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Dejian Ren - Publications

Affiliations: 
Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
calcium signaling, ion channel
Website:
http://www.bio.upenn.edu/faculty/ren/
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Alexander SPH, Mathie AA, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Davies JA, Aldrich RW, Attali B, Baggetta AM, Becirovic E, Biel M, ... ... Ren D, et al. The Concise Guide to PHARMACOLOGY 2023/24: Ion channels. British Journal of Pharmacology. S145-S222. PMID 38123150 DOI: 10.1111/bph.16178  0.489
2023 Bayat A, Liu Z, Luo S, Fenger CD, Hojte AF, Isidor B, Cogne B, Larson A, Zanus C, Flavio F, Keren B, Musante L, Gourfinkel-An I, Perrine C, Demily C, ... ... Ren D, et al. A new neurodevelopmental disorder linked to heterozygous variants in UNC79. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 100894. PMID 37183800 DOI: 10.1016/j.gim.2023.100894  0.342
2023 Miller AN, Houlihan PR, Matamala E, Cabezas-Bratesco D, Lee GY, Cristofori-Armstrong B, Dilan TL, Sanchez-Martinez S, Matthies D, Yan R, Yu Z, Ren D, Brauchi SE, Clapham DE. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins. Elife. 12. PMID 36695574 DOI: 10.7554/eLife.84477  0.696
2022 Miller AN, Houlihan PR, Matamala E, Cabezas-Bratesco D, Lee GY, Cristofori-Armstrong B, Dilan TL, Sanchez-Martinez S, Matthies D, Yan R, Yu Z, Ren D, Brauchi SE, Clapham DE. The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins. Biorxiv : the Preprint Server For Biology. PMID 36263072 DOI: 10.1101/2022.09.02.506428  0.695
2022 Riederer E, Cang C, Ren D. Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets? Annual Review of Pharmacology and Toxicology. PMID 36151054 DOI: 10.1146/annurev-pharmtox-051921-013755  0.479
2021 Wang Y, Zeng W, Lin B, Yao Y, Li C, Hu W, Wu H, Huang J, Zhang M, Xue T, Ren D, Qu L, Cang C. CLN7 is an organellar chloride channel regulating lysosomal function. Science Advances. 7: eabj9608. PMID 34910516 DOI: 10.1126/sciadv.abj9608  0.453
2021 Alexander SP, Mathie A, Peters JA, Veale EL, Striessnig J, Kelly E, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Aldrich RW, Attali B, Baggetta AM, ... ... Ren D, et al. THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels. British Journal of Pharmacology. 178: S157-S245. PMID 34529831 DOI: 10.1111/bph.15539  0.492
2021 Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. Author Correction: A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33790472 DOI: 10.1038/s41586-021-03438-x  0.671
2021 Wie J, Liu Z, Song H, Tropea TF, Yang L, Wang H, Liang Y, Cang C, Aranda K, Lohmann J, Yang J, Lu B, Chen-Plotkin AS, Luk KC, Ren D. A growth-factor-activated lysosomal K channel regulates Parkinson's pathology. Nature. PMID 33505021 DOI: 10.1038/s41586-021-03185-z  0.662
2020 Wie J, Bharthur A, Wolfgang M, Narayanan V, Ramsey K, Aranda K, Zhang Q, Zhou Y, Ren D. Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex. Nature Communications. 11: 3351. PMID 32620897 DOI: 10.1038/S41467-020-17105-8  0.507
2019 Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S. Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance. Science (New York, N.Y.). PMID 31806695 DOI: 10.1126/Science.Aaw9544  0.426
2018 Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, ... ... Ren D, et al. ORAI1, STIM1/2, and RYR1 shape subsecond Ca microdomains upon T cell activation. Science Signaling. 11. PMID 30563862 DOI: 10.1126/Scisignal.Aat0358  0.301
2018 Ford NC, Ren D, Baccei ML. Nalcn Channels Enhance the Intrinsic Excitability of Spinal Projection Neurons. Pain. PMID 29746349 DOI: 10.1097/J.Pain.0000000000001258  0.386
2017 Hirschi M, Herzik MA, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature. PMID 29019979 DOI: 10.1038/Nature24055  0.577
