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Søren Brunak - Publications

Affiliations: 
Systems Biology Technical University of Denmark, Kongens Lyngby, Denmark 
Website:
http://www.cbs.dtu.dk/staff/show-staff.php?id=514
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Year Citation  Score
2020 Niss K, Gomez-Casado C, Hjaltelin JX, Joeris T, Agace WW, Belling KG, Brunak S. Complete Topological Mapping of a Cellular Protein Interactome Reveals Bow-Tie Motifs as Ubiquitous Connectors of Protein Complexes. Cell Reports. 31: 107763. PMID 32553166 DOI: 10.1016/J.Celrep.2020.107763  0.328
2019 Saunders G, Baudis M, Becker R, Beltran S, Béroud C, Birney E, Brooksbank C, Brunak S, Van den Bulcke M, Drysdale R, Capella-Gutierrez S, Flicek P, Florindi F, Goodhand P, Gut I, et al. Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews. Genetics. PMID 31455890 DOI: 10.1038/S41576-019-0156-9  0.316
2019 Hjaltelin JX, Izarzugaza JMG, Jensen LJ, Russo F, Westergaard D, Brunak S. Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types. Npj Systems Biology and Applications. 5: 27. PMID 31396397 DOI: 10.1038/s41540-019-0104-5  0.47
2019 Gådin JR, Buil A, Colantuoni C, Jaffe AE, Nielsen J, Shin JH, Hyde TM, Kleinman JE, Plath N, Eriksson P, Brunak S, Didriksen M, Weinberger DR, Folkersen L. Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq. Plos One. 14: e0217765. PMID 31206532 DOI: 10.1371/Journal.Pone.0217765  0.302
2019 Nielsen H, Tsirigos KD, Brunak S, von Heijne G. A Brief History of Protein Sorting Prediction. The Protein Journal. PMID 31119599 DOI: 10.1007/S10930-019-09838-3  0.313
2019 Aguayo-Orozco A, Taboureau O, Brunak S. The use of systems biology in chemical risk assessment Current Opinion in Toxicology. 15: 48-54. DOI: 10.1016/J.Cotox.2019.03.003  0.306
2018 Pedersen HK, Forslund SK, Gudmundsdottir V, Petersen AØ, Hildebrand F, Hyötyläinen T, Nielsen T, Hansen T, Bork P, Ehrlich SD, Brunak S, Oresic M, Pedersen O, Nielsen HB. A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links. Nature Protocols. PMID 30382244 DOI: 10.1038/S41596-018-0064-Z  0.489
2018 Fenoy E, Izarzugaza JMG, Jurtz V, Brunak S, Nielsen M. A generic Deep Convolutional Neural Network framework for prediction of Receptor-ligand Interactions. NetPhosPan; Application to Kinase Phosphorylation prediction. Bioinformatics (Oxford, England). PMID 30169744 DOI: 10.1093/Bioinformatics/Bty715  0.317
2018 Tsafou K, Katschnig AM, Radic-Sarikas B, Mutz CN, Iljin K, Schwentner R, Kauer MO, Mühlbacher K, Aryee DNT, Westergaard D, Haapa-Paananen S, Fey V, Superti-Furga G, Toretsky J, Brunak S, et al. Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers. Oncotarget. 9: 31018-31031. PMID 30123424 DOI: 10.18632/Oncotarget.25760  0.307
2018 Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, et al. Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery. PMID 29567993 DOI: 10.1038/Nrd.2018.52  0.503
2018 Jensen KH, Izarzugaza JMG, Juncker AS, Hansen RB, Hansen TF, Timshel P, Blondal T, Jensen TS, Rygaard-Hjalsted E, Mouritzen P, Thorsen M, Wernersson R, Nielsen HB, Jakobsen A, Brunak S, et al. Analysis of a gene panel for targeted sequencing of colorectal cancer samples. Oncotarget. 9: 9043-9060. PMID 29507673 DOI: 10.18632/Oncotarget.24138  0.308
2018 Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, et al. Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery. PMID 29472638 DOI: 10.1038/Nrd.2018.14  0.56
2018 Vanlandewijck M, Dadras MS, Lomnytska M, Mahzabin T, Lee Miller M, Busch C, Brunak S, Heldin CH, Moustakas A. The protein kinase SIK downregulates the polarity protein Par3. Oncotarget. 9: 5716-5735. PMID 29464029 DOI: 10.18632/Oncotarget.23788  0.314
2018 Westergaard D, Stærfeldt HH, Tønsberg C, Jensen LJ, Brunak S. A comprehensive and quantitative comparison of text-mining in 15 million full-text articles versus their corresponding abstracts. Plos Computational Biology. 14: e1005962. PMID 29447159 DOI: 10.1371/Journal.Pcbi.1005962  0.519
2018 Gudmundsdottir V, Pedersen HK, Allebrandt KV, Brorsson C, van Leeuwen N, Banasik K, Mahajan A, Groves CJ, van de Bunt M, Dawed AY, Fritsche A, Staiger H, Simonis-Bik AMC, Deelen J, Kramer MHH, ... ... Brunak S, et al. Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study. Plos One. 13: e0189886. PMID 29293525 DOI: 10.1371/Journal.Pone.0189886  0.307
2017 Russo F, Di Bella S, Vannini F, Berti G, Scoyni F, Cook HV, Santos A, Nigita G, Bonnici V, Laganà A, Geraci F, Pulvirenti A, Giugno R, De Masi F, Belling K, ... ... Brunak SR, et al. miRandola 2017: a curated knowledge base of non-invasive biomarkers. Nucleic Acids Research. PMID 29036351 DOI: 10.1093/Nar/Gkx854  0.504
2017 Kirk IK, Weinhold N, Brunak S, Belling K. The impact of the protein interactome on the syntenic structure of mammalian genomes. Plos One. 12: e0179112. PMID 28910296 DOI: 10.1371/Journal.Pone.0179112  0.37
2017 Maretty L, Jensen JM, Petersen B, Sibbesen JA, Liu S, Villesen P, Skov L, Belling K, Theil Have C, Izarzugaza JMG, Grosjean M, Bork-Jensen J, Grove J, Als TD, Huang S, ... ... Brunak S, et al. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference. Nature. PMID 28746312 DOI: 10.1038/Nature23264  0.326
2017 Pedersen HK, Gudmundsdottir V, Brunak S. Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes. Frontiers in Genetics. 8: 43. PMID 28473845 DOI: 10.3389/Fgene.2017.00043  0.358
2017 Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, ... ... Brunak S, et al. Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 545: 116. PMID 28470190 DOI: 10.1038/Nature22318  0.451
2017 Belling K, Russo F, Jensen AB, Dalgaard MD, Westergaard D, Rajpert-De Meyts E, Skakkebæk NE, Juul A, Brunak S. Klinefelter syndrome comorbidities linked to increased X chromosome gene dosage and altered protein interactome activity. Human Molecular Genetics. PMID 28369266 DOI: 10.1093/Hmg/Ddx014  0.348
2017 Folkersen L, Fauman E, Sabater-Lleal M, Strawbridge RJ, Frånberg M, Sennblad B, Baldassarre D, Veglia F, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, ... ... Brunak S, et al. Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. Plos Genetics. 13: e1006706. PMID 28369058 DOI: 10.1371/Journal.Pgen.1006706  0.351
2017 Francavilla C, Lupia M, Tsafou K, Villa A, Kowalczyk K, Rakownikow Jersie-Christensen R, Bertalot G, Confalonieri S, Brunak S, Jensen LJ, Cavallaro U, Olsen JV. Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer. Cell Reports. 18: 3242-3256. PMID 28355574 DOI: 10.1016/J.Celrep.2017.03.015  0.497
2017 Kirk IK, Weinhold N, Belling K, Skakkebæk NE, Jensen TS, Leffers H, Juul A, Brunak S. Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations. Cell Systems. PMID 28215527 DOI: 10.1016/J.Cels.2017.01.001  0.349
2016 Nguyen DT, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma'ayan A, Mandava G, Mani S, Mehta S, et al. Pharos: Collating protein information to shed light on the druggable genome. Nucleic Acids Research. PMID 27903890 DOI: 10.1093/Nar/Gkw1072  0.546
2016 Li T, Wernersson R, Hansen RB, Horn H, Mercer J, Slodkowicz G, Workman CT, Rigina O, Rapacki K, Stærfeldt HH, Brunak S, Jensen TS, Lage K. A scored human protein-protein interaction network to catalyze genomic interpretation. Nature Methods. PMID 27892958 DOI: 10.1038/Nmeth.4083  0.363
2016 Plichta DR, Juncker AS, Bertalan M, Rettedal E, Gautier L, Varela E, Manichanh C, Fouqueray C, Levenez F, Nielsen T, Doré J, Machado AM, de Evgrafov MC, Hansen T, Jørgensen T, ... ... Brunak S, et al. Transcriptional interactions suggest niche segregation among microorganisms in the human gut. Nature Microbiology. 1: 16152. PMID 27564131 DOI: 10.1038/Nmicrobiol.2016.152  0.44
2016 Hu JX, Thomas CE, Brunak S. Network biology concepts in complex disease comorbidities. Nature Reviews. Genetics. PMID 27498692 DOI: 10.1038/Nrg.2016.87  0.3
2016 Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, Forslund K, Hildebrand F, Prifti E, Falony G, Le Chatelier E, Levenez F, Doré J, Mattila I, Plichta DR, ... ... Brunak S, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature. PMID 27409811 DOI: 10.1038/Nature18646  0.415
2016 Pons T, Vazquez M, Matey-Hernandez ML, Brunak S, Valencia A, Izarzugaza JM. KinMutRF: a random forest classifier of sequence variants in the human protein kinase superfamily. Bmc Genomics. 17: 396. PMID 27357839 DOI: 10.1186/S12864-016-2723-1  0.359
2016 Friis-Nielsen J, Kjartansdóttir KR, Mollerup S, Asplund M, Mourier T, Jensen RH, Hansen TA, Rey-Iglesia A, Richter SR, Nielsen IB, Alquezar-Planas DE, Olsen PV, Vinner L, Fridholm H, Nielsen LP, ... ... Brunak S, et al. Identification of Known and Novel Recurrent Viral Sequences in Data from Multiple Patients and Multiple Cancers. Viruses. 8. PMID 26907326 DOI: 10.3390/v8020053  0.332
2016 Kringelum J, Kjaerulff SK, Brunak S, Lund O, Oprea TI, Taboureau O. ChemProt-3.0: a global chemical biology diseases mapping. Database : the Journal of Biological Databases and Curation. 2016. PMID 26876982 DOI: 10.1093/Database/Bav123  0.335
2015 Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Krogh Pedersen H, Arumugam M, Kristiansen K, Yvonne Voigt A, Vestergaard H, Hercog R, ... ... Brunak S, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. PMID 26633628 DOI: 10.1038/Nature15766  0.459
2015 Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Krogh Pedersen H, Arumugam M, Kristiansen K, Yvonne Voigt A, Vestergaard H, Hercog R, ... ... Brunak S, et al. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. PMID 26618873 DOI: 10.1038/nature15766  0.33
2015 Vazquez M, Pons T, Brunak S, Valencia A, Izarzugaza JM. wKinMut-2: Identification and Interpretation of Pathogenic Variants in Human Protein Kinases. Human Mutation. PMID 26443060 DOI: 10.1002/Humu.22914  0.374
2015 Vinner L, Mourier T, Friis-Nielsen J, Gniadecki R, Dybkaer K, Rosenberg J, Langhoff JL, Cruz DF, Fonager J, Izarzugaza JM, Gupta R, Sicheritz-Ponten T, Brunak S, Willerslev E, Nielsen LP, et al. Investigation of Human Cancers for Retrovirus by Low-Stringency Target Enrichment and High-Throughput Sequencing. Scientific Reports. 5: 13201. PMID 26285800 DOI: 10.1038/Srep13201  0.315
2015 Warrer P, Jensen PB, Aagaard L, Jensen LJ, Brunak S, Krag MH, Rossing P, Almdal T, Andersen HU, Hansen EH. Identification of possible adverse drug reactions in clinical notes: The case of glucose-lowering medicines. Journal of Research in Pharmacy Practice. 4: 64-72. PMID 25984543 DOI: 10.4103/2279-042X.155753  0.498
2015 Besenbacher S, Liu S, Izarzugaza JM, Grove J, Belling K, Bork-Jensen J, Huang S, Als TD, Li S, Yadav R, Rubio-García A, Lescai F, Demontis D, Rao J, Ye W, ... ... Brunak S, et al. Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios. Nature Communications. 6: 5969. PMID 25597990 DOI: 10.1038/Ncomms6969  0.303
2014 Eriksson R, Aagaard L, Jensen LJ, Borisova L, Hørlück D, Brunak S, Hansen EH. Discrepancies in listed adverse drug reactions in pharmaceutical product information supplied by the regulatory authorities in Denmark and the USA. Pharmacology Research & Perspectives. 2: e00038. PMID 25505588 DOI: 10.1002/Prp2.38  0.484
2014 Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Medicine. 6: 82. PMID 25473422 DOI: 10.1186/S13073-014-0082-6  0.326
2014 Malaspinas AS, Lao O, Schroeder H, Rasmussen M, Raghavan M, Moltke I, Campos PF, Sagredo FS, Rasmussen S, Gonçalves VF, Albrechtsen A, Allentoft ME, Johnson PL, Li M, Reis S, ... ... Brunak S, et al. Two ancient human genomes reveal Polynesian ancestry among the indigenous Botocudos of Brazil. Current Biology : Cb. 24: R1035-7. PMID 25455029 DOI: 10.1016/J.Cub.2014.09.078  0.313
2014 Re A, Workman CT, Waldron L, Quattrone A, Brunak S. Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells. Stem Cell Research. 13: 316-28. PMID 25173649 DOI: 10.1016/J.Scr.2014.07.008  0.33
2014 Nielsen HB, Almeida M, Juncker AS, Rasmussen S, Li J, Sunagawa S, Plichta DR, Gautier L, Pedersen AG, Le Chatelier E, Pelletier E, Bonde I, Nielsen T, Manichanh C, Arumugam M, ... ... Brunak S, et al. Identification and assembly of genomes and genetic elements in complex metagenomic samples without using reference genomes. Nature Biotechnology. 32: 822-8. PMID 24997787 DOI: 10.1038/Nbt.2939  0.494
2014 Li J, Jia H, Cai X, Zhong H, Feng Q, Sunagawa S, Arumugam M, Kultima JR, Prifti E, Nielsen T, Juncker AS, Manichanh C, Chen B, Zhang W, Levenez F, ... ... Brunak S, et al. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology. 32: 834-41. PMID 24997786 DOI: 10.1038/Nbt.2942  0.505
2014 Jensen AB, Moseley PL, Oprea TI, Ellesøe SG, Eriksson R, Schmock H, Jensen PB, Jensen LJ, Brunak S. Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients. Nature Communications. 5: 4022. PMID 24959948 DOI: 10.1038/Ncomms5022  0.491
2014 Lundby A, Rossin EJ, Steffensen AB, Acha MR, Newton-Cheh C, Pfeufer A, Lynch SN, Olesen SP, Brunak S, Ellinor PT, Jukema JW, Trompet S, Ford I, Macfarlane PW, et al. Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nature Methods. 11: 868-74. PMID 24952909 DOI: 10.1038/Nmeth.2997  0.323
2014 Eriksson R, Werge T, Jensen LJ, Brunak S. Dose-specific adverse drug reaction identification in electronic patient records: temporal data mining in an inpatient psychiatric population. Drug Safety. 37: 237-47. PMID 24634163 DOI: 10.1007/S40264-014-0145-Z  0.507
2014 Geertz-Hansen HM, Blom N, Feist AM, Brunak S, Petersen TN. Cofactory: sequence-based prediction of cofactor specificity of Rossmann folds. Proteins. 82: 1819-28. PMID 24523134 DOI: 10.1002/Prot.24536  0.302
2014 Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto J, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, ... ... Brunak S, et al. Addendum: Enterotypes of the human gut microbiome Nature. 506: 516-516. DOI: 10.1038/Nature13075  0.413
2013 Lohmueller KE, Sparsø T, Li Q, Andersson E, Korneliussen T, Albrechtsen A, Banasik K, Grarup N, Hallgrimsdottir I, Kiil K, Kilpeläinen TO, Krarup NT, Pers TH, Sanchez G, Hu Y, ... ... Brunak S, et al. Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. American Journal of Human Genetics. 93: 1072-86. PMID 24290377 DOI: 10.1016/J.Ajhg.2013.11.005  0.309
2013 Sunagawa S, Mende DR, Zeller G, Izquierdo-Carrasco F, Berger SA, Kultima JR, Coelho LP, Arumugam M, Tap J, Nielsen HB, Rasmussen S, Brunak S, Pedersen O, Guarner F, de Vos WM, et al. Metagenomic species profiling using universal phylogenetic marker genes. Nature Methods. 10: 1196-9. PMID 24141494 DOI: 10.1038/Nmeth.2693  0.476
2013 Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Brunak S, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, et al. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 155: 70-80. PMID 24074861 DOI: 10.1016/J.Cell.2013.08.030  0.511
2013 Audouze K, Brunak S, Grandjean P. A computational approach to chemical etiologies of diabetes. Scientific Reports. 3: 2712. PMID 24048418 DOI: 10.1038/Srep02712  0.333
2013 Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, Almeida M, Arumugam M, Batto JM, Kennedy S, Leonard P, Li J, Burgdorf K, Grarup N, Jørgensen T, ... ... Brunak S, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 500: 541-6. PMID 23985870 DOI: 10.1038/Nature12506  0.423
2013 Johansen MB, Izarzugaza JM, Brunak S, Petersen TN, Gupta R. Prediction of disease causing non-synonymous SNPs by the Artificial Neural Network Predictor NetDiseaseSNP. Plos One. 8: e68370. PMID 23935863 DOI: 10.1371/Journal.Pone.0068370  0.312
2013 Börnigen D, Pers TH, Thorrez L, Huttenhower C, Moreau Y, Brunak S. Concordance of gene expression in human protein complexes reveals tissue specificity and pathology. Nucleic Acids Research. 41: e171. PMID 23921638 DOI: 10.1093/Nar/Gkt661  0.317
2013 Orlando L, Ginolhac A, Zhang G, Froese D, Albrechtsen A, Stiller M, Schubert M, Cappellini E, Petersen B, Moltke I, Johnson PL, Fumagalli M, Vilstrup JT, Raghavan M, Korneliussen T, ... ... Brunak S, et al. Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse. Nature. 499: 74-8. PMID 23803765 DOI: 10.1038/Nature12323  0.522
2013 Eriksson R, Jensen PB, Frankild S, Jensen LJ, Brunak S. Dictionary construction and identification of possible adverse drug events in Danish clinical narrative text. Journal of the American Medical Informatics Association : Jamia. 20: 947-53. PMID 23703825 DOI: 10.1136/Amiajnl-2013-001708  0.492
2013 Pers TH, Dworzy?ski P, Thomas CE, Lage K, Brunak S. MetaRanker 2.0: a web server for prioritization of genetic variation data. Nucleic Acids Research. 41: W104-8. PMID 23703204 DOI: 10.1093/Nar/Gkt387  0.344
2013 Edsgärd D, Dalgaard MD, Weinhold N, Wesolowska-Andersen A, Rajpert-De Meyts E, Ottesen AM, Juul A, Skakkebæk NE, Skøt Jensen T, Gupta R, Leffers H, Brunak S. Genome-wide assessment of the association of rare and common copy number variations to testicular germ cell cancer. Frontiers in Endocrinology. 4: 2. PMID 23372565 DOI: 10.3389/Fendo.2013.00002  0.324
2013 Jensen PB, Jensen LJ, Brunak S. Reply to 'Mining electronic health records: an additional perspective'. Nature Reviews. Genetics. 14: 75. PMID 23247438 DOI: 10.1038/Nrg3208-C2  0.452
