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Kushol Gupta, Ph.D. - Publications

Affiliations: 
2003 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry, Pharmacology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cory MB, Li A, Hurley CM, Carman PJ, Pumroy RA, Hostetler ZM, Perez RM, Venkatesh Y, Li X, Gupta K, Petersson EJ, Kohli RM. The LexA-RecA* structure reveals a cryptic lock-and-key mechanism for SOS activation. Nature Structural & Molecular Biology. PMID 38755298 DOI: 10.1038/s41594-024-01317-3  0.301
2022 Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J. Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Reports. 40: 111408. PMID 36170828 DOI: 10.1016/j.celrep.2022.111408  0.312
2021 Maciunas LJ, Porter N, Lee PJ, Gupta K, Loll PJ. Structures of full-length VanR from Streptomyces coelicolor in both the inactive and activated states. Acta Crystallographica. Section D, Structural Biology. 77: 1027-1039. PMID 34342276 DOI: 10.1107/S2059798321006288  0.616
2020 Eilers G, Gupta K, Allen A, Zhou J, Hwang Y, Cory MB, Bushman FD, Van Duyne G. Influence of the amino-terminal sequence on the structure and function of HIV integrase. Retrovirology. 17: 28. PMID 32867805 DOI: 10.1186/S12977-020-00537-X  0.319
2020 O'Brien ES, Fuglestad B, Lessen HJ, Stetz MA, Lin DW, Marques BS, Gupta K, Fleming KG, Wand JJ. Membrane Proteins Have Distinct Fast Internal Motion and Residual Conformational Entropy. Angewandte Chemie (International Ed. in English). PMID 32277554 DOI: 10.1002/Anie.202003527  0.327
2020 Ronnebaum TA, Gupta K, Christianson DW. Higher-Order Oligomerization of a Chimeric αβγ Bifunctional Diterpene Synthase with Prenyltransferase and Class II Cyclase Activities is Concentration-Dependent. Journal of Structural Biology. 107463. PMID 31978464 DOI: 10.1016/J.Jsb.2020.107463  0.701
2019 Arturo EC, Gupta K, Hansen MR, Borne E, Jaffe EK. Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium. The Journal of Biological Chemistry. PMID 31076506 DOI: 10.1074/Jbc.Ra119.008294  0.466
2018 Li H, Sharp R, Rutherford K, Gupta K, Van Duyne GD. Serine Integrase attP Binding and Specificity. Journal of Molecular Biology. PMID 30227134 DOI: 10.1016/J.Jmb.2018.09.007  0.399
2018 Ray-Gallet D, Ricketts MD, Sato Y, Gupta K, Boyarchuk E, Senda T, Marmorstein R, Almouzni G. Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit. Nature Communications. 9: 3103. PMID 30082790 DOI: 10.1038/S41467-018-05581-Y  0.334
2017 Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, et al. Self-oligomerization regulates stability of Survival Motor Neuron (SMN) protein isoforms by sequestering an SCF(Slmb) degron. Molecular Biology of the Cell. PMID 29167380 DOI: 10.1091/Mbc.E17-11-0627  0.308
2017 Gupta K, Sharp R, Yuan JB, Li H, Van Duyne GD. Coiled-coil interactions mediate serine integrase directionality. Nucleic Acids Research. PMID 28549184 DOI: 10.1093/Nar/Gkx474  0.421
2017 Mandali S, Gupta K, Dawson AR, Van Duyne GD, Johnson RC. Control of recombination directionality by the Listeria phage A118 protein Gp44 and the coiled-coil motif of its serine integrase. Journal of Bacteriology. PMID 28289084 DOI: 10.1128/Jb.00019-17  0.356
2016 Gupta K, Turkki V, Sherrill-Mix S, Hwang Y, Eilers G, Taylor L, McDanal C, Wang P, Temelkoff D, Nolte RT, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD. Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. Plos Biology. 14: e1002584. PMID 27935939 DOI: 10.1371/Journal.Pbio.1002584  0.405
2016 Eisemann T, McCauley M, Langelier MF, Gupta K, Roy S, Van Duyne GD, Pascal JM. Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification. Structure (London, England : 1993). PMID 27594684 DOI: 10.1016/J.Str.2016.07.014  0.466
2016 Arturo EC, Gupta K, Héroux A, Stith L, Cross PJ, Parker EJ, Loll PJ, Jaffe EK. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proceedings of the National Academy of Sciences of the United States of America. PMID 26884182 DOI: 10.1073/Pnas.1516967113  0.647
2015 Gupta K, Martin R, Sharp R, Sarachan KL, Ninan NS, Van Duyne GD. Oligomeric Properties of Survival Motor Neuron·Gemin2 Complexes. The Journal of Biological Chemistry. PMID 26092730 DOI: 10.1074/Jbc.M115.667279  0.356
2015 Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LE, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE. Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science (New York, N.Y.). 348: 699-703. PMID 25954010 DOI: 10.1126/Science.1259308  0.302
2015 Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Molecular Cell. 57: 836-49. PMID 25620563 DOI: 10.1016/J.Molcel.2014.12.021  0.319
2015 Gupta K, Selinsky BS. Bacterial and algal orthologs of prostaglandin Hâ‚‚synthase: novel insights into the evolution of an integral membrane protein. Biochimica Et Biophysica Acta. 1848: 83-94. PMID 25281773 DOI: 10.1016/J.Bbamem.2014.09.011  0.376
2014 Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G. p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 15946-51. PMID 25349408 DOI: 10.1073/Pnas.1408552111  0.308