2017 Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C. Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes. Nature Protocols. 12: 1639-1658. PMID 28726848 DOI: 10.1038/Nprot.2017.036  0.549
2017 Lee C, Guo J, Zeng W, Kim S, She J, Cang C, Ren D, Jiang Y. The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature. PMID 28723891 DOI: 10.1038/Nature23269  0.568
2017 Yeh SY, Huang WH, Wang W, Ward CS, Chao ES, Wu Z, Tang B, Tang J, Sun JJ, Esther van der Heijden M, Gray PA, Xue M, Ray RS, Ren D, Zoghbi HY. Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn. Neuron. PMID 28392070 DOI: 10.1016/J.Neuron.2017.03.024  0.421
2015 Stray-Pedersen A, Cobben JM, Prescott TE, Lee S, Cang C, Aranda K, Ahmed S, Alders M, Gerstner T, Aslaksen K, Tétreault M, Qin W, Hartley T, Jhangiani SN, Muzny DM, ... ... Ren D, et al. Biallelic Mutations in UNC80 Cause Persistent Hypotonia, Encephalopathy, Growth Retardation, and Severe Intellectual Disability. American Journal of Human Genetics. PMID 26708751 DOI: 10.1016/J.Ajhg.2015.11.004  0.516
2015 Guo J, Zeng W, Chen Q, Lee C, Chen L, Yang Y, Cang C, Ren D, Jiang Y. Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature. PMID 26689363 DOI: 10.1038/Nature16446  0.506
2015 Cang C, Aranda K, Seo YJ, Gasnier B, Ren D. TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function. Cell. 162: 1101-12. PMID 26317472 DOI: 10.1016/J.Cell.2015.08.002  0.449
2015 Flourakis M, Kula-Eversole E, Hutchison AL, Han TH, Aranda K, Moose DL, White KP, Dinner AR, Lear BC, Ren D, Diekman CO, Raman IM, Allada R. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell. 162: 836-48. PMID 26276633 DOI: 10.1016/J.Cell.2015.07.036  0.433
2015 Xu H, Ren D. Lysosomal physiology. Annual Review of Physiology. 77: 57-80. PMID 25668017 DOI: 10.1146/annurev-physiol-021014-071649  0.325
2014 Cang C, Aranda K, Ren D. A non-inactivating high-voltage-activated two-pore Na⁺ channel that supports ultra-long action potentials and membrane bistability. Nature Communications. 5: 5015. PMID 25256615 DOI: 10.1038/Ncomms6015  0.559
2014 Cang C, Bekele B, Ren D. The voltage-gated sodium channel TPC1 confers endolysosomal excitability. Nature Chemical Biology. 10: 463-9. PMID 24776928 DOI: 10.1038/Nchembio.1522  0.58
2014 Cang C, ren d. A Lysosomal ATP-Sensitive Sodium Channel and its Regulation by Metabolism Biophysical Journal. 106: 761. DOI: 10.1016/J.Bpj.2013.11.4187  0.624
2013 Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D. mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell. 152: 778-90. PMID 23394946 DOI: 10.1016/J.Cell.2013.01.023  0.674
2012 Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151: 372-83. PMID 23063126 DOI: 10.1016/J.Cell.2012.08.036  0.701
2012 Kim BJ, Chang IY, Choi S, Jun JY, Jeon JH, Xu WX, Kwon YK, Ren D, So I. Involvement of Na(+)-leak channel in substance P-induced depolarization of pacemaking activity in interstitial cells of Cajal. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 29: 501-10. PMID 22508057 DOI: 10.1159/000338504  0.363
2012 Lishko PV, Kirichok Y, Ren D, Navarro B, Chung JJ, Clapham DE. The control of male fertility by spermatozoan ion channels. Annual Review of Physiology. 74: 453-75. PMID 22017176 DOI: 10.1146/Annurev-Physiol-020911-153258  0.763
2012 Wang X, Zhang X, Dong X, Samie M, Li X, Shen D, Cheng X, Goschka A, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H. Novel Na+-Selective Channels in the Lysosome Biophysical Journal. 102: 105a. DOI: 10.1016/J.Bpj.2011.11.590  0.619
2011 Ren D. Sodium leak channels in neuronal excitability and rhythmic behaviors. Neuron. 72: 899-911. PMID 22196327 DOI: 10.1016/J.Neuron.2011.12.007  0.436
2011 Ren D. Calcium signaling in sperm: help from prostasomes. Science Signaling. 4: pe27. PMID 21586726 DOI: 10.1126/Scisignal.2002102  0.322