2013 Kim Kjærulff S, Wich L, Kringelum J, Jacobsen UP, Kouskoumvekaki I, Audouze K, Lund O, Brunak S, Oprea TI, Taboureau O. ChemProt-2.0: visual navigation in a disease chemical biology database. Nucleic Acids Research. 41: D464-9. PMID 23185041 DOI: 10.1093/Nar/Gks1166  0.348
2012 Jensen PB, Jensen LJ, Brunak S. Mining electronic health records: towards better research applications and clinical care. Nature Reviews. Genetics. 13: 395-405. PMID 22549152 DOI: 10.1038/Nrg3208  0.496
2012 Rojas AM, Santamaria A, Malik R, Jensen TS, Körner R, Morilla I, de Juan D, Krallinger M, Hansen DA, Hoffmann R, Lees J, Reid A, Yeats C, Wehner A, Elowe S, ... ... Brunak S, et al. Uncovering the molecular machinery of the human spindle--an integration of wet and dry systems biology. Plos One. 7: e31813. PMID 22427808 DOI: 10.1371/Journal.Pone.0031813  0.359
2012 Dalgaard MD, Weinhold N, Edsgärd D, Silver JD, Pers TH, Nielsen JE, Jørgensen N, Juul A, Gerds TA, Giwercman A, Giwercman YL, Cohn-Cedermark G, Virtanen HE, Toppari J, Daugaard G, ... ... Brunak S, et al. A genome-wide association study of men with symptoms of testicular dysgenesis syndrome and its network biology interpretation. Journal of Medical Genetics. 49: 58-65. PMID 22140272 DOI: 10.1136/Jmedgenet-2011-100174  0.334
2011 Wang K, Wernersson R, Brunak S. The strength of intron donor splice sites in human genes displays a bell-shaped pattern. Bioinformatics (Oxford, England). 27: 3079-84. PMID 21994226 DOI: 10.1093/Bioinformatics/Btr532  0.311
2011 Roque FS, Jensen PB, Schmock H, Dalgaard M, Andreatta M, Hansen T, Søeby K, Bredkjær S, Juul A, Werge T, Jensen LJ, Brunak S. Using electronic patient records to discover disease correlations and stratify patient cohorts. Plos Computational Biology. 7: e1002141. PMID 21901084 DOI: 10.1371/Journal.Pcbi.1002141  0.503
2011 Jensen MK, Pers TH, Dworzynski P, Girman CJ, Brunak S, Rimm EB. Protein interaction-based genome-wide analysis of incident coronary heart disease. Circulation. Cardiovascular Genetics. 4: 549-56. PMID 21880673 DOI: 10.1161/Circgenetics.111.960393  0.353
2011 Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J. Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 108: E681-8. PMID 21705657 DOI: 10.1073/Pnas.1104384108  0.334
2011 Edsgärd D, Scheel M, Hansen NT, Ralfkiaer U, Jensen TS, Skakkebaek NE, Brunak S, Gupta R, Rajpert-De Meyts E, Ottesen AM. Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information. International Journal of Andrology. 34: e122-32. PMID 21696394 DOI: 10.1111/J.1365-2605.2011.01188.X  0.31
2011 Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, Fernandes GR, Tap J, Bruls T, Batto JM, Bertalan M, Borruel N, Casellas F, Fernandez L, Gautier L, ... ... Brunak S, et al. Enterotypes of the human gut microbiome. Nature. 473: 174-80. PMID 21508958 DOI: 10.1038/Nature09944  0.473
2011 Pers TH, Hansen NT, Lage K, Koefoed P, Dworzynski P, Miller ML, Flint TJ, Mellerup E, Dam H, Andreassen OA, Djurovic S, Melle I, Børglum AD, Werge T, Purcell S, ... ... Brunak S, et al. Meta-analysis of heterogeneous data sources for genome-scale identification of risk genes in complex phenotypes. Genetic Epidemiology. 35: 318-32. PMID 21484861 DOI: 10.1002/Gepi.20580  0.377
2011 Wesolowska A, Dalgaard MD, Borst L, Gautier L, Bak M, Weinhold N, Nielsen BF, Helt LR, Audouze K, Nersting J, Tommerup N, Brunak S, Sicheritz-Ponten T, Leffers H, Schmiegelow K, et al. Cost-effective multiplexing before capture allows screening of 25 000 clinically relevant SNPs in childhood acute lymphoblastic leukemia. Leukemia. 25: 1001-6. PMID 21415851 DOI: 10.1038/Leu.2011.32  0.311
2011 Banasik K, Justesen JM, Hornbak M, Krarup NT, Gjesing AP, Sandholt CH, Jensen TS, Grarup N, Andersson A, Jørgensen T, Witte DR, Sandbæk A, Lauritzen T, Thorens B, Brunak S, et al. Bioinformatics-driven identification and examination of candidate genes for non-alcoholic fatty liver disease. Plos One. 6: e16542. PMID 21339799 DOI: 10.1371/Journal.Pone.0016542  0.332
2011 Taboureau O, Nielsen SK, Audouze K, Weinhold N, Edsgärd D, Roque FS, Kouskoumvekaki I, Bora A, Curpan R, Jensen TS, Brunak S, Oprea TI. ChemProt: a disease chemical biology database. Nucleic Acids Research. 39: D367-72. PMID 20935044 DOI: 10.1093/Nar/Gkq906  0.345
2010 Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, ... ... Brunak S, et al. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Molecular Systems Biology. 6: 381. PMID 20571530 DOI: 10.1038/Msb.2010.36  0.319
2010 Audouze K, Juncker AS, Roque FJ, Krysiak-Baltyn K, Weinhold N, Taboureau O, Jensen TS, Brunak S. Deciphering diseases and biological targets for environmental chemicals using toxicogenomics networks. Plos Computational Biology. 6: e1000788. PMID 20502671 DOI: 10.1371/Journal.Pcbi.1000788  0.327
2010 Blicher T, Gupta R, Wesolowska A, Jensen LJ, Brunak S. Protein annotation in the era of personal genomics. Current Opinion in Structural Biology. 20: 335-41. PMID 20403684 DOI: 10.1016/J.Sbi.2010.03.008  0.546
2010 Brorsson C, Tue Hansen N, Bergholdt R, Brunak S, Pociot F. The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes. Plos One. 5: e9576. PMID 20221424 DOI: 10.1371/Journal.Pone.0009576  0.33
2010 Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, Mende DR, Li J, Xu J, Li S, Li D, ... ... Brunak S, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464: 59-65. PMID 20203603 DOI: 10.1038/Nature08821  0.492
2010 Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, Metspalu M, Metspalu E, Kivisild T, Gupta R, Bertalan M, Nielsen K, Gilbert MT, Wang Y, Raghavan M, ... ... Brunak S, et al. Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 463: 757-62. PMID 20148029 DOI: 10.1038/Nature08835  0.315
2010 Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Science Signaling. 3: ra3. PMID 20068231 DOI: 10.1126/Scisignal.2000475  0.525
2010 Gauthier NP, Jensen LJ, Wernersson R, Brunak S, Jensen TS. Cyclebase.org: version 2.0, an updated comprehensive, multi-species repository of cell cycle experiments and derived analysis results. Nucleic Acids Research. 38: D699-702. PMID 19934261 DOI: 10.1093/Nar/Gkp1044  0.543
2010 Wesolowska A, Dalgaard MD, Borst L, Gautier L, Bak M, Weinhold N, Nielsen BF, Nersting J, Tommerup N, Brunak S, Ponten TS, Leffers H, Schmiegelow K, Gupta R. Relating genomic variation to drug response in childhood acute lymphoblastic leukemia by multiplexed targeted sequencing Genome Biology. 11: 41. DOI: 10.1186/Gb-2010-11-S1-P41  0.324
2009 Juncker AS, Larsen MV, Weinhold N, Nielsen M, Brunak S, Lund O. Systematic characterisation of cellular localisation and expression profiles of proteins containing MHC ligands. Plos One. 4: e7448. PMID 19826487 DOI: 10.1371/Journal.Pone.0007448  0.3
2009 Bergholdt R, Brorsson C, Lage K, Nielsen JH, Brunak S, Pociot F. Expression profiling of human genetic and protein interaction networks in type 1 diabetes. Plos One. 4: e6250. PMID 19609442 DOI: 10.1371/Journal.Pone.0006250  0.348
2009 Hansen NT, Brunak S, Altman RB. Generating genome-scale candidate gene lists for pharmacogenomics. Clinical Pharmacology and Therapeutics. 86: 183-9. PMID 19369935 DOI: 10.1038/Clpt.2009.42  0.321
2009 Juncker AS, Jensen LJ, Pierleoni A, Bernsel A, Tress ML, Bork P, von Heijne G, Valencia A, Ouzounis CA, Casadio R, Brunak S. Sequence-based feature prediction and annotation of proteins. Genome Biology. 10: 206. PMID 19226438 DOI: 10.1186/Gb-2009-10-2-206  0.634
2009 Brorsson C, Hansen NT, Lage K, Bergholdt R, Brunak S, Pociot F. Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data. Diabetes, Obesity & Metabolism. 11: 60-6. PMID 19143816 DOI: 10.1111/J.1463-1326.2008.01004.X  0.352
2009 Wang K, Ussery DW, Brunak S. Analysis and prediction of gene splice sites in four Aspergillus genomes. Fungal Genetics and Biology : Fg & B. 46: S14-8. PMID 18948220 DOI: 10.1016/J.Fgb.2008.09.010  0.362
2008 Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, ... ... Brunak S, et al. Linear motif atlas for phosphorylation-dependent signaling. Science Signaling. 1: ra2. PMID 18765831 DOI: 10.1126/Scisignal.1159433  0.593
2008 Jensen LJ, de Lichtenberg U, Jensen TS, Brunak S, Bork P. Circular reasoning rather than cyclic expression. Genome Biology. 9: 403. PMID 18598377 DOI: 10.1186/Gb-2008-9-6-403  0.578
2008 Spicker JS, Brunak S, Frederiksen KS, Toft H. Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation. Toxicological Sciences : An Official Journal of the Society of Toxicology. 102: 444-54. PMID 18178960 DOI: 10.1093/Toxsci/Kfn001  0.3
2008 Gauthier NP, Larsen ME, Wernersson R, de Lichtenberg U, Jensen LJ, Brunak S, Jensen TS. Cyclebase.org--a comprehensive multi-organism online database of cell-cycle experiments. Nucleic Acids Research. 36: D854-9. PMID 17940094 DOI: 10.1093/Nar/Gkm729  0.535
2008 Lamberth K, Nielsen M, Lundegaard C, Worning P, Laurmøller SL, Lund O, Brunak S, Buus S. ‘Query-by Committee’- An Efficient Method to Select Information-Rich Data for the Development of Peptide-HLA-Binding Predictors Scandinavian Journal of Immunology. 59: 633-633. DOI: 10.1111/J.0300-9475.2004.01423Bf.X  0.316
2008 Jensen LJ, Lichtenberg Ud, Jensen TS, Brunak S, Bork P. Just-in-time assembly of cell-cycle protein complexes Nature Precedings. DOI: 10.1038/Npre.2008.2273.1  0.446
2007 Bergholdt R, Størling ZM, Lage K, Karlberg EO, Olason PI, Aalund M, Nerup J, Brunak S, Workman CT, Pociot F. Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biology. 8: R253. PMID 18045462 DOI: 10.1186/Gb-2007-8-11-R253  0.336
2007 de Lichtenberg U, Jensen TS, Brunak S, Bork P, Jensen LJ. Evolution of cell cycle control: same molecular machines, different regulation. Cell Cycle (Georgetown, Tex.). 6: 1819-25. PMID 17671420 DOI: 10.4161/Cc.6.15.4537  0.612
2007 Spicker JS, Pedersen HT, Nielsen HB, Brunak S. Analysis of cell death inducing compounds. Archives of Toxicology. 81: 803-11. PMID 17503021 DOI: 10.1007/S00204-007-0207-4  0.317
2007 Emanuelsson O, Brunak S, von Heijne G, Nielsen H. Locating proteins in the cell using TargetP, SignalP and related tools. Nature Protocols. 2: 953-71. PMID 17446895 DOI: 10.1038/Nprot.2007.131  0.357
2007 Gorodkin J, Cirera S, Hedegaard J, Gilchrist MJ, Panitz F, Jørgensen C, Scheibye-Knudsen K, Arvin T, Lumholdt S, Sawera M, Green T, Nielsen BJ, Havgaard JH, Rosenkilde C, Wang J, ... ... Brunak S, et al. Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags. Genome Biology. 8: R45. PMID 17407547 DOI: 10.1186/Gb-2007-8-4-R45  0.323
2007 Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C, Olason PI, Albrecht M, Hegyi H, Giorgetti A, Raimondo D, Lagarde J, Laskowski RA, López G, Sadowski MI, ... ... Brunak S, et al. The implications of alternative splicing in the ENCODE protein complement. Proceedings of the National Academy of Sciences of the United States of America. 104: 5495-500. PMID 17372197 DOI: 10.1073/Pnas.0700800104  0.34
2007 Lage K, Karlberg EO, Størling ZM, Olason PI, Pedersen AG, Rigina O, Hinsby AM, Tümer Z, Pociot F, Tommerup N, Moreau Y, Brunak S. A human phenome-interactome network of protein complexes implicated in genetic disorders. Nature Biotechnology. 25: 309-16. PMID 17344885 DOI: 10.1038/Nbt1295  0.345
2006 Rapin N, Kesmir C, Frankild S, Nielsen M, Lundegaard C, Brunak S, Lund O. Modelling the human immune system by combining bioinformatics and systems biology approaches. Journal of Biological Physics. 32: 335-53. PMID 19669470 DOI: 10.1007/S10867-006-9019-7  0.321
2006 Jensen LJ, Jensen TS, de Lichtenberg U, Brunak S, Bork P. Co-evolution of transcriptional and post-translational cell-cycle regulation. Nature. 443: 594-7. PMID 17006448 DOI: 10.1038/Nature05186  0.62
2006 Johansen MB, Kiemer L, Brunak S. Analysis and prediction of mammalian protein glycation. Glycobiology. 16: 844-53. PMID 16762979 DOI: 10.1093/Glycob/Cwl009  0.311
2006 Hinsby AM, Kiemer L, Karlberg EO, Lage K, Fausbøll A, Juncker AS, Andersen JS, Mann M, Brunak S. A wiring of the human nucleolus. Molecular Cell. 22: 285-95. PMID 16630896 DOI: 10.1016/J.Molcel.2006.03.012  0.356
2005 de Lichtenberg U, Wernersson R, Jensen TS, Nielsen HB, Fausbøll A, Schmidt P, Hansen FB, Knudsen S, Brunak S. New weakly expressed cell cycle-regulated genes in yeast. Yeast (Chichester, England). 22: 1191-201. PMID 16278933 DOI: 10.1002/Yea.1302  0.307
2005 Bendtsen JD, Kiemer L, Fausbøll A, Brunak S. Non-classical protein secretion in bacteria. Bmc Microbiology. 5: 58. PMID 16212653 DOI: 10.1186/1471-2180-5-58  0.346
2005 Wernersson R, Schierup MH, Jørgensen FG, Gorodkin J, Panitz F, Staerfeldt HH, Christensen OF, Mailund T, Hornshøj H, Klein A, Wang J, Liu B, Hu S, Dong W, Li W, ... ... Brunak S, et al. Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing. Bmc Genomics. 6: 70. PMID 15885146 DOI: 10.1186/1471-2164-6-70  0.328
2005 de Lichtenberg U, Jensen LJ, Brunak S, Bork P. Dynamic complex formation during the yeast cell cycle. Science (New York, N.Y.). 307: 724-7. PMID 15692050 DOI: 10.1126/Science.1105103  0.611
2005 de Lichtenberg U, Jensen LJ, Fausbøll A, Jensen TS, Bork P, Brunak S. Comparison of computational methods for the identification of cell cycle-regulated genes. Bioinformatics (Oxford, England). 21: 1164-71. PMID 15513999 DOI: 10.1093/Bioinformatics/Bti093  0.612
2005 Julenius K, Mølgaard A, Gupta R, Brunak S. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites Glycobiology. 15: 153-164. PMID 15385431 DOI: 10.1093/Glycob/Cwh151  0.332
2004 La Cour T, Kiemer L, Mølgaard A, Gupta R, Skriver K, Brunak S. Analysis and prediction of leucine-rich nuclear export signals Protein Engineering, Design and Selection. 17: 527-536. PMID 15314210 DOI: 10.1093/Protein/Gzh062  0.327
2004 Hjerrild M, Stensballe A, Rasmussen TE, Kofoed CB, Blom N, Sicheritz-Ponten T, Larsen MR, Brunak S, Jensen ON, Gammeltoft S. Identification of phosphorylation sites in protein kinase A substrates using artificial neural networks and mass spectrometry. Journal of Proteome Research. 3: 426-33. PMID 15253423 DOI: 10.1021/Pr0341033  0.302
2004 Bendtsen JD, Nielsen H, von Heijne G, Brunak S. Improved prediction of signal peptides: SignalP 3.0. Journal of Molecular Biology. 340: 783-95. PMID 15223320 DOI: 10.1016/J.Jmb.2004.05.028  0.307
2004 Kiemer L, Lund O, Brunak S, Blom N. Coronavirus 3CLpro proteinase cleavage sites: Possible relevance to SARS virus pathology Bmc Bioinformatics. 5. PMID 15180906 DOI: 10.1186/1471-2105-5-72  0.353
2004 Blom N, Sicheritz-Pontén T, Gupta R, Gammeltoft S, Brunak S. Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence. Proteomics. 4: 1633-49. PMID 15174133 DOI: 10.1002/Pmic.200300771  0.343
2004 Bendtsen JD, Jensen LJ, Blom N, Von Heijne G, Brunak S. Feature-based prediction of non-classical and leaderless protein secretion. Protein Engineering, Design & Selection : Peds. 17: 349-56. PMID 15115854 DOI: 10.1093/Protein/Gzh037  0.547
2004 Duckert P, Brunak S, Blom N. Prediction of proprotein convertase cleavage sites Protein Engineering, Design and Selection. 17: 107-112. PMID 14985543 DOI: 10.1093/Protein/Gzh013  0.322
2004 Eden E, Brunak S. Analysis and recognition of 5′ UTR intron splice sites in human pre-mRNA Nucleic Acids Research. 32: 1131-1142. PMID 14960723 DOI: 10.1093/Nar/Gkh273  0.306
2004 Andersen CAF, Brunak S. Representation of Protein-Sequence Information by Amino Acid Subalphabets Ai Magazine. 25: 97-104. DOI: 10.1609/Aimag.V25I1.1750  0.348
2003 Jensen LJ, Ussery DW, Brunak S. Functionality of system components: conservation of protein function in protein feature space. Genome Research. 13: 2444-9. PMID 14559779 DOI: 10.1101/Gr.1190803  0.55
2003 Juncker AS, Willenbrock H, Von Heijne G, Brunak S, Nielsen H, Krogh A. Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Science : a Publication of the Protein Society. 12: 1652-62. PMID 12876315 DOI: 10.1110/Ps.0303703  0.336
2003 Saxová P, Buus S, Brunak S, Keşmir C. Predicting proteasomal cleavage sites: A comparison of available methods International Immunology. 15: 781-787. PMID 12807816 DOI: 10.1093/Intimm/Dxg084  0.308
2003 de Lichtenberg U, Jensen TS, Jensen LJ, Brunak S. Protein feature based identification of cell cycle regulated proteins in yeast. Journal of Molecular Biology. 329: 663-74. PMID 12787668 DOI: 10.1016/S0022-2836(03)00490-X  0.553
2003 Nielsen M, Lundegaard C, Worning P, Lauemøller SL, Lamberth K, Buus S, Brunak S, Lund O. Reliable prediction of T-cell epitopes using neural networks with novel sequence representations Protein Science. 12: 1007-1017. PMID 12717023 DOI: 10.1110/Ps.0239403  0.315
2003 Jensen LJ, Gupta R, Staerfeldt HH, Brunak S. Prediction of human protein function according to Gene Ontology categories. Bioinformatics (Oxford, England). 19: 635-42. PMID 12651722 DOI: 10.1093/Bioinformatics/Btg036  0.576
2002 Jensen LJ, Skovgaard M, Brunak S. Prediction of novel archaeal enzymes from sequence-derived features. Protein Science : a Publication of the Protein Society. 11: 2894-8. PMID 12441387 DOI: 10.1110/Ps.0225102  0.542