2014 Gupta K, Brady T, Dyer BM, Malani N, Hwang Y, Male F, Nolte RT, Wang L, Velthuisen E, Jeffrey J, Van Duyne GD, Bushman FD. Allosteric inhibition of human immunodeficiency virus integrase: late block during viral replication and abnormal multimerization involving specific protein domains. The Journal of Biological Chemistry. 289: 20477-88. PMID 24904063 DOI: 10.1074/Jbc.M114.551119  0.349
2014 Gupta K, Contreras LM, Smith D, Qu G, Huang T, Spruce LA, Seeholzer SH, Belfort M, Van Duyne GD. Quaternary arrangement of an active, native group II intron ribonucleoprotein complex revealed by small-angle X-ray scattering. Nucleic Acids Research. 42: 5347-60. PMID 24567547 DOI: 10.1093/Nar/Gku140  0.369
2014 Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. The Journal of Biological Chemistry. 289: 848-67. PMID 24280225 DOI: 10.1074/Jbc.M113.520759  0.339
2013 Sekulic N, Falk SJ, Mani T, Gupta K, Van Duyne G, Vinogradov SA, Black BE. CENP-A Nucleosomes adopt an Unconventional Shape Biophysical Journal. 104: 578a-579a. DOI: 10.1016/J.Bpj.2012.11.3212  0.34
2013 Rutherford K, Gupta K, Van Duyne G. Solution Scattering Studies of Large Serine Recombinase-DNA Complexes Biophysical Journal. 104: 368a. DOI: 10.1016/J.Bpj.2012.11.2046  0.386
2013 Sweeny EA, Gupta K, Shorter J. Conformational Changes of Hsp104 Revealed through Small Angle X-Ray Scattering (SAXS) Biophysical Journal. 104: 182a. DOI: 10.1016/J.Bpj.2012.11.1026  0.346
2013 Gupta K, Sekulic N, Sarachan K, Curtis JE, Krueger S, Black BE, Van Duyne GD. The Nucleosome Revisited: Combined Small-Angle X-Ray/Neutron Scattering and Molecular Dynamics Applied to Reconstituted Mononucleosomes Biophysical Journal. 104: 182a. DOI: 10.1016/J.Bpj.2012.11.1025  0.358
2012 Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD. The survival motor neuron protein forms soluble glycine zipper oligomers. Structure (London, England : 1993). 20: 1929-39. PMID 23022347 DOI: 10.1016/J.Str.2012.08.024  0.325
2012 Gupta K, Curtis JE, Krueger S, Hwang Y, Cherepanov P, Bushman FD, Van Duyne GD. Solution conformations of prototype foamy virus integrase and its stable synaptic complex with U5 viral DNA. Structure (London, England : 1993). 20: 1918-28. PMID 23000384 DOI: 10.1016/J.Str.2012.08.023  0.365
2012 Larue R, Gupta K, Wuensch C, Shkriabai N, Kessl JJ, Danhart E, Feng L, Taltynov O, Christ F, Van Duyne GD, Debyser Z, Foster MP, Kvaratskhelia M. Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2). The Journal of Biological Chemistry. 287: 34044-58. PMID 22872640 DOI: 10.1074/Jbc.M112.384669  0.361
2012 Sarachan KL, Valentine KG, Gupta K, Moorman VR, Gledhill JM, Bernens M, Tommos C, Wand AJ, Van Duyne GD. Solution structure of the core SMN-Gemin2 complex. The Biochemical Journal. 445: 361-70. PMID 22607171 DOI: 10.1042/Bj20120241  0.416
2011 Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 18678-83. PMID 22049338 DOI: 10.1073/Pnas.1113813108  0.413
2011 Huang T, Shaikh TR, Gupta K, Contreras-Martin LM, Grassucci RA, Van Duyne GD, Frank J, Belfort M. The group II intron ribonucleoprotein precursor is a large, loosely packed structure Nucleic Acids Research. 39: 2845-2854. PMID 21131279 DOI: 10.1093/Nar/Gkq1202  0.357
2010 Gibb B, Gupta K, Ghosh K, Sharp R, Chen J, Van Duyne GD. Requirements for catalysis in the Cre recombinase active site. Nucleic Acids Research. 38: 5817-32. PMID 20462863 DOI: 10.1093/Nar/Gkq384  0.365
2010 Gupta K, Diamond T, Hwang Y, Bushman F, Van Duyne GD. Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers. The Journal of Biological Chemistry. 285: 20303-15. PMID 20406807 DOI: 10.1074/Jbc.M110.114413  0.432
2008 Yuan P, Gupta K, Van Duyne GD. Tetrameric structure of a serine integrase catalytic domain. Structure (London, England : 1993). 16: 1275-86. PMID 18682229 DOI: 10.1016/J.Str.2008.04.018  0.43
2006 Gupta K, Selinsky BS, Loll PJ. 2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor. Acta Crystallographica. Section D, Biological Crystallography. 62: 151-6. PMID 16421446 DOI: 10.1107/S0907444905036309  0.617
2004 Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ. Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 667-71. PMID 14741265 DOI: 10.1016/J.Bmcl.2003.11.034  0.588
2004 Gupta K, Selinsky BS, Kaub CJ, Katz AK, Loll PJ. The 2.0 A resolution crystal structure of prostaglandin H2 synthase-1: structural insights into an unusual peroxidase. Journal of Molecular Biology. 335: 503-18. PMID 14672659 DOI: 10.1016/J.Jmb.2003.10.073  0.646
2001 Mattoon D, Gupta K, Doyon J, Loll PJ, DiMaio D. Identification of the transmembrane dimer interface of the bovine papillomavirus E5 protein. Oncogene. 20: 3824-34. PMID 11439346 DOI: 10.1038/Sj.Onc.1204523  0.611
2001 Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 40: 5172-80. PMID 11318639 DOI: 10.1021/Bi010045S  0.63
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