RL, Haupt Y, Bates S, Lu X, Oren M, Vousden KH. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. The Embo Journal. 15: 827-838. DOI: 10.1002/J.1460-2075.1996.Tb00418.X  0.566
1995 Hiebert SW, Packham G, Strom DK, Haffner R, Oren M, Zambetti G, Cleveland JL. E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis Molecular and Cellular Biology. 15: 6864-6874. PMID 8524253 DOI: 10.1128/Mcb.15.12.6864  0.495
1995 Stuart ET, Haffner R, Oren M, Gruss P. Loss of p53 function through PAX-mediated transcriptional repression. The Embo Journal. 14: 5638-45. PMID 8521821 DOI: 10.1002/J.1460-2075.1995.Tb00251.X  0.555
1995 Shaulian E, Haviv I, Shaul Y, Oren M. Transcriptional repression by the C-terminal domain of p53 Oncogene. 10: 671-680. PMID 7862444  0.377
1995 Zauberman A, Lupo A, Oren M. Identification of p53 target genes through immune selection of genomic DNA: The cyclin G gene contains two distinct p53 binding sites Oncogene. 10: 2361-2366. PMID 7784084  0.39
1995 Haffner R, Oren M. Biochemical properties and biological effects of p53 Current Opinion in Genetics and Development. 5: 84-90. PMID 7749331 DOI: 10.1016/S0959-437X(95)90058-6  0.504
1995 Keren-Tal I, Suh B, Dantes A, Lindner S, Oren M, Amsterdam A. Involvement of p53 Expression in cAMP-Mediated Apoptosis in Immortalized Granulosa Cells Experimental Cell Research. 218: 283-295. PMID 7737366 DOI: 10.1006/Excr.1995.1157  0.454
1995 Haupt Y, Rowan S, Oren M. p53-mediated apoptosis in HeLa cells can be overcame by excess pRB Oncogene. 10: 1563-1571. PMID 7731711  0.457
1995 Eizenberg O, Faber-Elman A, Gottlieb E, Oren M, Rotter V, Schwartz M. Direct involvement of p53 in programmed cell death of oligodendrocytes Embo Journal. 14: 1136-1144. PMID 7720704 DOI: 10.1002/J.1460-2075.1995.Tb07097.X  0.45
1995 Haupt Y, Rowan S, Shaulian E, Vousden KH, Oren M. Induction of apoptosis in HeLa cells by trans-activation-deficient p53 Genes and Development. 9: 2170-2183. PMID 7657168 DOI: 10.1101/Gad.9.17.2170  0.577
1995 Zauberman A, Flusberg D, Haupt Y, Barak Y, Oren M. A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Research. 23: 2584-92. PMID 7651818 DOI: 10.1093/Nar/23.14.2584  0.519
1995 Barak Y, Lupo A, Zauberman A, Juven T, Aloni-Grinstein R, Gottlieb E, Rotter V, Oren M. Targets for transcriptional activation by wild-type p53: endogenous retroviral LTR, immunoglobulin-like promoter, and an internal promoter of the mdm2 gene. Cold Spring Harbor Symposia On Quantitative Biology. 59: 225-35. PMID 7587074 DOI: 10.1101/Sqb.1994.059.01.027  0.442
1995 Malcomson RDG, Oren M, Wyllie AH, Harrison DJ. P53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs British Journal of Cancer. 72: 952-957. PMID 7547247 DOI: 10.1038/Bjc.1995.440  0.494
1995 Aharoni D, Dantes A, Oren M, Amsterdam A. cAMP-mediated signals as determinants for apoptosis in primary granulosa cells Experimental Cell Research. 218: 271-282. PMID 7537693 DOI: 10.1006/Excr.1995.1156  0.359
1995 Haupt Y, Gottlieb E, Rowan S, Shaulian E, Oren M. 767 The role of p53 in the control of cell death European Journal of Cancer. 31: S160. DOI: 10.1016/0959-8049(95)96016-7  0.553
1994 Barak Y, Gottlieb E, Juven-Gershon T, Oren M. Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential. Genes & Development. 8: 1739-49. PMID 7958853 DOI: 10.1101/Gad.8.15.1739  0.577
1994 Oren M. Relationship of p53 to the control of apoptotic cell death Seminars in Cancer Biology. 5: 221-227. PMID 7948950  0.414
