Craig B. Wilen, Ph.D. - Publications

Affiliations: 
2011 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Virology Biology, Microbiology Biology, Molecular Biology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Xu D, Jiang W, Wu L, Gaudet RG, Park ES, Su M, Cheppali SK, Cheemarla NR, Kumar P, Uchil PD, Grover JR, Foxman EF, Brown CM, Stansfeld PJ, Bewersdorf J, ... ... Wilen CB, et al. PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection. Nature. PMID 37438530 DOI: 10.1038/s41586-023-06322-y  0.321
2023 Kennedy EA, Aggarwal S, Dhar A, Karst SM, Wilen CB, Baldridge MT. Age-associated features of norovirus infection analysed in mice. Nature Microbiology. PMID 37188813 DOI: 10.1038/s41564-023-01383-1  0.342
2023 Wei J, Patil A, Collings CK, Alfajaro MM, Liang Y, Cai WL, Strine MS, Filler RB, DeWeirdt PC, Hanna RE, Menasche BL, Ökten A, Peña-Hernández MA, Klein J, McNamara A, ... ... Wilen CB, et al. Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. Nature Genetics. PMID 36894709 DOI: 10.1038/s41588-023-01307-z  0.35
2022 Ortega-Gonzalez P, Taylor G, Jangra RK, Tenorio R, Fernandez de Castro I, Mainou BA, Orchard RC, Wilen CB, Brigleb PH, Sojati J, Chandran K, Sachse M, Risco C, Dermody TS. Reovirus infection is regulated by NPC1 and endosomal cholesterol homeostasis. Plos Pathogens. 18: e1010322. PMID 35263388 DOI: 10.1371/journal.ppat.1010322  0.332
2022 Sharon AJ, Filyk HA, Fonseca NM, Simister RL, Filler RB, Yuen W, Hardman BK, Robinson HG, Seo JH, Rocha-Pereira J, Welch I, Neyts J, Wilen CB, Crowe SA, Osborne LC. Restriction of viral replication, rather than T cell immunopathology, drives lethality in MNV CR6-infected STAT1-deficient mice. Journal of Virology. jvi0206521. PMID 35107369 DOI: 10.1128/jvi.02065-21  0.342
2021 Mao T, Israelow B, Lucas C, Vogels CBF, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Wilen CB, Landry ML, Grubaugh ND, Pyle AM, Iwasaki A. A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice. Biorxiv : the Preprint Server For Biology. PMID 34159330 DOI: 10.1101/2021.06.16.448754  0.306
2021 Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, ... ... Wilen CB, et al. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. Plos Biology. 19: e3001143. PMID 33730024 DOI: 10.1371/journal.pbio.3001143  0.311
2021 Walker FC, Hassan E, Peterson ST, Rodgers R, Schriefer LA, Thompson CE, Li Y, Kalugotla G, Blum-Johnston C, Lawrence D, McCune BT, Graziano VR, Lushniak L, Lee S, Roth AN, ... ... Wilen CB, et al. Norovirus evolution in immunodeficient mice reveals potentiated pathogenicity via a single nucleotide change in the viral capsid. Plos Pathogens. 17: e1009402. PMID 33705489 DOI: 10.1371/journal.ppat.1009402  0.312
2020 Chen JS, Alfajaro MM, Wei J, Chow RD, Filler RB, Eisenbarth SC, Wilen CB. Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication. Biorxiv : the Preprint Server For Biology. PMID 32995789 DOI: 10.1101/2020.09.24.312769  0.321
2020 Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal of Experimental Medicine. 217. PMID 32750141 DOI: 10.1084/Jem.20201241  0.382
2020 Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S. CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner. Journal of Virology. PMID 32581099 DOI: 10.1128/Jvi.00837-20  0.424
2020 Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, ... ... Wilen C, et al. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. Bmc Neurology. 20: 248. PMID 32552792 DOI: 10.1186/S12883-020-01812-2  0.336
2020 Ravindra NG, Alfajaro MM, Gasque V, Wei J, Filler RB, Huston NC, Wan H, Szigeti-Buck K, Wang B, Montgomery RR, Eisenbarth SC, Williams A, Pyle AM, Iwasaki A, Horvath TL, ... ... Wilen CB, et al. Single-cell longitudinal analysis of SARS-CoV-2 infection in human bronchial epithelial cells. Biorxiv : the Preprint Server For Biology. PMID 32511382 DOI: 10.1101/2020.05.06.081695  0.311
2020 Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, ... ... Wilen CB, et al. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. Plos Pathogens. 16: e1008242. PMID 32251490 DOI: 10.1371/Journal.Ppat.1008242  0.429