2002 Workman C, Jensen LJ, Jarmer H, Berka R, Gautier L, Nielser HB, Saxild HH, Nielsen C, Brunak S, Knudsen S. A new non-linear normalization method for reducing variability in DNA microarray experiments. Genome Biology. 3: research0048. PMID 12225587 DOI: 10.1186/Gb-2002-3-9-Research0048  0.503
2002 Jensen LJ, Gupta R, Blom N, Devos D, Tamames J, Kesmir C, Nielsen H, Staerfeldt HH, Rapacki K, Workman C, Andersen CA, Knudsen S, Krogh A, Valencia A, Brunak S. Prediction of human protein function from post-translational modifications and localization features. Journal of Molecular Biology. 319: 1257-65. PMID 12079362 DOI: 10.1016/S0022-2836(02)00379-0  0.549
2002 Gupta R, Jensen LJ, Brunak S. Orphan protein function and its relation to glycosylation. Ernst Schering Research Foundation Workshop. 276-94. PMID 12061006  0.441
2002 Skovgaard M, Jensen LJ, Friis C, Stærfeldt HH, Worning P, Brunak S, Ussery D. The Atlas visualization of genomewide information Methods in Microbiology. 33: 49-63. DOI: 10.1016/S0580-9517(02)33004-6  0.502
2001 Skovgaard M, Jensen LJ, Brunak S, Ussery D, Krogh A. On the total number of genes and their length distribution in complete microbial genomes. Trends in Genetics : Tig. 17: 425-8. PMID 11485798 DOI: 10.1016/S0168-9525(01)02372-1  0.541
2001 Ussery D, Larsen TS, Wilkes KT, Friis C, Worning P, Krogh A, Brunak S. Genome organisation and chromatin structure in Escherichia coli. Biochimie. 83: 201-12. PMID 11278070 DOI: 10.1016/S0300-9084(00)01225-6  0.315
2000 Petersen TN, Lundegaard C, Nielsen M, Bohr H, Bohr J, Brunak S, Gippert GP, Lund O. Prediction of protein secondary structure at 80% accuracy Proteins: Structure, Function and Genetics. 41: 17-20. PMID 10944389 DOI: 10.1002/1097-0134(20001001)41:1<17::Aid-Prot40>3.0.Co;2-F  0.307
2000 Emanuelsson O, Nielsen H, Brunak S, Von Heijne G. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence Journal of Molecular Biology. 300: 1005-1016. PMID 10891285 DOI: 10.1006/Jmbi.2000.3903  0.342
2000 Pedersen AG, Jensen LJ, Brunak S, Staerfeldt HH, Ussery DW. A DNA structural atlas for Escherichia coli. Journal of Molecular Biology. 299: 907-30. PMID 10843847 DOI: 10.1006/Jmbi.2000.3787  0.517
2000 Worning P, Jensen LJ, Nelson KE, Brunak S, Ussery DW. Structural analysis of DNA sequence: evidence for lateral gene transfer in Thermotoga maritima. Nucleic Acids Research. 28: 706-9. PMID 10637321 DOI: 10.1093/Nar/28.3.706  0.537
1999 Blom N, Gammeltoft S, Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites Journal of Molecular Biology. 294: 1351-1362. PMID 10600390 DOI: 10.1006/Jmbi.1999.3310  0.327
1999 Gupta R, Jung E, Gooley AA, Williams KL, Brunak S, Hansen J. Scanning the available Dictyostelium discoideum proteome for O-linked GlcNAc glycosylation sites using neural networks Glycobiology. 9: 1009-1022. PMID 10521537 DOI: 10.1093/Glycob/9.10.1009  0.325
1999 Pedersen AG, Baldi P, Chauvin Y, Brunak S. The biology of eukaryotic promoter prediction - A review Computers and Chemistry. 23: 191-207. PMID 10404615 DOI: 10.1016/S0097-8485(99)00015-7  0.306
1999 Nielsen H, Brunak S, Von Heijne G. Machine learning approaches for the prediction of signal peptides and other protein sorting signals Protein Engineering. 12: 3-9. PMID 10065704 DOI: 10.1093/Protein/12.1.3  0.316
1999 Kreegipuu A, Blom N, Brunak S. PhosphoBase, a database of phosphorylation sites: Release 2.0 Nucleic Acids Research. 27: 237-239. PMID 9847189 DOI: 10.1093/Nar/27.1.237  0.301
1998 Østergaard L, Pedersen AG, Jespersen HM, Brunak S, Welinder KG. Computational analyses and annotations of the Arabidopsis peroxidase gene family Febs Letters. 433: 98-102. PMID 9738941 DOI: 10.1016/S0014-5793(98)00849-7  0.329
1998 Kreegipuu A, Blom N, Brunak S, Järv J. Statistical analysis of protein kinase specificity determinants Febs Letters. 430: 45-50. PMID 9678592 DOI: 10.1016/S0014-5793(98)00503-1  0.32
1998 Blom N, Kreegipuu A, Brunak S. PhosphoBase: A database of phosphorylation sites Nucleic Acids Research. 26: 382-386. PMID 9399879 DOI: 10.1093/Nar/26.1.382  0.31
1997 Nielsen H, Engelbrecht J, Brunak S, von Heijne G. A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites International Journal of Neural Systems. 8: 581-599. PMID 10065837 DOI: 10.1142/S0129065797000537  0.318
1997 Lund O, Frimand K, Gorodkin J, Bohr H, Bohr J, Hansen J, Brunak S. Protein distance constraints predicted by neural networks and probability density functions Protein Engineering. 10: 1241-1248. PMID 9514112 DOI: 10.1093/Protein/10.11.1241  0.322
1997 Claros MG, Brunak S, Heijne GV. Prediction of N-terminal protein sorting signals Current Opinion in Structural Biology. 7: 394-398. PMID 9204282 DOI: 10.1016/S0959-440X(97)80057-7  0.321
1997 Nielsen H, Engelbrecht J, Brunak S, von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Engineering. 10: 1-6. PMID 9051728 DOI: 10.1093/Protein/10.1.1  0.316
1997 Blom N, Hansen J, Blaas D, Brunak S. Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks. Protein Science : a Publication of the Protein Society. 5: 2203-16. PMID 8931139 DOI: 10.1002/Pro.5560051107  0.326
1997 Bohr H, Brunak S. Distance-based approaches to protein structure determination III (Copenhagen, Denmark, 5-8 November 1996) - Introductory overview Folding and Design. 2: S1-S2. DOI: 10.1016/S1359-0278(97)00054-0  0.32
1996 Baldi P, Brunak S, Chauvin Y, Krogh A. Naturally occurring nucleosome positioning signals in human exons and introns Journal of Molecular Biology. 263: 503-510. PMID 8918932 DOI: 10.1006/Jmbi.1996.0592  0.323
1996 Nielsen H, Engelbrecht J, von Heijne G, Brunak S. Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site. Proteins. 24: 165-77. PMID 8820484 DOI: 10.1002/(Sici)1097-0134(199602)24:2<165::Aid-Prot4>3.0.Co;2-I  0.332
1996 Brunak S, Engelbrecht J. Protein structure and the sequential structure of mRNA: alpha-helix and beta-sheet signals at the nucleotide level. Proteins. 25: 237-52. PMID 8811739 DOI: 10.1002/(Sici)1097-0134(199606)25:2<237::Aid-Prot9>3.0.Co;2-E  0.318
1996 Hebsgaard SM, Korning PG, Tolstrup N, Engelbrecht J, Rouzé P, Brunak S. Splice site prediction in Arabidopsis thaliana pre-mRNA by combining local and global sequence information. Nucleic Acids Research. 24: 3439-52. PMID 8811101 DOI: 10.1093/Nar/24.17.3439  0.322
1995 Larsen NI, Engelbrecht J, Brunak S. Analysis of eukaryotic promoter sequences reveals a systematically occurring CT-signal. Nucleic Acids Research. 23: 1223-30. PMID 7739901 DOI: 10.1093/Nar/23.7.1223  0.302
1993 Bohr J, Bohr H, Brunak S, Cotterill RM, Fredholm H, Lautrup B, Petersen SB. Protein structures from distance inequalities. Journal of Molecular Biology. 231: 861-9. PMID 7685827 DOI: 10.1006/Jmbi.1993.1332  0.3
1992 Engelbrecht J, Knudsen S, Brunak S. G+C-rich tract in 5' end of human introns. Journal of Molecular Biology. 227: 108-13. PMID 1522582 DOI: 10.1016/0022-2836(92)90685-D  0.31
Low-probability matches (unlikely to be authored by this person)
2011 Li Q, Eklund AC, Birkbak NJ, Desmedt C, Haibe-Kains B, Sotiriou C, Symmans WF, Pusztai L, Brunak S, Richardson AL, Szallasi Z. Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response. Bmc Bioinformatics. 12: 310. PMID 21798043 DOI: 10.1186/1471-2105-12-310  0.299
2016 Orozco AA, Audouze K, Brunak S, Taboureau O. In silico systems pharmacology to assess drug's therapeutic and toxic effects. Current Pharmaceutical Design. PMID 27604605 DOI: 10.2174/1381612822666160907093215  0.298
1996 Korning PG, Hebsgaard SM, Rouze P, Brunak S. Cleaning the GenBank Arabidopsis thaliana data set. Nucleic Acids Research. 24: 316-20. PMID 8628656 DOI: 10.1093/Nar/24.2.316  0.297
2019 Mollerup S, Asplund M, Friis-Nielsen J, Kjartansdóttir KR, Fridholm H, Hansen TA, Herrera JAR, Barnes CJ, Jensen RH, Richter SR, Nielsen IB, Pietroni C, Alquezar-Planas DE, Rey-Iglesia A, Olsen PVS, ... ... Brunak S, et al. High-throughput sequencing-based investigation of viruses in human cancers by multi-enrichment approach. The Journal of Infectious Diseases. PMID 31253993 DOI: 10.1093/Infdis/Jiz318  0.297
2008 Brorsson C, Hansen N, Lage K, Bergholdt R, Brunak S, Pociot F. Sa.79. Identification of T1D Genes in the MHC Region by a Novel Approach Combining Genetic Data with Information on Functional Pathways Clinical Immunology. 127: S106. DOI: 10.1016/J.Clim.2008.03.300  0.297
2014 Rasmussen M, Anzick SL, Waters MR, Skoglund P, DeGiorgio M, Stafford TW, Rasmussen S, Moltke I, Albrechtsen A, Doyle SM, Poznik GD, Gudmundsdottir V, Yadav R, Malaspinas AS, White SS, ... ... Brunak S, et al. The genome of a Late Pleistocene human from a Clovis burial site in western Montana. Nature. 506: 225-9. PMID 24522598 DOI: 10.1038/Nature13025  0.297
2012 Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segrè AV, Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG, et al. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proceedings of the National Academy of Sciences of the United States of America. 109: 14035-40. PMID 22904188 DOI: 10.1073/Pnas.1210730109  0.297
2018 Winge SB, Dalgaard MD, Belling KG, Jensen JM, Nielsen JE, Aksglaede L, Schierup MH, Brunak S, Skakkebæk NE, Juul A, Rajpert-De Meyts E, Almstrup K. Transcriptome analysis of the adult human Klinefelter testis and cellularity-matched controls reveals disturbed differentiation of Sertoli- and Leydig cells. Cell Death & Disease. 9: 586. PMID 29789566 DOI: 10.1038/S41419-018-0671-1  0.296
1988 Bohr H, Bohr J, Brunak S, Cotterill RM, Lautrup B, Nørskov L, Olsen OH, Petersen SB. Protein secondary structure and homology by neural networks. The alpha-helices in rhodopsin. Febs Letters. 241: 223-8. PMID 3197832 DOI: 10.1016/0014-5793(88)81066-4  0.296
2005 Larsen MV, Lundegaard C, Lamberth K, Buus S, Brunak S, Lund O, Nielsen M. An integrative approach to CTL epitope prediction: a combined algorithm integrating MHC class I binding, TAP transport efficiency, and proteasomal cleavage predictions. European Journal of Immunology. 35: 2295-303. PMID 15997466 DOI: 10.1002/Eji.200425811  0.296
2003 Lundegaard C, Petersen TN, Nielsen M, Bohr H, Bohr J, Brunak S, Gippert C, Lund O. Prediction of protein secondary structure at high accuracy using a combination of many neural networks Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2666: 117-122. DOI: 10.1016/S1093-3263(00)80118-7  0.296
1998 Hansen JE, Lund O, Tolstrup N, Gooley AA, Williams KL, Brunak S. NetOglyc: Prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility Glycoconjugate Journal. 15: 115-130. PMID 9557871 DOI: 10.1023/A:1006960004440  0.295
2017 Geertz-Hansen HM, Kiemer L, Nielsen M, Stanchev K, Blom N, Brunak S, Petersen TN. Protein features as determinants of wild-type glycoside hydrolase thermostability. Proteins. PMID 28734034 DOI: 10.1002/Prot.25357  0.295
2002 Keşmir C, Nussbaum AK, Schild H, Detours V, Brunak S. Prediction of proteasome cleavage motifs by neural networks Protein Engineering. 15: 287-296. PMID 11983929 DOI: 10.1093/Protein/15.4.287  0.295
2009 Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, et al. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Molecular Oncology. 3: 9-17. PMID 19383362 DOI: 10.1016/J.Molonc.2008.11.003  0.295
1998 Pedersen AG, Baldi P, Chauvin Y, Brunak S. DNA structure in human RNA polymerase II promoters Journal of Molecular Biology. 281: 663-673. PMID 9710538 DOI: 10.1006/Jmbi.1998.1972  0.294
2008 Sylvester-Hvid C, Nielsen M, Lamberth K, Røder G, Justesen S, Lundegaard C, Worning P, Thomadsen H, Lund O, Brunak S, Buus S. SARS CTL Vaccine Candidates — HLA Supertype, Genome‐Wide Scanning and Biochemical Validation Scandinavian Journal of Immunology. 59: 632-632. DOI: 10.1111/J.0300-9475.2004.01423Bd.X  0.293
2003 la Cour T, Gupta R, Rapacki K, Skriver K, Poulsen FM, Brunak S. NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Research. 31: 393-6. PMID 12520031 DOI: 10.1093/Nar/Gkg101  0.293
2019 Almagro Armenteros JJ, Tsirigos KD, Sønderby CK, Petersen TN, Winther O, Brunak S, von Heijne G, Nielsen H. SignalP 5.0 improves signal peptide predictions using deep neural networks. Nature Biotechnology. PMID 30778233 DOI: 10.1038/S41587-019-0036-Z  0.292
1997 Reese MG, Lund O, Bohr J, Bohr H, Hansen JE, Brunak S. Distance distributions in proteins: a six-parameter representation. Protein Engineering. 9: 733-40. PMID 8888138 DOI: 10.1093/Protein/9.9.733  0.292
2004 Sylvester-Hvid C, Nielsen M, Lamberth K, Røder G, Justesen S, Lundegaard C, Worning P, Thomadsen H, Lund O, Brunak S, Buus S. SARS CTL vaccine candidates; HLA supertype-, genome-wide scanning and biochemical validation Tissue Antigens. 63: 395-400. PMID 15104671 DOI: 10.1111/J.0001-2815.2004.00221.X  0.291
2015 WesoÅ‚owska-Andersen A, Borst L, Dalgaard MD, Yadav R, Rasmussen KK, Wehner PS, Rasmussen M, Ørntoft TF, Nordentoft I, Koehler R, Bartram CR, Schrappe M, Sicheritz-Ponten T, Gautier L, Marquart H, ... ... Brunak S, et al. Genomic profiling of thousands of candidate polymorphisms predicts risk of relapse in 778 Danish and German childhood acute lymphoblastic leukemia patients. Leukemia. 29: 297-303. PMID 24990611 DOI: 10.1038/Leu.2014.205  0.291
2016 Ellinghaus D, Jostins L, Spain SL, Cortes A, Bethune J, Han B, Park YR, Raychaudhuri S, Pouget JG, Hübenthal M, Folseraas T, Wang Y, Esko T, Metspalu A, Westra HJ, ... ... Brunak S, et al. Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. Nature Genetics. PMID 26974007 DOI: 10.1038/Ng.3528  0.291
2002 Spicker JS, Wikman F, Lu ML, Cordon-Cardo C, Workman C, Ørntoft TF, Brunak S, Knudsen S. Neural network predicts sequence of TP53 gene based on DNA chip Bioinformatics. 18: 1133-1134. PMID 12176837 DOI: 10.1093/Bioinformatics/18.8.1133  0.291
1997 Tolstrup N, Rouzé P, Brunak S. A branch point consensus from Arabidopsis found by non-circular analysis allows for better prediction of acceptor sites Nucleic Acids Research. 25: 3159-3163. PMID 9224618 DOI: 10.1093/Nar/25.15.3159  0.291
2002 Peleg O, Brunak S, Trifonov EN, Nevo E, Bolshoy A. RNA secondary structure and sequence conservation in C1 region of human immunodeficiency virus type 1 env gene Aids Research and Human Retroviruses. 18: 867-878. PMID 12201910 DOI: 10.1089/08892220260190353  0.29
2014 Krysiak-Baltyn K, Nordahl Petersen T, Audouze K, Jørgensen N, Angquist L, Brunak S. Compass: a hybrid method for clinical and biobank data mining. Journal of Biomedical Informatics. 47: 160-70. PMID 24513869 DOI: 10.1016/J.Jbi.2013.10.007  0.29
2011 Rasmussen M, Guo X, Wang Y, Lohmueller KE, Rasmussen S, Albrechtsen A, Skotte L, Lindgreen S, Metspalu M, Jombart T, Kivisild T, Zhai W, Eriksson A, Manica A, Orlando L, ... ... Brunak S, et al. An Aboriginal Australian genome reveals separate human dispersals into Asia. Science (New York, N.Y.). 334: 94-8. PMID 21940856 DOI: 10.1126/Science.1211177  0.289
1992 Lukashin AV, Engelbrecht J, Brunak S. Multiple alignment using simulated annealing: branch point definition in human mRNA splicing. Nucleic Acids Research. 20: 2511-6. PMID 1598209 DOI: 10.1093/Nar/20.10.2511  0.289
2004 Nielsen M, Lundegaard C, Worning P, Sylvester Hvid C, Lamberth K, Buus S, Brunak S, Lund O. Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach Bioinformatics. 20: 1388-1397. PMID 14962912 DOI: 10.1093/Bioinformatics/Bth100  0.288
2005 Jónsdóttir SO, Jørgensen FS, Brunak S. Prediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates. Bioinformatics (Oxford, England). 21: 2145-60. PMID 15713739 DOI: 10.1093/Bioinformatics/Bti314  0.288
2019 Hansen TF, Banasik K, Erikstrup C, Pedersen OB, Westergaard D, Chmura PJ, Nielsen K, Thørner L, Hjalgrim H, Paarup H, Larsen MAH, Petersen M, Jennum P, Andersen S, Nyegaard M, ... ... Brunak S, et al. DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors. Bmj Open. 9: e028401. PMID 31182452 DOI: 10.1136/Bmjopen-2018-028401  0.288
2015 Ison J, Rapacki K, Ménager H, Kalaš M, Rydza E, Chmura P, Anthon C, Beard N, Berka K, Bolser D, Booth T, Bretaudeau A, Brezovsky J, Casadio R, Cesareni G, ... ... Brunak S, et al. Tools and data services registry: a community effort to document bioinformatics resources. Nucleic Acids Research. PMID 26538599 DOI: 10.1093/Nar/Gkv1116  0.287
2018 Aguayo-Orozco A, Bois FY, Brunak S, Taboureau O. Analysis of Time-Series Gene Expression Data to Explore Mechanisms of Chemical-Induced Hepatic Steatosis Toxicity. Frontiers in Genetics. 9: 396. PMID 30279702 DOI: 10.3389/Fgene.2018.00396  0.286
2009 Bohr H, Bohr J, Brunak S, Cotterill RM, Fredholm H, Lautrup B, Petersen SB. A novel approach to prediction of the 3-dimensional structures of protein backbones by neural networks. Febs Letters. 261: 43-6. PMID 19928342 DOI: 10.1016/0014-5793(90)80632-S  0.285
2007 Lundegaard C, Lund O, Kesmir C, Brunak S, Nielsen M. Modeling the adaptive immune system: predictions and simulations. Bioinformatics (Oxford, England). 23: 3265-75. PMID 18045832 DOI: 10.1093/Bioinformatics/Btm471  0.285
2018 Zepeda Mendoza ML, Roggenbuck M, Manzano Vargas K, Hansen LH, Brunak S, Gilbert MTP, Sicheritz-Pontén T. Protective role of the vulture facial skin and gut microbiomes aid adaptation to scavenging. Acta Veterinaria Scandinavica. 60: 61. PMID 30309375 DOI: 10.1186/S13028-018-0415-3  0.285