2010 Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D. Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron. 68: 488-99. PMID 21040849 DOI: 10.1016/J.Neuron.2010.09.014  0.693
2010 Ren D, Xia J. Calcium signaling through CatSper channels in mammalian fertilization. Physiology (Bethesda, Md.). 25: 165-75. PMID 20551230 DOI: 10.1152/Physiol.00049.2009  0.56
2010 Ren D. Sperm and the proton channel. The New England Journal of Medicine. 362: 1934-5. PMID 20484401 DOI: 10.1056/Nejmcibr1001843  0.511
2010 Tang QY, Zhang Z, Xia J, Ren D, Logothetis DE. Phosphatidylinositol 4,5-bisphosphate activates Slo3 currents and its hydrolysis underlies the epidermal growth factor-induced current inhibition. The Journal of Biological Chemistry. 285: 19259-66. PMID 20392696 DOI: 10.1074/Jbc.M109.100156  0.642
2010 Ren D, Xu B, Zhang Q, Wang H, Nakayama M. Regulation of NALCN Sodium Leak Channel by UNC79 and UNC80 Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2906  0.632
2009 Xia J, Ren D. The BSA-induced Ca2+ influx during sperm capacitation is CATSPER channel-dependent. Reproductive Biology and Endocrinology : Rb&E. 7: 119. PMID 19860887 DOI: 10.1186/1477-7827-7-119  0.304
2009 Wang H, Ren D. UNC80 functions as a scaffold for Src kinases in NALCN channel function. Channels (Austin, Tex.). 3: 161-3. PMID 19535918 DOI: 10.4161/Chan.3.3.8853  0.596
2009 Wang H, Liu J, Cho KH, Ren D. A novel, single, transmembrane protein CATSPERG is associated with CATSPER1 channel protein. Biology of Reproduction. 81: 539-44. PMID 19516020 DOI: 10.1095/Biolreprod.109.077107  0.537
2009 Xia J, Ren D. Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels. Biology of Reproduction. 80: 1092-8. PMID 19211808 DOI: 10.1095/Biolreprod.108.074039  0.431
2009 Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80. Nature. 457: 741-4. PMID 19092807 DOI: 10.1038/Nature07579  0.736
2009 Lu B, Su Y, Das S, Wang H, Wang Y, Liu J, Ren D. Regulation of the NALCN Sodium Leak Channel by Neuropeptides Biophysical Journal. 96: 561a. DOI: 10.1016/J.Bpj.2008.12.3682  0.76
2007 Xia J, Reigada D, Mitchell CH, Ren D. CATSPER channel-mediated Ca2+ entry into mouse sperm triggers a tail-to-head propagation. Biology of Reproduction. 77: 551-9. PMID 17554080 DOI: 10.1095/Biolreprod.107.061358  0.46
2007 Liu J, Xia J, Cho KH, Clapham DE, Ren D. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. The Journal of Biological Chemistry. 282: 18945-52. PMID 17478420 DOI: 10.1074/Jbc.M701083200  0.694
2007 Lu B, Su Y, Das S, Liu J, Xia J, Ren D. The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 129: 371-83. PMID 17448995 DOI: 10.1016/J.Cell.2007.02.041  0.724
2004 Koishi R, Xu H, Ren D, Navarro B, Spiller BW, Shi Q, Clapham DE. A superfamily of voltage-gated sodium channels in bacteria. The Journal of Biological Chemistry. 279: 9532-8. PMID 14665618 DOI: 10.1074/Jbc.M313100200  0.625
2003 Carlson AE, Westenbroek RE, Quill T, Ren D, Clapham DE, Hille B, Garbers DL, Babcock DF. CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Proceedings of the National Academy of Sciences of the United States of America. 100: 14864-8. PMID 14657352 DOI: 10.1073/Pnas.2536658100  0.671
2002 Yue L, Navarro B, Ren D, Ramos A, Clapham DE. The cation selectivity filter of the bacterial sodium channel, NaChBac. The Journal of General Physiology. 120: 845-53. PMID 12451053 DOI: 10.1085/Jgp.20028699  0.699
2001 Ren D, Navarro B, Xu H, Yue L, Shi Q, Clapham DE. A prokaryotic voltage-gated sodium channel. Science (New York, N.Y.). 294: 2372-5. PMID 11743207 DOI: 10.1126/Science.1065635  0.73
2001 Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 98: 12527-31. PMID 11675491 DOI: 10.1073/Pnas.221454998  0.687
2001 Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 413: 603-9. PMID 11595941 DOI: 10.1038/35098027  0.606
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