2020 Wang YT, Zaitsev K, Lu Q, Li S, Schaiff WT, Kim KW, Droit L, Wilen CB, Desai C, Balce DR, Orchard RC, Orvedahl A, Park S, Kreamalmeyer D, Handley SA, et al. Select autophagy genes maintain quiescence of tissue-resident macrophages and increase susceptibility to Listeria monocytogenes. Nature Microbiology. PMID 31959973 DOI: 10.1038/S41564-019-0633-0  0.329
2019 Grau KR, Zhu S, Peterson ST, Helm EW, Philip D, Phillips M, Hernandez A, Turula H, Frasse P, Graziano VR, Wilen CB, Wobus CE, Baldridge MT, Karst SM. The intestinal regionalization of acute norovirus infection is regulated by the microbiota via bile acid-mediated priming of type III interferon. Nature Microbiology. PMID 31768030 DOI: 10.1038/S41564-019-0602-7  0.398
2019 Hosmillo M, Lu J, McAllaster MR, Eaglesham JB, Wang X, Emmott E, Domingues P, Chaudhry Y, Fitzmaurice TJ, Tung MK, Panas MD, McInerney G, Locker N, Wilen CB, Goodfellow IG. Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation. Elife. 8. PMID 31403400 DOI: 10.7554/Elife.46681  0.389
2019 Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, Virgin HW, Smith TJ. Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion. Journal of Virology. PMID 31341042 DOI: 10.1128/Jvi.00970-19  0.329
2019 Fritzlar S, Aktepe TE, Chao YW, Kenney ND, McAllaster MR, Wilen CB, White PA, Mackenzie JM. Mouse Norovirus Infection Arrests Host Cell Translation Uncoupled from the Stress Granule-PKR-eIF2α Axis. Mbio. 10. PMID 31213553 DOI: 10.1128/Mbio.00960-19  0.423
2019 Graziano VR, Wei J, Wilen CB. Norovirus Attachment and Entry. Viruses. 11. PMID 31151248 DOI: 10.3390/V11060495  0.411
2019 Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host & Microbe. PMID 31130511 DOI: 10.1016/J.Chom.2019.04.005  0.448
2018 Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH. Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 30194229 DOI: 10.1073/Pnas.1805797115  0.33
2018 Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS. Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease. The Journal of Clinical Investigation. PMID 30137026 DOI: 10.1172/Jci120453  0.305
2018 Orchard RC, Wilen CB, Virgin HW. Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection. Nature Microbiology. PMID 30127493 DOI: 10.1038/S41564-018-0221-8  0.437
2018 Wilen CB, Lee S, Hsieh LL, Orchard RC, Desai C, Hykes BL, McAllaster MR, Balce DR, Feehley T, Brestoff JR, Hickey CA, Yokoyama CC, Wang YT, MacDuff DA, Kreamalmayer D, et al. Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science (New York, N.Y.). 360: 204-208. PMID 29650672 DOI: 10.1126/Science.Aar3799  0.428
2017 Lee S, Wilen CB, Orvedahl A, McCune BT, Kim KW, Orchard RC, Peterson ST, Nice TJ, Baldridge MT, Virgin HW. Norovirus Cell Tropism Is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine. Cell Host & Microbe. PMID 28966054 DOI: 10.1016/J.Chom.2017.08.021  0.421
2017 Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S. Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases. Cell Host & Microbe. PMID 28669671 DOI: 10.1016/J.Chom.2017.06.005  0.357
2016 Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YJ, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW. Discovery of a proteinaceous cellular receptor for a norovirus. Science (New York, N.Y.). PMID 27540007 DOI: 10.1126/Science.Aaf1220  0.431
2016 O'Brien M, Manches O, Wilen C, Gopal R, Huq R, Wu V, Sunseri N, Bhardwaj N. CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells. Plos Pathogens. 12: e1005553. PMID 27082754 DOI: 10.1371/Journal.Ppat.1005553  0.447
2016 Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, et al. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host & Microbe. 19: 311-322. PMID 26962942 DOI: 10.1016/J.Chom.2016.02.011  0.52
2016 Lu Q, Yokoyama CC, Williams JW, Baldridge MT, Jin X, DesRochers B, Bricker T, Wilen CB, Bagaitkar J, Loginicheva E, Sergushichev A, Kreamalmeyer D, Keller BC, Zhao Y, Kambal A, et al. Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host & Microbe. 19: 102-113. PMID 26764600 DOI: 10.1016/J.Chom.2015.12.011  0.33
2015 Gonzalez MD, Wilen CB, Burnham CA. Markers of intestinal inflammation for the diagnosis of infectious gastroenteritis. Clinics in Laboratory Medicine. 35: 333-44. PMID 26004646 DOI: 10.1016/J.Cll.2015.02.001  0.31