2001 Andersen CA, Bohr H, Brunak S. Protein secondary structure: category assignment and predictability. Febs Letters. 507: 6-10. PMID 11682049 DOI: 10.1016/S0014-5793(01)02910-6  0.285
2002 Brunak S, Danchin A, Hattori M, Nakamura H, Shinozaki K, Matise T, Preuss D. Nucleotide sequence database policies [1] Science. 298: 1333. PMID 12436968 DOI: 10.1126/Science.298.5597.1333B  0.284
2005 Bendtsen JD, Nielsen H, Widdick D, Palmer T, Brunak S. Prediction of twin-arginine signal peptides. Bmc Bioinformatics. 6: 167. PMID 15992409 DOI: 10.1186/1471-2105-6-167  0.284
2015 Rasmussen S, Allentoft ME, Nielsen K, Orlando L, Sikora M, Sjögren KG, Pedersen AG, Schubert M, Van Dam A, Kapel CM, Nielsen HB, Brunak S, Avetisyan P, Epimakhov A, Khalyapin MV, et al. Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago. Cell. 163: 571-82. PMID 26496604 DOI: 10.1016/J.Cell.2015.10.009  0.283
2003 Buus S, Lauemøller SL, Worning P, Kesmir C, Frimurer T, Corbet S, Fomsgaard A, Hilden J, Holm A, Brunak S. Sensitive quantitative predictions of peptide-MHC binding by a 'Query by Committee' artificial neural network approach Tissue Antigens. 62: 378-384. PMID 14617044 DOI: 10.1034/J.1399-0039.2003.00112.X  0.283
2016 Pedersen HK, Gudmundsdottir V, Pedersen MK, Brorsson C, Brunak S, Gupta R. Ranking factors involved in diabetes remission after bariatric surgery using machine-learning integrating clinical and genomic biomarkers. Npj Genomic Medicine. 1: 16035. PMID 29263820 DOI: 10.1038/Npjgenmed.2016.35  0.283
2001 Jarmer H, Larsen TS, Krogh A, Saxild HH, Brunak S, Knudsen S. Sigma A recognition sites in the Bacillus subtilis genome. Microbiology (Reading, England). 147: 2417-24. PMID 11535782 DOI: 10.1099/00221287-147-9-2417  0.283
2008 Miller ML, Hanke S, Hinsby AM, Friis C, Brunak S, Mann M, Blom N. Motif decomposition of the phosphotyrosine proteome reveals a new N-terminal binding motif for SHIP2. Molecular & Cellular Proteomics : McP. 7: 181-92. PMID 17938406 DOI: 10.1074/Mcp.M700241-Mcp200  0.283
1999 Gupta R, Birch H, Rapacki K, Brunak S, Hansen JE. O-GLYCBASE version 4.0: A revised database of O-glycosylated proteins Nucleic Acids Research. 27: 370-372. PMID 9847232 DOI: 10.1093/Nar/27.1.370  0.283
2014 Raghavan M, Skoglund P, Graf KE, Metspalu M, Albrechtsen A, Moltke I, Rasmussen S, Stafford TW, Orlando L, Metspalu E, Karmin M, Tambets K, Rootsi S, Mägi R, Campos PF, ... ... Brunak S, et al. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature. 505: 87-91. PMID 24256729 DOI: 10.1038/Nature12736  0.282
2008 Lage K, Hansen NT, Karlberg EO, Eklund AC, Roque FS, Donahoe PK, Szallasi Z, Jensen TS, Brunak S. A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes. Proceedings of the National Academy of Sciences of the United States of America. 105: 20870-5. PMID 19104045 DOI: 10.1073/Pnas.0810772105  0.282
2017 Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G. Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. Molecular Cancer Therapeutics. 16: 88-101. PMID 28062706 DOI: 10.1158/1535-7163.Mct-16-0235  0.282
2019 Njølstad PR, Andreassen OA, Brunak S, Børglum AD, Dillner J, Esko T, Franks PW, Freimer N, Groop L, Heimer H, Hougaard DM, Hovig E, Hveem K, Jalanko A, Kaprio J, et al. Roadmap for a precision-medicine initiative in the Nordic region. Nature Genetics. PMID 30988515 DOI: 10.1038/S41588-019-0391-1  0.281
2020 Brunak S, Bjerre Collin C, Eva Ó Cathaoir K, Golebiewski M, Kirschner M, Kockum I, Moser H, Waltemath D. Towards standardization guidelines for in silico approaches in personalized medicine. Journal of Integrative Bioinformatics. 17. PMID 32827396 DOI: 10.1515/Jib-2020-0006  0.281
2015 Allentoft ME, Sikora M, Sjögren KG, Rasmussen S, Rasmussen M, Stenderup J, Damgaard PB, Schroeder H, Ahlström T, Vinner L, Malaspinas AS, Margaryan A, Higham T, Chivall D, Lynnerup N, ... ... Brunak S, et al. Population genomics of Bronze Age Eurasia. Nature. 522: 167-72. PMID 26062507 DOI: 10.1038/Nature14507  0.281
2012 Stranzl T, Larsen MV, Lund O, Nielsen M, Brunak S. The cancer exome generated by alternative mRNA splicing dilutes predicted HLA class I epitope density. Plos One. 7: e38670. PMID 23049726 DOI: 10.1371/Journal.Pone.0038670  0.28
2002 Ussery D, Soumpasis DM, Brunak S, Staerfeldt HH, Worning P, Krogh A. Bias of purine stretches in sequenced chromosomes. Computers & Chemistry. 26: 531-41. PMID 12144181 DOI: 10.1016/S0097-8485(02)00013-X  0.28
2014 Kouskoumvekaki I, Shublaq N, Brunak S. Facilitating the use of large-scale biological data and tools in the era of translational bioinformatics. Briefings in Bioinformatics. 15: 942-52. PMID 23908249 DOI: 10.1093/Bib/Bbt055  0.279
2012 Taboureau O, Hersey A, Audouze KML, Gautier L, Jacobsen UP, Akhtar R, Atkinson F, Overington JP, Brunak S. Toxicogenomics Investigation Under the eTOX Project Journal of Pharmacogenomics and Pharmacoproteomics. 1-5. DOI: 10.4172/2153-0645.S7-001  0.278
2006 Regenberg B, Grotkjaer T, Winther O, Fausbøll A, Akesson M, Bro C, Hansen LK, Brunak S, Nielsen J. Growth-rate regulated genes have profound impact on interpretation of transcriptome profiling in Saccharomyces cerevisiae. Genome Biology. 7: R107. PMID 17105650 DOI: 10.1186/Gb-2006-7-11-R107  0.277
2013 Tinti M, Kiemer L, Costa S, Miller ML, Sacco F, Olsen JV, Carducci M, Paoluzi S, Langone F, Workman CT, Blom N, Machida K, Thompson CM, Schutkowski M, Brunak S, et al. The SH2 domain interaction landscape. Cell Reports. 3: 1293-305. PMID 23545499 DOI: 10.1016/J.Celrep.2013.03.001  0.277
2002 Yusim K, Kesmir C, Gaschen B, Addo MM, Altfeld M, Brunak S, Chigaev A, Detours V, Korber BT. Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation Journal of Virology. 76: 8757-8768. PMID 12163596 DOI: 10.1128/Jvi.76.17.8757-8768.2002  0.277
2000 Baldi P, Brunak S, Chauvin Y, Andersen CA, Nielsen H. Assessing the accuracy of prediction algorithms for classification: an overview. Bioinformatics (Oxford, England). 16: 412-24. PMID 10871264 DOI: 10.1093/Bioinformatics/16.5.412  0.277
2019 Saunders G, Baudis M, Becker R, Beltran S, Béroud C, Birney E, Brooksbank C, Brunak S, Van den Bulcke M, Drysdale R, Capella-Gutierrez S, Flicek P, Florindi F, Goodhand P, Gut I, et al. Author Correction: Leveraging European infrastructures to access 1 million human genomes by 2022. Nature Reviews. Genetics. PMID 31520075 DOI: 10.1038/S41576-019-0178-3  0.276
2014 Lohmueller KE, Sparsø T, Li Q, Andersson E, Korneliussen T, Albrechtsen A, Banasik K, Grarup N, Hallgrimsdottir I, Kiil K, Kilpeläinen TO, Krarup NT, Pers TH, Sanchez G, Hu Y, ... ... Brunak S, et al. Erratum: Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes (The American Journal of Human Genetics (2013) 93 (1072-1086)) American Journal of Human Genetics. 94. DOI: 10.1016/J.Ajhg.2014.02.002  0.276
2008 Thorsen K, Sørensen KD, Brems-Eskildsen AS, Modin C, Gaustadnes M, Hein AM, Kruhøffer M, Laurberg S, Borre M, Wang K, Brunak S, Krainer AR, Tørring N, Dyrskjøt L, Andersen CL, et al. Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis. Molecular & Cellular Proteomics : McP. 7: 1214-24. PMID 18353764 DOI: 10.1074/Mcp.M700590-Mcp200  0.275
1996 Hansen JE, Lund O, Nielsen JO, Hansen JE, Brunak S. O-GLYCBASE: a revised database of O-glycosylated proteins. Nucleic Acids Research. 24: 248-52. PMID 8594592 DOI: 10.1093/Nar/24.1.248  0.275
2016 Beck MK, Jensen AB, Nielsen AB, Perner A, Moseley PL, Brunak S. Diagnosis trajectories of prior multi-morbidity predict sepsis mortality. Scientific Reports. 6: 36624. PMID 27812043 DOI: 10.1038/Srep36624  0.275
2003 Christensen JK, Lamberth K, Nielsen M, Lundegaard C, Worning P, Lauemøller SL, Buus S, Brunak S, Lund O. Selecting Informative Data for Developing Peptide-MHC Binding Predictors Using a Query by Committee Approach Neural Computation. 15: 2931-2942. PMID 14629874 DOI: 10.1162/089976603322518803  0.274
2020 Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, ... ... Brunak S, et al. Pathway and network analysis of more than 2500 whole cancer genomes. Nature Communications. 11: 729. PMID 32024854 DOI: 10.1038/S41467-020-14367-0  0.274
2001 Lauemøller SL, Holm A, Hilden J, Brunak S, Holst Nissen M, Stryhn A, Stergaard Pedersen L, Buus S. Quantitative predictions of peptide binding to MHC class I molecules using specificity matrices and anchor-stratified calibrations Tissue Antigens. 57: 405-414. PMID 11556965 DOI: 10.1034/J.1399-0039.2001.057005405.X  0.274
1991 Brunak S, Engelbrecht J, Knudsen S. Prediction of human mRNA donor and acceptor sites from the DNA sequence. Journal of Molecular Biology. 220: 49-65. PMID 2067018 DOI: 10.1016/0022-2836(91)90380-O  0.274
2015 Kjartansdóttir KR, Friis-Nielsen J, Asplund M, Mollerup S, Mourier T, Jensen RH, Hansen TA, Rey-Iglesia A, Richter SR, Alquezar-Planas DE, Olsen PV, Vinner L, Fridholm H, Sicheritz-Pontén T, Nielsen LP, ... Brunak S, et al. Traces of ATCV-1 associated with laboratory component contamination. Proceedings of the National Academy of Sciences of the United States of America. 112: E925-6. PMID 25654983 DOI: 10.1073/Pnas.1423756112  0.274
1990 Brunak S, Engelbrecht J, Knudsen S. Cleaning up gene databases. Nature. 343: 123. PMID 2296305 DOI: 10.1038/343123A0  0.274
1997 Gorodkin J, Heyer LJ, Brunak S, Stormo GD. Displaying the information contents of structural RNA alignments: The structure logos Computer Applications in the Biosciences. 13: 583-586. PMID 9475985 DOI: 10.1093/Bioinformatics/13.6.583  0.271
2018 Matey-Hernandez ML, Brunak S, Izarzugaza JMG. Benchmarking the HLA typing performance of Polysolver and Optitype in 50 Danish parental trios. Bmc Bioinformatics. 19: 239. PMID 29940840 DOI: 10.1186/S12859-018-2239-6  0.271
2016 Mollerup S, Friis-Nielsen J, Vinner L, Hansen TA, Richter SR, Fridholm H, Herrera JA, Lund O, Brunak S, Izarzugaza JM, Mourier T, Nielsen LP, Hansen AJ. Propionibacterium acnes - disease causing agent or common contaminant? Detection in diverse patient samples by next generation sequencing. Journal of Clinical Microbiology. PMID 26818667 DOI: 10.1128/Jcm.02723-15  0.271
1999 Gorodkin J, Stærfeldt HH, Lund O, Brunak S. MatrixPlot: Visualizing sequence constraints Bioinformatics. 15: 769-770. PMID 10498780 DOI: 10.1093/Bioinformatics/15.9.769  0.27
2008 Li Q, Jørgensen FS, Oprea T, Brunak S, Taboureau O. hERG classification model based on a combination of support vector machine method and GRIND descriptors. Molecular Pharmaceutics. 5: 117-27. PMID 18197627 DOI: 10.1021/Mp700124E  0.27
2019 Asplund M, Kjartansdóttir KR, Mollerup S, Vinner L, Fridholm H, Herrera JAR, Friis-Nielsen J, Hansen TA, Jensen RH, Nielsen IB, Richter SR, Rey-Iglesia A, Matey-Hernandez ML, Alquezar-Planas DE, Olsen PVS, ... ... Brunak S, et al. Contaminating viral sequences in high-throughput sequencing viromics: a linkage study of 700 sequencing libraries. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases. PMID 31059795 DOI: 10.1016/J.Cmi.2019.04.028  0.27
2015 Rondas D, Gudmundsdottir V, D'Hertog W, Crèvecoeur I, Waelkens E, Brunak S, Mathieu C, Overbergh L. A proteomic study of the regulatory role for STAT-1 in cytokine-induced beta-cell death. Proteomics. Clinical Applications. PMID 25712914 DOI: 10.1002/Prca.201400124  0.27
2017 Mollerup S, Fridholm H, Vinner L, Kjartansdóttir KR, Friis-Nielsen J, Asplund M, Herrera JA, Steiniche T, Mourier T, Brunak S, Willerslev E, Izarzugaza JM, Hansen AJ, Nielsen LP. Cutavirus in Cutaneous Malignant Melanoma. Emerging Infectious Diseases. 23: 363-365. PMID 28098541 DOI: 10.3201/Eid2302.161564  0.269
2001 Baisnée PF, Baldi P, Brunak S, Pedersen AG. Flexibility of the genetic code with respect to DNA structure. Bioinformatics (Oxford, England). 17: 237-48. PMID 11294789 DOI: 10.1093/Bioinformatics/17.3.237  0.269
2013 Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, et al. Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology. The Embo Journal. 32: 1478-88. PMID 23584533 DOI: 10.1038/Emboj.2013.79  0.268
2006 Hansen NT, Kouskoumvekaki I, Jørgensen FS, Brunak S, Jónsdóttir SO. Prediction of pH-dependent aqueous solubility of druglike molecules. Journal of Chemical Information and Modeling. 46: 2601-9. PMID 17125200 DOI: 10.1021/Ci600292Q  0.268
1997 Bohr J, Bohr H, Brunak S. Protein folding and wring resonances Biophysical Chemistry. 63: 97-105. DOI: 10.1016/S0301-4622(96)02249-1  0.268
2010 Kristensen DM, Nielsen JE, Kalisz M, Dalgaard MD, Audouze K, Larsen ME, Jacobsen GK, Horn T, Brunak S, Skakkebaek NE, Leffers H. OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheres. Molecular Human Reproduction. 16: 835-45. PMID 20123703 DOI: 10.1093/Molehr/Gaq008  0.267
2006 Bourne PE, Brunak S. ISMB 2006 Bioinformatics. 22: e1-e2. PMID 16873486 DOI: 10.1093/Bioinformatics/Btl373  0.266
1997 Lund O, Hansen J, Brunak S, Bohr J. Relationship between protein structure and geometrical constraints. Protein Science : a Publication of the Protein Society. 5: 2217-25. PMID 8931140 DOI: 10.1002/Pro.5560051108  0.266
2013 Belling KC, Tanaka M, Dalgaard MD, Nielsen JE, Nielsen HB, Brunak S, Almstrup K, Leffers H. Transcriptome profiling of mice testes following low dose irradiation. Reproductive Biology and Endocrinology : Rb&E. 11: 50. PMID 23714422 DOI: 10.1186/1477-7827-11-50  0.265
2016 Malaspinas AS, Westaway MC, Muller C, Sousa VC, Lao O, Alves I, Bergström A, Athanasiadis G, Cheng JY, Crawford JE, Heupink TH, Macholdt E, Peischl S, Rasmussen S, Schiffels S, ... ... Brunak S, et al. A genomic history of Aboriginal Australia. Nature. PMID 27654914 DOI: 10.1038/Nature18299  0.265
1997 Bohr H, Brunak S, Bohr J. Coherent topological phenomena in protein folding Folding and Design. 2: S15-S18. PMID 9218961 DOI: 10.1016/S1359-0278(97)00058-8  0.265
1994 Tolstrup N, Toftgård J, Engelbrecht J, Brunak S. Neural network model of the genetic code is strongly correlated to the GES scale of amino acid transfer free energies. Journal of Molecular Biology. 243: 816-20. PMID 7966302 DOI: 10.1006/Jmbi.1994.1683  0.265
2014 Hauptmann AL, Stibal M, Bælum J, Sicheritz-Pontén T, Brunak S, Bowman JS, Hansen LH, Jacobsen CS, Blom N. Bacterial diversity in snow on North Pole ice floes. Extremophiles : Life Under Extreme Conditions. 18: 945-51. PMID 24951969 DOI: 10.1007/S00792-014-0660-Y  0.265
2020 Niss K, Jakobsson ME, Westergaard D, Belling KG, Olsen JV, Brunak S. Effects of active farnesoid X receptor on GLUTag enteroendocrine L cells. Molecular and Cellular Endocrinology. 110923. PMID 32702472 DOI: 10.1016/J.Mce.2020.110923  0.265
2010 Halling-Brown M, Pappalardo F, Rapin N, Zhang P, Alemani D, Emerson A, Castiglione F, Duroux P, Pennisi M, Miotto O, Churchill D, Rossi E, Moss DS, Sansom CE, Bernaschi M, ... ... Brunak S, et al. ImmunoGrid: towards agent-based simulations of the human immune system at a natural scale. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 368: 2799-815. PMID 20439274 DOI: 10.1098/Rsta.2010.0067  0.265
1996 Bohr J, Bohr H, Brunak S. The Formation of Protein Structure Europhysics News. 27: 50-54. DOI: 10.1051/Epn/19962702050  0.265
2011 Kristensen DM, Skalkam ML, Audouze K, Lesné L, Desdoits-Lethimonier C, Frederiksen H, Brunak S, Skakkebæk NE, Jégou B, Hansen JB, Junker S, Leffers H. Many putative endocrine disruptors inhibit prostaglandin synthesis. Environmental Health Perspectives. 119: 534-41. PMID 21081300 DOI: 10.1289/Ehp.1002635  0.264
2014 Koivula RW, Heggie A, Barnett A, Cederberg H, Hansen TH, Koopman AD, RidderstrÃ¥le M, Rutters F, Vestergaard H, Gupta R, HerrgÃ¥rd S, Heymans MW, Perry MH, Rauh S, Siloaho M, ... ... Brunak S, et al. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. 57: 1132-42. PMID 24695864 DOI: 10.1007/S00125-014-3216-X  0.263
2004 Bovin LF, Rieneck K, Workman C, Nielsen H, Sørensen SF, Skjødt H, Florescu A, Brunak S, Bendtzen K. Blood cell gene expression profiling in rheumatoid arthritis. Discriminative genes and effect of rheumatoid factor. Immunology Letters. 93: 217-26. PMID 15158620 DOI: 10.1016/J.Imlet.2004.03.018  0.263
2019 Briand E, Thomsen R, Linnet K, Rasmussen HB, Brunak S, Taboureau O. Combined Ensemble Docking and Machine Learning in Identification of Therapeutic Agents with Potential Inhibitory Effect on Human CES1. Molecules (Basel, Switzerland). 24. PMID 31362390 DOI: 10.3390/Molecules24152747  0.262
2019 Jia G, Li Y, Zhang H, Chattopadhyay I, Boeck Jensen A, Blair DR, Davis L, Robinson PN, Dahlén T, Brunak S, Benson M, Edgren G, Cox NJ, Gao X, Rzhetsky A. Estimating heritability and genetic correlations from large health datasets in the absence of genetic data. Nature Communications. 10: 5508. PMID 31796735 DOI: 10.1038/S41467-019-13455-0  0.261
2019 Kirk IK, Simon C, Banasik K, Holm PC, Haue AD, Jensen PB, Juhl Jensen L, Rodríguez CL, Pedersen MK, Eriksson R, Andersen HU, Almdal T, Bork-Jensen J, Grarup N, Borch-Johnsen K, ... ... Brunak S, et al. Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining. Elife. 8. PMID 31818369 DOI: 10.7554/Elife.44941  0.26
2012 Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Audouze K, Brunak S, Main KM. Association between chemical pattern in breast milk and congenital cryptorchidism: modelling of complex human exposures. International Journal of Andrology. 35: 294-302. PMID 22519522 DOI: 10.1111/J.1365-2605.2012.01268.X  0.26