1994 Gottlieb E, Haffner R, Rüden Tv, Wagner EF, Oren M. Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. The Embo Journal. 13: 1368-1374. DOI: 10.1002/J.1460-2075.1994.Tb06390.X  0.466
1993 Yonish-Rouach E, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ, May P, Oren M. p53-mediated cell death: relationship to cell cycle control. Molecular and Cellular Biology. 13: 1415-23. PMID 8441387 DOI: 10.1128/Mcb.13.3.1415  0.498
1993 Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild type p53 activity Embo Journal. 12: 461-468. PMID 8440237 DOI: 10.1002/J.1460-2075.1993.Tb05678.X  0.562
1993 Telerman A, Tuynder M, Dupressoir T, Robaye B, Sigaux F, Shaulian E, Oren M, Rommelaere J, Amson R. A model for tumor suppression using H-1 parvovirus. Proceedings of the National Academy of Sciences of the United States of America. 90: 8702-8706. PMID 8378352 DOI: 10.1073/Pnas.90.18.8702  0.436
1993 Levy N, Yonish-Rouach E, Oren M, Kimchi A. Complementation by wild-type p53 of interleukin-6 effects on M1 cells: Induction of cell cycle exit and cooperativity with c-myc suppression Molecular and Cellular Biology. 13: 7942-7952. PMID 8247009 DOI: 10.1128/Mcb.13.12.7942  0.446
1993 Oren M. Involvement of p53 in cell fate and cancer European Journal of Cancer. 29: S11. DOI: 10.1016/0959-8049(93)90656-Z  0.386
1993 Zauberman A, Barak Y, Ragimov N, Levy N, Oren M. Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes. The Embo Journal. 12: 2799-2808. DOI: 10.1002/J.1460-2075.1993.Tb05941.X  0.513
1993 Shaulian E, Zauberman A, Milner J, Davies EA, Oren M. Tight DNA binding and oligomerization are dispensable for the ability of p53 to transactivate target genes and suppress transformation. The Embo Journal. 12: 2789-2797. DOI: 10.1002/J.1460-2075.1993.Tb05940.X  0.506
1992 Barak Y, Oren M. Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest Embo Journal. 11: 2115-2121. PMID 1600943 DOI: 10.1002/J.1460-2075.1992.Tb05270.X  0.555
1992 Shaulian E, Zauberman A, Ginsberg D, Oren M. Identification of a minimal transforming domain of p53: Negative dominance through abrogation of sequence-specific DNA binding Molecular and Cellular Biology. 12: 5581-5592. PMID 1448088 DOI: 10.1128/Mcb.12.12.5581  0.495
1992 Oren M. p53: The ultimate tumor suppressor gene? Faseb Journal. 6: 3169-3176. PMID 1397838 DOI: 10.1096/Fasebj.6.13.1397838  0.591
1992 Oren M. The involvement of oncogenes and tumor suppressor genes in the control of apoptosis Cancer and Metastasis Review. 11: 141-148. PMID 1394793 DOI: 10.1007/Bf00048060  0.357
1991 Michalovitz D, Halevy O, Oren M. p53 mutations: Gains or losses? Journal of Cellular Biochemistry. 45: 22-29. PMID 2005181 DOI: 10.1002/Jcb.240450108  0.522
1991 Ginsberg D, Michael-Michalovitz D, Oren M. Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein. Molecular and Cellular Biology. 11: 582-585. PMID 1986251 DOI: 10.1128/Mcb.11.1.582  0.398
1991 Ginsberg D, Mechta F, Yaniv M, Oren M. Wild-type p53 can down-modulate the activity of various promoters Proceedings of the National Academy of Sciences of the United States of America. 88: 9979-9983. PMID 1946467 DOI: 10.1073/Pnas.88.22.9979  0.55
1991 Halevy O, Rodel J, Peled A, Oren M. Frequent p53 mutations in chemically induced murine fibrosarcoma Oncogene. 6: 1593-1600. PMID 1923526  0.39
1991 Yonish-Rouach E, Resnftzky D, Lotem J, Sachs L, Kimchi A, Oren M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 Nature. 352: 345-347. PMID 1852210 DOI: 10.1038/352345A0  0.517