2015 Wilen CB, Monaco CL, Hoppe-Bauer J, Jackups R, Bucelli RC, Burnham CA. Criteria for reducing unnecessary testing for herpes simplex virus, varicella-zoster virus, cytomegalovirus, and enterovirus in cerebrospinal fluid samples from adults. Journal of Clinical Microbiology. 53: 887-95. PMID 25568435 DOI: 10.1128/Jcm.03161-14  0.332
2014 Petersen J, Drake MJ, Bruce EA, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K. The major cellular sterol regulatory pathway is required for Andes virus infection. Plos Pathogens. 10: e1003911. PMID 24516383 DOI: 10.1371/Journal.Ppat.1003911  0.706
2014 Didigu CA, Wilen CB, Wang J, Duong J, Secreto AJ, Danet-Desnoyers GA, Riley JL, Gregory PD, June CH, Holmes MC, Doms RW. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood. 123: 61-9. PMID 24162716 DOI: 10.1182/Blood-2013-08-521229  0.673
2013 Parrish NF, Gao F, Li H, Giorgi EE, Barbian HJ, Parrish EH, Zajic L, Iyer SS, Decker JM, Kumar A, Hora B, Berg A, Cai F, Hopper J, Denny TN, ... ... Wilen CB, et al. Phenotypic properties of transmitted founder HIV-1. Proceedings of the National Academy of Sciences of the United States of America. 110: 6626-33. PMID 23542380 DOI: 10.1073/Pnas.1304288110  0.683
2013 Parker ZF, Iyer SS, Wilen CB, Parrish NF, Chikere KC, Lee FH, Didigu CA, Berro R, Klasse PJ, Lee B, Moore JP, Shaw GM, Hahn BH, Doms RW. Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5. Journal of Virology. 87: 2401-11. PMID 23269796 DOI: 10.1128/Jvi.02964-12  0.676
2013 Parrish NF, Li H, Hora B, Berg A, Wilen CB, Decker J, Iyer SS, Zajic L, O’Brien M, Salazar-Gonzalez JF, Salazar MG, Parrish EH, Ding H, Kumar A, Ochsenbauer C, et al. C106 Distinguishing Features of Transmitted/Founder HIV-1 Jaids Journal of Acquired Immune Deficiency Syndromes. 62: S45. DOI: 10.1097/01.Qai.0000429225.92253.36  0.559
2012 Wilen CB, Tilton JC, Doms RW. HIV: cell binding and entry. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908191 DOI: 10.1101/Cshperspect.A006866  0.659
2012 Parrish NF, Wilen CB, Banks LB, Iyer SS, Pfaff JM, Salazar-Gonzalez JF, Salazar MG, Decker JM, Parrish EH, Berg A, Hopper J, Hora B, Kumar A, Mahlokozera T, Yuan S, et al. Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7 Plos Pathogens. 8. PMID 22693444 DOI: 10.1371/Journal.Ppat.1002686  0.688
2012 Wilen CB, Tilton JC, Doms RW. Molecular mechanisms of HIV entry. Advances in Experimental Medicine and Biology. 726: 223-42. PMID 22297516 DOI: 10.1007/978-1-4614-0980-9_10  0.653
2011 Jiang C, Parrish NF, Wilen CB, Li H, Chen Y, Pavlicek JW, Berg A, Lu X, Song H, Tilton JC, Pfaff JM, Henning EA, Decker JM, Moody MA, Drinker MS, et al. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism. Journal of Virology. 85: 10669-81. PMID 21835785 DOI: 10.1128/Jvi.05249-11  0.678
2011 Wilen CB, Parrish NF, Pfaff JM, Decker JM, Henning EA, Haim H, Petersen JE, Wojcechowskyj JA, Sodroski J, Haynes BF, Montefiori DC, Tilton JC, Shaw GM, Hahn BH, Doms RW. Phenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins. Journal of Virology. 85: 8514-27. PMID 21715507 DOI: 10.1128/Jvi.00736-11  0.713
2011 Wilen CB, Wang J, Tilton JC, Miller JC, Kim KA, Rebar EJ, Sherrill-Mix SA, Patro SC, Secreto AJ, Jordan AP, Lee G, Kahn J, Aye PP, Bunnell BA, Lackner AA, et al. Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases. Plos Pathogens. 7: e1002020. PMID 21533216 DOI: 10.1371/Journal.Ppat.1002020  0.674
2010 Tilton JC, Wilen CB, Didigu CA, Sinha R, Harrison JE, Agrawal-Gamse C, Henning EA, Bushman FD, Martin JN, Deeks SG, Doms RW. A maraviroc-resistant HIV-1 with narrow cross-resistance to other CCR5 antagonists depends on both N-terminal and extracellular loop domains of drug-bound CCR5. Journal of Virology. 84: 10863-76. PMID 20702642 DOI: 10.1128/Jvi.01109-10  0.656
2010 Pfaff JM, Wilen CB, Harrison JE, Demarest JF, Lee B, Doms RW, Tilton JC. HIV-1 resistance to CCR5 antagonists associated with highly efficient use of CCR5 and altered tropism on primary CD4+ T cells. Journal of Virology. 84: 6505-14. PMID 20410277 DOI: 10.1128/Jvi.00374-10  0.737
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