2007 Thorn M, Wang M, Kløverpris H, Schmidt EG, Fomsgaard A, Wenandy L, Berntsen A, Brunak S, Buus S, Claesson MH. Identification of a new hTERT-derived HLA-A*0201 restricted, naturally processed CTL epitope. Cancer Immunology, Immunotherapy : Cii. 56: 1755-63. PMID 17464507 DOI: 10.1007/S00262-007-0319-Y  0.259
2015 Rasmussen HB, Bjerre D, Linnet K, Jürgens G, Dalhoff K, Stefansson H, Hankemeier T, Kaddurah-Daouk R, Taboureau O, Brunak S, Houmann T, Jeppesen P, Pagsberg AK, Plessen K, Dyrborg J, et al. Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics. Pharmacogenomics. 16: 649-65. PMID 25896426 DOI: 10.2217/Pgs.15.7  0.259
2017 Lottrup G, Belling K, Leffers H, Nielsen JE, Dalgaard MD, Juul A, Skakkebæk NE, Brunak S, Rajpert-De Meyts E. Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents. Molecular Human Reproduction. 1-16. PMID 28333300 DOI: 10.1093/Molehr/Gax012  0.259
2012 Jørgensen JR, Fransson A, Fjord-Larsen L, Thompson LH, Houchins JP, Andrade N, Torp M, Kalkkinen N, Andersson E, Lindvall O, Ulfendahl M, Brunak S, Johansen TE, Wahlberg LU. Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. Experimental Neurology. 233: 172-81. PMID 21985865 DOI: 10.1016/J.Expneurol.2011.09.027  0.258
2002 Andersen CA, Palmer AG, Brunak S, Rost B. Continuum secondary structure captures protein flexibility. Structure (London, England : 1993). 10: 175-84. PMID 11839303 DOI: 10.1016/S0969-2126(02)00700-1  0.258
2016 Folkersen L, Brynedal B, Diaz-Gallo LM, Ramsköld D, Shchetynsky K, Westerlind H, Sundström Y, Schepis D, Hensvold A, Vivar N, Eloranta ML, Rönnblom L, Brunak S, Malmström V, Catrina A, et al. Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study. Molecular Medicine (Cambridge, Mass.). 22. PMID 27532898 DOI: 10.2119/Molmed.2016.00078  0.258
2013 Spisák S, Solymosi N, Ittzés P, Bodor A, Kondor D, Vattay G, Barták BK, Sipos F, Galamb O, Tulassay Z, Szállási Z, Rasmussen S, Sicheritz-Ponten T, Brunak S, Molnár B, et al. Complete genes may pass from food to human blood. Plos One. 8: e69805. PMID 23936105 DOI: 10.1371/Journal.Pone.0069805  0.257
2018 Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, De Masi F, Munkbøl CH, Styrishave B, Antignac JP, Le Bizec B, Platel C, Hay-Schmidt A, Jensen TK, Lesné L, Mazaud-Guittot S, Kristiansen K, ... Brunak S, et al. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311296 DOI: 10.1073/Pnas.1715035115  0.256
2003 Corbet S, Nielsen HV, Vinner L, Lauemoller S, Therrien D, Tang S, Kronborg G, Mathiesen L, Chaplin P, Brunak S, Buus S, Fomsgaard A. Optimization and immune recognition of multiple novel conserved HLA-A2, human immunodeficiency virus type 1-specific CTL epitopes Journal of General Virology. 84: 2409-2421. PMID 12917462 DOI: 10.1099/Vir.0.19152-0  0.256
2020 Blair JPM, Bay-Jensen AC, Tang MH, Frederiksen P, Bager C, Karsdal M, Brunak S. Identification of heterogenous treatment response trajectories to anti-IL6 receptor treatment in rheumatoid arthritis. Scientific Reports. 10: 13975. PMID 32811969 DOI: 10.1038/S41598-020-70942-X  0.256
2009 Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L, Harrison NJ, Schwager C, Abdollahi A, Huber PE, Brunak S, Gjerdrum LM, Moore HD, Andrews PW, Skakkebaek NE, et al. Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Research. 69: 5241-50. PMID 19491264 DOI: 10.1158/0008-5472.Can-08-4554  0.255
2011 Schjoldager KT, Vester-Christensen MB, Goth CK, Petersen TN, Brunak S, Bennett EP, Levery SB, Clausen H. A systematic study of site-specific GalNAc-type O-glycosylation modulating proprotein convertase processing. The Journal of Biological Chemistry. 286: 40122-32. PMID 21937429 DOI: 10.1074/Jbc.M111.287912  0.255
2000 Frimurer TM, Bywater R, Nærum L, Lauritsen LN, Brunak S. Improving the Odds in Discriminating "Drug-like" from "Non Drug-like" Compounds Journal of Chemical Information and Computer Sciences. 40: 1315-1324. PMID 11128089 DOI: 10.1021/Ci0003810  0.255
2016 Belling K, Russo F, Jensen AB, Dalgaard MD, Westergaard D, Skakkebæk NE, Juul A, Brunak S. Klinefelter syndrome comorbidities induced by increased X chromosome gene dosages and altered protein interactome activity F1000research. 5. DOI: 10.7490/F1000Research.1113023.1  0.254
2020 Sørup FKH, Brunak S, Eriksson R. Association between antipsychotic drug dose and length of clinical notes: a proxy of disease severity? Bmc Medical Research Methodology. 20: 107. PMID 32381026 DOI: 10.1186/S12874-020-00993-1  0.254
2018 Hu JX, Helleberg M, Jensen AB, Brunak S, Lundgren J. A large-cohort, longitudinal study determines pre-cancer disease routes across different cancer types. Cancer Research. PMID 30591553 DOI: 10.1158/0008-5472.Can-18-1677  0.254
1991 Petersen SB, Bohr H, Bohr J, Brunak S, Cotterill RM, Fredholm H, Lautrup B. Training neural networks to analyse biological sequences. Trends in Biotechnology. 8: 304-8. PMID 1366766 DOI: 10.1016/0167-7799(90)90206-D  0.254
2004 Lund O, Nielsen M, Kesmir C, Petersen AG, Lundegaard C, Worning P, Sylvester-Hvid C, Lamberth K, Røder G, Justesen S, Buus S, Brunak S. Definition of supertypes for HLA molecules using clustering of specificity matrices Immunogenetics. 55: 797-810. PMID 14963618 DOI: 10.1007/S00251-004-0647-4  0.253
2014 Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, Brunak S, Taboureau O. Identification of odorant-receptor interactions by global mapping of the human odorome. Plos One. 9: e93037. PMID 24695519 DOI: 10.1371/Journal.Pone.0093037  0.253
2001 Gorodkin J, Søgaard B, Bay H, Doll H, Kølster P, Brunak S. Recognition of environmental and genetic effects on barley phenolic fingerprints by neural networks Computers and Chemistry. 25: 301-307. PMID 11339412 DOI: 10.1016/S0097-8485(00)00103-0  0.253
2018 Wendland K, Niss K, Kotarsky K, Wu NYH, White AJ, Jendholm J, Rivollier A, Izarzugaza JMG, Brunak S, Holländer GA, Anderson G, Sitnik KM, Agace WW. Retinoic Acid Signaling in Thymic Epithelial Cells Regulates Thymopoiesis. Journal of Immunology (Baltimore, Md. : 1950). PMID 29848752 DOI: 10.4049/Jimmunol.1800418  0.252
2018 Teare HJA, de Masi F, Banasik K, Barnett A, Herrgard S, Jablonka B, Postma JWM, McDonald TJ, Forgie I, Chmura PJ, Rydzka EK, Gupta R, Brunak S, Pearson E, Kaye J. The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project. Life Sciences, Society and Policy. 14: 20. PMID 30182269 DOI: 10.1186/S40504-018-0083-0  0.251
1996 Hansen JE, Lund O, Nielsen JO, Brunak S, Hansen JE. Prediction of the secondary structure of HIV-1 gp120. Proteins. 25: 1-11. PMID 8727315 DOI: 10.1002/(Sici)1097-0134(199605)25:1<1::Aid-Prot1>3.0.Co;2-N  0.251
2020 Fenton TM, Jørgensen PB, Niss K, Rubin SJS, Mörbe UM, Riis LB, Da Silva C, Plumb A, Vandamme J, Jakobsen HL, Brunak S, Habtezion A, Nielsen OH, Johansson-Lindbom B, Agace WW. Immune Profiling of Human Gut-Associated Lymphoid Tissue Identifies a Role for Isolated Lymphoid Follicles in Priming of Region-Specific Immunity. Immunity. PMID 32160523 DOI: 10.1016/J.Immuni.2020.02.001  0.25
2001 Petersen TR, Buus S, Brunak S, Nissen MH, Sherman LA, Claesson MH. Identification and design of p53-derived HLA-A2-binding peptides with increased CTL immunogenicity. Scandinavian Journal of Immunology. 53: 357-64. PMID 11285115 DOI: 10.1046/J.1365-3083.2001.00887.X  0.25
2020 Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, et al. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. PMID 32002573 DOI: 10.1007/S00125-019-05083-6  0.248
2019 Ison J, Ienasescu H, Chmura P, Rydza E, Ménager H, Kalaš M, Schwämmle V, Grüning B, Beard N, Lopez R, Duvaud S, Stockinger H, Persson B, Vařeková RS, Raček T, ... ... Brunak S, et al. The bio.tools registry of software tools and data resources for the life sciences. Genome Biology. 20: 164. PMID 31405382 DOI: 10.1186/S13059-019-1772-6  0.247
2019 Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O. sAOP: Linking chemical stressors to Adverse Outcomes Pathway Networks. Bioinformatics (Oxford, England). PMID 31329252 DOI: 10.1093/Bioinformatics/Btz570  0.246
2017 Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G. Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter. Scientific Reports. 7: 3091. PMID 28596528 DOI: 10.1038/S41598-017-03129-6  0.245
2010 Krysiak-Baltyn K, Toppari J, Skakkebaek NE, Jensen TS, Virtanen HE, Schramm KW, Shen H, Vartiainen T, Kiviranta H, Taboureau O, Brunak S, Main KM. Country-specific chemical signatures of persistent environmental compounds in breast milk. International Journal of Andrology. 33: 270-8. PMID 19780864 DOI: 10.1111/J.1365-2605.2009.00996.X  0.245
2019 Russo F, Hu JX, Romero Herrera JA, Brunak S. Combing the Hairball: Improving Visualization of miRNA-Target Interaction Networks. Methods in Molecular Biology (Clifton, N.J.). 1970: 279-289. PMID 30963498 DOI: 10.1007/978-1-4939-9207-2_15  0.245
2019 Westergaard D, Moseley P, Sørup FKH, Baldi P, Brunak S. Population-wide analysis of differences in disease progression patterns in men and women. Nature Communications. 10: 666. PMID 30737381 DOI: 10.1038/S41467-019-08475-9  0.244
2017 Molnos S, Wahl S, Haid M, Eekhoff EMW, Pool R, Floegel A, Deelen J, Much D, Prehn C, Breier M, Draisma HH, van Leeuwen N, Simonis-Bik AMC, Jonsson A, Willemsen G, ... ... Brunak S, et al. Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study. Diabetologia. PMID 28936587 DOI: 10.1007/S00125-017-4436-7  0.243
2017 Crèvecoeur I, Gudmundsdottir V, Vig S, Marques Câmara Sodré F, D'Hertog W, Fierro AC, Van Lommel L, Gysemans C, Marchal K, Waelkens E, Schuit F, Brunak S, Overbergh L, Mathieu C. Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis. Diabetologia. PMID 28078386 DOI: 10.1007/S00125-016-4191-1  0.242
2016 Ellesøe SG, Jensen AB, Ängquist LH, Hjortdal VE, Larsen LA, Brunak S. How Suitable Are Registry Data for Recurrence Risk Calculations? Validation of Diagnoses on 1,593 Families With Congenital Heart Disease. World Journal For Pediatric & Congenital Heart Surgery. 7: 169-77. PMID 26957399 DOI: 10.1177/2150135115615786  0.239
2015 Jensen AB, Ajslev TA, Brunak S, Sørensen TI. Long-term risk of cardiovascular and cerebrovascular disease after removal of the colonic microbiota by colectomy: a cohort study based on the Danish National Patient Register from 1996 to 2014. Bmj Open. 5: e008702. PMID 26671951 DOI: 10.1136/Bmjopen-2015-008702  0.237
2012 Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C, Sanz F, Brookes AJ. Knowledge engineering for health: a new discipline required to bridge the "ICT gap" between research and healthcare. Human Mutation. 33: 797-802. PMID 22392843 DOI: 10.1002/Humu.22066  0.237
2019 Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, ... ... Brunak S, et al. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium. Diabetologia. PMID 31203377 DOI: 10.1007/S00125-019-4906-1  0.237
2000 Corbet S, Müller-Trutwin MC, Versmisse P, Delarue S, Ayouba A, Lewis J, Brunak S, Martin P, Brun-Vezinet F, Simon F, Barre-Sinoussi F, Mauclere P. env sequences of simian immunodeficiency viruses from chimpanzees in cameroon are strongly related to those of human immunodeficiency virus group N from the same geographic area Journal of Virology. 74: 529-534. PMID 10590144 DOI: 10.1128/Jvi.74.1.529-534.2000  0.236
2020 Izarzugaza JMG, Ellesøe SG, Doganli C, Ehlers NS, Dalgaard MD, Audain E, Dombrowsky G, Banasik K, Sifrim A, Wilsdon A, Thienpont B, Breckpot J, Gewillig M, Brook JD, ... ... Brunak S, et al. Systems genetics analysis identifies calcium-signaling defects as novel cause of congenital heart disease. Genome Medicine. 12: 76. PMID 32859249 DOI: 10.1186/S13073-020-00772-Z  0.236
2020 Atabaki-Pasdar N, Ohlsson M, Viñuela A, Frau F, Pomares-Millan H, Haid M, Jones AG, Thomas EL, Koivula RW, Kurbasic A, Mutie PM, Fitipaldi H, Fernandez J, Dawed AY, Giordano GN, ... ... Brunak S, et al. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts. Plos Medicine. 17: e1003149. PMID 32559194 DOI: 10.1371/Journal.Pmed.1003149  0.235
2018 Jensen AB, Sørensen TI, Pedersen O, Jess T, Brunak S, Allin KH. Increase in clinically recorded type 2 diabetes after colectomy. Elife. 7. PMID 30373718 DOI: 10.7554/Elife.37420  0.234
2013 Cases M, Furlong LI, Albanell J, Altman RB, Bellazzi R, Boyer S, Brand A, Brookes AJ, Brunak S, Clark TW, Gea J, Ghazal P, Graf N, Guigó R, Klein TE, et al. Improving data and knowledge management to better integrate health care and research. Journal of Internal Medicine. 274: 321-8. PMID 23808970 DOI: 10.1111/Joim.12105  0.233
2017 Russo F, Belling K, Jensen AB, Scoyni F, Brunak S, Pellegrini M. MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems. Methods in Molecular Biology (Clifton, N.J.). 1580: 281-295. PMID 28439840 DOI: 10.1007/978-1-4939-6866-4_19  0.233
2020 Varga TV, Ali A, Herrera JAR, Ahonen LL, Mattila IM, Al-Sari NH, Legido-Quigley C, Skouby S, Brunak S, Tornberg ÅB. Lipidomic profiles, lipid trajectories and clinical biomarkers in female elite endurance athletes. Scientific Reports. 10: 2349. PMID 32047202 DOI: 10.1038/S41598-020-59127-8  0.233
2020 Westergaard D, Nielsen AP, Mortensen LH, Nielsen HS, Brunak S. Phenome-Wide Analysis of Short- and Long-Run Disease Incidence Following Recurrent Pregnancy Loss Using Data From a 39-Year Period. Journal of the American Heart Association. 9: e015069. PMID 32299291 DOI: 10.1161/Jaha.119.015069  0.232
2020 Helgadottir A, Thorleifsson G, Alexandersson KF, Tragante V, Thorsteinsdottir M, Eiriksson FF, Gretarsdottir S, Björnsson E, Magnusson O, Sveinbjornsson G, Jonsdottir I, Steinthorsdottir V, Ferkingstad E, Jensson BÖ, Stefansson H, ... ... Brunak S, et al. Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease. European Heart Journal. 41: 2618-2628. PMID 32702746 DOI: 10.1093/Eurheartj/Ehaa531  0.232
2017 Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Cases M, Pastor M, Marc P, Wichard J, Briggs K, Watson DK, Kleinöder T, Yang C, Amberg A, Beaumont M, ... ... Brunak S, et al. Legacy data sharing to improve drug safety assessment: the eTOX project. Nature Reviews. Drug Discovery. PMID 29026211 DOI: 10.1038/Nrd.2017.177  0.231
2019 Kirk IK, Simon C, Banasik K, Holm PC, Haue AD, Jensen PB, Jensen LJ, Rodríguez CL, Pedersen MK, Eriksson R, Andersen HU, Almdal T, Bork-Jensen J, Grarup N, Borch-Johnsen K, ... ... Brunak S, et al. Author response: Linking glycemic dysregulation in diabetes to symptoms, comorbidities, and genetics through EHR data mining Elife. DOI: 10.7554/Elife.44941.Sa2  0.231
2013 Overballe-Petersen S, Harms K, Orlando LA, Mayar JV, Rasmussen S, Dahl TW, Rosing MT, Poole AM, Sicheritz-Ponten T, Brunak S, Inselmann S, de Vries J, Wackernagel W, Pybus OG, Nielsen R, et al. Bacterial natural transformation by highly fragmented and damaged DNA. Proceedings of the National Academy of Sciences of the United States of America. 110: 19860-5. PMID 24248361 DOI: 10.1073/Pnas.1315278110  0.229
2020 Eskildsen NK, Eriksson R, Christensen SB, Aghassipour TS, Bygsø MJ, Brunak S, Hansen SL. Implementation and comparison of two text mining methods with a standard pharmacovigilance method for signal detection of medication errors. Bmc Medical Informatics and Decision Making. 20: 94. PMID 32448248 DOI: 10.1186/S12911-020-1097-0  0.228
1994 Bohr J, Brunak S, Nørretranders T. Viscous Trees and Voronoi-Structure Formation in Expanding Systems Europhysics Letters (Epl). 25: 245-252. DOI: 10.1209/0295-5075/25/4/002  0.225
2020 Terkelsen T, Russo F, Gromov P, Haakensen VD, Brunak S, Gromova I, Krogh A, Papaleo E. Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration. Breast Cancer Research : Bcr. 22: 73. PMID 32605588 DOI: 10.1186/S13058-020-01295-6  0.224
2011 Kristensen DM, Hass U, Lesné L, Lottrup G, Jacobsen PR, Desdoits-Lethimonier C, Boberg J, Petersen JH, Toppari J, Jensen TK, Brunak S, Skakkebaek NE, Nellemann C, Main KM, Jégou B, et al. Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat. Human Reproduction (Oxford, England). 26: 235-44. PMID 21059752 DOI: 10.1093/Humrep/Deq323  0.224
2020 Eriksen R, Perez IG, Posma JM, Haid M, Sharma S, Prehn C, Thomas LE, Koivula RW, Bizzotto R, Prehn C, Mari A, Giordano GN, Pavo I, Schwenk JM, De Masi F, ... ... Brunak S, et al. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study. Ebiomedicine. 58: 102932. PMID 32763829 DOI: 10.1016/J.Ebiom.2020.102932  0.223
2019 Lademann M, Lademann M, Boeck Jensen A, Brunak S. Incorporating symptom data in longitudinal disease trajectories for more detailed patient stratification. International Journal of Medical Informatics. 129: 107-113. PMID 31445244 DOI: 10.1016/J.Ijmedinf.2019.06.003  0.223
2020 Kjærsgaard Andersen R, Jørgensen IF, Reguant R, Jemec GBE, Brunak S. Disease Trajectories for Hidradenitis Suppurativa in the Danish Population. Jama Dermatology. PMID 32432647 DOI: 10.1001/Jamadermatol.2020.1281  0.223
2000 Brunak S. The biologist and the computer Trends in Genetics. 16: 97-98. DOI: 10.1016/S0168-9525(99)01903-4  0.222