1991 Eizenberg O, Oren M. Reduced levels of α1 (I) collagen mRNA in cells immortalized by mutant p53 or transformed by ras Bba - Gene Structure and Expression. 1129: 34-42. PMID 1756178 DOI: 10.1016/0167-4781(91)90209-5  0.396
1991 Michael-Michalovitz D, Yehiely F, Gottlieb E, Oren M. Simian virus 40 can overcome the antiproliferative effect of wild-type p53 in the absence of stable large T antigen-p53 binding Journal of Virology. 65: 4160-4168. PMID 1649323 DOI: 10.1128/Jvi.65.8.4160-4168.1991  0.495
1990 Halevy O, Michalovitz D, Oren M. Different tumor-derived p53 mutants exhibited distinct biological activities Science. 250: 113-116. PMID 2218501 DOI: 10.1126/Science.2218501  0.549
1990 Ginsberg D, Oren M, Yaniv M, Piette J. Protein-binding elements in the promoter region of the mouse p53 gene Oncogene. 5: 1285-1290. PMID 2216454  0.33
1990 Michalovitz D, Halevy O, Oren M. Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53 Cell. 62: 671-680. PMID 2143698 DOI: 10.1016/0092-8674(90)90113-S  0.449
1989 Michalovitz D, Amsterdam A, Oren M. Interactions between SV40 and cellular oncogenes in the transformation of primary rat cells Current Topics in Microbiology and Immunology. 144: 63-75. PMID 2551593 DOI: 10.1007/978-3-642-74578-2_8  0.324
1989 Eliyahu D, Michalovitz D, Eliyahu S, Pinhasi-Kimhi O, Oren M. Wild-type p53 can inhibit oncogene-mediated focus formation Proceedings of the National Academy of Sciences of the United States of America. 86: 8763-8767. PMID 2530586 DOI: 10.1073/Pnas.86.22.8763  0.539
1989 Halevy O, Hall A, Oren M. Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: Effects of protein sequence and intracellular environment Molecular and Cellular Biology. 9: 3385-3392. PMID 2529426 DOI: 10.1128/Mcb.9.8.3385  0.527
1988 Kraiss S, Quaiser A, Oren M, Montenarh M. Oligomerization of oncoprotein p53 Journal of Virology. 62: 4737-4744. PMID 3054153 DOI: 10.1128/Jvi.62.12.4737-4744.1988  0.476
1988 Amsterdam A, Zauberman A, Meir G, Pinhasi-Kimhi O, Suh BS, Oren M. Cotransfection of granulosa cells with simian virus 40 and Ha-RAS oncogene generates stable lines capable of induced steroidogenesis. Proceedings of the National Academy of Sciences of the United States of America. 85: 7582-7586. PMID 2845413 DOI: 10.1073/Pnas.85.20.7582  0.356
1988 Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M, Levine AJ. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life Molecular and Cellular Biology. 8: 531-539. PMID 2832726 DOI: 10.1128/mcb.8.2.531-539.1988  0.465
1987 Oren M, Michalovitz D, Pinhasi-Kimhi O, Eliyahu D. Biological and molecular properties of p53 European Journal of Cancer and Clinical Oncology. 23: 1785. DOI: 10.1016/0277-5379(87)90669-9  0.417
1986 Pinhasi-Kimhi O, Michalovitz D, Ben-Zeev A, Oren M. Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature. 320: 182-4. PMID 3513022 DOI: 10.1038/320182A0  0.463
1986 Kaczmarek L, Oren M, Baserga R. Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis Experimental Cell Research. 162: 268-272. PMID 3509995 DOI: 10.1016/0014-4827(86)90445-3  0.46
1986 Isobe M, Emanuel BS, Givol D, Oren M, Croce CM. Localization of gene for human p53 tumour antigen to band 17p13 Nature. 320: 84-85. PMID 3456488 DOI: 10.1038/320084A0  0.359
1986 Michalovitz D, Eliyahu D, Oren M. Overproduction of protein p53 contributes to simian virus 40-mediated transformation Molecular and Cellular Biology. 6: 3531-3536. PMID 3025598 DOI: 10.1128/Mcb.6.10.3531  0.4