2009 Pappalardo F, Halling-Brown MD, Rapin N, Zhang P, Alemani D, Emerson A, Paci P, Duroux P, Pennisi M, Palladini A, Miotto O, Churchill D, Rossi E, Shepherd AJ, Moss DS, ... ... Brunak S, et al. ImmunoGrid, an integrative environment for large-scale simulation of the immune system for vaccine discovery, design and optimization. Briefings in Bioinformatics. 10: 330-40. PMID 19383844 DOI: 10.1093/Bib/Bbp014  0.22
2009 Holmkvist J, Banasik K, Andersen G, Unoki H, Jensen TS, Pisinger C, Borch-Johnsen K, Sandbaek A, Lauritzen T, Brunak S, Maeda S, Hansen T, Pedersen O. The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load. Plos One. 4: e5872. PMID 19516902 DOI: 10.1371/Journal.Pone.0005872  0.218
2018 Kristensen DM, Desdoits-Lethimonier C, Mackey AL, Dalgaard MD, Masi FD, Munkbol CH, Styrishave B, Antignac J, Bizec BL, Platel C, Hay-Schmidt A, Jensen TK, Lesne L, Mazaud-Guittot S, Kristiansen K, ... Brunak S, et al. Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism (vol 115, pg E715, 2018) Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 29666267 DOI: 10.1073/Pnas.1805313115  0.218
2020 Sørup FKH, Eriksson R, Westergaard D, Hallas J, Brunak S, Ejdrup Andersen S. Sex differences in text-mined possible adverse drug events associated with drugs for psychosis. Journal of Psychopharmacology (Oxford, England). 269881120903466. PMID 32048538 DOI: 10.1177/0269881120903466  0.218
2019 Nissen J, Trabjerg B, Pedersen MG, Banasik K, Pedersen OB, Sørensen E, Nielsen KR, Erikstrup C, Petersen MS, Paarup HM, Bruun-Rasmussen P, Westergaard D, Hansen TF, Pedersen CB, Werge T, ... ... Brunak S, et al. Herpes Simplex Virus Type 1 infection is associated with suicidal behavior and first registered psychiatric diagnosis in a healthy population. Psychoneuroendocrinology. 108: 150-154. PMID 31284079 DOI: 10.1016/J.Psyneuen.2019.06.015  0.215
2019 Jiang L, Audouze K, Romero Herrera JA, Ängquist LH, Kjærulff SK, Izarzugaza JMG, Tjønneland A, Halkjær J, Overvad K, Sørensen TIA, Brunak S. Conflicting associations between dietary patterns and changes of anthropometric traits across subgroups of middle-aged women and men. Clinical Nutrition (Edinburgh, Scotland). PMID 30857909 DOI: 10.1016/J.Clnu.2019.02.003  0.215
2019 Jørgensen IF, Russo F, Jensen AB, Westergaard D, Lademann M, Hu JX, Brunak S, Belling K. Comorbidity landscape of the Danish patient population affected by chromosome abnormalities. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 31019277 DOI: 10.1038/S41436-019-0519-9  0.214
2012 Audouze K, Kalhauge C, Taboureau O, Brunak S. Food systems biology network to explore diet-health relationships F1000research. 3. DOI: 10.7490/F1000Research.1092196.1  0.214
2015 Ellesøe SG, Johansen MM, Bjerre JV, Hjortdal VE, Brunak S, Larsen LA. Familial Atrial Septal Defect and Sudden Cardiac Death: Identification of a Novel NKX2-5 Mutation and a Review of the Literature. Congenital Heart Disease. PMID 26679770 DOI: 10.1111/Chd.12317  0.214
2014 Wohlfahrt-Veje C, Audouze K, Brunak S, Antignac JP, le Bizec B, Juul A, Skakkebæk NE, Main KM. Polychlorinated dibenzo-p-dioxins, furans, and biphenyls (PCDDs/PCDFs and PCBs) in breast milk and early childhood growth and IGF1. Reproduction (Cambridge, England). 147: 391-9. PMID 24586095 DOI: 10.1530/Rep-13-0422  0.214
2018 Jensen AB, Sørensen TI, Pedersen O, Jess T, Brunak S, Allin KH. Author response: Increase in clinically recorded type 2 diabetes after colectomy Elife. DOI: 10.7554/Elife.37420.016  0.213
2017 Ellesøe SG, Workman CT, Bouvagnet P, Loffredo CA, McBride KL, Hinton RB, van Engelen K, Gertsen EC, Mulder BJM, Postma AV, Anderson RH, Hjortdal VE, Brunak S, Larsen LA. Familial co-occurrence of congenital heart defects follows distinct patterns. European Heart Journal. PMID 29106500 DOI: 10.1093/Eurheartj/Ehx314  0.212
2011 Petersen TN, Brunak S, von Heijne G, Nielsen H. SignalP 4.0: discriminating signal peptides from transmembrane regions. Nature Methods. 8: 785-6. PMID 21959131 DOI: 10.1038/Nmeth.1701  0.211
2016 Russo F, Rizzo M, Belling K, Brunak S, Folkersen L. The hunt for fatal myocardial infarction biomarkers: predictive circulating microRNAs. Annals of Translational Medicine. 4: S1. PMID 27867969 DOI: 10.21037/Atm.2016.08.21  0.21
2020 Jørgensen IF, Aguayo-Orozco A, Lademann M, Brunak S. Age-stratified longitudinal study of Alzheimer's and vascular dementia patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32342671 DOI: 10.1002/Alz.12091  0.208
2019 Burgdorf KS, Trabjerg BB, Pedersen MG, Nissen J, Banasik K, Pedersen OB, Sørensen E, Nielsen KR, Larsen MH, Erikstrup C, Bruun-Rasmussen P, Westergaard D, Thørner LW, Hjalgrim H, Paarup HM, ... Brunak S, et al. Large-scale study of Toxoplasma and Cytomegalovirus shows an association between infection and serious psychiatric disorders. Brain, Behavior, and Immunity. PMID 30685531 DOI: 10.1016/J.Bbi.2019.01.026  0.207
2016 Russo F, Bella SD, Nigita G, Vannini F, Berti G, Scoyni F, Laganà A, Pulvirenti A, Giugno R, Pellegrini M, Belling K, Brunak S, Ferro A. miRandola 2016: the latest version of the circulating RNA database F1000research. 5. DOI: 10.7490/F1000Research.1111760.1  0.206
2022 Halldorsson BV, Eggertsson HP, Moore KHS, Hauswedell H, Eiriksson O, Ulfarsson MO, Palsson G, Hardarson MT, Oddsson A, Jensson BO, Kristmundsdottir S, Sigurpalsdottir BD, Stefansson OA, Beyter D, Holley G, ... ... Brunak S, et al. The sequences of 150,119 genomes in the UK Biobank. Nature. PMID 35859178 DOI: 10.1038/s41586-022-04965-x  0.203
1997 Bohr H, Brunak S, Bohr J. Molecular Wring Resonances in Chain Molecules Bioelectromagnetics. 18: 187-189. PMID 9084871 DOI: 10.1002/(Sici)1521-186X(1997)18:2<187::Aid-Bem13>3.0.Co;2-O  0.201
2000 Lauemøller SL, Kesmir C, Corbet SL, Fomsgaard A, Holm A, Claesson MH, Brunak S, Buus S. Identifying cytotoxic T cell epitopes from genomic and proteomic information: "The human MHC project" Reviews in Immunogenetics. 2: 477-491. PMID 12361091  0.2
2017 Hay-Schmidt A, Finkielman O, Jensen B, Høgsbro C, Bak Holm J, Johansen KH, Jensen TK, Andrade AM, Swan S, Bornehag CG, Brunak S, Jegou B, Kristiansen K, Kristensen DM. Paracetamol/acetaminophen impairs brain masculinisation. Reproduction (Cambridge, England). PMID 28559473 DOI: 10.1530/Rep-17-0165  0.2
2023 Oddsson A, Sulem P, Sveinbjornsson G, Arnadottir GA, Steinthorsdottir V, Halldorsson GH, Atlason BA, Oskarsson GR, Helgason H, Nielsen HS, Westergaard D, Karjalainen JM, Katrinardottir H, Fridriksdottir R, Jensson BO, ... ... Brunak S, et al. Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality. Nature Communications. 14: 3453. PMID 37301908 DOI: 10.1038/s41467-023-38951-2  0.2
2018 Bundgaard H, Jøns C, Lodder EM, Izarzugaza JMG, Romero Herrera JA, Pehrson S, Tfelt-Hansen J, Ahlberg G, Olesen MS, Holst AG, Wellens H, de Villiers C, Hastings R, Stuart G, Brunak S, et al. A Novel Familial Cardiac Arrhythmia Syndrome with Widespread ST-Segment Depression. The New England Journal of Medicine. 379: 1780-1781. PMID 30380381 DOI: 10.1056/Nejmc1807668  0.195
2020 Thomas CE, Häussler RS, Hong M, Raverdy V, Dale M, Canouil M, Mazzoni G, Viñuela A, Froguel P, Brunak S, Schwenk JM. 1901-P: Individual and Longitudinal Effects of Gastric Bypass Surgery on the Circulating Proteome Diabetes. 69. DOI: 10.2337/Db20-1901-P  0.193
2023 Banasik K, Møller PL, Techlo TR, Holm PC, Walters GB, Ingason A, Rosengren A, Rohde PD, Kogelman LJA, Westergaard D, Siggaard T, Chmura PJ, Chalmer MA, Magnússon ÓÞ, Þórisson GÁ, ... ... Brunak S, et al. DanMAC5: a browser of aggregated sequence variants from 8,671 whole genome sequenced Danish individuals. Bmc Genomic Data. 24: 30. PMID 37244984 DOI: 10.1186/s12863-023-01132-7  0.193
2023 Sigurdsson AI, Louloudis I, Banasik K, Westergaard D, Winther O, Lund O, Ostrowski SR, Erikstrup C, Pedersen OBV, Nyegaard M, Brunak S, Vilhjálmsson BJ, Rasmussen S. Deep integrative models for large-scale human genomics. Nucleic Acids Research. PMID 37224538 DOI: 10.1093/nar/gkad373  0.193
1990 Brunak S, Engelbrecht J, Knudsen S. Neural network detects errors in the assignment of mRNA splice sites. Nucleic Acids Research. 18: 4797-801. PMID 2395643 DOI: 10.1093/NAR/18.16.4797  0.184
2023 Brown AA, Fernandez-Tajes JJ, Hong MG, Brorsson CA, Koivula RW, Davtian D, Dupuis T, Sartori A, Michalettou TD, Forgie IM, Adam J, Allin KH, Caiazzo R, Cederberg H, De Masi F, ... ... Brunak S, et al. Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits. Nature Communications. 14: 5062. PMID 37604891 DOI: 10.1038/s41467-023-40569-3  0.183
2021 Dowsett J, Ferkingstad E, Rasmussen LJH, Thørner LW, Magnússon MK, Sugden K, Thorleifsson G, Frigge M, Burgdorf KS, Ostrowski SR, Sørensen E, Erikstrup C, Pedersen OB, Hansen TF, Banasik K, ... Brunak S, et al. Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor. Communications Biology. 4: 655. PMID 34079037 DOI: 10.1038/s42003-021-02144-8  0.18
2019 Hjaltelin JX, Izarzugaza JMG, Jensen LJ, Russo F, Westergaard D, Brunak S. Identification of hyper-rewired genomic stress non-oncogene addiction genes across 15 cancer types. Npj Systems Biology and Applications. 5: 27. PMID 32759945 DOI: 10.1038/s41540-019-0104-5  0.179
1999 Baldi P, Brunak S, Frasconi P, Soda G, Pollastri G. Exploiting the past and the future in protein secondary structure prediction. Bioinformatics (Oxford, England). 15: 937-46. PMID 10743560  0.178
2002 Gupta R, Brunak S. Prediction of glycosylation across the human proteome and the correlation to protein function Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 310-322. PMID 11928486  0.176
1999 Gorodkin J, Lund O, Andersen CA, Brunak S. Using sequence motifs for enhanced neural network prediction of protein distance constraints. Proceedings / ... International Conference On Intelligent Systems For Molecular Biology ; Ismb. International Conference On Intelligent Systems For Molecular Biology. 95-105. PMID 10786291  0.172
2019 Ørntoft TF, Brunak S, Jespergaard C, Heickendorff L, Grønkjær K, Løngreen P. [Infrastructure of clinical support and research in the Danish national genome centre]. Ugeskrift For Laeger. 181. PMID 30950376  0.172
2023 Johansson Å, Andreassen OA, Brunak S, Franks PW, Hedman H, Loos RJF, Meder B, Melén E, Wheelock CE, Jacobsson B. Precision medicine in complex diseases-Molecular subgrouping for improved prediction and treatment stratification. Journal of Internal Medicine. PMID 37093654 DOI: 10.1111/joim.13640  0.17
2016 Nzabonimpa GS, Rasmussen HB, Brunak S, Taboureau O. Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches. Drug Metabolism and Personalized Therapy. PMID 26900165 DOI: 10.1515/dmpt-2015-0034  0.167
2007 Panitz F, Stengaard H, Hornshøj H, Gorodkin J, Hedegaard J, Cirera S, Thomsen B, Madsen LB, Høj A, Vingborg RK, Zahn B, Wang X, Wang X, Wernersson R, Jørgensen CB, ... ... Brunak S, et al. SNP mining porcine ESTs with MAVIANT, a novel tool for SNP evaluation and annotation. Bioinformatics (Oxford, England). 23: i387-91. PMID 17646321 DOI: 10.1093/bioinformatics/btm192  0.167
2022 Uellendahl-Werth F, Maj C, Borisov O, Juzenas S, Wacker EM, Jørgensen IF, Steiert TA, Bej S, Krawitz P, Hoffmann P, Schramm C, Wolkenhauer O, Banasik K, Brunak S, Schreiber S, et al. Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease. Communications Biology. 5: 80. PMID 35058554 DOI: 10.1038/s42003-022-03031-6  0.166
2021 Zheng T, Ellinghaus D, Juzenas S, Cossais F, Burmeister G, Mayr G, Jørgensen IF, Teder-Laving M, Skogholt AH, Chen S, Strege PR, Ito G, Banasik K, Becker T, Bokelmann F, ... Brunak S, et al. Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Gut. PMID 33888516 DOI: 10.1136/gutjnl-2020-323868  0.164
2022 Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Rühlemann MC, Arora J, Özer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, ... ... Brunak S, et al. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics. PMID 35848942 DOI: 10.1093/hmg/ddac158  0.161
2023 Bjornsdottir G, Chalmer MA, Stefansdottir L, Skuladottir AT, Einarsson G, Andresdottir M, Beyter D, Ferkingstad E, Gretarsdottir S, Halldorsson BV, Halldorsson GH, Helgadottir A, Helgason H, Hjorleifsson Eldjarn G, Jonasdottir A, ... ... Brunak S, et al. Rare variants with large effects provide functional insights into the pathology of migraine subtypes, with and without aura. Nature Genetics. PMID 37884687 DOI: 10.1038/s41588-023-01538-0  0.161
2023 Lundgaard AT, Burdet F, Siggaard T, Westergaard D, Vagiaki D, Cantwell L, Röder T, Vistisen D, Sparsø T, Giordano GN, Ibberson M, Banasik K, Brunak S. BALDR: A Web-based platform for informed comparison and prioritization of biomarker candidates for type 2 diabetes mellitus. Plos Computational Biology. 19: e1011403. PMID 37590326 DOI: 10.1371/journal.pcbi.1011403  0.156
2022 Teufel F, Almagro Armenteros JJ, Johansen AR, Gíslason MH, Pihl SI, Tsirigos KD, Winther O, Brunak S, von Heijne G, Nielsen H. SignalP 6.0 predicts all five types of signal peptides using protein language models. Nature Biotechnology. PMID 34980915 DOI: 10.1038/s41587-021-01156-3  0.155
2023 Moulder R, Välikangas T, Hirvonen MK, Suomi T, Brorsson CA, Lietzén N, Bruggraber SFA, Overbergh L, Dunger DB, Peakman M, Chmura PJ, Brunak S, Schulte AM, Mathieu C, Knip M, et al. Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory. Diabetologia. PMID 37537394 DOI: 10.1007/s00125-023-05974-9  0.152
2022 Collins R, Balaconis MK, Brunak S, Chen Z, De Silva M, Gaziano JM, Ginsburg GS, Jha P, Kuri P, Metspalu A, Mulder N, Risch N. Global priorities for large-scale biomarker-based prospective cohorts. Cell Genomics. 2: 100141. PMID 36778137 DOI: 10.1016/j.xgen.2022.100141  0.145
2023 Slieker RC, Donnelly LA, Akalestou E, Lopez-Noriega L, Melhem R, Güneş A, Abou Azar F, Efanov A, Georgiadou E, Muniangi-Muhitu H, Sheikh M, Giordano GN, Åkerlund M, Ahlqvist E, Ali A, ... ... Brunak S, et al. Identification of biomarkers for glycaemic deterioration in type 2 diabetes. Nature Communications. 14: 2533. PMID 37137910 DOI: 10.1038/s41467-023-38148-7  0.143
2023 Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, ... ... Brunak S, et al. Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target. Nature Genetics. PMID 37845353 DOI: 10.1038/s41588-023-01510-y  0.14
2023 Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, ... ... Brunak S, et al. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. PMID 36593394 DOI: 10.1038/s41587-022-01520-x  0.137
2022 Wesolowska-Andersen A, Brorsson CA, Bizzotto R, Mari A, Tura A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Prehn C, Artati A, Hong MG, Musholt PB, ... ... Brunak S, et al. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study. Cell Reports. Medicine. 3: 100477. PMID 35106505 DOI: 10.1016/j.xcrm.2021.100477  0.136
1999 Baldi P, Brunak S, Chauvin Y, Pedersen AG. Structural basis for triplet repeat disorders: A computational analysis Bioinformatics. 15: 918-929. PMID 10743558  0.135
2024 Sequeros CB, Hansen TF, Westergaard D, Louloudis I, Kalamajski S, Röder T, Rohde PD, Schwinn M, Clemmensen LH, Didriksen M, Nyegaard M, Hjalgrim H, Nielsen KR, Bruun MT, Ostrowski SR, ... ... Brunak S, et al. A genome-wide association study of social trust in 33,882 Danish blood donors. Scientific Reports. 14: 1402. PMID 38228779 DOI: 10.1038/s41598-024-51636-0  0.134
2022 Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M, Kahraman A, Pulido-Tamayo S, Barenboim J, Wadi L, Dhingra P, Shrestha R, Getz G, Lawrence MS, Pedersen JS, Rubin MA, ... ... Brunak S, et al. Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes. Nature Communications. 13: 7566. PMID 36481610 DOI: 10.1038/s41467-022-32334-9  0.133
2022 Hindy G, Tyrrell DJ, Vasbinder A, Wei C, Presswalla F, Wang H, Blakely PK, Ozel AB, Graham SE, Holton GH, Dowsett J, Fahed AC, Amadi KM, Erne GK, Tekumulla A, ... ... Brunak S, et al. Clinical, genetic, and experimental increase in soluble urokinase plasminogen activator receptor levels promotes atherosclerosis. The Journal of Clinical Investigation. PMID 36194491 DOI: 10.1172/JCI158788  0.132
2000 Baldi P, Pollastri G, Andersen CA, Brunak S. Matching protein beta-sheet partners by feedforward and recurrent neural networks. Proceedings / ... International Conference On Intelligent Systems For Molecular Biology ; Ismb. International Conference On Intelligent Systems For Molecular Biology. 8: 25-36. PMID 10977063  0.132
1998 Hansen JE, Lund O, Nilsson J, Rapacki K, Brunak S. O-GLYCBASE version 3.0: A revised database of O-glycosylated proteins Nucleic Acids Research. 26: 387-389. PMID 9399880 DOI: 10.1093/nar/26.1.387  0.131
1999 Baldi P, Borodovsky M, Brunak S, Burge C, Fickett J, Henikoff S, Koonin E, Sali A, Sander C, Stormo G. The Second International Conference on Bioinformatics: Sequence, Structure and Function, Atlanta, Georgia, November 11-14 1999: Editorial Bioinformatics. 15: 865-866.  0.128
2020 Siggaard T, Reguant R, Jørgensen IF, Haue AD, Lademann M, Aguayo-Orozco A, Hjaltelin JX, Jensen AB, Banasik K, Brunak S. Disease trajectory browser for exploring temporal, population-wide disease progression patterns in 7.2 million Danish patients. Nature Communications. 11: 4952. PMID 33009368 DOI: 10.1038/s41467-020-18682-4  0.126
2020 Gudmundsdottir V, Pedersen HK, Mazzoni G, Allin KH, Artati A, Beulens JW, Banasik K, Brorsson C, Cederberg H, Chabanova E, De Masi F, Elders PJ, Forgie I, Giordano GN, Grallert H, ... ... Brunak S, et al. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study. Genome Medicine. 12: 109. PMID 33261667 DOI: 10.1186/s13073-020-00806-6  0.126
2023 Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, et al. Gene expression signature predicts rate of type 1 diabetes progression. Ebiomedicine. 92: 104625. PMID 37224769 DOI: 10.1016/j.ebiom.2023.104625  0.125
2021 Aguayo-Orozco A, Haue AD, Jørgensen IF, Westergaard D, Moseley PL, Mortensen LH, Brunak S. Optimizing drug selection from a prescription trajectory of one patient. Npj Digital Medicine. 4: 150. PMID 34671068 DOI: 10.1038/s41746-021-00522-4  0.124
2024 Ghouse J, Sveinbjörnsson G, Vujkovic M, Seidelin AS, Gellert-Kristensen H, Ahlberg G, Tragante V, Rand SA, Brancale J, Vilarinho S, Lundegaard PR, Sørensen E, Erikstrup C, Bruun MT, Jensen BA, ... Brunak S, et al. Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis. Nature Genetics. PMID 38632349 DOI: 10.1038/s41588-024-01720-y  0.124
2023 Placido D, Thorsen-Meyer HC, Kaas-Hansen BS, Reguant R, Brunak S. Development of a dynamic prediction model for unplanned ICU admission and mortality in hospitalized patients. Plos Digital Health. 2: e0000116. PMID 37294826 DOI: 10.1371/journal.pdig.0000116  0.123
2022 Kaas-Hansen BS, Placido D, Rodríguez CL, Thorsen-Meyer HC, Gentile S, Nielsen AP, Brunak S, Jürgens G, Andersen SE. Language-agnostic pharmacovigilant text mining to elicit side effects from clinical notes and hospital medication records. Basic & Clinical Pharmacology & Toxicology. PMID 35834334 DOI: 10.1111/bcpt.13773  0.122
2022 Thorsen-Meyer HC, Placido D, Kaas-Hansen BS, Nielsen AP, Lange T, Nielsen AB, Toft P, Schierbeck J, Strøm T, Chmura PJ, Heimann M, Belling K, Perner A, Brunak S. Discrete-time survival analysis in the critically ill: a deep learning approach using heterogeneous data. Npj Digital Medicine. 5: 142. PMID 36104486 DOI: 10.1038/s41746-022-00679-6  0.122
2023 Placido D, Yuan B, Hjaltelin JX, Zheng C, Haue AD, Chmura PJ, Yuan C, Kim J, Umeton R, Antell G, Chowdhury A, Franz A, Brais L, Andrews E, Marks DS, ... ... Brunak S, et al. A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories. Nature Medicine. PMID 37156936 DOI: 10.1038/s41591-023-02332-5  0.121
2006 Neshich G, Bourne PE, Brunak S. ISMB 2006. Plos Computational Biology. 2: e11. PMID 16758006 DOI: 10.1371/journal.pcbi.0020011  0.12
2001 Brunak S, Krogh A. ISMB 2001 Bioinformatics. 17: S1-S4. DOI: 10.1093/bioinformatics/17.suppl_1.s1  0.12
2024 Foreman AL, Warth B, Hessel EVS, Price EJ, Schymanski EL, Cantelli G, Parkinson H, Hecht H, Klánová J, Vlaanderen J, Hilscherova K, Vrijheid M, Vineis P, Araujo R, Barouki R, ... ... Brunak S, et al. Adopting Mechanistic Molecular Biology Approaches in Exposome Research for Causal Understanding. Environmental Science & Technology. PMID 38641325 DOI: 10.1021/acs.est.3c07961  0.12
2024 Gjødsbøl IM, Ringgaard AK, Holm PC, Brunak S, Bundgaard H. The robot butler: How and why should we study predictive algorithms and artificial intelligence (AI) in healthcare? Digital Health. 10: 20552076241241674. PMID 38528969 DOI: 10.1177/20552076241241674  0.12
2024 Sequeros CB, Tulstrup M, Bliddal S, Sørensen KM, Nissen I, Rezahosseini O, Brooks PT, Feenstra B, Gang AO, Geller F, Hald A, Harboe ZB, Helleberg M, Jespersen JS, Lebech AM, ... ... Brunak S, et al. Clonal hematopoiesis and COVID-19 hospitalization in Danish adults. Hemasphere. 8: e58. PMID 38463443 DOI: 10.1002/hem3.58  0.12
2022 Leffers HCB, Westergaard D, Saevarsdottir S, Jonsdottir I, Pedersen OB, Genomic Consortium D, Troldborg A, Voss A, Kristensen S, Lindhardsen J, Kumar P, Linauskas A, Juul L, Krogh NS, Deleuran B, ... ... Brunak S, et al. Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: a Danish genome-wide association study. Joint Bone Spine. 105357. PMID 35167971 DOI: 10.1016/j.jbspin.2022.105357  0.12
2021 Reguant R, Brunak S, Saha S. Understanding inherent image features in CNN-based assessment of diabetic retinopathy. Scientific Reports. 11: 9704. PMID 33958686 DOI: 10.1038/s41598-021-89225-0  0.119
2022 Ghouse J, Tragante V, Muhammad A, Ahlberg G, Skov MW, Roden DM, Jonsdottir I, Andreasen L, Lundegaard PR, Trudsø LC, Banasik K, Brunak S, Ostrowski SR, Torp-Pedersen C, Pedersen OV, et al. Polygenic risk score for ACE-inhibitor-associated cough based on the discovery of new genetic loci. European Heart Journal. PMID 35751511 DOI: 10.1093/eurheartj/ehac322  0.117
2024 Steinthorsdottir V, Halldorsson BV, Jonsson H, Palsson G, Oddsson A, Westergaard D, Arnadottir GA, Stefansdottir L, Banasik K, Esplin MS, Hansen TF, Brunak S, Nyegaard M, Ostrowski SR, Pedersen OBV, et al. Variant in the synaptonemal complex protein SYCE2 associates with pregnancy loss through effect on recombination. Nature Structural & Molecular Biology. PMID 38287193 DOI: 10.1038/s41594-023-01209-y  0.117
2023 Pærregaard SI, Wulff L, Schussek S, Niss K, Mörbe U, Jendholm J, Wendland K, Andrusaite AT, Brulois KF, Nibbs RJB, Sitnik K, Mowat AM, Butcher EC, Brunak S, Agace WW. The small and large intestine contain related mesenchymal subsets that derive from embryonic Gli1 precursors. Nature Communications. 14: 2307. PMID 37085516 DOI: 10.1038/s41467-023-37952-5  0.116
2023 Muse VP, Aguayo-Orozco A, Balaganeshan SB, Brunak S. Population-wide analysis of hospital laboratory tests to assess seasonal variation and temporal reference interval modification. Patterns (New York, N.Y.). 4: 100778. PMID 37602220 DOI: 10.1016/j.patter.2023.100778  0.116
2023 Westergaard D, Steinthorsdottir V, Stefansdottir L, Rohde PD, Wu X, Geller F, Tyrmi J, Havulinna AS, Navais PS, Flatley C, Ostrowski SR, Pedersen OB, Erikstrup C, Sørensen E, Mikkelsen C, ... ... Brunak S, et al. Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage. Medrxiv : the Preprint Server For Health Sciences. PMID 37645979 DOI: 10.1101/2023.08.10.23293932  0.116
2022 Bjornsdottir G, Stefansdottir L, Thorleifsson G, Sulem P, Norland K, Ferkingstad E, Oddsson A, Zink F, Lund SH, Nawaz MS, Bragi Walters G, Skuladottir AT, Gudjonsson SA, Einarsson G, Halldorsson GH, ... ... Brunak S, et al. Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology. Nature Communications. 13: 634. PMID 35110524 DOI: 10.1038/s41467-022-28167-1  0.115
1998 Baldi P, Chauvin Y, Brunak S, Gorodkin J, Pedersen AG. Computational applications of DNA structural scales. Proceedings / ... International Conference On Intelligent Systems For Molecular Biology ; Ismb. International Conference On Intelligent Systems For Molecular Biology. 6: 35-42. PMID 9783207  0.114
2024 Muse VP, Brunak S. Protocol for EHR laboratory data preprocessing and seasonal adjustment using R and RStudio. Star Protocols. 5: 102912. PMID 38427569 DOI: 10.1016/j.xpro.2024.102912  0.112
2023 Thorolfsdottir RB, Jonsdottir AB, Sveinbjornsson G, Aegisdottir HM, Oddsson A, Stefansson OA, Halldorsson GH, Saevarsdottir S, Thorleifsson G, Stefansdottir L, Pedersen OB, Sørensen E, Ghouse J, Raja AA, Zheng C, ... ... Brunak S, et al. Variants at the Interleukin 1 Gene Locus and Pericarditis. Jama Cardiology. PMID 38150231 DOI: 10.1001/jamacardio.2023.4820  0.108
2022 Skuladottir AT, Bjornsdottir G, Ferkingstad E, Einarsson G, Stefansdottir L, Nawaz MS, Oddsson A, Olafsdottir TA, Saevarsdottir S, Walters GB, Magnusson SH, Bjornsdottir A, Sveinsson OA, Vikingsson A, Hansen TF, ... ... Brunak S, et al. A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome. Nature Communications. 13: 1598. PMID 35332129 DOI: 10.1038/s41467-022-29133-7  0.107
2023 Snaebjarnarson AS, Helgadottir A, Arnadottir GA, Ivarsdottir EV, Thorleifsson G, Ferkingstad E, Einarsson G, Sveinbjornsson G, Thorgeirsson TE, Ulfarsson MO, Halldorsson BV, Olafsson I, Erikstrup C, Pedersen OB, Nyegaard M, ... ... Brunak S, et al. Complex effects of sequence variants on lipid levels and coronary artery disease. Cell. 186: 4085-4099.e15. PMID 37714134 DOI: 10.1016/j.cell.2023.08.012  0.105
2020 Grissa D, Nytoft Rasmussen D, Krag A, Brunak S, Juhl Jensen L. Alcoholic liver disease: A registry view on comorbidities and disease prediction. Plos Computational Biology. 16: e1008244. PMID 32960884 DOI: 10.1371/journal.pcbi.1008244  0.105
2018 Haue AD, Vissing CR, Tfelt-Hansen J, Brunak S, Bundgaard H, Weeke PE. [Precision cardiology]. Ugeskrift For Laeger. 180. PMID 30274592  0.103
2019 Nielsen AB, Thorsen-Meyer HC, Belling K, Nielsen AP, Thomas CE, Chmura PJ, Lademann M, Moseley PL, Heimann M, Dybdahl L, Spangsege L, Hulsen P, Perner A, Brunak S. Survival prediction in intensive-care units based on aggregation of long-term disease history and acute physiology: a retrospective study of the Danish National Patient Registry and electronic patient records. The Lancet. Digital Health. 1: e78-e89. PMID 33323232 DOI: 10.1016/S2589-7500(19)30024-X  0.103
1997 Hansen JE, Lund O, Rapacki K, Brunak S. O-GLYCBASE version 2.0: A revised database of O-glycosylated proteins Nucleic Acids Research. 25: 278-282. PMID 9016554 DOI: 10.1093/nar/25.1.278  0.102
2023 Ghouse J, Tragante V, Ahlberg G, Rand SA, Jespersen JB, Leinøe EB, Vissing CR, Trudsø L, Jonsdottir I, Banasik K, Brunak S, Ostrowski SR, Pedersen OB, Sørensen E, Erikstrup C, et al. Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism. Nature Genetics. PMID 36658437 DOI: 10.1038/s41588-022-01286-7  0.102
2024 Han W, Bhasuran B, Muse VP, Brunak S, Lin L, Hanna K, Huang Y, Bian J, He Z. Assessing the Seasonality of Lab Tests Among Patients with Alzheimer's Disease and Related Dementias in OneFlorida Data Trust. Medrxiv : the Preprint Server For Health Sciences. PMID 38562749 DOI: 10.1101/2024.03.18.24304494  0.101
2020 Thorsen-Meyer HC, Nielsen AB, Nielsen AP, Kaas-Hansen BS, Toft P, Schierbeck J, Strøm T, Chmura PJ, Heimann M, Dybdahl L, Spangsege L, Hulsen P, Belling K, Brunak S, Perner A. Dynamic and explainable machine learning prediction of mortality in patients in the intensive care unit: a retrospective study of high-frequency data in electronic patient records. The Lancet. Digital Health. 2: e179-e191. PMID 33328078 DOI: 10.1016/S2589-7500(20)30018-2  0.101
2020 Thorsen-Meyer HC, Nielsen AB, Nielsen AP, Kaas-Hansen BS, Toft P, Schierbeck J, Strøm T, Chmura PJ, Heimann M, Dybdahl L, Spangsege L, Hulsen P, Belling K, Brunak S, Perner A. Dynamic and explainable machine learning prediction of mortality in patients in the intensive care unit: a retrospective study of high-frequency data in electronic patient records. The Lancet. Digital Health. 2: e179-e191. PMID 33328078 DOI: 10.1016/S2589-7500(20)30018-2  0.101
2021 Kenner B, Chari ST, Kelsen D, Klimstra DS, Pandol SJ, Rosenthal M, Rustgi AK, Taylor JA, Yala A, Abul-Husn N, Andersen DK, Bernstein D, Brunak S, Canto MI, Eldar YC, et al. Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review. Pancreas. 50: 251-279. PMID 33835956 DOI: 10.1097/MPA.0000000000001762  0.101
2023 Johansen AZ, Novitski SI, Hjaltelin JX, Theile S, Boisen MK, Brunak S, Madsen DH, Nielsen DL, Chen IM. Plasma YKL-40 is associated with prognosis in patients with metastatic pancreatic cancer receiving immune checkpoint inhibitors in combination with radiotherapy. Frontiers in Immunology. 14: 1228907. PMID 37744345 DOI: 10.3389/fimmu.2023.1228907  0.101
2024 Muse VP, Placido D, Haue AD, Brunak S. Seasonally adjusted laboratory reference intervals to improve the performance of machine learning models for classification of cardiovascular diseases. Bmc Medical Informatics and Decision Making. 24: 62. PMID 38438861 DOI: 10.1186/s12911-024-02467-6  0.1
2023 Leal Rodríguez C, Haue AD, Mazzoni G, Eriksson R, Hernansanz Biel J, Cantwell L, Westergaard D, Belling KG, Brunak S. Drug dosage modifications in 24 million in-patient prescriptions covering eight years: A Danish population-wide study of polypharmacy. Plos Digital Health. 2: e0000336. PMID 37676853 DOI: 10.1371/journal.pdig.0000336  0.1
1997 Knudsen S, Brunak S. Kissing loops hide premature termination codons in pre-mRNA of selenoprotein genes and in genes containing programmed ribosomal frameshifts Rna. 3: 697-701. PMID 9214653  0.098
2014 Roitmann E, Eriksson R, Brunak S. Patient stratification and identification of adverse event correlations in the space of 1190 drug related adverse events. Frontiers in Physiology. 5: 332. PMID 25249979 DOI: 10.3389/fphys.2014.00332  0.097
2021 Ghouse J, Ahlberg G, Andreasen L, Banasik K, Brunak S, Schwinn M, Larsen IH, Petersen O, Sørensen E, Ullum H, Rasmussen ER, Eriksson N, Hallberg P, Wadelius M, Bundgaard H, et al. Association of Variants Near the Bradykinin Receptor B Gene With Angioedema in Patients Taking ACE Inhibitors. Journal of the American College of Cardiology. 78: 696-709. PMID 34384552 DOI: 10.1016/j.jacc.2021.05.054  0.097
2023 Beaumont RN, Flatley C, Vaudel M, Wu X, Chen J, Moen GH, Skotte L, Helgeland Ø, Solé-Navais P, Banasik K, Albiñana C, Ronkainen J, Fadista J, Stinson SE, Trajanoska K, ... ... Brunak S, et al. Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. Nature Genetics. PMID 37798380 DOI: 10.1038/s41588-023-01520-w  0.095
2004 Lundegaard C, Nielsen M, Lamberth K, Worning P, Sylvester-Hvid C, Buus S, Brunak S, Lund O. MHC class I epitope binding prediction trained on small data sets Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 3239: 217-225.  0.095
2023 Hjaltelin JX, Currant H, Jørgensen IF, Brunak S. Visualising disease trajectories from population-wide data. Frontiers in Bioinformatics. 3: 1112113. PMID 36844930 DOI: 10.3389/fbinf.2023.1112113  0.094
2021 Laursen IH, Banasik K, Haue AD, Petersen O, Holm PC, Westergaard D, Bundgaard H, Brunak S, Frikke-Schmidt R, Holm H, Sørensen E, Thørner LW, Larsen MAH, Schwinn M, Køber L, et al. Cohort profile: Copenhagen Hospital Biobank - Cardiovascular Disease Cohort (CHB-CVDC): Construction of a large-scale genetic cohort to facilitate a better understanding of heart diseases. Bmj Open. 11: e049709. PMID 36070241 DOI: 10.1136/bmjopen-2021-049709  0.093
2022 Lindsø Andersen P, Jørgensen IF, Saunte DML, Jemec GB, Pedersen OB, Brunak S. An Increase in Specialist Treatment for Onychomycosis: An Unexplained Tendency. A Retrospective Study of Patients Treated for Onychomycosis in Danish Hospitals from 1994 to 2018. Journal of Fungi (Basel, Switzerland). 9. PMID 36675854 DOI: 10.3390/jof9010033  0.092
2023 Bruun-Rasmussen P, Hanefeld Dziegiel M, Banasik K, Johansson PI, Brunak S. Associations of ABO and Rhesus D blood groups with phenome-wide disease incidence: A 41-year retrospective cohort study of 482,914 patients. Elife. 12. PMID 36892462 DOI: 10.7554/eLife.83116  0.092
2023 Hjaltelin JX, Novitski SI, Jørgensen IF, Siggaard T, Vulpius SA, Westergaard D, Johansen JS, Chen IM, Juhl Jensen L, Brunak S. Pancreatic cancer symptom trajectories from Danish registry data and free text in electronic health records. Elife. 12. PMID 37988407 DOI: 10.7554/eLife.84919  0.091
2021 Jørgensen IF, Brunak S. Time-ordered comorbidity correlations identify patients at risk of mis- and overdiagnosis. Npj Digital Medicine. 4: 12. PMID 33514862 DOI: 10.1038/s41746-021-00382-y  0.091
2022 Saevarsdottir S, Stefansdottir L, Sulem P, Thorleifsson G, Ferkingstad E, Rutsdottir G, Glintborg B, Westerlind H, Grondal G, Loft IC, Sorensen SB, Lie BA, Brink M, Ärlestig L, Arnthorsson AO, ... ... Brunak S, et al. Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset. Annals of the Rheumatic Diseases. PMID 35470158 DOI: 10.1136/annrheumdis-2021-221754  0.091
2020 Börcsök J, Sztupinszki Z, Bekele R, Gao SP, Diossy M, Samant AS, Dillon KM, Tisza V, Spisák S, Rusz O, Csabai I, Pappot H, Frazier ZJ, Konieczkowski DJ, Liu D, ... ... Brunak S, et al. Identification of a synthetic lethal relationship between nucleotide excision repair (NER) deficiency and irofulven sensitivity in urothelial cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33208343 DOI: 10.1158/1078-0432.CCR-20-3316  0.089
2023 Vulpius SA, Werge S, Jørgensen IF, Siggaard T, Hernansanz Biel J, Knudsen GM, Brunak S, Pinborg LH. Text mining of electronic health records can validate a register-based diagnosis of epilepsy and subgroup into focal and generalized epilepsy. Epilepsia. PMID 37548470 DOI: 10.1111/epi.17734  0.086
2023 Aegisdottir HM, Thorolfsdottir RB, Sveinbjornsson G, Stefansson OA, Gunnarsson B, Tragante V, Thorleifsson G, Stefansdottir L, Thorgeirsson TE, Ferkingstad E, Sulem P, Norddahl G, Rutsdottir G, Banasik K, Christensen AH, ... ... Brunak S, et al. Genetic variants associated with syncope implicate neural and autonomic processes. European Heart Journal. PMID 36747475 DOI: 10.1093/eurheartj/ehad016  0.085
2024 Kjerulff B, Dowsett J, Jacobsen RL, Gladov J, Larsen MH, Lundgaard AT, Banasik K, Westergaard D, Mikkelsen S, Dinh KM, Hindhede L, Kaspersen KA, Schwinn M, Juul A, Poulsen B, ... ... Brunak S, et al. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors. Communications Medicine. 4: 50. PMID 38493237 DOI: 10.1038/s43856-024-00474-2  0.085