1985 Rogel A, Popliker M, Webb CG, Oren M. p53 cellular tumor antigen: Analysis of mRNA levels in normal adult tissues, embryos, and tumors Molecular and Cellular Biology. 5: 2851-2855. PMID 3915536  0.347
1985 Oren M. The p53 cellular tumor antigen: gene structure, expression and protein properties Bba - Reviews On Cancer. 823: 67-78. PMID 3902087 DOI: 10.1016/0304-419X(85)90015-0  0.445
1985 Eliyahu D, Michalovitz D, Oren M. Overproduction of p53 antigen makes established cells highly tumorigenic Nature. 316: 158-160. PMID 3892307 DOI: 10.1038/316158A0  0.501
1985 Bienz-Tadmor B, Zakut-Houri R, Libresco S, Givol D, Oren M. The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. The Embo Journal. 4: 3209-3213. DOI: 10.1002/J.1460-2075.1985.Tb04067.X  0.451
1985 Zakut-Houri R, Bienz-Tadmor B, Givol D, Oren M. Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. The Embo Journal. 4: 1251-1255. DOI: 10.1002/j.1460-2075.1985.tb03768.x  0.314
1984 Czosnek HH, Bienz B, Givol D, Zakut-Houri R, Pravtcheva DD, Ruddle FH, Oren M. The gene and the pseudogene for mouse p53 cellular tumor antigen are located on different chromosomes. Molecular and Cellular Biology. 4: 1638-40. PMID 6387444 DOI: 10.1128/Mcb.4.8.1638  0.368
1984 Wolf D, Admon S, Oren M, Rotter V. Abelson murine leukemia virus-transformed cells that lack p53 protein synthesis express aberrant p53 mRNA species Molecular and Cellular Biology. 4: 552-558. PMID 6144042 DOI: 10.1128/Mcb.4.3.552  0.405
1984 Eliyahu D, Raz A, Gruss P, Givol D, Oren M. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature. 312: 646-9. PMID 6095116 DOI: 10.1038/312646A0  0.5
1984 Pinhasi O, Oren M. Expression of the mouse p35 cellular tumor antigen in monkey cells Molecular and Cellular Biology. 4: 2180-2186. PMID 6095045 DOI: 10.1128/Mcb.4.10.2180  0.521
1984 Bienz B, Zakut-Houri R, Givol D, Oren M. Analysis of the gene coding for the murine cellular tumour antigen p53. The Embo Journal. 3: 2179-2183. DOI: 10.1002/J.1460-2075.1984.Tb02110.X  0.441
1983 Zakut-Houri R, Oren M, Bienz B, Lavie V, Hazum S, Givol D. A single gene and a pseudogene for the cellular tumour antigen p53 Nature. 306: 594-597. PMID 6646235 DOI: 10.1038/306594A0  0.488
1983 Reich NC, Oren M, Levine AJ. Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53 Molecular and Cellular Biology. 3: 2143-2150. PMID 6318085 DOI: 10.1128/mcb.3.12.2143-2150.1983  0.413
1983 Oren M, Levine AJ. Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen Proceedings of the National Academy of Sciences of the United States of America. 80: 56-59. PMID 6296874 DOI: 10.1073/Pnas.80.1.56  0.394
1983 Oren M, Bienz B, Givol D, Rechavi G, Zakut R. Analysis of recombinant DNA clones specific for the murine p53 cellular tumor antigen. The Embo Journal. 2: 1633-1639. DOI: 10.1002/J.1460-2075.1983.Tb01637.X  0.482
1982 Oren M, Reich NC, Levine AJ. Regulation of the cellular p53 tumor antigen in teratocarcinoma cells and their differentiated progeny Molecular and Cellular Biology. 2: 443-449. PMID 6287239 DOI: 10.1128/mcb.2.4.443-449.1982  0.404
1982 Levine AJ, Kaplan L, Oren M. The regulation of a cellular protein, p53, in transformed cells and its association with viral tumor antigens Hepatology. 2.  0.384
1977 Gluzman Y, Davison J, Oren M, Winocour E. Properties of permissive monkey cells transformed by UV-irradiated simian virus 40. Journal of Virology. 22: 256-66. PMID 194053 DOI: 10.1128/Jvi.22.2.256-266.1977  0.301
Show low-probability matches.