2021 Romero Herrera JA, Thomsen ST, Jakobsen L, Fagt S, Banasik K, Izarzugaza JM, Brunak S, Pires SM. The burden of disease of three food-associated heavy metals in clusters in the Danish population - towards targeted public health strategies. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112072. PMID 33610621 DOI: 10.1016/j.fct.2021.112072  0.085
2021 Staunstrup LM, Bager CL, Frederiksen P, Helge JW, Brunak S, Christiansen C, Karsdal M. Endotrophin is associated with chronic multimorbidity and all-cause mortality in a cohort of elderly women. Ebiomedicine. 68: 103391. PMID 34044221 DOI: 10.1016/j.ebiom.2021.103391  0.085
2022 Dahlgren MW, Plumb AW, Niss K, Lahl K, Brunak S, Johansson-Lindbom B. Type I Interferons Promote Germinal Centers Through B Cell Intrinsic Signaling and Dendritic Cell Dependent Th1 and Tfh Cell Lineages. Frontiers in Immunology. 13: 932388. PMID 35911733 DOI: 10.3389/fimmu.2022.932388  0.084
2019 Moseley PL, Brunak S. Identifying Sepsis Phenotypes. Jama. 322: 1416-1417. PMID 31593266 DOI: 10.1001/jama.2019.12591  0.084
2016 Beck MK, Westergaard D, Jensen AB, Groop L, Brunak S. TEMPORAL ORDER OF DISEASE PAIRS AFFECTS SUBSEQUENT DISEASE TRAJECTORIES: THE CASE OF DIABETES AND SLEEP APNEA. Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing. 22: 380-389. PMID 27896991  0.084
2022 Henkel C, Styrkársdóttir U, Thorleifsson G, Stefánsdóttir L, Björnsdóttir G, Banasik K, Brunak S, Erikstrup C, Dinh KM, Hansen TF, Nielsen KR, Bruun MT, Dowsett J, Brodersen T, Thorgeirsson TE, et al. Genome-wide association meta-analysis of knee and hip osteoarthritis uncovers genetic differences between patients treated with joint replacement and patients without joint replacement. Annals of the Rheumatic Diseases. PMID 36376028 DOI: 10.1136/ard-2022-223199  0.084
2021 Börcsök J, Diossy M, Sztupinszki Z, Prosz A, Tisza V, Spisak S, Rusz O, Stormoen DR, Pappot H, Csabai I, Brunak S, Mouw KW, Szallasi Z. Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33947694 DOI: 10.1158/1078-0432.CCR-20-5037  0.08
2010 Brunak S. Integrating life science related data and tools – from the molecular level to the phenotype New Biotechnology. 27: S13. DOI: 10.1016/j.nbt.2010.01.321  0.08
2021 Varga TV, Liu J, Goldberg RB, Chen G, Dagogo-Jack S, Lorenzo C, Mather KJ, Pi-Sunyer X, Brunak S, Temprosa M. Predictive utilities of lipid traits, lipoprotein subfractions and other risk factors for incident diabetes: a machine learning approach in the Diabetes Prevention Program. Bmj Open Diabetes Research & Care. 9. PMID 33789908 DOI: 10.1136/bmjdrc-2020-001953  0.08
2023 Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Leal Rodríguez C, Brasas V, Webel H, Benros ME, Pedersen AG, ... ... Brunak S, et al. Author Correction: Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models. Nature Biotechnology. PMID 37130959 DOI: 10.1038/s41587-023-01805-9  0.078
2020 Koivula RW, Atabaki-Pasdar N, Giordano GN, White T, Adamski J, Bell JD, Beulens J, Brage S, Brunak S, De Masi F, Dermitzakis ET, Forgie IM, Frost G, Hansen T, Hansen TH, et al. Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study. Diabetologia. PMID 33184701 DOI: 10.1007/s00125-020-05311-4  0.077
2020 Obura M, Beulens JWJ, Slieker R, Koopman ADM, Hoekstra T, Nijpels G, Elders P, Koivula RW, Kurbasic A, Laakso M, Hansen TH, Ridderstråle M, Hansen T, Pavo I, Forgie I, ... ... Brunak S, et al. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study. Plos One. 15: e0242360. PMID 33253307 DOI: 10.1371/journal.pone.0242360  0.076
2023 Pedersen MK, Eriksson R, Reguant R, Collin C, Pedersen HK, Sørup FKH, Simon C, Birch AM, Larsen M, Nielsen AP, Belling K, Brunak S. A unidirectional mapping of ICD-8 to ICD-10 codes, for harmonized longitudinal analysis of diseases. European Journal of Epidemiology. PMID 37555907 DOI: 10.1007/s10654-023-01027-y  0.076
2021 Thorolfsdottir RB, Sveinbjornsson G, Aegisdottir HM, Benonisdottir S, Stefansdottir L, Ivarsdottir EV, Halldorsson GH, Sigurdsson JK, Torp-Pedersen C, Weeke PE, Brunak S, Westergaard D, Pedersen OB, Sorensen E, Nielsen KR, et al. Genetic insight into sick sinus syndrome. European Heart Journal. 42: 1959-1971. PMID 36282123 DOI: 10.1093/eurheartj/ehaa1108  0.072
2021 Thorolfsdottir RB, Sveinbjornsson G, Aegisdottir HM, Benonisdottir S, Stefansdottir L, Ivarsdottir EV, Halldorsson GH, Sigurdsson JK, Torp-Pedersen C, Weeke PE, Brunak S, Westergaard D, Pedersen OB, Sorensen E, Nielsen KR, et al. Genetic insight into sick sinus syndrome. European Heart Journal. PMID 33580673 DOI: 10.1093/eurheartj/ehaa1108  0.072
2024 Jørgensen IF, Muse VP, Aguayo-Orozco A, Brunak S, Sørensen SS. Stratification of Kidney Transplant Recipients Into Five Subgroups Based on Temporal Disease Trajectories. Transplantation Direct. 10: e1576. PMID 38274475 DOI: 10.1097/TXD.0000000000001576  0.072
2022 Bruun-Rasmussen P, Andersen PK, Banasik K, Brunak S, Johansson PI. Intervening on the Storage Time of RBC Units and its Effects on Adverse Recipient Outcomes using Real-World Data. Blood. PMID 35482965 DOI: 10.1182/blood.2022015892  0.072
2020 Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, et al. ARDD 2020: from aging mechanisms to interventions. Aging. 12. PMID 33378272 DOI: 10.18632/aging.202454  0.069
2020 Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, et al. ARDD 2020: from aging mechanisms to interventions. Aging. 12. PMID 33378272 DOI: 10.18632/aging.202454  0.069
2022 Bruun-Rasmussen P, Andersen PK, Banasik K, Brunak S, Johansson PI. Estimating the effect of donor sex on red blood cell transfused patient mortality: A retrospective cohort study using a targeted learning and emulated trials-based approach. Eclinicalmedicine. 51: 101628. PMID 36176312 DOI: 10.1016/j.eclinm.2022.101628  0.068
2022 Rodríguez CL, Kaas-Hansen BS, Eriksson R, Biel JH, Belling KG, Andersen SE, Brunak S. Drug interactions in hospital prescriptions in Denmark: Prevalence and associations with adverse outcomes. Pharmacoepidemiology and Drug Safety. PMID 35124852 DOI: 10.1002/pds.5415  0.067
2023 Moslemi C, Saekmose SG, Larsen R, Bay JT, Brodersen T, Didriksen M, Hjalgrim H, Banasik K, Nielsen KR, Bruun MT, Dowsett J, Dinh KM, Mikkelsen S, Mikkelsen C, Hansen TF, ... ... Brunak S, et al. Genetic prediction of 33 blood group phenotypes using an existing genotype dataset. Transfusion. PMID 37921035 DOI: 10.1111/trf.17575  0.067
2022 Andreasen L, Ahlberg G, Ægisdóttir HM, Sveinbjörnsson G, Lundegaard PR, Hartmann JP, Paludan-Müller C, Hadji-Turdeghal K, Ghouse J, Pehrson S, Jensen HK, Riahi S, Hansen J, Sandgaard N, Sørensen E, ... ... Brunak S, et al. Genetic Variants Close to , and Associate With AVNRT. Circulation Research. 101161CIRCRESAHA1223. PMID 36205134 DOI: 10.1161/CIRCRESAHA.122.321556  0.065
2022 Mortensen LH, Brunak S. Reply to: Immortal time bias in the analysis of drug prescription trajectories. Npj Digital Medicine. 5: 191. PMID 36564452 DOI: 10.1038/s41746-022-00724-4  0.065
2022 Haue AD, Armenteros JJA, Holm PC, Eriksson R, Moseley PL, Køber LV, Bundgaard H, Brunak S. Temporal patterns of multi-morbidity in 570157 ischemic heart disease patients: a nationwide cohort study. Cardiovascular Diabetology. 21: 87. PMID 35641964 DOI: 10.1186/s12933-022-01527-3  0.064
2023 Yeung AWK, Torkamani A, Butte AJ, Glicksberg BS, Schuller B, Rodriguez B, Ting DSW, Bates D, Schaden E, Peng H, Willschke H, van der Laak J, Car J, Rahimi K, Celi LA, ... ... Brunak S, et al. The promise of digital healthcare technologies. Frontiers in Public Health. 11: 1196596. PMID 37822534 DOI: 10.3389/fpubh.2023.1196596  0.063
2022 Bjornsdottir G, Stefansdottir L, Thorleifsson G, Sulem P, Norland K, Ferkingstad E, Oddsson A, Zink F, Lund SH, Nawaz MS, Bragi Walters G, Skuladottir AT, Gudjonsson SA, Einarsson G, Halldorsson GH, ... ... Brunak S, et al. Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology. Nature Communications. 13: 2419. PMID 35477715 DOI: 10.1038/s41467-022-30129-6  0.062
2020 Sørensen E, Christiansen L, Wilkowski B, Larsen MH, Burgdorf KS, Thørner LW, Nissen J, Pedersen OB, Banasik K, Brunak S, Bundgaard H, Stefánsson H, Stefánsson K, Melbye M, Ullum H. Data Resource Profile: The Copenhagen Hospital Biobank (CHB). International Journal of Epidemiology. PMID 33169150 DOI: 10.1093/ije/dyaa157  0.06
2023 Styrkarsdottir U, Tragante V, Stefansdottir L, Thorleifsson G, Oddsson A, Sørensen E, Erikstrup C, Schwarz P, Jørgensen HL, Lauritzen JB, Brunak S, Knowlton KU, Nadauld LD, Ullum H, Pedersen OBV, et al. Obesity variants in the GIPR gene do not associate with risk of fracture or bone mineral density. The Journal of Clinical Endocrinology and Metabolism. PMID 38118020 DOI: 10.1210/clinem/dgad734  0.059
2021 Jørgensen IF, Brunak S. Time-ordered comorbidity correlations identify patients at risk of mis- and overdiagnosis. Npj Digital Medicine. 4: 12. PMID 33514862 DOI: 10.1038/s41746-021-00382-y  0.059
2021 Tura A, Grespan E, Göbl CS, Koivula RW, Franks PW, Pearson ER, Walker M, Forgie IM, Giordano GN, Pavo I, Ruetten H, Dermitzakis ET, McCarthy MI, Pedersen O, Schwenk JM, ... ... Brunak S, et al. Profiles of glucose metabolism in different prediabetes phenotypes, classified by fasting glycemia, 2-hour OGTT, glycated hemoglobin, and 1-hour OGTT: An IMI DIRECT study. Diabetes. PMID 34233929 DOI: 10.2337/db21-0227  0.058
2023 Oddsson A, Sulem P, Sveinbjornsson G, Arnadottir GA, Steinthorsdottir V, Halldorsson GH, Atlason BA, Oskarsson GR, Helgason H, Nielsen HS, Westergaard D, Karjalainen JM, Katrinardottir H, Fridriksdottir R, Jensson BO, ... ... Brunak S, et al. Publisher Correction: Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality. Nature Communications. 14: 3923. PMID 37400429 DOI: 10.1038/s41467-023-39492-4  0.056
2023 Chalmer MA, Kogelman LJA, Ullum H, Sørensen E, Didriksen M, Mikkelsen S, Dinh KM, Brodersen T, Nielsen KR, Bruun MT, Banasik K, Brunak S, Erikstrup C, Pedersen OB, Ostrowski SR, et al. Population-Based Characterization of Menstrual Migraine and Proposed Diagnostic Criteria. Jama Network Open. 6: e2313235. PMID 37184838 DOI: 10.1001/jamanetworkopen.2023.13235  0.056
2020 Bizzotto R, Jennison C, Jones AG, Kurbasic A, Tura A, Kennedy G, Bell JD, Thomas EL, Frost G, Eriksen R, Koivula RW, Brage S, Kaye J, Hattersley AT, Heggie A, ... ... Brunak S, et al. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study. Diabetes Care. PMID 33323478 DOI: 10.2337/dc20-1567  0.055
2017 Sørup F, Hallas J, Brunak S, Andersen S. Adverse Drug Events With Antipsychotics—A Sex Difference Clinical Therapeutics. 39: e56. DOI: 10.1016/J.CLINTHERA.2017.05.173  0.054
2021 Bell S, Rigas AS, Magnusson MK, Ferkingstad E, Allara E, Bjornsdottir G, Ramond A, Sørensen E, Halldorsson GH, Paul DS, Burgdorf KS, Eggertsson HP, Howson JMM, Thørner LW, Kristmundsdottir S, ... ... Brunak S, et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Communications Biology. 4: 156. PMID 33536631 DOI: 10.1038/s42003-020-01575-z  0.053
2022 Al-Jaberi FAH, Crone CG, Lindenstrøm T, Arildsen NS, Lindeløv ES, Aagaard L, Gravesen E, Mortensen R, Andersen AB, Olgaard K, Hjaltelin JX, Brunak S, Bonefeld CM, Kongsbak-Wismann M, Geisler C. Reduced vitamin D-induced cathelicidin production and killing of in macrophages from a patient with a non-functional vitamin D receptor: A case report. Frontiers in Immunology. 13: 1038960. PMID 36405761 DOI: 10.3389/fimmu.2022.1038960  0.053
2023 Nethander M, Movérare-Skrtic S, Kämpe A, Coward E, Reimann E, Grahnemo L, Borbély É, Helyes Z, Funck-Brentano T, Cohen-Solal M, Tuukkanen J, Koskela A, Wu J, Li L, Lu T, ... ... Brunak S, et al. An atlas of genetic determinants of forearm fracture. Nature Genetics. 55: 1820-1830. PMID 37919453 DOI: 10.1038/s41588-023-01527-3  0.052
2023 Vesterlund GK, Thorsen-Meyer HC, Møller MH, Brunak S, Strøm T, Perner A, Kaas-Hansen BS. Abnormal serum levels of magnesium, phosphate, and zinc in ICU patients-Characteristics, management, and outcomes: The WhyTrace cohort study. Acta Anaesthesiologica Scandinavica. PMID 37078441 DOI: 10.1111/aas.14247  0.05
2021 Al-Jaberi FAH, Kongsbak-Wismann M, Aguayo-Orozco A, Krogh N, Buus TB, Lopez DV, Rode AKO, Gravesen E, Olgaard K, Brunak S, Woetmann A, Ødum N, Bonefeld CM, Geisler C. Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets. Frontiers in Immunology. 12: 684015. PMID 34093587 DOI: 10.3389/fimmu.2021.684015  0.049
2022 Pérez-Alós L, Armenteros JJA, Madsen JR, Hansen CB, Jarlhelt I, Hamm SR, Heftdal LD, Pries-Heje MM, Møller DL, Fogh K, Hasselbalch RB, Rosbjerg A, Brunak S, Sørensen E, Larsen MAH, et al. Modeling of waning immunity after SARS-CoV-2 vaccination and influencing factors. Nature Communications. 13: 1614. PMID 35347129 DOI: 10.1038/s41467-022-29225-4  0.049
2015 Weegar R, Kvist M, Sundström K, Brunak S, Dalianis H. Finding Cervical Cancer Symptoms in Swedish Clinical Text using a Machine Learning Approach and NegEx. Amia ... Annual Symposium Proceedings / Amia Symposium. Amia Symposium. 2015: 1296-305. PMID 26958270  0.048
2021 Bliddal S, Banasik K, Pedersen OB, Nissen J, Cantwell L, Schwinn M, Tulstrup M, Westergaard D, Ullum H, Brunak S, Tommerup N, Feenstra B, Geller F, Ostrowski SR, Grønbæk K, et al. Acute and persistent symptoms in non-hospitalized PCR-confirmed COVID-19 patients. Scientific Reports. 11: 13153. PMID 34162913 DOI: 10.1038/s41598-021-92045-x  0.048
2022 Kaas-Hansen BS, Leal Rodríguez C, Placido D, Thorsen-Meyer HC, Nielsen AP, Dérian N, Brunak S, Andersen SE. Using Machine Learning to Identify Patients at High Risk of Inappropriate Drug Dosing in Periods with Renal Dysfunction. Clinical Epidemiology. 14: 213-223. PMID 35228820 DOI: 10.2147/CLEP.S344435  0.047
2023 Sanz F, Pognan F, Steger-Hartmann T, Díaz C, Asakura S, Amberg A, Bécourt-Lhote N, Blomberg N, Bosc N, Briggs K, Bringezu F, Brulle-Wohlhueter C, Brunak S, Bueters R, Callegaro G, et al. eTRANSAFE: data science to empower translational safety assessment. Nature Reviews. Drug Discovery. PMID 37316648 DOI: 10.1038/d41573-023-00099-5  0.047
2020 Herrera JAR, Bang AK, Priskorn L, Izarzugaza JMG, Brunak S, Jørgensen N. Semen quality and waiting time to pregnancy explored using Association Mining. Andrology. PMID 33084252 DOI: 10.1111/andr.12924  0.047
2021 Kolte AM, Westergaard D, Lidegaard Ø, Brunak S, Nielsen HS. The impact of early pregnancy complications on completed family size-A nationwide, registry-based cohort study with 40 years of data. Acta Obstetricia Et Gynecologica Scandinavica. PMID 34546567 DOI: 10.1111/aogs.14265  0.046
2022 Chen IM, Johansen JS, Theile S, Hjaltelin JX, Novitski SI, Brunak S, Hasselby JP, Willemoe GL, Lorentzen T, Madsen K, Jensen BV, Wilken EE, Geertsen P, Behrens C, Nolsoe C, et al. Randomized Phase II Study of Nivolumab With or Without Ipilimumab Combined With Stereotactic Body Radiotherapy for Refractory Metastatic Pancreatic Cancer (CheckPAC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2102511. PMID 35476508 DOI: 10.1200/JCO.21.02511  0.046
2001 Frimurer TM, Bywater R, Naerum L, Lauritsen LN, Brunak S. ChemInform Abstract: Improving the Odds in Discriminating “Drug-Like” from “Non Drug-Like” Compounds. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200105246  0.045
2021 Kolte AM, Westergaard D, Lidegaard Ø, Brunak S, Nielsen HS. Chance of live birth: a nationwide, registry-based cohort study. Human Reproduction (Oxford, England). PMID 33394013 DOI: 10.1093/humrep/deaa326  0.042
2021 Kolte AM, Westergaard D, Lidegaard Ø, Brunak S, Nielsen HS. Chance of live birth: a nationwide, registry-based cohort study. Human Reproduction (Oxford, England). PMID 33394013 DOI: 10.1093/humrep/deaa326  0.042
2022 Kaas-Hansen BS, Leal Rodríguez C, Placido D, Thorsen-Meyer HC, Nielsen AP, Dérian N, Brunak S, Andersen SE. Machine Learning to Identify Patients at Risk of Inappropriate Dosing for Renal Risk Medications: A Critical Comment on Kaas-Hansen et al [Response to Letter]. Clinical Epidemiology. 14: 765-766. PMID 35707498 DOI: 10.2147/CLEP.S375668  0.038
2022 Erikstrup C, Sørensen E, Nielsen KR, Bruun MT, Petersen MS, Rostgaard K, Thørner LW, Larsen M, Mikkelsen S, Dinh KM, Schwinn M, Rigas AS, Didriksen M, Dowsett J, von Stemann JH, ... ... Brunak S, et al. Cohort Profile: The Danish Blood Donor Study. International Journal of Epidemiology. PMID 36194120 DOI: 10.1093/ije/dyac194  0.038
2002 Skovgaard M, Jensen LJ, Friis C, Stærfeldt HH, Worning P, Brunak S, Ussery D. The Atlas visualization of genomewide information Methods in Microbiology. 33: 49-63.  0.036
2022 Helgadottir A, Thorleifsson G, Snaebjarnarson A, Stefansdottir L, Sveinbjornsson G, Tragante V, Björnsson E, Steinthorsdottir V, Gretarsdottir S, Helgason H, Saemundsdottir J, Olafsson I, Thune JJ, Axelsson Raja A, Ghouse J, ... ... Brunak S, et al. Cholesterol not particle concentration mediates the atherogenic risk conferred by apolipoprotein B particles - A Mendelian randomization analysis. European Journal of Preventive Cardiology. PMID 36125206 DOI: 10.1093/eurjpc/zwac219  0.029
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